Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 801
Filter
1.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 622-628, jan.-dez. 2020. tab, ilus
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-1097374

ABSTRACT

Objetivo: analisar o custo da utilização do cateter venoso central de duplo versus triplo lúmen em uma unidade de terapia intensiva. Métodos: estudo de custo-minimização, com abordagem quantitativa à luz da avaliação econômica de saúde. Foram analisados custos e a ocorrência de eventos adversos em uma amostra com 30 cateter venoso central. A coleta de dados foi através de um check list com dados do prontuário. Os dados foram tabulados e analisados a partir da árvore de decisão através do software Tree Age®. Resultados: o cateter venoso central triplo lúmen teve um custo relacionado a eventos adversos de R$ 7.648,22 apresentando-se superior ao duplo lúmen. Conclusão: a quantidade de lúmens está relacionada a maior ocorrência de eventos adversos e a um maior custo. Dessa forma, contribui com a enfermagem por direcionar a aplicação de recursos financeiros e orientar estratégias para minimizar a ocorrência de eventos adversos


Objective: to analyze or use central venous catheter of double versus triple lumen in an intensive care unit. Methods: study of custominimization, with quantitative approach to light of the economic avaluation of saúde. Foram analyzed custos e a oocorrência adverse events in amostra com 30 central venous catheter. A data queue is made through a checklist with data on the prognosis. The data are tabulated and analyzed from the decision tree through Tree Age® software. Results: central venous catheter triplo lúmen teve um custo related to adverse events of R$ 7,648.22 apresentando-se superior ao duplo lúmen. Conclusion: a quantum of lumens is related to a higher incidence of adverse events and a higher custody. In this way, I contributed to nursing by directing theapplication of financial resources and orienting strategies to minimize the occurrence of adverse events


Objetivo: análisis de la utilización del catéter venoso central de duplex versus triplo lúmen in uma unidade de terapia intensiva. Métodos: estudio de minimización, análisis cuantitativo de la luz económica de la economía. Otros analisados guardan y una situación de eventos adversos en la amostra com 30 cateter venoso central. Una coleta de dados para através de una lista de verificación con los datos del programa. Los datos de las tablas y los análisis a partir del momento de la decisión del software Tree Age®. Resultados: o cateter venoso central lúmen teve um custo relacionado a eventos adversos de R$ 7.648,22 apresentando-se superior ao duplo lúmen. Conclusión: a quantidade de lúmens está relacionada con una mayor ocorrência de eventos adversos e um mayor custo. Dessa forma, contribui com a enfermagem por direcionar a la aplicación de recursos financieros y orientaciones estratégicas para minimizar la ocorrência de eventos adversos


Subject(s)
Humans , Catheterization, Central Venous , Costs and Cost Analysis , Intensive Care Units , Nursing Care
2.
Rev Rene (Online) ; 21: e42980, 2020. tab
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1101376

ABSTRACT

RESUMO Objetivo avaliar a progressão do cateter central de inserção periférica em região hemiclavicular direita, através da veia basílica e cefálica direita, em recém-nascidos. Métodos pesquisa quase experimental, realizada em unidade neonatal. Amostra de 64 inserções de cateteres, em 58 recém-nascidos. A intervenção consistiu em manobra de elevação, protração e abaixamento do ombro, aplicada após não progressão do cateter, em região hemiclavicular, na punção direta em região cubital, em veia basílica ou cefálica direita. Resultados das 64 inserções, progrediram sem manobra 28(43,7%); em mais da metade, aplicou-se manobra, obtendo-se 28(77,8%) progressões, sendo que 15(41,7%) progrediram após elevação, 12(57,1%) após protração e 1(11,1%) abaixamento do ombro, destes que progrediram, 21(75%) estavam em posição central. Verificou-se significância estatística (p<0,05) entre progressão com manobra e veia cefálica, progressão sem manobra e veia basílica. Conclusão a intervenção facilitou progressão do cateter, principalmente por veia cefálica.


ABSTRACT Objective to evaluate the progression of the peripherally inserted central catheter in the right hemiclavicular region, through the right basilic and cephalic vein, in newborns. Methods quasi-experimental research, carried out in a neonatal unit. Sample of 64 catheter insertions in 58 newborns. The intervention consisted of shoulder elevation, protraction and lowering maneuver, applied after the catheter had not progressed, in the hemiclavicular region by direct puncture in the cubital region, in the right basilic or cephalic vein. Results of the 64 insertions, 28(43.7%) progressed without maneuver; in more than half, a maneuver was applied, obtaining 28(77.8%) progressions, with 15(41.7%) progressing after elevation, 12(57.1%) after protraction, 1(11.1%) lowering the shoulder, of those that progressed, 21(75%) were in central position. There was statistical significance (p<0.05) between progression with maneuver and cephalic vein, progression without maneuver and basilic vein. Conclusion the intervention facilitated the progression of the catheter, mainly through the cephalic vein.


Subject(s)
Infusions, Intravenous , Infant, Newborn , Catheterization, Central Venous , Catheterization, Peripheral , Neonatal Nursing
3.
Rev. enferm. UERJ ; 27: e44521, jan.-dez. 2019. tab
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1053550

ABSTRACT

Objetivo: identificar as necessidades humanas básicas alteradas nos neonatos com cateter central de inserção periférica em Unidade de Terapia Intensiva Neonatal, à luz da Teoria das Necessidades Humanas Básicas. Método: estudo transversal de abordagem quantitativa, realizado com 108 recém-nascidos em uma maternidade do Nordeste brasileiro entre os meses de fevereiro e dezembro de 2017. O instrumento de coleta de dados utilizado foi um roteiro de anamnese e exame físico. Os resultados foram analisados por meio da Teoria de Wanda Horta. Resultados: foram identificadas dez necessidades alteradas, com destaque para as mais prevalentes: integridade cutâneo-mucosa, ambiente, nutrição, hidratação, oxigenação e atenção. Conclusão: a identificação das necessidades humanas básicas alteradas nos neonatos com cateter central de inserção periférica pode subsidiar a elaboração de um plano de cuidados baseado em evidências e direcionado para essa população.


Objective: to identify the changed basic human needs in neonates with peripherally inserted central catheter, in light of the Theory of Basic Human Needs. Method: cross-sectional study, conducted with 108 newborns in a maternity hospital in the Northeast of Brazil between February and December 2017. An anamnesis and physical examination script was used for data collection. The results were analyzed using the Wanda Horta Theory. Results: ten altered needs were identified, highlighting the most prevalent ones: mucosal skin integrity, environment, nutrition, hydration, oxygenation and attention. Conclusion: the identification of altered basic human needs in neonates with peripherally inserted central catheter may support the elaboration of a care plan based on scientific evidences and directed to this population..


