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Mediterr J Pharm Pharm Sci ; 2(1): 91-99, 2022.
Article in English | AIM, AIM | ID: biblio-1364046


By January 2020, severe acute respiratory syndrome coronavirus-2 has spread internationally to a pandemic that mainly targets the respiratory system. The relevant infectious disease has been identified as coronavirus disease-2019 (COVID-19) by World Health Organization and declared as a global pandemic. In Libya, National Center for Disease Control reported the first case of coronavirus disease-2019 on 24th March, 2020. The authorities decided to close borders and activate designated treatment centers to deal with COVID19 cases and contain the outbreak of SARS-COV-2. This study aimed to assess and evaluate the pharmaceutical situation of medications used in pharmacological management of hospitalized COVID-19 patients in Tripoli, Libya. Three WHO availability indicators were selected to be studied and reported. A comprehensive list of medicines used in the management of hospitalized COVID-19 patients was constructed after reviewing and comparing seven national and international pharmacological management protocols and guidelines for hospitalized COVID-19 patients. This comparison revealed that nearly 50 medications are intended for use in COVID-19 inpatient pharmacological management. They all agreed about the use of three medications, representing one from each main class. This list was used to cross check their availability at the chosen designated COVID-19 treatment center. This study proved that local treatment center's protocol is more in line with international guidelines than the national treatment guideline. The later was issued on March 2020. The Libyan National Essential Medicines' List contained 25 out of 50 medications of the comprehensive list based on the last update in April 2019. This study recommends that national treatment guidelines and National Essential Medicines' list require updating. Not all medications used in COVID-19 inpatient management were available in local treatment centers, although, the Emergency Management Department of Ministry of Health in Libya is responsible for the supply of the required medical supplies and medications to the COVID-19 treatment centers.

Humans , Male , Female , Clinical Protocols , Severe Acute Respiratory Syndrome , COVID-19 , Inpatients , Drug Therapy , SARS-CoV-2 , Hospitalization
Hematol., Transfus. Cell Ther. (Impr.) ; 43(4): 417-423, Oct.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1350799


ABSTRACT Introduction: Daratumumab is a CD38-targeting monoclonal antibody with established efficacy and safety in patients with relapsed or refractory multiple myeloma (RRMM). We report results of an early access protocol (EAP) of daratumumab monotherapy for RRMM in a cohort of Brazilian patients. Methods: Patients with RRMM and ≥3 prior lines of therapy, including a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD), or who were double refractory to both a PI and IMiD received daratumumab, 16 mg/kg, intravenously weekly for 8 weeks, biweekly for 16 weeks, and every 4 weeks thereafter until disease progression, unacceptable toxicity, loss of clinical benefit, or study conclusion or if daratumumab became available with reimbursement. Results: Forty-nine patients received ≥1 dose of daratumumab. The median (range) duration of treatment was 6.4 (0.3-11.8) months, with a median (range) of 8 (1-13) treatment cycles. Grade 3/4 treatment-emergent adverse events (TEAEs) were reported in 38.8% of patients, most frequently neutropenia and pneumonia (10.2% each). Seven (14.3%) patients discontinued treatment due to TEAEs; 3 patients discontinued due to daratumumab-related TEAEs. Serious TEAEs occurred in 38.8% of patients. Infusion-related reactions were reported in 25 (51.0%) patients, were primarily grade 1/2, and the majority (23 patients) occurred during the first infusion. Twenty (40.8%) patients achieved a partial response or better; median progression-free survival was 8.25 (95% confidence interval, 5.55-17.54) months. Conclusion: In this EAP, daratumumab monotherapy in Brazilian patients showed a safety and efficacy profile consistent with clinical studies of daratumumab monotherapy in patients with heavily pretreated RRMM. identifier: NCT02477891.

Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Multiple Myeloma/drug therapy , Clinical Protocols , Antibodies, Monoclonal
Rev. Méd. Inst. Mex. Seguro Soc ; 59(6): 500-509, 01-dic-2021. grap, map
Article in Spanish | LILACS | ID: biblio-1355278


Introducción: la diabetes mellitus (DM) y las enfermedades del corazón, entre las que se incluye la hipertensión arterial sistémica (HTA), se han posicionado entre las primeras causas de mortalidad en México, lo que plantea retos importantes para las diferentes instituciones de salud. Objetivo: analizar la tendencia espacio-temporal de DM e HTA con base en las detecciones realizadas en unidades de primero y segundo nivel del Instituto Mexicano del Seguro Social (IMSS), durante el periodo 2004-2019. Material y métodos: estudio ecológico en el que se calcularon las tasas de detección de ambos padecimientos por mil derechohabientes según año, trienio y representación. La tendencia espacio-temporal se analizó mediante estadística espacial utilizando Sistemas de Información Geográfica. Resultados: de 2004 a 2019 hubo 9 399 889 y 11 862 069 detecciones en promedio de DM e HTA, respectivamente. Referente al primer padecimiento, la tasa de deteccion osciló de 203.4 (2004) a 384.4 (2019) por mil derechohabientes, cuya tendencia aumentó en Tamaulipas. Mientras que la HTA disminuyó de 1140.2 (2004) a 352 (2019) detecciones por mil derechohabientes en Veracruz Sur y Tamaulipas, respectivamente. Conclusiones: la tendencia espacio-temporal observada puede contribuir a organizar y orientar, según su representación y nivel de atención, los programas institucionales, protocolos de atención, guías de práctica clínica y demás instrumentos de políticia pública disponibles en el IMSS para mejorar la detección oportuna, atención, control y acceso a medicamentos para DM e HTA.

