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1.
Rev. baiana saúde pública ; 45(3,supl.n.esp): 118-129, 28 dec. 2021.
Article in Portuguese | LILACS | ID: biblio-1352341

ABSTRACT

A síndrome de Rendu-Osler-Weber, ou telangiectasia hemorrágica hereditária (THH), é uma doença autossômica dominante de penetrância variável que altera a camada muscular e elástica da parede dos vasos sanguíneos, causando neles grande fragilidade e dilatação e tornando-os suscetíveis a sangramentos secundários, a traumatismos e malformações arteriovenosas (MAV) ­ sendo elas as mais comuns no cérebro, nos pulmões e no trato gastrointestinal e hepático. Este relato de caso tem como objetivo realizar uma revisão sobre essa síndrome, bem como a respeito da melhor terapia e do melhor manejo para sangramentos gastrointestinais por angiectasias. Trata-se de uma paciente de 62 anos de idade, com episódio de hematêmese e melena recorrentes, que foi admitida instável hemodinamicamente e com queda importante dos níveis de hemoglobina, necessitando de múltiplas transfusões sanguíneas. Após entrevista clínica, que chamou a atenção para o histórico familiar de quadros similares, epistaxes recorrentes associados ao exame físico e angiectasias gástricas à endoscopia digestiva alta, foi atribuído o diagnóstico de síndrome de Rendu-Osler-Weber. Angiectasias foram erradicadas com terapia endoscópica usando plasma de argônio. A THH é uma doença subdiagnosticada que merece atenção especial por conta do seu risco de causar hemorragias graves com expressão fenotípica mais aflorada com o avançar da idade. Por seu cunho hereditário, faz-se necessário um acompanhamento médico linear com a família para evitar complicações secundárias da doença, bem como para o manejo adequado de suas apresentações.


Osler-Weber-Rendu syndrome or hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease that changes the muscular and elastic layer of the blood vessel wall, making them fragile and more susceptible to bleeding secondary to trauma and arteriovenous malformations (AVM) ­ a condition that commonly affects the brain, lungs, gastrointestinal tract, and liver. This study aims to perform a literature review on this syndrome, as well as on the best treatment and management for gastrointestinal bleeding from angioctasia. To this end, it reports the case of a 62-year-old female patient with recurrent episodes of hematemesis and melena, who was admitted to hospital with hemodynamic instability and low hemoglobin levels, requiring multiple blood transfusions. After clinical interview, which indicated family history of recurrent epistaxis, physical examination, and upper digestive endoscopy showing gastric angiectasias, the patient was diagnosed with Osler-Weber-Rendu syndrome. Angiectasias were treated with endoscopic argon plasma. Considering the risk of severe hemorrhages and its more pronounced phenotypic expression with advancing age, HHT is an underdiagnosed disease that deserves special attention. Due to its hereditary nature, a linear medical follow-up with the family is necessary to avoid secondary complications of the disease, as well as the proper management of its presentations.


El síndrome de Rendu-Osler-Weber o telangiectasia hemorrágica hereditaria (THH) es una enfermedad autosómica dominante de penetrancia variable, que modifica la capa muscular y elástica de la pared de los vasos sanguíneos, provocando una gran fragilidad y dilatación de estas, haciéndolas susceptibles a hemorragias secundarias a trauma y malformaciones arteriovenosas (MAV), que son las más comunes en el cerebro, pulmones, tracto gastrointestinal e hígado. Este estudio tiene como objetivo realizar una revisión de este síndrome, así como la mejor terapia y manejo del sangrado gastrointestinal por angioctasia en esta patología. Se trata de un paciente de 62 años, con episodio de hematemesis recurrente y melena, que ingresa hemodinámicamente inestable y con descenso significativo de los niveles de hemoglobina, requiriendo múltiples transfusiones sanguíneas. Tras entrevista clínica, destacando los antecedentes familiares de patologías similares, epistaxis recurrente, exploración física y angiectasias gástricas a endoscopia digestiva alta, se asignó el diagnóstico de síndrome de Rendu-Osler-Weber. Las angiectasias se erradicaron con terapia endoscópica con plasma de argón. La HHT es una enfermedad infradiagnosticada que merece una atención especial por su riesgo de hemorragias severas, con una expresión fenotípica más pronunciada con el avance de la edad. Además de su carácter hereditario, es necesario un seguimiento médico lineal con la familia para evitar complicaciones secundarias de la enfermedad, así como el adecuado manejo de sus presentaciones.


Subject(s)
Humans , Arteriovenous Malformations , Telangiectasia, Hereditary Hemorrhagic , Blood Vessels , Gastrointestinal Tract
2.
Gac. méd. Méx ; 157(2): 166-173, mar.-abr. 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1279097

ABSTRACT

Resumen Introducción: Distintos protocolos de angiotomografía de coherencia óptica evalúan la mácula. Objetivo: R2) entre las densidades vascular y de perfusión de dos protocolos de angiotomografía de coherencia óptica, para determinar si sus mediciones podían intercambiarse. Método: Estudio observacional, comparativo, prospectivo, transversal entre dos protocolos de angiotomografía de coherencia óptica (AngioPlex, Zeiss) en sujetos sanos. Se identificó la R2 entre las densidades vascular y de perfusión central, interna y completa (protocolo de 3 x 3 mm), y central, interna, externa y completa (protocolo de 6 x 6 mm). Resultados: 78 ojos, mediana de edad 23 años. Hubo R2 altas entre las densidades interna y completa del protocolo de 3 x 3 mm (0.96), externa y completa del de 6 x 6 mm (0.96), y centrales vasculares y de perfusión (≥ 0.96); la R2 entre las densidades centrales vascular y de perfusión de distintos protocolos fue ≤ 0.71. Conclusiones: Las densidades vasculares y de perfusión tienen R2 alta dentro de un protocolo, pero no entre protocolos, porque estos miden preferentemente zonas distintas, lo cual limita intercambiar mediciones.


