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1.
Rev. bras. med. esporte ; 27(1): 94-97, Jan.-Mar. 2021. tab
Article in English | LILACS | ID: biblio-1156103

ABSTRACT

ABSTRACT Introduction It is known that strength training brings improvements in health and sports performance by causing muscle hypertrophy and increased strength, as well as modifying some hemodynamic and physiological factors. Several strength training methodologies have been developed, one of which is vascular occlusion. There are few studies with large muscle groups due to poor adherence to the training style and the fact that vascular occlusion of large muscle groups is more difficult. Objective To verify and compare the hemodynamic effects of exercise with and without vascular occlusion in different muscle groups. Methods Quantitative crossover study, with cross-sectional and field procedures. The sample consisted of 10 physically active healthy male and female subjects between 18 and 30 years of age. With the cross-over design, all the volunteers participated in 3 groups: intervention with vascular occlusion, intervention without vascular occlusion and the control group. Results Overall, lactate and cholesterol remained elevated after 15 minutes of recovery and blood glucose and blood pressure did not vary among the groups. Conclusion Vascular occlusion training is an effective method for manipulating hemodynamic variables. Evidence level II; Clinical study.


RESUMO Introdução Sabe-se que o treino de força traz melhorias para a saúde e o desempenho esportivo, por ocasionar hipertrofia muscular e aumento de força, além de modificar alguns fatores hemodinâmicos e fisiológicos. Foram desenvolvidos vários métodos de treinamento de força, entre eles, a oclusão vascular. Porém, existem poucos estudos com grandes grupamentos musculares, devido à pouca adesão ao estilo de treino e ao fato de a oclusão vascular de grandes grupos musculares ser mais difícil. Objetivo Verificar e comparar os efeitos hemodinâmicos do exercício com e sem oclusão vascular em diferentes grupamentos musculares. Métodos Estudo quantitativo, cruzado, com procedimentos transversais e de campo. A amostra foi composta por 10 indivíduos saudáveis e fisicamente ativos do sexo masculino e feminino, na faixa etária de 18 a 30 anos. Com o desenho cruzado, todos os voluntários participaram de 3 grupos: intervenção com oclusão vascular, intervenção sem oclusão vascular e grupo controle. Resultados De forma geral, entre grupos, o lactato e o colesterol se mantiveram elevados depois de 15 minutos de recuperação, a glicemia e as pressões arteriais não variaram. Conclusão O treinamento com oclusão vascular é um método eficaz para manipular as variáveis hemodinâmicas. Nível de evidência II; Estudo clínico.


RESUMEN Introducción Se sabe que el entrenamiento de fuerza trae mejoras para la salud y el desempeño deportivo, por causar hipertrofia muscular y aumento de fuerza, además de modificar algunos factores hemodinámicos y fisiológicos. Fueron desarrollados varios métodos de entrenamiento de fuerza, entre ellos, la oclusión vascular. Sin embargo, existen pocos estudios con grandes grupos musculares, debido a la poca adhesión al estilo de entrenamiento y al hecho de que la oclusión vascular de grandes grupos musculares grandes es más difícil. Objetivo Verificar y comparar los efectos hemodinámicos del ejercicio con y sin oclusión vascular en diferentes grupos musculares. Métodos Estudio cuantitativo, cruzado, con procedimientos transversales y de campo. La muestra fue compuesta por 10 individuos saludables y físicamente activos del sexo masculino y femenino, en el grupo de edad de 18 a 30 años. Con el diseño cruzado, todos los voluntarios participaron en 3 grupos: intervención con oclusión vascular, intervención sin oclusión vascular y grupo control. Resultados De forma general, entre los grupos, el lactato y el colesterol se mantuvieron elevados después de 15 minutos de recuperación, la glucemia y las presiones arteriales no variaron. Conclusión El entrenamiento de oclusión vascular es un método eficaz para manipular las variables hemodinámicas. Nivel de evidencia II; Estudio clínico.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Physical Endurance/physiology , Blood Circulation , Exercise/physiology , Muscles/blood supply , Blood Glucose/analysis , Restraint, Physical , Cholesterol/blood , Cross-Sectional Studies , Lactic Acid/blood , Hemodynamics
2.
Ciênc. cuid. saúde ; 20: e56251, 2021. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1356107

ABSTRACT

RESUMO Objetivo: analisar as práticas assistenciais no uso do cateter venoso central para a prevenção das Infecções Primárias da Corrente Sanguínea em uma Unidade de Terapia Intensiva. Método: estudo transversal realizado em um Hospital Universitário entre março e junho de 2018 com profissionais de uma Unidade de Terapia Intensiva. Utilizaram-se questionário estruturado e observação não participante dos procedimentos inserção, preparo e administração de medicação e troca de curativos de cateter central. Os dados foram analisados por meio da estatística descritiva com aplicação do Teste Qui-quadrado e exato de Fisher. Resultados: participaram 83 profissionais de enfermagem e 25 médicos. Foram observadas 260 administrações de medicações, 32 inserções de cateter e 29 trocas de curativos. Houve inadequação da prática de higienização das mãos nos procedimentos de manutenção, principalmente entre os técnicos de enfermagem. Os melhores resultados foram preparo da pele (94%), secagem espontânea do antisséptico antes das punções (96,87%) e respeito às trocas dos equipos de infusão contínua e intermitente (93,42%). Conclusão: o seguimento dasmedidas preventivas estava comprometido em oportunidades importantes para evitar Infecções Primárias da Corrente Sanguínea, sendo necessário reforçar a educação permanente e a implementação de protocolos assistenciais.


