Factors associated with oropharyngeal dysphagia in individuals with cardiovascular disease and COVID-19

PURPOSE: Oropharyngeal dysphagia (OD) is one of the possible outcomes in patients hospitalized with COVID-19 and also in the population hospitalized for the treatment of cardiovascular disease. Thus, knowing the predictive risk factors for OD may help with referral and early intervention. This study aimed to verify the association of different factors with OD in hospitalized individuals with cardiovascular disease and COVID-19. METHODS: Cross-sectional clinical study approved by the Research Ethics Committee (4,521,771). Clinical evaluation of swallowing was carried out in 72 adult patients with cardiovascular disease and COVID-19 hospitalized from April to September 2020. Individuals under 18 years of age and without previous cardiovascular disease were excluded. The presence of general clinical and/or neurological complications, pronation, stay in the intensive care unit (ICU), orotracheal intubation (OTI), tracheostomy tube, oxygen support and age were considered as predictive risk factors for oropharyngeal dysphagia. Fisher's exact test, Mann Whitney test and logistic regression model were used for analysis. RESULTS: General clinical complications (p=0.001), pronation (p=0.003), ICU stay (p=0.043), in addition to the need for oxygen supplementation (p=0.023) and age (p= 0 .037) were statistically significant factors associated. The pronation (0.013) and age (0.038) were independently associated with dysphagia. OTI (p=0.208), tracheostomy (p=0.707) and the presence of previous cerebrovascular accidents (p=0.493) were not statistically significant. CONCLUSION: In this study, age and prone position were factors independently associated with oropharyngeal dysphagia, complications such as the need for oxygen supplementation, in addition to the need for ICU admission, were also associated factors in the population.

Asociación de la salud cardiometabólica de preescolares y sus padres con características nutricionales y sociodemográficas familiares / Association of cardiometabolic health of preschoolers and their parents with family sociodemographic characteristics

Introducción: Existe escaso conocimiento sobre la asociación entre marcadores cardiometabólicos en preescolares con características nutricionales y sociodemográficos familiares. Objetivo: Determinar la asociación entre marcadores cardiometabólicos de preescolares y sus padres con las características nutricionales y sociodemográficas familiares. Materiales y Métodos: Estudio de corte transversal, de asociación y correlación entre variables Padre-Hijo/a de carácter multicéntrico, en el cual participaron 140 sujetos (70 preescolares y su respectivo padre o madre). Las variables fueron estado nutricional, composición corporal, fuerza prensil y presión arterial de padres/madres y sus hijos/as preescolares y variables sociodemográficas de las familias. Resultados: Existió diferencia significativa al 5% respecto de la obesidad de los padres con la de los hijos/as, se presentó correlación positiva (0,397) entre las variables "porcentaje de grasa" padres e hijos/as. En relación al "nivel de escolaridad de la madre" hubo diferencia significativa con el "porcentaje de grasa" de los hijos/as (p<0,011). Existió similarmente diferencia significativa (p=0,033) entre la variable "tener hermanos" respecto a la variable "porcentaje de grasa" de los hijos/as. Finalmente se presentó asociación entre "usa Tablet" (dispositivo audiovisual) y "presión arterial" de los hijos/as (p=0,030). La variable "usa Tablet" se asoció significativamente con la "fuerza prensil" de los hijos/as (p=0,044). Conclusiones: Padres obesos con alto porcentaje de grasa tienen hijos/as preescolares con bajo perfil cardiometabólico; las variables nivel educacional inferior de la madre y tener hermanos se asociaron a un mayor porcentaje de grasa en los hijos/as, conjuntamente el uso de Tablet en preescolares mostró mayores niveles de presión arterial y menor fuerza prensil(AU)

Introduction: Little is known about the association between cardiometabolic markers in preschoolers with family nutritional and socio- demographic characteristics. Objective: To determine the association between cardiometabolic markers in preschoolers and their parents with family nutritional and sociodemographic characteristics. Materials and methods: cross-sectional study of association and correlation between parent-child variables, multicenter, 140 subjects participated (70 preschoolers and their respective parents). The variables were nutritional status, body composition, prehensile strength and blood pressure of parents and their preschool children and sociodemographic variables of the families. Results: There was a significant difference at 5% between parents' obesity and children's obesity, with a positive correlation (0.397) between the variable "percentage of fat" parents/children. In relation to the "mother's level of schooling" there was a significant difference with the "percentage of fat" of the children (p<0.011). Similarly, there was a significant difference (p=0.033) between the variable "Having siblings" with respect to the variable "percentage of fat" of the children. Finally, there was an association between "Tablet use" (audiovisual device) and "blood pressure" of the children (p=0.030). The variable "Tablet use" was significantly associated with the "prehensile strength" of the children (p=0.044). Conclusions: Obese parents with a high percentage of fat have preschool children with a low cardiometabolic profile; the variables lower educational level of the mother and having siblings were associated with a higher percentage of fatness in children; together, the use of Tablet in preschoolers showed higher levels of blood pressure and lower prehensile strength(AU)

Folate and vitamin B12 related to homocysteine and DNA damage in female university students / Folato e vitamina B12 relacionados com homocisteína e danos no DNA em estudantes universitárias / Folato y vitamina B12 relacionados con homocisteína y daño en el ADN en estudiantes universitarias

Background and Objectives: It is not clear whether the increase in nutrition students' knowledge is associated with healthier eating behavior and fewer micronutrient deficiencies that can cause DNA damage. Deficiency in some vitamins can be a risk factor for increased homocysteine (Hcy) levels, a marker of cardiovascular risk. Therefore, this study aimed to verify whether dietary and serum folate and vitamin B12 are associated with Hcy levels and DNA damage in female university students. Methods: A cross-sectional study was conducted with female university students from southern Brazil. Folate, vitamin B12, and Hcy levels were determined in their diet or serum. DNA damage levels were assessed by the alkaline comet assay (index and frequency) and the buccal micronucleus assay (micronuclei frequency and binucleated cells frequency). Results: Correlation analyses did not show an association between Hcy levels and dietary or serum folate and vitamin B12 consumption. Dietary folate and vitamin B12 were associated with the index and frequency of damages; however, only serum folate was negatively associated with the index and frequency of damages. Additionally, the frequency of binucleated cells was negatively associated with dietary vitamin B12 and positively associated with serum levels. Serum folate was negatively associated with the frequency of micronuclei. Hcy levels were associated with the index and frequency of damages. Conclusion: These findings strengthen the role of healthier dietary patterns with adequate micronutrients as a preventive strategy to reduce the risk of cardiovascular diseases. This approach should play a pivotal role in shaping health policies and advocating for appropriate food choices.(AU)