Abstract Introduction: Different optical coherence tomography angiography (OCTA) scanning protocols evaluate the macula. Objective: To compare the determination coefficients (R2) between vessel and perfusion densities of two OCTA scanning protocols, to learn whether their metrics could be interchanged. Method: Non-experimental, comparative, prospective, observational, cross-sectional study, between two OCTA scanning protocols (Angioplex, Zeiss) in healthy subjects. We found the R2 between central, inner, and full densities (3 x 3 mm protocol), and between central, inner, outer and full densities (6 x 6 mm protocol), both for vessel and perfusion densities. Results: 78 eyes, median age 23 years. There were high R2 between inner and full densities in the 3 x 3 mm protocol (0.96), between outer and full densities in the 6 x 6 mm protocol (0.96) and between central vessel and perfusion densities (≥0.96); R2 between central vessel and perfusion densities of different protocols (≤0.71). Conclusions: Vessel and perfusion densities have high determination coefficients within a scanning protocol, but not between protocols, because each preferentially measures different macular areas. The metrics of different protocols should not be interchanged for follow-up.


Subject(s)
Humans , Male , Female , Adult , Young Adult , Angiography/methods , Tomography, Optical Coherence/methods , Macula Lutea/blood supply , Regional Blood Flow/physiology , Blood Vessels/diagnostic imaging , Visual Acuity , Cross-Sectional Studies , Prospective Studies , Statistics, Nonparametric , Healthy Volunteers , Macula Lutea/diagnostic imaging
3.
Rev. cuba. angiol. cir. vasc ; 22(1): e206, ene.-abr. 2021. fig
Article in Spanish | LILACS, CUMED | ID: biblio-1251683

ABSTRACT

El hemangioma cavernoso es una neoplasia benigna de los vasos sanguíneos. Este trabajo tuvo como objetivo presentar el caso de un hemangioma cavernoso gigante que fue tratado con propranolol. El diagnóstico se realizó mediante examen físico, dúplex y otros complementarios de interés. Para la decisión de la conducta terapéutica, especialistas de diferentes especialidades evaluaron al paciente: Oncología, Dermatología, Ortopedia, Pediatría y Angiología. Una vez establecido el tratamiento, se realizó un seguimiento durante cuatro semanas y luego mensual. El resultado, después de 22 meses, fue la desaparición del hemangioma. El propranolol en el hemangioma cavernoso gigante debe ser el tratamiento de elección precoz para una evolución satisfactoria y evitar complicaciones(AU)


Cavernous hemangioma is a benign neoplasm of blood vessels. This work aimed at presenting the case of a giant cavernous hemangioma treated with propranolol. The diagnosis was made by physical examination, duplex Doppler sonography, and complementary tests of interest. For deciding the therapeutic approach, the patient was assessed by several specialists from different medical fields, such as oncology, dermatology, orthopedics, pediatrics, and angiology. Once the treatment was established, a follow-up was carried out for four weeks and then monthly. The outcome, after twenty-two months, was the hemangioma disappearance. Propranolol in giant cavernous hemangioma should be the treatment of early choice for a satisfactory evolution and to avoid complications(AU)


Subject(s)
Humans , Male , Female , Blood Vessels , Hemangioma , Hemangioma, Cavernous , Neoplasms , Aftercare
5.
Ciênc. cuid. saúde ; 20: e50127, 2021. graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1339643

ABSTRACT

RESUMO Objetivo: analisar os estudos científicos desenvolvidos sobre a deficiência de vitamina D e a mortalidade por causa cardiovascular nas pessoas com doença renal crônica. Método: Trata-se de uma revisão integrativa da literatura a partir das bases de dados LILACS, Pub Med, Medline e na biblioteca eletrônica SciELO, utilizando os descritores deficiência de vitamina D, mortalidade cardiovascular e doença renal crônica, sendo selecionados 14 artigos para análise. Resultados: A partir da análise dos artigos selecionados, foi possível identificar que a deficiência de vitamina D e a mortalidade cardiovascular são condições muito frequentes em renais crônicos e, por isso, discutem-se hipóteses de que a correção desta deficiência pode exercer efeitos benéficos sobre a doença e mortalidade cardiovascular nessa população. Conclusão: Há uma intrínseca relação entre a carência de vitamina D e a mortalidade cardiovascular. Entretanto, ainda é discutível se a suplementação de vitamina D reduz a mortalidade cardiovascular nos doentes renais crônicos. Tal hipótese precisa ser testada em ensaios clínicos, ensejando a necessidade de se desenvolver mais pesquisas sobre o tema.