RESUMEN Objetivo: analizar las prácticas asistenciales en el uso del catéter venoso central para la prevención de las Infecciones Primarias de la Circulación Sanguínea en una Unidad de Cuidados Intensivos. Método: estudio transversal realizado en un Hospital Universitario entre marzo y junio de 2018 con profesionales de una Unidad de Cuidados Intensivos. Se utilizaron cuestionario estructurado y observación no participante de los procedimientos inserción, preparación y administración de medicación y cambio de vendajes de catéter central. Los datos fueron analizados por medio de la estadística descriptiva con aplicación delaPrueba Chi-cuadrado y exacta de Fisher. Resultados: participaron 83 profesionales de enfermería y 25 médicos. Se observaron 260 administraciones de medicamentos, 32 inserciones de catéter y 29 intercambios de vendajes. Hubo inadecuación de la práctica de higienización de las manos en los procedimientos de mantenimiento, principalmente entre los técnicos de enfermería. Los mejores resultados fueron preparación de la piel (94%), secado espontáneo del antiséptico antes de las punciones (96,87%) y respeto a los cambios de los equipos de infusión continua e intermitente (93,42%). Conclusión: el seguimiento de las medidas preventivas estaba comprometido en oportunidades importantes para evitar Infecciones Primarias de la Circulación Sanguínea, siendo necesario reforzar la educación permanente y la implementación de protocolos asistenciales.


ABSTRACT Objective: to analyze healthcare practices in the use of central venous catheters for the prevention of Primary Bloodstream Infections in an Intensive Care Unit. Method: cross-sectional study conducted in a University Hospital between March and June 2018 with professionals working in an Intensive Care Unit. A structured questionnaire and non-participant observation of the procedures related to insertion, preparation and administration of drugs and change of central catheter dressings were used. The data were analyzed using descriptive statistics and applying the Chi-square and Fisher's exact tests. Results: a total of 83 nursing professionals and 25 physicians participated. There were 260 drug administrations, 32 catheter insertions and 29 dressing changes. There was inadequacy of the hand hygiene practice in maintenance procedures, especially among nursing technicians. The best results were: skin preparation (94%), spontaneous drying of the antiseptic before punctures (96.87%) and respect for the changes of continuous and intermittent infusion sets (93.42%). Conclusion: the follow-up of preventive measures was undermined in important opportunities to avoid Primary Bloodstream Infections, being necessary to reinforce continuing education and implementation of healthcare protocols.


Subject(s)
Humans , Male , Female , Blood Circulation , Infections , Physicians , Professional Practice , Bandages , Pharmaceutical Preparations , Cross Infection , Sepsis , Education, Continuing , Disease Prevention , Catheters , Patient Safety , Central Venous Catheters , Hand Hygiene , Licensed Practical Nurses , Hand , Intensive Care Units , Nurse Practitioners , Nurses, Male
3.
Rev. enferm. UERJ ; 28: e53033, jan.-dez. 2020.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1146255

ABSTRACT

Objetivo: desenvolver e validar um protótipo de baixo custo para reanimação cardiopulmonar em adultos, com ênfase nos fluxos arteriais e venosos para fins educacionais. Método: trata-se de estudo oriundo de trabalho de conclusão de curso, utilizando abordagem do design thinking para elaboração do protótipo, realizado em uma universidade pública federal no sul do Brasil, entre setembro e novembro de 2019. Na validação, participaram 13 indivíduos com expertise em Urgência e Emergência, sendo utilizado um instrumento com escala Likert, composto por sete itens sobre aparência e usabilidade. Resultados: o protótipo foi idealizado usando um manequim de exposição de roupas como estrutura principal. Além do tórax permitir compressões, uma rede de ductos que simulam os fluxos sanguíneos demonstrou visualmente a circulação sanguínea e a injeção de medicações intravenosas. Conclusão: o protótipo possui capacidade de potencializar o processo de ensinoaprendizagem em suporte básico e avançado de vida, especialmente quando sustentado por metodologias ativas.


Objective: to develop and validate a low-cost prototype for cardiopulmonary resuscitation in adults, with an emphasis on arterial and venous flows, for educational purposes. Method: this study, which originated from a course conclusion project to develop a prototype using the design-thinking approach, was conducted at a federal public university in southern Brazil between September and November 2019. Thirteen individuals with expertise in emergency care took part in validation, using a Likert scale instrument consisting of seven items on appearance and usability. Results: the prototype was designed using a clothing display mannequin as the main structure. Compressions could be performed on the chest, and a network of ducts simulated blood flows visually, demonstrating blood circulation and intravenous medication injections. Conclusion: the prototype was able to enhance teaching and learning on basic and advanced life support, especially when supported by active methodologies.


Objetivo: desarrollar y validar un prototipo de bajo costo para reanimación cardiopulmonar en adultos, con énfasis en los flujos arteriales y venosos, con fines educativos. Método: este estudio, que se originó a partir de un proyecto de conclusión de curso para desarrollar un prototipo utilizando el enfoque de pensamiento de diseño, se realizó en una universidad pública federal en el sur de Brasil entre septiembre y noviembre de 2019. En la validación participaron trece personas con experiencia en atención de emergencias , utilizando un instrumento de escala Likert que consta de siete ítems sobre apariencia y usabilidad. Resultados: el prototipo se diseñó utilizando un maniquí de exhibición de ropa como estructura principal. Se podían realizar compresiones en el pecho y una red de conductos simulaba visualmente los flujos sanguíneos, lo que demostraba la circulación sanguínea y las inyecciones de medicación intravenosa. Conclusión: el prototipo fue capaz de mejorar la enseñanza y el aprendizaje sobre soporte vital básico y avanzado, especialmente cuando fue apoyado por metodologías activas.


