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1.
Rev. bras. ciênc. vet ; 28(1): 23-29, jan./mar. 2021. il.
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1368354

ABSTRACT

Na procura por material alternativo no tratamento de feridas cutâneas, buscou-se com este estudo avaliar o comportamento da túnica vaginal canina conservada em glicerina a 98% como curativo biológico no tratamento de feridas cutâneas provocadas experimentalmente em ratos. Foram utilizados 16 ratos Wistar, nos quais foram induzidas experimentalmente duas lesões cutâneas na região dorsal, sendo uma cranial e a outra caudal. Uma ferida serviu de controle, a qual não recebeu tratamento, a outra recebeu a túnica vaginal recobrindo toda extensão da lesão. A seleção de qual das feridas, cranial ou caudal, iria receber a membrana foi feita de forma aleatória. Os animais foram distribuídos em quatro grupos de igual número para análises clínicas, macroscópicas e histológicas decorridos três, sete, 14 e 21 dias de pós-operatório. Na avaliação clínica e macroscópica pode-se observar que o processo de reparação teve evolução semelhante tanto no grupo controle quanto no grupo membrana. Na análise histopatológica foi constatada grande quantidade de infiltrado inflamatório nos períodos iniciais, no entanto, decorridos 21 dias, a epiderme já se encontrava reparada, e em todos os momentos foi observada maior presença de tecido conjuntivo no grupo membrana, sugerindo maior precocidade na cicatrização. Deste modo, concluiu-se que a túnica vaginal canina pode ser utilizada como nova alternativa no tratamento de feridas cutâneas.


In the search for alternative material in the treatment of cutaneous wounds, this study aimed to evaluate the behavior of canine vaginal tunic conserved in glycerin 98% as a biological dressing in the treatment of cutaneous wounds provoked experimentally in rats. Sixteen animals were used in which two cutaneous lesions were caused in the dorsal region, one cranial and the other caudal. One wound served as a control which did not receive treatment, the other received the vaginal tunic covering all extension of the lesion. The selection of which of the wounds, cranial or caudal, would receive the membrane was made at random. The animals were divided into four groups of equal numbers for clinical, macroscopic, and histological analyzes after three, seven, 14 and 21 postoperative days. In the clinical and macroscopic evaluation, it can be observed that the healing process had similar evolution in both the control group and the membrane group. In the histopathological analysis, a large amount of inflammatory infiltrate was observed in the initial periods; however, after 21 days the epidermis was already healed, and at all times a greater presence of connective tissue was observed in the membrane group, suggesting a greater precocity in healing. Thus, it was concluded that the canine vaginal tunic can be used as a new alternative in the treatment of cutaneous wounds.


Subject(s)
Animals , Rats , Wound Healing/physiology , Biological Dressings/veterinary , Rats, Wistar/injuries , Wounds and Injuries/therapy , Biocompatible Materials/therapeutic use
2.
Rev. medica electron ; 42(5): 2366-2377, sept.-oct. 2020.
Article in Spanish | LILACS, CUMED | ID: biblio-1144740

ABSTRACT

RESUMEN El material de elección para el reemplazo del hueso perdido por traumatismos, procesos patológicos congénitos o adquiridos y atrofia, son los injertos óseos autógenos o autólogos (hueso del propio paciente). A partir de la introducción del concepto de osteointegración por Branemark, los implantes dentales son parte de la terapéutica diaria para rehabilitar áreas edéntulas. La atrofia alveolar es quizás una de las condiciones bucales más incapacitantes; la razón reside en que es crónica, progresiva, acumulativa e irreversible, altera las relaciones maxilomandibulares, reduce la cantidad de hueso del área dentosoportada y la profundidad del surco. El material de injerto óseo ideal no debería ser sólo un sustituto óseo, sino un material de regeneración que se reabsorba completamente de modo simultáneo a la formación de hueso nuevo. Evaluar el éxito y fracaso de una terapia permite tomar decisiones para un mejoramiento continuo de la práctica clínica. El objetivo de la investigación fue demostrar la importancia de la utilización de biomateriales e injertos óseos autólogos en pacientes con atrofia alveolar (AU).


SUMMARY The elective material for replacing the bone lost by trauma, congenital or acquired pathological processes and atrophy are the autogenic or autologous bone grafts (the patient´s own bones). From the introduction of the concept of osseointegration by Branemark on, dental implants are part of the daily therapeutic for rehabilitating edentulous areas. Alveolar atrophy is perhaps one of the most disabling oral conditions, because it is chronic, progressive, cumulative and irreversible. It alters maxilla-mandibular relations, reduces the bone quality of the dentosupported area and the depth of the sulcus. The ideal bone graft material should not be only a bone substitute, by a regenerative material that could be completely reabsorbed simultaneously with the new bone formation. To assess the success and failure of a therapy allows taking decisions for the continuous improvement of the clinical practice. The aim of the research was to prove the importance of using biomaterials or autologous bone grafts in patients with alveolar atrophy (AU).