RESUMEN Objetivo: analizar los estudios científicos desarrollados sobre la deficiencia de vitamina D y la mortalidad por causa cardiovascular en las personas con enfermedad renal crónica. Método: se trata de una revisión integradora de la literatura a partir de las bases de datos LILACS, PubMed, Medline yen la biblioteca electrónica SciELO, utilizando los descriptores deficiencia de vitamina D; mortalidad cardiovascular y enfermedad renal crónica, siendo seleccionados 14 artículos para el análisis. Resultados: a partir del análisis de los artículos seleccionados, fue posible identificar que la deficiencia de vitamina D y la mortalidad cardiovascular son condiciones muy frecuentes en enfermos renales crónicos y, por ello, se discuten hipótesis de que la corrección de esta deficiencia puede ejercer efectos benéficos sobre la enfermedad y mortalidad cardiovascular en esta población. Conclusión: hay una intrínseca relación entre la carencia de vitamina D y la mortalidad cardiovascular. Sin embargo, aúnes discutible si la suplementación de vitamina D reduce la mortalidad cardiovascular en los enfermos renales crónicos. Tal hipótesis necesita ser probada en ensayos clínicos, fomentando la necesidad de desarrollarse más investigaciones sobre el tema.


ABSTRACT Objective: To analyze scientific studies that have addressed vitamin D deficiency and cardiovascular mortality in people with chronic kidney disease. Method: This is an integrative literature review conducted through the LILACS, PubMed and Medline databases, and through the SciELO electronic library, using the 'vitamin D deficiency', 'cardiovascular mortality' and 'chronic kidney disease' descriptors, with 14 articles being selected for analysis. Results: By analyzing the selected articles, it was possible to identify that vitamin D deficiency and cardiovascular mortality are very common conditions in chronic renal patients and, for this reason, there are hypotheses that correcting this deficiency may have beneficial effects on the disease and cardiovascular mortality in this population. Conclusion: There is an intrinsic relationship between vitamin D deficiency and cardiovascular mortality. However, it is still debatable whether vitamin D supplementation reduces cardiovascular mortality in chronic renal patients. Such hypothesis needs to be tested in clinical trials, which gives cause for the need to develop further research on the theme.


Subject(s)
Humans , Male , Female , Vitamin D Deficiency , Mortality , Renal Insufficiency, Chronic , Patients , Vitamin D , Blood Vessels , Chronic Disease , Death
6.
Int. j. morphol ; 38(6): 1735-1741, Dec. 2020. tab, graf
Article in English | LILACS | ID: biblio-1134506

ABSTRACT

SUMMARY: The aim of this study was to perform an in situ endoscopic analysis of the vascularization of post-extraction sites immediately after a non-traumatic extraction in terms of the number of blood vessels per field (NBV), relative area of blood vessels (RABV) and relative area of unmineralized bone (RAUB) in teeth with different periodontal status (PS). This assessment was performed using short distance support immersion endoscopy (SD-SIE). Ten patients (4 men/ 6 women, aged between 25 and 44) were selected. From them, 10 teeth were extracted due to periodontal reasons or other motives. These teeth were then categorized into 2 groups according to their PS, either as periodontally compromised (PC) (clinical attachment loss (CAL) > 7 mm and probing depth (PD) > 5 mm) or periodontally healthy (PH) (CAL < 7 mm and PD < 5 mm, without bleeding or suppuration during periodontal probing), and mobile (M) (> 1 mm horizontally) or immobile (I) (< 1 mm horizontally). The minimally invasive vertical tooth extractions were performed using the Benex ® extractor. Immediately after extraction, a rigid immersion endoscope with a diameter of 2.7 mm was introduced, and a video-alveoloscopy was carried out. This video was analyzed by ImageJ software for the quantification of NBV, RABV and RAUB per field of the post-extraction sites with different PS (PC, PH, M, I) were quantified. In the PC group, significantly greater values for RAUB were observed (33.45 %) compared to those from the PH group (19.65 %). Compared with the M group, the I group did not show significant differences in terms of RAUB or RABV. There were also no differences in NBV in both groups (Means: 33.8 vs. 30.5, respectively).


RESUMEN: El objetivo de este estudio fue realizar un análisis endoscópico in situ de la vascularización de los alvéolos post-extracción inmediatamente después de una extracción atraumática en términos de número de vasos sanguíneos por campo de observación (NBV), área relativa de vasos sanguíneos (RABV) y el área relativa de espacios no mineralizados (RAUB) en dientes con diferente estado periodontal (PS). Esta evaluación se realizó mediante endoscopía de inmersión de corta distancia (SD-SIE). Se seleccionaron diez pacientes (4 hombres / 6 mujeres, con edades comprendidas entre 25 y 44). De ellos, se extrajeron 10 dientes debido a razones periodontales u otros motivos. Estos dientes se clasificaron en 2 grupos según su PS, ya sea como periodontalmente comprometidos (PC), los que presentaban un nivel de inserción clínica (CAL) ≥ 7 mm y una profundidad de sondaje (PD) ≥ 5 mm; o periodontalmente sanos (PH) (CAL <7 mm y PD <5 mm, sin sangramiento o supuración durante el sondaje periodontal). También se categorizaron según su movilidad como móvil (M) (≥ 1 mm horizontalmente) o inmóvil (I) (<1 mm horizontalmente). Las extracciones verticales mínimamente invasivas se realizaron con el extractor Benex ®. Inmediatamente después de la extracción, se introdujo un endoscopio rígido de inmersión con un diámetro de 2.7 mm, con el cual se realizó una video-alveoloscopía. Este video fue analizado por el software ImageJ para la cuantificación de NBV, RABV y RAUB por campo, de los alvéolos post-extracción con diferente estado periodontal. En el grupo de dientes PC, se observaron valores significativamente mayores para RAUB (33.45%) en comparación con los del grupo PH (19.65 %). En comparación con el grupo M, el grupo I no mostró diferencias significativas en términos de RAUB o RABV. Tampoco hubo diferencias en el NBV en ambos grupos (Media: 33.8 frente a 30.5, respectivamente).