Background: Diabetes Mellitus (DM) and heart diseases, which include Systemic Arterial Hypertension (SAH), have been positioned as the two main causes of mortality in Mexico, which represents important challenges for the different health institutions. Objective: To analyze the spatio-temporal trend of DM and SAH based on the detections made in first and and second level units of the Instituto Mexicano del Seguro Social, during the period 2004-2019. Material and methods: Ecological study in which detection rates of both diseases were calculated per 1,000 persons according to year, triennium and representation. The spatio-temporal trend was analyzed by spatial statistics using Geographic Information Systems. Results: During 2004-2019 therere were 9 399 889 and 11 862 069 detections on average of DM and SAH, respectively. Regarding DM, the detection rate ranged from 203.4 (2004) to 384.4 (2019) per 1000 persons, this trend increased in Tamaulipas. While SAH decreased from 1140.2 (2004) to 352 (2019) per 1000 persons in Veracruz Sur and Tamaulipas, respectively. Conclusions: The observed spatio-temporal trend can contribute to organizing and guiding, according to representation and level of care, institutional programs, integrated care protocols, clinical practice guidelines and other public policy instruments available at the Instituto Mexicano del Seguro Social to improve early detection, care, control and access to medications for DM and SAH.

Humans , Male , Female , Clinical Protocols , Diabetes Mellitus , Health Services Accessibility , Health Services Research , Hypertension , Social Security , Epidemiology , Cause of Death , Geographic Information Systems , Mexico
Hematol., Transfus. Cell Ther. (Impr.) ; 43(4): 476-481, Oct.-Dec. 2021. tab, ilus
Article in English | LILACS | ID: biblio-1350816


ABSTRACT Introduction: We performed cost-effectiveness and cost-utility analyses of the modified International Consortium on Acute Promyelocytic Leukemia protocol in Mexico for the treatment of acute promyelocytic leukemia Acute Promyelocytic Leukemia. Methods: We performed a three-state Markov analysis: stable disease (first line complete response [CR]), disease event (relapse, second line response and CR) and death. The modified IC-APL protocol is composed of three phases: induction, consolidation and maintenance. Cost and outcomes were used to calculate incremental cost-effectiveness ratios (ICERs); quality-adjusted life-years were used to calculate incremental cost-utility ratios (ICURs). Results: The CR was achieved in 18 patients (90%), treated with the IC-APL protocol as the first-line option; one patient (5%) died in induction, another one never achieved CR (5%); of the 18 patients that achieved CR, 1 relapsed (5.5%). The median treatment cost of the IC-APL protocol was $21,523 USD. The average life-year in our study was 7.8 years, while the average quality-adjusted life-year (QALY) was 6.1 years. When comparing the ICER between the IC-APL and the all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) protocols, we found the different costs of $6497, $19,133 and $17,123 USD in Italy, the USA and Canada, respectively. In relation to the ICUR, we found the different costs to be $13,955 and $11,979 USD in the USA and Canada, respectively. Conclusion: Taking into account the similar response rates, lower cost and easy access to the modified IC-APL regimen, we consider it a cost-effective and cost-utility protocol, deeming it the treatment of choice for our population.

Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Leukemia, Promyelocytic, Acute/diagnosis , Leukemia, Promyelocytic, Acute/drug therapy , Tretinoin/therapeutic use , Clinical Protocols , Cost-Benefit Analysis
Femina ; 49(12): 648-657, 20211130. ilus
Article in Portuguese | LILACS | ID: biblio-1358200


O transplante de medula óssea (TMO) é um procedimento indicado para o tratamento de doenças hematológicas, que afetam muitas mulheres jovens. O aperfeiçoamento dos cuidados durante o TMO proporciona altos índices de cura e de sobrevida. No entanto, pode deixar sequelas em vários órgãos e sistemas, entre eles o sistema reprodutor e os órgãos genitais, impactando negativamente a qualidade de vida das receptoras do TMO. O objetivo desta publicação foi realizar uma revisão narrativa sobre o tema e propor um protocolo assistencial que torne acessível os cuidados relacionados à saúde sexual e reprodutiva a esse grupo especial de mulheres, baseado em dados clínicos de um ambulatório de assistência ginecológica às mulheres transplantadas no Hospital Amaral Carvalho, em Jaú, no interior de São Paulo.(AU)

Bone marrow transplantation (BMT) is indicated for the treatment of hematological diseases which affect many young women. The improvement of care during BMT procedures provides higher cure and survival rates. however, it can cause sequelae in various organs and systems, including the reproductive system and genitals, negatively impacting quality of life. The purpose of this publication is to present a narrative review related to this theme and to propose a healthcare protocol that allows sexual and reproductive care in this special group of patients, based on the clinical experience of a gynecological outpatient clinic at the Amaral Carvalho Hospital, in Jaú (SP) which specifically care for these women.(AU)

Humans , Female , Postoperative Complications , Bone Marrow Transplantation/adverse effects , Clinical Protocols , Risk Factors , Immunosuppression/adverse effects , Primary Ovarian Insufficiency/physiopathology , Female Urogenital Diseases/physiopathology , Graft vs Host Disease/physiopathology
Femina ; 49(12): 699-704, 20211130. ilus
Article in Portuguese | LILACS | ID: biblio-1358207


