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1.
Int. j. cardiovasc. sci. (Impr.) ; 32(3): 274-282, May-June 2019. tab, ilus
Article in English | LILACS | ID: biblio-1002225

ABSTRACT

Cardiovascular diseases (CVD) are the main cause of death globally and most CVD can be prevented by addressing their risk factors, such as an unhealthy diet. Many authors have studied the benefits of nut consumption on CVD. Nuts contain high amounts of vegetable protein, unsaturated fatty acids, dietary fibers, vitamins, minerals and many other bioactive compounds, like phytosterols and phenolic compounds, which are able to reduce cholesterol levels and promote antioxidant and anti-inflammatory effects, thereby reducing cardiovascular risks. This review aims to describe studies involving the consumption of nuts, including Brazil nuts and CVD risk factors with positive results in the improvement of lipid profile, glucose metabolism, vascular function, and inflammatory and oxidative stress biomarkers


Subject(s)
Humans , Male , Female , Brazil , Cardiovascular Diseases/mortality , Nuts , Seeds , Biomarkers , Cholesterol , Risk Factors , Diet, High-Protein , Hypertension , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Anti-Inflammatory Agents , Antioxidants
2.
Med. leg. Costa Rica ; 33(2): 12-19, sep.-dic. 2016. tab
Article in Spanish | LILACS | ID: lil-795902

ABSTRACT

Resumen:Justificación: conocer el nivel de alteración de los componentes del síndrome metabólico en la población permite evaluar el riesgo de desarrollar diabetes mellitus tipo 2 y enfermedades cardiovasculares.Objetivo: comparar los valores sanguíneos de tres analitos del síndrome metabólico (triglicéridos, glucosa y colesterol HDL) en adultos de ambos sexos de Consulta Externa del Hospital de Guápiles, en el año 2015, con respecto a los valores de referencia según la NCEP ATP III.Métodos: se tomaron valores de glucosa, triglicéridos y colesterol HDL de la base de datos del Laboratorio del Hospital de Guápiles, del año 2015. Luego se procedió a determinar por sexo, por grupo de edad y en forma combinada (hombres y mujeres) la alteración, absoluta y porcentual, de cada analito con respecto a los valores de referencia de la NCEP ATP III. Además, se determinó el perfil de alteración (frecuencia absoluta y porcentaje) por sexo, por grupo de edad y combinado.Resultados: en las mujeres el HDL-C es el parámetro más alterado, con un 75.3% de las pacientes teniéndolo disminuido. Lo mismo sucede analizando por grupo de edad. En los hombres el parámetro más alterado es también el HDL-C (60.1 %), seguido de los triglicéridos (53.8 %). En las mujeres la alteración únicamente del HDL-C es la situación más común (31.1%), seguida de la alteración conjunta de TRG-HDL-C (22.6 %). En los hombres la situación se invierte: la alteración de TRG-HDL-C es la más frecuente (25.4 %), seguida de la de HDL-C (13.8 %).Discusión: los parámetros que más se alteraron fueron los lipídicos. Además, conforme aumentaba la edad se incrementaban el porcentaje de valores alterados y el porcentaje de pacientes con los tres analitos alterados. El aumento del sedentarismo, del sobrepeso y de la obesidad con la edad ayuda a explicar este fenómeno.


Abstract:Justification: Knowing the degree of alteration in the metabolic syndrome's components within the target population allows us to evaluate the risk of developing type 2 diabetes mellitus and cardiovascular diseases.Objective: To compare the blood values of three analytes of the metabolic syndrome (triglycerides, glucose, and HDL cholesterol) taken from adult outpatients from Hospital de Guápiles, from both sexes, during the year 2015, in accordance to the reference values of NCEP ATP III.Methods: Glucose, triglycerides, and HDL cholesterol values were taken from Hospital de Guápiles' Laboratory, belonging to the year 2015. The absolute and percentage alteration of each analyte was determined according to sex, age group, as well as in a joint manner (both men and women), following the reference values of NCEP ATP III.The alteration profile (absolute frequency and percentage) was also determined according to sex, age group, andin a joint manner.Results: HDL-C in women is the most altered parameter, with a 73% of the patients exhibiting it diminished. The same occurs when analyzing it by age group. In men the most altered parameter is also HDL-C (60.1%), followed by triglycerides (53.8%). The most common situation for women is the exclusive alteration of HDCL-C (3.1%), followed by the joint alteration of TRG-HDL-C (22.6%). For men it is rather the opposite: TRG-HDL-C is the most frequent (25.4), being followed by HDL-C (13-8%).Discussion: The most altered parameters were lipids. Also, as the age increased, so did the percentage of altered values, as well as the percentage of patients who had the three analytes altered. The age-related increase of a sedentary lifestyle, and overweight condition and obesity helps to explain this phenomenon.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Triglycerides/analysis , Metabolic Syndrome/blood , Cholesterol, HDL/analysis , Costa Rica , Sedentary Behavior
3.
Int. j. cardiovasc. sci. (Impr.) ; 29(5): f:355-l:361, set.-out. 2016. tab
Article in Portuguese | LILACS | ID: biblio-832702

ABSTRACT

Fundamento: A ação antioxidante de alguns nutrientes é importante na proteção vascular. O zinco, em particular, tem sido associado a um risco reduzido de aterosclerose, acidente vascular cerebral e trombose.Objetivo: O estudo avaliou o status do zinco e sua relação com biomarcadores de risco cardiovascular em adultos saudáveis. Métodos: Estudo transversal com 186 estudantes universitários de ambos os sexos, com idades entre 20 e 30 anos, selecionados através de amostra por conveniência. As medições dos biomarcadores de risco cardiovascular incluíram o perfil lipídico, o índice de Castelli I e II e circunferência da cintura. O zinco dietético foi avaliado por registro alimentar de três dias utilizando o programa NutWin versão 1.6.0.7. As concentrações plasmáticas e de eritrócitos do mineral foram determinadas por espectrofotometria de absorção atômica com chama. O perfil lipídico foi determinado pelo método enzimático colorimétrico. Resultados: Os valores médios do consumo de zinco estavam superiores à NME (Necessidade Média Estimada) em ambos os sexos. Os participantes apresentaram concentrações médias de zinco no plasma e eritrócitos inferiores aos pontos de corte. Os valores médios do perfil lipídico, índice de Castelli I e II, e circunferência da cintura estavam adequados. Houve correlação negativa entre o zinco dietético e colesterol total e triglicérides. Conclusões: Os participantes têm uma ingestão elevada de zinco e apresentam concentrações plasmáticas e eritrocitárias reduzidas do mineral. Além disso, esse estudo revelou uma associação negativa entre a ingestão de zinco dietético e o colesterol total e triglicérides, biomarcadores do risco cardiovascular, sugerindo a importância do zinco na proteção contra doenças cardiovasculares


