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1.
Rev. enferm. UERJ ; 29: e56037, jan.-dez. 2021.
Article in English, Portuguese | LILACS | ID: biblio-1151921

ABSTRACT

Objetivo: mapear as evidências disponíveis na literatura acerca dos manejos e desfechos da infecção pelo novo coronavírus no puerpério. Método: revisão de escopo conforme o Institute Joanna Briggs, desenvolvida em quatro fontes de dados eletrônicas. A extração, análise e síntese dos dados foi realizada por quatro pesquisadores independentes. Resultados: Nove publicações foram revisadas de 188 localizadas. Seis foram os países produtores das evidências, todas obtidas e publicadas em 2020. Vinte e um casos de COVID-19 no puerpério estiveram tratados nestas publicações, sendo 15 (71,4%) relativos a evoluções graves/exacerbação da doença e seis (28,6%) diagnosticados após a alta hospitalar. Conclusão: O mapeamento aponta para a ocorrência da infecção ou seu agravamento no período pós-parto, com indicativas ao monitoramento de sinais e sintomas, exploração diagnóstica e tratamento acurado e necessidade de acompanhamento próximo das mulheres diagnosticadas com COVID-19, sintomáticas ou não, no período pós-parto.


Objective: to map the evidence available in the literature about management and outcomes of postpartum infection by the new coronavirus. Method: scoping review conducted in four electronic sources, following Joanna Briggs Institute guidelines. Data were extracted, analyzed and summarized by four researchers independently. Results: nine of the 188 publications located were reviewed. The evidence, all obtained and published in 2020, was produced in six countries. These publications considered 21 cases of postpartum COVID-19, 15 (71.4%) of which related to severe developments / exacerbation of the disease and six (28.6%) diagnosed after hospital discharge. Conclusion: the mapping points to the occurrence of infection or worsening of the disease in the postpartum period, indicating the need for monitoring of signs and symptoms, diagnostic exploration and accurate treatment and the need for close monitoring of postpartum women diagnosed with COVID-19, whether symptomatic or not.


Objetivo: mapear las evidencias disponibles en la literatura sobre el manejo y los resultados de la infección por el nuevo coronavirus en el período posparto. Método: revisión del alcance según el Instituto Joanna Briggs, desarrollada en cuatro fuentes de datos electrónicas. La extracción, el análisis y la síntesis de los datos fueron realizados por cuatro investigadores independientes. Resultados: se revisaron nueve publicaciones de 188 encontradas. Fueron seis los países que produjeron las evidencias, obtenidas y publicadas en 2020. En estas publicaciones se trataron 21 casos de COVID-19 en el período posparto, 15 (71,4%) de los cuales estaban relacionados con evoluciones graves/exacerbación de la enfermedad y seis (28,6%) diagnosticados tras el alta hospitalaria. Conclusión: el mapeo apunta hacia la ocurrencia de la infección o su agravamiento en el posparto, con indicaciones de seguimiento de indicios y síntomas, exploración diagnóstica, tratamiento preciso y la necesidad de un seguimiento cercano a las mujeres diagnosticadas con COVID-19, sintomáticas o no, en el período posparto.


Subject(s)
Humans , Female , Pregnancy , Women's Health , Postpartum Period , COVID-19 , COVID-19/therapy , COVID-19/epidemiology , Review , Coronavirus Infections , Postpartum Period/blood , COVID-19/diagnosis
2.
Medisan ; 25(5)2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1346539

ABSTRACT

Introducción: La COVID - 19 es una enfermedad emergente, que ha afectado a todo el mundo de forma pandémica, con elevados costos sanitarios, económicos y sociales. Objetivo: Caracterizar a los pacientes extranjeros confirmados con la COVID - 19 en Santiago de Cuba, según variables clinicoepidemiológicas seleccionadas. Métodos: Se realizó un estudio observacional, descriptivo y transversal de 42 pacientes extranjeros, quienes visitaron la provincia de Santiago de Cuba y resultaron positivos a la COVID - 19, los cuales fueron remitidos a los centros de salud destinados para su atención desde marzo hasta diciembre del 2020. Se analizaron variables, tales como edad, sexo, municipio de residencia, país de procedencia, meses de mayor número de extranjeros que visitaron la provincia y evolución clínica. Resultados: El grupo etario de mayor frecuencia fue el de 30 - 44 años (14 pacientes para 33,3 %), seguido de los afectados de 45 - 59 (11 para 26,2 %). El municipio de Santiago de Cuba resultó el de mayor riesgo de incidencia (27 para 64,3 %). La manifestación clínica más común fue el malestar general y el país de procedencia que prevaleció, Estados Unidos (47,6 %). Todos los pacientes fueron importados. Conclusiones: Los integrantes de la casuística tuvieron una evolución favorable, lo cual permitió accionar, desde la atención primaria de salud, a fin de prevenir la enfermedad y realizar el control de foco como principal herramienta para cortar la cadena de transmisión.


Introduction: The COVID-19 is an emergent disease that has affected everybody in a pandemic way, with high sanitary, economic and social costs. Objective: To characterize foreign patients confirmed with the COVID-19 in Santiago de Cuba, according to selected clinical epidemiological variables. Methods: An observational, descriptive and cross-sectional study of 42 foreign patients who visited Santiago de Cuba province and tested positive to the COVID-19, who were referred to the health centers dedicated for their care was carried out from March to December, 2020. Some variables were analyzed, such as age, sex, residence municipality, origin country, months of more number of foreigners that visited the province and clinical course. Results: The age group of more frequency was that of 30 - 44 years (14 patients for 33.3 %), followed by those affected of 45 - 59 years (11 for 26.2 %). The municipality of Santiago de Cuba had the higher risk of incidence (27 for 64.3 %). The most common clinical sign was the diffuse discomfort and the origin country that prevailed, United States (47.6 %). All the patients were imported. Conclusions: The members of the case material had a favorable clinical course, that allowed to work, from the primary health care, in order to prevent the disease and to carry out the source of infection control as main tool to stop the transmission chain.


Subject(s)
Communicable Diseases, Emerging , COVID-19/diagnosis , COVID-19/epidemiology , Coronavirus
3.
Infectio ; 25(3): 169-175, jul.-set. 2021. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1250088

ABSTRACT

Resumen Objetivo: Verificación del desempeño de las pruebas serológicas rápidas utilizadas en el departamento de Risaralda, Colombia. Métodos: Estudio analitico, de corte transversal. Incluyó muestras de sueros de trabajadores de la salud de la ciudad de Pereira, quienes tuvieron sospecha clínica y epidemiológica por SARS-CoV-2. El procesamiento y validación de las pruebas fue realizado en las instalaciones de la Universidad Tecnológica de Pereira. Se calculó sensibilidad y especificidad de las pruebas rápidas serológicas IgM/IgG usando como prueba de oro la RT-PCR. Resultados: Se incluyeron las muestras de 144 profesionales de la salud. Las pruebas serológicas rápidas evidenciaron ser útiles para identificar o descartar la presencia de anticuerpos IgM e IgG, especialmente en pacientes sintomáticos, en quienes el inicio de los síntomas es superior a 11 días. Discusión: El uso de pruebas rápidas se encuentra en aumento, no solo por la rapidez de sus resultados, sino también por los bajos costos asociados y la necesidad de identificar pacientes no susceptibles, quienes deben priorizar su retorno a actividades laborales en comunidad como parte de la reactivación económica de Colombia. Es necesario confirmar el desempeño de la prueba para aumentar la probabilidad de una adecuada clasificación antes de proceder a su uso rutinario.


