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1.
Rev. Odontol. Araçatuba (Impr.) ; 42(3): 25-31, set.-dez. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1284114

ABSTRACT

Os pilares personalizados são usados em reabilitações protéticas sobre implantes quando há exigências de angulação, perfil de emergência e margem gengival, em que os pilares convencionais não conseguem reabilitar de forma correta os conceitos de forma, função e estética. Através de um relato de caso clínico, onde houve a reabilitação dos elementos 21 e 22, com o uso de implante e próteses, usando o pilar personalizado em zircônia sobre o implante do 22, confeccionado com a tecnologia CAD/CAM. Esse sistema de pilares personalizados oferecem o desenho mais próximo do ideal e o ajuste mais perfeito em relação ao implante e ao tecido gengival, além de considerar as vantagens e desvantagen em relação aos pilares convencionais pré-fabricados nas questões de tempo de tratamento, custos e resultado estético e biológico. Concluimos que a reabilitação com pilares personalizados CAD/CAM confere uma excelente alternativa reabilitadora, devolvendo função e estética aos pacientes, desde que haja conhecimento adequado por parte dos profissionais envolvidos(AU)


Custom abutments are used in prosthetic rehabilitation on implants when angulation, emergence profile and gingival margin are used, where abutments are not recovered in a correct way to rehabilitate the concepts of shape, functions and aesthetics. Through a clinical case, where the elements 21 and 22 were rehabilitated, with the use of implants and practices, using the personalized abutments in zirconia, made with CAD / CAM technology. This customized system and abutments offers the closest ideal design and the most perfect fit in relation to the implant and gingival tissue, in addition to considering advantages and disadvantages in relation to the prefabricated applied abutments in terms of treatment time, costs and results aesthetic and biological. Conclude that a rehabilitation with customized CAD / CAM abutments provides an excellent rehabilitation alternative, returning function and aesthetics to patients, as long as there is adequate knowledge for part of the professionals involved(AU)


Subject(s)
Humans , Female , Aged , Dental Implants , Computer-Aided Design , Biocompatible Materials , Dental Prosthesis, Implant-Supported , Esthetics, Dental
2.
Rev. ADM ; 78(5): 291-296, sept.-oct. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1348330

ABSTRACT

La anquilosis de la articulación temporomandibular en niños continúa siendo una patología presente a pesar de los avances médicos y sociales. El tratamiento de esta patología en niños tiene como objetivos restablecer la apertura bucal y mejorar la estética facial cuando se presentan hipoplasias o micrognatias asociadas. El uso de materiales aloplásticos para el tratamiento de la anquilosis temporomandibular en niños es evitar la reanquilosis y disminuir riesgos, molestias y costos que ocasionan la toma y aplicación de injertos, siendo utilizados con buenos resultados en niños en otras especialidades como la Traumatología y Ortopedia. Estos procedimientos pueden llevarse a cabo de manera segura y predecible. En este artículo se reportan dos casos de anquilosis temporomandibular en niños, tratados con materiales aloplásticos, llevados a cabo en la Unidad Médica de Alta Especialidad No. 71 del Instituto Mexicano del Seguro Social, Torreón, Coahuila, México, con un seguimiento de 11 y 16 años de postoperatorio, demostrando que se trata de una buena opción de tratamiento sin presentar alteraciones al crecimiento y desarrollo de los pacientes (AU)


Temporomandibular ankilosis in children is pathology still present despite the medical and social advances. The treatment of this pathology in children aims to restore mouth opening and improve facial aesthetics when hypoplasia or micrognatia are present. The use of alloplastic materials to treat temporomandibular ankilosis in children is to prevent the re ankilosis and reduce discomfort, risks, and cost causing by the take and application of graft, alloplastic materials being used with good results in children in other specialties such as Traumatology and Orthopedics. These procedures can be made safely and predictably. This article describes two cases of temporomandibular ankilosis in children, treated with alloplastic materials, carried out in the Medical Unit of High Specialty, number 71, of the Mexican Institute Social Security, Torreon, Coahuila, Mexico, with follow up of cases 11 and 16 years of postoperative, prove that is a good option of treatment, without presenting any alterations in growth and development of patients (AU)


Subject(s)
Humans , Male , Child , Biocompatible Materials , Temporomandibular Joint Disorders/therapy , Ankylosis/therapy , Maxillofacial Prosthesis , Titanium , Follow-Up Studies , Chromium Alloys , Genioplasty , Mandibular Condyle/injuries
3.
Rev. ADM ; 78(4): 195-204, jul.-ago. 2021. ilus, tab
Article in Spanish | LILACS | ID: biblio-1292500