Objetivo: identificar las necesidades humanas básicas alteradas en recién nacidos con catéteres centrales insertados periféricamente en una Unidad de Cuidados Intensivos Neonatales, a la luz de la Teoría de las Necesidades Humanas Básicas. Método: estudio de enfoque cuantitativo, transversal, realizado con 108 recién nacidos en una maternidad en el nordeste de Brasil entre febrero y diciembre de 2017. El instrumento de recolección de datos utilizado fue un guión de historia y examen físico. Los resultados se analizaron utilizando la teoría de Wanda Horta. Resultados: se identificaron diez necesidades alteradas, destacando las más frecuentes: integridad de la piel, medio ambiente, nutrición, hidratación, oxigenación y atención. Conclusión: la identificación de necesidades humanas básicas alteradas en neonatos con catéter central insertado periféricamente puede apoyar la elaboración de un plan de atención basado en evidencias científicas y dirigido a esta población.


Subject(s)
Humans , Male , Female , Infant, Newborn , Nursing Theory , Infant, Newborn , Catheterization, Central Venous , Catheterization, Peripheral/nursing , Intensive Care Units, Neonatal , Nursing Process , Catheterization, Peripheral , Cross-Sectional Studies , Parenteral Nutrition , Nursing Care
4.
J. bras. econ. saúde (Impr.) ; 11(2): 112-118, Agosto/2019.
Article in Portuguese | LILACS (Americas), ECOS | ID: biblio-1021040

ABSTRACT

Objetivo: Determinar a factibilidade econômica da técnica de cateterismo central em veia jugular interna guiada pelo ultrassom comparado à técnica-padrão, sob a perspectiva pagadora do Sistema Único de Saúde brasileiro. Métodos: Análise de custo-efetividade utilizando modelo de árvore de decisão sob uma população de pacientes adultos em um cenário de uma unidade terciária. Os custos diretos dos materiais e procedimentos foram estimados utilizando bancos de registros de compras nacionais. Os desfechos foram a ocorrência ou não da punção arterial acidental grave (principal complicação associada ao sítio de punção). Também foram conduzidas análises de sensibilidade determinística e probabilística, bem como curva de aceitabilidade. Resultados: A intervenção onerou o modelo em R$ 53,81. A razão de custo-efetividade incremental calculada foi de R$ 17.936,66 por complicação grave evitada e a curva de aceitabilidade evidenciou que a técnica é custo-efetiva sob uma intenção de pagar de R$ 18.125,00. Na análise de sensibilidade probabilística, 63,6% das simulações mostraram-se custo-efetivas. Conclusão: A intervenção é custo-efetiva, contribuindo para a redução das complicações graves, e o resultado pode proporcionar segurança para tomadas de decisões quanto à padronização do uso da ultrassonografia como orientador do procedimento.


Objective: To determine the economic feasibility of the central catheterization technique in the internal jugular vein guided by the ultrasound compared to the standard technique, under the perspective of the Brazilian Unified Health System. Methods: Cost-effectiveness analysis using decision tree model under a population of adult patients in a tertiary unit scenario. The direct costs of the materials and procedures were estimated using banks of national procurement records. The outcomes were the occurrence or not of severe accidental arterial puncture (the main complication associated with the puncture site). Analyzes of deterministic and probabilistic sensitivity were also conducted, as well as acceptability curve. Results: The intervention cost the model in R$ 53.81. The calculated incremental cost-effectiveness ratio was R$ 17,936.66 due to a serious complication avoided and the acceptability curve showed that the technique is cost-effective under an intention to pay R$ 18,125.00. In the probabilistic sensitivity analysis, 63.6% of the simulations were cost-effective. Conclusion: The intervention is cost-effective, contributing to the reduction of severe complications and the result can provide security for decision making regarding the standardization of the use of ultrasonography as a guideline of the procedure


Subject(s)
Humans , Catheterization, Central Venous , Ultrasonography, Interventional , Cost-Effectiveness Evaluation , Jugular Veins
5.
J. bras. nefrol ; 41(1): 89-94, Jan.-Mar. 2019. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1002420

ABSTRACT

Abstract Introduction: Vascular access (VA) in hemodialysis (HD) is essential to end-stage renal disease (ESRD) patients survival. Unfortunately, after some years in HD program, a significant number of patients may develop VA failure for many reasons. In this situation, arterial venous fistula (AVF) confection or catheters placement in traditional vascular sites (jugular, femoral or subclavian) are not feasible. In this scenario, translumbar tunneled dialysis catheter (TLDC) may be a salvage option. Objectives: To describe placement technic, complications, and patency of 12 TLDC. Methods: A retrospective study was performed to analyze 12 TLDC placement in an angiography suite using fluoroscopic guidance at the University Hospital of the Rio Grande do Norte Federal University from January 2016 to October 2017. The data collected of the total procedures performed consisted of demographic characteristics, success rates, observed complications, patient survival, and catheter patency. Results: All 12 TLDC were placed with success; there were only 2 significant periprocedure complications (major bleeding and extubation failure); 41.6% of patients presented a catheter-related first infection after 98 ± 72.1 (6-201) days, but catheter withdrawal was not necessary, mean total access patency was 315.5 (range 65 - 631) catheter-days, and catheter patency at 3, 6 and 12 months was 91 %, 75%, and 45%. Conclusion: TLDC is an option for patients with VA failure, improving survival and acting as a bridge for renal transplantation.


Resumo Introdução: O acesso vascular (AV) para hemodiálise (HD) é crucial para os pacientes portadores de doença renal crônica (DRC) estágio V. Infelizmente, com o passar dos anos, um percentual não desprezível desses enfermos evolui para falência de AV por diversos motivos, o que impossibilita a confecção de novas fístulas arteriovenosas (FAV) ou o implante de cateteres venosos centrais nos sítios de punções tradicionais. Nesse cenário, o implante de cateteres translombares para hemodiálise (CTLHD) em veia cava inferior ganha destaque como medida salvadora. Objetivos: Relatar uma série de 12 casos de implante de CTLHD, sua técnica de implante, patência e complicações. Métodos: Estudo retrospectivo que analisou 12 implantes de CTLHD por radiologista intervencionista no setor de hemodinâmica do Hospital Universitário da Universidade Federal do Rio Grande do Norte (UFRN), no período de janeiro/2016 a outubro/2017. Os dados coletados consistiram em: características demográficas da população estudada, taxa de sucesso, complicações observadas, sobrevida dos pacientes, patência do cateter e desfechos clínicos. Resultados: Todos os 12 CTLHD foram implantados e utilizados com sucesso; ocorreram apenas 2 complicações associadas ao procedimento (sangramento e falha na extubação); 41,6% dos pacientes apresentaram infecção relacionada ao cateter após 98 ± 72,1 dias (6-201 dias), mas não houve necessidade de remoção; e a patência foi de 315,5 cateteres-dia (65-631 dias). Conclusão: O CTLHD é uma opção para pacientes com falência de acesso vascular, prolongando a sobrevida dos pacientes e atuando como ponte para o transplante renal.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Vascular Diseases/etiology , Vena Cava, Inferior/surgery , Catheterization, Central Venous/methods , Catheters, Indwelling/adverse effects , Renal Dialysis , Central Venous Catheters/adverse effects , Kidney Failure, Chronic/therapy , Lumbosacral Region/blood supply , Fluoroscopy , Feasibility Studies , Retrospective Studies , Arteriovenous Fistula/complications , Kidney Transplantation , Treatment Outcome , Hemorrhage/etiology
7.
Article in Chinese | WPRIM (Western Pacific) | ID: wprim-813014