Justificativa e Objetivos: Não está claro se o aumento do conhecimento dos estudantes de nutrição está associado a um comportamento alimentar mais saudável, com menores deficiências de micronutrientes que podem induzir danos no DNA. A deficiência de algumas vitaminas pode ser um fator de risco para o aumento dos níveis de homocisteína (Hcy), um marcador de risco cardiovascular. Portanto, este estudo verificou se folato e vitamina B12 dietético e sérico estão associados aos níveis de Hcy e danos no DNA em estudantes universitárias. Métodos: Estudo transversal com universitárias do sul do Brasil. Determinou-se folato, vitamina B12 e Hcy dietético e séricos. Os níveis de danos no DNA foram avaliados pelo ensaio do cometa alcalino (índice e frequência) e pelo ensaio de micronúcleos bucais (frequência de micronúcleos e células binucleadas). Resultados: Análises de correlação não mostraram associação entre os níveis de Hcy com o consumo de folato e vitamina B12 dietético ou sérico. Folato e vitamina B12 dietéticos associou-se ao índice e frequência de danos, entretanto, somente folato sérico associou-se negativamente ao índice e frequência de danos. Ainda, a frequência de células binucleadas estava negativamente associada à vitamina B12 da dieta e positivamente associada aos níveis séricos. Folato sérico associou-se negativamente à frequência de micronúcleos. Os níveis de Hcy associou-se ao índice e frequência de danos. Conclusão: Esses achados fortalecem o papel de padrões alimentares mais saudáveis com micronutrientes adequados como estratégia preventiva visando a redução do risco de doenças cardiovasculares. Esta abordagem deve desempenhar um papel fundamental na formulação de políticas de saúde e na defesa de escolhas alimentares apropriadas.(AU)

Justificación y Objetivos: No está claro si el aumento del conocimiento de estudiantes de nutrición está asociado con un comportamiento alimentario más saludable, con menores deficiencias de micronutrientes que puedan inducir daños en ADN. La deficiencia de algunas vitaminas puede ser un factor de riesgo para el aumento de los niveles de homocisteína (Hcy), marcador de riesgo cardiovascular. Consiguiente, este estudio verificó si folato y vitamina B12 dietéticos y séricos están asociados con niveles de Hcy y daños en el ADN en estudiantes universitarias. Métodos: Estudio transversal con universitarias del sur de Brasil. Se determinaron folato, vitamina B12 y Hcy dietéticos y séricos. Los niveles de daño en el ADN se evaluaron por ensayo del cometa alcalino (índice y frecuencia) y el ensayo de micronúcleos bucales (frecuencia de micronúcleos y células binucleadas). Resultados: Los análisis de correlación no mostraron asociación entre los niveles de Hcy con folato y vitamina B12 dietéticos y séricos. Folato y vitamina B12 dietéticos se asociaron con índice y frecuencia de daños, pero, solo folato sérico se asoció negativamente con índice y frecuencia de daños. Además, la frecuencia de células binucleadas estaba negativamente asociada con la vitamina B12 de la dieta y positivamente asociada con los niveles séricos. Folato sérico se asoció negativamente con la frecuencia de micronúcleos. Los niveles de Hcy se asociaron con índice y frecuencia de daños. Conclusión: Estos hallazgos refuerzan el papel de patrones alimentarios más saludables con micronutrientes adecuados como estrategia preventiva para reducir el riesgo de enfermedades cardiovasculares. Este enfoque debería desempeñar un papel fundamental en la elaboración de políticas de salud y en la promoción de elecciones alimenticias apropiadas.(AU)

Asociación entre los marcadores lipídicos en la infancia/ adolescencia y los eventos cardiovasculares en la adultez: una revisión sistemática / Association between lipid markers in childhood/ adolescence and cardiovascular events in adulthood: A systematic review

Introducción. La asociación entre los marcadores lipídicos en la infancia/adolescencia y la incidencia de eventos clínicos cardiovasculares en la adultez está poco explorada en la literatura. El objetivo de esta revisión sistemática fue analizar la evidencia disponible sobre este tema. Población y métodos. Esta revisión sistemática se realizó de acuerdo con las guías PRISMA. Se realizó una búsqueda bibliográfica para detectar los estudios que evaluaron la asociación entre los niveles lipídicos en la edad pediátrica y la incidencia de eventos cardiovasculares en la edad adulta. No hubo restricciones idiomáticas ni geográficas en la búsqueda. Resultados. En total, cinco estudios observacionales (todas cohortes prospectivas) que incluyeron 43 540 pacientes fueron identificados y considerados elegibles para este estudio. Cuatro estudios evaluaron el nivel de triglicéridos; todos reportaron una asociación significativa entre este marcador en la edad pediátrica y los eventos cardiovasculares en la adultez. Un estudio reportó la misma asociación con el nivel de colesterol total, mientras que otro evidenció el valor predictivo de la lipoproteína (a) para el mismo desenlace clínico. Un solo estudio evaluó el colesterol asociado a lipoproteínas de alta densidad (C-HDL), sin encontrar una relación con el punto final de interés. El análisis del colesterol asociado a lipoproteínas de baja densidad (C-LDL) arrojó resultados contradictorios, aunque la asociación fue significativa en los estudios con un tamaño muestral más grande y con un mayor número de eventos durante el seguimiento. Conclusión. Los datos de esta revisión sugieren que las alteraciones de los marcadores lipídicos en la infancia y la adolescencia se asocian con un mayor riesgo cardiovascular en la adultez temprana y media.

Introduction. The association between lipid markers in childhood/adolescence and the incidence of clinical cardiovascular events in adulthood has been little explored in the bibliography. The objective of this systematic review was to analyze available evidence on this topic. Population and methods. This systematic review was conducted in accordance with the PRISMA guidelines. A comprehensive bibliographic search was done to find studies assessing the association between lipid levels in childhood and the incidence of cardiovascular events in adulthood. There were no language or geographic restrictions. Results. A total of 5 observational studies (all prospective cohorts) including 43 540 patients were identified and considered eligible for this study. Four studies assessed triglyceride levels; all reported a significant association between this lipid marker in childhood and cardiovascular events in adulthood. A study reported the same association with total cholesterol level, while another showed the predictive value of lipoprotein (a) for the same clinical outcome. Only one study assessed high-density lipoprotein cholesterol (HDL-C), but it did not find an association with the endpoint of interest. The analysis of lowdensity lipoprotein cholesterol (LDL-C) showed contradictory results, although the association was significant in the studies with a larger sample size and a higher number of events during follow-up. Conclusion. According to this review, alterations in lipid markers in childhood and adolescence are associated with a higher cardiovascular risk in early and middle adulthood.