Background: The antioxidant action of some nutrients is important in vascular protection. Zinc, particularly, has been associated with reduced risk of atherosclerosis, stroke and thrombosis. Objective: The study evaluated zinc status and its association to cardiovascular risk biomarkers in healthy adults. Methods: Cross-sectional study with 186 university students of both genders, aged between 20 and 30 years, selected using the convenience sampling method. The cardiovascular risk biomarker measurements included the lipid profile, Castelli index I and II, and waist circumference. Zinc analysis was performed by a three-days food record using NutWin program version 1.6.0.7. Plasma and erythrocyte mineral concentrations were determined by flame atomic absorption spectrophotometry. The lipid profile was determined by enzymatic colorimetric methods. Results: The mean values of zinc intake were higher than the EAR in both genders. Participants had mean plasma and erythrocyte zinc concentrations lower than the cutoff points. The mean values of the lipid profile, Castelli index I and II, and waist circumference were adequate. There was a negative correlation between dietary zinc and total cholesterol and triglycerides. Conclusions: The participants have a high dietary zinc intake and reduced plasma and erythrocyte concentrations of this mineral. Additionally, this study showed a negative association between zinc dietary intake and total cholesterol and triglycerides, biomarkers of cardiovascular risk, suggesting the importance of zinc in protecting against cardiovascular disease


Subject(s)
Humans , Male , Female , Adult , Adult , Biomarkers , Cardiovascular Diseases/mortality , Diet/methods , Zinc/deficiency , Body Mass Index , Cholesterol, HDL/analysis , Cholesterol, HDL/blood , Cholesterol, LDL/analysis , Cholesterol, LDL/blood , Cross-Sectional Studies , Risk Factors , Sex Factors , Data Interpretation, Statistical , Waist Circumference
4.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 26(3): 195-204, jul.-set. 2016. tab, ilus
Article in Portuguese | LILACS | ID: biblio-832613

ABSTRACT

O Diabetes mellitus é uma doença com elevada prevalência global, associada à mortalidade cardiovascular e complicações microvasculares, que conferem o caráter crônico a essa patologia. No diabetes tipo II, o processo aterosclerótico tem início antes mesmo do diagnóstico, daí a importância do reconhecimento dos fatores de risco implicados na fisiopatologia da doença vascular nessa população. A dislipidemia no diabético é caracterizada por lipoproteínas ricas em triglicérides, LDL pequenas, densas e muito aterogênicas e HDL-c baixo. As estatinas são os medicamentos de escolha para tratar a dislipidemia e reduzir de forma significativa o risco cardiovascular nesses pacientes. Apesar do controle glicêmico intensivo não reduzir eventos cardiovasculares nos estudos randomizados, alguns hipoglicemiantes apresentam efeito favorável sobre o perfil lipídico, com redução de futuros eventos


Diabetes mellitus is a disease with high global prevalence, associated with cardiovascular mortality and microvascular complications, which give this disease its chronic nature. In type II diabetes, the atherosclerotic process begins even before diagnosis, hence the importance of recognizing the risk factors involved in pathophysiology of vascular disease in this population. Dyslipidemia in the diabetic patient is characterized by triglyceride-rich lipoproteins; small-dense and very atherogenic LDLs and low HDL-c. Statins are the drugs of choice for treating dyslipidemia and significantly reducing the cardiovascular risk in these patients. Although intensive glycemic control did not reduce cardiovascular events in randomized trials, some hypoglycemic drugs have demonstrated a favorable effect on the lipid profile, and may reduce future events


Subject(s)
Humans , Insulin Resistance , Diabetes Mellitus/diagnosis , Dyslipidemias/complications , Dyslipidemias/diagnosis , Hypertension/complications , Hypertension/physiopathology , Cardiovascular Diseases/physiopathology , Chronic Disease , Risk Factors , Lipoproteins/analysis , Lipoproteins/blood , Cholesterol, HDL/analysis , Cholesterol, HDL/blood , Cholesterol, LDL/analysis , Cholesterol, LDL/blood , Liver/physiopathology
5.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 26(3): 190-194, jul.-set. 2016. tab, ilus, graf
Article in Portuguese | LILACS | ID: biblio-832423

ABSTRACT

Os níveis de triglicérides plasmáticos são biomarcadores das lipoproteínas ricas em triglicérides circulantes e de seus remanescentes. Formas leves a moderadas de hipertrigliceridemia podem ser secundárias a outras desordens metabólicas, fatores ambientais ou medicamentos, ou ainda poligênicas. Já as formas mais graves são, em geral, monogênicas e resultam de alterações em seis genes. Fatores não genéticos podem exacerbar as hipertrigliceridemias. As hipertrigliceridemias classificam-se quanto à gravidade em leves a moderadas (triglicérides > 200-499 mg/dL) e graves (acima de 500 mg/dL) ou muito graves (> 885 mg/dL, ou > 1000 mg/dL). Quando a hipertrigliceridemia se associa à elevação do LDL-colesterol e/ou à redução do HDL-colesterol, existe risco aumentado de eventos cardiovasculares. No entanto, nas formas graves de hipertrigliceridemia, a pancreatite e as dores abdominais recorrentes são as principais complicações. Estudos prospectivos observacionais, de randomização mendeliana e de intervenção terapêutica mostram não apenas a associação entre marcadores lipídicos e risco de doença cardiovascular, mas podem também evidenciar moléculas que sejam alvos terapêuticos no tratamento de dislipidemias e na redução do risco de eventos cardiovasculares. O tratamento das hipertrigliceridemias tem como objetivos a redução imediata do risco de pancreatite em pacientes com hipertrigliceridemias graves (> 1000 mg/dL) e redução do risco cardiovascular global nas formas leves a moderadas. Dieta restrita em gorduras e carboidratos simples, restrição de álcool, e o uso de fibratos isolados ou associados a ácidos graxos ômega-3 e ácido nicotínico são as principais opções terapêuticas. No entanto, as formas genéticas, que incluem as quilomicronemias familiares, são pouco responsivas à associação de fármacos, havendo necessidade de novas terapias para seu controle


Plasma concentrations of triglycerides are considered biomarkers of circulating triglyceride-rich lipoproteins and their remnants. Mild to moderate hypertriglyceridemia may be secondary to other metabolic disorders, environmental factors, drugs, or polygenic factors. On the other hand, severe forms of hypertriglyceridemia are generally monogenic and the result of six defective genes. Hypertriglyceridemia can be exacerbated by non-genetic factors. It can be classified, according to severity, as mild to moderate (triglycerides >200-499 mg/dL), severe (> 500 mg/dL) or very severe (> 885 mg/dL, or > 1000 mg/dL). When hypertriglyceridemia is associated with LDL-cholesterol elevation and/or a reduction in HDL-cholesterol, there is an increased risk of cardiovascular events. However, in severe forms of hypertriglyceridemia, pancreatitis and recurrent abdominal pain are the main complications. Prospective observational studies, Mendelian randomization studies and intervention studies have not only demonstrated the association between lipid markers and cardiovascular risk, but can also identify molecules as therapeutic targets in the treatment of dyslipidemias and reduction of pancreatitis and cardiovascular risk. Treatment of hypertriglyceridemia has two main objectives: to immediately reduce the risk of pancreatitis in patients with severe hypertriglyceridemia (> 1000 mg/dL), and to reduce global cardiovascular risk in mild to moderate forms. A diet that is low in fat and simple carbohydrates, with alcohol intake, and the use of fibrates, either alone or combined with omega-3 fatty acids, and niacin are the best therapeutic options. However, severe genetic hypertriglyceridemia, including familial chylomicronemia, are less responsive to drug therapy, even in combination, and require new strategies for control of dyslipidemia


