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3.
Rev. bras. med. fam. comunidade ; 16(Suplemento 1 - 40 anos da SBMFC e 45 anos da especialidade no Brasil): 3249, 20211203.
Article in English, Spanish, Portuguese | LILACS | ID: biblio-1358573

ABSTRACT

No ano que marca os 40 anos da Sociedade Brasileira de Medicina de Família e Comunidade (SBMFC) e os 45 anos da Medicina de Família e Comunidade (MCF) como especialidade no Brasil, este artigo traz ­ por meio de entrevistas ­ pensamentos e percepções sobre Programas de residência em MFC e a participação desta especialidade em cursos de graduação, pesquisa e gestão em saúde. Esses entrevistados representam o passado, presente e futuro da FCM e da SBMFC [1]. Sua história se confunde com a da SBMFC e da FCM nestes 40/45 anos, considerando alguns cargos ocupados por esses profissionais na FCM e na SBMFC nesse período. Sua relação com a FCM e a SBMFC pode ser encontrada no Editorial desta edição comemorativa. As entrevistas exploram aspectos relacionados aos desafios, avanços e perspectivas da MFC e da SBMFC no processo de qualificação docente, de ampliação do número de especialistas e de ampliação da formação em pesquisa e gestão na área de MFC e atenção primária à saúde (APS).


Subject(s)
Education, Higher , Biomedical Research , Health Human Resource Training , Family Practice
4.
Rev. psiquiatr. Urug ; 85(1): 63-76, oct. 2021.
Article in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1343170

ABSTRACT

Los psicodélicos son sustancias capaces de alterar la conciencia, a través de su efecto sobre la transmisión serotoninérgica en el sistema nervioso central. En sus formas de ingesta tradicional son utilizados en rituales, con fines espirituales y medicinales. En el campo científico, dichas sustancias fueron estudiadas para posibles aplicaciones psicoterapéuticas en el período 1950-1970, y luego fueron excluidas de la investigación clínica durante las posteriores décadas. Sin embargo, desde 1990 asistimos a un «renacimiento de los estudios sobre psicodélicos¼, donde estas sustancias están siendo estudiadas en su potencial clínico para el tratamiento de distintos trastornos menta-les. El presente artículo describe y reflexiona sobre la historia de estas investigaciones en Uruguay y en el mundo, tanto en su primera etapa (1950-1970) como en su renacimiento posterior (1990-actualidad), dejando planteado un escenario en el que sea posible avanzar en el campo de las investigaciones clínicas con psicodélicos en nuestro país.


Psychedelics are substances capable of altering consciousness, through their effect on serotonergic transmission within the central nervous system. In their traditional uses, psychedelics are consumed during rituals, for spiritual and medicinal purposes. In the scientific field, these substances were studied because of their possible psychotherapeutic applications in the period 1950-1970. Afterwards, psychedelics were banned from clinical research for decades. Nevertheless, since 1990 we are witnessing a "renaissance of psychedelic studies", where these substances are being studied because of their clinical potential applications for the treatment of different mental disorders. The current article describes and analyzes the history of these research in Uruguay and in the world, both in its first stage (1950-1970) and in the present "renaissance" (1990-present). The article suggests a future scenario, where Uruguay could play a major role in the field of psychedelic research.


Subject(s)
Humans , Biomedical Research/trends , Hallucinogens/history , Mental Disorders/drug therapy , Uruguay
6.
Ciênc. Saúde Colet ; 26(8): 3199-3208, ago. 2021. tab, graf
Article in English | LILACS | ID: biblio-1285952

ABSTRACT

Abstract The lack of knowledge in the biomedical literature regarding the validity of qualitative studies might be related to the lower number of qualitative studies that have been published. The criticisms range from a lack of theoretical depth to the superficial discussions of empirical findings. The aim of this study was to explore the bibliometric entities and the trends in the structure of qualitative research in the biomedical literature. A bibliometric analysis and mapping of the biomedical literature were used. The number of studies selected was 1,725. The heath themes with the most publications included Health Management (12%) and Women's Health (9.8%), while the authors of the studies had academic affiliation in 76 different countries. The sample sizes were between 11 and 20 participants (27.13%) and the Grounded Theory framework (9.04%) stood out. The improved structuring of a qualitative research extends the effective communication between health providers and researchers, and support in the management of clinical situations.