Subject(s)
Humans , Male , Female , Periodontal Diseases/therapy , Atrophy/diagnosis , Biocompatible Materials/therapeutic use , Dental Prosthesis/methods , Reconstructive Surgical Procedures , Transplants
3.
Arq. bras. med. vet. zootec. (Online) ; 72(3): 737-743, May-June, 2020. ilus, tab
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1128945

ABSTRACT

Atropelamentos de animais silvestres são frequentes e muitas vezes causam fraturas ósseas que, se não tratadas adequadamente, levam à morte do animal por complicações ou por inabilidade de sobrevivência no seu habitat natural. O objetivo do presente trabalho foi relatar o uso de placa associada ao pino intramedular e ao biovidro 60S (BV60S) para o tratamento de fratura de fêmur em tamanduá-bandeira. O animal foi resgatado pela polícia ambiental com suspeita de atropelamento. Foi sedado para avaliação clínica e radiográfica, que revelou fratura em fêmur direito. Utilizou-se dexmedetomidina como medicação pré-anestésica, midazolam e cetamina para indução, e isoflurano para manutenção. Também foi realizado bloqueio peridural com bupivacaína e morfina. A osteossíntese foi feita com placa bloqueada 2,7 e pino intramedular 2,5. Colocaram-se 4g de BV60S no foco de fratura para favorecer a osteogênese. O paciente teve recuperação funcional imediata do membro acometido. A reparação óssea ocorreu por segunda intenção, observando-se ossificação completa do calo com consolidação clínica, aos 30 dias, e remodelação quase completa, aos 180 dias. Conclui-se que o uso de placa e pino associado ao BV60S é eficiente no tratamento de fratura de fêmur em tamanduá, permitindo a rápida recuperação e a reintrodução do animal na natureza.(AU)


Roadblocks of wild animals are frequent and often cause bone fractures that if not properly treated lead to the death of the animal due to complications or inability to survive in its natural habitat. The objective of the present study was to report the use of plate rod and bioglass 60S (BG60S) for the treatment of femoral fracture in anteater. The animal was rescued by environmental police on suspicion of being hit. It was sedated for clinical and radiographic evaluation, which revealed a fracture in the right femur. Dexmedetomidine was used as preanesthetic medication, midazolam and ketamine for induction, and isoflurane for maintenance. Epidural blockade with bupivacaine and morphine was also performed. Osteosynthesis was done with a locking plate 2.7 and 2.5 intramedullary pin. 4G of BG60S was placed in the focus of fracture to favor osteogenesis. The patient had immediate functional recovery of the affected limb. The bone repair occurred by second intention, with complete ossification of the callus with clinical consolidation at 30 days, and near complete remodeling at 180 days. It is concluded that the use of plate rod to the BG60S is efficient in the treatment of femur fracture in anteater, allowing the rapid recovery and reintroduction of the animal in the wild.(AU)


Subject(s)
Animals , Cingulata/surgery , Femoral Fractures/veterinary , Fracture Fixation, Internal/methods , Fracture Fixation, Internal/veterinary , Osteogenesis/physiology , Biocompatible Materials/therapeutic use , Fractures, Bone , Anesthesia, Conduction/veterinary
4.
Rev. cuba. hematol. inmunol. hemoter ; 35(3): e955, jul.-set. 2019. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1093276

ABSTRACT

Introducción: La principal causa de mortalidad temprana en pacientes politraumatizados es la hipovolemia secundaria a hemorragia masiva. La terapia con hemocomponentes y cristaloides constituye un mecanismo esencial y salvavidas en estas situaciones como medida de reemplazo de volumen. De la misma manera los pacientes con lesiones traumáticas graves tienen una disminución aguda significativa en el recuento de plaquetas circulantes que los hace candidatos a la transfusión de componentes plaquetarios; sin embargo, el uso de estos componentes sanguíneos puede traer consigo desenlaces no deseados como aumento en la mortalidad. Si bien muchos estudios revelan un aumento de la mortalidad como desenlace asociado al uso de hemocomponentes, otros establecen su uso como una medida reductora de este desenlace. Objetivo: Exponer las principales indicaciones de hemocomponentes en los pacientes politraumatizados, así como relacionar los eventos adversos asociados a su uso que influyen sobre la mortalidad y el tiempo de hospitalización de estos pacientes. Desarrollo: La mortalidad asociada al uso de hemocomponentes aún es un tema controvertido. En la hemorragia masiva el apoyo transfusional rápido y eficiente es esencial en el tratamiento y la atención de politraumatismos, de ahí que sea necesario contar con protocolos de transfusión que mejoren los resultados y disminuyan las complicaciones. Además, se identificó la necesidad de nuevos estudios sobre el tema para mejorar estos protocolos y reducir las complicaciones.(AU)


Introduction: The main cause of early mortality in polytrauma patients is hypovolemia secondary to massive hemorrhage. Hemocomponent and crystalloid therapy is an essential and life-saving mechanism in these situations as a measure of volume replacement. In the same way, patients with severe traumatic injuries have a significant acute decrease in circulating platelet counts that makes them candidates for transfusion of platelet components; However, the use of these blood components can lead to unwanted outcomes such as increased mortality. Although many studies reveal an increase in mortality as an outcome associated with the use of blood components, others establish its use as a reducing measure of this outcome. Objective: to present the main indications of blood components in polytrauma patients, as well as to relate the adverse events associated with their use that influence the mortality and hospitalization time of these patients. Devlopment: Mortality associated with the use of blood components is still a controversial issue. In massive hemorrhage, rapid and efficient transfusion support is essential in the treatment and care of polytrauma, hence it is necessary to have transfusion protocols that improve results and reduce complications. In addition, the need for new studies on the subject to improve these protocols and reduce complications was identified(AU)


Subject(s)
Humans , Male , Female , Multiple Trauma/mortality , Multiple Trauma/therapy , Blood Component Transfusion/methods , Biocompatible Materials/therapeutic use , Blood Component Transfusion/adverse effects , Emergency Medicine
5.
Rev. Asoc. Odontol. Argent ; 107(3): 110-115, jul.-sept. 2019.
Article in Spanish | LILACS | ID: biblio-1048552

ABSTRACT

Este trabajo pretende actualizar los conocimientos acerca de los diversos materiales utilizados en las terapias pulpares (tanto en dientes primarios como en permanentes) que buscan una respuesta reparativa cada vez más conservadora, biológica y sustentable. Se trata de un recorrido por el uso de agentes como el agregado de trióxido mineral (MTA), el láser, Biodentine® y los concentrados de plasma rico en plaquetas, con sus características, sus posibles aplicaciones y su eficacia, evaluadas clínica y radiográficamente en múltiples trabajos de investigación, informes de casos, estudios comparativos (in vitro e in vivo) y ensayos experimentales en animales que documentan sus resultados (AU)


