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1.
Rev. bras. cir. cardiovasc ; 36(5): 629-638, Sept.-Oct. 2021. tab, graf
Article in English | LILACS | ID: biblio-1351655

ABSTRACT

Abstract Introduction: This study aims to evaluate late postoperative neurophysiological outcomes in patients after coronary artery bypass grafting (CABG). Methods: Forty-five male patients with stable coronary artery disease aged 45-69 years underwent extended neuropsychological assessment using the software Status PF and electroencephalographical examination 3-5 days before CABG and 5-7 years after CABG. Postoperative decline in cognitive functions was determined by a 20% decrease in the cognitive indicator compared to that at baseline on 20% of the tests included in the Status PF battery. Statistical analysis was performed using the software STATISTICA 10.0. Multiple regression was used to identify demographic, clinical, and electroencephalographical variables associated with adverse cognitive outcomes. Results: Cognitive decline was observed in 54% of the patients in the long-term postoperative period. Five to seven years after CABG, all patients have shown an increase in the theta rhythm power compared to the preoperative values, which is most pronounced in the frontal and temporal areas of the right hemisphere (P=0.04), along with a decrease in the alpha rhythm in the posterior areas of the cortex (P=0.005). Multiple regression has reported that the main predictors of cognitive impairment are slower mean alpha frequency, decreased theta-2 rhythm with eyes closed in the right temporal area, and increased theta-2 rhythm with eyes open in the left temporal area (F(5.39)=8.81; P<0.00007; adjusted R-squared=0.57). Conclusion: Our findings indicate that 54% of the patients suffer from postoperative cognitive decline associated with increased theta and decreased alpha rhythms 5-7 years after CABG.


Subject(s)
Coronary Artery Disease/surgery , Cognition Disorders/etiology , Cognitive Dysfunction , Postoperative Complications/etiology , Coronary Artery Bypass , Neuropsychological Tests
3.
Arq. bras. neurocir ; 39(4): 256-260, 15/12/2020.
Article in English | LILACS | ID: biblio-1362318

ABSTRACT

Traumatic brain injury (TBI) is a major public health problem inWestern countries. ATBI brings many negative consequences, including behavioral and cognitive changes, which affect social adjustment and the performance of functional activities. Cognitive evaluation after TBI is a complex issue in what pertains to definition of the most appropriate questionnaires for clinical use in a comprehensive analysis of the condition of the patient. In this paper, we described a critical review of the main cognitive assessment tests currently used in clinical and research settings in patients with TBI.


Subject(s)
Cognition Disorders/etiology , Brain Injuries, Traumatic/complications , Neuropsychological Tests/standards , Psychometrics/methods , Reproducibility of Results , Cognition , Diffuse Axonal Injury/complications , Post-Concussion Syndrome
4.
Int. arch. otorhinolaryngol. (Impr.) ; 24(1): 99-106, Jan.-Mar. 2020. tab
Article in English | LILACS | ID: biblio-1090548

ABSTRACT

Abstract Introduction Peripheral vestibular disorders can lead to cognitive deficits and are more common in elderly patients. Objective To evaluate and correlate cognitive, balance and gait aspects in elderly women with chronic peripheral vestibular dizziness, and to compare them with elderly women without vestibular disorders. Methods Twenty-two women presenting peripheral vestibular dizziness episodes for at least six months participated in the study. The individuals were categorized by dizziness severity level: moderate (n = 11) or severe (n = 11). The control group (n = 11) included women showing no vestibulopathy, light-headedness or dizziness. Cognitive assessments and semi-static and dynamic balance assessments were performed with the Balance Master (Neurocom International, Inc., Clackamas, OR), while the Dizziness Handicap Inventory provided a score for the severity of the symptoms. The groups were submitted to statistics of inference and correlation between cognitive, balance and stability variables. Results The group with severe dizziness showed higher sway speed of the center of pressure in the anteroposterior direction, smaller step length, and slower gait than the control group. Regarding the cognitive variables, the group with severe dizziness symptoms presented significant correlations with stability and gait variables. Conclusion The relationship between cognitive aspects, balance and gait was stronger in women with severe dizziness than in those with no vestibulopathy.