ABSTRACT

Central venous catheter (CVC) placement is an operation which can establish a fast, safe, and effective deep venous access to rescue patients under critical conditions, especially for those receiving hemodialysis. It is a simple operation with almost no complications, but different complications have been still reported, such as bleeding, infection, embolism, low blood flow, and cardiac arrhythmias. In this case, the patient with preexisting left bundle branch block suffered right bundle branch block, leading to complete heart block during CVC placement. When the patient developed complete heart block, we immediately treated him with isoproterenol, and the surgery was terminated as soon as possible. The patient gradually recovered the sinus rhythm after the treatment. This complication is rare but severe, and clinicians should recognize the risks and take strategies as early as possible. We think the cause of complete heart block in this patient may be related to mechanical trauma to the right ventricle by the guide wire or catheter insertion. Therefore, CVC placement should be performed with more caution, and the guide wire and catheter tip should be inserted less than 18 cm deep.


Subject(s)
Arrhythmias, Cardiac , Catheterization, Central Venous , Central Venous Catheters , Heart Block , Humans , Male , Renal Dialysis
8.
Article in Chinese | WPRIM (Western Pacific) | ID: wprim-781718

ABSTRACT

OBJECTIVE@#To investigate the effect of placement of peripherally inserted central catheter (PICC) via the upper versus lower extremity veins in neonates through a Meta analysis.@*METHODS@#CNKI, Wanfang Data, VIP Data, CBMdisc, PubMed, Web of Knowledge, Embase, Medline, Cochrane Library and Google Scholar were searched for control studies on the effect of PICC placement via the upper versus lower extremity veins in neonates. RevMan 5.3 was used to perform a Meta analysis of the studies which met the inclusion criteria.@*RESULTS@#A total of 18 studies were included, among which there were 8 randomized controlled trials and 10 cohort studies, with 4 890 subjects in total. Compared with those undergoing PICC placement via the upper extremity veins, the neonates undergoing PICC placement via the lower extremity veins had significantly lower incidence rates of complications (RR=0.83, 95%CI: 0.75-0.92, P<0.05), catheter-related infections (RR=0.77, 95%CI: 0.60-0.99, P<0.05), catheter malposition (RR=0.28, 95%CI: 0.18-0.42, P<0.05), extravasation of the infusate (RR=0.52, 95%CI: 0.40-0.70, P<0.05), and unplanned extubation (RR=0.82, 95%CI: 0.69-0.98, P<0.05). They also had a significantly higher first-attempt success rate of puncture (RR=1.17, 95%CI: 1.05-1.30, P<0.05) and a significantly shorter PICC indwelling time (MD=-0.93, 95%CI: -1.26-0.60, P<0.05).@*CONCLUSIONS@#The above evidence shows that PICC placement via the lower extremity veins has a better effect than PICC placement via the upper extremity veins in neonates.


Subject(s)
Catheterization, Central Venous , Catheterization, Peripheral , Cohort Studies , Humans , Infant, Newborn , Lower Extremity , Retrospective Studies
9.
Article in Chinese | WPRIM (Western Pacific) | ID: wprim-774324

ABSTRACT

OBJECTIVE@#To evaluate the effects of peripheral introvascular central catheters (PICC) on the catheter-associated bloodstream infections (CRBSI) and the formations of catheter-related bloodstream infections.@*METHODS@#Total of 483 patients with hematologic malignancies admitted in our hospital from January 2013 to December 2016 were enrolled in this study, and 612 PICC catheterization were conducted. The median time of catheterization was 101 d (48 ∼ 184 d) . The incidence rates of CRBSI and CRTC were observed, and the CRBSI and CRTC associated variables were also analyzed.@*RESULTS@#There were 47 cases of CRBSI (7.7%), and the incidence was 0.59‰ PICC days, and there were 16 cases of CRTC (2.6%), with the incidence of 0.20‰ PICC days. Meanwhile, no other related serious complications found. The Cox regression analysis of CRBSI and CRTC-associated variables showed that the acute leukemia was significantly related with a higher incidence of CRBSI as compared with the other type of disease, however, which was not significantly related with the CRTC.@*CONCLUSION@#Compared with the traditional CVAD catheterization, the PICC is more safe and effective for the patients with malignant tumors, thus which may become a alternative method for CVAD.


Subject(s)
Catheter-Related Infections , Catheterization, Central Venous , Hematologic Diseases , Humans , Incidence , Risk Factors , Thrombosis
10.
Rev. pesqui. cuid. fundam. (Online) ; 11(2, n. esp): 278-284, jan. 2019. tab
Article in English, Portuguese | LILACS (Americas), BDENF | ID: biblio-969281

ABSTRACT

Objective: Th study's purpose has been to assess nursing practices regarding the insertion, maintenance and removal of Peripherally Inserted Central Catheter in neonates. Methods: It is a retrospective study that was carried out in a University Hospital with a sample of 137 newborns over the period from 2009 to 2012. Data were collected from medical records and analyzed with statistical tests. Results: Th initial positioning of the tip of the catheter was central in 60.6%. Thre were complications in 53.3% of catheters, and the most common of those were as follows: obstruction (13.1%), infitration and/or overflw (12.4%). Th catheter's permanence time was inflenced (p<0.05) by the non-central positioning of the tip, complications, and the nonelective removal. Conclusion: It is important to highlight the need for creating both protocols and educative intervention programs in order to guarantee the patient's safety, and also the assistance quality


Objetivo: Avaliar as práticas de enfermagem na inserção, manutenção e remoção do Cateter Central de Inserção Periférica em neonatos. Métodos: Estudo correlacional retrospectivo realizado em um Hospital Universitário com amostra de 137 neonatos no período de 2009 a 2012. Os dados foram coletados no prontuário e analisados com testes estatísticos. Resultados: O posicionamento inicial da ponta do cateter foi central em 60,6%. Complicações ocorreram em 53,3% dos cateteres, e as mais comuns: obstrução (13,1%) e infitração/extravasamento (12,4%). O tempo de permanência foi inflenciado (p<0,05) pela posição da ponta não central, complicações e remoção não eletiva. Conclusão: Destaca-se a necessidade de elaboração de protocolos e a realização de programas de intervenção educativa, a fim de garantir a segurança do paciente e a qualidade da assistência