Abstract Objective: We aimed to realize a verification of the performance of the rapid serological tests used in Risaralda department. Methods: Analytical, cross-sectional study. Serum samples from health workers in Pereira city, who had a clinical and epidemiological suspicion for SARS-CoV-2 were included. The processing and validation of the tests was carried out at Universidad Tecnológica de Pereira. Sensitivity and specificity of rapid IgM / IgG sero logical tests were calculated using RT-PCR as the gold standard test. Results: 144 samples of health professionals were included. Rapid serological tests useful to identify or rule out the presence of IgM and IgG antibodies, especially in symptomatic patients, in whom the onset of symptoms is longer than 11 days. Discussion: The use of rapid tests is increasing, not only due to the speed of their results, but also due to the low associated costs and the need to identify non-susceptible patients, who must prioritize their return to work activities in the community as part of the economic reactivation of Colombia. It is necessary to confirm the adequate performance of the test to increase the probability of an adequate classification before proceeding with the routine use of this test.


Subject(s)
Humans , Male , Female , Adult , Serologic Tests , Health Personnel , SARS-CoV-2 , Cross-Sectional Studies , COVID-19/diagnosis , Antibodies , Occupational Groups , Antigens
4.
Rev. inf. cient ; 100(4): e3351, 2021.
Article in Spanish | LILACS | ID: biblio-1289661

ABSTRACT

RESUMEN Introducción: Se revelan limitaciones en la socialización de las consecuencias de la infección por coronavirus 2 causal de la enfermedad COVID-19 en la salud materna y perinatal. Objetivo: Recopilar información en relación con la influencia de la COVID-19 sobre el embarazo. Método: Entre enero y febrero de 2021, se efectuó una investigación en el Hospital General Docente "Dr. Agostinho Neto", Guantánamo, que consistió en una revisión narrativa. Se realizó el estudio documental de referencias, que incluyeron revisiones sistemáticas y artículos originales. La búsqueda se ejecutó en las bases de datos bibliográficas PubMed, Medline, Science Direct y SciELO, con el buscador Google Académico y el uso de las palabras clave y conectores COVID-19 AND embarazo; SARS-CoV-2 AND gestación y los correspondientes términos en español. Desarrollo: Se sintetizaron aspectos epidemiológicos, clínicos, inmunológicos e implicaciones clínicas de la enfermedad en pacientes embarazadas, pilares respecto al uso de medicamentos, para un abordaje de este tipo de paciente con COVID-19. Conclusiones: La gestante infectada por el SARS-CoV-2 es más vulnerable que el resto de la población, sin embargo, se requiere de investigaciones científicas que certifiquen su influencia real sobre la salud de la gestante y la perinatal, así como aquellos factores que modulan la enfermedad durante el embarazo.


ABSTRACT Introduction: Some limitations are revealed for socializing the consequences asociated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus that causes COVID-19, in maternal and perinatal health. Objective: To gathered information related to the influence of COVID-19 on pregnancy. Method: From January throughout February 2021, a narrative review was conducted for a research at the Hospital General Docente "Dr. Agostinho Neto" in Guantánamo. A documentary study of references was carried out, in which were included systematic reviews and original articles. Searches were conducted in the following bibliographic databases: PubMed, Medline, Science Direct and SciELO, via Google Scholar and using as keywords and linkers COVID-19 AND pregnancy, SARS-CoV-2 AND gestation and the correct terms in Spanish. Development: Epidemiological, clinical, immunological aspects and clinical implications of the disease in pregnant patients, pillars with respect to the use of drugs, were synthesized for an approach to this type of patient with COVID-19. Conclusions: Pregnant patients infected with SARS-CoV-2 are more vulnerable than the rest of the population, however, scientific research is required to certify its real influence on the health of pregnant and perinatal women, as well as those factors that modulate the disease during pregnancy.


RESUMO Introdução: Revelam-se limitações na socialização das consequências da infecção pelo coronavírus 2 causador da doença COVID-19 na saúde materna e perinatal. Objetivo: Coletar informações sobre a influência do COVID-19 na gravidez. Método: Entre janeiro e fevereiro de 2021, foi realizada investigação no Hospital General Docente "Dr. Agostinho Neto", Guantánamo, que consistiu numa revisão narrativa. Foi realizado o estudo documental das referências, que incluiu revisões sistemáticas e artigos originais. A busca foi realizada nas bases de dados bibliográficas PubMed, Medline, Science Direct e SciELO, com a ferramenta de busca Google Scholar e a utilização das palavras-chave e conectores COVID-19 AND pregn; SARS-CoV-2 AND gestation e os termos correspondentes em espanhol. Desenvolvimento: Aspectos epidemiológicos, clínicos, imunológicos e implicações clínicas da doença em gestantes, pilares quanto ao uso de medicamentos, foram sintetizados para uma abordagem desse tipo de paciente com COVID-19. Conclusões: A gestante infectada pelo SARS-CoV-2 é mais vulnerável que o restante da população, porém, pesquisas científicas são necessárias para atestar sua real influência na saúde da gestante e perinatal, bem como daqueles fatores que as mesmas modular a doença durante a gravidez.


Subject(s)
Humans , Female , Pregnancy , Pregnancy Complications, Infectious/epidemiology , COVID-19/complications , COVID-19/diagnosis , COVID-19/drug therapy , Pregnancy Complications, Infectious/etiology , Intensive Care Units
5.
Washington; OPS; 26 Ago. 2021. 25 p. (OPS/IMS/EIH/COVID-19/21-024).
Non-conventional in Spanish | LILACS | ID: biblio-1284283