Subject(s)
Humans , Male , Female , Adult , Tooth Extraction , Blood Vessels , Bone and Bones/blood supply , Tooth Socket/blood supply , Endoscopy/methods , Neovascularization, Physiologic
7.
Rev. ADM ; 77(6): 287-294, nov.-dic. 2020. ilus, tab
Article in Spanish | LILACS | ID: biblio-1150870

ABSTRACT

Introducción: El carcinoma oral de células escamosas (COCE) es una neoplasia epitelial maligna que se presenta frecuentemente entre la quinta y sexta década de la vida. Su compleja patogénesis incluye el proceso de angiogénesis y la regulación del microambiente tumoral como mecanismos de progresión tumoral. Objetivo: Determinar la relación entre las variables clínicas e histológicas del COCE con la inmunoexpresión de VEGF, FGF-1, FGFR-1, TGFB-1, TGFBR-II y CD105. Material y métodos: Nueve casos de COCE; tres bien (BD), tres moderado (MD) y tres pobremente diferenciados (PD) obtenidos del Departamento de Patología y Medicina Bucal, División de Estudios de Postgrado e Investigación. Se aplicó la técnica de inmunohistoquímica por peroxidasa para identificar la expresión de VEGF, FGF-1, FGFR- 1, TGFB-1, TGFBR-II y CD105. El análisis de inmunoexpresión se realizó con el programa ImageJ. Se aplicó la prueba de Kruskal-Wallis y correlación de Spearman (p < 0.05). Resultados: La inmunoexpresión de VEGF fue mayor en los COCE PD, FGFR-1 fue positivo en los BD, mientras que FGF, TGFB-1 y TGFBR-II fueron negativos. El análisis de microdensidad vascular (MVD) indicó mayor número de vasos CD105 positivos en los carcinomas BD, seguidos de los PD y MD. Conclusión: Considerando los resultados obtenidos podemos concluir que la angiogénesis es un fenómeno constante independiente del grado de diferenciación que durante el proceso de transformación de una neoplasia requerirá la formación de vasos sanguíneos y que este proceso puede ser modulado por factores de crecimiento tales como los analizados en este trabajo (AU)


Introduction: Oral squamous cell carcinoma (OSCC) is a malignant epithelial neoplasm that frequently occurs between the fifth and sixth decade of life. Its complex pathogenesis includes the angiogenesis process and the regulation of the tumor microenvironment as mechanisms of tumor progression. Objective: To determine the relationship between the clinical and histological variables of OSCC with the immunoexpression of VEGF, FGF-1, FGFR-1, TGFB- 1, TGFBR-II and CD105. Material and methods: Nine cases of OSCC; three well (WD), three moderate (MD) and three poorly differentiated (PD) obtained from the Oral Medicine and Pathology Department, Division of Graduate Studies and Research. The peroxidase immunohistochemistry technique was performed to identify the expression of VEGF, FGF-1, FGFR-1, TGFB-1, TGFBR-II and CD105. The immunoexpression analysis was performed with the ImageJ software. The Kruskal-Wallis and Spearman correlation test were performed (p < 0.05). Results: VEGF immunoexpression was higher in PD OSCC, while FGFR-1 was predominantly positive in WD; FGF, TGFB-1 and TGFBR-II were negative. Vascular microdensity analysis (MVD) indicated a greater number of CD105 positive vessels in WD carcinomas, followed by PD and MD. Conclusion: Considering the results obtained, we can conclude that angiogenesis is a constant phenomenon independent of the degree of differentiation; that during the transformation process of a neoplasm it will require the formation of blood vessels and that this process can be modulated by growth factors such as those analyzed in this work (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Carcinoma, Squamous Cell/immunology , Fibroblast Growth Factor 1 , Vascular Endothelial Growth Factor A , Blood Vessels , Immunohistochemistry , Statistical Analysis , Histological Techniques , Intercellular Signaling Peptides and Proteins , Receptor, Fibroblast Growth Factor, Type 1 , Endoglin , Mexico
9.
Acta méd. colomb ; 45(2): 45-48, Jan.-June 2020. graf
Article in English | LILACS, COLNAL | ID: biblio-1130691

ABSTRACT

Moyamoya disease is a chronic neurovascular disease characterized by progressive bilateral stenosis of the internal carotid arteries with abnormal formation of new abnormal blood vessels whose blockage of blood flow causes a variety of clinical manifestations and complications associated with acute cerebrovascular events (ischemic or hemorrhagic), which may even be fatal. This article seeks to describe this entity, its incidence, prevalence, forms of presentation, therapeutic measures and prognosis through a clinical case report. (Acta Med Colomb 2020; 45. DOI:http://doi.org/10.36104/amc.2020.1424).