This literature review aims to update knowledge about the different materials used in pulp therapies (both in primary and permanent teeth) that seek for an increasingly conservative, biological and sustainable reparative response. It is a journey through the use of agents such as mineral trioxide aggregate (MTA), lasers, biodentine and platelet rich plasma concentrates, their properties, applications and efficacy, clinically and radiographically evaluated in multiple research papers, case reports, comparative studies (in vitro and in vivo) and experimental studies in animals that document their results


Subject(s)
Humans , Animals , Biocompatible Materials/therapeutic use , Dental Pulp/drug effects , Platelet-Rich Plasma , Tooth, Deciduous , Dentition, Permanent , Laser Therapy
6.
Rev. bras. cir. plást ; 34(3): 349-354, jul.-sep. 2019. ilus
Article in English, Portuguese | LILACS | ID: biblio-1047152

ABSTRACT

Introdução: A produção e a distribuição de pele humana pelos Bancos de Pele do Brasil é insuficiente para atender a demanda do país, suprindo menos de 1% da necessidade para tratar as vítimas de queimaduras. O objetivo do trabalho foi apresentar a elaboração e o desenvolvimento da implantação do primeiro Banco de Pele Animal do Brasil para tratamento da queimadura. Métodos: Trata-se de um estudo metodológico. O Banco de Pele Animal Aquático foi elaborado, desenvolvido e instalado a partir do desenvolvimento do processamento de pele da tilápia, da revisão sistemática de estudos referentes a banco de pele animal, de visitas à pscicultura em Jaguaribara-CE, da visita técnica aos bancos de pele humana no Brasil, de consulta técnica e de treinamento no Banco de Pele de Recife, da observação de todas as fases de processamento da pele de tilápia e da identificação da estrutura física da área onde ocorrem todos os processos. Resultados: Além da produção e da distribuição da pele da tilápia para os estudos em vítima de queimaduras, o banco está processando mais de 5000 peles de tilápia e encontra-se em fase de distribuição desta pele para estudos multicêntricos em outros estados e outras especialidades, que desenvolvem pesquisas nas áreas de ginecologia, ortopedia, endoscopia, estomaterapia, cirurgia vascular, odontologia e veterinária. Conclusão: este trabalho possibilitou a elaboração, o desenvolvimento e a implementação do primeiro Banco de Pele Animal do país e o primeiro Banco de Pele Aquática do mundo.


Introduction: The production and distribution of human skin by Brazilian skin banks is insufficient to meet the country's demand, supplying less than 1% of the need for treating burn victims. The objective of this work was to present the elaboration and development of the first animal skin bank of Brazil for the treatment of burns. Methods: This methodological study elaborated, developed, and installed The Aquatic Animal Skin Bank in terms of the development of tilapia skin processing after a systematic review of studies referring to animal skin banks based on visits to the pisciculture center in Jaguaribara-CE, technical visits to human skin banks in Brazil, technical consultation and training in the Recife Skin Bank, the observation of all phases of tilapia skin processing, and the identification of the physical structure of the area where the processes occur. Results: In addition to the production and distribution of tilapia skin for studies on burn victims, the bank is processing more than 5000 tilapia skin samples and is in the distribution phase of this skin for multicentric studies in other states and specialties including gynecology, orthopedics, endoscopy, stomatherapy, vascular surgery, dentistry, and veterinary medicine. Conclusion: This work enabled the elaboration, development, and implementation of Brazil's first animal skin bank and the world's first aquatic skin bank.


Subject(s)
Animals , History, 21st Century , Biocompatible Materials , Biocompatible Materials/therapeutic use , Biological Dressings , Burns , Tilapia , Skin, Artificial , Cichlids , Fisheries , Biocompatible Materials/analysis , Biological Dressings/standards , Biological Dressings/supply & distribution , Burns/rehabilitation , Tilapia/surgery , Skin, Artificial/standards , Cichlids/surgery , Fisheries/standards
7.
Arq. bras. med. vet. zootec. (Online) ; 71(4): 1121-1130, jul.-ago. 2019. graf, ilus
Article in Portuguese | LILACS, VETINDEX | ID: biblio-1038624

ABSTRACT

O objetivo do estudo foi avaliar o efeito da matriz porosa do biovidro 60S (BV60S) associada a células osteoprogenitoras (CO) alógenas no tratamento de defeitos ósseos críticos de cães. Foram utilizados 20 cães, machos, sem raça definida, com dois anos de idade e massa corporal média de 25kg. Com os cães sob anestesia geral, foram criados defeitos ósseos críticos no terço médio dos ossos rádios. Procedeu-se à fixação óssea com uma placa em ponte, e os defeitos foram tratados de acordo com cada grupo experimental. Constituíram-se três grupos experimentais, em que os defeitos ósseos foram preenchidos com: BV60S associado a CO alógenas (grupo BV60S+CO), osso autógeno (grupo C+), ou não preenchidos (grupo C-). A regeneração óssea foi avaliada por meio de exames radiográficos, densitométricos e histomorfométricos ao longo de 90 dias. Os grupos C- e BV60S+CO mostraram preenchimento ósseo parcial do defeito de, no máximo, 56,68% e 35,23%, respectivamente, sem a formação de ponte óssea entre as extremidades, e o controle positivo (C+) mostrou regeneração óssea completa. Conclui-se que a matriz porosa do BV60S associada às células osteoprogenitoras não é eficiente no tratamento de defeitos ósseos críticos em rádios de cães.(AU)