Subject(s)
Humans , Male , Female , Therapeutics/methods , Hypertriglyceridemia/complications , Hypertriglyceridemia/blood , Pancreatitis/complications , Cholesterol, HDL/analysis , Cholesterol, HDL/blood , Cholesterol, LDL/analysis , Cholesterol, LDL/blood
6.
Rev. bras. cardiol. (Impr.) ; 25(4): 267-275, jul.-ago. 2012. tab
Article in Portuguese | LILACS | ID: lil-652615

ABSTRACT

Fundamentos: O consumo de grande quantidade de bebidas alcoólicas associa-se a alterações no sistemacardiovascular. A utilização da razão triglicerídeo/HDL-C (TG/HDL-C) apresenta-se como forte marcadoraterogênico. Objetivos: Estabelecer o perfil lipídico e razão TG/HDL-C de alcoolistas crônicos e comparar comindivíduos não alcoolistas. Métodos: Estudo de caso-controle compreendendo 50 indivíduos alcoolistas crônicos e 50 indivíduos não alcoolistas do mesmo sexo correspondente e idadessemelhantes. Foram analisadas variáveis referentes às condições socioeconômicas e de estilo de vida,antropometria e perfil lipídico de ambos os grupos, além da pressão arterial do grupo de alcoolistas. Com os resultados de triglicerídeo e HDL-C foi possível o cálculo da razão TG/HDL-C. Resultados: Com relação aos dados socioeconômicos e de estilo de vida não houve diferenças em relação à prática de atividade física e comorbidades. Quanto àantropometria, o grupo alcoolista apresentou valores menores de IMC, circunferência da cintura e razãocintura/estatura. Sobre o perfil lipídico e razão TG/HDL-C não houve diferença entre os grupos, apenas em relação ao HDL-C. A razão TG/HDL-C apresentouassociação com o IMC e razão cintura/estatura no grupo dos alcoolistas crônicos e com o IMC, circunferência da cintura, razão cintura/estatura e índice de conicidade no grupo dos não alcoolistas.Conclusão: O grupo de alcoolistas crônicos estudado apresentou melhor perfil bioquímico e razão TG/HDL-Cem comparação ao grupo de não alcoolistas.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Alcoholism/therapy , Cholesterol, HDL/analysis , Lipase/analysis , Triglycerides/analysis , Case Reports , Risk Factors
7.
Article in English | IMSEAR | ID: sea-157422

ABSTRACT

Background: Pattern of dyslipidemia is found to be different in type-1 & type-2 diabetes mellitus(DM). Dyslipidemic pattern and its correlation with glycated hemoglobin in both types of diabetes mellitus has been well studied and might be informative to the diagnostic,therapeutic & prognostic aspects of diabetes mellitus. AIM: To study the lipid profile by using direct method for High Density Lipoprotein-Cholesterol (HDLC) & Low Density Lipoprotein-Cholesterol(LDL-C) estimation, and glycated hemoglobin(GHb) in type-1DM & type-2 DM. Material and Methods: fifty each already diagnosed patients of type-1 and type-2 diabetes mellitus along with fifty control were studied for lipid profile using direct method for Low Density Lipoprotein-Cholesterol (LDL-C) & High Density Lipoprotein-Cholesterol (HDLC) estimation and glycated hemoglobin status. Statistical Analysis: we used student t-test and Pearson’s correlation coefficient to find the statistical significance. Result: serum concentration of glycated hemoglobin and all the parameters of lipid profile except HDL-C were increased while HDL-C concentration decreased in both the types of DM as compared to that of control. Conclusion: dyslipidemia is more prominent in type-2 DM than that in type-1 DM . Glycemic control is poorer & its correlation with lipid profile is stronger in type-2 DM as compared to type-1 DM.


Subject(s)
Cholesterol, HDL/analysis , Cholesterol, HDL/blood , Cholesterol, LDL/analysis , Cholesterol, LDL/blood , Diabetes Mellitus, Type 1 , Diabetes Mellitus, Type 2 , Dyslipidemias/analysis , Dyslipidemias/blood , Dyslipidemias/diagnosis , Glycated Hemoglobin A/analysis , Glycated Hemoglobin A/blood , Humans , Lipids/analysis , Lipids/blood
8.
Acta bioquím. clín. latinoam ; 46(1): 31-37, mar. 2012. graf, tab
Article in Spanish | LILACS | ID: lil-639598

ABSTRACT

Tomando en cuenta que aún no existe una metodología estándar de rutina para la determinación del colesterol de lipoproteínas de baja densidad (LDL-c) se decidió evaluar su determinación analítica utilizando tres técnicas: determinación enzimática homogénea, precipitación con sulfato de polivinilo y fórmula de Friedewald. Fueron procesadas 98 muestras de suero a las cuales se les determinó triglicéridos (TG), colesterol total (CT), colesterol de lipoproteínas de alta densidad (HDL-c) y colesterol de lipoproteínas de baja densidad (LDL-c). Los valores promedio de CT fueron 194,46 ± 43,54 mg/dL, HDL-c 51,12 ± 12,36 mg/dL y TG 132,88 ± 76,93 mg/dL. Aun cuando el análisis de regresión mostró una buena correlación entre los valores de LDL-c, los resultados indicaron una diferencia estadísticamente significativa en los mismos cuando los niveles de TG superaron los 200 mg/dL. La misma se observó principalmente entre el método de precipitación y la fórmula de Friedewald, siendo los valores significativamente más bajos en esta última (LDL-c por precipitación: 141,3 ± 26,2 mg/dL; LDL-c por fórmula de Friedewald: 110,1 ± 35,4 mg/dL). De la misma manera se vio afectada la proporción de individuos clasificados según su riesgo coronario. Es necesario comparar las técnicas aplicadas en este estudio con la cuantificación beta para evaluar cuál tiene un mayor nivel de exactitud.


Considering that there is still no standard methodology for routine determination of low density lipoprotein (LDL-c) it was decided to evaluate their analytical determination using three techniques: homogeneous enzymatic determination, polyvinyl sulphate precipitation and Friedewald formula. Ninety-eight serum samples were processed; triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-c) and LDL-c were determined. Mean total cholesterol was 194.46 ± 43.54 mg/dL, HDL-C was 51.12 ± 12.36 mg/dL and TG was 132.88 ± 76.93 mg/dL. Although regression analysis showed a good correlation between LDL-c, the results showed a statistically significative difference in them when TG levels exceeded 200 mg/dL. It was mainly observed in the precipitation method and the Friedewald formula, the latter values being significantly lower (LDL-C by precipitation: 141.3 ± 26.2 mg/dL, LDL-C by the Friedewald formula: 110, 1 ± 35.4 mg/dL). Moreover, this difference affected the proportion of individuals classified according to their coronary risk. It is necessary to compare the techniques applied in this study with beta quantification to assess which has a higher level of accuracy.