Impacto de la pandemia COVID 19 en los factores de riesgo cardiovasculares y en la salud mental en usuarios de consulta privada cardiológica / Impact of the COVID-19 pandemic on cardiovascular risk factors and mental health in patients undergoing private cardiology consultation

Antecedentes: La pandemia de Covid-19 se ha convertido en uno de los desastres de salud, económicos y sociales más grandes de la historia de la humanidad. En este contexto se evidencia un aumento sustancial de trastornos emocionales diversos como, la ansiedad, la depresión, estrés y agotamiento emocional. Es preocupante el impacto que puede representar en los pacientes con factores de riesgo cardiovasculares (FRCV) durante la emergencia sanitaria. Objetivo: Analizar el impacto de la pandemia Covid 19 en los FRCV y en la salud mental en usuarios de consulta privada cardiológica. Método: Estudio observacional, analítico de corte transversal. Población objetivo 100 usuarios atendidos en consulta privada cardiológica, todos con consentimiento informado. Muestra no probabilística por conveniencia. Se realizó encuesta DASS-21 intra pandemia Covid 19 para medición de depresión, ansiedad y estrés. Medición antropométrica y exámenes de glicemia, insulinemia, hemoglobina glicosilada (HbA1c), perfil lipídico y presión arterial, para los periodos pre pandemia (PP) e intra pandemia (IP) Covid 19. Se usó software Stata para el análisis estadístico de medidas de tendencia central y el análisis bivariado con prueba de Chi2. Resultados: La muestra incluyó 100 usuarios: 51,5% de género femenino, y el promedio de edad fue 60,8 ±13,7 años. El nivel socioeconómico (NSE) fue Alto en 55,5%. El 63,6% presentaban nivel de escolaridad enseñanza superior (NEES). Al analizar ambos periodos, PP e IP, los resultados con mayor relevancia fueron: presión arterial (PA) alterada 16,6% en PP y 22,9% en IP; sobrepeso/obesidad 65,8% en PP y 70,7% en IP; HbA1c 16,6% PP y 31,9% en IP; insulinemia alterada 15,7% PP y 21% en IP; colesterol no HDL alterado 50,5% en PP y 52,7% en IP; índice HOMA alterado 44,5% en PP y 54,3% en IP. Se evidenció un importante aumento en trastornos de salud mental en IP que fueron depresión leve/moderada en 20% y depresión severa/extremadamente severa en 11%; ansiedad leve/moderada 25% y ansiedad severa/extremadamente severa 22%, estrés leve/moderado 21% y estrés severo/extremadamente severo 18%. Conclusiones: En el periodo IP hubo una alteración estadísticamente significativa en las variables clínicas como PA, HbA1c, índice HOMA, insulinemia, colesterol noHDL y sobrepeso/obesidad. En el periodo IP hubo un alto porcentaje de depresión, ansiedad y estrés, especialmente en mujeres. La pandemia por Covid 19 ha tenido impacto en los FRCV y en la salud mental en usuarios del sistema privado de salud.

Background: The Covid-19 pandemic has become one of the largest health, economic, and social disasters in human history. In this context, there has been a substantial increase in various emotional disorders such as anxiety, depression, stress, and emotional exhaustion. Given these issues, there is concern about the impact this may have on patients with cardiovascular risk factors (CVRF) during this health emergency. Objective: To analyze the impact of the COVID-19 pandemic on CVRF and mental health in subjects undergoing private cardiology consultation. Method: Observational, analytical, cross-sectional study. The target population consisted of 100 users attending a private cardiology consultation, all of them giving informed consent, with anon-probabilistic convenience sample. DASS-21 survey was conducted during the COVID-19 pandemic to evaluate depression, anxiety, and stress. Anthropometric measurements and tests for glycemia, insulinemia, glycosylated hemoglobin (HbA1c), lipid profile, and blood pressure were performed for the pre-pandemic (PP) and during-pandemic (IP) COVID-19 periods. Statistical analysis, measures of central tendency, and bivariate analysis with Chi2 test. was performed using a Stata software package. Results: The sample consisted of 100 subjects, 51.5% female, with an average age of 60.8 ± 13.7 years. Subjects had a high socio-economic Level (SEL)in 55.5% and higher education level in 63.6%. Comparing PP and IP periods, the most relevant results, re were respectivly: altered blood pressure (BP) 16.6% vs 22.9%, overweight/obesity 65.8% vs 70.7%, HbA1c 16.6% vs 31.9%, altered insulinemia 15.7% vs 21%, altered non-HDL cholesterol 52.7%, vs 50.5%, and HOMA index 44.5% vs 54.3%. A significant increase in mental health disorders in IP was evidenced, which were: mild/moderate depression 20%, and severe/extremely severe depression 11%; mild/moderate anxiety 25%, and severe/extremely severe anxiety 22%, mild/moderate stress 21%, and severe/ extremely severe stress 18%. Conclusions: In the IP phase there was a statistically significant alteration in clinical variables such as BP, HbA1c, HOMA index, insulinemia, non-HDL cholesterol, and overweight/ obesity. Also, a high percentage of depression, anxiety, and stress was observed. The COVID-19 pandemic has impacted CVR and mental health in subjects being cared for in the private health system.

Expert consensus on fundus photograph-based cardiovascular risk assessment using artificial intelligence technology / 中华内科杂志

Cardiovascular risk assessment is a basic tenet of the prevention of cardiovascular disease. Conventional risk assessment models require measurements of blood pressure, blood lipids, and other health-related information prior to assessment of risk via regression models. Compared with traditional approaches, fundus photograph-based cardiovascular risk assessment using artificial intelligence (AI) technology is novel, and has the advantages of immediacy, non-invasiveness, easy performance, and low cost. The Health Risk Assessment and Control Committee of the Chinese Preventive Medicine Association, in collaboration with the Chinese Society of Cardiology and the Society of Health Examination, invited multi-disciplinary experts to form a panel to develop the present consensus, which includes relevant theories, progress in research, and requirements for AI model development, as well as applicable scenarios, applicable subjects, assessment processes, and other issues associated with applying AI technology to assess cardiovascular risk based on fundus photographs. A consensus was reached after multiple careful discussions on the relevant research, and the needs of the health management industry in China and abroad, in order to guide the development and promotion of this new technology.

Interrelationship of Sarcopenia and Cardiovascular Diseases: A review of potential mechanisms and management / Journal of the ASEAN Federation of Endocrine Societies

@#Sarcopenia refers to an age-related reduction of lean body mass. It showed a reciprocal relationship with cardiovascular diseases. Thus, it is imperative to explore pathophysiological mechanisms explaining the relationship between sarcopenia and cardiovascular diseases, along with the clinical assessment, and associated management. In this review, we discuss how processes such as inflammation, oxidative stress, endothelial dysfunction, neural and hormonal modifications, as well as other metabolic disturbances influence sarcopenia as well as its association with cardiovascular diseases. Moreover, this review provides an overview of both non-pharmacological and pharmacological management for patients with sarcopenia and cardiovascular diseases, with a focus on the potential role of cardiovascular drugs to mitigate sarcopenia.

Nutritional evaluation of therapeutic diets for cardiovascular diseases in hospitals of General Santos City, Philippines: A comparative cross-sectional study

Objective@#This study aimed to evaluate the nutritional adequacy and compliance with cardiovascular disease (CVD) guidelines in therapeutic diets implemented in four hospitals in General Santos City, Philippines. @*Methods@#The study employed a cross-sectional study and analyzed the one-day therapeutic menus of four hospitals using the Philippine Food Composition Table and the United States Department of Agriculture nutrient database. The nutrient contents calculated in this study were compared among hospitals and benchmarked against the Philippine Dietary Reference Intakes (PDRI) and CVD-specific guidelines, the Dietary Approaches to Stop Hypertension (DASH), and Therapeutic Lifestyle Changes (TLC). The nutrient adequacy ratios (NARs) and the corresponding mean (SD) values were used to interpret the data.

Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.