A perda gestacional de repetição (PGR) é definida classicamente como três perdas consecutivas antes de 20 semanas de gestação. Ela afeta aproximadamente 3% dos casais que tentam conceber, quando se consideram pelo menos duas perdas, e cerca de 1%, quando acima de três perdas. A PGR está associada a diferentes fatores causais. Algumas mulheres não terão nenhuma anormalidade identificável nos protocolos investigativos atuais. O aborto pode causar doenças mentais, tais como depressão e ansiedade, e ser responsável por sentimentos como medo, raiva e culpa. Embora existam intervenções já estabelecidas para pacientes com perda gestacional com fator causal determinado, não existe nenhum tratamento comprovadamente efetivo em mulheres com perda gestacional inexplicada. O oferecimento do chamado Tender Loving Care pode levar a melhores resultados gestacionais nessas pacientes. Este artigo irá fazer uma revisão sobre os aspectos psíquicos em PGR e o cuidado suportivo que poderá ser realizado nessas pacientes.(AU)

Recurrent pregnancy loss (RPL) is classically defined as three consecutive losses before 20 weeks of gestation. It affects approximately 3% of couples who try to conceive, when considering at least two losses, and about 1%, when considering three or more. RPL is associated with different causal factors. Some women will have no identificable abnormalities in current investigative protocols. Abortion can cause mental illness, such as depression and anxiety, and be responsible for feelings like fear, anger and guilt. Although there are interventions already established for patients with pregnancy loss with a determined causal factor, there is no proven effective treatment for women with unexplained pregnancy loss. The offer of the so-called Tender Loving Care can lead to better pregnancy results in these patients. This article will review the psychic aspects of recurrent pregnancy losses and the supportive care that can be performed in these patients.(AU)

Humans , Female , Pregnancy , Cognitive Behavioral Therapy/statistics & numerical data , Abortion, Habitual/psychology , Abortion, Habitual/therapy , Stress, Psychological/psychology , Stress, Psychological/therapy , Clinical Protocols , Stress Disorders, Traumatic/psychology , Stress Disorders, Traumatic/therapy , Depression/psychology , Depression/therapy , Patient Health Questionnaire
São Paulo; SES/SP; nov. 2021. 56 p. tab, ilus, graf, mapas.
Non-conventional in Portuguese | ColecionaSUS, LILACS, ColecionaSUS, SES-SP, CONASS, SESSP-CTDPROD, SES-SP, SESSP-ACVSES | ID: biblio-1344584
Enferm. foco (Brasília) ; 12(7, supl 1): 61-66, out. 2021.
Article in Portuguese | LILACS, BDENF | ID: biblio-1337560


Objetivo: contextualizar a vivência profissional de enfermeiros na perspectiva da Sistematização da Assistência de Enfermagem, com foco no fortalecimento da Atenção Primária à Saúde e na ampliação do acesso resolutivo e de qualidade. Método: trata-se de estudo descritivo, com abordagem qualitativa, do tipo relato de experiência, sobre vivência de enfermeiros na implantação participativa dos protocolos de enfermagem no município de Florianópolis ­ Santa Catarina, Brasil. Resultados: a experiência profissional compreendeu as seguintes fases: Definição de Stakeholders, Alinhamento Conceitual, Aplicação de Questionário - levantamento da expertise dos profissionais, Estabelecimento de Premissas Gerais, Validação dos Protocolos, Monitoramento e Avaliação do Processo, e Disposições Gerais. Trata-se de uma prática com possibilidade de replicação, sustentável na medida em que a Comissão Permanente de Enfermagem se fortalece e agrega profissionais com visão de rede e com foco no cuidado ao paciente. Conclusão: observou-se o avanço da atuação do enfermeiro e a ampliação do acesso ao serviço de saúde. Além disso, o uso dos protocolos auxilia na tomada de decisão, com foco na segurança do paciente e respaldo ao profissional com base em princípios éticos da profissão. (AU)

Objective: To contextualize the professional experience of nurses from the perspective of Systematization of Nursing Care, with a focus on strengthening Primary Health Care and expanding access to resolving and quality. Methods: This is a descriptive study, with a qualitative approach, of the experience report type, on the experience of nurses in the participatory implementation of nursing protocols in the city of Florianópolis ­ Santa Catarina, Brazil. Results: The experience reported comprised the following phases: Definition of Stakeholders, Conceptual Alignment, Application of a Questionnaire - to survey the expertise of professionals, Establishment of Premises, Validation of Protocols, Monitoring and Evaluation of the Process, General Provisions. It is a practice with great possibility of replication. It is sustainable insofar as the Nursing Commission is strengthened, bringing together professionals with a network vision and a focus on patient care. Conclusion: It was observed the advance of the nurse's work and the expansion of access to the health service. In addition, the use of protocols can help in decision making, focusing on patient safety and support for the professional based on ethical principles of the profession. (AU)

Objetivo: Contextualizar la experiencia profesional del enfermero desde la perspectiva de la Sistematización de la Atención de Enfermería, con un enfoque en el fortalecimiento de la Atención Primaria de Salud y la ampliación del acceso a la resolución y la calidad. Métodos: Se trata de un estudio descriptivo, con abordaje cualitativo, del tipo relato de experiencia, sobre la experiencia de enfermeras en la implementación participativa de protocolos de enfermería en la ciudad de Florianópolis - Santa Catarina, Brasil. Resultados: La experiencia reportada comprendió las siguientes fases: Definición de Grupos de Interés, Alineación Conceptual, Aplicación de un Cuestionario - relevar la pericia de los profesionales, Establecimiento de Premisas, Validación de Protocolos, Seguimiento y Evaluación del Proceso, y Disposiciones Generales. Es una práctica con gran posibilidad de replicación. Es sostenible en la medida en que se fortalece la Comisión de Enfermería, que reúne a profesionales con visión de red y enfoque en la atención al paciente. Conclusión: Se observó el avance en el rol del enfermero y la ampliación del acceso al servicio de salud. Además, el uso de protocolos puede ayudar en la toma de decisiones, enfocándose en la seguridad del paciente y el apoyo al profesional basado en principios éticos de la profesión. (AU)