Subject(s)
Universities , Cardiopulmonary Resuscitation/education , Simulation Training , Proof of Concept Study , Blood Circulation , Brazil , Simulation Technique , Low Cost Technology , Applied Research , Learning , Manikins , Models, Anatomic
4.
Rev. bras. ciênc. mov ; 28(2): 157-162, abr.-jun. 2020. tab
Article in Portuguese | LILACS | ID: biblio-1128104

ABSTRACT

Objetivos: comparar os efeitos do treino com restrição de flux o sanguíneo com o treino resistido de alta intensidade no ganho de força e hipertrofia. Material e métodos: n este ensaio clínico randomizado e controlado, 24 homens sedentários foram randomizados em do is grupo s: treino com restrição de fluxo sanguíneo ou treino resistido de alta intensidade. Ambos os grupos realizaram 10 sessões de exercício de preensão manual até com 3 séries de exercícios até a falha, sendo que o grupo com treino de restrição de fluxo sanguíneo realizou com 30% da carga máxima obtida no teste de 1 repetição máxima, enquanto que o grupo de alta intensidade realizou com 80% da carga. T odo s o s voluntários foram avaliados e reavaliados a dinamometriade preensão manual e a perimetria de antebraço. Os dados foram tabulados e analisados no statistical package for the social sciences, utilizando o teste t-student, e o não paramétrico u de mann whitney, adotando a significância de 5% (α = 0,05). Resultados: para o desfecho força, identificou-se que tanto o grupo que treino com restrição do fluxo, quanto o grupo que treinou com alta intensidade tiveram aumentos significativos (p= 0,005 e 0,026, respectivamente). Já em relação ao aumento da circunferência, notou-se que somente o treino de restrição do flux o se mostrou estatisticamente quando comparado o aumento entre os grupos (p= 0,00 1). Conclusão: foi possível concluir que o treinamento com restrição do fluxo sanguíneo mostrou eficaz tanto para o ganho de força, quanto para o aumento de circunferência, apresentando vantagens quando comparado ao grupo de treinamento resistido com alta intensidade...(AU)


Objectives: to compare the effects of blood flow restriction trainin g wit h h igh in tensity resistance training on strength gain and hypertrophy. Material and methods: in this randomized controlled trial, 24 sedentary men were randomized into two groups: restricted blood flow training or high inten sity resistance training. Both groups performed 10 handgrip exercise sessions up to 3 sets of exercises un t il failure, and the group with blood flow restriction training performed with 3 0 % o f t he m ax imum lo ad obtained in the 1-repetition maximum test, while the high intensity group performed with 80% of the load. All volunteers were assessed and reassessed by handgrip dynamometry and forearm perimetry. Data were tabulated and analyzed in the statistical package for the social sciences, using the t-studen t test an d t he non-parametric mann whitney u test, adopting the significance of 5% (α = 0.05). Results: for the stren gth outcome, it was found that both the flow restriction training group and the high intensity train in g gro up had significant increases (p = 0.005 and 0.026, respectively). Regarding the increase in circumference, it was noted that only the flow restriction training was statistically when compared to the increase bet ween the groups (p = 0.001). Conclusion: it was concluded that training with blood flow restriction was effective for both strength gain and circumference increase, presenting advantages when compared to the high intensity resistance training group...(AU)


Subject(s)
Humans , Male , Blood Circulation , Exercise , Muscle Strength , Resistance Training , Sedentary Behavior , High-Intensity Interval Training , Hypertrophy , Men , Physical Education and Training , Blood , Forearm
5.
J. Phys. Educ. (Maringá) ; 31: e3101, 2020. tab, graf
Article in English | LILACS | ID: biblio-1098329

ABSTRACT

ABSTRACT The ice application (cooling) has become popular during physical activities to improve performance. This study aimed to test whether different cooling places could increase the number of repetitions (volume) during resistance training with blood flow restriction (BFR). Ten women volunteered for this study. The sample characterization is presented in mean and standard deviation: age: 28.5 ± 8.6 years; height: 164.6 ± 8.3 cm; total body mass: 61.5 ± 7.1 maximal dynamic strength test (1RM): 236.5 ± 54.8 kg; 30% 1RM: 71.6 ± 16.5; SBP: 124.7 ± 7.7 mm Hg; 1.3 x SBP: 161.8 ± 10.4 mm Hg. The subjects performed five sessions of resistance exercise with BFR. Three sets were held in each session, with the intensity of 30% of 1RM until muscle failure; and 30-second rest period between sets. The cooling sites were: hands, neck, and tunnel temperature. One session without cooling was done and considered as a control group. There was neither difference in the total number of repetitions of repetitions among interventions, nor a significant difference among interventions for RPE (P = 0.49). Therefore, we do not recommend cooling to maintain a high number of repetitions during strength training with BFR.


RESUMO A aplicação do gelo (resfriamento) tem sido uma estratégia popular durante as atividades físicas para aumentar o desempenho. O objetivo deste estudo foi testar se diferentes locais de resfriamento podem aumentar o número de repetições (volume) durante o treinamento resistido com restrição do fluxo sanguíneo (RFS). Dez mulheres se voluntariaram para este estudo. A caracterização da amostra é apresentada em média e desvio padrão: idade: 28,5 ± 8,6 anos; estatura: 164,6 ± 8,3 cm; massa corporal total: 61,5 ± 7,1; teste de força muscular dinâmica (1RM): 236,5 ± 54,8kg; 30% 1RM: 71,6 ± 16,5; PAS: 124,7 ± 7,7 mm Hg; 1,3 x PAS: 161,8 ± 10,4 mmHg, participaram do estudo. Os sujeitos realizaram cinco sessões de exercício resistido com RFS. Três séries foram realizadas em cada sessão, com a intensidade de 30% de 1RM até falha muscular e 30 segundos de descanso entre as séries. Os locais de resfriamento foram: mãos, pescoço e temperatura do túnel. Uma sessão sem resfriamento foi realizada e considerada como grupo controle. Não houve diferença no número total de repetições entre as intervenções, nem diferença entre as intervenções para percepção subjetiva de esforço (P = 0,49). Portanto, nós não recomendamos o resfriamento para manter um alto número de repetições durante o treinamento de força com restrição do fluxo sanguíneo.


