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1.
Rev. Ciênc. Méd. Biol. (Impr.) ; 20(1): 95-100, maio 5, 2021. tab, ilus
Article in Portuguese | LILACS | ID: biblio-1354841

ABSTRACT

Objetivo: analisar os efeitos do método Pilates sobre a força muscular respiratória em crianças com sintomas de asma. Metodologia: nesse estudo clínico foram avaliadas 17 crianças em idade escolar (09 a 12 anos), de ambos os sexos. Inicialmente responderam ao questionário International Study of Asthma and Allergies in Childhood (ISAAC), que avalia a prevalência de asma e doenças alérgicas em crianças e adolescentes. Assim, aquelas que obtiveram uma pontuação no ISAAC, com nota de corte igual ou superior a 5, foram incluídas no estudo. Após as crianças realizarem uma avaliação através do manovacuômetro, a fim de mensurar as pressões respiratórias máximas (PImáx e PEmáx) foi realizada uma avaliação antropométrica para verificar a massa corporal e a estatura. Como intervenção, as crianças participaram de um programa de exercícios com base no método Pilates 2 vezes por semana, com duração aproximada de 50 minutos cada sessão, durante 8 meses, totalizando 32 semanas. Resultados: Em relação às pressões, tanto a PImáx quanto a PEmáx aumentaram pós-intervenção. Conclusão: o estudo encontrou contribuições significativas do método Pilates sobre a força muscular respiratória (PImáx e PEmáx) de crianças com sintomas de asma. Desta forma, sugere-se que o método representa uma ferramenta importante para melhorar a força muscular respiratória dessa população.


Objective: To analyze the effects of the Pilates method on respiratory muscle function in children with asthma symptoms. Methods: in this clinical study, a sample of school-age children (9 to 12 years old) of both sexes was included. Initially, the children answered the questionnaire International Study of Asthma and Allergies in Childhood (ISAAC). Thus, those who scored 5 or more were included in the study. Subsequent to this initial screening, the children performed an evaluation of respiratory muscle strength through the digital manovacuometer in order to measure the maximum respiratory pressures (MIP and MEP). An anthropometric assessment was also performed to verify body mass and height. The children participated in an exercise program based on the Pilates method, being performed twice a week, lasting about 50 minutes each session, for 8 months, totaling 32 weeks. Results: regarding the pressures, both inspiratory and expiratory pressure increased at the end of the intervention. Conclusion: the present study found significant contributions of the Pilates method in the inspiratory muscle strength of children with asthma symptoms. Thus, it is suggested that the method represents an important tool to improve the muscular strength of these children.


Subject(s)
Humans , Male , Female , Child , Asthma , Child , Physical Therapy Modalities , Exercise Movement Techniques , Muscle Strength , Lung Diseases , Epidemiology, Descriptive , Evaluation Studies as Topic , Clinical Study
2.
J. Health Biol. Sci. (Online) ; 9(1): 1-7, 2021. tab
Article in English | LILACS | ID: biblio-1362963

ABSTRACT

Objective: When provisional acrylic crowns are used for a long time, they become more susceptible to marginal leakage by cariogenic bacteria. The objectives of this pilot clinical study were to compare cement based on zinc oxide-eugenol and calcium hydroxide by contamination with Streptococcus mutans, and calculate the sample size for the continuation of this study. Methods: Individuals receiving provisional crowns and following inclusion/exclusion criteria, were randomly distributed into 2 groups: zinc oxide-eugenol (n=8); calcium hydroxide (n=9). The temporary crowns were made by a blind researcher and cemented by another. Patients were also blinded by the cement used inside their crowns. After 2 months, a cement sample from the crowns' peripheral inner face was collected, placed in a tube containing 1 mL of sterile saline, serially diluted, plated on Mitis Salivarius Bacitracin agar, and incubated for 48 hours. Colony-forming units (CFU/mL) were counted. A statistical power analysis was performed to calculate sample size (1-ß=80%) and the Mann Whitney test to compare both cements (α=0.05). Results: Both cements were contaminated with S. mutans, with an average of 166.6 x 102 CFU/mL for calcium hydroxide and 435.3 x 102 CFU/mL for zinc oxide-eugenol, with no significant difference (p=0.311). The sample size calculated for this study was 36 per group. Conclusion: This pilot study suggests that there is important contamination inside provisional crowns used for two months, independent of the cement. The continuation of this study is needed, with a bigger sample size, to enable a comparison between the cements.