Acciones impostergables sobre las enfermedades cardiovasculares en Cuba / Imperative Actions on Cardiovascular Diseases in Cuba

Las enfermedades cardiovasculares afectan el corazón y los vasos sanguíneos producto de la interacción combinada de factores de riesgos metabólicos, conductuales, socioeconómicos y ambientales como son: la presión arterial elevada, dieta no saludable, colesterol alto, diabetes, obesidad, hábito de fumar, enfermedad renal, estrés, consumo de alcohol y la poca actividad física entre otros. El número de muertes por enfermedades cardiovasculares en 2019 representó el 33 por ciento de las muertes globales, por la cardiopatía isquémica con 9,1 millones y el accidente vascular cerebral con 6,6 millones representaron el 85 por ciento de las muertes cardiovasculares mundialmente. A pesar de que las tasas estandarizadas de mortalidad ajustadas por edad se han reducido entre los años 2000-2019, el número total de fallecidos se ha incrementado en un 25 por ciento debido a el envejecimiento poblacional, el incremento de la población y la mayor incidencia de eventos fatales en pacientes con diabetes mellitus.1,2 Este envejecimiento poblacional es de particular importancia, la Organización Mundial de la Salud (OMS) estima que para el 2030 el número de personas mayores de 60 años estará en un 34 por ciento mayor con 1,4 mil millones y para el 2050 se duplicaría a 2,2 mil millones.3 El Atlas de Obesidad Mundial del 2023 estima que para el 2035 los niveles de sobrepeso y obesidad alcanzarán los 4 mil millones de personas comparados con los 2,6 mil millones en el 2020. El Diabetes Collaborators 2021estima que el número de pacientes que viven con diabetes puede llegar a 1,3 mil millones de personas comparado con los 529 millones existentes en el 2021.4,5 Estos datos demuestran la necesidad de incrementar...(AU)

Cyanobacteria for cardiomyocyte protection against miocardial ischemia injury: a systematic review of animal and in vitro studies / Cianobactérias para a proteção de cardiomiócitos contra lesões isquêmicas miocárdicas: uma revisão sistemática de estudos em animais e in vitro

Objective: To perform a systematic review on using Cyanobacteria for protecting the cardiac tissue against damage caused by ischemia.Methods: this review encompasses in vitro and controlled animal experimental studies. Results: the results show that in general there are two types of interventions for treatment of ischemia and Ischemia/Reperfusion (IR) in cardiac tissue: (1) extracts treatments and (2) injection of Cyanobacteria in the damaged tissues. Extract treatments are based on the antioxidant potential of Cyanobacteria, and the studies focus mainly on Spirulina (Arthrospira platensis). The direct injection methods are based on the high capacity of these organisms to release oxygen during photosynthesis. Synechococcus elongatus is the Cyanobacteria species most commonly utilized in injections, either delivered independently or carried by hydrogels or nanoparticles. The direct Cyanobacteria injections are innovative techniques which can promote protection against apoptosis and have shown promising results, however, further research is necessary to refine the techniques and improve overall efficacy. Conclusion: the effects of these treatments were beneficial considering that the antioxidant effects of Cyanobacteria ameliorate blood biochemical markers and reduce damaged cardiac areas. The oxygen releasing of Cyanobacteria in the cardiac tissue also promoted recovery of cardiac tissue after ischemia or IR

Objetivo: realizar uma revisão sistemática sobre o uso de cianobactérias para proteção do tecido cardíaco contra danos causados pela isquemia. Métodos: esta revisão abrange estudos experimentais in vitro e estudos controlados em animais. Resultados: os resultados indicam que, em geral, existem dois tipos de intervenções para o tratamento de isquemia e isquemia/reperfusão (IR) no tecido cardíaco: (1) tratamentos com extratos e (2) injeção de cianobactérias nos tecidos danificados. Os tratamentos com extratos baseiam-se no potencial antioxidante das cianobactérias, e os estudos concentram-se principalmente em Spirulina (Arthrospira platensis). Os métodos de injeção direta são fundamentados na alta capacidade desses organismos de liberar oxigênio durante a fotossíntese. Synechococcus elongatus é a espécie de cianobactéria mais comumente utilizada em injeções, seja entregue de forma independente ou transportada por hidrogéis ou nanopartículas. As injeções diretas de cianobactérias são técnicas inovadoras que podem promover proteção contra a apoptose e mostraram resultados promissores, no entanto, mais pesquisas são necessárias para aprimorar as técnicas e melhorar a eficácia geral. Conclusão: os efeitos desses tratamentos foram benéficos, considerando que os efeitos antioxidantes das Cianobactérias melhoram os marcadores bioquímicos sanguíneos e reduzem as áreas cardíacas danificadas. A liberação de oxigênio pelas cianobactérias no tecido cardíaco também promoveu a recuperação do tecido após isquemia ou IR

Demandas e recursos para predição da síndrome de burnout em psicólogos clínicos / Demands and resources for burnout syndrome on clinical psychologists / Demandas y recursos para la predicción del síndrome de burnout en psicólogos clínicos

O modelo de demandas e recursos foi utilizado para identificar o poder preditivo do estilo pessoal do terapeuta e do trabalho emocional (demandas), e da inteligência emocional e autoeficácia profissional (recursos) sobre as dimensões da síndrome de Burnout (SB), em uma amostra de 240 psicólogos clínicos brasileiros. Os dados foram coletados por meio de plataforma online, tendo como instrumentos de pesquisa um Questionário de dados sociodemográficos e laborais, o Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo, o Cuestionario del Estilo Personal del Terapeut, o Questionário de Avaliação Relacionado a Demandas Emocionais e Dissonância da Regra da Emoção, Medida de Inteligência Emocional, e Escala de Autoeficácia Geral Percebida. Os resultados obtidos revelaram um modelo preditor das dimensões da SB, constituído pelas variáveis dissonância emocional, automotivação, demandas emocionais, instrução, envolvimento e autoeficácia. Ressalta-se a relevância de estratégias voltadas para a prevenção da SB nessa categoria profissional, bem como a necessidade de ações que visem a promoção e o desenvolvimento da inteligência emocional e da autoeficácia como fortalecimento dos recursos emocionais para atuação na prática clínica.(AU)

The Model of Demands - Resources was used to identify the predictive power of therapist's personal style, emotional work (Demands), Emotional intelligence, and professional self-efficacy (Resources) over the Burnout syndrome dimensions in a sample of 240 Brazilian clinical psychologists. The data was collected by an on-line platform using a Labor and social demographic data questionnaire, a work Burnout Syndrome Evaluation questionnaire (CESQT - Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo), the short version of the Therapist Personal Style Questionnaire (EPT-C Cuestionario del Estilo Personal del Terapeuta), an Evaluation questionnaire related to emotional demands and emotion rule dissonance, and the Emotional Intelligence Measure (EIM) and Perceived General Self-Efficacy Scale (GPSS) as research instruments. Results showed a predictor model of Burnout syndrome constituted by the variables Emotional dissonance, Self-motivation, Emotional demands, Instruction, Involvement, and Self-efficacy. We emphasize the relevance of strategies to prevent Burnout Syndrome in this professional category and the need for actions to promote and develop emotional intelligence and self-efficacy as a strengthening factor of the emotional resources to work as a clinical psychologist.(AU)