Levando em consideragao que ainda nao existe uma metodologia padrao de rotina para a determinagao do colesterol de lipoproteínas de baixa densidade (LDL-c) se decidiu avaliar sua determinagao analítica utilizando tres técnicas: determinagao enzimática homogénea, precipitagao com sulfato de polivinil e fórmula de Friedewald. Foram processadas 98 amostras de soro as quais lhes foi determinado triglicerídeos (TG), colesterol total (CT), colesterol de lipoproteínas de alta densidade (HDL-c) e colesterol de lipoproteínas de baixa densidade (LDL-c). Os valores médios de CT foram 194,46 ± 43,54 mg/dL, HDL-c 51,12 ± 12,36 mg/dL e TG 132,88 ± 76,93 mg/dL. Inclusive quando a análise de regressao mostrou uma boa correlagao entre os valores de LDL-c, os resultados indicaram uma diferenga estatisticamente significativa nos mesmos quando os niveis de TG superaram os 200 mg/dL. A mesma se observou principalmente entre o método de precipitagao e a fórmula de Friedewald, sendo os valores significativamente mais baixos nesta última (LDL-c por precipitagao: 141,3 ± 26,2 mg/dL; LDL-c por fórmula de Friedewald: 110,1 ± 35,4 mg/dL). Da mesma maneira se viu afetada a proporgao de indivíduos classificados conforme seu risco coronariano. É necessário comparar as técnicas aplicadas neste estudo com a quantificagao beta para avaliar qual é que tem maior nível de exatidao.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Laboratory and Fieldwork Analytical Methods/methods , Cholesterol, LDL/analysis , Cholesterol, LDL/blood , Cholesterol, HDL/analysis , Enzymes/blood , Risk Measurement Equipment , Triglycerides/blood
9.
Int. j. morphol ; 29(4): 1449-1454, dic. 2011. ilus
Article in Spanish | LILACS | ID: lil-627031

ABSTRACT

El envejecimiento humano es un proceso complejo y multifactorial que involucra aspectos cognitivos, sociales y físicos. El objetivo de este estudio fue determinar valores de algunos patrones antropométricos y fisiológicos y comparar el efecto de la actividad física, de estos patrones en población adulta mayor. Cien adultos mayores en edades a partir de los 60 años participaron de este estudio. En esta población se procedió a medir peso, talla y calcular el índice de masa corporal (IMC), además se obtuvieron registros de la capacidad vital y el consumo máximo de oxígeno. Luego a través de muestra sanguínea se determinó hematocrito y hemoglobina. La población se categorizó en rangos de edades y se separó según género. Posteriormente por encuesta simple de actividades, se separaron en personas activas y sedentarias. Los resultados obtenidos muestran que el IMC en mujeres activas y sedentarias presenta niveles de sobrepeso y obesidad, en varones activos solo a partir de los 70 años se observan valores de normalidad. El colesterol en damas y varones activos presentan valores bajo los 240mg/L y la población sedentaria sobre estos valores. Los registros de hemoglobina son significativamente mayores en población activa (12,3mg/dL a 14,2 mg/dL). Los patrones de espirometría muestran registros muy bajos en esta población en estudio. Se concluye que los patrones antropométricos y fisiológicos de esta población en estudio muestra mejores registros en adultos mayores activos.


The aim of this study was to determine anthropometric and physiological patterns and compare the effect of physical activity in older adults from Arica, Chile. One hundred elderly aged from 60 years on, participated in this study. In this population, we proceeded to measure weight, height and calculated body mass index (BMI) and also obtained records of vital capacity and maximal oxygen consumption. Then through blood samples, hematocrit and haemoglobin were determined. The population was categorized in age ranges and separated by gender. Then by simple questionnaire of activities, they were separated into active and sedentary older adults. The results obtained indicate that the active population has a better record than the sedentary population, both in women as well as in men. When analized according to sex, similar results were observed. Spirometry records of the entire study population are very low. We conclude that physical activity is an important factor inthe quality of life of people in the so-called third age, supporting theories of an active and successful aging. The study also reaffirms the behavior of the adult population over 60 years is in reality a complex and multifactorial phenomenon.


Subject(s)
Humans , Male , Female , Middle Aged , Aged, 80 and over , Aging , Anthropometry , Body Mass Index , Public Health , Activities of Daily Living , Body Weight , Chile , Vital Capacity/physiology , Cholesterol/analysis , Data Collection , Cholesterol, HDL/analysis , Hematocrit , Hemoglobins/analysis , Prevalence , Sedentary Behavior , Spirometry , Overweight/epidemiology
10.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 21(2 supl A): 8-12, abr.-jun. 2011. tab
Article in Portuguese | LILACS | ID: lil-597367

ABSTRACT

O estresse físico a que são submetidos nadadores pode promover alterações no perfil lipídico de jovens atletas. O objetivo do presente estudo foi verificar as alterações ocorridas no perfil lipídico de 15 atletas de natação (23,42 ± 3,5 anos, 79,12 ± 10,6 kg de peso corporal, 187,5 ± 12,3 cm de estatura e 10,2 ± 4,5% de gordura corporal), submetidos a 12 semanas de treinamento físico (aeróbico e força). As concentrações séricas de lipídios foram determinadas com o uso de técnicas enzimáticas colorimétricas e foram observadas alterações nas concentrações do colesterol total (Δ% = 14,6%, p≤ 0,05), LDL-C (Δ% = 23,54%, p≤ 0,05), HDL-C (Δ% = 10,8%, p≤ 0,05) e triglicerídeos (Δ% = -22%, p≤ 0,01). Em conclusão, o período específico de 12 semanas proporcionou reduções no nível de triglicerídeos e aumentos nos valores de HDL-C, LDL-C e colesterol total. Entretanto, apesar dessas mudanças, todas as variáveis do perfil lipídico destes atletas permaneceram dentro da classificação ótima ou desejável.


Subject(s)
Humans , Male , Female , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Cholesterol/analysis , Lipids/analysis , Swimming/education , Exercise , Risk Factors , Triglycerides/analysis
11.
Article in English | WPRIM | ID: wpr-152846

ABSTRACT

Various synthetic progestogens that are used as contraceptives have been reported to influence lipid and lipoprotein fractions differently. Depo-medroxyprogesterone acetate (DMPA), a synthetic progestogen, is used by Nepalese women as a contraceptive agent. Our study aims to determine the effects of long-term use of DMPA on lipid metabolism. We performed this study on 60 healthy Nepalese women who had been using DMPA for more than 2 yr and age- and weight-matched control subjects who were not using hormonal contraceptives. Fasting blood samples were collected from the subjects for the estimation of total cholesterol (TC) and triglyceride (TG) levels, and the levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were estimated using the Friedewald's equation. TC and LDL-C levels in DMPA users were significantly higher than those in non-users. Our study concluded that DMPA use induces lipid metabolism changes that can increase the risk of cardiovascular diseases.