Objetivo: Quando coroas dentais provisórias são utilizadas por um longo período, elas se tornam susceptíveis à infiltração marginal por bactérias cariogênicas. O objetivo deste estudo clínico piloto foi comparar os cimentos a base de óxido de zinco e eugenol e hidróxido de cálcio pela contaminação com Streptococcus mutans e calcular o tamanho amostral para continuação deste estudo. Métodos: Indivíduos recebendo coroas provisórias e seguindo critérios de inclusão/exclusão, foram distribuídos aleatoriamente em dois grupos: óxido de zinco e eugenol (n=8); hidróxido de cálcio (n=9). As coroas provisórias foram feitas por um pesquisador cego e cimentadas por outro. Os pacientes também foram cegos quanto ao cimento utilizado dentro de suas coroas. Depois de 2 meses, amostras de cimentos foram coletadas da face interna periférica das coroas, colocadas em um tubo contendo 1 mL de solução salina estéril, diluídas de forma seriada, plaqueadas em ágar Mitis Salivarius Bacitracina e incubadas por 48 horas. Unidades formadoras de colônias (UFC/mL) foram contadas. Um teste de poder estatístico foi realizado para calcular o tamanho amostral (1-ß=80%) e o teste de Mann Whitney para comparar os dois cimentos (α=0.05). Resultados: Os dois cimentos foram contaminados com S. mutans, com uma média de 166.6 x 102 UFC/mL para o hidróxido de cálcio e 435.3 x 102 UFC/mL para o óxido de zinco e eugenol, com nenhuma diferença significativa (p=0.311). O cálculo amostral para este estudo foi 36 indivíduos por grupo. Conclusão: Este estudo piloto sugere que existe importante contaminação dentro de coroas provisórias utilizadas por 2 meses, independente do cimento. A continuação deste estudo é necessária, com maior tamanho amostral, para possibilitar a comparação entre os cimentos.


Subject(s)
Streptococcus mutans , Dental Leakage , Zinc Oxide-Eugenol Cement , Calcium Hydroxide , Eugenol , Dental Prosthesis , Tooth Crown , Crowns , Dental Cements , Denture, Partial, Fixed , Clinical Study
3.
Rev. bras. cir. plást ; 35(2): 243-248, apr.-jun. 2020. ilus
Article in English, Portuguese | LILACS | ID: biblio-1103839

ABSTRACT

A pele de tilápia possui microbiota não infecciosa e estrutura morfológica semelhante à pele humana. Estudos clínicos fase II, ainda não publicados, mostraram resultados promissores na sua utilização para tratamento de queimaduras. Nos protocolos destes estudos, pacientes com lesões em áreas de dobras de pele, como genitais e região inguinal, foram excluídos, pois achava-se que o biomaterial não aderiria apropriadamente, resultando em um grau de cicatrização inferior. Relato de caso de paciente do sexo feminino, 18 anos, sem comorbidades, com queimaduras de segundo grau profundo em abdômen, região inguinal, parte da genitália e metade superior de ambas as coxas, envolvendo 13,5% da área total da superfície corporal. A pele de tilápia foi aplicada nas lesões levando a uma reepitelização completa com 16 dias de tratamento. Não foram observados efeitos colaterais. A pele de tilápia traz, portanto, a promessa de um produto inovador, de fácil aplicação e alta disponibilidade, que pode se tornar a primeira pele animal nacionalmente estudada e registrada pela Agência Nacional de Vigilância Sanitária, para uso no tratamento de queimaduras. Este relato de caso contribui para reduzir as limitações em relação às áreas anatômicas apropriadas para a aplicação da pele de tilápia, uma vez que, mesmo com a necessidade de reposição de pele, foram obtidos bons resultados com aplicação na genitália e região inguinal.


Tilapia skin has a non-infectious microbiota and a morphological structure similar to human skin. Phase II clinical studies, not yet published, have shown promising results in their use for the treatment of burns. In the protocols of these studies, patients with lesions in areas of skin folds, such as genitals and inguinal regions, were excluded, as it was thought that the biomaterial would not adhere properly, resulting in a lower degree of healing. Case report of a female patient, 18 years old, without comorbidities, with deep second-degree burns in the abdomen, inguinal region, part of the genitalia and upper half of both thighs, involving 13.5% of the total body surface area. Tilapia skin was applied to the lesions leading to a complete re-epithelialization with 16 days of treatment. No side effects were observed. Tilapia skin, therefore, brings the promise of an innovative product, easy to apply, and highly available, which can become the first animal skin nationally studied and registered by the Agência Nacional de Vigilância Sanitária, for use in the treatment of burns. This case report contributes to reduce the limitations concerning the anatomical areas appropriate for the application of tilapia skin, since, even with the need for skin replacement, good results were obtained with application to the genitalia and inguinal region.


Subject(s)
Humans , Female , Adolescent , History, 21st Century , Therapeutics , Transplantation, Autologous , Biological Dressings , Burns , Case Reports , Therapeutic Approaches , Tilapia , Cichlids , Abdomen , Clinical Study , Genitalia , Hip , Therapeutics/methods , Transplantation, Autologous/methods , Transplantation, Autologous/rehabilitation , Biological Dressings/standards , Burns/therapy , Therapeutic Approaches/adverse effects , Therapeutic Approaches/standards , Tilapia/anatomy & histology , Cichlids/anatomy & histology , Genitalia/anatomy & histology , Abdomen/anatomy & histology , Hip/anatomy & histology
5.
Article in French | AIM, AIM | ID: biblio-1264301

