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1.
Rev. enferm. UERJ ; 27: e45014, jan.-dez. 2019. tab
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1097364

ABSTRACT

Objetivo: avaliar a qualidade de vida de indivíduos portadores de dispositivo cardíaco eletrônico implantável. Método: estudo descritivo e transversal realizado com 50 indivíduos em 2018. Utilizou-se o SF-36 e AQUAREL. Resultados: a comorbidade mais frequente foi a hipertensão arterial sistêmica ­ 39 (78%), a cardiopatia de base a bradicardia ­ 18 (36%) e queixas de palpitação e pré-síncope. Predominaram indivíduos com tempo do dispositivo cardíaco eletrônico de até 5 anos ­ 24 (48%), sem troca de gerador ­ 31 (62%). A maioria negou o consumo de bebida alcóolica ­ 47 (94%), de cigarros ­ 44 (88%) e não realiza atividade física regular ­ 34 (68%). No SF-36, o menor escore foi no domínio aspectos físicos (15) e o maior em dor (88,8). No AQUAREL o menor escore foi no domínio dispneia (78,98) e o maior em desconforto (86,54). Conclusão: constatou-se sintomatologia reduzida. Houve associação significativa entre sexo masculino e atividade física. Os indivíduos apresentam melhora da qualidade de vida após a implantação do dispositivo cardíaco.


Objective: to evaluate the quality of life of individuals with implantable electronic cardiac devices. Method: descriptive and cross-sectional study conducted with 50 individuals in 2018. SF-36 and AQUAREL were used. Results: the most frequent comorbidity was systemic arterial hypertension ­ 39 (78%), baseline heart disease bradycardia ­ 18 (36%) and complaints of palpitation and pre-syncope. Individuals with electronic cardiac device time of up to 5 years 24 (48%) predominated, without changing the generator ­ 31 (62%). The majority denied alcohol consumption ­ 47 (94%), cigarettes ­ 44 (88%) and regular physical activity ­ 34 (68%). In the SF-36 the lowest score was in the physical aspects domain (15) and the highest in pain (88.8). In AQUAREL the lowest score was in the domain dyspnea (78.98) and the highest in discomfort (86.54). Conclusion: reduced symptomatology was observed. There was a significant association between males and physical activity. Individuals have improved quality of life after implantation of the cardiac device.


Objetivo: evaluar la calidad de vida de las personas con dispositivos cardíacos electrónicos implantables. Método: estudio descriptivo y transversal realizado con 50 individuos, en 2018. SF-36 y AQUAREL se utilizaron. Resultados: la comorbilidad más frecuente fue la hipertensión arterial sistémica ­ 39 (78%), las cardiopatías subyacentes, bradicardia ­ 18 (36%) y quejas de palpitación y presíncope. Predominan los individuos con tiempo de dispositivo cardíaco electrónico de hasta 5 años ­ 24 (48%) sin cambiar el generador ­ 31 (62%). La mayoría negó el consumo de alcohol ­ 47 (94%), cigarrillos ­ 44 (88%) y actividad física regular 34 (68%). En el SF-36, la puntuación más baja estaba en el dominio de aspectos físicos (15) y la más alta en dolor (88.8). En AQUAREL, la puntuación más baja estaba en el dominio disnea (78,98) y la más alta en malestar (86,54). Conclusión: se observó una sintomatología reducida. Hubo una asociación significativa entre los varones y la actividad física. Los individuos han mejorado la calidad de vida después de la implantación del dispositivo cardíaco.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Pacemaker, Artificial , Quality of Life , Electric Countershock , Cardiac Pacing, Artificial , Cardiovascular Diseases/therapy , Cardiac Resynchronization Therapy Devices , Cardiovascular Diseases/complications
2.
J. pediatr. (Rio J.) ; 95(6): 696-704, Nov.-Dec. 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1056663