ABSTRACT

Desde los sesentas, con la invención del vidrio bioactivo, los tratamientos de remineralización se han popularizado entre los cirujanos dentistas y su utilización es cada vez mayor; la remineralización, en conjunto con las adecuadas medidas de higiene preventiva, representa uno de los mejores abordajes mínimamente invasivos y a un costo comparativamente bajo. Este estudio documental tiene por objetivo establecer una mejor comprensión del uso clínico de los biomateriales que inducen la remineralización de la superficie del esmalte dental y dentina. Se realizó una exploración utilizando motores de búsqueda (bases de datos en PubMed, Medigraphic, y Science Direct). El proceso de localización de los estudios relevantes se efectuó introduciendo palabras clave como: silicatos de calcio, fosfopéptidos de caseína-fosfato de calcio amorfo, remineralización, esmalte y dentina, incluyéndose en el procedimiento artículos de antigüedad no superior a siete años, en español e inglés, publicados en revistas científicas aprobadas por pares.Actualmente, no es posible remineralizar del todo la estructura dentaria, por lo cual, en un futuro cercano, los esfuerzos de la odontología de remineralización deben apuntar al desarrollo de agentes biomiméticos inteligentes que restauren al cien por ciento la estructura dental perdida (AU)


Since the sixties, with the invention of bioactive glass, remineralization treatments have become popular among dental surgeons. Their usage is increasing; remineralization, in conjunction with appropriate preventive hygiene measures, represents one of the best minimally invasive treatments at a relatively low cost. This documentary study aims to establish a better understanding of the clinical use of biomaterials that induce remineralization of the surface of teeth enamel and dentin. A search was conducted using search engines (PubMed and Medigraphic databases, and Science Direct). The search process for the relevant studies was carried out by introducing keywords such as calcium silicates, phosphopeptides of amorphous calcium casein-phosphate, remineralization, enamel and dentin, including in the search articles no older than seven years in Spanish and English published in scientific reviewed journals. Currently, it is not possible to completely remineralize the dentary structure so, in the near future, remineralization dentistry efforts should aim to develop (AU)


Subject(s)
Humans , Tooth Remineralization/instrumentation , Biocompatible Materials , Dental Enamel/drug effects , Dentin/drug effects , Phosphopeptides/therapeutic use , Caseins , Calcarea Silicata/therapeutic use
4.
Rev. Odontol. Araçatuba (Impr.) ; 42(2): 52-55, maio-ago. 2021. ilus
Article in Portuguese | LILACS, BBO | ID: biblio-1283891

ABSTRACT

Pacientes com históricos de defeitos ósseos provocados por infecções, malformação congênita, neoplasias, deformação por iatrogenia, radioterapia e trauma buscam contornos faciais mais harmônicos através da reabilitação cirúrgica. Para facilitar a reconstrução maxilofacial dois grupos de materiais podem ser utilizados, os enxertos ósseos e os materiais aloplásticos. O objetivo é relatar um caso incomum de infecção e exposição de material utilizado para enxertia a base de polimetilmetacrilato, bem como a sua posterior reabordagem cirúrgica. Embora o Polimetilmetacrilato aparente ser seguro, ele exibe complicações diversas em função da imunologia do hospedeiro, que poderá reagir de diferentes formas. Desse modo, faz-se necessário ressaltar a importância da prevenção e proservação de cada caso de forma individualizada(AU)


Patients with a history of bone defects caused by infections, congenital malformation, neoplasms, iatrogenic deformation, radiotherapy and trauma seek more harmonious facial contours through surgical rehabilitation. To facilitate maxillofacial reconstruction, two groups of materials can be used, bone grafts and alloplastic materials. The objective is to report an unusual case of infection and exposure of material used for grafting with polymethylmethacrylate, as well as its subsequent surgical approach. Although Polymethylmethacrylate appears to be safe, it exhibits different complications depending on the host's immunology, which may react in different ways. Thus, it is necessary to emphasize the importance of preventing and preserving each case individually(AU)


Subject(s)
Humans , Female , Middle Aged , Bone Transplantation , Polymethyl Methacrylate , Maxillofacial Injuries , Orbit , Surgery, Oral , Zygoma , Biocompatible Materials , Iatrogenic Disease , Maxilla
5.
Rev. cuba. invest. bioméd ; 40(2): e570, 2021. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347461