La enfermedad de Moyamoya es una enfermedad neurovascular crónica caracterizada por una estenosis progresiva bilateral de las arterias carótidas internas, con la formación anormal de nuevos vasos sanguíneos, cuyo bloqueo en flujo sanguíneo ocasiona variadas manifestaciones clínicas y complicaciones asociadas a eventos cerebrovasculares (isquémicos o hemorrágicos) agudos que pueden llegar a ser incluso mortales. El presente artículo pretende realizar una aproximación acerca de esta entidad, su incidencia, prevalencia, formas de presentación y medidas terapéuticas y pronostico mediante el reporte de un caso clínico.(Acta Med Colomb 2020; 45. DOI:https://doi.org/10.36104/amc.2020.1424).


Subject(s)
Humans , Female , Adult , Moyamoya Disease , Prognosis , Blood Vessels , Carotid Arteries , Cerebrovascular Disorders , Prevalence , Basal Ganglia Cerebrovascular Disease
11.
Niger. J. Dent. Res ; 5(2): 94-98, 2020. ilus
Article in English | AIM, AIM | ID: biblio-1266992

ABSTRACT

Objective: A haemangioma is a benign vascular tumour consisting of an abnormal overgrowth of tiny blood vessels. Haemangioma may not be present at birth but may appear at 6 months of life. This vascular tumour is not common. We therefore report fifteen cases of haemangioma occurring in the oro-facial region: eight occurred in the cheek, one in the floor of the mouth, four in the lower lip and two in the maxillary gingivae. The objective of this study was to outline the clinical presentation and management of haemangioma in the oro-facial region treated in our Centre. Methods: This is a retrospective study of all the patients that were treated from July, 2009 to July, 2019. Information was extracted from case files of patients. Data collected included: age at presentation, sex, location of the tumour, treatment given, findings and histological diagnosis. Results: The result showed fifteen cases, nine (60.0%) were males and six (40.0%) females. Male to female ratio is 1.50 to 1.00. Our diagnostic tool was the aspiration of frank blood from the tumour which had similar clotting time with the normal blood and our mode of treatment included: injection of sclerosants and excision of the fibrous tissues. Conclusion: It is essential to treat the tumour as early as possible especially in large lesion with disfigurement or where it is complicated by haemorrhage or infection


Subject(s)
Blood Vessels , Cheek , Hemangioma , Neoplasms
12.
Int. j. odontostomatol. (Print) ; 14(3): 373-379, 2020. tab, graf
Article in English | LILACS | ID: biblio-1114910

ABSTRACT

Benign oral vascular lesions are anomalies characterized by the blood vessels proliferation or malformation and the treatment with the sclerosing agent ethanolamine oleate acts irrigating the vessel producing a sterile inflammatory response. The objective of this study was to report and discuss the results from treatment of benign oral vascular lesions with non-diluted ethanolamine oleate through the analysis of clinical records. The sample was composed by the selection of twenty-six patients (12 male and 14 female), with oral vascular malformations. All lesions were treated with intralesional injections of undiluted ethanolamine oleate. These patients attended in Oral Medicine outpatient clinic of the Federal University of Paraná between the years of 2011 to 2015. The average age was 60.65 years, with a higher prevalence for women. The majority of the individuals had one lesion and its location was mostly in the lower lip. The main complaint was about a physical discomfort. The lesions had the average size of 6.52 mm and received a median number of 2.32 applications. Only one patient reported feeling pain in the postoperative week. In most cases the resolution of the lesion was considered partial. Follow-up was obtained up to one month after the end of treatment. The sclerotherapy with undiluted ethanolamine oleate shows acceptable results in the treatment of small benign oral vascular lesions with a few minor side effects.


Las lesiones vasculares orales benignas son anomalías caracterizadas por la proliferación o malformación de los vasos sanguíneos y el tratamiento con el agente esclerosante etanolamina oleato actúa irrigando el vaso produciendo una respuesta inflamatoria estéril. El objetivo de este estudio fue informar y discutir los resultados del tratamiento de lesiones vasculares orales benignas con oleato de etanolamina no diluido a través del análisis de historias clínicas. La muestra estuvo compuesta por la selección de veintiséis pacientes (12 hombres y 14 mujeres), con malformaciones vasculares orales. Todas las lesiones fueron tratadas con inyecciones intralesionales de oleato de etanolamina sin diluir. Estos pacientes acudieron a la clínica ambulatoria de Medicina Oral de la Universidad Federal de Paraná entre los años 2011 a 2015. La edad promedio fue de 60,65 años, con una mayor prevalencia para las mujeres. La mayoría de los individuos tenían una lesión y su ubicación era principalmente en el labio inferior. La queja principal era sobre una molestia física. Las lesiones tenían un tamaño promedio de 6,52 mm y recibieron una mediana de 2,32 aplicaciones. Solo un paciente informó haber sentido dolor en la semana postoperatoria. En la mayoría de los casos, la resolución de la lesión se consideró parcial. El seguimiento se obtuvo hasta un mes después del final del tratamiento. La escleroterapia con oleato de etanolamina sin diluir muestra resultados aceptables en el tratamiento de pequeñas lesiones vasculares orales benignas con algunos efectos secundarios menores.