ABSTRACT

ABSTRACT Objective: To assess the carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease. Material and methods: Observational, cross-sectional study carried out at the Universidade Federal de São Paulo (chronic kidney disease outpatient clinics) with 55 patients (60% males) with a median age of 11.9 years (I25-I75: 9.2-14.8 years). Of the 55 patients, 43 were on conservative treatment and 12 were on dialysis. Serum laboratory parameters (creatinine, uric acid, C-reactive protein, total cholesterol and fractions, and triglycerides), nutritional status (z-score of body mass index, z-score of height/age), body fat (fat percentage and waist circumference), and blood pressure levels were evaluated. The carotid intima-media thickness measure was evaluated by a single ultrasonographer and compared with percentiles established according to gender and height. Data collection was performed between May 2015 and March 2016. Results: Of the children and adolescents with chronic kidney disease, 74.5% (95% CI: 61.0; 85.3) showed an increase (>P95) in carotid intima-media thickness. In patients with stages I and II hypertension, 90.9% had increased carotid intima-media thickness. Nutritional status, body fat and laboratory tests were not associated with increased carotid intima-media thickness. After multivariate adjustment, only puberty (PR = 1.30, p = 0.037) and stages I and II arterial hypertension (PR = 1.42, p = 0.011) were independently associated with carotid intima-media thickness alterations. Conclusion: The prevalence of increased carotid thickness was high in children and adolescents with chronic kidney disease. Puberty and arterial hypertension were independently associated with increased carotid intima-media thickness.


RESUMO Objetivo: Avaliar a espessura médio-intimal da carótida e os fatores associados à doença cardiovascular em crianças e adolescentes com doença renal crônica. Material e métodos: Estudo observacional transversal feito na Universidade Federal de São Paulo (ambulatórios de doença renal crônica) com 55 pacientes (60% do sexo masculino) com mediana de 11,9 anos (I25-I75: 9,2-14,8). Dos 55 pacientes, 43 estavam em tratamento conservador e 12 em terapia dialítica. Foram avaliados os parâmetros laboratoriais séricos (creatinina, ácido úrico, proteína C-reativa, colesterol total e frações e triglicérides), estado nutricional (escore z de índice de massa corpórea, escore z de estatura/idade), gordura corporal (percentual de gordura e circunferência abdominal) e pressão arterial. A medida da espessura médio-intimal da carótida foi avaliada por um único ultrassonografista e comparada com percentis estabelecidos de acordo com o sexo e a estatura. A coleta de dados foi feita entre maio de 2015 e março de 2016. Resultados: Das crianças e adolescentes com doença renal crônica, 74,5% (IC 95%: 61,0; 85,3) apresentaram aumento (> P95) da espessura médio-intimal da carótida. Nos pacientes com hipertensão arterial estágios I e II, 90,9% apresentaram aumento da espessura médio-intimal da carótida. O estado nutricional, a gordura corporal e os exames laboratoriais não apresentaram associação com o aumento da espessura médio-intimal da carótida. Após ajuste multivariado, apenas a puberdade (RP = 1,30; p = 0,037) e a hipertensão arterial estágios I e II (RP = 1,42; p = 0,011) mostraram-se independentemente associados à alteração da espessura médio-intimal da carótida. Conclusão: A prevalência do aumento da espessura da carótida foi elevada em crianças e adolescentes com doença renal crônica. A puberdade e a hipertensão arterial mostraram-se independentemente associadas ao aumento da espessura médio-intimal da carótida.


Subject(s)
Humans , Male , Female , Child , Adolescent , Cardiovascular Diseases/complications , Carotid Arteries/physiopathology , Renal Insufficiency, Chronic/complications , Carotid Intima-Media Thickness , Sexual Maturation , Blood Pressure , Cross-Sectional Studies , Risk Factors , Puberty , Hypertension/complications , Hypertension/physiopathology
4.
Rev. cuba. pediatr ; 91(2): e735, abr.-jun. 2019.
Article in Spanish | LILACS (Americas) | ID: biblio-1042940

ABSTRACT

El reconocimiento inicial de la disfunción cardíaca ocasionada por estrategias terapéuticas aplicadas contra el cáncer fue realizado en la sexta década del siglo xx. La Cardiooncología es una nueva disciplina horizontal dirigida a la identificación de los pacientes en riesgo elevado para el desarrollo de toxicidad cardíaca. El eficaz desempeño inherente a la Cardiooncología pediátrica radica en la adecuada selección del medio diagnóstico capaz de identificar y evaluar los indicios de cardiotoxicidad mediante la detección de cambios precoces en la funcionalidad del miocardio tras la aplicación de terapias antitumorales y, sobre todo, la predicción a largo plazo de estos eventos en niños sobrevivientes de cáncer. La cardiotoxicidad secundaria a la terapéutica aplicada sobre estos pacientes es un problema de salud latente en nuestro país que precisa la adopción de medidas organizativas concebidas para su enfrentamiento. Se persigue contribuir a la estructuración de la atención integral correspondiente al niño con cáncer y afectado por cardiotoxicidad en Cuba(AU)