The objective of this study was to evaluate the effect of the porous matrix of bioglass 60S (BV60S) associated with allogenic osteoprogenitor cells (CO) in the treatment of critical bone defects of dogs. 20 male mongrel dogs at two years old and mean weight of 25kg were used. Dogs were anesthetized and critical bone defects were created in the middle third of the radios bones. With dogs under general anesthesia, critical bone defects were created in the middle third of bone radios. Bone fixation was done with a bridge plate and defects treated according to each experimental group. Three experimental groups were formed according to the treatment. The defects filled with BV60S associated with allogenic CO (Group-BV60S+CO), autogenous bone (Group-C+) or unfilled (Group-C-). Bone regeneration was evaluated by radiography, bone densitometry and histomorphometry over 90 days. The BV60S+CO and C- groups showed partial bone filling of the defect of at most 56.68% and 35.23%, respectively. No bone bridge formation was observed between the extremities in the BV60S+CO and C- groups. Positive control showed complete bone regeneration at 90 days. It was concluded that the porous matrix of BV60S associated with osteoprogenitor cells was not effective in the treatment of critical bone defects in the radius of dogs.(AU)


Subject(s)
Animals , Dogs , Radius/injuries , Biocompatible Materials/therapeutic use , Bone Regeneration , Cell- and Tissue-Based Therapy/methods , Cell- and Tissue-Based Therapy/veterinary
8.
Arq. bras. med. vet. zootec. (Online) ; 71(3): 811-818, May-June 2019. tab, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1011292

ABSTRACT

Trauma or disease inflicted by tissue injuries may cause tissue degeneration. The use of biomaterials for direct or indirect repair has emerged as a promising alternative, and has become an important research topic. The pequi fruit (Caryocar brasiliense Camb.) has shown antifungal, antibacterial, anti-inflammatory, healing, antitumor, and antioxidant properties. The objective of this study was to develop a new biomaterial using a combination of collagen, gelatin, and pulp pequi oil, and to evaluate its biocompatibility in comparison with that of biomaterials produced without pulp pequi oil. Membranes were prepared from a mixture of bovine tendon collagen, commercial gelatin, and pulp pequi oil. The inflammatory and cicatricial processes were assessed via histopathology of the tissue interface/implants in the subcutaneous tissues and quantitative evaluation of leukocyte and collagen production in Wistar rats. It was observed that the presence of pequi oil reduced the amount of foreign-body giant cells and favored the recruitment of fibroblasts (P< 0.01), thereby promoting greater production of collagen membrane than that in the membranes of control samples. Therefore, it can be concluded that the addition of pequi oil improved the biocompatibility of collagen and accelerated the healing process.(AU)


Trauma ou lesões causadas por doenças podem enfraquecer e degenerar os tecidos humanos e animais. O uso de biomateriais para reparação direta ou indireta surgiu como uma alternativa promissora e tornou-se um importante tema de pesquisa. O óleo de pequi (Caryocar brasiliense Camb.) mostrou propriedades antifúngicas, antibacterianas, anti-inflamatórias, curativas, antitumorais e antioxidantes. O objetivo deste estudo foi obter um novo biomaterial, produzido pela combinação de óleo de pequi, colágeno e gelatina, para avaliar sua biocompatibilidade em comparação às membranas produzidas sem o óleo. As membranas foram preparadas por meio da mistura de colágeno de tendão bovino, gelatina comercial e óleo de pequi. Os processos inflamatórios e cicatriciais foram avaliados por histopatologia da interface / implantes de tecido subcutâneo de ratos Wistar para avaliação quantitativa da produção de leucócitos e colágeno. Observou-se que a presença de óleo de pequi reduziu a quantidade de células gigantes de corpo estranho e favoreceu o recrutamento de fibroblastos (P<0,01), promovendo, assim, maior produção da membrana de colágeno em comparação com a membrana de controle. Portanto, pode-se concluir que a adição de óleo de pequi melhorou a biocompatibilidade do colágeno e acelerou o processo de cicatrização.(AU)


Subject(s)
Animals , Rats , Biocompatible Materials/therapeutic use , Soft Tissue Injuries/veterinary , Ericales , Wound Healing , Collagen/therapeutic use , Gelatin/therapeutic use
9.
J. oral res. (Impresa) ; 7(8): 382-386, nov. 30, 2018. ilus
Article in English | LILACS | ID: biblio-1121119

ABSTRACT

Chronic pulpal inflammation and infection are the main predisposing factors for internal and external root resorption (IRR & ERR); however, merging of IRR and ERR is a rare lesion which rigorously alters the anatomy of root canals. this study reports a case of merged IRR and ERR in an asymptomatic maxillary left central incisor in a 33-year old caucasian woman that was managed by one-visit root canal therapy (RCT) using calcium-enriched mixture (CEM) cement. radiographic examination showed a short root with under-filled root canal obturation associated with ERR/IRR and an apical lesion. after thorough chemo-mechanical preparation, the root canal was obturated with CEM cement; one week later, the access cavity was permanently restored. clinical/radiographic examinations at 1-year follow-up revealed uneventful healing, reestablishment of lamina dura and stabilization of the resorptive defects. the treatment outcome demonstrates that one-visit RCT using CEM cement may be a viable treatment option in cases with merged external/internal root resorption. further clinical trials with a larger number of cases are suggested to document a higher level of evidence.


