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1.
Rev. cuba. cir ; 60(3): e1070, 2021. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347395

ABSTRACT

Introducción: El secuestro pulmonar está representado por masas de tejido pulmonar displásico, no funcionante, sin comunicación con el árbol bronquial. Objetivo: Presentar tres casos de secuestro pulmonar intralobar tratados por el autor. Caso clínico: Se presentan tres pacientes tratados entre 2013 y 2018 con diagnóstico de secuestro pulmonar. Dos fueron del sexo masculino (44 y 60 años de edad) y una del femenino (20 años de edad). Los síntomas fueron dolor torácico (1) y cuadro de infección pulmonar grave (2). En dos enfermos el secuestro se localizó en el lóbulo inferior derecho y en uno en el inferior izquierdo. Las operaciones fueron lobectomías inferiores derecha (1) e izquierda (1) y bilobectomía inferior y media derechas por afectación del lóbulo medio. Dos tuvieron una evolución satisfactoria y uno presentó un empiema pleural que resolvió con tratamiento antibiótico. Conclusiones: Los secuestros pulmonares son raros y los síntomas suelen asociarse con infección pulmonar. En la mayoría de los casos es necesario realizar una lobectomía. La evolución postoperatoria suele ser buena(AU)


Introduction: Pulmonary sequestration is characterized by masses of dysplastic, nonfunctioning lung tissue, without any communication with the bronchial tree. Objective: To present three cases of intralobar pulmonary sequestration treated by the author. Clinical case: The respective cases are presented of three patients with a diagnosis of pulmonary sequestration treated between 2013 and 2018. Two were male (44 and 60 years old, respectively) and one was female (20 years old). Their symptoms were chest pain (1) and severe lung infection (2). In two patients, the sequestration was located in the lower right lobe, while, in one, it was in the lower left lobe. The operations were right (1) and left (1) lower lobectomies and right lower and middle bilobectomy due to middle lobe involvement. Two had a satisfactory evolution, while one presented a pleural empyema healed with antibiotic treatment. Conclusions: Pulmonary sequestration is rare and their symptoms are usually associated with pulmonary infection. In most cases, a lobectomy is necessary. The postoperative evolution is usually good(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Pneumonectomy/methods , Chest Pain/etiology , Thoracotomy/methods , Bronchopulmonary Sequestration/diagnosis , Anti-Bacterial Agents/therapeutic use
4.
Rev. bras. cir. cardiovasc ; 35(4): 573-576, July-Aug. 2020. tab, graf
Article in English | SES-SP, LILACS, SES-SP | ID: biblio-1137288

ABSTRACT

Abstract Left sinus of Valsalva aneurysm (SVA) is a very infrequent clinical entity. Valsalva aneurysms are often asymptomatic in right and non-coronary sinuses and the diagnosis is often incidental. A left SVA which presents with exertional chest pain due to compression of left coronary system arteries is extremely rare. In this case, we present a successful surgical repair of left SVA without aortic regurgitation or myocardial infarction in a 59-year-old male patient.


Subject(s)
Humans , Male , Middle Aged , Aortic Aneurysm/surgery , Aortic Aneurysm/complications , Aortic Aneurysm/diagnostic imaging , Sinus of Valsalva/surgery , Sinus of Valsalva/diagnostic imaging , Aortic Valve Insufficiency/surgery , Aortic Valve Insufficiency/diagnostic imaging , Chest Pain/etiology , Myocardial Infarction
5.
Rev. cuba. cir ; 58(2): e666, mar.-jun. 2019. graf
Article in Spanish | LILACS | ID: biblio-1093167

ABSTRACT

RESUMEN Se presenta una paciente de 54 años de edad con antecedentes de hipertensión arterial, que ingresa en el servicio de Medicina Interna por dolor torácico intenso, acompañado de falta de aire de moderada intensidad, decaimiento, tos y dificultad para tragar sobre todo los alimentos sólidos. Mediante estudios complementarios se diagnostica un tumor de mediastino anterior, lo que motiva su traslado al servicio de Cirugía General. En el acto quirúrgico se constata absceso del mediastino anterior, el cual se drena mediante esternotomía media, evoluciona favorablemente y es egresada 12 días después de la intervención quirúrgica(AU)