ABSTRACT

Au Mali, le fonctionnement des centres de santé communautaire (CSCOM) est assuré par l'association de santé communautaire (ASACO).L'objectif de l'étude était d'évaluer l'ASACO de Konobougou sur le principe de gestion du CSCOM universitaire, afin d'améliorer les connaissances,aptitudes et pratiques sur la gestion communautaire.Méthodologie : Il s'agissait d'une étude de rechercheaction participative au centre de santé communautaire et universitaire de Konobougou dans la Région de Ségou en 2017 allant de juillet à octobre. Ont participé à cette étude 219 personnes réparties comme suit :200 usagers du centre de santé, 5 agents de santé, 11 membres de l'ASACO et 3 élus communaux.Résultat : Les organes de gestion de l'ASACOexistaient et fonctionnaient. Par contre le comité de surveillance n'était pas fonctionnel, il l'est devenu après le plan d'action. La connaissance de la population sur l'existence de la carte de membre était 32% à l'évaluation initiale contre 82% après le plan d'actions à l'évaluation secondaire. Les membres de l'ASACOqui ne connaissaient pas l'organe de contrôle interne et externe étaient respectivement 37,5% et 25% avant le plan d'action contre 0% à l'évaluation finale.Conclusion : L'ASACO possède des outils sur le principe de gestion des CSCOM. La formation continue permettrait de renforcer sa capacité sur le bon fonctionnement des CSCOM


Subject(s)
Clinical Study , Combined Modality Therapy , Mali
6.
Pan Afr. med. j ; 35(2)2020.
Article in French | AIM, AIM | ID: biblio-1268650

ABSTRACT

Introduction: the global spread of COVID-19 remains unabated in the past few months with a rise in the number of available literature on the novel virus. There are very few paediatric studies and are mainly from developed countries with a paucity of information on the clinical manifestation of COVID-19 disease in African children, including Nigeria. Methods: we described the clinical presentation, laboratory findings, treatment and outcome in a group of five Nigerian children managed at a COVID-19 isolation and treatment centre in Nigeria. Results: we managed a total of five children with an age range of 3 months to 8 years in the last four weeks (16th April to 15th May 2020). Three of the five children were males. All the children had close contact with family members that tested positive for COVID-19. Out of the five children, one had moderate disease, three had mild symptomatic disease, and one was asymptomatic. Two out of the five children had lymphocytosis. Out of the four children who had chest radiograph, two had features of pneumonia. Conclusion: COVID-19 is not uncommon in Nigerian children, and all had a confirmed family member with COVID-19. Besides, contrary to leucopaenia with lymphopaenia observed in the adult's population, we found lymphocytosis in this cohort and about 50.0% had pneumonic changes on chest radiograph


Subject(s)
COVID-19 , Child Health , Clinical Laboratory Services , Clinical Study , Laboratories , Nigeria
7.
Article in English | WPRIM | ID: wpr-811205

ABSTRACT

BACKGROUND: This study evaluated the efficacy of three intraoral topical anesthetics in reducing the injection needle prick pain from local anesthetic among children aged 7–11 years old.METHODS: It is a prospective, Interventional, parallel design, single-blind, randomized clinical trial in which subjects (n=90) aged 7–11 years were included in the study based on an inclusion criteria. Subjects were divided into three groups based on computer-generated randomization with an allocation ratio of 1:1:1. Groups A, B, and C received benzocaine 20% jelly (Mucopain gel, ICPA health products Ltd, Ankleshwar, India), cetacaine anesthetic liquid (Cetylite Industries, Inc, Pennsauken, NJ), and EMLA cream (2% AstraZeneca UK Ltd, Luton, UK), respectively, according to manufacturer's instructions, for 1 minute prior to local anesthetic injection. After application of topical anesthetic agent, for all the groups, baseline pre-operative (prior to topical anesthetic administration) and post-operative scores (after local anesthetic administration) of pulse rate was recorded using Pulse oximeter (Gibson, Fingertip Pulse Oximeter, MD300C29, Beijing Choice Electronic). Peri-operative (i.e., during the administration of local anesthesia) scores were recorded using Face, Legs, Activity, Cry, Consolability (FLACC) Scale, Modified Children hospital of Eastern Ontario Pain Scale (CPS) behavior rating scale, and Faces Pain Scale (FPS-R) – Revised (For self-reported pain). Direct self-reported and physiological measures were ascertained using FPS-R – Revised and Pulse oximeter, respectively, whereas CPS and FLACC scales assessed behavioral measures. To test the mean difference between the three groups, a one way ANOVA with post hoc tests was used. For statistical significance, a two-tailed probability value of P < 0.05 was considered as significant.RESULTS: The Cetacaine group had significantly lower pain scores for self-report (P < 0.001), behavioral, and physiological measures (P < 0.001) than the other two groups. However, there was no significant difference between the Benzocaine group and EMLA group during palatal injection prick.CONCLUSION: Cetacaine can be considered as an effective topical anesthetic agent compared to benzocaine 20% jelly (Mucopain gel) and EMLA cream.