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Aged , Young Adult , Oleic Acids/administration & dosage , Sclerotherapy/methods , Ethanolamine/administration & dosage , Vascular Malformations/therapy , Mouth Diseases/therapy , Sclerosing Solutions/administration & dosage , Blood Vessels/abnormalities , Mouth Neoplasms/therapy , Injections, Intralesional , Follow-Up Studies , Treatment Outcome , Patient Satisfaction , Hemangioma/therapy , Lip/blood supply
13.
Annals of Dermatology ; : 146-150, 2020.
Article in English | WPRIM | ID: wpr-811083

ABSTRACT

Solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal neoplasm that usually arises in the pleura, but also has been reported in numerous extrapleural locations, including cutaneous site. The skin lesion presents as a circumscribed nodule or tumor, mainly on the head and neck. A 41-year-old male presented with 6 months history of nail lesion without symptom on the left third finger. The lesion is slightly yellowish discoloration with subungual erythematous nodule and distal onycholysis. Biopsy specimen from the nail lesion showed the spindle cells form patternless pattern with hypercellular and hypocellular area. And small blood vessels and dilated vascular spaces were present. The result of special stain for specimen showed that positive for CD34, Bcl-2, and CD99 but negative for S-100, FactorXIIIa, and smooth muscle action. Recognition of this uncommon location of SFT is important because of possible confusion with other subungual tumors, including glomus tumor, fibroma and other fibrohistiocytic tumors like dermatofibrosarcoma protuberans, superficial acral fibromyxoma and cellular digital fibroma. Here in, we report a case of SFT of subungual region. We think this case is interesting because of uncommon location and may be helpful to more understand the character of this disease.


Subject(s)
Adult , Biopsy , Blood Vessels , Dermatofibrosarcoma , Fibroma , Fingers , Glomus Tumor , Head , Humans , Male , Muscle, Smooth , Neck , Onycholysis , Pleura , Skin , Solitary Fibrous Tumors
14.
Annals of Dermatology ; : 164-167, 2020.
Article in English | WPRIM | ID: wpr-811079

ABSTRACT

Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been widely known as causative agents. The most common clinical feature of drug-induced vasculitis is palpable purpura on lower extremities. A 66-year-old Korean female presented with erythematous nodules on upper chest and back. She had been on medication for multiple myeloma. Laboratory results showed neutropenia. After a single injection of filgrastim (recombinant granulocyte colony-stimulating factor), she developed cutaneous lesions with concurrent increase in absolute neutrophil count. A skin biopsy revealed leukocytoclastic vasculitis. After discontinuation of filgrastim injection, her skin lesions disappeared spontaneously.


Subject(s)
Aged , Allopurinol , Biopsy , Blood Vessels , Female , Filgrastim , Granulocyte Colony-Stimulating Factor , Granulocytes , Humans , Hydralazine , Inflammation , Lower Extremity , Multiple Myeloma , Neutropenia , Neutrophils , Propylthiouracil , Purpura , Skin , Thorax , Vasculitis , Vasculitis, Leukocytoclastic, Cutaneous
15.
Int. j. morphol ; 37(4): 1404-1408, Dec. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1040145

ABSTRACT

Las glándulas tiroides consisten en dos partes denominadas lobos que se encuentran en ambos lados de la laringe. El objetivo de este estudio fue caracterizar las medidas, topografía y vascularización de la glándula tiroides de conejos Nueva Zelanda. Las disecciones anatómicas se realizaron en 36 cadáveres adultos, 17 machos y 19 hembras, con masa corporal media de 2,5 kg y longitud cara-sacral media de 40 cm. Los cadáveres fueron obtenidos del sector de necropsia de la Universidad. Los especímenes tuvieron la arteria aorta torácica canalada, por la cual se inyectó solución de formaldehído al 10 %, seguida de látex coloreado. En los machos, el lobo izquierdo de la glándula tiroidea midió 1,40 x 0,40 x 0,01 cm y el derecho 1,36 x 0,56 x 0,01 cm; en las hembras, el lobo izquierdo midió 1,50 x 0,49 x 0,01 cm y el derecho 1,37 x 0,48 x 0,01cm. No hubo diferencia significativa (p> 0,05) entre las medias de las medidas entre machos y hembras, pero la extensión del lóbulo izquierdo de las hembras y la anchura del lóbulo derecho de los machos fueran significativamente mayores (p <0,05). La extremidad craneal de los lobos tiroideos se encontraba al nivel del cartílago cricoide en casi todos los especímenes. El extremo caudal presentó topografía más variable, desde el tercer hasta el décimo anillo traqueal, habiendo predominado al nivel del quinto anillo. Invariablemente, la irrigación arterial fue determinada por las arterias tiroideas izquierda y derecha, originadas de la arteria carótida común. Las anastomosis entre las arterias tiroideas fueron comunes. La constancia en las dimensiones y irrigación de la glándula tiroidea puede ser ventajosa en la elección del Coelho como modelo experimental para el estudio de esta glándula.