ABSTRACT We present a 54-year-old patient with a history of high blood pressure, admitted to the internal medicine service with severe chest pain, accompanied by a lack of air of moderate intensity, decay, cough and difficulty for swallowing, especially solid foods. Through complementary studies, an anterior mediastinal tumor is diagnosed, which motivates her transfer to the general surgery service. In the surgical act, abscess of the anterior mediastinum is verified and drained by means of median sternotomy. The patient evolves favorably and is discharged 12 days after the surgical intervention(AU)


Subject(s)
Humans , Female , Middle Aged , Chest Pain/etiology , Sternotomy/methods , Mediastinal Neoplasms/surgery , Mediastinal Neoplasms/diagnostic imaging
6.
Rev. Paul. Pediatr. (Ed. Port., Online) ; 37(2): 252-256, Apr.-June 2019. tab, graf
Article in English | LILACS | ID: biblio-1013282

ABSTRACT

ABSTRACT Objective: To highlight the importance of the new classification criteria for the macrophage activation syndrome (MAS) in systemic juvenile idiopathic arthritis in order to reduce morbidity and mortality outcome related to this disease. Case description: A 12-year-old female patient with diagnosis of systemic juvenile idiopathic arthritis under immunosuppression therapy for two years developed cough, acute precordial chest pain, tachypnea, tachycardia and hypoxemia for two days. Chest tomography showed bilateral laminar pleural effusion with bibasilar consolidation. The electrocardiogram was consistent with acute pericarditis and the echocardiogram showed no abnormalities. Laboratory exams revealed anemia, leukocytosis and increased erythrocyte sedimentation rate, as well as C-reactive protein rate and serum biomarkers indicative of myocardial injury. Systemic infection and/or active systemic juvenile idiopathic arthritis were considered. She was treated with antibiotics and glucocorticoids. However, 10 days later she developed active systemic disease (fever, evanescent rash and myopericarditis with signs of heart failure) associated with macrophage activation syndrome, according to the 2016 Classification Criteria for Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis. She was treated for five days with pulse therapy, using glucocorticoids, immunoglobulin and cyclosporine A, with improvement of all clinical signs and laboratory tests. Comments: Myopericarditis with signs of heart failure associated with MAS is a rare clinical presentation of systemic juvenile idiopathic arthritis. Macrophage activation syndrome occurs mainly during periods of active systemic juvenile idiopathic arthritis and may be triggered by infection. Knowledge about this syndrome is crucial to reduce morbidity and mortality.


RESUMO Objetivo: Destacar a importância do conhecimento sobre os novos critérios de classificação para síndrome de ativação macrofágica (SAM) na artrite idiopática juvenil sistêmica para reduzir a morbidade e mortalidade desse desfecho. Descrição do caso: Adolescente do sexo feminino de 12 anos de idade, em terapia imunossupressora por diagnóstico de artrite idiopática juvenil sistêmica há 2 anos, com quadro de tosse, dor precordial aguda, taquipneia, taquicardia e hipoxemia há 2 dias. A tomografia de tórax evidenciou efusão pleural laminar bilateral com consolidação bibasal. O eletrocardiograma foi compatível com pericardite aguda, e o ecocardiograma foi normal. Os exames laboratoriais revelaram anemia, leucocitose e aumento da velocidade de hemossedimentação, proteína C-reativa e marcadores séricos de lesão miocárdica. Infecção sistêmica e/ou doença sistêmica em atividade foram consideradas. A paciente foi tratada com antibióticos e glicocorticoide. Entretanto, dez dias depois, evoluiu com doença sistêmica em atividade (febre, exantema e miopericardite com insuficiência cardíaca) associada à SAM, de acordo com o 2016 Classification Criteria for Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis, e necessitou de cinco dias de pulsoterapia com glicocorticoide, imunoglobulina e ciclosporina A, com melhora de todos os parâmetros clínicos e laboratoriais. Comentários: A miopericardite com sinais de insuficiência cardíaca associada à SAM é uma apresentação clínica rara da artrite idiopática juvenil sistêmica, que ocorre principalmente em períodos de atividade sistêmica da doença e pode ser deflagrada por infecções. O conhecimento sobre essa síndrome é fundamental para reduzir morbidade e mortalidade desse grave desfecho.