Objetivo: Evaluar las prácticas de enfermería en la inserción, mantenimiento y retirada de catéter central de inserción periférica en los recién nacidos. Métodos: Estudio correlacional retrospectivo realizado en un hospital universitario con una muestra de 137 recién nacidos en el período de 2009 a 2012. Los datos fueron recogidos de las historias clínicas y se analizaron con pruebas estadísticas. Resultados: La colocación inicial de la punta del catéter fue central en el 60,6%. Las complicaciones ocurrieron en el 53,3%, y las más comunes: obstrucción (13,1%) y la infitración/extravasación (12,4%). El tiempo de permanencia fue inflenciado (p <0,05) por posición de la punta no central, las complicaciones y la eliminación no electiva. Conclusión: Se destacó la necesidad de desarrollo de protocolos y la realización de un programa de intervención educativa con el fi de garantizar la seguridad del paciente y la calidad de la atención


Subject(s)
Humans , Male , Female , Infant, Newborn , Catheterization, Central Venous/nursing , Catheterization, Peripheral/nursing , Intensive Care Units, Neonatal
11.
Cogitare enferm ; 24: e55639, 2019. tab, graf
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1019731

ABSTRACT

RESUMO Objetivo analisar o perfil do processo de implantação do Cateter Central de Inserção Periférica, por enfermeiros capacitados, em adolescentes atendidos em um Hospital Universitário do Rio de Janeiro. Método estudo documental, descritivo, retrospectivo, de abordagem quantitativa, realizado entre janeiro de 2007 e dezembro de 2015. A amostra constituiu-se de 68 prontuários de adolescentes. Foram selecionados prontuários de adolescentes de 12 a 18 anos disponíveis no serviço de arquivo médico e que continham informações acerca do processo de implantação do cateter, e excluídos os dos pacientes que foram transferidos e não retiraram o cateter na instituição. Resultados constatou-se que 48 dos cateteres foram implantados em adolescentes do sexo masculino como diagnóstico médico doença onco-hematológica tendo como indicação terapêutica predominante a quimioterapia. Conclusão O estudo contribuiu para a ampliação do conhecimento sobre o uso deste cateter, além de proporcionar subsídios para a realização de pesquisas e capacitação profissional.


RESUMEN Objetivo evaluar el perfil del proceso de implantación del Catéter Central de Inserción Periférica, por enfermeros habilitados, en adolescentes atendidos en un Hospital Universitario de Rio de Janeiro. Método estudio documental, descriptivo, retrospectivo, de abordaje cuantitativo, que se realizó entre enero de 2007 y diciembre de 2015. La muestra se constituyó de 68 prontuarios de adolescentes. Se seleccionaron prontuarios de adolescentes de 12 a 18 años disponibles en el servicio de archivo médico, los cuales contenían informaciones acerca del proceso de implantación del catéter; fueron excluidos los de los pacientes que se desplazaron y no quitaron el catéter en el hospital. Resultados se constató que 48 de los catéteres fueron implantados en adolescentes del sexo masculino como diagnóstico médico de enfermedad onco hematológica que tuvieron como indicación terapéutica predominante la quimioterapia. Conclusión el estudio contribuyó para la ampliación del conocimiento sobre el uso del catéter, además de proporcionar subsidios para la realización de investigaciones y perfeccionamiento profesional.


ABSTRACT Objective To analyze the profile of peripherally inserted central catheters placement in adolescents admitted to a University Hospital of Rio de Janeiro by trained nurses. Method Documentary, descriptive, retrospective and quantitative study conducted between January 2007 and December 2015. The sample consisted of 68 medical records of adolescents. Medical records of adolescents aged 12-18 years available from the medical archive service and containing information about the process of placement of PICC catheters. The medical records of the patients transferred to other health centers and whose catheters were not removed in the institution were excluded. Results Of all the catheters inserted, 48 were placed in male adolescents diagnosed with onco-hematological disease, and chemotherapy was the predominant therapeutic indication. Conclusion The present study contributed to improve the knowledge about the use of this type of catheter, which will be useful in future studies and in professional training.


Subject(s)
Humans , Catheterization, Central Venous , Adolescent , Catheterization, Peripheral , Nursing
12.
Rev Rene (Online) ; 20: e41279, 2019. tab
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1040988

ABSTRACT

Objetivo analisar a utilização do cateter central de inserção periférica em neonatos. Métodos estudo retrospectivo, documental. Para coleta de dados, utilizou-se de instrumento para registro e acompanhamento de cateter central de inserção periférica. Análise realizada por meio de estatísticas descritivas para obtenção de frequências absolutas, relativas, valores mínimos e máximos, desvios-padrão e médias e teste de qui-quadrado para k-proporções para variáveis qualitativas. Resultados foram analisados 383 registros. O cateter foi indicado, principalmente, para administração de antibioticoterapia (46,5%). O vaso mais acessado foi a veia cefálica (23,5%). A complicação mais incidente foi de progressão (6,8%), com prevalência de remoção por término de tratamento/indicação (25,3%). Conclusão cateter utilizado, principalmente, para administração de antibioticoterapia; veia cefálica mais acessada, com uso de Fentanil para atenuar dor e desconforto; progressão, complicação mais incidente; e maior índice de remoção por término de tratamento/indicação.


Objective to analyze the use of the central catheter for peripheral insertion in newborns. Methods retrospective, documentary study. For data collection, we used an instrument to record and follow the central catheter for peripheral insertion. Analysis performed using descriptive statistics to obtain absolute, relative, minimum and maximum values, standard and mean deviations, and chi-square test for K-proportions for qualitative variables. Results we analyzed 383 records. The catheter was mainly indicated for administration of antibiotic therapy (46.5%). The most accessed vessel was the cephalic vein (23.5%). The most frequent complication was progression (6.8%), with prevalence of removal due to end of treatment/indication (25.3%). Conclusion catheter used mainly for antibiotic therapy administration; cephalic vein mostly accessed, using fentanyl to mitigate pain and discomfort; progression, mostly incident complication; and higher removal rate due to end of treatment/indication.