Subject(s)
Anesthetics , Behavior Rating Scale , Beijing , Benzocaine , Child , Clinical Study , Heart Rate , Humans , Leg , Needles , Ontario , Palate , Prospective Studies , Random Allocation , Weights and Measures
8.
Article in English | WPRIM | ID: wpr-811127

ABSTRACT

BACKGROUND: We hypothesized that volar locking pate fixation using a minimum number of screws—four in the distal row and two in the shaft of the plate—will provide sufficient stability for unstable extra-articular fractures of the distal radius. We aimed to compare the biomechanical properties of different numbers and locations of screws in volar locking plate fixation and describe the clinical and radiological outcome of plate fixation using a minimum number of screws for distal radius fractures.METHODS: We divided 48 artificial radius fracture bones into four groups (group A–D) based on the number and location of screws used for fixation with volar locking plates. The artificial bone models were subjected to axial compression and volar bending load with a force of 250 N and 80 N, respectively, for 1,000 cycles at a frequency of 1 Hz. We also retrospectively reviewed 42 patients with unstable, extra-articular, distal radius fractures who were treated with volar locking plate fixation using a minimum number of screws.RESULTS: Group A (seven distal screws and three proximal screws) had the highest mean stiffness: 303.7 N/mm under axial compression and 61.1 N/mm under volar bending. Compared with group A, group D (four screws in the distal part and two screws in the shaft) showed significantly lower stiffness; therefore, group D was considered inferior in terms of stability. However, in the fatigue test, neither deformation of the metal plate nor detachment or breakage of the metal screws was observed in all groups. In the clinical study, all fractures united without displacement and satisfactory clinical outcome was obtained.CONCLUSIONS: In the dorsally comminuted, extra-articular, nonosteoporotic distal radius fractures, the minimum number of screws—four in the distal row and two in the shaft—in volar locking plate fixation can provide sufficient stability. Further biomechanical studies involving osteoporotic bone will be necessary to confirm the results because volar plate fixation is most commonly used in patients with osteoporosis.


Subject(s)
Bone Screws , Clinical Study , Fatigue , Humans , Osteoporosis , Palmar Plate , Radius Fractures , Radius , Retrospective Studies
9.
Asia Pacific Allergy ; (4): 9-2020.
Article in English | WPRIM | ID: wpr-785456

ABSTRACT

BACKGROUND: Recently, the prevalence of food allergies during childhood is increasing, with fruits being common allergens. However, data on allergens that cause fruit and vegetable allergies and pollen-food allergy syndrome (PFAS) in childhood are relatively few. This study aimed to examine the allergens in fruit and vegetable allergies in pediatric patients and to determine the association between fruit and vegetable allergies and PFAS.OBJECTIVE: This study aimed to examine the current status of fruit and vegetable allergies in Japanese children.METHODS: This was a multicenter case series observational study. The participants included children aged <15 years who developed allergic symptoms after eating fruits and vegetables and subsequently received treatment in the Pediatric Department of 6 hospitals in the Osaka Prefecture in Japan during the study period from August 2016 to July 2017. Participants' information was obtained using a questionnaire, and data were obtained by performing several types of allergy tests using blood samples.RESULTS: A total of 97 children (median age, 9 years; 56 males) were included in the study. Apple was the most common allergen, followed by peach, kiwi, cantaloupe, and watermelon. A total of 74 participants (76%) exhibited allergic symptoms due to PFAS; moreover, pathogenesis-related protein-10 (PR-10) was the most common allergen superfamily. On the contrary, in the group where neither PR-10 nor profilin was sensitized, kiwi and banana were the most common allergens, and the age of onset was lower than that in the PFAS group. Specific antibody titer was significantly associated with Birch for Bet v1 and latex for Bet v2 (r = 0.99 and r = 0.89).CONCLUSION: When we examine patients with fruit and vegetable allergies, we should first consider PFAS even in childhood specifically for children greater than 4 years old.


Subject(s)
Age of Onset , Allergens , Asian Continental Ancestry Group , Betula , Child , Citrullus , Clinical Study , Cucumis melo , Eating , Food Hypersensitivity , Fruit , Humans , Hypersensitivity , Japan , Latex , Musa , Observational Study , Prevalence , Profilins , Prunus persica , Rhinitis , Rhinitis, Allergic, Seasonal , Vegetables
10.
Int. arch. otorhinolaryngol. (Impr.) ; 23(3): 276-280, July-Sept. 2019. tab, graf
Article in English | LILACS | ID: biblio-1040023

ABSTRACT

Abstract Introduction Even people with normal hearing may have difficulties locating a sound source in unfavorable sound environments where competitive noise is intense. Objective To develop, describe, validate and establish the normality curve of the sound localization test. Method The sample consisted of 100 healthy subjects with normal hearing, > 18 years old,who agreed to participate in the study. The sound localization testwas applied after the subjects underwent a tonal audiometry exam. For this purpose, a calibrated free field test environment was set up. Then, 30 randompure tones were presented in 2 speakers placed at 45° (on the right and on the left sides of the subject), and the noise was presented froma 3rd speaker, placed at 180°. The noise was presented in 3 hearing situations: optimal listening condition (no noise), noise in relation to 0 dB, and noise in relation to - 10 dB. The subject was asked to point out the side where the pure tone was being perceived, even in the presence of noise. Results All of the 100 participants performed the test in an average time of 99 seconds. The average score was 21, the medium score was 23, and the standard deviation was 3.05. Conclusion The sound localization test proved to be easy to set-up and to apply. The results obtained in the validation of the test suggest that individuals with normal hearing should locate 70% of the presented stimuli. The test can constitute an important instrument in the measurement of noise interference in the ability to locate the sound.