Subject(s)
Humans , Female , Child , Cyclosporine/administration & dosage , Glucocorticoids/administration & dosage , Arthritis, Juvenile/complications , Arthritis, Juvenile/diagnosis , Arthritis, Juvenile/physiopathology , Arthritis, Juvenile/immunology , Chest Pain/diagnosis , Chest Pain/etiology , Tomography, X-Ray Computed/methods , Treatment Outcome , Immunoglobulins, Intravenous/administration & dosage , Pulse Therapy, Drug/methods , Electrocardiography/methods , Macrophage Activation Syndrome/etiology , Macrophage Activation Syndrome/physiopathology , Macrophage Activation Syndrome/blood , Macrophage Activation Syndrome/therapy , Immunosuppressive Agents/administration & dosage , Leukocytosis/diagnosis , Leukocytosis/etiology
7.
Arch. cardiol. Méx ; 89(1): 31-37, Jan.-Mar. 2019. tab, graf
Article in English | LILACS | ID: biblio-1038474

ABSTRACT

Abstract Introduction: Pediatric precordial pain is a frequent cause for pediatric consultation in the emergency room (ER) services - about 0.3-0.6% of all consultations - and it can cause a lot of stress to families who tend to associate it with a more severe pathology, this pathology mostly presents itself between the ages of 11 and 14 years. Objective: The objective of this study was to determine the precordial pain's etiology and to analyze the semiology and approach toward the ailment by ER service in a private hospital. Methods: A retrospective, observational, descriptive, transversal study that took place from January 2014 to May 2017. Results: A total of 48 precordial pain patients were identified, four of them had a positive family background. Most of the pain was not referred as associated to symptoms, and the type of pain was non-specific in 62% of the cases. The most frequent duration of the pain was < 8 h in 54.1% and without any irradiation. There was only one case associated with the presence of cardiac precordial pain pathology regarding pulmonary hypertension; this signified an incidence of 2%, similar to what has been previously published in other articles.


Resumen Introducción: El dolor precordial en pediatría es una causa frecuente de consulta en los servicios de urgencias, representando entre el 0.3-0.6% de todas las consultas en estos. servicios. Su edad de presentación más frecuente oscila entre los 11 y 14 años de edad. Objetivo: Determinar la etiología del dolor precordial así como analizar la semiología y el abordaje del mismo en el servicio de urgencias en un hospital privado de la ciudad de México. Metodología: Estudio retrospectivo, observacional, descriptivo, transversal, que se desarrolló de Enero del 2014 a Mayo del 2017. Resultados: Se estudiaron 48 pacientes, 4 tenian antecedentes familiares de importancia positivos, en su mayoría, los pacientes no refirieron síntomas asociados. En 62% de los pacientes refirieron un dolor precordial inespecífico en cuanto al tipo de dolor, en 54% la duración del dolor fue de 8 h sin irradiación. Solo se reporta un caso asociado a etiología cardíaca siendo un caso de hipertensión arterial pulmonar; con esto concluímos un incidencia del 2%.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Chest Pain/etiology , Cross-Sectional Studies , Retrospective Studies , Hospitals, Private , Emergency Service, Hospital , Mexico
8.
Rev. chil. radiol ; 24(4): 151-154, dic. 2018. ilus
Article in Spanish | LILACS | ID: biblio-978171

ABSTRACT

El dolor torácico es un motivo frecuente de consulta en los servicios de urgencias, sin embargo, el hematoma esofágico es una causa muy poco frecuente. Se manifiesta más frecuentemente en mujeres de edad media y avanzada, con una triada de dolor torácico súbito, disfagia u odinofagia y hematemesis. Presentamos un caso de una mujer de 89 años con antecedentes de hipertensión arterial en tratamiento, usuaria de antihipertensivos y aspirina, con una historia de dos días de evolución de dolor retroesternal, sensación febril, disnea y tos productiva secundario a un hematoma esofágico.