The initial recognition of cardiac dysfunction caused by therapeutic strategies applied against cancer was performed in the sixth decade of the twentieth century. Cardio-Oncology is a new horizontal discipline aimed at the identification of patients at high risk for the development of cardiac toxicity. The effective performance inherent in Pediatric cardio-oncology lies in the appropriate selection of the diagnostic mean which can be capable of identifying and evaluating the indications of heart toxicity by detecting early changes in myocardial functionality after the application of anti-tumour therapies and, above all, the long-term prediction of these events in children survivors of cancer. Cardiac toxicity secondary to the therapies applied on these patients is a latent health problem in our country that requires the adoption of organisational measures conceived for their confrontation. It is pursued to contribute to the structuring of the comprehensive care corresponding to children with cancer and affected by cardiotoxicity in Cuba(AU)


Subject(s)
Humans , Male , Female , Child , Cardiovascular Diseases/complications , Radiation Oncology/methods , Cardiotoxicity/complications , Cardiotoxicity/prevention & control , Antineoplastic Agents/adverse effects
6.
Int. j. cardiovasc. sci. (Impr.) ; 32(2): 163-176, mar.-abr. 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-988222

ABSTRACT

Acute myocardial infarction (AMI) is less frequent in young individuals (≤ 45 years) than in older ones (> 45 years). Young AMI patients differ from older AMI patients in different ways. This article aims to assess the differences between young and older AMI patients. A search was made in the database of Cochrane Library, PubMed, BioMed Central and Embase, sence their establishment to December 2016, using the key words: risk factors, clinical characteristics, acute myocardial infarction and young. Meta-analysis was performed by using the Review Manager 5.3 software, pooled odds ratios and 95% confidence intervals were used to assess the strength of differences. Eight studies with fairly quality, enrolling 13,358 patients in the analysis. Compared with older AMI patients, young AMI patients had a higher rate of smoking and obesity (OR = 2.71,95%CI:1.87 to 3.92; OR = 1.76,95%CI:1.13 to 2.74), higher rate of family history of coronary artery disease and alcohol consumption (OR = 2.36,95%CI:1.22 to 4.59; OR = 1.76,95%CI:1.04 to 2.97). Moreover, Young AMI patients had a lower rate of hypertension and diabetes mellitus (OR = 0.52,95%CI:0.37 to 0.73; OR = 0.58,95%CI:0.50 to 0.67). No significant differences were observed in hyperlipidemia, a subgroup data-analysis showed a higher total cholesterol, triglyceride lipase, and low-density lipoprotein levels (p < 0.05), and lower levels of high-density lipoprotein (p < 0.01) in young AMI patients. Smoking, family history of coronary artery disease, obesity and alcohol consumption are the most main risk factors of AMI among young individuals, and young AMI patients have better prognosis than older ones


Subject(s)
Humans , Male , Female , Risk Factors , Myocardial Infarction/complications , Myocardial Infarction/mortality , Aged , Alcohol Drinking , Cardiovascular Diseases/complications , Cardiovascular Diseases/mortality , Smoking , Statistical Analysis , Age Factors , Coronary Angiography/methods , Meta-Analysis , Diabetes Mellitus , Young Adult , Hypertension , Obesity
7.
Int. j. cardiovasc. sci. (Impr.) ; 32(2): 163-176, mar.-abr. 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-989991

ABSTRACT

Acute myocardial infarction (AMI) is less frequent in young individuals (≤ 45 years) than in older ones (> 45 years). Young AMI patients differ from older AMI patients in different ways. This article aims to assess the differences between young and older AMI patients. A search was made in the database of Cochrane Library, PubMed, BioMed Central and Embase, sence their establishment to December 2016, using the key words: risk factors, clinical characteristics, acute myocardial infarction and young. Meta-analysis was performed by using the Review Manager 5.3 software, pooled odds ratios and 95% confidence intervals were used to assess the strength of differences. Eight studies with fairly quality, enrolling 13,358 patients in the analysis. Compared with older AMI patients, young AMI patients had a higher rate of smoking and obesity (OR = 2.71,95%CI:1.87 to 3.92; OR = 1.76,95%CI:1.13 to 2.74), higher rate of family history of coronary artery disease and alcohol consumption (OR = 2.36,95%CI:1.22 to 4.59; OR = 1.76,95%CI:1.04 to 2.97). Moreover, Young AMI patients had a lower rate of hypertension and diabetes mellitus (OR = 0.52,95%CI:0.37 to 0.73; OR = 0.58,95%CI:0.50 to 0.67). No significant differences were observed in hyperlipidemia, a subgroup data-analysis showed a higher total cholesterol, triglyceride lipase, and low-density lipoprotein levels (p < 0.05), and lower levels of high-density lipoprotein (p < 0.01) in young AMI patients. Smoking, family history of coronary artery disease, obesity and alcohol consumption are the most main risk factors of AMI among young individuals, and young AMI patients have better prognosis than older ones