Nursing , Primary Health Care , Clinical Protocols , Advanced Practice Nursing , Health Services Accessibility
Enferm. foco (Brasília) ; 12(7, supl 1): 110-114, out. 2021.
Article in Portuguese | LILACS, BDENF | ID: biblio-1337857


Objetivo: descrever a experiência da implantação de protocolos de Enfermagem para a ampliação do acesso na atenção primária à saúde, mediante a qualificação da prática clínica do Enfermeiro. Método: estudo descritivo em formato de relato de experiência. O cenário de estudo é o Estado Santa Catarina, tendo como população alvo as Secretarias Municipais de Saúde do Estado. O Coren/SC firmou parceria com a Secretaria Municipal de Saúde de Florianópolis para utilização dos Protocolos de Enfermagem, criando um Programa de Adesão para os municípios. Resultados: Desde a implantação, o programa recebeu 225 solicitações de adesão dentre os 295 municípios catarinenses. Atingiu um total de 135 municípios com os protocolos de enfermagem implantados e 1.708 Enfermeiros capacitados. A oferta de Consultas de Enfermagem onde não havia atendimento do Enfermeiro, ampliação do acesso dos pacientes, com redução significativa de filas de espera, além do aumento das consultas de Enfermagem e resolutividade das mesmas. Conclusão: Os Protocolos de Enfermagem constituem-se como ferramenta primordial para a efetivação do modelo de Atenção Primária no Estado e como inovação e diferencial para as pessoas atendidas. A adesão aos protocolos permite a valorização e o protagonismo da Enfermagem na Atenção Primária. (AU)

Objective: To describe the experience of implementing nursing protocols to expand access to primary health care, through the qualification of nurses' clinical practice. Methods: Descriptive study in experience report format. The study setting is the State of Santa Catarina, with the Municipal Health Secretariats of the State as the target population. Coren/SC signed a partnership with the Municipal Health Department of Florianópolis for the use of Nursing Protocols, creating an Adhesion Program for the municipalities. Results: Since its implementation, the program has received 225 requests for membership among the 295 municipalities in Santa Catarina. It reached a total of 135 municipalities with implemented nursing protocols and 1,708 trained nurses. The offer of Nursing Appointments where there was no care provided by the Nurse, expansion of access for patients, with a significant reduction in waiting lines, in addition to the increase in Nursing appointments and their resoluteness. Conclusion: The Nursing Protocols constitute a primordial tool for the realization of the Primary Care model in the State and as an innovation and differential for the people served. Adherence to protocols allows the enhancement and protagonism of Nursing in Primary Care. (AU)

Objetivo: Describir la experiencia de implementación de protocolos de enfermería para ampliar el acceso a la atención primaria de salud, a través de la calificación de la práctica clínica del enfermero. Métodos: Estudio descriptivo en formato de relato de experiencia. El escenario del estudio es el Estado de Santa Catarina, con las Secretarías Municipales de Salud del Estado como población objetivo. Coren / SC firmó una alianza con el Departamento de Salud Municipal de Florianópolis para el uso de Protocolos de Enfermería, creando un Programa de Adhesión para los municipios. Resultados: Desde su implementación, el programa ha recibido 225 solicitudes de membresía entre los 295 municipios de Santa Catarina. Llegó a un total de 135 municipios con protocolos de enfermería implementados y 1,708 enfermeras capacitadas. La oferta de Citas de Enfermería donde no hubo atención por parte de la Enfermera, ampliación del acceso de los pacientes, con una reducción significativa de las filas de espera, además del aumento de las citas de Enfermería y su resolución. Conclusión: Los Protocolos de Enfermería constituyen una herramienta primordial para la realización del modelo de Atención Primaria en el Estado y como innovación y diferencial para las personas atendidas. La adherencia a los protocolos permite la potenciación y protagonismo de la Enfermería en Atención Primaria. (AU)

Nursing , Primary Health Care , Clinical Protocols , Health Services Accessibility
Enferm. foco (Brasília) ; 12(7, supl 1): 147-152, out. 2021. graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1341916


Objetivo: relatar a implantação e os impactos advindos dos Protocolos de Enfermagem no contexto da Atenção Primária à Saúde do município de Jaraguá do Sul, Santa Catarina,. Método: Trata de um estudo descritivo do tipo relato de experiência. Resultados: O Fluxo de implantação foi desenvolvido com a instituição de uma Comissão de Implantação, Monitoramento e Avaliação dos Protocolos. Após a ampla divulgação, sensibilização e publicitação para a população do município, iniciou-se a implantação nas Unidades Básicas de Saúde, gerando impacto direto nos 12.765 pacientes que aguardavam a primeira consulta médica. Com a implantação dos protocolos, em um mês, houve redução de 74,71% (9.538 pacientes) e em sete meses, houve o resultado prospectado de zerar as filas de primeira consulta da Atenção Primária. Considerações Finais: a implementação dos Protocolos de Enfermagem, propicia mais segurança para a atuação dos enfermeiros da rede municipal e reduz a fila de espera na Atenção Primária. A consulta de Enfermagem e a prescrição de exames e medicamentos essenciais para a população, bem como o processo de acolhimento nas unidades de saúde, foram incorporados na rotina de trabalho dos enfermeiros, proporcionando maior resolutividade das demandas de saúde. (AU)