Subject(s)
Humans , Male , Female , Adult , Sound Localization/physiology , Hearing/physiology , Noise , Auditory Threshold/physiology , Reproducibility of Results , Clinical Study , Hearing Tests
11.
Rev. odontol. UNESP (Online) ; 48: e20190005, 2019. tab
Article in English | LILACS, BBO | ID: biblio-1043177

ABSTRACT

Abstract Introduction Actinic cheilitis is a inflammatory condition affecting mainly the lower lip and it is caused by chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. Objective Identifying clinical and histopathologic characteristics in 40 cases histopathologically diagnosed as actinic cheilitis. In addition, to investigate possible associations between these aspects. Method Defined as an observational, transversal, retrospective and descriptive study, it registered data regarding age, gender, occupation, symptomatology, records of sun exposure, frequency of sunblock use, tabagism, skin color, clinical aspect and histopathological classification. The data was submitted to the chi square test of Pearson (p<0.05). Result There was a predominance of male gender, leucodermia, and ages ranging between 50 and 60 years. The most common occupation was farming. From our sample, 85% had history of chronic sun exposure, in which 50% reported the use of some type of sunblock and only 25% were smokers. The main clinical condition was non-ulcerated leukoplakia and in the histopathological study, the hyperkeratosis were more common. A correlation between the degree of tissue alteration verified in the histopathological diagnosis and the studied clinical variables was not established (p=0.112). Conclusion The clinical aspect of the wound can conceal tissue alterations in different stages, emphasizing the importance of a premature diagnosis.


Resumo Introdução A queilite actínica e uma condição de natureza inflamatória que acomete o lábio inferior, e é causada pela exposição prolongada e crônica dos lábios à radiação ultravioleta proveniente dos raios solares. Objetivo Identificar as características clínicas e histopatológicas em uma série de 40 casos diagnosticados histopatologicamente como queilite actínica. Além disso, investigar possíveis associações entre estes aspectos. Método Caracterizado como um estudo observacional, transversal, retrospectivo e descritivo. Foram registrados dados a respeito da idade, gênero, ocupação, sintomatologia, histórico de exposição ao sol, uso de proteção solar, tabagismo, cor da pele, aspecto clínico e classificação histopatológica. Os dados foram submetidos ao teste de Qui-Quadrado de Pearson (p<0,05). Resultado Houve uma prevalência do gênero masculino, leucodermas, com faixa etária entre 50 e 60 anos e a ocupação mais presente foi a de agricultor. Da amostra, 85% apresentou histórico de exposição crônica ao sol, onde 50% relatou uso de algum tipo de proteção solar e apenas 25% era tabagista. A principal apresentação clínica foi leucoplasia não ulcerada, e no estudo histopatológico as hiperceratoses foram as mais presentes. Não foi possível correlacionar o grau de alteração tecidual verificada no diagnóstico histopatológico com as variáveis clínicas estudadas (p=0,112). Conclusão Não foi possível correlacionar o grau de alteração tecidual verificada no diagnóstico histopatológico com os aspectos clínicos observados. O aspecto clínico da lesão pode mascarar alterações teciduais em diversos estágios, o que enaltece a importância do diagnóstico precoce.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Precancerous Conditions/pathology , Cheilitis , Clinical Study , Pathology, Clinical , Clinical Diagnosis
12.
Korean Journal of Radiology ; : 1358-1367, 2019.
Article in English | WPRIM | ID: wpr-760303

ABSTRACT

OBJECTIVE: To compare image qualities between vendor-neutral and vendor-specific hybrid iterative reconstruction (IR) techniques for abdominopelvic computed tomography (CT) in young patients. MATERIALS AND METHODS: In phantom study, we used an anthropomorphic pediatric phantom, age-equivalent to 5-year-old, and reconstructed CT data using traditional filtered back projection (FBP), vendor-specific and vendor-neutral IR techniques (ClariCT; ClariPI) in various radiation doses. Noise, low-contrast detectability and subjective spatial resolution were compared between FBP, vendor-specific (i.e., iDose1 to 5; Philips Healthcare), and vendor-neutral (i.e., ClariCT1 to 5) IR techniques in phantom. In 43 patients (median, 14 years; age range 1–19 years), noise, contrast-to-noise ratio (CNR), and qualitative image quality scores of abdominopelvic CT were compared between FBP, iDose level 4 (iDose4), and ClariCT level 2 (ClariCT2), which showed most similar image quality to clinically used vendor-specific IR images (i.e., iDose4) in phantom study. Noise, CNR, and qualitative imaging scores were compared using one-way repeated measure analysis of variance. RESULTS: In phantom study, ClariCT2 showed noise level similar to iDose4 (14.68–7.66 Hounsfield unit [HU] vs. 14.78–6.99 HU at CT dose index volume range of 0.8–3.8 mGy). Subjective low-contrast detectability and spatial resolution were similar between ClariCT2 and iDose4. In clinical study, ClariCT2 was equivalent to iDose4 for noise (14.26–17.33 vs. 16.01–18.90) and CNR (3.55–5.24 vs. 3.20–4.60) (p > 0.05). For qualitative imaging scores, the overall image quality ([reader 1, reader 2]; 2.74 vs. 2.07, 3.02 vs. 2.28) and noise (2.88 vs. 2.23, 2.93 vs. 2.33) of ClariCT2 were superior to those of FBP (p 0.05). CONCLUSION: Vendor-neutral IR technique shows image quality similar to that of clinically used vendor-specific hybrid IR technique for abdominopelvic CT in young patients.