Subject(s)
Humans , Male , Female , Aged , Risk Factors , Myocardial Infarction/complications , Myocardial Infarction/mortality , Alcohol Drinking , Cardiovascular Diseases/complications , Cardiovascular Diseases/mortality , Smoking , Statistical Analysis , Age Factors , Coronary Angiography/methods , Meta-Analysis , Diabetes Mellitus , Young Adult , Hyperlipidemias , Hypertension , Obesity
8.
In. Consolim-Colombo, Fernanda M; Saraiva, José Francisco Kerr; Izar, Maria Cristina de Oliveira. Tratado de Cardiologia: SOCESP / Cardiology Treaty: SOCESP. São Paulo, Manole, 4ª; 2019. p.471-477.
Monography in Portuguese | LILACS (Americas) | ID: biblio-1009117
9.
Article in Portuguese | LILACS (Americas) | ID: biblio-998685

ABSTRACT

As doenças cardiovasculares são a principal causa de morte no Brasil. Os fatores de risco modificáveis dessas doenças podem ser observados desde a infância e sua persistência está associada ao diagnóstico precoce de morbidades. Neste contexto, a adolescência é considerada um período chave para estratégias de prevenção. Com objetivo de avaliar a prevalência de fatores de risco cardiovascular e seus fatores as-sociados foi planejado o Estudo de riscos cardiovasculares em adolescentes (ERICA), um inquérito multicêntrico de base escolar com abrangência nacional que envolveu mais de 70 mil adolescentes, entre 12 e 17 anos, de cidades brasileiras com mais de 100 mil habitantes. Os principais resultados do estudo apontaram prevalências preo-cupantes de sobrepeso/obesidade (25,5%, IC 95%: 24,4%-26,6%), pressão arterial elevada (9,6%, IC 95%: 8,9%-10,3%) e HDL-c baixo (47,3%, IC 95%: 45,2%-49,3%). A prevalência de síndrome metabólica foi de 2,6% (IC 95%: 2,3%-2,9%). Além disso, mais da metade dos adolescentes reportaram um estilo de vida sedentário. As estimativas regionais apontaram a região sul como a que tem maiores prevalências de fatores de risco. O ERICA foi um estudo pioneiro no Brasil e os adolescentes que participaram do estudo no Rio de Janeiro, Porto Alegre, Brasília e Fortaleza serão acompanhados em uma nova etapa. Os primeiros resultados do ERICA podem servir de referência para futuras pesquisas sobre riscos cardiovasculares entre adolescentes brasileiros, bem como subsidiar políticas públicas de saúde.


Cardiovascular disease is the leading cause of mortality in Brazil. Modifiable risk factors for this group of diseases can be observed since childhood, and their persisten-ce is associated with the early diagnosis of morbidities. In this context, adolescence is considered a key period for prevention strategies. In order to evaluate the prevalence of cardiovascular risk factors and their associated factors, the Study of Cardiovascular Risks in Adolescents ("ERICA") was planned. This is a multicenter school-based nationwide survey involving more than 70,000 adolescents aged between 12 and 17 years from Brazilian cities with more than 100 thousand inhabitants. The main results of the study indicated concerning prevalence of overweight/obesity (25.5%, 95% CI: 24.4%-26.6%), high blood pressure (9.6%, 95% CI: 8.9%-10.3%) and low HDL-c (47.3%, 95% CI: 45.2%-49.3%). The prevalence of metabolic syndrome was 2.6% (95% CI: 2.3%-2.9%). In addition, more than half of adolescents reported a sedentary lifestyle. Regional estimates pointed to the south as the region with the highest prevalence of risk factors. ERICA was a pioneering study in Brazil and the adolescents who participated in the study in Rio de Janeiro, Porto Alegre, Brasília and Fortaleza will be followed in a new stage. The first results of ERICA can both serve as a reference for future research on cardiovascular risks among Brazilian adolescents and support public health policies.