The thyroid glands consist of two parts called lobes located on both sides of the larynx. The aim of this study was to characterize the measures, topography and arterial irrigation of New Zealand´s rabbits thyroid glands. The anatomical dissections were performed in 36 adult cadavers, 17 males and 19 females, with a mean body mass of 2.5 kg and a mean cranium-sacral length of 40 cm. The specimens were obtained from the necropsy unit of the University. The cadavers had the thoracic aorta artery cannulated, through which 10 % formaldehyde solution was injected, followed by injection colored latex. In males, the left lobe of the thyroid gland measured 1.40x0.40x0.01cm and the right 1.36x0.56x0.01cm; in females, the left lobe measured 1.50x0.49x0.01cm and the right one was 1.37x0.48x0.01cm. There was no significant difference (p> 0.05) between the means of the measurements between males and females, but the left lobe length of the females and the right lobe width of the males were significantly higher (p <0.05). The cranial extremity of the thyroid lobes was at the level of the cricoid cartilage in almost all specimens. The caudal end showed more variable topography, from the third to the tenth tracheal ring in few specimens, but predominated at the level of the fifth ring. Invariably, arterial irrigation was determined by the left and right thyroid arteries, originating from the common carotid artery. Anastomoses between the thyroid arteries were common. The constancy in dimensions and irrigation of the thyroid gland may be advantageous in choosing the rabbit as an experimental model for the study of this gland.


Subject(s)
Animals , Male , Female , Rabbits/anatomy & histology , Thyroid Gland/blood supply , Blood Vessels/anatomy & histology , Sex Characteristics , Thyroid Gland/anatomy & histology
16.
Acta cir. bras ; 34(10): e201901005, Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1054671

ABSTRACT

Abstract Purpose: To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control). Methods: We obtained 132 specimens from samples of prostate peripheral and transition zone. We analyzed the following elements of the extracellular matrix: collagen fibers, elastic system, smooth muscle fibers and blood vessels. The tumor area and non-tumor area (control) of the TMA (tissue microarray) were photographed and analyzed using the ImageJ software. Results: The comparison between the tumor area and the non-tumor area showed significant differences between stromal prostate elements. There was an increase of collagen fibers in the tumor area, mainly in Gleason 7. Elastic system fibers showed similar result, also from the Gleason 7. Blood vessels showed a significant increase occurred in all analyzed groups. The muscle fibers exhibited a different behavior, with a decrease in relation to the tumor area. Conclusions: There is a significant difference between the extracellular matrix in prostate cancer compared to the non-tumor area (control) especially in Gleason 7. Important modifications of the prostatic stromal elements strongly correlate with different Gleason scores and can contribute to predict the pathological staging of prostate cancer.


Subject(s)
Humans , Male , Middle Aged , Aged , Aged, 80 and over , Prostatic Neoplasms/pathology , Adenocarcinoma/pathology , Stromal Cells/pathology , Reference Values , Blood Vessels/pathology , Retrospective Studies , Collagen/analysis , Tissue Array Analysis , Elastic Tissue/anatomy & histology , Neoplasm Grading , Muscle, Smooth/pathology
17.
J. bras. nefrol ; 41(3): 423-426, July-Sept. 2019. graf
Article in English | LILACS | ID: biblio-1040256

ABSTRACT

ABSTRACT Introduction: Vascular access and renal biopsy are common procedures in nephrology. In this study, two artisanal simulators of very low cost and excelent image quality are (prented) presented to guide, by ultrasound, the venous access and renal biopsy. Methods: The simulators are constructed using chicken breast slices, Penrose drain, plastic milk shake straw and pig kidney. Results: Both simulators enable immediate identification of the anatomical structures of interest, vessels and kidney, and enable spatial orientation and hand-eye coordination, essential for the development of the necessary skills to safely carry out invasive procedures. Conclusion: The simulators described, were extremely useful for simulating venous access and renal biopsy guided by ultrasonography, enabling training to reduce the failure rate in punctures and the potential complications associated with the described procedures.


RESUMO Introdução: O acesso vascular e a biópsia renal são procedimentos comuns na prática nefrológica. Neste estudo, são apresentados dois simuladores artesanais de baixo custo e excelente qualidade de imagem para guiar, ultrassonograficamente, o acesso venoso e a biópsia renal. Métodos: Os simuladores são construídos utilizando fatias de peito de frango, dreno de Penrose, canudo plástico milk shake e rim de porco. Resultados: Ambos os simuladores permitem a identificação imediata das estruturas anatômicas de interesse, vasos e rim, e possibilitam a orientação espacial e coordenação olho-mão, essenciais para o desenvolvimento das habilidades necessárias para realizar seguramente procedimentos invasivos. Conclusão: Os simuladores descritos, extremamente úteis para as simulações do acesso venoso e a biópsia renal guiados por ultrassonografia, possibilitam o treinamento objetivando a redução do insucesso das punções e das complicações potenciais associadas aos procedimentos descritos.