Se utilizó el modelo demandas y recursos para identificar el poder predictivo del estilo personal del terapeuta y del trabajo emocional (demandas), y de la inteligencia emocional y autoeficacia profesional (recursos) sobre las dimensiones del síndrome de Burnout (SB), en una muestra de 240 psicólogos clínicos brasileños. Los datos se recolectaron de una plataforma en línea, utilizando como instrumentos de investigación un cuestionario de datos sociodemográficos y laborales, el Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo, el Cuestionario del Estilo Personal del Terapeuta, el Cuestionario de Evaluación Relacionado con Demandas Emocionales y Disonancia de la Regla de la Emoción, la Medida de Inteligencia Emocional y Escala de Autoeficacia General Percibida. Los resultados obtenidos revelaron un modelo predictor de las dimensiones de SB, constituido por las variables disonancia emocional, automotivación, exigencias emocionales, instrucción, implicación y autoeficacia. Se destaca la relevancia de las estrategias dirigidas a la prevención del SB en esta categoría profesional, así como la necesidad de acciones dirigidas a promover y desarrollar la inteligencia emocional y la autoeficacia como fortalecimiento de los recursos emocionales para trabajar en la práctica clínica.(AU)

Índices para avaliar dietas sustentáveis e promotoras de saúde cardiovascular: desenvolvimento, validação e aplicação / Indices for evaluating sustainable and cardiovascular health-promoting diets: development, validation, and application

Introdução: Índices de avaliação da dieta são instrumentos úteis para identificar a qualidade global da dieta e verificar se a adesão às recomendações dietéticas possui efeitos benéficos na saúde. Em 2019, a Comissão EAT-Lancet propôs um modelo de dieta sustentável, enquanto que a American Heart Association (AHA) possui recomendações dietéticas para promoção da saúde cardiovascular. No entanto, não existem índices baseados nestas recomendações. Objetivo: Desenvolver e validar dois índices de avaliação da dieta baseados na dieta sustentável do EAT-Lancet e nas recomendações dietéticas da AHA e sua aplicação na análise de associação com aterosclerose subclínica. Métodos: Foram utilizados dados do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil), uma coorte multicêntrica que acompanha 15.105 funcionários de seis instituições públicas de ensino e pesquisa. O consumo alimentar foi avaliado através de um Questionário de Frequência Alimentar (QFA). A aterosclerose subclínica foi avaliada através do escore de calcificação arterial coronariano (CAC) na linha de base (2008-2010) e na segunda onda (2012-2014) e a espessura médio-intimal das carótidas (IMT) na linha de base e na terceira onda (2017-2019). Para o desenvolvimento do Planetary Health Diet Index (PHDI), foram utilizadas as recomendações da Comissão EAT-Lancet e para o desenvolvimento do Cardiovascular Health Diet Index (CHDI), foram utilizadas as recomendações dietéticas da American Heart Association. Após o desenvolvimento dos índices, técnicas de validade e confiabilidade interna foram empregadas. Para avaliar os fatores associados aos índices, foram empregados modelos de regressão linear simples e múltiplos. Modelos de Poisson com variância robusta foram construídos para avaliar a associação entre os índices e a incidência e progressão do CAC, enquanto modelos lineares mistos foram construídos para avaliar os índices e as mudanças no IMT. Resultados: A população apresentou uma média de 60,4 pontos no PHDI (de uma variação possível de 0 - 150 pontos) e de 57,1 pontos no CHDI (de uma variação possível de 0 - 110 pontos). Análises de validade relativa e confiabilidade demonstraram que ambos os índices possuem desempenho satisfatórios, demonstrando boa validade e confiabilidade interna. Observou-se que as mulheres, os idosos, pessoas com maior renda per capita, prática de atividade física moderada e vigorosa apresentaram, em média, maiores pontuações. Ao passo que, os fumantes e as pessoas com sobrepeso e obesidade apresentaram, em média, menores pontuações em ambos os índices. Não foram observadas associações significantes entre o PHDI com CAC e IMT. No entanto, após um período médio de acompanhamento de 8 anos, um aumento de 10 pontos no CHDI foi associado a uma diminuição de 0,0023 mm (IC 95% -0,0045; -0,0002) no IMT. Nenhuma associação foi observada entre o escore CHDI e a incidência e progressão de CAC após um período de acompanhamento de 4 anos. Conclusões: Os resultados demonstram a validade dos índices propostos como ferramentas adequadas para avaliação da dieta. Foi possível observar que a adesão as recomendações de dieta sustentável e promotoras da saúde cardiovascular estão associadas com condições sociodemográficas e de estilo de vida. Além disso, maior adesão à uma dieta cardioprotetora está inversamente associada com um marcador de aterosclerose subclínica.

Introduction: Dietary indices are useful tools to identify the overall dietary quality and to verify whether adherence to dietary recommendations has beneficial effects on health. In 2019, the EAT-Lancet Commission proposed a sustainable diet model, while the American Heart Association (AHA) has dietary recommendations for promoting cardiovascular health. However, there are no indices based on these recommendations. Objective: To develop and validate two dietary indices based on the EAT-Lancet sustainable diet and AHA dietary recommendations and their application in analyzing associations with subclinical atherosclerosis. Methods: Data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), a multicenter cohort following 15,105 employees from six public teaching and research institutions, were used. Dietary intake was assessed through a Food Frequency Questionnaire (FFQ). Subclinical atherosclerosis was assessed through coronary artery calcification score (CAC) at baseline (2008-2010) and the second wave (2012-2014) and carotid intima media thickness (IMT) at baseline and the third wave (2017-2019). For the development of the Planetary Health Diet Index (PHDI), the recommendations of the EAT-Lancet Commission were used, and for the development of the Cardiovascular Health Diet Index (CHDI), the dietary recommendations of the American Heart Association were used. After index development, techniques of validity and internal reliability were employed. To assess factors associated with the indices, simple and multiple linear regression models were used. Poisson models with robust variance were constructed to assess the association between the indices and the incidence and progression of CAC, while mixed linear models were constructed to assess the indices and changes in IMT. Results: The population had a mean score of 60.4 points on the PHDI (out of a possible range of 0-150 points) and 57.1 points on the CHDI (out of a possible range of 0-110 points). Relative validity and reliability analyses demonstrated that both indices performed satisfactorily, showing good internal validity and reliability. It was observed that women, the elderly, individuals with higher per capita income, moderate and vigorous physical activity, on average, had higher scores. Conversely, smokers and overweight and obese individuals, on average, had lower scores on both indices. No significant associations were observed between the PHDI and CAC and IMT. However, after a mean follow-up period of 8 years, a 10-point increase in the CHDI was associated with a decrease of 0.0023 mm (95% CI -0.0045; -0.0002) in IMT. No association was observed between the CHDI score and the incidence and progression of CAC after a 4-year follow-up period. Conclusions: The results demonstrate the validity of the proposed indices as suitable tools for dietary assessment. It was possible to observe that adherence to sustainable diet and cardiovascular health-promoting recommendations is associated with sociodemographic and lifestyle conditions. Additionally, greater adherence to a cardioprotective diet is inversely associated with a marker of subclinical atherosclerosis.