Subject(s)
Catheterization, Central Venous , Catheterization, Peripheral , Neonatal Nursing , Intensive Care Units , Nursing Care
13.
Revista Digital de Postgrado ; 8(3): e165, 2019. tab
Article in Spanish | LILACS (Americas), LIVECS | ID: biblio-1049952

ABSTRACT

La inserción del catéter venoso central (CVC) ha significado un gran avance en la medicina moderna y su uso generalizado ha permitido el desarrollo de nuevas técnicas diagnósticas y tratamientos especializados. En este estudio se dan a conocer las indicaciones presentes al momento de colocar el catéter venoso central y el tiempo de colocación en los pacientes. Métodos: La investigación fue de tipo retrospectivo, descriptivo y de corte transversal, con un diseño de investigación no experimental y tuvo la finalidad de conocer, en forma directa, la realidad de la problemática. Las unidades de observación fueron(188) historias clínicas de los pacientes que ingresaron en el servicio de medicina interna en el hospital Miguel Pérez Carreño en el periodo comprendido entre enero y abril de 2017. Resultados: El 68% de la indicación del catéter venoso central es para la medición de la presión venosa central (PVC) y control de líquidos, mientras que en el 32% la indicación fue por administración de fármacos. El tiempo de colocación tuvo un predominio del 61% de los pacientes que utilizaron el catéter venoso central durante 1 a 3 semanas, en segundo lugar, el 36% utilizo el catéter por unos días, solo un 3% amerito el uso del catéter venoso central durante 1 mes. Conclusiones: La mayoría de los pacientes estudiados tuvieron como principal indicación de CVC para control de líquido y medición de presión venosa central. Con una duración de 1 a 3 semanas(AU)


The insertion of the central venous catheter (CVC) has meant a great advance in modern medicine and its widespread use has allowed the development of new diagnostic techniques and specialized treatments. In this study we present the indications present at the moment of placing the central venous catheter and the time of use in patients. Methods: The research was of a retrospective, descriptive and cross-sectional type, with a non-experimental research design and aimed to know, in a direct way, the reality of the problem. The units of observation were (188) clinical records of patients admitted to the internal medicine service in the hospital Miguel Pérez Carreño in the period between January and April 2017. Results: 68% of the indication of the central venous catheter is for the measurement of central venous pressure (CVP) and fluid control, while in 32% the indication was for drug administration. The time of use had a predominance of 61% of patients who used the central venous catheter for 1 to 3 weeks, secondly, 36% used the catheter for a few days, only 3% required the use of the central venous catheter for 1 month. Conclusions: The majority of patients studied had CVC as main indication for fluid control and central venous pressure measurement. With a duration of 1 to 3 weeks(AU)


Subject(s)
Humans , Male , Female , Adolescent , Catheterization, Central Venous/methods , Central Venous Pressure , Time Management/methods , Catheter-Related Infections/microbiology , Central Venous Catheters/adverse effects , Medical Records/statistics & numerical data , Retrospective Studies , Vascular Access Devices , Hospitalization
14.
Revista Digital de Postgrado ; 8(3): e167, 2019. graf
Article in Spanish | LILACS (Americas), LIVECS | ID: biblio-1087875

ABSTRACT

La utilización de catéter venoso central produce, en ocasiones, infecciones de tipo local o sistémico, como la bacteriemia no complicada o complicada (bacteriemia persistente, tromboflebitis séptica, endocarditis y otras complicaciones metastásicas). En este estudio se dan a conocer las infecciones ocasionadas por el uso de Catéter Venoso Central (CVC), así como los microorganismos presentes en los pacientes. Métodos: La investigación fue de tipo retrospectivo, descriptivo y de corte transversal, con un diseño de investigación no experimental y tuvo la finalidad de conocer, en forma directa, la realidad de la problemática. Las unidades de observación fueron (188) historias clínicas de los pacientes que ingresaron en el servicio de medicina interna en el hospital Miguel Pérez Carreño en el periodo comprendido entre enero y abril de 2017. Resultados: En 30 de los pacientes se realizó el cultivo de la punta del catéter venoso central. En el 67% no hubo crecimiento de microorganismos, mientras que el 33% crecieron microorganismos a las 24 horas. El 80% de las muestras cultivadas reportan la presencia de Cocos Gram positivos. Un 10% reportaron enterobacterias y un 10% reportan levaduras, finalmente con menor frecuencia pseudomona con un 0%. Conclusiones: Solo 78 pacientes ameritaron la colocación de un catéter venoso central, de los cuales se cultivaron 30 puntas de catéter, encontrándose que solo 10 de las puntas de catéteres dieron positivas para infección con crecimiento bacteriano a las 24 horas, siendo los cocos Gram positivos la principal bacteria aislada en los pacientes con CVC seguidos de enterobacterias(AU)


Intravascular catheterization is used for hemodynamic monitoring, hemodialysis, metabolic and nutritional support, fluid administration, chemotherapy and prolonged antibiotic therapy, blood and derivatives, among others. In this study, infections caused by the use of (CVC) central venous catheter are reported, as well as the microorganisms present in patients. Methods: The research was of a retrospective, descriptive and cross-sectional type, with a non-experimental research design and aimed to know, in a direct way, the reality of the problem. The observation units were (188) clinical records of the patients admitted to the internal medicine service at the Miguel Pérez Carreño Hospital in the period between January and April 2017. Results In 30 of the patients, the culture of the tip of the central venous catheter. In 67% there was no growth of microorganisms, while 33% grew microorganisms at 24 hours. 80% of the cultivated samples report the presence of Gram-positive cocci. 10% reported enterobacteria and 10% reported yeast, finally with less frequency pseudomonas with 0%. Conclusions: Only 78 patients required placement of a central venous catheter, of which 30 catheter tips were cultured, finding that only 10 of the catheter tips were positive for infection with bacterial growth at 24 hours, with Gram-positive cocci. the main bacteria isolated in patients with CVCfollowed by enterobacteria(AU)


Subject(s)
Humans , Adolescent , Adult , Thrombophlebitis/diagnosis , Catheterization, Central Venous/methods , Gram-Positive Cocci , Endocarditis/diagnosis , Catheter-Related Infections/microbiology , Central Venous Catheters/adverse effects , Bacterial Infections , Medical Records/statistics & numerical data , Cross Infection/epidemiology , Retrospective Studies
15.
Article in Korean | WPRIM (Western Pacific) | ID: wprim-764190

ABSTRACT

PURPOSE: Ensuring the stability of central venous catheter placement for treating patients hospitalized in an intensive care unit is very important. Although PICC requires an ultrasound and fluoroscopy machine, it is difficult to use a fluoroscopy machine for PICC insertion in the intensive care unit. This study analyzed the cases of the insertion of a PICC under ultrasonic guidance at the bedsides in the intensive care unit to determine the usefulness of PICC in the intensive care unit. METHODS: A retrospective study was conducted on patients hospitalized in the surgical intensive care unit and received PICC using ultrasonography at their bedsides from October 2015 to January 2018. RESULTS: One hundred and twenty patients were collected. The number of successful PICCs stood at 105 patients, which was equal to 87.5%. Among them, 65 and 55 cases had left and right insertion, respectively; the corresponding success rate was 81.8%, and 92.3%. No statistically significant difference in success rates was observed between the left and right, as well as in the success rates depending on the presence of shock, sepsis, acute kidney injury, and mechanical ventilation. In the failed 15 cases, seven cases were due to the course of the procedure and eight cases were confirmed have been malpositioned after insertion. CONCLUSION: PICC at the bedside in an intensive care unit is a safe method for central venous catheterization without severe complications and death. The insertion sites, left or right, are equally acceptable. Further study of the cases of malposition will be necessary.