Objective: To report the implementation and impacts arising from the Nursing Protocols in the context of Primary Health Care in the municipality of Jaraguá do Sul, Santa Catarina. Methods: This is a descriptive study of the experience report type. Results: The Implementation Flow was developed with the institution of a Protocol Implementation, Monitoring and Evaluation Committee. After wide dissemination, awareness and publicity for the population of the city, the implementation of Basic Health Units began, generating a direct impact on the 12,765 patients who were waiting for their first medical appointment. With the implementation of the protocols, in one month, there was a reduction of 74.71% (9,538 patients) and in seven months, there was the prospected result of clearing the queues for the first consultation in Primary Care. Conclusion: The implementation of Nursing Protocols provides more security for the work of nurses in the municipal network and reduces the waiting list in Primary Care. Nursing consultation and the prescription of tests and essential medications for the population, as well as the reception process in health units, were incorporated into the nurses' work routine, providing greater resolution of health demands. (AU)

Objetivo: Reportar la implementación e impactos derivados de los Protocolos de Enfermería en el contexto de la Atención Primaria de Salud en el municipio de Jaraguá do Sul, Santa Catarina. Métodos: Se trata de un estudio descriptivo del tipo relato de experiencia. Resultados: El Flujo de Implementación fue desarrollado con la institución de una Comisión de Implementación, Monitoreo y Evaluación del Protocolo. Luego de una amplia difusión, sensibilización y publicidad para la población de la ciudad, se inició la implementación de Unidades Básicas de Salud, generando un impacto directo en los 12.765 pacientes que esperaban su primera cita médica. Con la implementación de los protocolos, en un mes hubo una reducción del 74,71% (9.538 pacientes) y en siete meses, se logró el resultado esperado de despejar las colas para la primera consulta en Atención Primaria. Conclusion: La implementación de Protocolos de Enfermería brinda mayor seguridad para el trabajo de los enfermeros en la red municipal y reduce la lista de espera en Atención Primaria. La consulta de enfermería y la prescripción de pruebas y medicamentos esenciales para la población, así como el proceso de recepción en las unidades de salud, se incorporaron a la rutina de trabajo de las enfermeras, brindando una mayor resolución de las demandas de salud. (AU)

Nurse's Role , Primary Health Care , Clinical Protocols , Public Health
Rev. bras. ginecol. obstet ; 43(9): 690-698, Sept. 2021. tab, graf
Article in English | LILACS | ID: biblio-1351773


Abstract Objective Infection and exposure of the implant are some of the most common and concerning complications after implant-based breast reconstruction. Currently, there is no consensus on the management of these complications. The aim of the present study was to review our cases and to present a clinical protocol. Methods We conducted a retrospective review of consecutive patients submitted to implant-based breast reconstruction between 2014 and 2016. All patients were managed according to a specific and structured protocol. Results Implant exposure occurred in 33 out of 277 (11.9%) implant-based reconstructions. Among these, two patients had history of radiotherapy and had their implant removed; Delayed reconstruction with a myocutaneous flap was performed in both cases. Signs of severe local infection were observed in 12 patients, and another 5 presented with extensive tissue necrosis, and they were all submitted to implant removal; of them, 8 underwent reconstruction with a tissue expander, and 2, with a myocutaneous flap. The remaining 14 patients had no signs of severe infection, previous irradiation or extensive tissue necrosis, and were submitted to primary suture as an attempt to salvage the implant. Of these, 8 cases (57.1%) managed to keep the Conclusion Our clinical protocol is based on three key points: history of radiotherapy, severe infection, and extensive tissue necrosis. It is a practical and potentially-reproducible method of managing one of the most common complications of implant-based breast reconstruction.

Resumo Objectivo Infecção e exposição da prótese são algumas das complicações mais comuns e preocupantes após reconstrução da mama com implantes. Atualmente, ainda não há consenso quanto ao manejo destas complicações. O objetivo deste estudo foi o de revisar os casos da nossa instituição e apresentar um protocolo clínico. Métodos Realizou-se uma revisão retrospectiva de todos os casos consecutivos submetidos a reconstrução mamária imediata com prótese entre 2014 e 2016. Todos os casos foram conduzidos de acordo com um protocolo específico e estruturado. Resultados A exposição do implante ocorreu em 33 de 227 reconstruções (11,9%). Dentre estas, duas pacientes tinham histórico de radioterapia, e foram submetidas a remoção da prótese e posterior reconstrução com retalho miocutâneo. Sinais de infecção local grave foram observados em 12 pacientes, e, em 5, necrose extensa de tecido, e todas foram submetidas a remoção dos implantes; destas, 8 foram recons truídas com expansor, e 2, com retalho miocutâneo. As 14 pacientes remanecentes não haviam sido submetidas previamente à radioterapia, não tinham sinais de infecção, nem necrose extensa; portanto, foram submetidas a sutura primária em uma tentativa de salvar a prótese. Dessas, 8 pacientes (57,1%) conseguiram manter os implantes originais. Conclusão Nosso protocolo clínico é baseado em três pontos principais: histórico de radioterapia, infecção grave, e necrose extensa de tecido. Ele constitui um método prático e potencialmente reprodutível de manejo de uma das complicações mais comuns da reconstrução mamária com implantes.