ABSTRACT

Estas directrices de práctica clínica se elaboraron con el objetivo de proveer recomendaciones para el manejo de pacientes con COVID-19 leve y moderada, así como de personas en riesgo de infección por el SARS-COV-2 en América Latina y el Caribe. La población diana está constituida por personas en riesgo de infección por COVID-19, pacientes leves o moderados con sospecha diagnóstica o confirmada de COVID-19 Estas directrices de práctica clínica proveen recomendaciones basadas en la evidencia para la profilaxis de personas en riesgo de infección por el SARS-COV-2; para la identificación de marcadores y factores de riesgo de mortalidad de los pacientes con COVID-19 leve o moderado; el tamizaje de COVID-19; el manejo en el domicilio; el uso de imágenes diagnósticas para orientar el manejo; el tratamiento farmacológico; el uso de suplementos; la anticoagulación profiláctica, y los criterios de seguimiento y alta médica. Las recomendaciones se dirigen a todo el personal de salud que atiende a los pacientes en el servicio de urgencias y en atención primaria (médicos generales, especialistas en medicina de urgencias, en neumología, en medicina interna, en medicina familiar y en infectología, así como terapeutas respiratorios y físicos, personal de enfermería y químicos farmacéuticos, entre otros). Las recomendaciones se dirigen a tomadores de decisiones y miembros de entidades gubernamentales relacionados con el manejo de pacientes con COVID-19


Subject(s)
Humans , COVID-19/diagnosis , COVID-19/therapy , Severity of Illness Index , Triage , Caribbean Region , Latin America
6.
Arch. argent. pediatr ; 119(4): 224-229, agosto 2021. tab, ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1280889

ABSTRACT

Introducción. La apendicitis constituye la principal causa de abdomen agudo quirúrgico en pediatría. Durante la pandemia por COVID-19, se replantearon las estrategias de manejo ydisminuyeron las consultas en las guardias, lo que podría asociarse a diagnósticos tardíos y complicaciones. El objetivo de este estudio fue analizar el impacto de la pandemia en los niños con apendicitis aguda. Métodos. Estudio analítico retrospectivocomparativo de pacientes pediátricos conapendicitis aguda durante los cinco meses del confinamiento por COVID-19 versus los meses equivalentes del año previo. Se analizaron la incidencia, la clínica, el estadio, el abordajequirúrgico y las complicaciones. Resultados. Los casos totales de apendicitisse redujeron un 25 % (n = 67 versus n = 50 en 2020). El tiempo medio hasta la consulta fue de 24 horas en ambos períodos (p = 0,989). La incidencia de peritonitis fue del 44 % (n = 22) versus el 37 % (n = 22) (p = 0,22) en 2019. No se evidenció diferencia en los estadios deenfermedad de acuerdo con lo informado en los partes quirúrgicos. En 2019, todas las cirugías se realizaron por vía laparoscópica; en 2020, solo un42 % (n = 21). La incidencia de complicaciones fue del 6 %, contra 7,5 % en el período previo (p = 0,75). Un paciente fue COVID-19 positivo. Conclusión. A pesar de la reducción en el númerode casos de apendicitis, no se evidenció una demora en la consulta en nuestra población. El mayor impacto se asoció a la readecuación del manejo, evitando el abordaje laparoscópico para reducir la diseminación del virus.


Introduction. Appendicitis is the leading cause of surgical acute abdomen in pediatrics. During the COVID-19 pandemic, management strategies were reassessed and the number of visits to the emergency department dropped down, which may be associated with delayed diagnoses and complications. The objective of this study was to analyze the impact of the pandemic on children with acute appendicitis. Methods. Analytical, retrospective, comparative study of pediatric patients with acute appendicitis in the 5 months of COVID-19 lockdown versus the same period in the previous year. Incidence, clinical data, stage, surgical approach, and complications were analyzed. Results. The total number of appendicitis cases went down by 25 % (n = 67 versus n = 50 in 2020). The mean time to consultation was 24 hours in both periods (p = 0.989). The incidence of peritonitis was 44 % (n = 22) versus 37 % (n = 22) (p = 0.22) in 2019. No differences were  observed in terms of appendicitis stage based on surgery reports. In 2019, all surgeries were laparoscopic; while in 2020, only 42 % (n = 21). The incidence of complications was 6 % versus 7.5 % in the previous period (p = 0.75). One patient was COVID-19 positive. Conclusion. Although in our population the number of appendicitis cases dropped down, consultation was not delayed. The greater impact was associated with the reformulation of management strategies, in which the laparoscopic approach is avoided to reduce virus transmission.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Appendectomy/trends , Appendicitis/surgery , Appendicitis/diagnosis , Appendicitis/epidemiology , Practice Patterns, Physicians'/trends , Delayed Diagnosis/trends , COVID-19/prevention & control , Health Services Accessibility/trends , Appendectomy/methods , Argentina/epidemiology , Acute Disease , Incidence , Retrospective Studies , Laparoscopy/trends , Pandemics/prevention & control , Tertiary Care Centers , COVID-19/diagnosis , COVID-19/epidemiology , Hospitals, General
7.
Mem. Inst. Invest. Cienc. Salud (Impr.) ; 19(2)ago. 2021. tab, ilus
Article in Spanish | LILACS, BDNPAR | ID: biblio-1337822

ABSTRACT

Paraguay habilitó albergues sanitarios para que guarden cuarentena las personas venidas del exterior, como medida para evitar la propagación de casos de COVI-19. El objetivo fue describir las características epidemiológicas de los casos de COVID-19 diagnosticados en los albergues sanitarios en el Gran Asunción desde el 7 de marzo al 30 de setiembre. Estudio descriptivo, transversal, temporalmente retrospectivo. El muestreo fue no probabilístico de casos consecutivos. Las variables de los casos confirmados fueron, sexo, edad y distritos. Fueron utilizados datos de acceso abierto del Ministerio de Salud Pública y Bienestar Social. Para análisis estadístico de las variables fueron incluidas frecuencias, expresadas como porcentajes, para lo cual fue utilizado el programa Excel. Se diagnosticaron 390 casos en el Gran Asunción. El mayor número de casos se registró en agosto (118 casos). El 69,2% (270) de los casos en el Gran Asunción fue del sexo masculino, relación hombre/mujer de 2,3. El 34,9% (136) tenía edades entre 20 a 29 años, (promedio 33.8±16,14, IC95% 2,2- 65,5). El 80% (310) del total se presentó en menores de 50 años. Las ciudades con mayor cantidad de casos fueron Asunción (46,2%, 180) y los Distritos de Luque (8,7%, 34); Ñemby (6,4%, 25) y Capiatá (5,1%,20). Las características epidemiológicas presentadas son las esperadas, dado el perfil sociodemográfico de estas ciudades


Paraguay opened sanitary shelters to quarantine people arriving from abroad, as a measure to prevent the spread of COVID-19 cases. The objective was to describe the epidemiological characteristics of COVID-19 cases diagnosed in sanitary shelters in Greater Asunción from March 7 to September 30. It was a descriptive, cross-sectional, temporally retrospective study, with non - probabilistic sampling of consecutive cases. The variables of confirmed cases in quarantine facilities were sex, age and departments. Open access data from the Ministry of Public Health and Social Welfare were used. For statistical analysis of the variables, frequencies, expressed as percentages, were included and the Excel program was used for it. Three hundred and ninety cases were diagnosed in Greater Asunción. The highest number of cases was in August (118 cases), 69.2% (270) of the cases in Greater Asunción were male, with a male/female ratio of 2.3, 34.9% (136) ranged from 20 to 29 years old, (mean 33.8 ±16.14, 95% CI 2.2-65.5). Eighty percent (310) of the cases occurred in the population under 50 years of age. The locations that presented the highest number of cases were Asunción (46.2%, 180) and the Districts of Luque (8.7%, 34); Ñemby (6.4%, 25) and Capiatá (5.1%, 20). The epidemiological characteristics presented were expected given the socio demographic profile of these cities