Subject(s)
Humans , Female , Adult , Periapical Diseases/therapy , Root Canal Filling Materials/therapeutic use , Root Canal Therapy/methods , Root Canal Obturation/methods , Biocompatible Materials/therapeutic use , Calcium/therapeutic use , Dental Pulp Necrosis , Molar/pathology
10.
Acta cir. bras ; 33(8): 673-683, Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-949378

ABSTRACT

Abstract Purpose: To evaluate the efficacy of the cellulosic exopolysaccharide membrane (CEM) as a urethral reinforcement for urethrovesical anastomosis. Methods: Twenty eight rabbits were submitted to urethrovesical anastomosis with or without CEM reinforcement. The animals were divided into 4 groups: C7, CEM7, C14 and CEM14: (C= only anastomosis or CEM = anastomosis + CEM), evaluated after 7 weeks, and 14 weeks. The biointegration and biocompatibility of CEM were evaluated according to stenosis, fistula, urethral wall thickness, urethral epithelium, rate of inflammation and vascularization. Results: Between the two experimental groups, the difference in the number of stenosis or urinary fistula was not statistically significant. The morphometric analysis revealed preservation of urethral lumen, well adhered CEM without extrusion, a controlled inflammatory process and implant vascularization. The urothelium height remained constant over time after CEM reinforcement and the membrane wall was thicker, statistically, after 14 weeks. Conclusion: The absence of extrusion, stenosis or urinary fistula after 14 weeks of urethrovesical anastomosis demonstrates cellulosic exopolysaccharide membrane biocompatibility and biointegration with tendency to a thicker wall.


Subject(s)
Animals , Male , Rabbits , Urethra/surgery , Biocompatible Materials/therapeutic use , Urinary Bladder/surgery , Cellulose/therapeutic use , Polysaccharides, Bacterial/therapeutic use , Time Factors , Urethra/pathology , Urinary Bladder/pathology , Industrial Microbiology/methods , Materials Testing , Anastomosis, Surgical , Cellulose/biosynthesis , Reproducibility of Results , Treatment Outcome , Translational Medical Research , Neovascularization, Pathologic
11.
Braz. J. Vet. Res. Anim. Sci. (Online) ; 55(2): 138489, 26 jul. 2018. ilus
Article in English | LILACS, VETINDEX | ID: biblio-913473

ABSTRACT

The use of alternative therapeutic approaches in wild animals has gained notoriety due to its efficiency, low cost and reduced or nonexistent stressors. The present study evaluated the efficacy of treatment of a bilateral excoriative lesion in the region of the dorsal metacarpus in a Chilean skua (Catharacta chilensis) in a rehabilitation process with the use of a porous cell membrane, sold commercially, in concomitance with moxibustion sessions with herbs (Artemisia vulgaris). The healing time of 14 days was reduced when compared to traditional techniques and proved the viability and efficacy of the treatment.(AU)


O uso de abordagens terapêuticas alternativas em animais selvagens tem ganhado notoriedade em virtude de sua eficiência, baixo custo e estímulos estressores reduzidos ou inexistentes. Este estudo avaliou a eficácia do tratamento de uma lesão escoriativa bilateral em região do dorsal metacarpo em um mandrião chileno (Catharacta chilensis) em processo de reabilitação com o uso de uma membrana celular porosa vendida comercialmente, em concomitância com sessões de moxabustão com ervas (Artemisia vulgaris). O tempo de cicatrização de catorze dias mostrou-se reduzido quando comparado ao de outras técnicas tradicionais e provou a viabilidade e eficácia do tratamento.(AU)


Subject(s)
Animals , Artemisia , Biocompatible Materials/therapeutic use , Birds/injuries , Metacarpus/injuries , Moxibustion/veterinary , Wound Healing , Marine Fauna
12.
Int. braz. j. urol ; 44(3): 585-590, May-June 2018. tab, graf
Article in English | LILACS | ID: biblio-954059

ABSTRACT

ABSTRACT Introduction: Durasphere® EXP (DEXP) is a compound of biocompatible and non--biodegradable particles of zirconium oxide covered with pyrolytic carbon. The aim of this study is to evaluate the durability of off-label use of DEXP in the treatment of primary vesicoureteral reflux in children. Materials and Methods: Patients who underwent subureteric injection of DEXP for the correction of primary VUR were retrospectively reviewed. Patients aged >18 years as well as those who had grade-I or -V VUR, anatomic abnormalities (duplicated system, hutch diverticulum), neurogenic bladder or treatment refractory voiding dysfunction were excluded. Radiologic success was defined as the resolution of VUR at the 3rd month control. Success was radiographically evaluated at the end of the first year. Results: Thirty-eight patients (9 boys, 29 girls; mean age, 6.3±2.7 years) formed the study cohort. Forty-six renal units received DEXP (grade II: 22; grade III: 18; grade IV: 6). Mean volume per ureteric orifice to obtain the mound was 0.70±0.16mL. First con- trol VCUG was done after 3 months in all patients. After the first VCUG, 6 patients had VUR recurrence. Short-term radiologic success of DEXP was 84.2%. Rate of radiologic success at the end of the first year was 69.4% (25/32). Lower age (p:0.006) and lower amount of injected material (p:0.05) were associated with higher success rates at the end of 1 year. Conclusion: This is the first study to assess the outcomes of DEXP for treatment of primary VUR in children. After 1 year of follow-up, DEXP had a 69.4% success rate.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Vesico-Ureteral Reflux/drug therapy , Zirconium/therapeutic use , Biocompatible Materials/therapeutic use , Glucans/therapeutic use , Recurrence , Vesico-Ureteral Reflux/surgery , Severity of Illness Index , Reproducibility of Results , Retrospective Studies , Dextrans/therapeutic use , Treatment Outcome , Statistics, Nonparametric , Endoscopy/methods , Hyaluronic Acid/therapeutic use , Injections
13.
ImplantNewsPerio ; 3(3): 463-472, mai.-jun. 2018. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-905505