Humans , Female , Breast Neoplasms/surgery , Mammaplasty/adverse effects , Breast Implants/adverse effects , Postoperative Complications/surgery , Postoperative Complications/etiology , Postoperative Complications/epidemiology , Tissue Expansion Devices/adverse effects , Clinical Protocols , Retrospective Studies
Rev. cuba. pediatr ; 93(3): e1572, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347544


Introducción: La presentación clínica de la enfermedad provocada por el SARS-CoV-2 es heterogénea. Los pacientes pueden ser asintomáticos o tener una enfermedad leve de las vías respiratorias superiores o desarrollar una neumonía grave que puede progresar al síndrome de dificultad respiratoria aguda y provocar la muerte. La fisiopatología de las formas graves de la enfermedad se caracteriza por una marcada hiperinflamación. Las terapias que modulan la respuesta inmunitaria pueden ser cruciales para tratar y prevenir este estado. El péptido CIGB-258, marca comercial Jusvinza, es una opción terapéutica para este propósito, por sus propiedades inmunomoduladoras. Objetivo: Describir la evolución clínica de un paciente pediátrico con neumonía grave por SARS-CoV-2, tratado con el péptido CIGB-258 Presentación del caso: Adolescente de 12 años con epilepsia refractaria, parálisis cerebral infantil y antecedentes epidemiológicos de contacto con paciente positivo a test confirmatorio de reacción en cadena de la polimerasa con transcriptasa inversa para SARS-CoV-2 que ocho días después del contacto, muestra evidencias clínicas, radiográficas y de laboratorio de neumonía grave por COVID-19. Dentro del protocolo terapéutico, recibió tratamiento con el péptido inmunomodulador CIGB-258, con una evolución favorable y egreso hospitalario. Conclusiones: El uso del péptido CIGB-258 en el tratamiento de la neumonía grave por COVID-19 en pediatría, podría contribuir a evitar la progresión hacia las etapas críticas de la enfermedad(AU)

Introduction: The clinical presentation of the disease caused by SARS-CoV-2 is heterogeneous. Patients may be asymptomatic or have mild upper respiratory tract disease, or develop severe pneumonia that can progress to acute respiratory distress syndrome and lead to death. The pathophysiology of severe forms of the disease is characterized by a marked hyperinflammation. Therapies that modulate the immune response can be crucial in treating and preventing this state. The CIGB-258 peptide, brand name Jusvinza, is a therapeutic option for this purpose, due to its immunomodulatory properties. Objective: Describe the clinical evolution of a pediatric patient with severe pneumonia due to SARS-CoV-2, and treated with the CIGB-258 peptide. Case Presentation: A 12-year-old adolescent with refractory epilepsy, infantile cerebral palsy, and an epidemiological history of contact with a patient positive to PCR confirmatory test for SARS-CoV-2 who, eight days after contact, shows clinical, radiographic, and laboratory evidence of severe pneumonia due to COVID-19. Within the therapeutic protocol, he received treatment with CIGB-258 immunomodulatory peptide, with a favorable evolution and hospital discharge. Conclusions: The use of CIGB-258 peptide in the treatment of severe pneumonia due to COVID-19 in pediatrics could contribute to prevent progression to the critical stages of the disease(AU)

Humans , Female , Child , Pneumonia/physiopathology , Respiratory Distress Syndrome, Newborn/etiology , SARS-CoV-2 , COVID-19/epidemiology , Clinical Evolution , Clinical Protocols
Rev. cuba. cir ; 60(3): e1090, 2021.
Article in Spanish | LILACS, CUMED | ID: biblio-1347385


Introducción: Los cirujanos pueden desempeñar un papel valioso en la realización de traqueostomía para apoyar a los equipos de cuidados críticos durante la pandemia global de la COVID-19. Objetivo: Diseñar un protocolo para realizar la traqueostomía en pacientes con la COVID-19. Métodos: Se realizó un estudio descriptivo durante el periodo de marzo a diciembre del año 2020 en el Hospital "Comandante Manuel Fajardo Rivero", de Santa Clara, Villa Clara. Se emplearon como métodos teóricos: el análisis-síntesis e inductivo-deductivo; y como empíricos: análisis documental, grupo nominal y el criterio de especialistas para la valoración del producto diseñado. Resultados: El protocolo fue estructurado en: título, propósito, normas organizativas institucionales, indicaciones, procedimiento de actuación y evaluación. Según el criterio de los especialistas consultados el protocolo diseñado, es pertinente, factible y válido. Conclusiones: Para el diseño del protocolo fue fundamental aplicar y adaptar cuidadosamente la mejor evidencia existente sobre la realización de la traqueostomía. Su estructura permite brindar la mejor atención al paciente con la COVID-19 al tiempo que protege al equipo quirúrgico(AU)

Introduction: Surgeons can play a valuable role in performing tracheostomy, as a support for critical care teams during the global COVID-19 pandemic. Objective: To design a protocol for performing the tracheostomy in patients with COVID-19. Methods: A descriptive study was carried out, during the period from March to December 2020, at Comandante Manuel Fajardo Rivero Hospital, in Santa Clara City, Villa Clara Province. The following theoretical methods were used: analysis-synthesis and inductive-deductive; as well as empirical ones: documentary analysis, nominal group and criteria of specialists for the evaluation of the designed product. Results: The protocol was structured into title, purpose, institutional organizational norms, indications, procedure of action and evaluation. According to the criteria of the specialists consulted, the designed protocol is pertinent, feasible and valid. Conclusions: For the design of the protocol, it was essential to apply and adapt, carefully, the best existing evidence on tracheostomy performance. Its structure allows to provide the best care to the patient with COVID-19 while protecting the surgical team(AU)