Subject(s)
Humans , Female , Adult , Time , Blood Circulation , Cooling/methods , Resistance Training , Body Weight , Exercise , Athletic Performance , Arterial Pressure , Ice
6.
Experimental Neurobiology ; : 554-567, 2019.
Article in English | WPRIM | ID: wpr-763790

ABSTRACT

Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of the aging population after Alzheimer’s disease (AD). Defects in the lysosomal systems and mitochondria have been suspected to cause the pathogenesis of PD. Nevertheless, the pathogenesis of PD remains obscure. Abnormal cholesterol metabolism is linked to numerous disorders, including atherosclerosis. The brain contains the highest level of cholesterol in the body and abnormal cholesterol metabolism links also many neurodegenerative disorders such as AD, PD, Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). The blood brain barrier effectively prevents uptake of lipoprotein-bound cholesterol from blood circulation. Accordingly, cholesterol level in the brain is independent from that in peripheral tissues. Because cholesterol metabolism in both peripheral tissue and the brain are quite different, cholesterol metabolism associated with neurodegeneration should be examined separately from that in peripheral tissues. Here, we review and compare cholesterol metabolism in the brain and peripheral tissues. Furthermore, the relationship between alterations in cholesterol metabolism and PD pathogenesis is reviewed.


Subject(s)
Aging , Amyotrophic Lateral Sclerosis , Atherosclerosis , Blood Circulation , Blood-Brain Barrier , Brain , Cholesterol , Metabolism , Mitochondria , Neurodegenerative Diseases , Parkinson Disease
7.
Article in Chinese | WPRIM | ID: wpr-773711

ABSTRACT

Rat model of blood stasis syndrome was prepared by subcutaneous injecting of epinephrine hydrochlorid,then the model rats were administrated by Yunnan Baiyao for 15 days. Blood rheology,coagulation function and histopathology were chosen as indicators to evaluate the successful replication of blood stasis syndrome model and the treatment effect of Yunnan Baiyao. UPLC-Q-TOF-MS was used to rapidly analyze the serum samples of blood stasis syndrome rat after 15 days Yunnan Baiyao treatment,Progenesis QI software was employed to identify the alkaloids components. The results showed that Yunnan Baiyao reduced the plasma viscosity and whole blood viscosity of rats with blood stasis syndrome,prolonged thrombin and prothrombin time,reduced fibrinogen content,and effectively improved pathological state such as inflammatory cell infiltration,blood stasis,congestion and edema of various organs in rats with blood stasis syndrome. Seven alkaloids components from Aconitum kusnezoffii,including karacolidine,senbusine B,isotalatizidine,karakoline,denudatine,talatisamine and chasmanine were found in the rat serum after Yunnan Baiyao treatment. Based on the effectiveness of Yunnan Baiyao in the treatment of blood stasis syndrome induced by epinephrine hydrochloride in rats,alkaloids components from the root of A. kusnezoffii absorbed into blood after Yunnan Baiyao treatment were clarified rapidly and accurately with the help of UPLC-Q-TOF-MS. Karacolidine,senbusine B,isotalatizidine,karakoline,denudatine,talatisamine and chasmanine are the pharmacodynamic material basis of the root of A. kusnezoffii for activating blood circulation and removing blood stasis.


Subject(s)
Aconitum , Chemistry , Animals , Blood Circulation , Blood Viscosity , Drugs, Chinese Herbal , Pharmacology , Prothrombin Time , Rats , Thrombin Time
8.
Article in Chinese | WPRIM | ID: wpr-771505

ABSTRACT

This study aims to observe the intervention effects of Chinese herbal medicine of supplementing Qi and activating blood circulation on chronic intermittent hypoxia(CIH) composite insulin resistance(IR) mediated atherosclerosis(AS) mice model,and to observe the mechanism of SREBP-1 c signaling molecule.IR Apo E-/-mice model was induced by high-fat diet combined with STZ injection.Then the mice were treated with hypoxic animal incubator for 8 h per day and 8 weeks to establish a CIH+IR-ApoE-/-mouse model.Model mice were randomly and averagely divided into normoxic control group(NC),model group(CIH) and SREBPs inhibitor group(betulin),atorvastatin group(WM),TCM low-dose group(TCM-L),TCM middle-dose group(TCM-M) and TCM high-dose group(TCM-H) group.Chinese herbal medicine of supplementing Qi and activating blood circulation including ginsenosides combined with ligustrazine(TMP) were used as intervention drugs.The study observed the effect of drugs on IR,serum lipid,inflammation,stress,AS and SREBP-1 c related molecules.The results showed that fasting blood glucose in TCM-H group decreased compared with other experimental groups(P<0.05).HDL-C level in betulin group,WM group,TCM-H group was higher than that in CIH group(P<0.05).LDL-C level in TCM-M group,TCM-H group is lower than that in CIH group(P<0.05).The level of CRP in CIH group was higher than that in other groups(P<0.05).The level of SOD in TCM-H group was higher than that in CIH group(P<0.05).NC group and CIH group showed obvious AS aortic plaque,while betulin group,WM group,TCM-H group showed reduction in AS plaque(P<0.05).For descending aorta,AS plaque in CIH group was multiple and large,while less and smaller in WM group and TCM-H(P<0.05).The expression of SREBP-1 c and FAS in aorta and skeletal muscle in TCM-H group was lower than that in CIH group(P<0.05).In aorta,the expression of TNF-α and CD106(VCAM-1) was lower in TCM-H group than that in CIH group(P<0.05).In aorta,skeletal muscle and liver,the level of p-IRS-1 in TCM-H group was significantly higher than that in CIH group(P<0.05).In aorta and liver,the expression of HIF-1α in TCM-H group was lower than that in CIH group(P<0.05).The study demonstrated that combination ginsenosides with TMP could improve IR and serum lipid level and inhibit inflammation and oxidative stress as well as ultimately alleviate AS to some extent.And the mechanism of its interventional effects might be related to the inhibition of CIH-induced upregulation of SREBP-1 c related molecules.