Subject(s)
Acute Kidney Injury , Catheterization , Catheterization, Central Venous , Catheters , Central Venous Catheters , Critical Care , Critical Illness , Fluoroscopy , Humans , Intensive Care Units , Methods , Respiration, Artificial , Retrospective Studies , Sepsis , Shock , Ultrasonics , Ultrasonography
16.
Rev. bras. ter. intensiva ; 30(4): 436-442, out.-dez. 2018. tab
Article in Portuguese | LILACS (Americas) | ID: biblio-977982

ABSTRACT

RESUMO Objetivo: Determinar os fatores de risco para contrair infecções da corrente sanguínea associadas a cateter de acesso central em unidades de terapia intensiva pediátrica, e investigar a incidência e a etiologia dessas infecções nas unidades de terapia intensiva pediátrica com diferentes perfis. Métodos: Este foi um estudo prospectivo de coorte, conduzido em três hospitais. Um deles é um grande hospital público metropolitano, com duas unidades de terapia intensiva pediátrica que contabilizam 19 leitos; o segundo é um hospital regional com oito leitos em unidade de terapia intensiva pediátrica; e o terceiro é um hospital privado com 15 leitos de terapia intensiva pediátrica. Incluíram-se pacientes com idades entre 1 mês e 18 anos, que utilizaram cateter de acesso venoso central por pelo menos 24 horas. Registramos a evolução diária dos pacientes. Colheram-se dados gerais sobre o paciente e sobre o cateter, utilizados como variáveis. Todos os dados foram analisados com utilização do pacote estatístico Statistical Package for Social Science (SPSS), versão 13.0, para comparação de pacientes com infecção da corrente sanguínea associada a cateter com ou sem fatores de risco. Resultados: Durante o período do estudo admitiram-se às unidades de terapia intensiva 728 pacientes; deles, 170 tiveram cateter de acesso venoso central instalado por, no mínimo, 24 horas. A mediana de idade foi de 32 meses, e 97 (57%) dos pacientes eram do sexo masculino. A taxa de incidência de infecções da corrente sanguínea relacionadas a cateter foi de 3,9/1.000 cateteres venosos centrais-dias. A incidência variou entre os hospitais, sendo de 1,6 a 6,6. A taxa geral de mortalidade foi de 11,1%, e as taxas de mortalidade com e sem infecções da corrente sanguínea relacionadas a cateter foram, respectivamente, de 12,9% e 10,7%. Na análise multivariada, os fatores de risco para ocorrência de infecções da corrente sanguínea relacionadas a cateter foram maior tempo de uso do cateter venoso central (OR: 1,07; IC95% 1,00 - 1,14; p = 0,019) e o uso de mais de um cateter venoso central de uma vez (OR: 2,59; IC95% 1,17 - 5,73; p = 0,048). Conclusão: Maior duração do uso de cateter venoso central e mais de um cateter venoso central de uma vez foram os principais fatores de risco para infecções da corrente sanguínea associadas a cateter em unidades de terapia intensiva pediátrica.


ABSTRACT Objectives: To determine the risk factors for acquiring central line-associated blood stream infections (CLABSI) in pediatric intensive care units and to investigate the incidence and etiology of CLABSI in pediatric intensive care units with different profiles. Methods: The study was a prospective cohort study in three hospitals. One of the hospitals is a large metropolitan public hospital with two pediatric intensive care units and a total of nineteen pediatric intensive care unit beds, another is a regional hospital with eight pediatric intensive care unit beds, and the third is a private hospital with fifteen beds. Patients between the ages of 1 month old and 18 years old who used a central venous catheter for over 24 hours were included. We recorded patients' daily progress. General patient and catheter-related data were collected and used as variables. All the data were analyzed using Statistical Package for Social Science (SPSS), version 13.0, to compare patients with CLABSI with or without risk factors. Results: A total of 728 patients were admitted to the pediatric intensive care units, and 170 had a central line in place for at least 24 hours. The median age was 32 months, and 97 (57%) of the patients were males. The CLABSI incidence rate was 3.9/1000 central venous catheter-days. The incidence among hospitals varied from 1.6 to 6.6. The overall mortality rate was 11.1%, and the CLABSI and non-CLABSI mortality rates were 12.9% and 10.7%, respectively. In multivariate analysis, independent risk factors for CLABSI were a longer duration of central venous catheter use (OR: 1.07; 95%CI 1.00 - 1.14; p = 0.019) and the use of more than one central venous catheter at once (OR: 2.59; 95%CI 1.17 - 5.73; p = 0.048). Conclusion: A longer duration of central venous catheter use and the use of more than one central venous catheter at once were the main risk factors for CLABSI in pediatric intensive care units.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Catheterization, Central Venous/adverse effects , Intensive Care Units, Pediatric , Catheter-Related Infections/epidemiology , Central Venous Catheters/adverse effects , Time Factors , Catheterization, Central Venous/methods , Incidence , Multivariate Analysis , Prospective Studies , Risk Factors , Cohort Studies , Catheter-Related Infections/etiology , Catheter-Related Infections/mortality
17.
J. bras. econ. saúde (Impr.) ; 10(3): 239-245, dez. 2018.
Article in Portuguese | LILACS (Americas), ECOS | ID: biblio-980933

ABSTRACT

Objetivo: O avanço da tecnologia no setor da saúde vem provocando, principalmente às Operadoras de Saúde, uma discussão sobre qual o melhor caminho para a incorporação de novos produtos médico-hospitalares. O objetivo deste estudo é fazer uma análise de custo comparando uma nova tecnologia (seringa pré-enchida) com uma tecnologia usual (seringa preenchida manualmente) em pacientes em uso de cateter venoso central (CVC). Métodos: Uma avaliação econômica baseada em modelo de Árvore de decisão foi desenvolvida para avaliar a seringa pré-enchida comercialmente em comparação com a seringa preenchida manualmente com solução salina para flushing em pacientes com CVC, considerando-se a perspectiva das operadoras de saúde. O horizonte de tempo considerado foi de um ano. Como desfechos clínicos, foram adotadas a ocorrência de infecção da corrente sanguínea associada a cateter (ICSAC) e a de oclusões. Para os desfechos econômicos, foram considerados os custos com flush, redução de ocorrência de ICSAC e da oclusão. Todos os custos foram extraídos de base de dados locais de custo para o Brasil. Resultados: A avaliação econômica mostrou que o uso da seringa pré-enchida promove redução de 77% (1,17 vs. 5,10) e 62% (3,26 vs. 8,57) nas ocorrências de ICSAC e oclusão, respectivamente, comparada à seringa de preenchimento manual. O custo por flushing é de R$ 32,88 e R$ 98,48 para seringa pré-enchida e seringa preenchida manualmente, respectivamente, redução absoluta de R$ 65,60 e percentual de 67%. Conclusão: A utilização da seringa pré-enchida comercialmente demonstrou ser uma opção dominante econômica e clinicamente para o flushing em pacientes com CVC, quando comparada à seringa preenchida manualmente.