ABSTRACT

Introducción: El panorama demográfico en el mundo está cambiando. La población mayor de 60 años es el segmento que está creciendo más rápidamente y en el que las enfermedades del tejido óseo se presentan con más frecuencia, lo que aumenta la demanda de materiales y tecnologías apropiadas para restaurar estos tejidos. Objetivo: Analizar la información que se ha generado sobre el desarrollo de biomateriales compuestos para la reparación ósea, con énfasis en la identificación de las tecnologías emergentes basadas en el uso del campo electromagnético, sus aplicaciones y potencialidades. Métodos: Se consultaron trabajos científicos publicados en libros, revistas, patentes y tesis. El 80 por ciento de la documentación seleccionada pertenece al periodo 2010-2019. Análisis e integración de la información: Los métodos identificados fueron clasificados en cinco grupos: electrodeposición química, ya sea por electrólisis, electroforesis o síntesis electroforética in situ; electroporación; electrohilado; control magnético distal y bioestimulación electromagnética de células y tejidos, directamente o por la introducción de dispositivos que convierten la energía electromagnética en energía mecánica. Conclusiones: Estos métodos permiten la conformación de matrices celulares y acelulares compuestas y, además, dispositivos bioestimuladores con control de los parámetros de construcción y acción, de tal manera, que se logran procesos con mayor grado de reproducibilidad y a la medida de los requerimientos específicos para cada paciente(AU)


Introduction: The global demographic panorama is changing. The population aged over 60 years is the fastest growing segment, as well as the one where bone tissue diseases are most common, increasing the demand of appropriate materials and technologies to restore those tissues. Objective: To analyze the information so far generated about the development of composite biomaterials for bone repair, with an emphasis on the identification of emerging technologies based on the use of the electromagnetic field, its applications and potential. Methods: An analysis was performed of scientific papers published in books, journals, patents and theses. Of the documentation selected, 80 percent was from the period 2010-2019. Data analysis and integration: The methods identified were classified into five groups: chemical electrodeposition, be it by in situ electrophoretic synthesis, electrolysis or electrophoresis; electroporation; electrospinning; distal magnetic control and electromagnetic biostimulation of cells and tissues, either directly or incorporating devices which convert electromagnetic energy into mechanical energy. Conclusions: These methods permit the conformation of composite cellular and acellular matrices as well as biostimulator devices controlling construction and action parameters in such a way that the processes obtained display greater reproducibility and are more in keeping with the specific requirements of each patient(AU)


Subject(s)
Humans , Biocompatible Materials/analysis , Electric Stimulation/methods , Electromagnetic Fields
6.
Arq. Ciênc. Vet. Zool. UNIPAR (Online) ; 24(1, cont.): e2403, jan-jun. 2021. tab, graf
Article in Portuguese | ID: biblio-1252764

ABSTRACT

O Whatman FTA-Card® é um papel-filtro quimicamente tratado, destinado à coleta, transporte, armazenamento de amostras para posterior extração de ácidos nucléicos. A tecnologia FTA-Card® é utilizada para manter estável DNA e RNA em temperatura ambiente, podendo ser utilizados para fixação de uma ampla variedade de material orgânico ou tecidos. Foram realizados testes para certificar sua eficiência na conservação do material a ser analisado com o intuito de eliminar a cadeia fria de conservação, agilizando o processo e diminuindo os custos da execução de exames moleculares associados ao diagnóstico de patologias. Foram testadas oito amostras de felinos na forma de sangue total e soro, para a extração utilizou-se o kit Magazorb RNA Total mini-prep kit (Promega®, EUA), para o diagnóstico foi utilizada a técnica de PCR em tempo real para amplificar o gene CI2 de mamíferos, a fim de visualizar a eficácia na conservação de ácidos nucleicos. A utilização desse método torna possível que o material biológico seja enviado por serviços de transporte postais, reduzindo os custos e viabilizando diagnósticos provenientes de áreas mais remotas.(AU)


Whatman FTA-Card® is a chemically treated filter paper intended for the collection, transport, and storage of samples for later extraction of nucleic acids. FTA-Card® technology is used to keep DNA and RNA stable at room temperature and can be used to fix a wide variety of organic material or tissues. Tests were carried out to certify its efficiency in the conservation of the material to be analyzed in order to eliminate the cold conservation chain, speeding up the process and decreasing the costs of performing molecular tests associated with the diagnosis of pathologies. By using this method, biological material can be sent by postal transport services, reducing costs and making diagnoses from more remote areas feasible. Samples of feline specimens were tested in the form of whole blood and serum, using the Magazorb RNA Total mini-prep kit (Promega®, USA) for the extraction. Diagnosis was performed using real-time PCR technique to amplify the mammalian CI2 gene in order to visualize the effectiveness in conserving nucleic acids.(AU)