ABSTRACT

Objetivos: avaliar o aumento ósseo com um biomaterial aloplástico no seio maxilar. Materiais e métodos: foram selecionados seis pacientes, totalizando nove seios maxilares, que realizaram cirurgia de reconstrução óssea em região posterior de maxila. Todas as cirurgias de elevação do seio maxilar traumáticas utilizaram o biomaterial sintético Straumann Bone Ceramic. Os pacientes realizaram uma tomografia pré-operatória, e uma após seis meses do ato cirúrgico, em que foram obtidas medidas lineares horizontais e verticais na imagem panorâmica da tomografia e medidas lineares horizontais e verticais no corte sagital da tomografia, ambas no centro das imagens. Resultados: identificou-se 100% de sucesso nas cirurgias de elevação de seio maxilar, em que verticalmente obteve-se diferença estatística significante (p < 0,05) e horizontalmente sem significância estatística (p > 0,05). Em média, obteve-se ganho vertical ósseo de 14,73 mm na imagem panorâmica e 16,05 mm no corte sagital, e espessura 20,82 mm na imagem panorâmica e 11,37 mm no corte sagital. Conclusão: o biomaterial sintético Straumann Bone Ceramic demonstrou-se excelente para a reconstrução de seios maxilares.


Objectives: to evaluate bone augmentation using an alloplastic material. Material and methods: six patients (9 maxillary sinuses) underwent surgical bone reconstruction at the posterior maxillary region. All surgeries were performed after atraumatic sinus membrane lifting and packing of Straumann BoneCeramic. Also, CBCTs were made at baseline and 6 months later to generate horizontal and vertical measurements at the panoramic and sagittal view modes both at the center of the images. Results: operative procedures were considered 100% successful. At the vertical dimension, statistical differences were obtained (p<0.05) but no significant differences were seen in the horizontal dimension (p>0.05). Overall, the vertical mean gain was 14.73mm at the panoramic and 16.05mm at the sagittal sections, being the observed thicknesses of 20.82mm and 11.37mm, respectively. Conclusion: the Straumann BoneCeramic biomaterial provided excellent results for maxillary sinus reconstructions.


Subject(s)
Humans , Biocompatible Materials/therapeutic use , Bone Regeneration , Bone Substitutes/therapeutic use , Bone Transplantation/methods , Cone-Beam Computed Tomography , Maxillary Sinus/surgery , Sinus Floor Augmentation
14.
ImplantNewsPerio ; 3(3): 485-490, mai.-jun. 2018.
Article in Portuguese | LILACS, BBO | ID: biblio-905512

ABSTRACT

O desvio de septo nasal, concha bolhosa e a obstrução do óstio são alterações do complexo osteomeatal, que podem interferir no volume dos seios maxilares, em sua oxigenação, drenagem adequada de fluidos e nos resultados de cirurgias nessa região. A adoção de um protocolo de avaliação do complexo osteomeatal envolvendo uma equipe multidisciplinar no planejamento de cirurgias de levantamento de seio maxilar pode proporcionar a diminuição do surgimento de complicações pós-operatórias relacionadas à drenagem e ventilação, prejudicadas pelo desvio de septo nasal, concha bolhosa e obstrução do óstio.


Nasal septum deviation, concha bullosa and ostium obstruction are alterations of the osteomeatal complex that may interfere with the volume of the maxillary sinuses, their oxygenation, adequate drainage of fluids and the results of surgeries in this region. The adoption of a protocol for evaluation of the osteomeatal complex involving a multidisciplinary team in the planning of surgeries of maxillary sinus can provide a reduction in the appearance of postoperative complications related to drainage and ventilation impaired by nasal septum deviation, concha bullosa and obstruction of the ostium.


Subject(s)
Humans , Male , Female , Biocompatible Materials/therapeutic use , Maxillary Sinus/anatomy & histology , Nasal Septum/abnormalities , Sinus Floor Augmentation
15.
Rev. inf. cient ; 97(supl.2): 439-447, 2018.
Article in Spanish | LILACS, CUMED | ID: biblio-999316

ABSTRACT

Se realizó un estudio cuasi experimental, longitudinal y prospectivo, con el objetivo de evaluar el tratamiento de los defectos óseos complejos con coralina y membrana de colágeno. El universo estuvo constituido por 18 pacientes de ambos sexos entre 25 y 54 años de edad atendidos en la Clínica "Lidia Doce Sánchez" de Guantánamo desde 2014 hasta 2017. Los pacientes se distribuyeron según grupos de edades, fueron evaluados luego del año de ser intervenidos. Se evidenció mayoritariamente el grupo de edades de 35-44 años, la ausencia de bolsas periodontales, la movilidad dentaria grado 0. La osteointegración grado III y una evaluación buena del tratamiento con coralina y membrana de colágeno en defectos óseos complejos, coincidieron en primacía(AU)


A quasi-experimental, longitudinal and prospective study was carried out, with the aim of evaluating the treatment of complex bone defects with coralina and collagen membrane. The universe consisted of 18 patients of both sexes between 25 and 54 years of age attended in the Clinic "Lidia Doce Sánchez" of Guantanamo from 2014 to 2017. The patients were distributed according to age groups, were evaluated after the being operated. The age group of 35-44 years, the absence of periodontal pockets, the grade 0 tooth mobility were evidenced. The osseo integration grade III and a good evaluation of the treatment with coralina and collagen membrane in complex bone defects coincided in primacy(AU)


Subject(s)
Humans , Adult , Periodontitis/diagnosis , Periodontitis/therapy , Biocompatible Materials/therapeutic use , Collagen/therapeutic use , Prospective Studies , Longitudinal Studies , Non-Randomized Controlled Trials as Topic
16.
Braz. j. med. biol. res ; 51(10): e7380, 2018. tab, graf
Article in English | LILACS | ID: biblio-951717

ABSTRACT

The aim of this study was to discuss the curative effect of applying "capsule-reserved normal saline bag and self-made hemi-spherical cushion oppression" for treating giant omphaloceles. Twelve patients with giant omphaloceles who were admitted to our hospital between January 2008 and June 2016 were selected for treatment as follows: a capsule-reserved normal saline bag was used to promote the gradual return of the abdominal contents into the abdominal cavity in phase I, and a self-made hemi-spherical cushion was used for compression combined with a local dressing change in phase II to treat the giant omphaloceles without surgical treatment. All 12 patients in this group were cured, and after follow-up visits for >10 months, they had no abdominal infections, wound disruption, intestinal obstruction, or other complications, and their growth was normal. Two patients had abdominal hernias, and they recovered after herniorrhaphies. Giant omphaloceles in newborns were treated in stages, and in phase II, non-surgical treatment was applied, which was easily performed with a smaller wound, low cost, an obvious curative effect, and higher safety and effectiveness.