Subject(s)
Animals , Atherosclerosis , Drug Therapy , Blood Circulation , Drugs, Chinese Herbal , Pharmacology , Ginsenosides , Pharmacology , Hypoxia , Pathology , Insulin Resistance , Mice , Mice, Knockout, ApoE , Pyrazines , Pharmacology , Qi , Random Allocation
9.
Natural Product Sciences ; : 200-207, 2019.
Article in English | WPRIM | ID: wpr-760572

ABSTRACT

Albizzia julibrissin (AJ) is an herbal medicine that shows low toxicity, promotes promoting blood circulation and mitigates the inflammation and has mild side effects. Benign prostate hyperplasia (BPH) is one of the most common diseases that occurs in older males and often results in lower urinary tract symptoms. This study was conducted to evaluate the protective effect of AJ against BPH using LNCaP cells and Sprague Dawley rats treated with testosterone. Treatment with AJ extract reduced the expression of androgen receptor (AR) and prostate-specific antigen (PSA) in vitro. In vivo, rats were divided into 6 groups: 1 (Normal Control); 2 (Testosterone propionate (TP) alone); 3 (TP + finasteride); 4 (TP + AJ 10 mg/kg); 5 (TP + AJ 50 mg/kg); 6 (TP + AJ 300 mg/kg). The groups treated with AJ showed reduced the relative prostate weights and BPH-related proteins were altered, with decreased AR, PSA and proliferating cell nuclear antigen (PCNA) observed by western blot. Histopathological analysis revealed the therapeutic effect of AJ, with a decreased thickness of epithelial cells and reduced level of PCNA and 5α-reductase type 2. These results suggest that AJ extract could ameliorate testosterone-induced benign prostatic hyperplasia.


Subject(s)
Albizzia , Animals , Blood Circulation , Blotting, Western , Diethylpropion , Epithelial Cells , Herbal Medicine , Humans , Hyperplasia , In Vitro Techniques , Inflammation , Lower Urinary Tract Symptoms , Male , Proliferating Cell Nuclear Antigen , Prostate , Prostate-Specific Antigen , Prostatic Hyperplasia , Rats , Rats, Sprague-Dawley , Receptors, Androgen , Testosterone , Weights and Measures
10.
Article in Chinese | WPRIM | ID: wpr-777453

ABSTRACT

The efficacy of traditional Chinese medicine is the therapeutic effect of the drug on the body. The nature of traditional Chinese medicine is a further generalization of the effect of efficacy,and there is an intrinsic relationship between efficacy and nature of traditional Chinese medicine. In this study,the nature-effect relationship is found on the whole level,through the research mode of " nature combination-targets of traditional Chinese medicine-modules of protein interaction network-efficiency". The results showed that the warm-pungent-liver protein interaction network mainly participated in lipid catabolic process,blood coagulation,platelet activation,heme oxidation,platelet degranulation,apoptotic process,acute inflammatory response to exert the effect of anti-tumor,antithrombotic,anti-myocardial ischemia and anti-inflammatory.


Subject(s)
Blood Circulation , Blood Coagulation , Humans , Inflammation , Lipid Metabolism , Liver , Medicine, Chinese Traditional
11.
Article in Chinese | WPRIM | ID: wpr-777452

ABSTRACT

Traditional Chinese medicine for promoting blood circulation and removing blood stasis is a kind of drug with cold or warm medicinal properties which is commonly used in clinical practice. It is an excellent carrier for studying the nature-effect relationship of traditional Chinese medicine. Therefore,this study will acquire the main active components and targets based on the drug-based research method. The Cytoscape 3. 5. 1 platform was used to construct the protein interaction network,and the Bin GO plug-in was used to perform functional annotation and statistical analysis on the identified functional modules. The results showed that the bitter-liver protein interaction network mainly participates in cell cycle process,lipid catabolic process,blood circulation to exert the effect of promoting blood circulation and removing blood stasis; the cold protein interaction network mainly participates in vasoconstriction through targets such as EDNRA,regulates blood coagulation through targets such as PLAU,and thus exerts the effect of cooling blood and eliminating phlegm; warm protein interaction network mainly participates in the regulation of platelet activation through targets such as P2 RY12,thereby exerting the effect of promoting blood circulation,relieving pain and relieving pain. This study explains the common characteristics of the bitter-liver combination and the specific characteristics of cold or warm medicinal properties from the molecular network level,which provides a new idea for the intrinsic relationship between the medicinal properties and efficacy of traditional Chinese medicine.


Subject(s)
Blood Circulation , Blood Coagulation , Humans , Liver , Medicine, Chinese Traditional , Research
12.
Article in Chinese | WPRIM | ID: wpr-777451

ABSTRACT

The herbs for promoting blood circulation and removing blood stasis were used commonly in clinical,and most of them are pungent and bitter. In order to study the nature-effect interrelationship of the herbs for promoting blood circulation and removing blood stasis,the TCMSP platform and Cytoscape 3. 5. 1 platform were used to construct warm-pungent-liver and warm-bitter-liver of the complement and intersection protein interaction network and the target-disease network and the network module was analyzed. As a result,warm-liver target-disease network is associated with diseases such as cancer,hypertension,and depression,which exerts the efficacy of warming Yang and transforming Qi,promoting Qi and activating blood,removing blood stasis and dispersing phlegm. The bitter taste target-disease network is associated with diseases such as myocardial infarction,cancer,inflammation and other diseases,which exerts the efficacy of dissipating the stasis. The pungent taste target-disease network is associated with diseases such as cancer,cardiovascular disease,osteoporosis and other diseases,which exerts the efficacy of invigorating the circulation of blood and eliminating stagnation. The research shows that the medicinal combination of warm-pungent-liver and warm-bitter-liver has the efficacy of promoting blood circulation and removing blood stasis by regulating different targets in different disease processes.