Resumo A dificuldade de entendimento na literatura biomédica sobre a validade dos estudos qualitativos pode estar relacionada ao menor número de estudos qualitativos publicados. As críticas também vão desde a falta de profundidade teórica até discussões pouco objetivas de descobertas empíricas. O objetivo deste estudo foi explorar padrões bibliométricos e as tendências na estrutura das pesquisas qualitativas na literatura biomédica. Utilizou-se análise bibliométrica e mapeamento da literatura biomédica. O número de estudos selecionados foi 1.725. Os temas de saúde com mais publicações incluíram Gestão em Saúde (12%) e Saúde da Mulher (9,8%), enquanto os autores dos estudos tiveram afiliação acadêmica em 76 países diferentes. O tamanho da amostra mais observado foi de 11 a 20 participantes (27,13%) e o referencial da Grounded Theory (9,04%) o mais utilizado. A estruturação aprimorada de uma pesquisa qualitativa amplia a comunicação eficaz entre profissionais de saúde e pesquisadores, além de apoiar o gerenciamento de situações clínicas.


Subject(s)
Humans , Female , Bibliometrics , Biomedical Research , Research Personnel , Qualitative Research
7.
Ciênc. Saúde Colet ; 26(7): 2829-2832, jul. 2021.
Article in English, Portuguese | LILACS | ID: biblio-1278775

ABSTRACT

Resumo O texto explora o tema da suficiência brasileira em vacinas. Apresenta os caminhos praticados para a capacitação nas duas instituições brasileiras mais importantes no desenvolvimento e na produção de vacinas - o Instituto Butantan e o Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos). Esses caminhos referem-se à compra pura e simples, à compra do produto com compromisso de transferência de tecnologia, às parcerias que incluem a realização de ensaios da fase 1 pelo comprador, o novo caminho anunciado pelo Instituto Butantan no qual a parceria prevê a realização de ensaio nas fases 1 e 2 e, finalmente, a invenção, desenvolvimento e produção locais de vacinas. Este último caminho é apenas mencionado como possibilidade. Apresenta dados sobre as chances de sucesso no desenvolvimento de vacinas e louva a iniciativa do Butantan nessa nova modalidade de parceria.


Abstract The text explores the theme of Brazilian sufficiency in vaccines. It presents the ways practiced in the two most important Brazilian institutions in the development and production of vaccines - the Butantan Institute and the Institute of Technology in Immunobiologicals (Bio-Manguinhos). These paths are the pure and simple purchase, the purchase of the product with technology transfer commitment, partnerships that include the fulfillment of phase 3 trials by the buyer, the new path announced by Instituto Butantan in which the partnership includes for the realization of trials in phases 1 and 2 and, finally, the invention, development and local vaccine production. The latter is only mentioned as a possibility currently not achieved. Finally, the text presents data on the chances of success in vaccine development.


Subject(s)
Humans , Vaccines , Biomedical Research , Brazil , Academies and Institutes
9.
Int. j. med. surg. sci. (Print) ; 8(1): 1-13, mar. 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1151622

ABSTRACT

Este trabajo tiene como objetivodescribir el perfil de la producción científica referente a anquiloglosia. Para ello fuerealizada una investigación por medio de la búsqueda de artículos científicos indexados en las bases de datos electrónicas LILACS y PUBMED. Para la revisión bibliométrica fueron considerados y tabulados los datos referidos al año de publicación, tipo de estudio y nivel de evidencia. Los datos fueron discutidos sobre la óptica cuantitativa y de valores representativos. Los primeros resultados permitieron analizar 651 estudios publicados. La mayor parte de las investigaciones sobre anquiloglosia encontradas correspondieron a estudios de tipo descriptivo y serie de casos (49,31%) seguido de relato de caso, investigación in vitro, en animales y revisión de literatura (24,27%), cohorte y casos-controles (11,98%), opinión de experto (11,68%), ensayo clínico randomizado (1,54%) y revisión sistemática (1,22%). Pocos estudios abordaron complicaciones durante o después de la realización de la cirugía para liberación del frenillo lingual. En conclusión, la producción científica sobre anquiloglosia ha mostrado un creciente aumento en los últimos 28 años, siendo publicados estudios con nivel de evidencia 1, 2 y 3, cuyo mayor enfoque fue realizado en la cirugía para la liberación del frenillo lingual.