Subject(s)
Adult , Cardiovascular Diseases/etiology , Cholesterol/blood , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Contraceptive Agents, Female/adverse effects , Female , Humans , Lipid Metabolism/drug effects , Medroxyprogesterone Acetate/adverse effects , Nepal , Risk Factors , Triglycerides/blood
12.
Rev. chil. cardiol ; 29(2): 208-213, ago. 2010. ilus
Article in Spanish | LILACS | ID: lil-577267

ABSTRACT

Resumen: Introducción: La respuesta terapéutica a estatuías se ve influenciada por factores como la edad, género y etnicidad. Con respecto a esto, el background genético de la población chilena es predominantemente Amerindio, definido por la presencia de haplogrupos Amerindios A, B, C y D de DNA mitocondrial (mtDNA). Así, el objetivo del estudio fue evaluar la potencial asociación entre la presencia de haplogrupos Amerindios de mtDNA y niveles de lípidos en individuos chilenos hipercolesterolémicos tratados con Atorvastatina. Métodos: Un total de 42 individuos en dos centros de salud del sur de Chile fueron incluidos en el estudio. En el grupo de pacientes se evaluó la presencia de haplogrupos Amerindios de mtDNA por PCR-RFLP, además de la cuantificación de Colesterol Total, Triglicéridos, Colesterol-HDL y Colesterol-LDL, antes y después del tratamiento con Atorvastatina (10 mg/día). Resultados: El 88.1 por ciento de los sujetos presentó algún haplogrupo Amerindio, no observándose diferencias en los niveles de lípidos pre- tratamiento de acuerdo al haplogrupo. Interesantemente, individuos de haplogrupo B presentaron niveles mayores de Colesterol Total (B: 254 +/- 30 mg/dl v/s C: 213 +/- 48 mg/dl, D: 230 +/- 50 mg/dl; p= 0.0319) y Colesterol-LDL (B: 157 +/- 34 mg/dl v/s C: 118 +/- 45 mg/dl, D: 135 +/- 42 mg/dl; p=0.0344) post-tratamiento. Conclusiones: El haplogrupo B se asocia a niveles mayores de lípidos post-tratamiento en pacientes tratados con Atorvastatina. Estos hallazgos sugieren por primera vez, que la presencia de haplogrupo B de mtDNA determinaría una menor respuesta al tratamiento con Atorvastatina en individuos chilenos con background genético amerindio.


Background: Therapeutic response to statins is influenced by age, gender and ethnicity. The genetic background of the Chilean population is predominantly Amerindian, defined by the presence of mitochondrial DNA (mtDNA) Amerindian haplogroups A, B, C and D Amerindian haplogroups and serum lipid levéis in hypercholesterolemic Chilean subjects receiving atorvastatin Methods: 42 subjects from southern Chile were included. The presence of mtDNA Amerindian haplogroups was evaluated by PCR-RFLP; in addition, total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were measured before and after treatment with atorvastatin 10 mg/day. Aim: to evaluate a possible association of mtDNA. Ameridian haplogroups and serum lipid levels in hypercholesterolemic Chilean subjects receiving atorvastatin. Result: 88.1 percent of subjects exhibited some Amerindian haplogroup. No relation of lipid levels with haplogroups was observed before treatment. Interestingly, haplogroup B individuals had higher levels of total cholesterol compared to other haplogroups after treatment (haplogroup B : 254 +/- 30 mg/dl; C : 213 +/- 48 mg/dl; D : 230 +/- 50 mg/dl, p=0.0319). Corresponding levels for LDL-cholesterol after treatment in the three groups were 157 +/- 34,118 +/-45 and 135 +/-42 mg/ di, respectively, p=0.0344. Conclusion: Compared to other haplogroups, haplogroup B is associated to higher levels of lipids after treatment with atorvastatin. For the first time, these findings suggest that the presence of mtDNA haplogroup B determines a dimished response to atorvastatin in Chilean subjets with an Amerindian genetic background.


Subject(s)
Humans , Male , Female , DNA, Mitochondrial/genetics , Heptanoic Acids/therapeutic use , Anticholesteremic Agents/therapeutic use , Haplotypes , Hypercholesterolemia/genetics , Hypercholesterolemia/drug therapy , Pyrroles/therapeutic use , DNA, Mitochondrial/analysis , Chile , Genetic Predisposition to Disease , Genotype , Cholesterol, HDL/analysis , Indians, South American/genetics , Cholesterol, LDL/analysis , Polymerase Chain Reaction , Polymorphism, Restriction Fragment Length , Triglycerides/analysis
13.
J. bras. patol. med. lab ; 45(4): 285-294, ago. 2009. tab
Article in Portuguese | LILACS | ID: lil-531777

ABSTRACT

INTRODUÇÃO E OBJETIVOS: Ensaios de diferentes procedências para avaliação das dislipidemia podem resultar em variações significativas nos resultados obtidos e consequente conduta inadequada pelo clínico. O estudo objetivou comparar resultados laboratoriais de colesterol total (CT), triglicérides (TG), colesterol da lipoproteína de alta densidade (HDL-C), colesterol da lipoproteína de baixa densidade (LDL-C), apolipoproteína A-1 (Apo A-1), apolipoproteína B (Apo B) e lipoproteína (a) (Lp[a]) e índices lipídicos (não-HDL-C, CT/HDL-C, LDL-C/HDL-C, TG/HDL-C e Apo B/HDL-C) de pacientes hipertensos e/ou diabéticos diagnosticados. MÉTODOS: Foram utilizados conjuntos reativos, e os respectivos analisadores Gold Analisa, Dia Sys (CCX - Abbott), Dade Behring (Nefelômetro BN 100) e Roche (COBAS Integra 400), para verificar a reprodutibilidade dos resultados obtidos. Participaram 99 pacientes (36 do sexo masculino e 63 do feminino). Comparando os resultados, verificamos que: todas as médias obtidas dos constituintes lipídicos apresentaram diferença significativa; número semelhante de pacientes apresentou níveis séricos elevados de CT, TG, Lp(a) e Apo A-1. O HDL-C, o LDL-C e a Apo B apresentaram discordância, assim como os índices de CT/LDL-C, LDL-C/HDL-C e TG/HDL-C. Para não-HDL-C e ApoB/HDL, houve semelhança no número de pacientes com valores não recomendados. Em consequência da diferença, em relação ao LDL-C, a decisão da conduta terapêutica poderá ser inadequada, enquanto o não-HDL-C, além de evidenciar partículas aterogênicas, apresentou número de hipertensos com valores séricos não referendados semelhantes, independente da metodologia e do equipamento utilizado. CONCLUSÃO: No grupo de hipertensos analisados, o não-HDL-C se caracterizou um importante fator de correção interensaios de parâmetros lipídicos. E sua associação à relação Apo B/HDL-C pode ser um fator adicional em relação às condutas hipolipemiantes a serem adotadas.