Influência da menopausa, idade, etnia e do sexo sobre as lipoproteínas e suas subfrações nas três fases da vida (adolescentes, adultos e idosos) / Influence of menopause, age, ethnicity and sex on lipoproteins and their subfractions in the three stages of life (adolescents, adults and the elderly)

Introdução: A prevalência de doenças cardiovasculares tem crescido em todo o mundo. Além da hipercolesterolemia, fatores como o envelhecimento, menopausa, diferenças no metabolismo do colesterol entre homens e mulheres e entre etnias, provavelmente contribuem para as prevalências dessas doenças. Objetivo: Avaliar a influência da menopausa, da idade (adolescentes, adultos e idosos), do sexo e da etnia sobre as subfrações lipoproteicas aterogênicas. Métodos: Trata-se de um estudo transversal, de base populacional e amostra probabilística de residentes da cidade de São Paulo. Foram utilizados dados de participantes "ISA-CAPITAL 2015" que tiveram coleta de dados bioquímicos. Foram realizadas análises de partículas de LDL e HDL respectivamente, em 827 amostras. O tamanho das partículas de LDL e HDL foi determinado pelo sistema Lipoprint® System (Quantimetrix Corporation. Todos os testes estatísticos foram realizados com o auxílio do programa SPSS 16. Foi considerado significativo p<0,05. Resultados: As análises com adolescentes mostraram que as meninas apesar de possuírem maior IMC, CC e concentração de TG, apresentaram melhor perfil de subfrações de LDL (LDL grande% 17,8; LDL pequena% 1,7) do que os meninos (LDL grande% 13,5; LDL pequena% 3,4) p<0,001 e p=0,002, respectivamente. Entre os indivíduos adultos, foi identificado um perfil mais aterogênico entre homens, com maior percentual de LDL pequena, quando comparados às mulheres (4,9% vs 2,7%; p<0,001, respectivamente). Com relação à população idosa, os resultados demonstraram que apesar do avanço da idade, as idosas quando comparadas aos idosos possuíam maior concentração LDL grande (32,5mg/dL vs 28,5mg/dL; p=0,007 respectivamente). As mulheres idosas tiveram uma piora das subfrações lipoproteicas se comparadas com as mulheres adultas (razão de LDL mg/dL=12,3 mulheres adultas vs 10,7 mulheres idosas; p=0,002) se aproximando ao perfil mais aterogênico encontrado entre os homens (razão de LDLmg/dL=9,9 homens adultos vs 9,0 homens idosos; p=0,027). Entretanto, quando pareadas por homens de mesma idade, as mulheres idosas, ainda assim, demonstraram um perfil menos aterogênico do que os homens idosos (razão de LDL mg/dL=10,7 mulheres idosas vs 9,0 homens idosos; p=0,001). Ao analisar a presença de menopausa, foi identificado que as mulheres no período pós menopausa tiveram piora do perfil lipídico clássico com aumento do IMC (p=0,025), CC (p<0,001), glicose (p<0,001), PAS (p<0,001), PAD (p=0,005) e TG (p<0,001), assim como tiveram piora do perfil lipoproteico com diminuição de LDL grande% quando comparadas com as mulheres no período pré menopausa (17,6% vs 14,6%; p=0,001). Quanto à etnia, foi identificado que os indivíduos brancos apresentaram valores maiores para IMC (p=0,005), CC (p=0,001), glicose (p=0,015) e TG (p=0,010). Após ajustes para etnia, idade e IMC, houve associação positiva com HDL grande (=0,122; R2=0,013; p=0,001), demonstrando maior aterogenicidade entre os indivíduos brancos. Conclusão: Em todas as faixas etárias o sexo feminino apresentou perfil menos aterogênico quando comparado ao masculino. A presença de menopausa e da etnia branca demonstrou um perfil lipídico clássico e lipoproteico mais aterogênico.

Introduction: The prevalence of cardiovascular diseases has increased throughout the world. In addition to hypercholesterolemia, factors such as aging, menopause, differences in cholesterol metabolism between men and women and between ethnicities probably contribute to the prevalence of these diseases. Objective: To evaluate the influence of menopause, age (adolescents, adults and elderly), sex and ethnicity on atherogenic lipoprotein subfractions. Methods: This is a cross-sectional, population-based study with a probabilistic sample of residents of the city of São Paulo. Data from "ISA-CAPITAL 2015" participants who had biochemical data collected were used. LDL and HDL particle analyzes were carried out respectively in 827 samples. The size of LDL and HDL particles was determined using the Lipoprint® System (Quantimetrix Corporation. All statistical tests were performed with the aid of the SPSS 16 program. Was considered significant p<0.05. Results: Analyzes with adolescents showed that girls, despite having higher BMI, WC and TG concentration, presented a better profile of LDL subfractions (LDL large% 17.8; LDL small% 1.7) than boys (LDL large% 13.5; LDL small% 3.4) p<0.001 and p=0.002, respectively. Among adult individuals, a more atherogenic profile was identified among men, with a higher percentage of LDL small, when compared to women (4.9% vs 2.7%; p<0.001, respectively). Regarding the elderly population, the results demonstrated that despite advancing age, elderly women, when compared to elderly men, had a higher large LDL concentration (32.5mg/dL vs 28.5mg/dL; p=0.007 respectively). Elderly women had a worsening of lipoprotein subfractions compared to adult women (LDL ratio mg/dL=12.3 adult women vs 10.7 elderly women; p=0.002) approaching the more atherogenic profile found among men (LDLmg/dL ratio=9.9 adult men vs 9.0 elderly men; p=0.027). However, when paired with men of the same age, elderly women still demonstrated a less atherogenic profile than elderly men (LDL ratio mg/dL=10.7 elderly women vs 9.0 elderly men; p=0.001). When analyzing the presence of menopause, it was identified that women in the postmenopausal period had a worsening of the classic lipid profile with an increase in BMI (p=0.025), WC (p<0.001), glucose (p<0.001), SBP (p< 0.001), DBP (p=0.005) and TG (p<0.001), as well as a worsening of the lipoprotein profile with a reduction in LDL large when compared to women in the premenopausal period (17.6% vs 14.6%; p=0.001). Regarding ethnicity, it was identified that white individuals presented higher values for BMI (p=0.005), WC (p=0.001), glucose (p=0.015) and TG (p=0.010). After adjustments for ethnicity, age and BMI, there was a positive association with HDL large (=0.122; R2=0.013; p=0.001), demonstrating greater atherogenicity among white individuals. Conclusion: In all age groups, females presented a less atherogenic profile when compared to males. The presence of menopause and white ethnicity demonstrated a more atherogenic classic lipid and lipoprotein profile.