Subject(s)
Humans , Adolescent , Cardiovascular Diseases/complications , Cardiovascular Diseases/physiopathology , Cardiovascular Diseases/pathology , Metabolic Syndrome/diagnosis , Metabolic Syndrome/genetics , Sedentary Behavior/history
12.
Int. j. cardiovasc. sci. (Impr.) ; 31(5)set.-out. 2018.
Article in English | LILACS (Americas) | ID: biblio-914814

ABSTRACT

With the advent of the antiretroviral therapy (ART), people infected with HIV are experiencing a significant increase in life expectancy. However, as this population ages, the morbidity and mortality due to events not related to HIV infection and/or treatment become increasingly clear. Cardiovascular diseases are among the major causes of death, and, thus, understanding the factors that trigger this situation is necessary. This review article will assess how the intrinsic and extrinsic factors related to HIV, ART and the associated risk factors can aid the epidemiological transition of mortality in this population. Moreover, we will present the studies on the epidemiology and pathogenesis of each clinical condition related to HIV-infected individuals, in addition to introducing the major markers of cardiovascular disease in this population. Finally, we will point the main issues to be addressed by health professionals for an adequate prognosis


Subject(s)
Humans , Male , Female , Acquired Immunodeficiency Syndrome , Antiretroviral Therapy, Highly Active , Cardiovascular Diseases/complications , Cardiovascular Diseases/mortality , HIV , Acute Retroviral Syndrome , Age Factors , Diabetes Mellitus , Dyslipidemias , Hypertension/complications , Metabolic Syndrome , Myocardial Infarction/complications , Myocardial Infarction/mortality , Risk Factors , Sex Factors , Illicit Drugs/adverse effects , Tobacco Use Disorder/complications , Zidovudine/therapeutic use
13.
Rev. pediatr. electrón ; 15(2): 19-25, ago. 2018.
Article in Spanish | LILACS (Americas) | ID: biblio-994556

ABSTRACT

El dolor precordial en pediatría representa un bajo porcentaje del total de consultas, sin embargo genera una alta preocupación tanto en los padres como en el equipo de salud. En general se trata de un proceso benigno y la etiología cardíaca es infrecuente, alcanzando apenas el 1-4%. En el presente trabajo de actualización se revisan las diferentes etiologías, con el propósito de identificar factores que orienten a etiología cardíaca y así derivar al especialista u hospitalizar en forma oportuna si se requiere.


The chest pain in pediatrics represents a low percentage of the total of consultations, nevertheless it generates a high concern both in the parents and in the health team. In general, it is a benign process and the cardiac etiology is infrequent, reaching only 1-4%. In the present update work, the different etiologies are reviewed, in order to identify factors that guide the cardiac etiology and thus refer to the specialist or hospitalize in a timely manner if required.


Subject(s)
Humans , Child , Chest Pain/diagnosis , Chest Pain/etiology , Physical Examination , Chest Pain/therapy , Cardiovascular Diseases/complications
14.
Rev. méd. hondur ; 86(1/2): 18-21, ene-. jul. 2018. graf.
Article in Spanish | LILACS (Americas) | ID: biblio-1007078

ABSTRACT

Antecedentes: La hipertensión arterial es una enfermedad crónica no transmisible altamente prevalente en Honduras. Es un factor de riesgo para enfermedades cardiovasculares, cerebrovasculares y renales. La mortalidad por enfermedades cardiovasculares es del 27% en el país, según la Organización Mundial de la Salud. Objetivo: Determinar el nivel de adherencia al tratamiento farmacológico y no farmacológico, en los pacientes hipertensos que acudieron al centro de salud San Juan de Ojojona, en el primer trimestre del año 2017. Pacientes y métodos: Se utilizó el cuestionario Martin-Bayarre-Grau para estudio del nivel de adherencia al tratamiento antihipertensivo, aplicado mediante entrevistas personales a 66 pacientes seleccionados por muestreo aleatorio simple. Resultados: La mayoría de las personas estudiadas (60%) estaban parcialmente adheridas al tratamiento, el 36.4% totalmente adherido y 3% tenía adherencia nula al tratamiento. Conclusión: La escasa actividad física y no seguir las indicaciones dietéticas inluyen grandemente en la adherencia parcial que tiene la mayoría de la población estudiada...(AU)