Subject(s)
Abdomen , Child, Preschool , Clinical Study , Humans , Noise
13.
Gut and Liver ; : 642-648, 2019.
Article in English | WPRIM | ID: wpr-763886

ABSTRACT

BACKGROUND/AIMS: Bicarbonate-containing alginate formulations are reported to be effective for controlling reflux symptoms. However, the efficacy of Lamina G alginate without gas production has not been reported. The aim is to evaluate the efficacy of a non-bicarbonate alginate in individuals with reflux symptoms without reflux esophagitis. METHODS: Participants who had experienced heartburn or regurgitation for 7 consecutive days were randomized to one of the following treatment groups: proton pump inhibitors (PPI) plus alginate (combination) or PPI plus placebo (PPI only). In addition, as a reference group, patients received placebo plus alginate (alginate only). The primary endpoint compared the percentage of patients with complete resolution of symptoms for the final 7 days of the treatment. Secondary endpoints compared changes in symptom score, symptom-free days during the treatment period, the Reflux Disease Questionnaire, Patient Assessment of Upper Gastrointestinal Disorders (PAGI)-Quality of Life and PAGI-Symptoms Severity Index scores, the investigator's assessment of symptoms, and incidence of adverse events. RESULTS: Complete resolution of heartburn or regurgitation was not significantly different between the combination and PPI only groups (58.7% vs 57.5%, p=0.903). The secondary endpoints were not significantly different between the two groups. Complete resolution of heartburn or regurgitation, did not differ between the alginate only reference group and the PPI only group (75.0% vs 57.5%, p=0.146). CONCLUSIONS: The addition of non-bicarbonate alginate to PPI was no more effective than PPI alone in controlling reflux symptoms.


Subject(s)
Alginates , Clinical Study , Esophagitis, Peptic , Gastroesophageal Reflux , Heartburn , Humans , Incidence , Proton Pump Inhibitors , Treatment Outcome
14.
Article in Korean | WPRIM | ID: wpr-760114

ABSTRACT

BACKGROUND AND OBJECTIVES: Acute epiglottitis is a life-threatening condition that can result in airway obstruction. The present study reports clinical features, management and patient outcomes in an acute epiglottitis. SUBJECTS AND METHOD: Included in our retrospective study were 315 patients who were admitted with the diagnosis of acute epiglottitis between January 2006 and July to the department Otolaryngology-Head and Neck surgery, Hallym University Sacred Heart Hospital 2018. The diagnosis of acute epiglottitis was established by confirmation of inflamed epiglottis using laryngoscope or computed tomography. RESULTS: Among 315 patients, 89 cases (28%) and 83 cases (26%) were found in the fifth and fourth decades, respectively. The mean age of patients was 45.0±13.94 years. The male to female ratio was 1.33:1. A total of 75 patients (23.8%) had co-morbidities, with hypertension (13.6%) being the most common. Fever was relatively uncommon, whereas most patients complained of sore throat. Ceftriaxone was the most common empirical antibiotic regimen prescribed and the use of steroids did not affect the length of hospital stay. Nine patients required airway intervention, including eight who underwent endotracheal intubation and one emergency tracheostomy. In patients who need airway intervention, systolic blood pressure, body temperature, respiratory rate, heart rate, white blood cells and the proportion of dyspnea were significantly higher in comparison to the patients without airway intervention. CONCLUSION: Although acute epiglottitis often has nonspecific symptoms, it may lead to sudden dyspnea and unstable vital signs, so an in-depth understanding of this disease is needed.


Subject(s)
Airway Obstruction , Anti-Bacterial Agents , Blood Pressure , Body Temperature , Ceftriaxone , Clinical Study , Diagnosis , Dyspnea , Emergencies , Epiglottis , Epiglottitis , Female , Fever , Heart , Heart Rate , Humans , Hypertension , Intubation, Intratracheal , Korea , Laryngoscopes , Length of Stay , Leukocytes , Male , Methods , Neck , Pharyngitis , Respiratory Rate , Retrospective Studies , Steroids , Tracheostomy , Vital Signs
15.
Article in Korean | WPRIM | ID: wpr-759771

ABSTRACT

BACKGROUND: Acne is a common inflammatory skin disease that involves the seborrheic area, developing not only in adolescence but also in adulthood. Abnormal epidermal barrier function in acne is reported and suspected as a risk factor that leads to sensitive skin through a few experimental studies. Impaired skin barrier function against environmental factors and irritants may play a role in increasing sensitivity of the skin in patients with acne. OBJECTIVE: This study aimed to investigate the clinical characteristics of patients with acne and analyze the association between acne and sensitive skin. METHODS: Acne severity and history of treatments were recorded and subjective symptoms of sensitive skin with aggravating factors were analyzed through a questionnaire. Acne severity was determined using the Investigator's Global Assessment scale of acne severity and Global Acne Grading System. The score and severity of sensitive skin were determined using the Baumann skin-type test. RESULTS: Of 100 patients with acne, 76% were actually confirmed to have sensitive skin. However, there was no significant association between acne severity and severity of sensitive skin (p=0.805). The most common aggravating factor of sensitive skin was washing the face (60%), followed by cosmetics use (56%) and hot weather (55%). The most common symptom of sensitive skin was itching (55%), which was proven as the only factor associated with severity of sensitive skin (p=0.016). CONCLUSION: Cosmetics use on the face is a noticeable important aggravating factor of sensitive skin, which can provoke itching, which is proven as the only symptom significantly related with severity of sensitive skin. Therefore, in the treatment of acne with sensitive skin, proper use of moisturizers and careful washing are required, and it is important to avoid hot weather and excessive sun exposure and carefully choose cosmetics.