Mortalidade em domicílio durante pandemia de covid-19 / Home mortality during the COVID-19 pandemic / Muerte en el hogar durante la pandemia de COVID-19

Resumo O estudo investigou a mortalidade em domicílio durante a pandemia de SARS-CoV-2 em Santa Catarina, utilizando dados secundários do Serviço de Atendimento Móvel de Urgência caracterizando óbitos notificados pelas equipes. A análise dos dados, acessados no Portal da Transparência do governo estadual, revelou aumento nos óbitos atendidos pelas equipes de urgência na região. Destacou-se também incremento médio de 2,16/100 mil habitantes na taxa de mortalidade por doenças cardiovasculares inespecíficas entre 2019 e 2022, diferenciando Santa Catarina do restante do Brasil. Essa disparidade pode estar associada à falta de controle dos fatores de risco e comorbidades durante a pandemia. Os achados ressaltam a necessidade de medidas preventivas para mitigar os efeitos adversos sobre a mortalidade domiciliar e melhorar os serviços de saúde, especialmente em relação à equidade na distribuição de recursos escassos durante a pandemia.

Abstract The study investigated home mortality during the SARS-CoV-2 pandemic in Santa Catarina, using secondary data from the Mobile Emergency Care Service characterizing deaths reported by the teams. Analysis of the data, accessed via the state government's Transparency Portal, uncovered a rise in deaths attended to by emergency teams in the area. It also highlighted an average increase of 2.16 per 100,000 residents in the mortality rate attributable to non-specific cardiovascular diseases between 2019 and 2022, distinguishing Santa Catarina from the rest of Brazil. This contrast could be linked to inadequate management of risk factors and comorbidities during the pandemic. The findings underscore the need for preventive measures to alleviate adverse impacts on home mortality and enhance healthcare services, particularly concerning equity in the allocation of limited resources amid the pandemic.

Resumen El estudio investigó la muerte en el hogar durante la pandemia por SARS-CoV-2 en el estado de Santa Catarina, en Brasil, utilizando datos secundarios del Servicio de Atención Móvil de Urgencia que caracterizan las defunciones notificadas por los equipos. El análisis de los datos, a los que se tuvo acceso por medio del Portal de la Transparencia del gobierno estatal, puso de manifiesto un aumento en las muertes atendidas por los equipos de urgencia en la región. También se resaltó un incremento medio de 2,16/100.000 habitantes en la tasa de mortalidad por enfermedades cardiovasculares inespecíficas entre el 2019 y el 2022, lo que diferencia a Santa Catarina del resto de Brasil. Esta disparidad puede estar asociada a la falta de control de los factores de riesgo y comorbilidades durante la pandemia. Los hallazgos resaltan la necesidad de adoptar medidas preventivas para mitigar los efectos adversos sobre la muerte en el hogar y mejorar los servicios de salud, en especial con respecto a la equidad en la distribución de recursos escasos durante la pandemia.

El desempeño profesional del pediatra en la atención a los factores de riesgo cardiovascular / The professional performance of the pediatrician in the care of cardiovascular risk factors

Introducción: la atención integral a niños y adolescentes con factores de riesgo cardiovascular es un desafío para el desempeño profesional del pediatra en la atención primaria de salud. Objetivo: sistematizar los referentes teóricos que sustentan el desempeño profesional del pediatra de la atención primaria de salud para la atención a los factores de riesgo cardiovascular. Métodos: se realizó una revisión bibliográfica de enero de 2020 a julio de 2022. Se utilizaron las bases de datos Pubmed, SciELO y Google Académico, a través de la combinación de los operadores OR, AND y NOT; las palabras clave utilizadas fueron: enfermedades cardiovasculares, desempeño profesional, factores de riesgo, atención primaria de salud y pediatra. Se evaluaron artículos y páginas web en idioma español e inglés que hicieran referencia al tema de estudio, a través del título. Desarrollo: a partir de la sistematización de varios autores, se adoptaron enfoques teóricos en relación con el desempeño profesional del pediatra de la atención primaria de salud para la atención a los factores de riesgo cardiovascular, se identificaron regularidades en diferentes áreas del conocimiento y se propuso de manera operacional la definición del desempeño profesional del pediatra de la atención primaria de salud para la atención a los factores de riesgo cardiovascular. Conclusiones: la sistematización realizada permitió establecer una aproximación a los referentes teóricos que sustentan el tema y profundizar en el desempeño profesional del pediatra para la prevención de los factores de riesgo cardiovascular en los niños.

Background: comprehensive care for children and adolescents with cardiovascular risk factors is a challenge for the professional performance of pediatricians in primary health care. Objective: to systematize the theoretical references that support the professional performance of pediatricians in primary health care for the care of cardiovascular risk factors. Methods: a literature review was performed from January 2020 to July 2022. Pubmed, SciELO and Google Scholar databases were used, through the combination of OR, AND and NOT operators; the keywords used were cardiovascular diseases, professional performance, risk factors, primary health care and pediatrician. Articles and web pages in Spanish and English referring to the subject of the study were evaluated through the title. Development: based on the systematization of several authors, theoretical approaches were adopted in relation to the professional performance of the pediatrician in primary health care for the attention to cardiovascular risk factors, regularities were identified in different areas of knowledge and the definition of the professional performance of the pediatrician in primary health care for the attention to cardiovascular risk factors was proposed in an operational manner. Conclusions: the systematization made it possible to establish an approach to the theoretical references that support the subject and to deepen in the professional performance of the pediatrician for the prevention of cardiovascular risk factors in children.

Impacto da cardiopatia grave na sobrevida dos servidores aposentados por invalidez na Universidade Federal do Rio de Janeiro de 2003 a 2017 / Impact of severe heart disease on the survival of servants retired due to disability at the Federal University of Rio de Janeiro from 2003 to 2017