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Public Health , COVID-19/diagnosis , COVID-19/epidemiology , Paraguay , Workhouses
8.
Arch. argent. pediatr ; 119(4): S198-S211, agosto 2021. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1281043

ABSTRACT

La pandemia ocasionada por el nuevo coronavirus (SARS-CoV-2), declarada por la Organización Mundial de la Salud OMS) en marzo de 2020, afecta a un reducido número de pacientes pediátricos, quienes presentan, en su mayoría, compromiso respiratorio leve y evolución favorable. Sin embargo, en niños previamente sanos, comenzó a observarse un aumento de casos definidos como síndrome inflamatorio multisistémico (SIM-C) o similar a Kawasaki (Kawasaki-like) asociado a la enfermedad por el nuevo coronavirus (COVID-19) (KL-C) que evolucionan al shock y requieren internación en la unidad de cuidados intensivos.Los cuadros de SIM-C y los KL-C se caracterizan por fiebre, signos de inflamación, síntomas gastrointestinales y disfunción cardiovascular; las formas graves de presentación tienen mayor incidencia de hipotensión y/o shock. En el laboratorio se observan marcadores de inflamación, hipercoagulabilidad y daño miocárdico. El tratamiento farmacológico de primera línea consiste en la administración de inmunoglobulina por vía intravenosa más ácido acetilsalicílico por vía oral.Se recomienda un abordaje multidisciplinario para un diagnóstico certero y un tratamiento temprano y eficaz para disminuir la morbimortalidad.


The pandemic caused by the SARS-CoV-2 virus declared by the WHO in March 11th 2020, affects a small number of pediatric patients, who mostly present mild respiratory compromise and favorable evolution.However began to be observed in previously healthy children, an increase in cases defined as "Multisystemic Inflammatory Syndrome" (MIS-C) or "Kawasaki-like" post-COVID 19 (KL-C) that evolve to shock and require hospitalization in the Pediatric Intensive Care Unit.MIS-C and KL-C are characterized by fever; signs of inflammation, gastrointestinal symptoms, and cardiovascular dysfunction, associated with sever forms of presentation with higher incidence of hypotension and/or shock. In the laboratory, markers of inflammation, hypercoagulability and myocardial damage are observed. First-line drug treatment consists of intravenous immunoglobulin plus oral acetylsalicylic acid.A multidisciplinary approach is recommended for an accurate diagnosis and an early and effective treatment, in order to reduce morbidity and mortality.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Systemic Inflammatory Response Syndrome/therapy , COVID-19/therapy , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Aspirin/therapeutic use , Immunoglobulins, Intravenous/therapeutic use , Systemic Inflammatory Response Syndrome/complications , Systemic Inflammatory Response Syndrome/diagnosis , Critical Care , Diagnosis, Differential , COVID-19/complications , COVID-19/diagnosis , Mucocutaneous Lymph Node Syndrome/complications , Mucocutaneous Lymph Node Syndrome/diagnosis , Mucocutaneous Lymph Node Syndrome/therapy
9.
Rev. inf. cient ; 100(3): e3483, 2021. tab
Article in Spanish | LILACS | ID: biblio-1289644

ABSTRACT

RESUMEN Introducción: A finales de enero de 2020, la Organización Mundial de la Salud declaró el brote de la enfermedad por el nuevo coronavirus (COVID-19) como una emergencia de Salud Pública de importancia internacional y la reconoció, además, como pandemia el 11 de marzo de ese mismo año. Objetivo: Caracterizar clínica y epidemiológicamente a pacientes con COVID-19. Método: Estudio descriptivo y retrospectivo sobre las características clínicas y epidemiológicas de los 492 pacientes diagnosticados con COVID-19 en el Policlínico Universitario "Emilio Daudinot Bueno", de Guantánamo. Se estudiaron las siguientes variables: grupos de edad, sexo, consejo popular, fuente de infección, presencia o no de síntomas y signos, como fueron: fiebre, tos, disnea, malestar general, dolor de garganta, cefalea, congestión nasal, anosmia y dolor lumbar. La información fue obtenida de la Vicedirección de Higiene y Epidemiología del propio policlínico, procesada en Excel. Resultados: Hubo discreto predominio del sexo femenino, predominaron mayores de 60 años (22,35 %), el consejo popular de Pastorita con mayor número de casos para un 60,16 %. Predominó en relación a la fuente de infección, la trasmisión en la comunidad (74,59 %). Entre los pacientes com sintomatologia predominó la fiebre como manifestación clínica importante (20,93 %). Conclusiones: Conocer y comprender las características clínico-epidemiológicas que se asocian a la COVID-19 es de suma importancia para una adecuada implementación de los planes establecidos para el control de la enfermedad en la Atención Primaria de Salud con la participación activa de los consejos de defensa y la comunidad.


ABSTRACT Introduction: Ending January 2020, the World Health Oganization declared the outbrake of the new coronavirus, labeled (COVID-19), as a worldwide public health emergency and in March 11, on the same year, was declared as pandemic. Objective: To characterize the clinical and epidemiologic features in patients with COVID-19. Method: a descriptive and retrospective study concerning clinical and epidemiologic features of 492 patients diagnosed with COVID-19 at the Policlínico Universitario "Emilio Daudinot Bueno", in Guantánamo, was carried out. Variables studied were as follow: age groups, sex, district area, source of infection, presence or absence of signs and symptoms (fever, cough, dyspnea, general malaise, sore throat, headache, nasal congestion, anosmia and low back pain. Results: There was a slight female predominance, with a predominance in patients older than 60 years old (22.35%), Pastorita district was reported with the highest number of cases (60.16%). Transmission of infection in the community was the predominance source of infection (74.59%). Fever was the most important clinical manifestation found among patients with symptoms (20.93%). Conclusions: Get to know and understanding the clinical and epidemiologic features associated with COVID-19 are very important for the adequate implementation of the established protocols performed to control the disease in the primary health care, involving aggressively in this process, the community and the government institutions.