INTRODUCTION AND OBJECTIVES: Different assays to evaluate dyslipidemia may show significant variations in the obtained results and a consequent inappropriate clinical approach may be adopted. This study aimed to compare the results of total cholesterol (CT), triglycerides (TG), HDL-C, Apo A1, Apo B, lipoprotein (a) and lipidic indexes (not-HDL-C, CT/HDL-C, LDL-C/HDL-C, TG/HDL-C and Apo B/HDL-C) of hypertensive and/or diabetic patients. METHODS: The following reactive kits and respective analyzers were applied to verify the reproducibility of results: Gold Analisa, DiaSys (CCX-ABBOTT), Dade Behring (Nephelometer BN 100) and Roche (COBAS Integra 400). Ninety nine patients (36 male and 63 female gender) were investigated. Comparing the results, we observed that all mean numbers of lipid constituents showed a significant difference. A similar number of patients had high CT, TG, Lp (a) and Apo A-1 serum levels. There was also disagreement in HDL-C, LDL-C, ApoB, CT/LDL-C, LDL-C/HDL-C and TG/HDL-C indexes. For not-HDL-C and ApoB/HDL, there was similarity in the number of patients with not recommended values. As a consequence of this difference, the choice of therapeutic approach may be inappropriate as to LDL-C levels, whereas Not-HDL-C not only showed atherogenic particles but also a number of hypertensive patients with similar not recommended serum values, regardless of the methodology and the equipment used. CONCLUSION: In the analyzed group of hypertensive patients, not-HDL-C was an important inter assay correction factor of lipidic parameters. The association with Apo B/HDL-C relation may be an additional factor as to the choice of hypolipemiant treatments.


Subject(s)
Humans , Male , Female , Dyslipidemias/diagnosis , Immunoassay/methods , Apolipoprotein A-I/analysis , Apolipoproteins B/analysis , Apoprotein(a)/analysis , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Cholesterol/analysis , Immunoassay/instrumentation , Reproducibility of Results , Triglycerides/analysis
14.
Rev. argent. endocrinol. metab ; 45(5): 195-205, oct.-dic. 2008. tab
Article in Spanish | LILACS | ID: lil-641943

ABSTRACT

Objetivo: En el hipotiroidismo tanto clínico como subclínico se han descripto alteraciones en el metabolismo lipídico, entre ellas la disminución de colesterol de lipoproteínas de alta densidad (HDL-C). Considerando el rango normal de TSH entre 0.4-3.0 μUI/ml y valores normales altos entre 2.0 y 3.0 μUI/ml, nosotros investigamos la hipótesis de que niveles normales altos de TSH e insulinorresistencia (IR) se encuentran relacionados con HDL-C bajo en mujeres, en ausencia de otros factores concurrentes. Materiales y métodos: Estudiamos en un estudio transversal a 200 mujeres sanas, edad 18-50 años, eutiroideas, normotensas, con anticuerpos antiperoxidasa (ATPO) negativos, no diabéticas, premenopáusicas, IMC 18.0-25.0 Kg/m2, perímetro de cintura ≤ 88 cm; perímetro de cuello ≤ a 35 cm. Se las dividió en 4 grupos, cada uno compuesto por 50 mujeres: Grupo 1 (G1) TSH ≥ 2μU/ml, IR; grupo 2 (G2) TSH ≥ 2μU/ml, no IR; grupo 3 (G3): TSH 0,40 a 1,99 μU/ml, IR; Grupo 4 (G4) TSH 0,40 a 1,99 μU/ml, no IR. Se les midió lípidos, TSH, T4 total y libre (T4L), glucosa e insulina basal y posprandial, índices HOMA y QUICKI y volumen tiroideo (VT). Resultados: Observamos que en el G1 el nivel de HDL-C (46,7± 8,1 mg/dl) fue significativamente menor que en los restantes grupos. (vs G2: 56,8 ± 8,6 mg/dl; vs G3: 51,2 ± 7,6 mg/dl y vs G4: 56,5 ± 9,1 mg/dl. (p<0,01). La frecuencia de pacientes con HDL-C bajo en G1 fue significativamente mayor que en los restantes grupos (vs G2: OR 1,83, IC: 1,23-2,70; vs G3: OR 1,49, IC: 1,04-2,31; vs G4: OR 1,90, IC: 1,29-2,81) . No encontramos diferencias significativas en los niveles de HDL-C entre los restantes grupos. Conclusiones: Observamos en mujeres eutiroideas con TSH normal alta insulinorresistentes, sin otros factores concurrentes, niveles de HDL-C significativamente más bajos que en mujeres no insulinorresistentes y que en mujeres insulinorresistentes con TSH normal baja.


It has been described abnormalities in lipid metabolism in clinical and subclinical hypothyroidism, including the reduction of high-density lipoprotein cholesterol (HDL-C). Considering the normal range for TSH between 0.4-3.0 uUI / ml and high-normal values between 2.0 and 3.0 uUI / ml, we investigated the hypothesis that in euthyroid women, high-normal TSH levels and insulin resistance (IR) are associated with low HDL-C. We observed in euthyroid women with high-normal TSH and insulin resistance, without other factors, a significantly lower level of HDL-C than in non-insulin or insulin resistance women with low-normal TSH.


Subject(s)
Humans , Female , Adolescent , Adult , Middle Aged , Insulin Resistance/physiology , Hypothyroidism/etiology , Cholesterol, HDL/analysis , Reference Values , Thyrotropin/analysis , Lipid Metabolism/physiology , Hypothyroidism/prevention & control , Lipoproteins, HDL/analysis , Cholesterol, HDL/biosynthesis
15.
Arq. bras. endocrinol. metab ; 52(2): 334-339, mar. 2008.
Article in Portuguese | LILACS | ID: lil-481002

ABSTRACT

Com a intensificação do controle glicêmico no tratamento do diabetes melito tipo 1 (DM1), houve uma mudança progressiva das causas de mortalidade com destaque para a DCV. A identificação de fatores de risco, como a dislipidemia, tornou-se de grande importância para minimizar o risco de complicações crônicas micro e macrovasculares. As diretrizes para prevenção de doença coronariana em diabetes, geralmente, fazem referência ao diabetes melito tipo 2 (DM2), com pouca recomendação específica para o DM1. Definir alvos terapêuticos ou indicação de intervenção farmacológica é mais controverso nesse tipo de diabetes, em virtude da faixa etária desses pacientes. O presente estudo busca destacar a importância de estabelecer o diagnósti-co da dislipidemia nesse grupo de pacientes e instituir terapêutica adequa- da e precoce, objetivando alcançar as metas estabelecidas para reduzir o perfil lipídico aterogênico desses pacientes.


With the intensive glycemic control in the therapy of type 1 diabetes mellitus (T1DM) patients, cardiovascular disease has been the main cause of mortality. Identification of risk factors, such as dyslipidemia is considered of great importance in terms of avoiding chronic micro and macro vascular complications. The statements for prevention of coronary artery disease in diabetes are generally are related do type 2 diabetes mellitus and little attention is paid to T1DM. Defining therapeutical targets and indications for treatment are more controversial in these patients due to their young ages. The present study aims to emphasize the importance of establishing the diagnosis of dyslipidemia in this group of patients as well as indicate the appropriate and early treatment, in order to reach the targets of treatment and reduce the atherogenic lipid profile.


Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Humans , Male , Young Adult , Diabetes Mellitus, Type 1/drug therapy , Diabetic Angiopathies/drug therapy , Dyslipidemias/drug therapy , Hypolipidemic Agents/therapeutic use , Blood Glucose/analysis , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Diabetes Mellitus, Type 1/complications , Diabetic Angiopathies/etiology , Diabetic Angiopathies/prevention & control , Dyslipidemias/diagnosis , Dyslipidemias/etiology , Monitoring, Physiologic , Risk Factors , Treatment Outcome , Young Adult
16.
J. bras. patol. med. lab ; 43(2): 95-101, abr. 2007.
Article in Portuguese | LILACS | ID: lil-450965

ABSTRACT

O processo de formação da placa aterosclerótica inicia-se na infância e progride lentamente até a vida adulta, quando ocorrerão as manifestações clínicas da doença. O objetivo deste trabalho foi realizar um estudo da concentração plasmática de colesterol total (CT), colesterol da lipoproteína de baixa densidade (LDL-C), triglicéride (TG) e colesterol da lipoproteína de alta densidade (HDL-C) numa população na faixa etária de 2 a 19 anos, de ambos os sexos, atendida no ambulatório do Hospital Universitário Antônio Pedro (HUAP). Os dados dos prontuários foram obtidos entre dezembro/2004 e janeiro/2006 e as concentrações plasmáticas foram correlacionadas com os fatores de risco para dislipidemia. As dosagens foram feitas no Laboratório de Bioquímica Clínica do HUAP. Os níveis plasmáticos do CT, LDL-C, TG e HDL-c foram maiores no sexo feminino do que no masculino e este fato é compatível com a literatura. A média dos valores de TG, CT, LDL-C e HDL-C observada na população estudada mostrou-se elevada para esses parâmetros, principalmente em pacientes que apresentam doenças, como síndrome nefrótica, lúpus eritematoso sistêmico (LES) e diabetes mellitus (DM). Este trabalho reforça a tese da necessidade de utilização, no Brasil, de estudos sobre os intervalos de valores de referência do perfil lipídico nesta faixa etária e também sobre o perfil dos níveis desses lípides na população considerada sadia.


Atherosclerotic plaques form early in childhood and progress slowly until adult life, when clinical manifestations show. The goal of this study was to analyze the concentrations in plasma of total cholesterol, LDL-cholesterol (LDL-C), triglycerides (TG) and HDL-cholesterol (HDL-C) in a group of children of both sexes and up to 19 years of age, who are attending at the University Hospital Antônio Pedro (HUAP). Patient admission sheets between December 2004 and January 2006 were analyzed for dyslipidemic risk factors, and correlated with the respective lipid plasma concentrations, determined at the Laboratory of Clinical Chemistry (HUAP). The plasma levels of total cholesterol, LDL-C, TG and HDL-C in female patients were higher than in male patients, suggesting the influence of sexual maturation as described in the literature. The mean concentrations of total cholesterol, LDL-C, TG and HDL-C were elevated in the investigated group, mainly in patients presenting with other pathologies, such as nephrotic syndromes, diabetes mellitus and systemic lupus erythematosus. Our results suggest that, in Brazil, the reference value interval of lipoprotein levels should be investigated more thoroughly in this age group, as well as in children who are considered healthy.


Subject(s)
Humans , Child , Adolescent , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Cholesterol/analysis , Dyslipidemias , Reference Values , Triglycerides/analysis , Atherosclerosis , Hypercholesterolemia
17.
Rev. chil. cardiol ; 26(4): 437-443, 2007. ilus, tab
Article in Spanish | LILACS | ID: lil-499074

ABSTRACT

Introducción: El receptor scavenger clase B tipo I (SR-BI) es un elemento clave en el metabolismo de las HDL, donde su expresión ejerce un importante efecto anti-aterogénico controlando la fase hepática del transporte reverso de colesterol. Así, el estudio de la modulación de la expresión de SR-BI permitiría el desarrollo de nuevas alternativas farmacológicas para el tratamiento de la ateroesclerosis. Objetivo: La meta de nuestro estudio fue determinar el efecto de la triiodotironina (T3) y el glucagón sobre el metabolismo del colesterol HDL y la expresión hepática de SR-BI en el ratón, evaluando simultáneamente su impacto sobre el colesterol total y lipoproteico plasmático y la secreción biliar de colesterol. Métodos: Se utilizaron ratones C57BL/6 tratados con T3 (30 nmol/kg/día) o glucagón (80 µg/día) más los respectivos grupos controles. Después del tratamiento, los animales se anestesiaron para recolección de bilis, plasma y tejido hepático. Los niveles totales de colesterol plasmático y biliar fueron medidos por métodos enzimáticos. El colesterol lipoproteico plasmático se evaluó por fraccionamiento cromatográfico del plasma y medición enzimática del colesterol en cada fracción. La expresión hepática de SR-BI se cuantificó mediante western blot. Resultados: El uso de T3 o glucagón disminuyeron significativamente el colesterol plasmático total y aumentaron el colesterol biliar con respecto al grupo control correspondiente. Las fracciones de colesterol VLDL, LDL y HDL disminuyeron en ambos grupos tratados, con un mayor efecto observado en la fracción HDL. La administración de ambas hormonas aumentaron significativamente los niveles hepáticos de SR-BI. Conclusión: Los resultados establecen que T3 y glucagón disminuyen el colesterol plasmático, predominantemente de tipo HDL, y aumentan la secreción de colesterol biliar en el ratón, probablemente como consecuencia del incremento en la expresión hepática...


Introduction: The scavenger receptor class B type I (SR-BI) plays a key role in the metabolism of high-density lipoprotein (HDL) cholesterol. Its expression has an important anti-atherogenic effect by controlling the hepatic phase of the reverse cholesterol transport pathway in vivo. Thus, the study of the modulation of SR-BI expression may allow the development of new pharmacologic approaches for treatment of atherosclerotic cardiovascular disease. Objective: The goal of this study was to determine the effect of triiodothyronine (T3) and glucagon on HDL metabolism and hepatic expression of SR-BI in mice, evaluating also the impact in total and lipoprotein cholesterol as well as biliary cholesterol secretion. Methods: C57BL/6 mice were treated with T3 (30 nmol/kg/día) or glucagon (80 µg/día) in comparison to appropriate control groups. After treatment, bile, plasma and hepatic tissue were collected for analysis. Total plasma and biliary cholesterol levels were measured by enzymatic methods. Lipoprotein cholesterol was also measured enzymatically after chromatographic separation of plasma samples. The hepatic expression of SR-BI protein was quantified by western blotting. Results: The use of T3 or glucagon significantly decreased total plasma cholesterol levels and increased of biliary cholesterol concentrations compared to control groups. Levels of VLDL, LDL and HDL cholesterol were reduced in both treatment groups, with a more important effect observed in the HDL fraction. Both treatments increased hepatic SR-BI protein levels. Conclusions: These results show that T3 and glucagon decrease plasma cholesterol levels, particularly in HDL, and increase biliary cholesterol secretion in mice, probably as a consecuence of higher hepatic expression of SR-BI, which may have led to facilitated HDL cholesterol transport from plasma into bile.