Introdução: A aposentadoria por invalidez é o benefício concedido aos servidores públicos quando considerados incapazes de forma permanente para o trabalho. As doenças não comunicáveis são a principal causa de incapacidade permanente e aposentadoria por invalidez no Brasil, com destaque para as doenças cardiovasculares. Em 2006, a Sociedade Brasileira de Cardiologia definiu os critérios de enquadramento das doenças cardiovasculares através da II Diretriz Brasileira de Cardiopatia Grave. Poucos são os estudos sobre este tema, envolvendo uma instituição federal, com regime jurídico próprio, planos de carreira, condições de trabalho e remunerações salariais distintos. Objetivo: Descrever o perfil demográfico, avaliar a mortalidade e analisar a sobrevida dos servidores aposentados por invalidez na Universidade Federal do Rio de Janeiro de 2003 a 2017, com ênfase na cardiopatia grave. Métodos: Foi realizado um estudo de coorte retrospectiva baseado nos registros das aposentadorias por invalidez e nas causas de óbitos dos servidores ao longo de 15 anos. As informações sobre os óbitos foram obtidas através do Subsistema Integrado de Atenção à Saúde do Servidor, SIAPENET, Sistema Integrado de Recursos Humanos e das Certidões de Óbito fornecidas pela Coordenação de Gestão de Pessoal da UFRJ. Adicionalmente, foram recolhidas informações do Sistema de Informações sobre Mortalidade do Estado do Rio de Janeiro. Os resultados foram apresentados em números absolutos e percentuais para variáveis categóricas, enquanto média, desvio-padrão e mediana foram utilizados para variáveis numéricas. A comparação entre variáveis categóricas foi realizada por meio do teste qui-quadrado. Para avaliar a diferença na variável idade entre os sexos e dentro de cada tipo de aposentadoria, empregou-se o teste de Mann-Whitney. Na comparação entre os cargos utilizou-se o teste de Kruskall-Wallis. Modelos de regressão logística univariada e multivariada foram utilizados para analisar os grupos de aposentadorias proporcionais e integrais e a associação com os dados demográficos. As taxas de mortalidade foram calculadas considerando o tempo total até o óbito, ajustadas pelo total de pessoas-ano por categoria e estimadas para cada variável. A sobrevida foi representada por meio de gráficos de Kaplan-Meier. Foram ajustados modelos univariados e multivariados de Cox para analisar a mortalidade em relação às variáveis, com cálculo dos hazard ratio brutos (HR) e ajustados (HRaj). A presença de diagnósticos concordantes na ocasião da aposentadoria e do óbito foi avaliada através do teste qui-quadrado. A significância estatística foi determinada com um intervalo de confiança de 95%, considerando um valor de p < 0,05. Resultados: Foram analisadas 630 aposentadorias, com 368 (51,4%) ocorrendo no sexo feminino. Do total, 334 (53%) foram integrais e 296 (47%) proporcionais. Na ocasião da aposentadoria, 499 (79,2%) servidores apresentaram idade entre 30 e 59 anos, com média de idade de 52,9 (dp = 7,8) anos. Nos cargos de nível superior houve maior ocorrência de aposentadorias integrais (p < 0,001), assim como nas faixas etárias mais elevadas (p < 0,001) e no sexo masculino (p = 0,012). Foram 169 (26,8%) óbitos. A mortalidade foi maior nos professores (37,0%; p = 0,113), entre 65 e 70 anos (48,4%; p = 0,004), no sexo masculino (34,0%; p = 0,001) e nas aposentadorias por cardiopatia grave (41,5%; p < 0,001). A média de sobrevida global foi de 15 anos após a aposentadoria. Diagnósticos concordantes foram observados entre as causas das aposentadorias e as causas dos óbitos, de acordo com o cargo e tipo de aposentadoria. Entre os cargos, as seguintes frequências foram observadas: 74% para os professores, 69% para os técnico-administrativos de nível superior e 49% para os de nível médio ou elementar (p = 0,026). Entre os tipos de aposentadorias as frequências foram: 72% nas integrais por cardiopatia grave, 70% nas integrais por outras causas e 16% nas proporcionais (p< 0,001). Conclusão: As doenças não comunicáveis predominaram como causa das aposentadorias por invalidez na Universidade Federal do Rio de Janeiro. Notavelmente, a média da idade de aposentadoria por invalidez foi precoce, independentemente do sexo e do tipo de aposentadoria. Além disso, servidores de cargos de nível médio ou elementar enfrentaram uma maior incidência de incapacidade permanente. O sexo feminino foi o mais afetado. A proporção de óbitos e a taxa de mortalidade demonstraram ser mais elevadas no cargo de professor, entre indivíduos do sexo masculino, nas faixas etárias mais avançadas e nos grupos de aposentadorias integrais por cardiopatia grave e integrais por outras doenças. Notou-se, nestes últimos grupos, uma frequência mais significativa de diagnósticos concordantes entre a condição que levou à aposentadoria e a causa do falecimento do servidor. Houve um aumento substancial no risco de mortalidade em casos de aposentadoria integral. Em contrapartida, a sobrevida foi estendida em situações de aposentadoria precoce e quando a aposentadoria é proporcional.(AU)

Introduction: Disability retirement is the benefit granted to public servants when deemed permanently incapable of work. Noncommunicable diseases are the leading cause of permanent disability and disability retirement in Brazil, particularly cardiovascular diseases. In 2006, the Brazilian Society of Cardiology established criteria for the classification of cardiovascular diseases through the II Brazilian Guideline for Severe Heart Disease. There are few studies on this subject, especially involving a federal institution with its own legal framework, career plans, distinct working conditions, and salary progression. Goals: To describe the demographic profile, assess mortality, and analyze the survival of retired employees due to disability at the Federal University of Rio de Janeiro from 2003 to 2017, with emphasis on severe heart disease. Methods: A retrospective cohort study was conducted based on the records of disability retirements and causes of death of public servants over 15 years. The information regarding deaths was obtained through the Integrated Health Care Subsystem for Civil Servants, SIAPENET, the Integrated Human Resources System, and death certificates provided by the Personnel Management Coordination of UFRJ. Additionally, data from the Mortality Information System of the State of Rio de Janeiro were collected. The results were presented in absolute and percentage numbers for categorical variables, while mean, standard deviation, and median were used for numerical variables. The comparison between categorical variables was conducted through the chi-square test. The Mann-Whitney test was employed to assess the difference in age between genders and within each type of retirement. In comparing job positions, the Kruskall-Wallis test was used. Univariate and multivariate logistic regression models were applied to analyze proportional and full retirement groups and their association with demographic data. Mortality rates were calculated considering the total time until death, adjusted for total person-years per category, and estimated for each variable. Survival was depicted through Kaplan-Meier graphs. Univariate and multivariate Cox models were adjusted to analyze mortality in relation to variables, calculating crude (HR) and adjusted hazard ratios (HRaj). The presence of concordant diagnoses at the time of retirement and death was assessed using the chi-square test. Statistical significance was determined with a 95% confidence interval, considering a pvalue of < 0.05. Results: A total of 630 retirements were analyzed, 368 (51.4%) being female servants. Of the total, 334 (53%) were full retirements and 296 (47%) were proportional. It was observed that 499 (79.2%) of the servants retired between the ages of 30 and 59, with an average age of 52.9 (SD = 7.8) years. Positions related to higher academic level were associated with full retirements (p < 0.001), as did older age groups (p < 0.001) and servants being male (p = 0.012). A total of 169 (26.8%) deaths were recorded. Mortality was higher among teachers (37.0%; p = 0.113), in the age group between 65 and 70 years (48.4%; p = 0.004), males (34.0%; p = 0.001), and retirements from severe cardiopathyrelated (41.5%; p < 0.001). The overall average survival was 15 years. Concordant diagnoses were observed between the causes of retirements and the causes of deaths, according to the position and type of retirement. Among the positions, the following frequencies were observed: 74% for teachers, 69% for higher-level technical-administrative ones and 49% for those with secondary or elementary level (p = 0.026). Among the types of retirements, the frequencies were: 72% for full retirements due to severe heart disease, 70% for full retirements due to other causes, and 16% for proportional retirements (p < 0.001). Conclusions: Noncommunicable diseases predominated as the cause of disability retirements at the Federal University of Rio de Janeiro. Remarkably, the average age of disability retirement was early, regardless of gender and type of retirement. Additionally, employees in middle or elementary level positions faced a higher incidence of permanent disability. The female gender was the most affected. The proportion of deaths and the mortality rate were higher in the professorship position, among male individuals, in older age groups, and in full retirements due to severe heart disease and other illnesses. In these latter groups, a more significant frequency of consistent diagnoses between the condition leading to retirement and the cause of the employee's death was noted. There was a substantial increase in mortality risk in cases of full retirement. Conversely, survival was extended in situations of early retirement and when retirement is proportional.(AU)