RESUMO Introdução: No final de janeiro de 2020, a Organização Mundial da Saúde declarou o surto da nova doença coronavírus (COVID-19) como uma emergência de Saúde Pública de importância internacional e também o reconheceu como uma pandemia em 11 de março do mesmo ano. Objetivo: Caracterizar clínica e epidemiologicamente os pacientes com COVID-19. Método: Estudo descritivo e retrospectivo das características clínicas e epidemiológicas de 492 pacientes com diagnóstico de COVID-19 na Policlínica Universitária "Emilio Daudinot Bueno", em Guantánamo. Se estudiaron las siguientes variables: grupos de edad, sexo, consejo popular, fuente de infección, presencia o no de síntomas y signos, como fueron: fiebre, tos, disnea, malestar general, dolor de garganta, cefalea, congestión nasal, anosmia y dor lombar. Resultados: Houve ligeiro predomínio do sexo feminino, com predomínio dos maiores de 60 anos (22,35%), o conselho popular de Pastorita com maior número de casos para 60,16%. A transmissão na comunidade predominou em relação à fonte de infecção (74,59%). Entre os pacientes com sintomas, a febre predominou como manifestação clínica importante (20,93%). Conclusões: Conhecer e compreender as características clínico-epidemiológicas associadas ao COVID-19 é de extrema importância para uma adequada implementação dos planos estabelecidos para o controle da doença na Atenção Básica à Saúde com a participação ativa dos conselhos de advocacia e comunidade.


Subject(s)
Humans , Adult , Middle Aged , Health Programs and Plans/organization & administration , COVID-19/diagnosis , COVID-19/transmission , COVID-19/epidemiology , Primary Health Care , Epidemiology, Descriptive , Retrospective Studies
10.
Rev. bras. anal. clin ; 53(2): 148-154, 20210630. graf, tab
Article in Portuguese | LILACS | ID: biblio-1349032

ABSTRACT

Objetivo: Analisar as alterações de exames laboratoriais de gestantes e puérperas com diagnóstico laboratorial de COVID-19 atendidas em uma maternidade de referência em Fortaleza/Ceará, no período de março a outubro de 2020. Métodos: Trata-se de um estudo retrospectivo, descritivo, com abordagem quantitativa, envolvendo análise de dados dos exames laboratoriais de pacientes com diagnóstico confirmatório para COVID-19 no período de março a outubro de 2020. Os dados foram coletados a partir dos resultados de exames obtidos nas plataformas institucionais, revisão de dados e evoluções do prontuário físico e eletrônico. Resultados: As pacientes apresentaram notória redução de hemoglobina e hematócrito, leucocitose com linfopenia e alteração de parâmetros bioquímicos de função hepática. Na amostra estudada, obteve-se um percentual de óbitos de 5%. Além disso, evidenciou-se alteração de marcadores de inflamação e coagulação, dados que corroboram com os estudos na área. Conclusão: As alterações específicas da COVID-19 foram detectadas nos dois grupos de pacientes, ressaltando-se a importância da realização de novos estudos com enfoque na população gestante e puérpera, pois as consequências da doença nessa população podem afetar diretamente o binômio mãe-bebê.


Objective: To analyze the changes in laboratory tests of pregnant women and postpartum women with a laboratory diagnosis of COVID-19 attended at a reference maternity hospital in Fortaleza / Ceará, from March to October 2020. Methods: This is a retrospective, descriptive study, with a quantitative approach, involving the analysis of data from laboratory tests of patients with a confirmatory diagnosis for COVID-19 in the period from March to October 2020. The data were collected from the results of tests obtained in the institutional platforms as well as data review and evolution physical and electronic medical records. Results: The patients showed a marked reduction in hemoglobin and hematocrit, leukocytosis with lymphopenia and alteration of biochemical parameters of liver function. In the sample studied, a percentage of deaths of 5% was obtained. In addition, changes in inflammation and coagulation markers were evidenced, data that corroborate with studies in the area. Conclusion: Specific changes in COVID-19 were detected in the two groups of patients, emphasizing the importance of conducting further studies focusing on the pregnant and postpartum population, as the consequences of the disease in this population can be applied directly in the mother-child binomial.


Subject(s)
Humans , Female , Pregnancy , Coronavirus , Pregnant Women , Laboratory Test , COVID-19/diagnosis
11.
Rev. bras. anal. clin ; 53(2): 155-162, 20210630. ilus, tab
Article in Portuguese | LILACS | ID: biblio-1349033

ABSTRACT

A rápida caracterização do genoma do Coronavírus-2 (SARS-CoV-2) mobilizou a produção em larga escala de métodos diagnósticos. Agências reguladoras aprovaram condicionalmente o uso emergencial de vários deles. Na emergência de saúde, inúmeros exames foram utilizados sem o devido conhecimento da qualidade. O objetivo desta revisão narrativa foi destacar a acurácia diagnóstica dos métodos sorológicos de diagnóstico da COVID-19 em termos de sensibilidade e especificidade clínicas. A sensibilidade diagnóstica variou até 50% entre estudos, enquanto a especificidade apresentou menor variação; no entanto, uma mesma marca chegou a apresentar variação de 32%. Considerando-se o critério de especificidade >95% definido pelo FDA, apenas uma marca de ensaio para detecção de IgG e outra para IgM atingiram a meta. Para a detecção de IgA e de IgA+IgM, as únicas marcas apresentadas não atingiram a meta. Entre as cinco marcas para detecção de IgM+IgG, apenas uma não atingiu a especificidade clínica. Para Ig total, as duas marcas apresentaram especificidade aceitável. Considerando-se o critério de sensibilidade clínica >90%, apenas 6 dos 25 estudos com diferentes marcas de ensaios para detecção de IgG apresentam o desempenho especificado; destas, nenhuma é brasileira. Nenhuma das marcas de ensaios para detecção de IgM e IgM+IgG apresentaram o desempenho especificado. A única marca apresentada para detecção de IgA+IgM atingiu a meta especificada pelo FDA. Os ensaios imunocromatográficos apresentaram menor sensibilidade. Os resultados demonstraram o pobre valor diagnóstico dos imunoensaios, mas com potencial para estudos soroepidemiológicos. Mais estudos de validação analítica e acurácia diagnóstica de ensaios são essenciais, principalmente dos reagentes nacionais.


The rapid characterization of the coronavirus-2 (SARS-CoV-2) genome has mobilized the large-scale production of diagnostic methods. Regulatory agencies have conditionally approved the emergency use of several of them. In the health emergency, numerous tests were used without proper knowledge of quality. The aim of this narrative review was to highlight the diagnostic accuracy of serological methods for the diagnosis of COVID-19 in terms of clinical sensitivity and specificity. The diagnostic sensitivity varied up to 50% between studies, while the specificity showed less variation, however, the same brand even showed a variation of 32%. Considering the >95% specificity criteria defined by the FDA, only one test brand for detection of IgG and one for IgM reached the goal. For the detection of IgA and IgA+IgM, the only brands presented did not reach the goal. Among the 5 marks for detecting IgM+IgG, only one did not reach clinical specificity. For total Ig, both brands had acceptable specificity. Considering the criterion of clinical sensitivity >90%, only 6 of the 25 studies with different brands of assays for detection of IgG present the specified performance, none of which are Brazilian. None of the brands of assays for detecting IgM and IgM+IgG showed the specified performance. The only brand presented for detection of IgA+IgM reached the target specified by the FDA. Immunochromatographic assays showed lower sensitivity. The results demonstrated the poor diagnostic value of immunoassays, but with potential for seroepidemiological studies. More studies on analytical validation and diagnostic accuracy of assays are essential, especially for national reagents.