Subject(s)
Blood Circulation , Humans , Liver , Medicine, Chinese Traditional , Qi , Research , Taste
13.
Article in English | WPRIM | ID: wpr-739996

ABSTRACT

OBJECTIVE: Arthrocentesis is a minimally invasive surgical procedure that is used to alleviate the symptoms of temporomandibular joint (TMJ) disorders. The aim of this study was to investigate the effect of arthrocentesis on the blood supply to the retinal structures. MATERIALS AND METHODS: Arthrocentesis was performed on 20 patients with TMJ disorders, and choroidal thickness (CT) in patients was measured to evaluate retinal blood circulation. The blood volume of the retinal structures was evaluated ipsilaterally before and after arthrocentesis, and these measurements were then compared with measurements obtained from the contralateral side. RESULTS: Before arthrocentesis, there were no differences in retinal blood volumes between the ipsilateral and contralateral sides (P = 0.96). When ipsilateral CT measurements taken before and after arthrocentesis were compared, retinal blood supply was found to have significantly decreased after arthrocentesis (P = 0.04). When contralateral CT measurements taken before and after arthrocentesis were compared, retinal blood supply was also found to have decreased after arthrocentesis, but not significantly (P = 0.19). CONCLUSION: The solution of local anesthesia with epinephrine applied before the arthrocentesis procedure was found to reduce the blood volume of the retinal structures. To the best of our knowledge, this is the first study that has investigated the blood volume of the retinal structures following arthrocentesis.


Subject(s)
Anesthesia , Anesthesia, Local , Arthrocentesis , Blood Circulation , Blood Volume , Choroid , Epinephrine , Humans , Retinaldehyde , Temporomandibular Joint Disorders , Temporomandibular Joint
14.
Bol. méd. postgrado ; 34(2): 39-45, Jul-Dic. 2018. ilus, tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1120815

ABSTRACT

En el servicio de emergencia pediátrica es fundamental reconocer de forma precoz los signos clínicos que indican amenaza para la vida del paciente. Con el objetivo de establecer la utilidad del Triángulo de Evaluación Pediátrica (TEP) en pacientes que asistieron al Servicio de Emergencia Pediátrica del Servicio Desconcentrado Hospital Pediátrico Dr. Agustín Zubillaga durante el lapso marzo-abril 2018, se realizó un estudio descriptivo, transversal, con una muestra de 216 pacientes, reportando un promedio de edad de 2,98 ± 3,06 años, de los cuales 36,11% eran lactantes menores de un año y 22,69% lactantes mayores, con ligero predominio del sexo masculino (53,7%). Al desglosar cada componente del TEP, se encontraron alterados la apariencia, lenguaje (61,54%), estado de conciencia (53,85%) y tono (50%); en la respiración predominó el tiraje subcostal (86,21%), tiraje intercostal (34,48%), quejido espiratorio (24,14%) y dificultad para hablar (17,24%). Para la circulación se registró palidez en membranas mucosas (91,89%) y piel (54,05%). El 68,98% de los pacientes tenían una situación estable, 9,26% dificultad respiratoria y 9,72% shock compensado. El 86,11% de los pacientes se manejaron de forma ambulatoria. Este estudio aporta información relevante sobre el TEP como herramienta útil para identificar y clasificar la gravedad de una emergencia pediátrica en nuestro hospital(AU)


In the pediatric emergency room it is essential to recognize the clinical signs that indicate the threat of the patient's condition on time. In order to establish the usefulness of the Pediatric Assessment Triangle (PET) in pediatric patients who attended the Emergency Service of the Servicio Desconcentrado Hospital Pediátrico Dr. Agustin Zubillaga during the period March-April 2018, a cross-sectional descriptive study was conducted with a total of 216 patients, with an average age of 2,98 ± 3,06 years, of which 36,11% were under one year old and 22,69% infants were one to two years old, with a slight predominance of males (53,70%). According to each component of the PET, 61,54% of patients had alterations in their appearance and general state, language (61,54%), state of consciousness (53,85%) and tone (50%). With respect to the work of breathing, subcostal retractions prevailed (86,21) as well as intercostal retractions (34,48%), expiratory moans (24,14%) and difficulty in speaking (17,24%). For the circulation part of the PET, pallor was register in mucous membranes (91,86%) and skin (54,05%). The physiopathological diagnoses were stability in 68,98% of cases, 9,26% had respiratory difficulty and 9,72% had compensated shock. The decision of admission was made in 13,89% of cases while 86,11% of cases were managed in an ambulatory manner. This study provides relevant information of the Pediatric Assessment Triangle as a useful tool to identify and classify the severity of a pediatric emergency in our hospital(AU)


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Signs and Symptoms , Child Health , Medical Care , Respiration , Blood Circulation , Pediatric Emergency Medicine
15.
Braz. J. Vet. Res. Anim. Sci. (Online) ; 55(4): [e149316], Dezembro 21, 2018. ilus, tab
Article in English | LILACS, VETINDEX | ID: biblio-998590