Thoracic pain is a frequent reason for consultation in the emergency department, however, esophageal hematoma is a very rare cause. It manifests more commonly in women of middle and advanced age, with a triad of sudden chest pain, dysphagia or odynophagia and hematemesis. We present a case of a 89 years old female patient, with a history of arterial hypertension in treatment, user of antihypertensive drugs and aspirin with a two day history of retrosternal pain, febrile sensation, dyspnea and productive cough due to a esophageal hematoma.


Subject(s)
Humans , Female , Aged, 80 and over , Esophageal Diseases/diagnostic imaging , Hematoma/diagnostic imaging , Chest Pain/etiology , Radiography, Thoracic , Tomography, X-Ray Computed , Esophageal Diseases/etiology
9.
Rev. pediatr. electrón ; 15(2): 19-25, ago. 2018.
Article in Spanish | LILACS | ID: biblio-994556

ABSTRACT

El dolor precordial en pediatría representa un bajo porcentaje del total de consultas, sin embargo genera una alta preocupación tanto en los padres como en el equipo de salud. En general se trata de un proceso benigno y la etiología cardíaca es infrecuente, alcanzando apenas el 1-4%. En el presente trabajo de actualización se revisan las diferentes etiologías, con el propósito de identificar factores que orienten a etiología cardíaca y así derivar al especialista u hospitalizar en forma oportuna si se requiere.


The chest pain in pediatrics represents a low percentage of the total of consultations, nevertheless it generates a high concern both in the parents and in the health team. In general, it is a benign process and the cardiac etiology is infrequent, reaching only 1-4%. In the present update work, the different etiologies are reviewed, in order to identify factors that guide the cardiac etiology and thus refer to the specialist or hospitalize in a timely manner if required.


Subject(s)
Humans , Child , Chest Pain/diagnosis , Chest Pain/etiology , Physical Examination , Chest Pain/therapy , Cardiovascular Diseases/complications
10.
Arch. cardiol. Méx ; 88(5): 391-396, dic. 2018. graf
Article in English | LILACS | ID: biblio-1142148

ABSTRACT

Abstract Objectives: To determine the usefulness of myeloperoxidase in discriminating between patients with acute coronary syndrome and patients with chest pain by other causes. Methods: The study included all patients over 18 years of age who come consecutively to the emergency department from September 2015 to December 2015 with chest pain of non- traumatic origin. The initial patient evaluation was performed according to the study protocol for patients with suspected acute coronary syndrome (ACS) in our Emergency Department. This included the serial measurement of troponin, and in this case myeloperoxidase, with serialization on admission and at 6 h. For the determination of myeloperoxidase (MPO), a single step sandwich enzyme immunoassay by Siemens, automated on a Dimension analyser, was used. Results: Statistically significant differences were observed in the concentration of myeloperoxidase at time 0 among patients diagnosed with ACS: 505 (413) pmol/L, and non-ACS patients: 388 (195) pmol/L (p < .001), as well as at 6 h (p < .001). An area under the curve ROC of 0.824 was obtained at 6 h for ACS patients, with a confidence interval of 95% from 0.715 to 0.933 and a level of significance of p <.001. Statistically significant differences were also found in the concentration of myeloperoxidase at time 0 and at 6 h among patients with ACS and patients with heart disease other than coronary artery disease. Conclusions: The concentration of MPO helps to differentiate between ACS and non-ACS patients, as well as between ACS patients and patients with heart diseases other than coronary artery disease.