Whatman FTA-Card® es un papel de filtro tratado químicamente, destinado a la recogida, transporte, almacenamiento de muestras para su posterior extracción de ácidos nucleicos. La tecnología FTA-Card® se usa para mantener el ADN y el ARN estables a la temperatura ambiente y se puede usar para la fijación de una amplia variedad de materiales o tejidos orgánicos. Se realizaron pruebas para certificar su eficiencia en la conservación del material a analizar con el fin de eliminar la cadena de frío de conservación, agilizando el proceso y reduciendo los costos de realización de pruebas moleculares asociadas al diagnóstico de patologías. Se analizaron ocho muestras felinas en forma de sangre total y suero, para la extracción se utilizó el mini-prep kit Magazorb RNA Total (Promega®, USA), para el diagnóstico se utilizó la técnica de PCR en tiempo real para amplificar el CI2 de mamífero gen, con el fin de visualizar la efectividad en la conservación de ácidos nucleicos. El uso de ese método permite el envío de material biológico por los servicios de transporte postal, lo que reduce los costes y permite realizar diagnósticos desde zonas más remotas.(AU)


Subject(s)
Biocompatible Materials , DNA , Materials , Real-Time Polymerase Chain Reaction
7.
Medisan ; 25(2)mar.-abr. 2021.
Article in Spanish | LILACS, CUMED | ID: biblio-1250353

ABSTRACT

La endodoncia regenerativa comprende un conjunto de procedimientos biológicos que se efectúan en los dientes permanentes con ápice no formado y necrosis pulpar, cuyo fin es sustituir los tejidos dañados, incluidas la dentina y la estructura radicular, así como las células del complejo pulpodentinario. En este artículo se describen las bases celulares y moleculares de esta terapia, sustentada en una compleja interacción entre las células madre dentales de la papila apical, los factores de crecimiento y los biomateriales con el microambiente donde se va a restablecer. Asimismo, se argumenta cómo las condiciones ambientales en las que se lleva a cabo el proceso terapéutico influyen en la regeneración, con una función esencial en la regulación de la diferenciación de los tejidos.


The regenerative endodontics comprises a group of biological procedures that are made in the permanent teeth with non-formed apex and pulpar necrosis whose end is to substitute the damaged tissues, including the dentine and radicular structure, as well as the cells of the dentin pulp complex. The cellular and molecular basis of this therapy are described in this work, sustained in a complex interaction between the dental stem cells of the apical papilla, the growth factors and biomaterials with the microenvironment where it will be recover. Likewise, it was argued how the environmental conditions in which the therapeutic process is carried out influence in the regeneration, with an essential function in the regulation of the differentiation of tissues.


Subject(s)
Stem Cells , Dentition, Permanent , Regenerative Endodontics/methods , Biocompatible Materials
8.
Braz. j. med. biol. res ; 54(9): e11055, 2021. tab, graf
Article in English | LILACS | ID: biblio-1278585

ABSTRACT

Because bone-associated diseases are increasing, a variety of tissue engineering approaches with bone regeneration purposes have been proposed over the last years. Bone tissue provides a number of important physiological and structural functions in the human body, being essential for hematopoietic maintenance and for providing support and protection of vital organs. Therefore, efforts to develop the ideal scaffold which is able to guide the bone regeneration processes is a relevant target for tissue engineering researchers. Several techniques have been used for scaffolding approaches, such as diverse types of biomaterials. On the other hand, metallic biomaterials are widely used as support devices in dentistry and orthopedics, constituting an important complement for the scaffolds. Hence, the aim of this review is to provide an overview of the degradable biomaterials and metal biomaterials proposed for bone regeneration in the orthopedic and dentistry fields in the last years.