Subject(s)
Immunoglobulin G , Immunoglobulin M , Serologic Tests , Data Accuracy , SARS-CoV-2 , COVID-19/diagnosis
12.
Nursing (Säo Paulo) ; 24(277): 5785-5792, jun.2021.
Article in Portuguese | LILACS, BDENF | ID: biblio-1253547

ABSTRACT

Objective: To describe the difficulties reported by health professionals during the screening service, given the difficulties in assisting suspected or confirmed patients at COVID-19. Method: This is an experience report of the care provided in nursing screening to health professionals to collect samples for the diagnosis of COVID-19, between April and July 2020, at a public university in central Brazil. Results: The difficulties reported were: limited access to Personal Protective Equipment in the workplace; restricted access to diagnostic testing for COVID-19 and poor knowledge about the differentiation and purpose of the tests. Conclusion: The performance of nursing to health professionals in the pandemic is extremely important. Strategic approaches by government agencies and health institutions regarding training for health professionals and access to equipment necessary for workers' health are relevant.(AU)


Objetivo: Describir las dificultades reportadas por los profesionales de la salud durante el servicio de cribado, dadas las dificultades para atender a pacientes sospechosos o confirmados en COVID-19. Método: Se trata de un informe de experiencia de la atención brindada en el cribado de enfermería a profesionales de la salud para recolectar muestras para el diagnóstico de COVID-19, entre abril y julio de 2020, en una universidad pública del centro de Brasil. Resultados: Las dificultades reportadas fueron: acceso limitado a Equipo de Protección Personal en el lugar de trabajo; acceso restringido a las pruebas de diagnóstico para COVID-19 y poco conocimiento sobre la diferenciación y el propósito de las pruebas. Conclusión: El desempeño de la enfermería a los profesionales de la salud en la pandemia es de suma importancia. Los enfoques estratégicos de las agencias gubernamentales y las instituciones de salud con respecto a la capacitación de los profesionales de la salud y el acceso a los equipos necesarios para la salud de los trabajadores son relevantes.(AU)


Objetivo: Descrever as dificuldades relatadas pelos profissionais de saúde perante a assistência a pacientes suspeitos ou confirmados da COVID-19, durante um atendimento em triagem para realização de exame. Método: Trata-se de um relato de experiência dos atendimentos em triagem de enfermagem à profissionais de saúde para coleta de amostras para o diagnóstico da COVID-19, entre abril a julho de 2020, em uma universidade pública da região central do Brasil. Resultados: As dificuldades reportadas foram: acesso limitado aos Equipamentos de Proteção Individual nos ambientes de trabalho; acesso restrito a testagem diagnóstica para COVID-19 e pouco conhecimento sobre a diferenciação e finalidade dos testes. Conclusão: A atuação da enfermagem aos profissionais da saúde na pandemia é de extrema importância. É relevante abordagens estratégicas de órgãos governamentais e de instituições de saúde acerca de capacitação para os profissionais da saúde e acesso aos equipamentos necessários para a saúde do trabalhador.(AU)


Subject(s)
Humans , Triage , Health Personnel , COVID-19/diagnosis , Public Health Nursing , Mass Screening , Diagnosis
15.
Goiânia; SES-GO; 15; 21 maio 2021. 1-52 p. ilus, tab.
Non-conventional in Portuguese | LILACS, ColecionaSUS, CONASS, SES-GO | ID: biblio-1096093

ABSTRACT

O surto da doença respiratória causada pelo novo coronavírus (SARS-CoV-2) aconteceu na cidade de Wuhan, capital da província de Hubei, na China, em dezembro de 2019, a qual disseminou-se de forma acelerada e, logo, atingiu mais de uma centena de países dos cinco continentes. Em 12 de março de 2020, a situação foi caracterizada como pandemia pela Organização Mundial de Saúde (OMS, 2020). Em razão da disseminação o do Coronavírus pelo mundo, o Ministério da Saúde declarou Emergência de Saúde Pública de Importância Nacional (ESPIN) em decorrência da infecção pelo novo coronavírus (COVID-19) e estabeleceu o Centro de Operações de Emergência em Saúde Pública (COE-COVID-19) como mecanismo de gestão coordenada da resposta à ESPIN no país (BRASIL, 2020a). Seguindo a linha mundial, o Ministério da Saúde elaborou e publicou "Plano de Contingência Nacional para Infecção Humana pelo Novo Coronavírus COVID-19" para organizar a detecção, monitoramento e resposta dos serviços de saúde à doença (BRASIL, 2020b). O Estado de Goiás instituiu o Centro de Operações Estratégicas de Saúde Pública (COE) em 18 de fevereiro de 2020 (GOIÁS, 2020a). E, seguindo as orientações nacionais, propõe o presente PLANO ESTADUAL DE CONTINGÊNCIA PARA O ENFRENTAMENTO DA DOENÇA PELO CORONAVÍRUS (COVID-19), a fim de organizar e fortalecer as políticas públicas de saúde, visto que, para que atinjam eficácia e eficiência, é necessário atuação conjunta e ordenada dos entes federados, bem como dos setores públicos e privados.


The outbreak of respiratory disease caused by the new coronavirus (SARS-CoV-2) occurred in Wuhan city, capital of Hubei province, China, in December 2019, which spread rapidly and thus reached more than a hundred countries on five continents. On March 12, 2020, the situation was characterized as a pandemic by the World Health Organization (WHO, 2020). Due to the spread of Coronavirus around the world, the Ministry of Health declared a Public Health Emergency of National Importance (ESPIN) due to infection by the new coronavirus (COVID-19) and established the Center for Emergency Operations in Public Health (COE-COVID-19) as a mechanism for coordinated management of the response to ESPIN in the country (BRASIL, 2020a). Following the global line, the Ministry of Health elaborated and published "National Contingency Plan for Human Infection by the New Coronavirus COVID-19" to organize the detection, monitoring and response of health services to the disease (BRASIL, 2020b). The State of Goiás established the Center for Strategic Operations of Public Health (COE) on February 18, 2020 (GOIÁS, 2020a). And, following the national guidelines, it proposes this State CONTINGENCY PLAN FOR COPING WITH CORONAVIRUS DISEASE (COVID-19), in order to organize and strengthen public health policies, since, in order to achieve effectiveness and efficiency, joint and orderly action of federal entities, as well as public and private sectors, is necessary.


Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , COVID-19/complications , COVID-19/diagnosis , COVID-19/prevention & control , COVID-19/transmission , Pandemics
16.
Rev. cuba. med. trop ; 73(1): e603, tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1280332

ABSTRACT

. Introducción: Con los primeros casos de COVID-19 en Cuba era necesario el reconocimiento temprano de los pacientes con riesgo de evolucionar hacia formas graves de la enfermedad. Objetivo: Describir el comportamiento clínico de la COVID-19 en pacientes hospitalizados en el Instituto de Medicina Tropical "Pedro Kourí" e identificar factores asociados a la gravedad. Métodos: Se presentaron los primeros 73 casos de COVID-19 hospitalizados en el Instituto de Medicina Tropical Pedro Kourí desde el 11 de marzo al 5 mayo de 2020. Los pacientes se clasificaron en dos grupos: graves y con enfermedad ligera. Se compararon variables clínicas, demográficas, de laboratorio e imagenológicas en el momento del ingreso, y su posible asociación con la gravedad de la enfermedad. Resultados: Hubo siete pacientes graves (9,6 por ciento), cinco fallecieron. La edad > 60 años, tener más de una comorbilidad, hipertensión arterial y asma bronquial, fueron más frecuentes en pacientes graves. La fiebre más de seis días (p= 0,00), disnea (p= 0,00), presencia de estertores húmedos (p= 0,00), frecuencia respiratoria > 24/min (p= 0,00) y valores de linfocitos < 0,8 x109/L (p= 0,00), de ferritina > 500µg/L (p =0,00), proteína C reactiva ( 10μg/L (p= 0,01) y LDH ( 500 U/L (p= 0,01) se relacionaron con la gravedad. El 18,2 por ciento de las radiografías de tórax mostró alteraciones, con predominio de focos de condensación inflamatoria bilateral. Las complicaciones más frecuentes fueron: distrés respiratorio, choque, sepsis bacteriana y afecciones cardíacas. Conclusiones: Existen características clínicas y de laboratorio, identificables al ingreso, que están relacionadas con la gravedad de la enfermedad; lo que puede ser útil para la estratificación del riesgo y el manejo adecuado de los pacientes(AU)


Introduction: Upon appearance of the first COVID-19 cases in Cuba, early identification of patients at risk of developing severe forms of the disease became a necessity. Objective: Describe the clinical behavior of COVID-19 in patients admitted to Pedro Kourí Tropical Medicine Institute and identify factors associated to severity. Methods: A presentation was made of the first 73 COVID-19 cases admitted to Pedro Kourí Tropical Medicine Institute from 11 March to 5 May 2020. The patients were divided into two groups: severe and mild disease. A comparison was made of clinical, demographic, laboratory and imaging variables at admission, and their possible association to disease severity. Results: Seven patients (9.6%) were critically ill; five died. Age > 60 years, more than one comorbidity, arterial hypertension and bronchial asthma were more common among critical patients. Fever for more than six days (p= 0.00), dyspnea (p= 0.00), presence of humid stertors (p= 0.00), respiratory rate > 24/min (p= 0.00) and lymphocytes < 0.8 x109/l (p= 0.00), ferritin > 500 µg/L (p =0.00), C-reactive protein 10 μg/l (p= 0.01) and LDH 500 U/l (p= 0.01) were related to disease severity. 18.2 percent of the chest radiographs showed alterations, with a predominance of bilateral foci of inflammatory condensation. The most common complications were respiratory distress, shock, bacterial sepsis and heart disorders. Conclusions: Some clinical and laboratory characteristics identifiable at admission may be associated to disease severity, which makes them useful for risk stratification and the appropriate management of patients(AU)


Subject(s)
Humans , Clinical Laboratory Techniques/methods , COVID-19/complications , COVID-19/diagnosis , COVID-19/drug therapy , Cuba , Laboratory Critical Values
17.
Säo Paulo med. j ; 139(2): 190-195, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1181008

ABSTRACT

ABSTRACT BACKGROUND: Although it is known that the new coronavirus disease (COVID-19), which was first seen in Wuhan, China, in December 2019 and has affected the whole world, mainly targets the respiratory tract, cases of this disease with a wide clinical spectrum are emerging as information is shared. CASE REPORT: We present the case of a pregnant woman who was diagnosed with venous sinus thrombosis after she developed headache and hemiparesis. Polymerase chain reaction (PCR) positivity lasted for two weeks after COVID-19 had been diagnosed. CONCLUSIONS: In patients with suspected COVID-19, especially in the presence of causes of hypercoagu- lability and presence of atypical features, venous sinus thrombosis needs to be kept in mind in making the differential diagnosis.


Subject(s)
Humans , Female , Pregnancy , Venous Thrombosis/diagnosis , SARS-CoV-2/isolation & purification , SARS-CoV-2/genetics , COVID-19/complications , Headache/etiology , Paresis/etiology , Sinus Thrombosis, Intracranial/diagnostic imaging , China , Polymerase Chain Reaction , Thrombophilia , COVID-19 Testing , COVID-19/diagnosis
18.
Säo Paulo med. j ; 139(2): 170-177, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1181006

ABSTRACT

ABSTRACT BACKGROUND: Healthcare institutions are confronted with large numbers of patient admissions during large-scale or long-term public health emergencies like pandemics. Appropriate and effective triage is needed for effective resource use. OBJECTIVES: To evaluate the effectiveness of the Pandemic Medical Early Warning Score (PMEWS), Simple Triage Scoring System (STSS) and Confusion, Uremia, Respiratory rate, Blood pressure and age ≥ 65 years (CURB-65) score in an emergency department (ED) triage setting. DESIGN AND SETTING: Retrospective study in the ED of a tertiary-care university hospital in Düzce, Turkey. METHODS: PMEWS, STSS and CURB-65 scores of patients diagnosed with COVID-19 pneumonia were calculated. Thirty-day mortality, intensive care unit (ICU) admission, mechanical ventilation (MV) need and outcomes were recorded. The predictive accuracy of the scores was assessed using receiver operating characteristic curve analysis. RESULTS: One hundred patients with COVID-19 pneumonia were included. The 30-day mortality was 6%. PMEWS, STSS and CURB-65 showed high performance for predicting 30-day mortality (area under the curve: 0.968, 0.962 and 0.942, respectively). Age > 65 years, respiratory rate > 20/minute, oxygen saturation (SpO2) < 90% and ED length of stay > 4 hours showed associations with 30-day mortality (P < 0.05). CONCLUSIONS: CURB-65, STSS and PMEWS scores are useful for predicting mortality, ICU admission and MV need among patients diagnosed with COVID-19 pneumonia. Advanced age, increased respiratory rate, low SpO2 and prolonged ED length of stay may increase mortality. Further studies are needed for developing the triage scoring systems, to ensure effective long-term use of healthcare service capacity during pandemics.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Pneumonia/diagnosis , Pneumonia/epidemiology , Triage/methods , Risk Assessment/methods , Emergency Service, Hospital/statistics & numerical data , Early Warning Score , COVID-19/therapy , Turkey , Uremia/etiology , Uremia/epidemiology , Blood Pressure , Retrospective Studies , Respiratory Rate/physiology , Pandemics , SARS-CoV-2 , COVID-19/diagnosis , COVID-19/epidemiology
19.
Actual. SIDA. infectol ; 29(105): 42-48, 2021 mar. tab
Article in Spanish | LILACS, BINACIS | ID: biblio-1348946