Subject(s)
Humans , Male , Female , Infant, Newborn , Bandages , Biocompatible Materials/therapeutic use , Hernia, Umbilical/therapy , Time Factors , Severity of Illness Index , Follow-Up Studies , Treatment Outcome
17.
Rev. habanera cienc. méd ; 16(4): 586-594, jul.-ago. 2017. ilus
Article in Spanish | LILACS, CUMED | ID: biblio-901751

ABSTRACT

IIntroducción Las lesiones endoperiodontales son aquellas de carácter inflamatorio que comprometen simultáneamente la pulpa dental y las estructuras del periodonto de inserción, donde se obtiene un pronóstico favorable solo cuando el diente está en un ambiente cerrado y protegido, y se alcanza la cronicidad del componente periodontal de la afección. Para lo cual el uso de los biomateriales y el esquema operatorio tienen un carácter crucial. Objetivo: Describir un caso de restauración endodóntica avanzada por vía directa, con el uso de MTA. Presentación del caso:Paciente de 45 años, masculino, quien acude a consulta presentando una lesión endoperiodontal combinada con toma del fulcron en (46). El mismo requirió una radiculectomía, reconstrucción de corona y raíz por vía directa, y estabilización a través del uso del Agregado Trióxido Mineral (MTA). Conclusiones:La aplicación del MTA en la restauración endodóntica avanzada combinada con el composite nano híbrido por vía directa es una alternativa factible de realizar en una sola visita, y garantiza una rápida recuperación de las funciones buco-dentales del paciente(AU)


Introduction: Endoperiodontal lesions are those lesions that have an inflammatory character that simultaneously compromise the dental pulp and periodontal structures of insertion, where favorable prognosis is obtained only when the tooth is in a closed and protected environment, and the chronicity of the periodontal component is achieved. Consequently, the use of biomaterials and the operative scheme have a crucial character. Objective: To describe a case of advanced endodontic restoration by direct placement of MTA. Case presentation: 45 years old patient who comes to the consultation presenting a combined endoperiodontal lesion, reaching the fulcron in (46). The patient required a radiculectomy, a direct reconstruction of the crown and the root, and stability through the use of Mineral Trioxide Aggregate(MTA). Conclusions: The direct placement of MTA in an advanced endodontic restoration, combined with the nano-hybrid material is an alternative that is viable to do in a single visit and guarantees a fast recovery of the buccal-dental functions of the patient(AU)


Subject(s)
Humans , Middle Aged , Root Canal Filling Materials/standards , Dental Cements/therapeutic use , Dental Restoration, Permanent/methods , Periodontics/methods , Biocompatible Materials/therapeutic use
18.
Actual. osteol ; 13(2): 116-124, Mayo - Ago. 2017. ilus, tab
Article in English | LILACS | ID: biblio-1117997

ABSTRACT

To prevent post-extraction resorption and preserve the integrity of the alveolar ridges, the placement of bone grafts at the time of extraction is recommended. Bovine bone grafts are biocompatibile and osteoconductive, allowing new bone apposition by osteoprogenitor cells. Although there are trademarks recognized internationally regarding bovine bone grafts, they are expensive and even difficult to acquire. Therefore, domestic industry development of high quality biomaterials will reduce the public health high costs in the dental field. Here, we evaluated and compared the effects of an Argentinean manufactured bovine bone graft (Synergy Bone Matrix) with a bovine bone graft recognized for its osteoconductive effects (Bio-Oss), on bone healing in an experimental model in rats. We created critical sized bone defects in rat tibiae and filled them with either one of the bovine bone grafts or control. Clinical responses, X-ray findings, bone mineral density, and histological parameters were evaluated. No abscess, encapsulation, suppuration or inflammation of lymphatic nodes were observed. Radiographically, all implants were amalgamated to the surrounding bony margins, suggesting proper healing. On the other hand, control tibiae exhibited no signs of recovery and remained either unfilled or showed fibrous tissue formation. No statistical differences were observed in BMC and BMD between tibiae filled with Synergy Bone Matrix or Bio-Oss. Histological analysis revealed particles of both bone grafts surrounded by laminar bone tissue indicating osteoconductivity, without any inflammatory sign. This preliminary study suggests that Synergy Bone Matrix, as well as Bio-Oss, present similar properties of biocompatibility and osteoconductivity. (AU)