Subject(s)
Humans , Orthopedics , Biocompatible Materials , Bone Regeneration , Tissue Engineering , Dentistry , Tissue Scaffolds
9.
Rev. Ateneo Argent. Odontol ; 64(1): 13-17, 2021. ilus
Article in Spanish | LILACS | ID: biblio-1248251

ABSTRACT

Se presenta un caso clínico de fractura radicular del tercio medio, de pieza 2.1 con desplazamiento de los cabos de fractura. Es tratado con un novedoso procedimiento terapéutico, mediante la utilización de un biomaterial de tercera generación osteoconductor, osteogénico y osteoinductor. Se obtiene la reparación del tejido conectivo interproximal y la formación de tejido calcificado (AU)


We present a clinical case of root fracture of the middle third, piece 2.1 with displacement of the fracture ends. It is treated with a novel therapeutic procedure, using a thirdgeneration osteoconductive, osteogenic and osteoinductive biomaterial. Interproximal connective tissue repair and calcified tissue formation are obtained (AU)


Subject(s)
Humans , Male , Adolescent , Tooth Fractures/therapy , Tooth Root/injuries , Biocompatible Materials , Regenerative Endodontics/methods , Osteogenesis , Root Canal Obturation/instrumentation , Tooth Root/diagnostic imaging , Wound Healing/physiology , Dental Fistula/radiotherapy , Dentition, Permanent
10.
Rev. Ateneo Argent. Odontol ; 64(1): 18-21, 2021. ilus
Article in Spanish | LILACS | ID: biblio-1248258

ABSTRACT

Biomaterial de tercera generación con una tasa de degradabilidad en la zona perirradicular y del foramen apical, con una velocidad similar a la que emplea el organismo para formar tejido calcificado y sellar biológicamente el extremo apical del diente. Mediante el recurso tecnológico de la microencapsulación se produce la liberación lenta y controlada de Ca2+ retenido en la superficie y en el interior de las microesferas de alginato de calcio, sin que se modifique de manera significativa las propiedades reológicas básicas del biomaterial de obturación de conductos, tales como la compresibilidad, plasticidad, extensibilidad, fluidez, viscosidad cinemática, viscosidad de compresión y endurecimiento por trabajo (AU)


Third-generation biomaterial with a degradability rate in the periradicular area and the apical foramen, with a speed similar to that used by the body to form calcified tissue and biologically seal the apical end of the tooth. Through the technological resource of microencapsulation, the slow and controlled release of Ca2+ retained on the surface and inside the calcium alginate microspheres is produced, without significantly modifying the basic rheological properties of the duct sealing biomaterial, such as compressibility, plasticity, extensibility, flowability, kinematic viscosity, compression viscosity, and work hardening (AU)


Subject(s)
Humans , Periapical Diseases/therapy , Root Canal Filling Materials/therapeutic use , Biocompatible Materials , Rheology , Calcium Compounds , Tooth Apex , Drug Compounding , Alginates/chemistry , Microspheres
12.
Rev. Fac. Odontol. (B.Aires) ; 36(82): 43-48, 2021. ilus
Article in Spanish | LILACS | ID: biblio-1291690

ABSTRACT

Las piezas con necrosis pulpar y ápice abierto son un desafío de la práctica clínica endodóntica. Durante mucho tiempo estas piezas han sido tratadas con la técnica de apexificación con hidróxido de calcio. Esta técnica estimula la formación de una barrera calcificada a nivel apical, pero a partir de varias sesiones de tratamiento y los riesgos asociados que esto conlleva. Hoy en día, con el desarrollo de nuevas tecnologías, están a disposición materiales biocerámicos que permiten realizar el protocolo en una sola sesión. El Biodentine es un biocerámico con tiempo de fraguado corto y buena capacidad de sellado, que permite reducir los tiempos clínicos. El objetivo de este trabajo es presentar un caso clínico de una pieza dentaria diagnosticada con necrosis pulpar y con apicoformación incompleta, tratada con una técnica de apexificación con Biodentine en una sesión (AU)


Subject(s)
Humans , Male , Adolescent , Biocompatible Materials , Ceramics , Apexification/methods , Argentina , Schools, Dental , Silicate Cement , Calcium Hydroxide , Clinical Protocols , Dentin
13.
Article in English | WPRIM | ID: wpr-880863

ABSTRACT

Issues caused by maxillofacial tumours involve not only dealing with tumours but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable tumour recurrence, and metastasis are major threats to the patients' lives in the clinic. Fortunately, biomaterial-based intervention can improve the efficiency of tumour treatment and decrease the possibility of recurrence and metastasis, suggesting new promising antitumour therapies. In addition, maxillofacial bone tissue defects caused by tumours and their treatment can negatively affect the physiological and psychological health of patients, and investment in treatment can result in a multitude of burdens to society. Biomaterials are promising options because they have good biocompatibility and bioactive properties for stimulation of bone regeneration. More interestingly, an integrated material regimen that combines tumour therapy with bone repair is a promising treatment option. Herein, we summarized traditional and biomaterial-mediated maxillofacial tumour treatments and analysed biomaterials for bone defect repair. Furthermore, we proposed a promising and superior design of dual-functional biomaterials for simultaneous tumour therapy and bone regeneration to provide a new strategy for managing maxillofacial tumours and improve the quality of life of patients in the future.