Resumen Objetivos: Conocer la utilidad de mieloperoxidasa (MPO) para discriminar entre pacientes con síndrome coronario agudo y dolor torácico de otras causas. Métodos: De septiembre a diciembre de 2015 se incluyeron todos los pacientes mayores de 18 años que acudieron de forma consecutiva al servicio de urgencias con dolor torácico de origen no traumático. La evaluación inicial del paciente se realizó de acuerdo con el protocolo de estudio para pacientes con sospecha de síndrome coronario agudo (SCA) en nuestro servicio de urgencias, que incluye la medición de troponina y en este caso MPO, con serialización al ingreso y a las 6 h. Para la determinación de MPO se utilizó un inmunoensayo enzimático de tipo sándwich, de una sola etapa de Siemens, automatizado en un equipo Dimension . Resultados: Se obtuvieron diferencias estadísticamente significativas en la concentración de MPO a tiempo 0 entre los pacientes con diagnóstico de SCA: 505 (413) pmol/l y los pacientes no SCA: 388 (195 pmol/l (p < 0.001), así como a las 6 h (p < 0.001). Se obtuvo a las 6 h un área bajo la curva ROC para pacientes con SCA de 0.824 con un intervalo de confianza del 95% de 0.715 a 0.933 y un grado de significación p < 0.001. También se obtuvieron diferencias estadísticamente significativas en la concentración de MPO tanto a tiempo 0 como a las 6 h entre pacientes con SCA y pacientes con enfermedad cardiaca diferente de enfermedad coronaria. Conclusiones: La concentración de MPO sirve para diferenciar entre pacientes SCA y pacientes que no son SCA, así como entre pacientes SCA y pacientes con otras enfermedades cardiacas diferentes a la enfermedad coronaria.


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Chest Pain/etiology , Coronary Artery Disease/diagnosis , Peroxidase/metabolism , Acute Coronary Syndrome/diagnosis , Time Factors , Troponin/metabolism , Coronary Artery Disease/enzymology , Diagnosis, Differential , Emergency Service, Hospital , Acute Coronary Syndrome/enzymology , Acute Coronary Syndrome/physiopathology , Heart Diseases/diagnosis , Heart Diseases/enzymology
11.
Arch. cardiol. Méx ; 88(5): 333-338, dic. 2018. graf
Article in Spanish | LILACS | ID: biblio-1142139

ABSTRACT

Resumen Objetivo: El dolor torácico es un importante motivo de atención en salas de urgencia a nivel mundial. Se evaluó la relación entre el score HEART modificado y la presencia de eventos cardiacos mayores a los 30 días. Métodos: Estudio retrospectivo, observacional en un solo centro hospitalario. En pacientes mayores de 18 años atendidos en urgencias por dolor torácico, en los cuales se aplicó el score HEART modificado al ingreso y se relacionó con la presencia de eventos cardiacos mayores (infarto de miocardio, muerte, re hospitalización por causa cardiaca y revascularización coronaria percutánea o quirúrgica) a los 30 días de seguimiento. Resultados: De 158 pacientes analizados, 17 eventos adversos (10.8%) se encontraron al mes de seguimiento. El score HEART modificado pudo predecir eventos adversos en el 4; 21,4 y 100% de pacientes con scores 0-3, 4-6 y 7-10 respectivamente (p = 0.0001). Un score HEART modificado mayor o igual a 4 se relacionó con más eventos adversos (OR: 4.52; IC: 2.76-7.39) con una sensibilidad del 70% y una especificidad del 84%. Conclusiones: La aplicación del score HEART modificado estratifica a los pacientes con dolor torácico en urgencias de manera adecuada en bajo, moderado y alto riesgo de complicaciones cardiovasculares, lo cual permite que las unidades de urgencia mejoren sus protocolos de triaje y diagnóstico de los síndromes coronarios agudos.