Subject(s)
Animals , Mice , Cholesterol, HDL/metabolism , Glucagon/pharmacology , Liver/metabolism , Scavenger Receptors, Class B , Triiodothyronine/pharmacology , Blotting, Western , Bile/chemistry , Cholesterol, HDL/analysis , Cholesterol/analysis , Fluorescent Antibody Technique , Glucagon/administration & dosage , Liver , Receptors, Lipoprotein , Triiodothyronine/administration & dosage
18.
Article in English | IMSEAR | ID: sea-90562

ABSTRACT

OBJECTIVE: The main objectives of the study were to evaluate the effect of dietary fat on plasma lipoprotein(a) [Lp(a)] levels and to study the potential of Lp(a) as a more reliable marker for CAD compared to other lipids and lipoproteins. METHODS: Twenty CAD patients and 20 healthy controls were recruited for the study. Their fasting plasma Lp(a) levels and complete lipid profile were assayed. The fat intake was calculated using 24 hours dietary recall method. The patients and controls were each divided into two subgroups: Group A consuming dietary fat > 30% and Group B consuming dietary fat < or = 30% of the total kilo-calories/day. RESULTS: Results indicated that plasma Lp(a), total serum cholesterol (TC), tryglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and LDL-C/HDL-C ratio of CAD patients were significantly higher than the controls. High fat intake was found to be associated with higher plasma Lp(a) levels (p<0.05) in patients only. No significant correlation was found between Lp(a) levels and other conventional lipoproteins. CONCLUSION: The lack of correlation between Lp(a) and other lipoproteins indicates its potential as an independent risk factor for CAD. High fat intake led to higher plasma Lp(a) levels in patients; hence it would be worthwhile to evaluate the effect of quality and quantity of fat intake on plasma Lp(a) levels in a larger sample size.


Subject(s)
Adult , Age Distribution , Biomarkers/analysis , Case-Control Studies , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Coronary Disease/epidemiology , Dietary Fats/adverse effects , Female , Humans , Incidence , India/epidemiology , Lipoprotein(a)/analysis , Male , Middle Aged , Probability , Reference Values , Risk Assessment , Severity of Illness Index , Sex Distribution , Survival Rate
19.
Article in English | IMSEAR | ID: sea-93209

ABSTRACT

Data suggest that lipid fractions other than total cholesterol, i.e. serum triglycerides (TG) and high-density lipoprotein (HDL) cholesterol are important for the pathogenesis of atherosclerosis. A combination of hypertriglyceridemia, low levels of HDL-cholesterol and high levels of small dense low-density lipoprotein, termed as "atherogenic dyslipidemia', is particularly seen in Asian Indians. Although precise reason for such dyslipidemia is unknown, genetic predisposition and characteristic body composition (excess truncal subcutaneous fat and intraabdominal fat) may be important contributors. A common interface between such body composition and dyslipidemia in Asian Indians is high tendency to develop insulin resistance, more than the other ethnic groups. The general guidelines for the management of dyslipidemia in Asian Indians should be according to National Cholesterol Education Program, Adult Treatment Panel III. However, optimal management requires consideration of ethnic-specific dietary, lifestyle and management factors to formulate individual treatment guidelines.


Subject(s)
Adult , Age Distribution , Aged , Asians/statistics & numerical data , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Female , Humans , Hyperlipidemias/diagnosis , Incidence , India/epidemiology , Insulin Resistance/ethnology , Male , Middle Aged , Risk Assessment , Severity of Illness Index , Sex Distribution , Survival Rate
20.
Indian J Pediatr ; 2002 Sep; 69(9): 755-9
Article in English | IMSEAR | ID: sea-79420

ABSTRACT

OBJECTIVE: Considering the importance of primary prevention of Cardiovascular Disease (CVD) from childhood, especially in children with high family risk for premature atherosclerosis, and also the importance of oxidized LDL in the process of atherosclerosis, the main metabolites of ox-LDL i.e. Malondialdehyde (MDA) and Conjugated diene (CDE) have been measured in children of high risk families and compared with a control group. METHODS: Children and adolescents (6-18 years) of parents with premature myocardial infarction (MI < or = 55 y in men and < or = 65 y in women), were selected as the case group. The control group included neighbors of the case group matched for age and socioeconomic status. All samples have been selected by simple random sampling. Both the case and control groups were divided in two subgroups: those with a total cholesterol and/or LDL-C > or = 95th centile and those with normal lipid levels. Each subgroup consisted of 32 subjects, so 128 subjects were studied (64 in the case and 64 in the control group). MDA and CDE were measured by spectrophotometry using molar absorbivity. Data were analyzed by SPSSv10/Win software using ANOVA, Bonferroni, Scheffe-Duncan, Tukey-HSD, and the Student's t-test. RESULT: The mean MDA value in the case and control groups was significantly different (1.84 +/- 0.43 vs. 1.67 +/- 0.41 micromol/L, p=0.03), but this difference was not significant regarding the mean CDE level (0.50 +/- 0.05 vs. 0.47 +/- 0.04 micromol/L, p>0.05). The mean MDA level in the case group with hyperlipidemia was significantly higher than that in the case group without hyperlipidemia (1.985 +/- 0.516 vs. 1.690 +/- 0.366, micromol/L, P=0.02) and also higher than control group with or without hyperlipidemia (1.985 +/- 0.516 vs. 1.720 +/- 0.389, 1.615 +/- 0.429 micromol/L respectively, P<0.05). The mean CDE level in the case group with hyperlipidemia was significantly higher than the case group without hyperlipidemia (0.542 +/- 0.034 vs. 0.494 +/- 0.049 micromol/L, P=0.04) and higher than the control group with or without hyperlipidemia (0.542 +/- 0.034 vs. 0.464 +/- 0.051, 0.484 +/- 0.048 micromol/L respectively, p<0.05). In case boys with hyperlipidemia, the mean MDA (2.03 +/- 0.2 micromol/L) and the mean of CDE (0.56 +/- 0.04 micromol/L) was significantly higher than other subgroups (P<0.05). CONCLUSION: Considering the increased susceptibility of LDL to oxidation in children with high family risk for premature CVD, special attention should be paid to consumption of foods and seasoning containing antioxidants from childhood especially in high risk families.


Subject(s)
Adolescent , Age Distribution , Aged , Analysis of Variance , Cardiovascular Diseases/diagnosis , Case-Control Studies , Child , Cholesterol, HDL/analysis , Cholesterol, LDL/analysis , Female , Genetic Predisposition to Disease , Humans , Lipoproteins, LDL/analysis , Male , Middle Aged , Myocardial Infarction/diagnosis , Pedigree , Probability , Prospective Studies , Reference Values , Risk Assessment , Risk Factors , Sensitivity and Specificity , Sex Distribution , Spectrophotometry
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