Subject(s)
Biocompatible Materials , Bone Regeneration , Bone and Bones , Humans , Quality of Life
14.
Article in Chinese | WPRIM | ID: wpr-880472

ABSTRACT

Silk fibroin has the characteristics of good biocompatibility, mechanical properties, degradation performance and easy shaping, which makes silk fibroin become the focus of biomedical material preparation and research, and has received extensive attention. This article reviews the prior art methods of silk fibroin degumming, dissolution and regeneration processing. The specific applications of silk fibroin materials in the field of biomedical materials are reviewed, and the application prospects of silk fibroin in the field of biomedical materials are prospected.


Subject(s)
Biocompatible Materials , Fibroins
15.
Article in Chinese | WPRIM | ID: wpr-880422

ABSTRACT

It is well known that chitosan-based composites are widely used in implantable medical devices. The development of chitosan-based composite materials with different types was summarized in this paper, such as inorganic, organic and composite phases. Then, combined with the research focus, the development of 3D printing technology and chitosan-based composites was summarized. It was also pointed out that the existing problems in our research, which need to be solved urgently. At last, the development direction and broad application prospect of chitosan-based composites were prospected. And we look forward to providing reference for relevant research.


Subject(s)
Biocompatible Materials , Chitosan , Printing, Three-Dimensional , Prostheses and Implants
16.
Braz. J. Vet. Res. Anim. Sci. (Online) ; 58: e179885, 2021. ilus, graf
Article in English | ID: biblio-1347989

ABSTRACT

Hydroxyapatite, chitosan, and carbon nanotube composite biomaterial were developed to improve bone healing. Previous studies suggested that a combination of biomaterials and mesenchymal stem cells (MSCs) can potentially help promote bone regeneration. In the present study, we first developed hydroxyapatite, chitosan, and carbon nanotube composite biomaterial. Then, the effect of different concentrations of the extract on the viability of Vero cells (ATCC CCL-81) and MSCs obtained from sheep bone marrow using methylthiazol tetrazolium (MTT) and propidium iodide (PI) assays were evaluated. The biomaterial group demonstrated an absence of cytotoxicity, similar to the control group. Samples with 50% and 10% biomaterial extract concentrations showed higher cell viability compared to samples from the control group (MTT assay). These results suggest that the presence of this composite biomaterial can be used with MSCs. This study also concluded that hydroxyapatite, chitosan, and carbon nanotube composite biomaterial were not cytotoxic. Therefore, these could be used for performing in vivo tests.(AU)


O compósito à base de hidroxiapatita, quitosana e nanotubo de carbono foi desenvolvido com o intuito de auxiliar na consolidação óssea. Estudos anteriores sugerem que a combinação de substitutos ósseos e células-tronco mesenquimais (CTM) podem auxiliar a potencializar e promover a regeneração óssea. No presente estudo, o biomaterial foi desenvolvido e a viabilidade e a citotoxicidade de células Vero (ATCC CCL-81) e CTM obtidas de medula óssea provenientes de ovinos utilizando ensaios metil-tiazol-tetrazólio, MTT e iodeto de propídeo (PI) foram avaliadas em diferentes concentrações de extrato desse compósito. O compósito demonstrou ausência de citotoxicidade com comportamento semelhante ao grupo controle. Amostras com 50% e 10% de concentração de extrato do compósito mostraram resultados maiores comparados ao grupo controle (ensaio MTT). Esses resultados também sugerem que a presença do biomaterial pode ser utilizada em associação a CTM. Assim, esse estudo conclui que o compósito apresentado de hidroxiapatita, quitosana e nanotubo de cabono não foi considerado citotóxico e pode ser utilizado em teste in vivo.(AU)


Subject(s)
Animals , Biocompatible Materials , Durapatite , Chitosan , Cytotoxicity, Immunologic , Nanotubes, Carbon , Mesenchymal Stem Cells
17.
Article in Chinese | WPRIM | ID: wpr-878420

ABSTRACT

Oromaxillofacial hard tissue defects is still a difficult problem in clinical treatment. Regeneration of oromaxillofacial hard tissue based on tissue engineering technology has a good clinical application prospect. The functional modification of scaffolds is one of key factors that influence the outcome of tissue regeneration. The biomimetic design of biomaterials through simulating the natural structure and composition of oromaxillofacial hard tissue has gradually become a research hotspot due to its advantages of simplicity and efficiency. In this article, the biomimetic modification of biomaterials for oromaxillofacial hard tissue regeneration is reviewed, expecting to provide a new idea for the treatment of oromaxillofacial hard tissue defect.