This work aims to describe the profileof scientific production referring to ankyloglossia. For this an investigation was carried out by searching for scientific articles indexed in the electronic databases LILACS and PUBMED. For the bibliometric review, the data referring to the year of publication, type of study and level of evidence were examined and tabulated. The data were discussed on the quantitative and representative values optics. The first results allowed to analyzic 651 published studies were analyzed. Most of the research on tongue tie found correspond to descriptive studies and case series (49.31%), followed by case reports, in vitro research, in animals and literature review (24.27%), cohort and cases and controls (11.98%), specialist opinion (11.68%), randomized clinical trials (1.54%) and systematic reviews (1.22%). Few studies addressed complications during or after lingual frenulum release surgery. In conclusion Scientific production on ankyloglossia has shown an increasing increase in the last 28 years, with studies with evidence levels 1, 2 and 3 being published, whose main focus was the performance of surgery to release the lingual frenulum.


Subject(s)
Bibliometrics , Biomedical Research/statistics & numerical data , Ankyloglossia , Epidemiology, Descriptive
10.
Article in Spanish | LILACS, CUMED | ID: biblio-1280209

ABSTRACT

La publicación científica en ciencias de la salud constituye una necesidad, pues pone a disposición de la comunidad académica nuevos conocimientos generados a partir de la investigación. Mostrar estos resultados es beneficioso para los sistemas de salud, ya que evita realizar investigaciones duplicadas, ahorra presupuesto a los organismos y favorece el desarrollo de la ciencia, sustentado en nuevos resultados. El proceso de publicación científica constituye un acuerdo bilateral entre el investigador y la revista, donde el autor confía sus resultados a esta, y la revista, a la vez, confía en la veracidad de los resultados y la moralidad del investigador(AU)


Subject(s)
Humans , Plagiarism , Scientific Misconduct , Biomedical Research , Health Sciences , Scientific and Technical Publications , Scientific Publication Ethics
11.
Rev. cub. inf. cienc. salud ; 32(1): e1457, tab, fig
Article in Spanish | LILACS, CUMED | ID: biblio-1280207

ABSTRACT

Próximo a la acreditación del proceso docente, y con la particularidad de contar con un claustro de profesores de diferentes instituciones, el Centro de Investigaciones y Referencias de Aterosclerosis de La Habana evaluó su producción científica. La presente investigación se propuso caracterizar la producción científica de los profesores de la Maestría en Investigación en Aterosclerosis de las tres últimas ediciones en el período 2014-2018. Para esto, se realizó un estudio bibliométrico, descriptivo y retrospectivo. Se empleó el Google Académico y la sección de libros de Infomed para acceder a las publicaciones de los profesores. Se evaluó la actividad de la producción científica, la colaboración lograda y el impacto alcanzado. Se encontraron 326 publicaciones. El año 2015 fue el más productivo y los artículos de revistas resultaron el tipo de documento más publicado. Un total de 13 docentes fueron los grandes productores. De los trabajos publicados, 2/3 se encontraron en 57 revistas diferentes. El 84 por ciento de los artículos fue escrito por más de un autor; en el 20 por ciento participaron alumnos y profesores; el 42 por ciento fue liderado por nuestro claustro y el 49 por ciento fue citado por parte del resto de la comunidad científica. Un único trabajo se valoró de excelencia. El índice de inmediatez fue de 0,2 y el índice h fue 16. Se conformaron 16 índices bibliográficos. La producción científica del claustro resulta ser amplia, algo dispersa, abarcadora de los temas de la Maestría, la cual está caracterizada por la disminución de las publicaciones, la no declaración de la institución y la falta de uniformidad de los nombres de los autores. El impacto está presente en pocas publicaciones. Se evidencia la capacidad del claustro para publicar, básicamente en revistas de alto impacto. Se revela la colaboración existente entre los autores(AU)