Objective: The advancement of technology in the health sector has brought, mainly to the Health Insurances, a discussion on what is the best path for the incorporation of new medical and hospital products. The objective of this study is to do a cost analysis comparing a new technology (pre-filled syringe) with a usual technology (manually filled syringe) in patients in use of central venous catheter (CVC). Methods: An economic assessment based on a Decision Tree model was developed to evaluate the commercially pre-filled syringe in comparison to the manually filled syringe with saline solution for flushing in patients with CVC, considering the perspective of private health care providers. The time horizon considered was 1 year. As clinical outcomes, the occurrence of central line-associated blood stream (CLABSI) and occlusions were adopted. For economic outcomes, we considered flush costs, reduction of CLABSI and occlusion. All costs were extracted from local cost database for Brazil. Results: The economic evaluation indicated that the use of the pre-filled syringe presented a reduction of 77% (1.17 vs. 5.10) and 62% (3.26 vs. 8.57) in the occurrences of CLABSI and occlusion, respectively, compared to the manually filled syringe. The cost per flushing is R$ 32.88 and R$ 98.48 for pre-filled syringe and manually filled syringe, respectively, representing an absolute reduction of R$ 65.60 and percentual of 67%. Conclusion: The use of the commercially pre-filled syringe has been shown to be an economically and clinically dominant option for flushing in patients with CVC when compared to the manually filled syringe.


Subject(s)
Humans , Syringes , Catheterization, Central Venous , Costs and Cost Analysis , Catheter-Related Infections , Catheter Obstruction
18.
J. vasc. bras ; 17(4): 322-327, out.-dez. 2018. ilus
Article in Portuguese | LILACS (Americas) | ID: biblio-969136

ABSTRACT

Complicações relacionadas ao acesso venoso cervicotorácico, como os pseudoaneurismas (PAs), podem ser devastadoras. Neste artigo, apresentamos dois casos semelhantes em que o avanço tecnológico impactou no diagnóstico, tratamento e resultados. Ambos pacientes apresentaram volumoso PA após a tentativa de punção venosa profunda. O primeiro caso, em 1993, diagnosticado por duplex scan , revelou grande PA oriundo da artéria subclávia direita. A artéria foi abordada por esternotomia mediana com extensão supraclavicular. O PA originava-se do tronco tireocervical, tratado com simples ligadura. No segundo caso, em 2017, angiotomografia revelou um PA originário da artéria vertebral, que foi tratado com técnica endovascular, mantendo a perviedade do vaso. Ambos evoluíram satisfatoriamente, apesar de abordagens bastante diferentes. A lesão vascular cervicotorácica representa um desafio propedêutico e terapêutico, com alto risco de ruptura. Os avanços tecnológicos diminuem os riscos de lesões vasculares com acesso cirúrgico difícil e devem estar entre as opções do cirurgião vascular


Complications such as pseudoaneurysms (PA) related to cervicothoracic venous access can be devastating. In this article, we present two similar cases in which technological advances impacted diagnosis, treatment, and results. Both patients developed massive PA after deep venous puncture attempts. The first case occurred in 1993 and was diagnosed by a duplex scan that revealed a large PA originating from the right subclavian artery. The artery was approached by median sternotomy with supraclavicular extension. The PA originated from the thyrocervical trunk and was treated with simple ligation. The second case was in 2017. Angiotomography revealed a PA originating in the vertebral artery, which was treated with endovascular techniques, maintaining vessel patency. Both patients progressed satisfactorily, despite quite different approaches. Cervicothoracic vascular lesions represent a diagnostic and therapeutic challenge, where the risk of rupture is high. Technological advances have reduced the risks involved in management of vascular injuries with difficult surgical access


Subject(s)
Humans , Female , Aged , Vertebral Artery , Aneurysm, False/therapy , Endovascular Procedures , Subclavian Artery , Catheterization, Central Venous/methods , Angiography/methods , Stents , Treatment Outcome , Echocardiography, Doppler, Color/methods , Sternotomy/methods , Hematoma
19.
Arch. argent. pediatr ; 116(3): 204-209, jun. 2018. tab, ilus, graf
Article in English, Spanish | LILACS (Americas), BINACIS | ID: biblio-950011

ABSTRACT

Introducción. La canalización vascular central en niños presenta alta complejidad técnica y dificultades. La ecografía vascular puede facilitar este procedimiento. Objetivo. Describir las características de las canalizaciones vasculares ecoguiadas en el paciente pediátrico crítico. Población y métodos. Las variables de interés registradas prospectivamente fueron los vasos más comúnmente canalizados, su localización, la medición del diámetro/profundidad, la tasa de éxito y las complicaciones presentadas, entre otras. Resultados. En 86 pacientes pediátricos, se realizaron 124 punciones vasculares. Los accesos vasculares fueron la vena femoral (39,7%), seguida de la arteria femoral (27,2%) y la vena yugular interna (14,7%). Los vasos femorales se localizaron a una profundidad de 0,75 ± 0,25 mm con un diámetro medio de 0,31 ± 0,16 mm. La profundidad de los vasos venosos yugulares fue menor (0,64 ± 0,24 mm) y su diámetro global, mayor (0,44 ± 0,19 mm). El número medio de intentos en las canalizaciones vasculares ecoguiadas fue de 2,2 ± 1,3. La tasa de éxito fue del 79% asociada a un mayor diámetro del vaso (0,39 ± 0,20 mm vs. 0,28 ± 0,13 mm, p 0,01) y un menor número de intentos (1,90 ± 1,16 vs. 3,45 ± 1,77, p= 0,001). Las complicaciones, fueron la punción accidental de otro vaso (5,3%) y el desarrollo de un hematoma durante la punción (2,3%). Conclusiones. La canalización vascular ecoguiada en los pacientes pediátricos estudiados permite visualizar los vasos y medir su profundidad y diámetro; presenta una alta tasa de éxito y se asocia a una baja tasa de complicaciones.


Introduction. Central vascular cannulation in children is a highly complex technique and poses many difficulties. Vascular ultrasound can make this procedure easier. Objective. To describe the characteristics of ultrasound-guided vascular cannulation in critically-ill pediatric patients. Population and methods. Outcome measures prospectively recorded were vessels most frequently cannulated, their localization, the measurement of their diameter/depth, the success rate and complications developed, among others. Results. One hundred and twenty four vascular punctures were performed in 86 pediatric patients. Vascular accesses were the femoral vein (39.7%), followed by the femoral artery (27.2%) and the internal jugular vein (14.7%). Femoral vessels were localized at a depth of 0.75 ± 0.25 mm, with a mean diameter of 0.31 ± 0.16 mm. The depth of jugular vein vessels was smaller (0.64 ± 0.24 mm) and their overall diameter, larger (0.44 ± 0.19 mm). The mean number of attempts in ultrasound-guided cannulations was 2.2 ± 1.3. The success rate was 79% and was associated to a larger vessel diameter (0.39 ± 0.20 mm vs. 0.28 ± 0.13 mm, p= 0.01) and a lower number of attempts (1.90 ± 1.16 vs. 3.45 ± 1.77, p= 0.001). Complications were accidental puncture of another vessel (5.3%) and hematoma formation during puncture (2.3%). Conclusions. In the pediatric patients studied, ultrasound-guided vascular cannulation allowed vessel visualization and measurement of their depth and diameter; the success rate was high and it was associated to a low complication rate.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Catheterization, Central Venous/methods , Ultrasonography, Interventional/methods , Femoral Artery/diagnostic imaging , Femoral Vein/diagnostic imaging , Jugular Veins/diagnostic imaging , Catheterization, Central Venous/adverse effects , Prospective Studies , Outcome Assessment, Health Care , Critical Illness , Hematoma/etiology , Hematoma/epidemiology
20.
Belo Horizonte; s.n; 3-Abr-2018. 80 p.
Thesis in Portuguese | LILACS (Americas), ColecionaSUS | ID: biblio-1099503