Subject(s)
Acne Vulgaris , Adolescent , Clinical Study , Humans , Irritants , Pruritus , Risk Factors , Skin Diseases , Skin , Solar System , Weather
16.
Article in English | WPRIM | ID: wpr-759732

ABSTRACT

BACKGROUND: The development of a safe and convenient agent that can promote hair growth in patients with androgenetic alopecia remains challenging. OBJECTIVE: This study was designed to investigate the efficacy of a newly developed hair tonic containing a human umbilical cord blood mesenchymal stem cell (hUCB-MSC)-derived conditioned medium in promoting hair growth. METHODS: This double-blind, placebo-controlled clinical study investigated the efficacy of a hair tonic containing an hUCB-MSC-derived conditioned medium in 30 patients with patterned hair loss. Treatment efficacy was determined using phototrichograms to evaluate the density, diameter, and hair growth rate at baseline levels and after 4, 8, and 16 weeks of treatment. RESULTS: The hair density in the group treated with the hair tonic significantly increased from 125.2 to 134.6 hairs/cm2 (p<0.05). In this same group, the thickness of hair also increased from 0.083 to 0.110 mm (p<0.05). Additionally, the hair growth rate increased from 0.285 to 0.338 mm/day (p<0.05). No severe adverse reactions were reported. CONCLUSION: A hair tonic containing an hUCB-MSC-derived conditioned medium could be a new effective alternative to treat patients with androgenetic alopecia.


Subject(s)
Alopecia , Clinical Study , Culture Media, Conditioned , Fetal Blood , Hair Preparations , Hair , Humans , Mesenchymal Stem Cells , Treatment Outcome , Umbilical Cord
17.
Article in Korean | WPRIM | ID: wpr-759696

ABSTRACT

BACKGROUND: Rosacea is a relatively common inflammatory skin disease characterized by central facial erythema that persists for several months or longer. Experimental studies have demonstrated that rosacea compromises the epidermal barrier protection against allergens and irritants, rendering rosacea patients susceptible to contact hypersensitivity and skin irritation. OBJECTIVE: This study aimed to investigate allergic and irritant reactions to topical agents and cosmetics in rosacea patients using patch tests. METHODS: Rosacea signs and subtypes of 40 patients were recorded and subjective symptoms and clinical experiences related to topical agents and cosmetics were assessed using a questionnaire. Patch tests were performed in these patients using the Korean Standard Series (Chemotechnique Diagnostics, Sweden), the TRUE test® (Mekos Laboratories ApS, Denmark), and 26 selected fragrance and 31 cosmetic antigens (TROLAB, Germany). RESULTS: Of 40 patch-tested patients, 26 (65%) showed at least 1 positive reaction and 13 (32.5%) showed 2 or more positive reactions. The most common allergens were nickel (II) sulfate (50%), cobalt chloride (10%), epoxy resin (7.7%), and thimerosal (7.5%). Thirteen patients (32.5%) experienced irritant patch test reactions. There were no significant differences in allergic or irritant positive reactions between mild, moderate, and severe cases of rosacea or between rosacea subtypes. Irritant reactions were more common in fair-skinned participants. CONCLUSION: Different topical medications are used in the treatment of rosacea patients. Exacerbation of rosacea may be caused by a hypersensitivity reaction or irritation induced by the topical agent or by cosmetics.


Subject(s)
Allergens , Clinical Study , Cobalt , Dermatitis, Contact , Erythema , Humans , Hypersensitivity , Irritants , Nickel , Patch Tests , Rosacea , Skin , Skin Diseases , Thimerosal
18.
Article in English | WPRIM | ID: wpr-759563

ABSTRACT

BACKGROUND: This study aimed to determine the optimal location of local anesthetic injection in the interspace between the popliteal artery and posterior capsule of the knee (iPACK), using the anatomical pattern of the articular branch of tibial nerve (ABTN). We hypothesized that injection at the level of ABTN forming a popliteal plexus would mainly spread throughout the popliteal fossa without contacting the tibial or peroneal nerves. METHODS: The anatomical study included 30 soft cadavers. Ultrasound-guided dye injection was performed in legs of 10 cadavers after identifying the position of the ABTN and surrounding structures, followed by dissection to assess its spread. Clinical study was conducted in 15 patients undergoing total knee arthroplasty (TKA) with ultrasound-guided injection in the iPACK. All patients also received continuous adductor canal block. Sensorimotor function of the tibial and common peroneal nerves was determined. RESULTS: In the distal portion of the popliteal fossa, the tibial nerve and popliteal vessels ran superficially and closely together. The trajectory of ABTN ran lateral to the popliteal vasculature, forming a plexus towards the posterior capsule of the knee below the medial side of the upper edge of lateral femoral condyle. In cadavers, the ABTN and surrounding area of the popliteal plexus were stained with dye after injection. In the clinical study, no patients experienced complete motor or sensory blocks. CONCLUSIONS: We described a modified iPACK technique injection at the level of the ABTN forming the popliteal plexus, and it may constitute an optional anesthetic regimen to promote early ambulation following TKA.