Soon to receive accreditation of its teaching process, and with the distinguishing feature of gathering professors from various institutions, the Center for Atherosclerosis Research and Reference in Havana has carried out an evaluation of its scientific production. The purpose of the evaluation was to characterize the scientific production of professors from the Atherosclerosis Research Master's Degree program in its last three editions (2014-2018). To achieve such an end, a retrospective descriptive bibliometric study was conducted. Use was made of Google Scholar and the Infomed book section to access the publications contributed by professors. The evaluation covered scientific production, collaboration obtained and impact achieved. A total 326 publications were found. The year 2015 was the most productive, and journal papers were the most commonly published document type. A total 13 teachers were the most prolific authors. Of the papers published, 2/3 were found in 57 different journals. 84 percent of the papers were written by more than one author, students and teachers participated in 20 percent, 42 percent were headed by members of our faculty, and 49 percent were cited by part of the rest of the scientific community. A single paper was ranked as excellent. Immediacy index was 0.2, whereas h index was 16. Sixteen bibliographic indices were formed. Scientific production by the faculty was found to be abundant, somewhat dispersed, covering the topics in the master's degree program, which is characterized by a reduction in the number of publications, the non-declaration of the institution and the non-uniformity in authors' names. Impact is present in few publications. Evidence was found of the faculty's capacity to publish, basically in high-impact journals. The collaboration existing between authors was also revealed(AU)


Subject(s)
Humans , Biomedical Research , Education, Medical, Graduate , Scientific and Technical Publications , Atherosclerosis , Faculty, Medical , Periodicals as Topic , Bibliometrics , Retrospective Studies , Cuba
12.
Hist. ciênc. saúde-Manguinhos ; 28(1): 283-292, mar. 2021. graf
Article in English | LILACS | ID: biblio-1154320

ABSTRACT

Abstract This work focuses on the scientific research conducted by women at Portugal's Institute of Tropical Medicine between 1943 and 1966. The Institute's scientific journal documents the participation of women in tropical medicine during this period. Their publications addressed a variety of subjects and resulted from research carried out in the metropolis as well as Portugal's overseas colonies. Most of the articles written by these women were are co-authored by their male colleagues, reflecting the incorporation of female researchers into scientific networks already established by men. This work in progress provides a starting point to lend visibility to a group of scientific actors who are practically absent from the historiography of tropical medicine.


Resumo O foco deste trabalho é a pesquisa científica realizada por mulheres no Instituto de Medicina Tropical, em Portugal, entre 1943 e 1966. O periódico científico do Instituto documenta a participação das mulheres na medicina tropical nesse período. Suas publicações abordavam uma diversidade de temas e resultaram de pesquisas realizadas na metrópole, bem como nas colônias ultramarinas de Portugal. A maioria dos artigos escritos por mulheres contava com a coautoria de seus colegas homens, refletindo a incorporação de pesquisadoras às redes científicas já estabelecidas por homens. Este trabalho em andamento representa um ponto de partida para dar visibilidade a um grupo de atores científicos que está praticamente ausente da historiografia da medicina tropical.


Subject(s)
Humans , Female , History, 20th Century , Tropical Medicine/history , Women/history , Biomedical Research/history , Academies and Institutes/history , Periodicals as Topic/history , Portugal , Science/history
15.
Article in Spanish | LILACS, BINACIS | ID: biblio-1247465

ABSTRACT

Para que una persona sea merecedora de la autoría de una investigación debe haber realizado alguna contribución académica sustancial para que esta pudiera llevarse a cabo y, además, ser capaz de dar cuenta públicamente de la integridad de sus procesos y sus resultados. Este artículo resume: 1) la matriz propuesta por L. W. Roberts para contribuir a definir las autorías durante las etapas iniciales de la investigación, 2) los criterios de autoría del Comité Internacional de Editores de Revistas Médicas para definir quiénes merecen dichos créditos y quiénes no, 3) la taxonomía de 14 roles propuesta por la Declaración CRediT para transparentar las tareas realizadas por cada una de las personas proclamadas autoras de una investigación biomédica y 4) las principales conductas que degradan la transparencia de las autorías