ABSTRACT

As infecções relacionadas à assistência à saúde (IRAS) são eventos adversos preocupantes em saúde pública, que se configuram como importante causa de morbidade e mortalidade em unidades de terapia intensiva. Dispositivos invasivos como o cateter venoso central (CVC) favorecem um tipo de IRAS, a infecção da corrente sanguínea. Esse evento é comumente diagnosticado por hemocultura e ou cultura da ponta do cateter, entretanto nem sempre o tempo de resposta dos exames ou os achados contribuem com o adequado tratamento. Os avanços em biotecnologia apontam ferramentas capazes de contribuir com diagnósticos de infecção. O objetivo da presente tese foi testar a técnica de reação em cadeia da polimerase (PCR) como ferramenta para detecção de bactérias potencialmente patogênicas em ponta de CVC de pacientes com suspeita de infecção da corrente sanguínea relacionada ao cateter, internados na Unidade de Terapia Intensiva de Adultos de um hospital filantrópico e de ensino no interior de Minas Gerais. Foram abordados os temas extração de DNA e rastreamento molecular em CVC. Tratou-se de um estudo molecular, transversal, descritivo e exploratório. Testes laboratoriais de comparação entre métodos de extração de DNA foram realizados com cepa da bactéria Staphylococcus aureus para posterior aplicação em cateteres coletados de pacientes. Durante um período de seis meses, uma amostra de conveniência com trinta e quarto cateteres removidos de pacientes internados na Unidade de Terapia Intensiva de Adultos, sob suspeita de infecção da corrente sanguínea, foram submetidos à extração de DNA do material biológico contido na parede externa e no interior dos lúmens dos mesmos. Procedeu-se a identificação de bactérias por PCR utilizando um padrão de reagentes e temperaturas. Os resultados encontrados na análise por biologia molecular foram comparados com os resultados das culturas desses pacientes, realizadas pelo hospital. Houve ainda, o levantamento em prontuário de dados dos pacientes: sexo, idade, uso de outros dispositivos invasivos, tempo de permanência do CVC e local de inserção do cateter; e presença de sinais flogísticos no local de inserção do dispositivo. Testes estatísticos com auxílio do programa Stata, versão 15, foram utilizados. A prevalência das bactérias no CVC por teste de PCR foi: Staphylococcus aureaus (50%), Enterococcus faecalis (41,2%), Klebsiella pneumoniae (32,4%), Pseudomonas aeruginosa (20,6%), Acinetobacter baumannii (38,2%) e Escherichia coli (2,9%). Todas as hemoculturas realizadas tiveram ausência de bactérias como resultado do exame. A cultura de ponta de cateter revelou bactérias em 21 (61,8%) dispositivos, enquanto a PCR apresentou positividade em 31 (91,2%). Os patógenos mais detectados são comumente encontrados no ambiente e no microbioma humano, transmitidos aos pacientes inclusive pelas mãos dos profissionais de saúde. Estes achados são relevantes ao se programar medidas de prevenção de infecção da corrente sanguínea relacionada ao CVC. O método de extração do material genômico, o painel de primers e protocolo de amplificação deste estudo identificaram os principais bactérias comumente prevalentes nas infecções da corrente sanguínea. Desta forma, a identificação molecular de bactérias poderá auxiliar na detecção de infecção da corrente sanguínea e a tomada de decisão relativa à escolha da melhor terapia.


Healthcare-associated infections (HAIs) are worrying adverse events in public health. They are an important cause of morbidity and mortality in intensive care units. Invasive devices such as the central venous catheter (CVC) favors a type of HAIs, the bloodstream infection. This event is commonly diagnosed by blood culture and/or culture of the catheter tip, however, the response time of these tests or their results not always contribute to the appropriate treatment. Advances in biotechnology provide tools capable of contributing to diagnoses of infection. The aim of the present thesis was to detect potentially pathogenic bacteria at the tip of a central venous catheter through polymerase chain reaction (PCR). Subjects were treated with DNA extraction and molecular tracing in CVC. It is a cross-sectional molecular study. Laboratory tests comparing DNA extraction methods were performed with the Staphylococcus aureus bacterium for subsequent application to catheters collected from patients. Over a period of 6 months, in an Adult Intensive Care Unit of a philanthropic and training hospital, (n=34) catheters were removed from patients under suspicion of bloodstream infection. All the thirty-four catheters were subjected to DNA extraction from the biological material contained in their wall and inside their lumens. The bacteria were identified by PCR using a standard set of reagents and temperatures. The results found in the analysis by molecular biology were compared with the results of the cultures of these patients, performed by the hospital. Collection of patients' data was also carried out: sex, age, use of other invasive devices, CVC insertion location and period of catheters use; and presence of phlogistic signs in the insertion site of the device. Statistical tests were used with the help of the Stata software, version 15. The prevalence of bacteria in CVCs was: Staphylococcus aureaus (50%), Enterococcus faecalis (41,2%), Klebsiella pneumoniae (32,4%), Pseudomonas aeruginosa (20,6%), Acinetobacter baumannii (38,2%) and Escherichia coli (2,9%). All blood cultures performed had no bacteria as a result of the examination. Catheter-tip culture revealed microorganisms in 21 (61.8%) devices, whereas PCR showed positivity in 31 (91.2%). The most commonly detected pathogens are usually found in the environment and in the microbioma of the skin and they are possibly transmitted to patients by the hands of health professionals. These findings are relevant when programming CVC-related bloodstream infection prevention measures. The genomic material extraction method, primers panel and amplification protocol of this study identified the major pathogens prevalent in bloodstream infections. In this way, molecular identification of bacteria may assist in the detection of bloodstream infection and decision-making regarding the choice of the best therapy.


Subject(s)
Humans , Adult , DNA, Bacterial , Catheterization, Central Venous , Polymerase Chain Reaction , Public Health , Cross Infection/diagnosis , Catheter-Related Infections , Intensive Care Units
SELECTION OF CITATIONS
SEARCH DETAIL