Humans , Tracheostomy/methods , Clinical Protocols , Critical Care/methods , Patient Care/adverse effects , COVID-19/etiology , Epidemiology, Descriptive
Av. enferm ; 39(3): 345-355, 01 de septiembre de 2021.
Article in Portuguese | LILACS, BDENF, COLNAL | ID: biblio-1291118


Objetivo: analisar a percepção dos enfermeiros sobre o protocolo de prevenção e tratamento de feridas utilizado na Atenção Primária à Saúde em Natal, Rio Grande do Norte, Brasil. Materiais e método: trata-se de um estudo exploratório com abordagem qualitativa. Foram entrevistadas 20 enfermeiras da Estratégia Saúde da Família, que fizeram uso regular do protocolo denominado Guia básico de prevenção e tratamento de feridas. Os instrumentos de coleta de dados foram questionário e observação direta. Os dados foram analisados pela técnica de análise temática de conteúdo. Resultados: emergiram duas categorias: Percepção sobre o protocolo, que foi subdividida em sistematização do tratamento de feridas, satisfação profissional e internalização da visão integral; Mudanças efetivadas com a implantação do protocolo, que esteve relacionada com a aquisição de novos conhecimentos, com o aumento do percentual de cura e com a satisfação do usuário. A utilização do protocolo orientou a condução do tratamento, minimizando o sofrimento físicopsíquico e os impactos socioeconômicos aos usuários e a seus familiares. Conclusões: a implantação do protocolo permitiu a padronização das ações assistenciais no tratamento de pessoas com feridas. Evidenciaram-se a satisfação e a segurança na conduta no manejo das lesões, com aceleração dos processos de cicatrização, o que promoveu maior cuidado em saúde. Sugere-se a potencialização da assistência humanizada às pessoas com feridas para a valorização dos enfermeiros. A assistência sistematizada pode contribuir para uma maior adesão ao tratamento e para o fortalecimento das práticas desenvolvidas no território

Objetivo: analizar la percepción de los profesionales en enfermería sobre el protocolo de prevención y tratamiento de heridas utilizado en la atención primaria de salud en Natal, Río Grande del Norte, Brasil. Materiales y método: estudio exploratorio de corte cualitativo en el que se realizaron entrevistas a 20 enfermeras que regularmente emplean el protocolo "Guía Básica para la Prevención y el Tratamiento de Heridas". Los instrumentos para la recolección de datos fueron un cuestionario y observación directa. Los datos se analizaron en función de la técnica de análisis de contenido temático. Resultados: surgieron dos categorías: Percepción sobre el protocolo, que se subdivide en sistematización del tratamiento de heridas, satisfacción profesional e internalización de la visión integral, y Cambios realizados con la implementación del protocolo, que se relaciona con la adquisición de nuevos conocimientos, un mayor porcentaje de curación y la satisfacción del usuario. El uso del protocolo orientó la realización del tratamiento, minimizando el sufrimiento físico y psicológico de los usuarios y los impactos socioeconómicos para estos y sus familias. Conclusiones: la implementación del protocolo permitió la estandarización de las acciones de atención en el tratamiento de lesiones cutáneas. La aceleración de los procesos de cicatrización permitió evidenciar satisfacción y seguridad frente al manejo de este tipo de lesiones, promoviendo así una mejor atención en salud. Se recomienda fortalecer el cuidado humanizado a los pacientes con heridas para la valoración de los profesionales en enfermería. La atención sistematizada puede contribuir a una mayor adherencia al tratamiento y al fortalecimiento de las prácticas en el territorio.

Objective: To examine the perception of nurses about the wound prevention and treatment protocol used in primary health care in Natal, Rio Grande do Norte, Brazil. Materials and method: Exploratory study with a qualitative approach. Twenty nurses who worked in the Family Health Strategy and regularly used the protocol called "Basic Guide for Wound Prevention and Treatment" were interviewed. Data collection instruments were a questionnaire and direct observation. The data were analyzed by the technique of thematic content analysis. Results: Two categories emerged from the analysis carried out: Perception about the protocol, which is subdivided into systematization of wound treatment, professional satisfaction, and internalization of integral vision, and Changes made with the implementation of the protocol, which is related to the acquisition of new knowledge, the increase in healing rates, and users' satisfaction. The adoption of the protocol guided the conduct of treatment, minimizing users' physical and psychological distress and the socioeconomic impacts for them and their families. Conclusions: The implementation of the protocol allowed the standardization of care actions in the treatment of skin lesions. The acceleration of healing processes derived in satisfaction and safety in the management of this type of lesions, thus promoting greater health care. The enhancement of a more humanized care to patients with wounds is suggested in order to better value nurses. Systematized care can contribute to greater adherence to treatment and the strengthening of practices developed in the Brazilian territory.