Subject(s)
Arthroplasty, Replacement, Knee , Cadaver , Clinical Study , Early Ambulation , Humans , Knee , Leg , Pain, Postoperative , Peroneal Nerve , Popliteal Artery , Tibial Nerve
19.
Article in Korean | WPRIM | ID: wpr-765637

ABSTRACT

STUDY DESIGN: Retrospective study. OBJECTIVES: The purpose of this study was to analyze and report the results of caudal epidural injections using a catheter in patients in whom conventional epidural block had failed. SUMMARY OF LITERATURE REVIEW: Epidural nerve block is often used to treat chronic back pain and radicular pain in degenerative lumbar disease, and percutaneous epidural neuroplasty or surgery may be an alternative if it fails. MATERIALS AND METHODS: In total, 146 patients who were treated with caudal epidural block using a catheter were recruited for this study from January 1, 2015 to June 30, 2019. Forty-five patients who had not undergone any epidural block in the past were excluded from the study. Among patients who did not have a fracture and were followed up for at least 1 month, the medical records of 61 patients with degenerative disc herniation, spondylosis, and stenosis were reviewed retrospectively. Visual analogue scale (VAS) scores were evaluated before and after the procedure. RESULTS: Of the 61 patients who had undergone epidural block through a transforaminal caudal approach with no pain control effect, there were 18 males and 43 females. Their mean age was 66.3 years and the average follow-up period was 2.64 months. There were 46 cases of spinal stenosis, 33 cases of spondylosis, 2 cases of spondylolisthesis, 9 cases of disc herniation and 1 case of ankylosing spondylitis. The mean number of epidural blocks was 5.85 (times) before the procedure. The mean initial VAS score was 5.34 and the final follow-up VAS score was 2.70. There was a significant difference between before and after the procedure (p<0.05). The mean duration of effect after the procedure was 1.84 months and the mean number of procedures was 2.30. After the procedure, there were 4 cases of surgical treatment, 2 cases of neuroplasty, and 3 cases of epidural block using other methods over more than 1 year of follow-up. CONCLUSIONS: The result of this clinical study suggests that caudal epidural injections using a catheter may be effective for patients with low back pain who have not responded to previous epidural blocks before surgical treatment.


Subject(s)
Back Pain , Catheters , Clinical Study , Constriction, Pathologic , Female , Follow-Up Studies , Humans , Injections, Epidural , Low Back Pain , Male , Medical Records , Nerve Block , Retrospective Studies , Spinal Stenosis , Spondylitis, Ankylosing , Spondylolisthesis , Spondylosis
20.
Article in English | WPRIM | ID: wpr-765358

ABSTRACT

OBJECTIVE: The functional information of ¹¹C-methionine positron emission tomography (MET-PET) images can be applied for Gamma knife radiosurgery (GKR) and its image quality may affect defining the tumor. This study conducted the phantom-based evaluation for geometric accuracy and functional characteristic of diagnostic MET-PET image co-registered with stereotactic image in Leksell GammaPlan® (LGP) and also investigated clinical application of these images in metastatic brain tumors. METHODS: Two types of cylindrical acrylic phantoms fabricated in-house were used for this study : the phantom with an array-shaped axial rod insert and the phantom with different sized tube indicators. The phantoms were mounted on the stereotactic frame and scanned using computed tomography (CT), magnetic resonance imaging (MRI), and PET system. Three-dimensional coordinate values on co-registered MET-PET images were compared with those on stereotactic CT image in LGP. MET uptake values of different sized indicators inside phantom were evaluated. We also evaluated the CT and MRI co-registered stereotactic MET-PET images with MR-enhancing volume and PET-metabolic tumor volume (MTV) in 14 metastatic brain tumors. RESULTS: Imaging distortion of MET-PET was maintained stable at less than approximately 3% on mean value. There was no statistical difference in the geometric accuracy according to co-registered reference stereotactic images. In functional characteristic study for MET-PET image, the indicator on the lateral side of the phantom exhibited higher uptake than that on the medial side. This effect decreased as the size of the object increased. In 14 metastatic tumors, the median matching percentage between MR-enhancing volume and PET-MTV was 36.8% on PET/MR fusion images and 39.9% on PET/CT fusion images. CONCLUSION: The geometric accuracy of the diagnostic MET-PET co-registered with stereotactic MR in LGP is acceptable on phantom-based study. However, the MET-PET images could the limitations in providing exact stereotactic information in clinical study.


Subject(s)
Brain Neoplasms , Clinical Study , Electrons , Magnetic Resonance Imaging , Multimodal Imaging , Phantoms, Imaging , Positron Emission Tomography Computed Tomography , Positron-Emission Tomography , Radiosurgery , Tumor Burden
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