Subject(s)
Humans , Male , Female , Cardiovascular Diseases/complications , Treatment Adherence and Compliance , Hypertension/therapy , Antihypertensive Agents/therapeutic use
17.
Rev. cuba. pediatr ; 90(2): 306-312, abr.-jun. 2018. tab
Article in Spanish | LILACS (Americas) | ID: biblio-901490

ABSTRACT

Introducción: una alimentación muy selectiva y poco variada durante la primera infancia, puede modificar seriamente los índices de riesgo cardiovascular, ante lo cual, la detección de la alteración lipídica es de suma importancia para promover e implementar el cambio de hábitos. Caso clínico: se presenta una niña de 6 años con una dieta a base de alimentos industriales, a quien se le realizó un perfil lipídico, por considerar que la alimentación tan limitada que consumía era un factor de riesgo aterogénico. Esto permitió diagnosticar una marcada disminución del HDL-colesterol, hipertrigliceridemia y franca alteración de los índices de riesgo. Discusión: existe una relación directa entre la hipertrigliceridemia y el consumo de azúcares simples, presentes en las golosinas, postres o gaseosas. Además, las grasas saturadas e industriales (trans) son responsables de la disminución del colesterol HDL. Llamó la atención la contundencia que ejerció la alteración del laboratorio, sobre el accionar de los padres. Luego de 6 meses de poner en práctica las indicaciones, los valores y los índices de riesgo se normalizaron. Conclusiones: se destaca la importancia de realizar un perfil lipídico en niños mayores de 2 años cuando se detecta el consumo de una dieta aterogénica, dado que el descenso de colesterol HDL tiene relación directa con la alimentación y el estilo de vida. Un valor inferior a 45 mg/dL es un factor de riesgo que puede ser modificado(AU)


Introduction: a very selective and little varied diet during early childhood can seriously modify the cardiovascular risk indexes, and because of that the detection of lipid alteration is very important to promote and implement the change of habits. Clinical case: a 6-year-old girl was presented with a diet based on industrial foods. A lipid profile was made considering that the very limited diet she consumed was an atherogenic risk factor. This allowed diagnosing a marked decrease in HDL-cholesterol, hypertriglyceridemia and real alteration in the risk indexes. Discussion: there is a direct relation among hypertriglyceridemia and the consumption of simple sugars, which are present in sweets, desserts or sodas. In addition, saturated and industrial (trans) fats are responsible for lowering HDL cholesterol. It was significant the impact of the alteration in the laboratory results in the actions taken by the parents. After 6 months of putting the indications into practice, the values and risk indexes were normalized. Conclusions: it is highlighted the importance of performing a lipid profile in children older than 2 years when the consumption of an atherogenic diet is detected, since the decrease in HDL cholesterol is directly related to diet and lifestyle. A value below 45 mg/dL is a risk factor that can be modified(AU)


Subject(s)
Humans , Female , Child , Dietary Sugars/adverse effects , Dyslipidemias/prevention & control , Cardiovascular Diseases/complications , Cholesterol, HDL/adverse effects , Impacts on Health/prevention & control
18.
Rev. cuba. invest. bioméd ; 37(2): 105-116, abr.-jun. 2018. ilus, tab
Article in Spanish | LILACS (Americas) | ID: biblio-1003931