Subject(s)
Animals , Ultrasonography/methods , Simulation Training/methods , Nephrologists/education , Kidney/pathology , Nephrology/education , Swine , Blood Vessels , Punctures , Chickens , Clinical Competence , Muscle, Skeletal , Image-Guided Biopsy
18.
Rev. ecuat. pediatr ; 20(1): 60-62, Agosto2019.
Article in Spanish | LILACS | ID: biblio-1010315

ABSTRACT

Los defectos óseos secundarios de la tibia en los niños, por procesos infecciosos como la osteomielitis, representan un reto en su tratamiento 1, 2. Históricamente, los defectos en la tibia han sido tratados con un injerto óseo 3. Desde 1983 el uso del injerto autólogo vascularizado con regeneración de los tejidos ha dado resultados favorables 4. La forma más eficaz de estimular la osteogénesis se consigue con un injerto autólogo acompañado de una vascularidad óptima y una conexión con los tejidos blandos.


The bone defects of the tibia in children related to infectious processes such as osteomyelitis, represent a treatment challenge.1,2 Historically, defects in the tibia have been treated with a bone graft.3 Since 1983 use of vascularized autologous graft, with tissue regeneration has met with favorable results.4 The most effective form of osteogenesis is accomplished with an autologous graft accompanied by optimal vascularization and a connection with the soft tissues.


Subject(s)
Humans , Child , Osteomyelitis , Pseudarthrosis , Tibia , Blood Vessels , Tissue Transplantation , Focal Infection
19.
Article in Spanish | LILACS | ID: biblio-1003815

ABSTRACT

RESUMEN Objetivo: Evaluar la influencia de las perforaciones corticales en regeneración ósea guiada (ROG) mediante resultados de histomorfometría obtenidos de estudios humanos y animales. Revisión de la literatura actual: Se realizó una búsqueda electrónica de estudios en humanos y animales en bases de datos PubMed, Cochrane Library, SciELO y Google Scholar desde 1980 hasta mayo del 2017. Se utilizó la siguiente estrategia de búsqueda: ((decortication of bone) OR (bone decortication) OR (alveolar decortication) OR (decortication) OR (decortications) OR (cortical perforation of bone) OR (cortical bone perforation) OR (cortical perforation) OR (cortical perforations) OR (intramarrow penetration) OR (marrow penetration)) AND ((guided bone regeneration) OR (guided bone augmentation) OR (bone augmentation) OR (osseous repair) OR (graft integration)). Discusión y conclusión: Se identificaron 65 artículos y sólo se seleccionaron 8. Cuatro estudios en animales mostraron influencia estadísticamente significativa al realizar perforaciones corticales. En 3 estudios en animales y en un estudio en humanos esta diferencia no fue estadísticamente significativa. Sin embargo, al realizar perforaciones existió mayor número de vasos sanguíneos y mayor formación ósea sin reacciones inflamatorias resaltantes ni impactos negativos. Las perforaciones corticales muestran beneficios en etapas tempranas de cicatrización influyendo significativamente en la angiogénesis incrementando la cantidad de hueso neoformado.


ABSTRACT Objective: To evaluate the influence of cortical perforations on guided bone regeneration (ROG) by histomorphometry results obtained from human and animal studies. Review of current literature: An electronic search of trials in humans and animals with histomorphometric evaluations was carried out in the PubMed, Cochrane Library, SciELO and Google Scholar databases from 1980 to May 2017. The following search strategy was used: ((decortication of bone) OR (bone decortication) OR (alveolar decortication) OR (decortication) OR (decortications) OR (cortical perforation of bone) OR (cortical bone perforation) OR (cortical perforation) OR (cortical perforations) OR (intramarrow penetration) OR (marrow penetration)) AND ((guided bone regeneration) OR (guided bone augmentation) OR (bone augmentation) OR (osseous repair) OR (graft integration)). Discussion and conclusion: Sixty five articles were identified and only 8 were selected. Four studies in animals showed statistically significant influence when performing cortical perforations. In 3 studies in animals and in 1 human study this difference was not statistically significant. However, when drilling, a greater number of blood vessels and a greater bone formation without inflammatory reactions or negative impacts were recorded. Cortical perforations show benefits in early stages of healing, influencing significantly in the angiogenesis, increasing the amount of neoformed bone.


Subject(s)
Humans , Animals , Wound Healing , Blood Vessels , Bone Regeneration , Cortical Bone
20.
Article in Korean | WPRIM | ID: wpr-766745

ABSTRACT

Reversible cerebral vasoconstriction syndrome (RCVS) is a disease characterized by reversible and multiple stenoses of cerebral blood vessels that improve within 3 months, accompanied by thunderclap headache. Here, we report an interesting case of RCVS initially misdiagnosed as Moyamoya disease with transient ischemic attack. A 45-year-old woman visited the Neurology Department of Eulji University Hospital. The patient was initially diagnosed with Moyamoya disease with transient ischemic attack. However, follow-up magnetic resonance angiography performed 12 months after the patient was appropriately diagnosed as having RCVS.


Subject(s)
Blood Vessels , Constriction, Pathologic , Female , Follow-Up Studies , Headache Disorders, Primary , Humans , Ischemic Attack, Transient , Magnetic Resonance Angiography , Middle Aged , Moyamoya Disease , Neurology , Vasoconstriction
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