Abstract Objective: Chest pain is a major reason for emergency room care worldwide. The relationship between the Modified Heart Score and the presence of major cardiac events at 30 days after emergency admission was evaluated. Methods: Retrospective, observational study in a single centre on patients older than 18 years, who were treated for chest pain. The Modified HEART Score was applied at admission and related to the presence of major cardiac events (myocardial infarction, death, hospital re-admission due to cardiac causes, and percutaneous or surgical coronary revascularisation) at 30 days of follow-up. Results: Of 158 patients analysed, 17 (10.8%) adverse events were found at follow-up. The modified HEART score could predict adverse events in 4%; 21.4%, and 100% of patients with scores 0-3; 4-6, and 7-10, respectively (P = .0001). A modified HEART score greater than or equal to 4 was associated with more adverse events (OR: 4.52; 95% CI 2.76-7.39) with a sensitivity of 70% and specificity of 84%. Conclusions: The application of the modified HEART score is useful for stratifying patients with chest pain into low, moderate, and high risk of cardiovascular complications, which should help the emergency units to improve their protocols for triage and diagnosis of acute coronary syndromes.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Chest Pain/etiology , Triage/methods , Emergency Service, Hospital , Acute Coronary Syndrome/diagnosis , Patient Readmission/statistics & numerical data , Cardiovascular Diseases/epidemiology , Retrospective Studies , Follow-Up Studies , Sensitivity and Specificity , Acute Coronary Syndrome/physiopathology , Myocardial Infarction/epidemiology
13.
Medwave ; 18(5): e7249, 2018.
Article in English, Spanish | LILACS | ID: biblio-915380

ABSTRACT

Resumen: El síndrome aórtico agudo incluye un grupo de enfermedades que poseen similitud clínica en su historia natural, siendo la característica más importante su asociación a un alto riesgo vital. Entre estas patologías, el diagnóstico y manejo de la disección aórtica depende del grado de compromiso aórtico según la ubicación de la lesión definida bajo la clasificación de Stanford. Dentro de las manifestaciones clave se considera al dolor torácico como el síntoma cardinal. Sin embargo, existen situaciones que por ambigüedad clínica retrasan el diagnóstico. Se presenta el caso de un paciente que debutó con una disección aórtica Stanford A, con indicación de resolución quirúrgica en fase aguda pero que dado lo inespecífico de su cuadro clínico, no se logró un diagnóstico oportuno. Posterior a reiteradas consultas por cambios en su sintomatología, se determinó el cuadro definitivo a través de estudio imagenológico, evolucionando de forma favorable con terapia ambulatoria.


Abstract: Acute aortic syndrome includes a group of diseases that have clinical similarity in their natural history, the most important characteristic being their association with a high vital risk. The diagnosis and management of aortic dissection depends on the degree of aortic involvement according to the location of the lesion, as defined by the Stanford classification. In this syndrome, chest pain is considered the cardinal symptom; however, there are situations where clinical feedback is difficult. We present the case of a patient who debuted with a Stanford A aortic dissection, with an indication for surgical resolution in the acute phase, but who unexpectedly presented unspecific clinical manifestations. An opportune diagnosis was not obtained. After repeated consultations for changes in his symptoms, the definitive diagnosis was determined through imaging study, evolving favorably with ambulatory therapy.


Subject(s)
Humans , Male , Middle Aged , Chest Pain/etiology , Aneurysm, Dissecting/diagnosis , Delayed Diagnosis , Aneurysm, Dissecting/physiopathology
14.
Rev. chil. enferm. respir ; 34(1): 55-58, 2018. graf
Article in Spanish | LILACS | ID: biblio-959408

ABSTRACT

Resumen El secuestro pulmonar es una malformación pulmonar rara, presentándose generalmente en edades tempranas. Se presenta mayoritariamente con neumonías e infecciones repetidas, distrés respiratorio y falla cardíaca; raramente en pacientes de mayor edad se presenta con hemoptisis y dolor torácico. En este artículo se describe el caso clínico de un paciente de 60 años de edad que se presenta con un infarto de un secuestro pulmonar y hemotórax.


Bronchopulmonary sequestration is a rare pulmonary malformation, usually occurring at an early age. It presents mainly with pneumonia and repetitive infections, respiratory distress and heart failure; rarely in aged patients presents with hemoptysis and chest pain. This article describes the clinical case of a 60-year-old male patient who presented an ischemic pulmonary sequestration and hemothorax.