Humans , Primary Health Care , Wounds and Injuries , Clinical Protocols , Family Health , Community Health Nursing
Rev. Asoc. Odontol. Argent ; 109(2): 73-75, ago. 2021.
Article in Spanish | LILACS | ID: biblio-1348346


La pandemia de COVID-19 obligó a la odontología a in- corporar nuevos protocolos de atención clínica para evitar la contaminación y la transmisión viral en la cotidianeidad de la práctica profesional. De entre ellos, resulta de particular interés considerar la utilización de equipos de protección per sonal, sobre todo, en prácticas que requieren de tiempos de trabajo prolongados y extrema precisión (AU))

The COVID-19 pandemic forced dentistry to incorpo- rate new clinical care protocols to avoid contamination and viral transmission in daily professional practice. In par- ticular the use of personal protective equipment, especially in practices that require long working times and extreme precision (AU)

COVID-19 , Ergonomics , Argentina , Societies, Dental/standards , Clinical Protocols , Public Health Dentistry , Dentistry/standards , Personal Protective Equipment
Rev. Asoc. Odontol. Argent ; 109(2): 91-99, ago. 2021. ilus
Article in Spanish | LILACS | ID: biblio-1348398


Objetivo: Describir el tratamiento endodóncico de cuatro casos clínicos de reabsorción radicular desarrollada durante o tras un tratamiento ortodóncico. Casos clínicos: Después de la preparación y la desinfección de los conductos radiculares, estos fueron obturados por un tiempo prudencial con una medicación intraconducto de hidróxido de calcio, que luego fue reemplazada por MTA. Luego de un período de entre uno y cuatro años, según el caso, los tratamientos fueron evaluados clínica y radiográficamente. Los dientes que debieron ser extraídos fueron analizados histológicamente. Según la evolución clínica y radiográfica de los casos presentados, el uso inicial de hidróxido de calcio y su posterior reemplazo por MTA parecería ser un protocolo adecuado para completar el proceso de reparación de los tejidos apicales y perirradiculares en casos de reabsorciones radiculares provocadas por fuerzas ortodóncicas excesivas. Las enfermedades sistémicas deben ser tenidas en cuenta para la elección de la terapéutica (AU)

Aim: To describe the endodontic treatment of four clinical cases of permanent teeth suffering root resorption during or after orthodontic treatment. Clinical cases: Four clinical cases of permanent teeth with root resorption were endodontically treated. After the root canals were prepared and disinfected, they were medicated with calcium hydroxide. After an appropriate observation period, the canals were finally filled with MTA. The treatment outcomes were clinically and radiographically assessed at an interval between one to four years according to the clinical case. The histological findings of teeth that required extraction was also described. Our clinical and radiographic observations suggest that a temporary filling with calcium hydroxide and further obturation with MTA can provide a favorable intracanal environment for apical and periradicular tissue reparation. The clinician needs a full medical history to be aware of the systemic diseases in patients with root resorption that will be of importance for the proper selection of treatment (AU)

Humans , Male , Child , Adolescent , Orthodontics, Corrective/adverse effects , Root Canal Filling Materials , Root Resorption , Calcium Hydroxide , Periapical Tissue , Wound Healing/physiology , Clinical Protocols , Treatment Outcome , Tooth, Nonvital/diagnostic imaging
Ciênc. Saúde Colet ; 26(6): 2301-2310, jun. 2021. tab
Article in English | LILACS | ID: biblio-1278708


Abstract Diabetes mellitus (DM) is a chronic disease marked by elevated blood glucose levels. Controlling DM involves adequate diet, physical exercises, medicines and monitoring the blood glucose and glycated hemoglobin (HbA1c) levels. This was a retrospective study of the process of dispensing long-acting insulin analogues to users with diabetes (types 1 and 2) who were registered at high-cost public pharmacies in public health system in a southeast state of Brazil, that sought to evaluate the fulfillment of the criteria of all the clinical protocol to provide these analogs. Of the 987 users registered in the health service, 315 met the inclusion criteria for the study. The evaluation of the dispensing processes of the long-acting insulin analogues revealed that the inclusion, exclusion, and suspension criteria of the protocol related with these insulin analogues were in some extend only partially fulfilled. Additionally, there was no difference between the initial and final fasting glycemic and HbA1c levels. It is concluded that the established criteria for dispensing long-acting insulin analogues were partly fulfilled by pharmacies, compromising the rational use of these analogues. It can directly impact the cost of maintaining the public health service and users' health.

Resumo Diabetes mellitus (DM) é uma doença crônica marcada por níveis sanguíneos elevados de glicose. O controle do DM envolve dieta adequada, exercícios físicos, medicamentos e monitoramento dos níveis sanguíneos de glicose e de hemoglobina glicada (HbA1c). Trata-se de um estudo retrospectivo do processo de dispensação de análogos de insulina de ação prolongada a usuários com diabetes (tipos 1 e 2) cadastrados em farmácias públicas de alto custo do sistema público de saúde de um estado do Sudeste do Brasil, que buscou avaliar o cumprimento dos critérios do protocolo clínico para fornecimento desses análogos. Dos 987 usuários cadastrados no serviço de saúde, 315 preencheram os critérios de inclusão. A avaliação dos processos de dispensação dos análogos de insulina de ação prolongada revelou que os critérios de inclusão, exclusão e suspensão do protocolo dos análogos de insulina eram parcialmente cumpridos. Além disso, não houve diferença entre os níveis inicial e final de glicemia em jejum e HbA1c. Conclui-se que os critérios estabelecidos para dispensação de análogos de insulina de ação prolongada foram parcialmente cumpridos pelas farmácias, comprometendo o uso racional dos análogos. Os achados podem impactar diretamente no custo de manutenção do serviço público de saúde e na saúde do usuário.

Humans , Pharmacies , Diabetes Mellitus, Type 2 , Blood Glucose , Brazil , Clinical Protocols , Public Health , Retrospective Studies , Insulin, Long-Acting , Hypoglycemic Agents , Insulin