Subject(s)
Biocompatible Materials , Biomimetics , Bone Regeneration , Dental Implants , Tissue Engineering , Tissue Scaffolds
18.
Article in Chinese | WPRIM | ID: wpr-879449

ABSTRACT

In the process of repairing of bone defects, bone scaffold materials need to be implanted to restore the corresponding tissue structure at the injury. At present, the repair materials used for bone defects mainly include autogenous bone, allogeneic bone, metal materials, bioceramics, polymer materials and various composite materials. Different materials have demonstrated strong reconstruction ability in bone repair, but the ideal bone implants in the clinic are still yet to be established. Except for autogenous bone, other materials used in bone defect repair are unable to perfectly balance biocompatibility, bone formation, bone conduction and osteoinduction. Combining the latest advances in materials sciences and clinical application, we believe that composite materials supplementedwith Chinese medicine, tissue cells, cytokines, trace elements, etc. and manufactured using advanced technologies such as additive manufacturing technology may have ideal bone repair performance, and may have profound significance in clinical repair of bone defects of special type. This article reviewed to the domestic and foreign literature in recent years, and elaborates the current status of bone defect repair materials in clinical application and basic research in regard to the advantages, clinical options, shortcomings, and how to improve the autogenous bone, allogeneic bone and artificial bone materials, in order to provide a theoretical basis for clinical management of bone defects.


Subject(s)
Acrylic Resins , Biocompatible Materials , Bone Substitutes , Bone and Bones , Osteogenesis , Tissue Engineering , Tissue Scaffolds
19.
Rev. Asoc. Odontol. Argent ; 108(3): 104-112, dic. 2020. ilus, tab
Article in Spanish | LILACS | ID: biblio-1147587

ABSTRACT

Objetivo: Evaluar ex vivo, mediante reconstrucción tridimensional con tomografía computarizada de haz cónico, la presencia de vacíos, el volumen y la adaptación de la obturación a las paredes de conductos con reabsorciones dentinarias internas simuladas empleando gutapercha inyectable o cono único de gutapercha más sellador biocerámico. Materiales y métodos: Se utilizaron 10 incisivos centrales superiores humanos extraídos, en cada uno de los cuales se talló una reabsorción artificial para su obturación. La muestra fue sometida, de manera sucesiva, a dos condiciones experimentales diferentes: grupo 1, gutapercha inyectable con sistema EQ-V Master; grupo 2, cono de gutapercha más sellador biocerámico BioRoot RCS. Luego, se realizaron tomografías computarizadas de haz cónico y se hizo el estudio tridimensional. A continuación, se utilizó un programa para identificar los vacíos en la obturación y analizar cuantitativamente el volumen y la superficie cubierta por la obturación en los tercios coronario, medio (ampolla) y apical. Los datos fueron evaluados con la prueba de Wilcoxon (P<0,05). Resultados: El volumen de obturación y la superficie dentinaria en contacto con la obturación fueron similares para las dos técnicas empleadas. Las diferencias entre ambos grupos no fueron estadísticamente significativas (P>0,05). Conclusión: Aunque se observaron vacíos con ambas técnicas (en contacto con la superficie dentinaria cuando se empleó gutapercha inyectable, y en el interior de la obturación cuando se usó cono único de gutapercha más sellador BioRoot RCS), las dos rellenaron adecuadamente las reabsorciones simuladas (AU)


Aim: Ex vivo, tridimensional evaluation with cone beam computed tomography (CBCT), of the presence of voids, the obturation volume and adaption to the root canal walls with simulated internal root resorption, using injected gutta-percha or bioceramic sealer with single gutta-percha cone. Materials and methods: Ten maxillary extracted central human incisors were used and artificial internal root resorption was created in each one. For the root canal obturation, each tooth was subjected to two different experimental conditions successively, conforming two matched groups: Group I: EQ-V Master injected thermo plasticized gutta-percha system. Group II: gutta- percha point plus BioRoot RCS bioceramic sealer. First, the root canals were filled with injected gutta-percha and then, with the bioceramic sealer. Then the teeth were scanned with CBCT and subsequently a digital three-dimensional reconstruction was performed. The presence of voids, obturation volumne and the dentin wall surface covered by the filling material was quantitative analyzed through a software; at the coronal, middle (blister) and apical thirds. The data was analyzed by using Wilcoxon test (P<0.05). Results: The filling material volume and the dentin wall surface covered by it, was similar in both root canal obturation techniques. There was no significant difference between both groups (P>0.05). Conclusion: Although voids were observed in both groups (when the injected thermo plasticized gutta-percha system was used the voids were at the external surface and when BioRoot RCS + gutta-percha cone was used the voids were into the filling material), the obturation of simulated root canal resorption cavities was similar with both obturation techniques (AU)