ABSTRACT

Introducción: La pandemia de COVID-19 representa un desafío para la salud mundial y continúa en investigación. Objetivo: Describir las características epidemiológicas, demográficas, clínicas y la mortalidad por todas las causas de pacientes internados con COVID-19 en un establecimiento de salud privado de la Ciudad de Buenos Aires. Materiales y métodos: Se realizó un estudio retrospectivo, de corte transversal y descriptivo entre el 3 de marzo y el 8 de julio de 2020. Se incluyeron pacientes adultos con diagnóstico confirmado de COVID-19 por RT-PCR de hisopado nasofaríngeo internados en sala general y unidad de terapia intensiva (UTI) del Sanatorio San José. Se analizaron las características epidemiológicas, demográficas (edad, sexo, ocupación, procedencia, residencia), clínicas y mortalidad por todas las causas. Las variables continuas fueron descriptas con mediana y rango intercuartilo (RIC) y las variables categóricas con número y porcentaje. Se utilizó el programa STATA v 13.0.Resultados: Se incluyeron 118 pacientes. La mediana de edad fue de 50 años, 51% varones. Las comorbilidades más prevalentes fueron hipertensión arterial 31,4%, enfermedad neurológica crónica 27,1%, enfermedad cardiovascular 14,4% y diabetes 13,6%. Los signos y síntomas más frecuentes: fiebre 68,6% y tos 51,7%. Según la severidad inicial: 33,9% neumonía moderada y 27,1% grave. El 75% de las tomografías de tórax reveló vidrio esmerilado; linfopenia presentó el 30%. No se detectó coinfección viral. La mortalidad por todas las causas fue del 20%, y del 57% en UTI con ventilación mecánica. Conclusiones: Nuestro trabajo describe las características y mortalidad de pacientes internados con COVID-19. Es necesario aumentar la evidencia para desarrollar modelos de predicción clínica relacionados con COVID-19.Palabras clave: infecciones por coronavirus, pandemias, epidemiología, COVID-19.


ntroduction: The COVID-19 pandemic represents a global health challenge and continues to be investigated.Objective: To describe the epidemiological, demographic, clinical characteristics and all-cause mortality of patients hospitalized with COVID-19, in a private health care facility in Buenos Aires city.Materials and methods: A retrospective, cross-sectional, and descriptive study was conducted between March 3 and July 8, 2020. Adult patients with a confirmed diagnosis of COVID-19 by nasopharyngeal swab RT-PCR, admitted to the general ward and intensive care unit (ICU) at the San José Sanatorium were included. Epidemiological, demographic (age, sex, occupation, origin, residence), clinical characteristics, and all-cause mortality were analyzed. Continuous variables were described with median and interquartile range (IQR) and categorical variables with number and percentage. The STATA v 13.0 program was used. Results: 118 patients were included. The median age was 50 years, 51% were men. The most prevalent comorbidities: arterial hypertension 31.4%, chronic neurological disease 27.1%, cardiovascular disease 14.4% and diabetes 13.6%. The most frequent signs and symptoms: fever 68.6% and cough 51.7%. According to the initial severity: 33.9% moderate pneumonia and 27.1% severe. Ground glass was reported in 75% of chest scans; lymphopenia presented 30%. Viral coinfection was not detected. Mortality from all causes was 20%, and 57% in ICU with mechanical ventilation.Conclusions: Our work describes the characteristics and mortality of hospitalized patients with COVID-19. Increased evidence is needed to develop clinical predictive models related to COVID-19


Subject(s)
Humans , Health Profile , Medical Records , Epidemiology, Descriptive , Cross-Sectional Studies/statistics & numerical data , Retrospective Studies , COVID-19/diagnosis , COVID-19/mortality , COVID-19/therapy
20.
ABCS health sci ; 46: e021302, 09 fev. 2021. tab, ilus
Article in English | LILACS | ID: biblio-1281240

ABSTRACT

INTRODUCTION: The spread of SARS-CoV-2 has caused a global public health crisis (pandemic). One of the most important measures to control the transmission chain of the new coronavirus is to identify those infected through laboratory testing. OBJECTIVE: Synthesize the recommendations for the specimen collection for detection and diagnosis of COVID-19. METHODS: This is an integrative review, considering the publications of the following databases: PubMed and Google Academic from January 2020. RESULTS: 468 publications were identified, 20 of which were considered eligible. The publications recommend that technical training for specimen collection and careful observation of infection prevention protocols are fundamental. This manuscript highlights the steps for specimen collection as materials for collection, storage, transportation, individual protection, and laboratory analysis of samples. Currently, the Reverse Transcription - Polymerase Chain Reaction test is the recommended and gold standard method of identifying COVID-19 cases. Serological tests play an important role in research and surveillance. CONCLUSION: In summary, the documents ensure that the RT-PCR is the gold standard for SARS-CoV-2 detection and recommend standardization of collection and conditioning methods to avoid errors related to the collection and false negative results.


INTRODUÇÃO: A disseminação do SARS-CoV-2 ocasionou uma crise na saúde pública mundial (pandemia). Uma das mais importantes medidas de controle da cadeia de transmissão do novo coronavírus consiste em identificar os infectados por meio de teste laboratorial. OBJETIVO: Sintetizar as recomendações para a coleta de amostras para detecção e diagnóstico da COVID-19. MÉTODO: Trata-se de uma revisão integrativa, considerando as publicações do Google Acadêmico e Pubmed a partir de janeiro de 2020. RESULTADOS: Foram identificadas 468 publicações, das quais 20 foram consideradas elegíveis. As publicações recomendam que a capacitação técnica para a coleta das amostras e a observação criteriosa de protocolos de prevenção de infecção são fundamentais. Destacam-se nesse artigo as etapas para a coleta de amostras como materiais para coleta, armazenamento, transporte, proteção individual e análise laboratorial das amostras. Atualmente, o teste de Reverse Transcription - Polymerase Chain Reaction é o método recomendado e padrão-ouro para a identificação dos casos de COVID-19. Os testes sorológicos desempenham um papel importante na pesquisa e vigilância. CONCLUSÃO: Em síntese, os documentos asseguram que o RT-PCR é o teste padrão-ouro para detecção do SARS-CoV-2 e recomenda a padronização dos métodos de coleta e acondicionamento, a fim de evitar erros relacionados com a coleta e resultados falso-negativos.


Subject(s)
Specimen Handling , COVID-19 Testing , COVID-19/diagnosis , Pandemics
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