For a person to deserve an investigation authorship he/she must have made some substantial academic contribution so that that research could be carried out and, in addition, must be able to publicly account for the integrity of their processes and their results. This article summarizes: 1) the matrix proposed by Roberts to help defining authorship during the initial stages of the investigation; 2) authorship criteria of the International Committee of Medical Journal Editors to define who deserves such credits and who does not; 3) the 14-role taxonomy proposed by the CRediT Declaration to transparent the tasks performed by each of the proclaimed authors of a biomedical research; 4) the main behaviors that degrade the transparency of authorships


Subject(s)
Research , Authorship , Classification , Biomedical Research , Research Personnel
18.
Chinese Journal of Lung Cancer ; (12): 668-672, 2021.
Article in Chinese | WPRIM | ID: wpr-922239

ABSTRACT

Immune checkpoint inhibitors (ICIs) is a negative regulatory factor antibody, which activates T cells to play an anti-tumor effect in immunotherapy, and can also cause immune-related adverse responses, thereby inducing a series of immune related adverse events (irAEs). Among these irAEs, although the incidence of ICIs-related myocarditis is very low, the fatality rate is significantly higher than other adverse reactions, close to 50%. Clinicians should be vigilant when applying ICIs, but the pathogenesis of ICIs-related myocarditis is still unclear. This article combines the recent research results of ICIs to summarize the mechanism and clinical manifestations of ICIs-related myocarditis, so as to improve clinicians' understanding of the adverse reactions.
.


Subject(s)
Biomedical Research/trends , Cardiotoxicity/physiopathology , Humans , Immune Checkpoint Inhibitors/therapeutic use , Immunotherapy/adverse effects , Myocarditis/physiopathology , Neoplasms/drug therapy
19.
Chinese Acupuncture & Moxibustion ; (12): 1273-1275, 2021.
Article in Chinese | WPRIM | ID: wpr-921044

ABSTRACT

The elements of ethical review related to clinical research of acupuncture and moxibustion is discussed to provide ideas for various institutions to carry out relevant ethical review. It is believed that the ethical review of clinical research of acupuncture and moxibustion needs to focus on the specificity of acupuncture and moxibustion. Starting from the basic theory of traditional Chinese medicine, the theory of meridians and acupoints and the theory of syndrome differentiation along meridians, the key contents of ethical review such as intervention methods, grouping design and placebo control should be considered, so as to standardize the clinical research of acupuncture and moxibustion and protect the health and rights and interests of participants.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Biomedical Research , Ethical Review , Humans , Meridians , Moxibustion
20.
Article in Chinese | WPRIM | ID: wpr-879081

ABSTRACT

At present, the issues regarding multi-center clinical trials of new drugs of traditional Chinese medicine(TCM) remain: the lack of agreement on the content and scope of the ethical review among the ethics committee members of the center and the participating units results in repeated review, which leads to a time-consuming ethical review process. Moreover, the review capabilities of the ethics committees of various research centers are uneven, which is not necessarily beneficial to the protection of subjects' rights and safety. In view of the existing problems, to improve the efficiency of ethical review of multi-center clinical trials of new drugs of TCM and avoid repeated reviews, the TCM Clinical Evaluation Professional Committee of Chinese Pharmaceutical Association organized experts to formulate the "Consensus on collaborative ethical review of multi-center clinical trials of new drugs of TCM(version 1.0)"(hereinafter referred to as "Consensus"). The "Consensus" is formulated in accordance with the requirements of relevant documents such as but not limited to "the opinions on deepening the reform of the evaluation and approval system to encourage the innovation of pharmaceutical medical devices", "the regulations of ethical review of biomedical research involving human subjects". The "Consensus" covers the scope of application, formulation principles, conditions for the ethics committee of the center, sharing of ethical review resources, scope and procedure of collaborative review, rights and obligations, etc. The aims of the "Consensus" is to preliminarily explore and establish a scientific and operable ethical review procedure. Additionally, on the basis of fully protecting the rights and interests of the subjects, a collaborative ethical review agreement needs to be signed to clarify the ethical review responsibilities of all parties, to avoid repeated review, and to improve the efficiency and quality of ethical review in multi-center clinical trials of new drugs of TCM.


Subject(s)
Biomedical Research , Clinical Trials as Topic , Consensus , Drugs, Chinese Herbal , Ethical Review , Humans , Medicine, Chinese Traditional , Multicenter Studies as Topic , Pharmaceutical Preparations
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