ABSTRACT

Introducción: el pronóstico del riesgo coronario a partir de la actividad en la artritis reumatoide constituye un problema aún vigente. Objetivos: evaluar la capacidad predictiva de factor reumatoide, proteína C reactiva, C3-C4 complemento, y el índice de actividad de la enfermedad empleándose 28 articulaciones sobre el riesgo coronario en esta enfermedad Métodos: se realizó un estudio longitudinal-prospectivo en una muestra de 50 pacientes. Los niveles séricos de: factor reumatoide, proteína c reactiva, C3, C4 complemento, lipoproteína(a), apolipoproteínas B y A1 fueron determinados por método inmunoturbidimétrico, mientras Colesterol total, colesterol de lioproteína de baja y alta densidad colesterol por ensayo enzimocolorimétrico. La velocidad de sedimentación globular fue determinada por método de Westergreen. El riesgo coronario se definió según valores deseables, o no, de los indicadores: lipoproteína (a), cocientes Apolipoproteína B/Apolipoproteína A1, colesterol de lipoproteína de baja densidad/colesterol de lipoproteína de alta densidad, Apolipoproteína B/colesterol de lipoproteína de baja densidad e índice aterogénico. Se empleó el programa estadístico SPSS, versión 18.0 para el análisis. Resultados: el perfil de actividad inmunoinflamatoria de la captación mostró adecuada capacidad predictiva sobre el riesgo coronario [regresión logística: Test de Hosmer y Lemeshow: (p= 0,54), porciento global de predicción correcta: 64 y 90 por ciento, al primer y tercer mes]. Las variables C3 complemento, C4 complemento e índice de actividad de la enfermedad contribuyeron a la predicción directa del riesgo coronario según cocientes Apolipoproteína B/Apolipoproteína A1, colesterol de lipoproteína de baja densidad/colesterol de lipoproteína de alta densidad e índice aterogénico (p asociada al Odds ratio ≤ 0,05). Los marcadores del metabolismo lipoproteico estudiados, excepto el cociente Apolipoproteína B/colesterol de lipoproteína de baja densidad, correspondientes al mes y tercer mes de seguimiento fueron pronosticados a partir de C4, C3 complemento, índice de actividad de la enfermedad y proteína C reactiva al momento de la captación (regresión lineal: R2 con p asociada ≤ 0,05). El factor reumatoide no contribuyó a la predicción longitudinal del riesgo coronario estudiado. Conclusiones: se demostró la utilidad del perfil de marcadores de actividad de la artritis reumatoide analizados en la predicción del riesgo coronario(AU)


Introduction: the prognosis of coronary risk from the activity in rheumatoid arthritis is still a problem. Objectives: to evaluate the predictive capacity of rheumatoid factor, C-reactive protein, C3-C4 complement, and the activity index of the disease using 28 joints on coronary risk in this disease Methods: a longitudinal-prospective study was carried out in a sample of 50 patients. The serum levels of: rheumatoid factor, c-reactive protein, C3, C4 complement, lipoprotein (a), apolipoproteins B and A1 were determined by immunoturbidimetric method, while total cholesterol, low-density lipoprotein cholesterol and high-density cholesterol by enzyme-correlated assay. The erythrocyte sedimentation rate was determined by the Westergreen method. Coronary risk was defined according to desirable values, or not, of the indicators: lipoprotein (a), Apolipoprotein B / Apolipoprotein A1 ratios, low density lipoprotein cholesterol / high density lipoprotein cholesterol, Apolipoprotein B / low lipoprotein cholesterol density and atherogenic index. The statistical program SPSS, version 18.0 was used for the analysis. Results: the profile of immunoinflammatory activity of the uptake showed adequate predictive capacity on coronary risk [logistic regression: Hosmer and Lemeshow test: (p = 0.54), overall percentage of correct prediction: 64 and 90 percent, to the first and third month]. The variables C3 complement, C4 complement and index of disease activity contributed to the direct prediction of coronary risk according to the Apolipoprotein B / Apolipoprotein A1, low density lipoprotein cholesterol / high density lipoprotein cholesterol and atherogenic index (p associated with Odds ratio ≤ 0.05). The lipoprotein metabolism markers studied, except for the Apolipoprotein B / low density lipoprotein cholesterol ratio, corresponding to the month and third month of follow-up were predicted from C4, C3 complement, disease activity index and C-reactive protein at the time of the uptake (linear regression: R2 with associated p≤0.05). The rheumatoid factor did not contribute to the longitudinal prediction of coronary risk studied. Conclusions: the usefulness of the profile of activity markers of rheumatoid arthritis analyzed in the prediction of coronary risk was demonstrated(AU)


Subject(s)
Humans , Male , Female , Arthritis, Rheumatoid/immunology , Rheumatoid Factor/immunology , Rheumatoid Factor/therapeutic use , Cardiovascular Diseases/complications , Predictive Value of Tests , Prospective Studies , Longitudinal Studies , Sickness Impact Profile , Health Risk
19.
J. bras. nefrol ; 40(2): 179-192, Apr.-June 2018. tab, graf
Article in English | LILACS (Americas) | ID: biblio-954538

ABSTRACT

ABSTRACT Cardiovascular disease (CVD) is one of the leading causes of mortality in hemodialysis (HD) subjects. In addition to the traditional risk factors that are common in these individuals, genetic factors are also involved, with emphasis on single nucleotide polymorphs (SNPs). In this context, the present study aims to systematically review the studies that investigated the polymorphisms associated with cardiovascular risk in this population. In general, the SNPs present in HD individuals are those of genes related to inflammation, oxidative stress and vascular calcification, also able of interfering in the cardiovascular risk of this population. In addition, polymorphisms in genes related to recognized risk factors for CVD, such as dyslipidemia, arterial hypertension and left ventricular hypertrophy, also influence cardiovascular morbidity and mortality.