ABSTRACT

The heart of a domestic swine is similar to that of a human regarding anatomy, blood perfusion, and distribution of nurturing arteries. In addition to the similarities, its low cost compared with other species is also one of the reasons these animals have been increasingly used in medical schools and in clinical, surgical, and pharmacological studies. Therefore, we aimed to identify the origin and distribution of the right and left coronary arteries of boars, emphasizing the configuration and macroscopic representativity of their branches while characterizing a possible dominance concerning the type of circulation and the potential use of this animal as an experimental model, hence boars are the ancestors of the domestic pigs. The left coronary artery has bifurcated into paraconal interventricular branch and circumflex branch; or it has trifurcated into paraconal interventricular branch, the oblique branch, and into the left circumflex branch. The right coronary artery has originated the marginal branches to the right ventricle and the right circumflex branch, which has branched out in the subsinuous interventricular branch. Anastomoses have stood out among the paraconal and subsinuous interventricular branches ­ where a right dominant coronary artery occurred ­ and between the right and left circumflex branches. We concluded that the morphology and the distribution of the coronary arteries of boars resemble those of a human and, thus, our results are useful for the conception of experimental hemodynamics and possible use as process models.(AU)


O coração dos suínos domésticos apresenta semelhanças ao dos humanos mediante a anatomia, perfusão sanguínea e configuração da distribuição de suas artérias nutridoras. Tendo um menor custo para sua aquisição quando comparado a outras espécies, e dada sua similaridade apresentada, o uso desses animais nas escolas de medicina, em estudos clínicos, cirúrgicos e farmacológicos tem aumentado. Portanto, objetivou-se identificar a origem e distribuição das artérias coronárias direita e esquerda de javalis com ênfase na configuração e representatividade macroscópica dos ramos derivados das mesmas, caracterizando uma possível dominância quanto ao tipo de circulação e o potencial uso deste suídeo como modelo experimental, visto que são considerados ancestrais dos suínos domésticos. A artéria coronária esquerda bifurcou-se e deu origem aos ramos interventricular paraconal e circunflexo esquerdo, ou trifurcou-se nos ramos interventricular paraconal, oblíquo e circunflexo esquerdo. Já a artéria coronária direita deu origem aos ramos marginal para o ventrículo direito e circunflexo direito que, por sua vez, ramificou-se no ramo interventricular subsinuoso. Foram evidenciadas anastomoses entre os ramos interventriculares paraconal e subsinuoso, e entre os ramos circunflexos direito e esquerdo e, conforme tal origem do ramo interventricular subsinuoso, a forma de dominância coronariana foi predominantemente direita. Conclui-se que a morfologia e distribuição das artérias coronárias de javalis se assemelham à do homem e, desse modo, nossos resultados são úteis para sua concepção da hemodinâmica experimental, e possível utilização como modelos processuais.(AU)


Subject(s)
Animals , Blood Circulation , Coronary Vessels , Sus scrofa/anatomy & histology
16.
Rev. bras. cineantropom. desempenho hum ; 20(5): 381-390, Sept.-Oct. 2018. tab
Article in English | LILACS | ID: biblio-977442

ABSTRACT

Verification of the auscultatory pulse in total blood flow restriction (BFR) has been a limiting factor in studies due to the way in which it is evaluated and prescribed, as hemodynamic measurements can be directly affected by gravity. The aim of the present study was to compare the auscultatory pulse in BFR between positions, genders, limbs and body segments in healthy young individuals. A total of 156 subjects participated in the study, 76 of whom were male and 80 of whom were female (23.9±3.7 years, 66.5±11.5 kg, 1.67±0.07 m). After filling in registration data, anthropometry was evaluated, and BFR pressure was determined. BFR was evaluated in a randomized manner in both limbs (upper and lower) and in both segments (right and left) in the following positions: a) lying in the supine position; B) sitting with knees and trunk at 90°; and c) standing in the anatomical position. Significant differences were observed between the lying, sitting and standing positions (p<0.05), between genders (p<0.05), between limbs (p<0.05) and between the right and left segments in the lower limb in both genders [males (p=0.014) and females (p=0.009)] in the lying position. However, no significant differences were observed between the right and left segments in the upper limbs (p>0.05). The BFR point appears to differ between positions, genders, lower limbs and segments. Therefore, it is recommended that health professionals should check the BFR point in the position relating to the exercise that will be performed, taking into account gender, lower limbs and body segments.


A verificação do pulso auscultatório da restrição de fluxo sanguíneo (RFS) total tem sido fator limitante dos estudos devido à forma de avaliação e prescrição, já que as medidas hemodinâmicas podem sofrer influência direta da gravidade. O objetivo do presente estudo foi comparar o pulso auscultatório da RFS entre as posições, sexo, membros e segmentos corporais em jovens saudáveis. Participaram do estudo 156 sujeitos, sendo 76 homens e 80 mulheres (23,9±3,7 anos, 66,5±11,5 kg, 1,67±0,07 m). Após o preenchimento da ficha cadastral, foram avaliadas a antropometria e em seguida houve a determinação da pressão de RFS. A RFS foi avaliada de forma randomizada em ambos os membros (superiores e inferiores) e ambos os segmentos (direito e esquerdo) nas posições: a) deitada em decúbito dorsal; b) sentada com joelhos e tronco em 90°; e c) em pé na posição anatômica. Observaram-se diferenças significativas entre as posições deitado, sentado e em pé (p<0,05), entre os sexos (p<0,05), entre os membros (p<0,05) e entre os segmentos direito vs. esquerdo no membro inferior em ambos os sexos [homem (p=0,014) e mulher (p=0,009)] na posição deitada. Entretanto, observou-se não existir diferenças significativas entre os segmentos direito vs. esquerdo no membro superior (p>0,05). O ponto da RFS parece diferir entre as posições, sexo, membros inferiores e segmentos. Portanto, recomenda-se que os profissionais da área da saúde devam verificar o ponto da RFS na posição referente ao exercício que será realizado, levando em consideração o sexo, membros inferiores e segmentos corporais.