Subject(s)
Humans , Root Canal Filling Materials , Biocompatible Materials , Organically Modified Ceramics , Gutta-Percha , Root Resorption , Materials Testing , Statistical Analysis , Imaging, Three-Dimensional , Cone-Beam Computed Tomography
20.
Rev. Asoc. Odontol. Argent ; 108(3): 113-118, dic. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1147645

ABSTRACT

Objetivo: Analizar cualitativamente la biocompatibilidad y la capacidad osteogénica de dos selladores endodónticos a base de silicato de calcio: el biocerámico Bio-C Sealer (BIOc) y MTA Densell Sealer (MTAd). Materiales y métodos: En la tibia izquierda de 30 ratas Wistar macho se implantó un tubo de silicona obturado con BIOc. De igual forma, en la tibia derecha de cada una se implantó un tubo de silicona obturado con MTAd. Los animales fueron eutanasiados en grupos de 10 a los 7, 30 y 90 días. Las tibias fueron procesadas para su análisis histológico y analizadas con microscopía óptica. Según lo observado, fueron clasificadas en tres categorías: 1: Presencia de cápsula fibrosa sana y neoformación ósea, sin células inflamatorias; 2: Cápsula fibrosa con o sin células inflamatorias, formación inicial de trabéculas óseas y presencia de células inflamatorias en los tejidos circundantes; 3: Ausencia de cápsula y/o tejido óseo y presencia de numerosas células inflamatorias. Los resultados fueron analizados con las pruebas de McNemar y de Kruskal-Wallis (P<0,05). Resultados: A los 7 días, los tejidos en contacto con BIOc y MTAd reaccionaron según la categoría 3. A los 30 días, todos los casos correspondieron a la categoría 2. A los 90 días, los 10 implantes de BIOc fueron clasificados según la categoría 1. MTAd presentó nueve casos de categoría 1 y un caso de categoría 2. No hubo diferencias significativas entre ambos selladores dentro de cada uno de los períodos de observación (P>0,05), pero sí las hubo cuando se compararon los resultados obtenidos entre períodos de observación (P<0,05). Conclusión: Al finalizar el ensayo, Bio-C Sealer y MTA Densell Sealer se comportaron como materiales biocompatibles y osteogénicos en tibias de rata (AU)


Aim: To analyze the biocompatibility and osteogenic capacity of two silicate-based endodontic sealers, the bioceramic Bio C-Sealer (BIOc) and the MTA-based sealer MTA Densell (MTAd). Materials and methods: Silicone tubes filled with BIOc were implanted in the left tibias of 30 white male Wistar rats (one per tibia). In similar fashion, tubes filled with MTAd were implanted in the right tibias. The animals were euthanized in groups of 10 at 7, 30 and 90 days postoperatively. The tibias were removed, processed for histology and analysed under optical microscopy. The observations were classified in three categories: 1: Presence of a healthy fibrous capsule and newly formed bone trabeculae without inflammatory cells. 2: Fibrous capsule with or without inflammatory cells, initial formation of bone trabeculae and presence of inflammatory cells in the surrounding tissues. 3: Absence of a fibrous capsule and/or bone formation with the presence of numerous inflammatory cells. Data was analyzed by the McNemar and the Kruskal-Wallis test (P<0.05). Results: At 7 days: The tissues in contact with BIOc and MTAd reacted as category 3. At 30 days: All cases were classified as category 2. At 90 days: All BIOc cases were in category 1 while MTAd presented nine cases of category 1 and one case of category 2. There were no significant differences (P>0.05) between both sealants BIOc and MTAd in each period group. However, there were significant differences (P<0.05) when the results between periods were compared. Conclusion: At the end of the experiment both, BIOc and MTAd behaved as biocompatible and osteogenic materials in the rats' tibias (AU)


Subject(s)
Animals , Rats , Root Canal Filling Materials , Biocompatible Materials , Ceramics , Osteogenesis , Silicones , Materials Testing , Calcarea Silicata , Rats, Wistar , Silicates , Microscopy
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