RESUMO A doença cardiovascular (DCV) é uma das principais causas de mortalidade de indivíduos em hemodiálise (HD). Além dos fatores de risco tradicionais, que são frequentes nesses indivíduos, também estão envolvidos fatores genéticos, com destaque para os polimorfismos de nucleotídeo único (do inglês, single nucleotide polymorphism, SNP). O presente trabalho tem como objetivo revisar sistematicamente os estudos que investigaram os polimorfismos associados ao risco cardiovascular nessa população. De modo geral, os SNPs presentes em indivíduos em HD são aqueles de genes relacionados à inflamação, estresse oxidativo e calcificação vascular, também capazes de interferir no risco cardiovascular dos pacientes. Polimorfismos em genes relacionados a fatores de risco reconhecidos para DCV, como dislipidemia, hipertensão arterial e hipertrofia ventricular esquerda, também influenciam a morbidade e mortalidade cardiovascular.


Subject(s)
Humans , Cardiovascular Diseases/genetics , Renal Dialysis , Polymorphism, Single Nucleotide , Kidney Failure, Chronic/genetics , Kidney Failure, Chronic/therapy , Cardiovascular Diseases/complications , Risk Factors , Kidney Failure, Chronic/complications
20.
Rev. habanera cienc. méd ; 17(2): 225-235, mar.-abr. 2018.
Article in Spanish | LILACS (Americas) | ID: biblio-960881

ABSTRACT

Introducción: El tabaquismo es un grave problema de salud mundial debido a los daños asociados a su consumo. Es la causa que más influye en la morbilidad y mortalidad por enfermedades crónicas no transmisibles. Se encuentra relacionado con el desarrollo de enfermedades cardiovasculares. Objetivo: Describir las afectaciones provocadas por el tabaquismo en el sistema cardiovascular. Material y Métodos: Se realizó una revisión bibliográfica empleando literatura nacional e internacional, en formato electrónico e impreso. Se expresaron criterios de autores y resultados de investigaciones disponibles en las bases de datos SciELO, Medline, PubMED y Google. Se emplearon un total de 26 referencias bibliográficas. Los criterios de selección establecieron un período de 5 años hasta la actualidad, utilizando además literaturas anteriores de valor para esta investigación. Desarrollo: La nicotina es el principal componente del tabaco que ejerce un poder adictivo.Fumar tiene un efecto sinérgico con la presencia de otros factores de riesgo aumentando el riesgo cardiovascular total. La probabilidad de desarrollar afectaciones cardiovasculares en fumadores se relaciona directamente con el número de cigarrillos consumidos diariamente y el tiempo de evolución. Conclusiones: El tabaquismo constituye una mala conducta social y un peligroso factor de riesgo, representando la principal causa de mortalidad y morbilidad cardiovascular posible de prevenir en el mundo(AU)


Introduction: Smoking is a serious global health problem due to the damages associated with its consumption. It is the cause that most influences morbidity and mortality due to chronic non-communicable diseases. It is related to the development of cardiovascular diseases. Objective: To describe the affectations of the cardiovascular system caused by smoking. Material and Methods: A bibliographic review was made using national and international literature, in both electronic and printed formats. Authors' criteria and research results available from SciELO, Medline, PubMED and Google databases were expressed. A total of 26 bibliographical references were used. Selection criteria established a period of 5 years to date, also using previous literature of great value for this research. Development: Nicotine is the main component of tobacco that exerts an addictive power. Smoking has a synergistic effect on other health related risk factors, thus increasing the total cardiovascular risk. The probability of developing cardiovascular affectations in smokers is directly related to the number of cigarettes consumed daily and the time of evolution. Conclusions: Smoking constitutes a bad social behavior and a dangerous risk factor, representing the main cause of mortality and cardiovascular morbidity that can be prevented in the world(AU)


Subject(s)
Humans , Male , Female , Tobacco Use Disorder/complications , Cardiovascular Diseases/complications , Tobacco Use Disorder/prevention & control , Risk Factors
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