Subject(s)
Humans , Male , Female , Adult , Blood Circulation , Blood Pressure , Posture , Lower Extremity , Upper Extremity , Gender Identity
18.
São Paulo; s.n; s.n; 2018. 71 p. tab, graf.
Thesis in Portuguese | LILACS | ID: biblio-998706

ABSTRACT

As intoxicações decorrentes do uso de drogas de abuso representam atualmente um grave problema para a saúde pública. Dentre os principais agentes envolvidos, destaca-se a cocaína. Ela se tornou uma das drogas mais consumidas ao redor do mundo, sendo um dos principais motivos de atendimentos em pronto-socorro (PS) devido ao uso de substâncias ilícitas. Seu uso ocorre principalmente em associação com bebida alcóolica. Existem poucos estudos realizados que relacionem a concentração sanguínea de cocaína e a gravidade das manifestações clínicas em populações que a utilizam como droga de abuso, e que envolvam pacientes atendidos em PS. O objetivo do presente estudo foi verificar a possível relação entre concentração sanguínea de cocaína e cocaetileno (produto da interação de cocaína com etanol) com a gravidade das manifestações clínicas apresentadas por pacientes com hipótese diagnóstica de intoxicação por cocaína. As concentrações sanguíneas foram determinadas por cromatografia líquida de alta eficiência (HPLC) e a gravidade das manifestações clínicas foi avaliada através do Stimulant Intoxication Score (SIS). Dos 81 pacientes incluídos no estudo 77,8% são homens com idade média de 32,5 anos ± 8,5 e SIS médio de 3,4 ± 2,5. Do total de pacientes incluídos no estudo 20 (24,7%) tiveram resultados positivos em sangue para os analitos de interesse, sendo a concentração sanguínea média de cocaína igual a 0,34 µg/mL ± 0,45 e de cocaetileno igual a 0,38 µg/mL ± 0,34. A concentração sanguínea de cocaína e cocaetileno não se mostrou informação útil para tratamento e prognóstico dos pacientes, porém a detecção no sangue destas substâncias no momento do atendimento, independentemente de sua concentração, pode ser um indicador de gravidade, mostrando que quaisquer concentrações destas substâncias devem ser consideradas potencialmente tóxicas. A aplicação do score SIS revelou-se como importante alternativa capaz de predizer a gravidade dos pacientes atendidos devido a intoxicação por cocaína de maneira rápida e simplificada


Currently, poisoning resulting from the abuse of drug represents a serious problem for public health. Among the main agents involved, cocaine stands out. It became one of the most abused drugs around the world, being one of the main reasons for visits to the emergency room due to the use of illicit substances. The use of cocaine is primarily in combination with alcoholic beverages. There are few studies that relate cocaine blood concentration and the severity of its clinical manifestations in patients attended in the Emergency Room. The aim of the present study was to verify the possible relationship between the blood concentration of cocaine and cocaethylene (product of the interaction of cocaine with ethanol) with the severity of the clinical manifestations presented by patients with cocaine intoxication. Blood levels were measured by high-performance liquid chromatography (HPLC) and the severity of clinical manifestations was assessed using the Stimulant Intoxication Score (SIS). Of the 81 patients included in the study, 77.8% were men with a mean age of 32.5 years ± 8.5 and mean of SIS 3.4 ± 2.5. From the total of patients included in the study 20 (24.7%) had positive blood results for the analytes of interest, being the mean blood concentration of cocaine equal to 0,34 µg/mL ± 0,45 and of cocaethylene equal to 0,38 µg/mL ± 0,34. The blood concentration of cocaine and cocaethylene has not been shown to be useful information for the treatment and prognosis of patients, but blood levels of these substances at the time of treatment, regardless of their concentration, may be an indicator of severity, showing that any concentrations of these substances should be considered as potentially toxic. The application of the SIS score proved to be an important alternative capable of predicting the severity of the patients attended due to cocaine intoxication in a fast and simplified way


Subject(s)
Humans , Male , Adult , Cocaine/adverse effects , Alcoholic Beverages/adverse effects , Blood Circulation/drug effects , Chromatography, High Pressure Liquid/methods , Substance-Related Disorders , Toxicokinetics
19.
Article in Korean | WPRIM | ID: wpr-718928

ABSTRACT

The prevalence of atherothrombotic disease continues to rise, presenting an increasing number of challenges to modern society and creating interest in functional foods. Platelet activation, adhesion, and aggregation at vascular endothelial disruption sites are key events in atherothrombotic disease. Physiological challenges such as hyperlipidemia, obesity, and cigarette smoking are associated with vascular changes underlying platelet aggregation and inflammatory processes. However, it is difficult to determine the beneficial response of functional foods in healthy subjects. To address this problem, challenge models and high-risk models related to smokers, obesity, and dyslipidemia are proposed as sensitive measures to evaluate the effects of functional foods in healthy subjects. In this review, we construct a model to evaluate the effects of functional food such as natural products on blood flow based on a human intervention study.


Subject(s)
Atherosclerosis , Biological Products , Blood Circulation , Blood Vessels , Dyslipidemias , Functional Food , Healthy Volunteers , Humans , Hyperlipidemias , Obesity , Platelet Activation , Platelet Aggregation , Prevalence , Smoking
20.
Article in English | WPRIM | ID: wpr-718882

ABSTRACT

Corticotomy was introduced as a surgical procedure to shorten orthodontic treatment time. Corticotomy removes the cortical bone that strongly resists orthodontic force in the jaw and keeps the marrow bone to maintain blood circulation and continuity of bone tissues to reduce risk of necrosis and facilitate tooth movement. In the 21st century, the concept of regional acceleratory phenomenon was introduced and the development of the skeletal anchorage system using screw and plate enabled application of orthopedic force beyond conventional orthodontic force, so corticotomy has been applied to more cases. Also, various modified methods of minimally invasive techniques have been introduced to reduce the patient's discomfort due to surgical intervention and complications after surgery. We will review the history of corticotomy, its mechanism of action, and various modified procedures and indications.


Subject(s)
Blood Circulation , Bone and Bones , Bone Marrow , Jaw , Necrosis , Orthopedics , Tooth Movement Techniques , Tooth
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