Subject(s)
Humans , Male , Middle Aged , Chest Pain/etiology , Bronchopulmonary Sequestration/complications , Bronchopulmonary Sequestration/diagnostic imaging , Hemothorax , Chest Pain/diagnosis , Chest Pain/therapy , Radiography, Thoracic , Tomography, X-Ray Computed , Bronchopulmonary Sequestration/surgery , Hemoptysis
15.
In. Soeiro, Alexandre de Matos; Leal, Tatiana de Carvalho Andreucci Torres; Oliveira Junior, Múcio Tavares de; Kalil Filho, Roberto. Manual da condutas da emergência do InCor: cardiopneumologia / IInCor Emergency Conduct Manual: Cardiopneumology. São Paulo, Manole, 2ª revisada e atualizada; 2017. p.71-79.
Monography in Portuguese | LILACS | ID: biblio-848461
18.
Gut and Liver ; : 37-41, 2016.
Article in English | WPRIM | ID: wpr-111620

ABSTRACT

BACKGROUND/AIMS: Proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a newly recognized form of eosinophilic esophagitis (EoE) that responds to PPI therapy. It remains unclear whether PPI-REE represents a subphenotype of gastroesophageal reflux disease, a subphenotype of EoE, or its own distinct entity. The aim was to evaluate the clinicopathologic features of PPI-REE. METHODS: Six patients were diagnosed with PPI-REE based on symptoms, endoscopic abnormalities, esophageal eosinophilia with > or =15 eosinophils/high-power field, and a response to PPI treatment. Symptoms and endoscopic and pathological findings were evaluated. RESULTS: The median follow-up duration was 12 months. Presenting symptoms included dysphagia, heartburn, chest pain, foreign body sensation, acid reflux, and sore throat. All patients had typical endoscopic findings of EoE such as esophageal rings, linear furrows, nodularity, and whitish plaques. Three patients had a concomitant allergic disorder, and one had reflux esophagitis. Four patients exhibited elevated serum IgE, and five had positive skin prick tests. All patients experienced symptomatic resolution within 4 weeks and histologic resolution within 8 weeks after starting PPI therapy. There was no symptomatic recurrence. CONCLUSIONS: PPI therapy induced rapid resolution of symptoms and eosinophil counts in patients with PPI-REE. Large-scale studies with long-term follow-up are warranted.


Subject(s)
Adult , Asian Continental Ancestry Group , Chest Pain/etiology , Deglutition Disorders/etiology , Diagnosis, Differential , Eosinophilic Esophagitis/complications , Esophagus/pathology , Female , Follow-Up Studies , Gastroesophageal Reflux/etiology , Heartburn/etiology , Humans , Male , Middle Aged , Pharyngitis/etiology , Phenotype , Proton Pump Inhibitors/therapeutic use , Republic of Korea , Retrospective Studies , Sensation Disorders/etiology , Treatment Outcome , Young Adult
19.
Gut and Liver ; : 152-155, 2016.
Article in English | WPRIM | ID: wpr-111604

ABSTRACT

Noncardiac chest pain (NCCP) is one of the most common esophageal symptoms and lacks a clearly defined mechanism. The most common cause of NCCP is gastroesophageal reflux disease (GERD). One of the accepted mechanisms of NCCP in a patient without GERD has been altered visceral sensitivity. Mast cells may play a role in visceral hypersensitivity in irritable bowel syndrome. In this case, a patient with NCCP and dysphagia who was unresponsive to proton pump inhibitor treatment had an increased esophageal mast cell infiltration and responded to 14 days of antihistamine and antileukotriene treatment. We suggest that there may be a relationship between esophageal symptoms such as NCCP and esophageal mast cell infiltration.


Subject(s)
Adult , Chest Pain/etiology , Esophageal Diseases/complications , Esophagus/cytology , Female , Histamine Antagonists/therapeutic use , Humans , Leukotriene Antagonists/therapeutic use , Mast Cells/metabolism , Mastocytosis/complications
20.
In. Kalil Filho, Roberto; Fuster, Valetim; Albuquerque, Cícero Piva de. Medicina cardiovascular reduzindo o impacto das doenças / Cardiovascular medicine reducing the impact of diseases. São Paulo, Atheneu, 2016. p.531-543.
Monography in Portuguese | LILACS | ID: biblio-971554
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