Para prevenir la resorción post-exodoncia y preservar la integridad de los rebordes alveolares, se recomienda la colocación de injertos óseos en el momento de la extracción. Los injertos de hueso bovino son biocompatibles y osteoconductivos, permitiendo nueva aposición ósea por células osteoprogenitoras. Existen marcas internacionales de injertos de hueso bovino, pero resultan caros e incluso difíciles de adquirir. Por ello, la elaboración de biomateriales de alta calidad, nacionales, reduciría los altos costos de salud pública en odontología. En este estudio, se evaluaron y compararon los efectos de un injerto de hueso bovino fabricado en Argentina (Synergy Bone Matrix) versus un injerto de hueso bovino reconocido por sus efectos osteoconductivos (Bio-Oss), en el proceso de cicatrización ósea en un modelo experimental en ratas. Para ello, creamos un defecto óseo crítico en tibia de rata el cual se rellenó con uno de los injertos de hueso bovino o control. Se evaluó: respuesta clínica y radiográfica, densidad mineral ósea e histología. No se observaron abscesos, encapsulación, supuración o inflamación de los ganglios linfáticos. Radiográficamente, todos los implantes se integraron a los márgenes óseos circundantes, sugiriendo una cicatrización adecuada. Por el contrario, las tibias control no mostraron signos de recuperación con formación de tejido fibroso. No se observaron diferencias estadísticas en las BMC y BMD entre las tibias Synergy Bone Matrix o Bio-Oss. La histología reveló partículas de ambos injertos óseos rodeadas por tejido óseo laminar indicando osteoconductividad sin signos inflamatorios. Este estudio preliminar sugiere que Synergy Bone Matrix presenta propiedades similares de biocompatibilidad y osteoconductividad que Bio-Oss. (AU)


Subject(s)
Animals , Rats , Tibia/cytology , Biocompatible Materials/therapeutic use , Bone Resorption/prevention & control , Bone Transplantation/veterinary , Argentina , Radiology , Surgery, Oral , Bone Development , Bone Diseases, Developmental/chemically induced , Bone Diseases, Developmental/diagnostic imaging , Bone Density , Bone Transplantation/rehabilitation , Rats, Wistar/anatomy & histology , Rats, Wistar/surgery , Ketamine/administration & dosage , Acepromazine/administration & dosage , Lymph Nodes/diagnostic imaging
19.
Arq. bras. med. vet. zootec. (Online) ; 69(4): 973-979, jul.-ago. 2017. ilus
Article in Portuguese | LILACS, VETINDEX | ID: biblio-876721

ABSTRACT

O objetivo deste trabalho é avaliar o uso da túnica albugínea suína na cistoplastia em ratos, avaliando funcionalidade, capacidade de reparação do órgão e possibilidades de complicações. Foram selecionados 30 ratos Wistar, machos, de seis meses de idade, divididos em: um grupo teste (TA), em que os animais receberam o enxerto de túnica albugínea suína após a cistectomia parcial e um grupo controle (C), em que os animais sofreram somente a cistectomia parcial. Os animais pertencentes a ambos os grupos foram divididos igualmente em subgrupos de cinco animais cada, que sofreram eutanásia em sete, 28 e 42 dias de pós-operatório. Foi realizada uma análise macroscópica e, posteriormente, uma análise histopatológica da região da ferida cirúrgica. Aos sete e 28 dias, os animais pertencentes ao grupo C e ao grupo TA apresentaram urotelização, regeneração da lâmina própria e da musculatura, porém o grupo TA apresentou menores sinais inflamatórios e maior organização tecidual, principalmente com relação à formação das fibras musculares. Aos 42 dias de pós-operatório, ambos os grupos já apresentavam características histológicas normais. Concluiu-se que o enxerto de túnica albugínea suína obteve sucesso na regeneração da bexiga de ratos, mantendo a funcionalidade do órgão, sem rejeição, e favorecendo a migração celular.(AU)


The aim of this study is to evaluate porcine tunica albuginea as a graft for cystoplasty in rats, regarding bladder function, capacity and possible complications. 30 male Wistar rats with six monthes of age have been selected and separated into two different groups: A test group (TA) in which the animals received a tunica albuginea graft after partial cystectomy and a control group (C) in which partial cystectomy was performed, followed by bladder suture. In each group the animals were euthanized at seven, 28 and 42 days after surgery. Macroscopic and Histological analysis have been performed. At seven and 28 days after surgery the samples from both groups had urothelial lining upon a lamina propria and smooth muscle fibers in regeneration process. However, the TA group showed less inflammatory signs and more organized structure, mainly regarding the smooth muscle formation. At 42 days after surgery all groups showed a bladder wall structure qualitatively identical to the normal tissue. We could conclude that tunica albuginea graft is able to maintain bladder function and support cellular migration without any kind of rejection.(AU)


Subject(s)
Animals , Male , Rats , Biocompatible Materials/therapeutic use , Cystectomy/veterinary , Heterografts , Urinary Bladder/transplantation
20.
Actas odontol ; 14(1): 4-13, jul. 2017. tab, ilus
Article in Spanish | LILACS, BNUY | ID: biblio-982601

ABSTRACT

Con el advenimiento de los materiales Bioactivos hoy hay un cambio de paradigma en el tratamiento de la protección pulpar directa. Está ampliamente demostrado en la literatura tanto en los estudios in vitro como in vivo, que estos materiales son más efectivos que el hidróxido de calcio para lograr cambios biológicos y microestructurales en el tejido pulpar y dentinario. Es así que surgen los materiales bioactivos, los cuales son sustancias que al ponerse en contacto con los tejidos vivos, provocan un efecto positivo sobre los mismos formando tejidos calcificados. Inducen una respuesta biológica específica en la interfase material-tejido. Actualmente los que cuentan con mayor aval científico son: MTA, Biodentine y Theracal LC.


Nowadays with the arrival of the Bioactive Materials, there has been an important change in the treatment of direct pulp capping. It is already probed, in studies in vitro and in vivo that these materials are more effective than calcium hydroxide as they obtain biological and microstructural changes in the pulpar and dentinal tissues.That is the reason for the appearance of the BIOACTIVE materials, which cause a specific biological response in the interface material-tissue when they are in contact with the vital tissues. The actual materials with the best scientific acceptance are: MTA, Biodentine and Theracal.


Subject(s)
Humans , Biocompatible Materials/analysis , Biocompatible Materials/therapeutic use , Dental Pulp Capping/methods , Pulp Capping and Pulpectomy Agents/therapeutic use , Dental Materials , Dental Pulp Exposure/therapy
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