Subject(s)
Humans , Female , Middle Aged , Aged , Vestibular Diseases/complications , Sensation Disorders/etiology , Dizziness/complications , Postural Balance/physiology , Severity of Illness Index , Vestibular Diseases/physiopathology , Vestibular Diseases/rehabilitation , Cognition Disorders/etiology , Dizziness/physiopathology , Gait/physiology
5.
Fisioter. Pesqui. (Online) ; 27(1): 41-47, jan.-mar. 2020. tab
Article in Portuguese | LILACS | ID: biblio-1090407

ABSTRACT

RESUMO As cardiopatias congênitas (CC) estão entre as principais causas de morbimortalidade na primeira infância e os lactentes com essa condição podem apresentar atrasos no desenvolvimento neuropsicomotor (DNPM). O objetivo deste estudo foi avaliar a influência da CC no DNPM de lactentes. Trata-se de um estudo observacional com avaliação do desenvolvimento neuropsicomotor realizada pela Bayley Scales of Infant and Toddler Development (BSID-III). As condições maternas e clínicas dos lactentes foram verificadas no relatório de alta médica e na caderneta de saúde da criança, e a condição socioeconômica das famílias pelo Critério da Classificação Econômica Brasil. Para associar as variáveis clínicas e o DNPM foram utilizados o coeficiente de correlação de Spearman e o teste de razão de verossimilhança. Foram avaliados 18 lactentes, com predomínio do sexo feminino (72,2%). A maioria das mães (47,1%) possuía ensino médio completo ou superior incompleto, com média da idade de 27,2±5,5 anos. Houve correlação das escalas do BSID-III com as variáveis quantitativas analisadas: escala motora com o peso (p=0,02 e r=0,54) e com uso de oxigenoterapia (p=0,009 e r=−0,591); já para as variáveis qualitativas as associações foram entre: escala motora e condição socioeconômica (p=0,015), escala motora e comunicação interatrial - (CIA) (p=0,023) e escala da linguagem e CIA (p=0,038). A CC influenciou o DNPM, principalmente no aspecto motor. Além disso peso, diagnóstico de CIA, uso de oxigenoterapia e condição socioeconômica foram considerados como principais fatores de risco para o atraso no DNPM.


RESUMEN Las cardiopatías congénitas (CC) se encuentran entre las principales causas de morbimortalidad en la primera infancia, y los lactantes con esta afección pueden tener retrasos en el desarrollo neuropsicomotor (DNPM). El presente estudio tuvo el objetivo de evaluar la influencia de las CC en el DNPM de los lactantes. Este es un estudio observacional en el cual se evaluó el desarrollo neuropsicomotor utilizando la Bayley scales of infant and toddler development (BSID-III). Las condiciones maternas y clínicas de los lactantes se obtuvieron en el informe de alta médica y en la libreta de salud del niño, y el estado socioeconómico de las familias en el Criterio de Clasificación Económica de Brasil. Para asociar las variables clínicas y el DNPM, se utilizaron el coeficiente de correlación de Spearman y la prueba de razón de probabilidad. Se evaluaron a 18 lactantes, con un predominio del sexo femenino (72,2%). La mayoría de las madres (47,1%) tenían la secundaria completa o la educación superior incompleta, con una edad promedio de 27,2±5,5 años. Hubo una correlación entre las escalas BSID-III y las variables cuantitativas analizadas: escala motora con el peso (p=0,02 y r=0,54) y con el uso de oxigenoterapia (p=0,009 y r=−0,591); para las variables cualitativas, las asociaciones fueron entre: escala motora y estado socioeconómico (p=0,015), escala motora y comunicación interauricular (CIA) (p=0,023) y escala de lenguaje y CIA (p=0,038). Las CC influyeron en el DNPM, principalmente en el aspecto motor. Además, el peso, el diagnóstico de CIA, el uso de oxigenoterapia y el estado socioeconómico fueron considerados los principales factores de riesgo para el retraso en el DNPM.


ABSTRACT Congenital heart defects (CHD) are among the main causes of morbidity and mortality in infants who has this impairment may present delays in neuropsychomotor development (NPMD). This study assesses the influence of CHD on NPMD of infants. This is an observational study assessing neuropsychomotor development performed by Bayley Scales of Infant and Toddler Development - BSID-III. The Brazilian Economic Classification Criteria was used to verify the socioeconomic status of the families and also the maternal and infants' clinical conditions were verified in the medical discharge report and in the child's health handbook. For the association between the quantitative and qualitative variables with the NPMD, the Spearman's correlation coefficient and the likelihood ratio test were used. A total of 18 infants were assessed, with a predominance of females (72.2%). Most mothers (47.1%) had complete high school or incomplete higher education, with a mean age of 27.2±5.5 years. There was a correlation between the BSID-III scales and the quantitative variables analyzed: motor scale with weight (p=0.02 and r=0.54) and oxygen therapy (p=0.009 and r=−0.591); besides that, the qualitative variables correlation were: motor scale and socioeconomic condition (p=0.015), motor scale and Interatrial Communication - IAC (p=0.023) and language with IAC scales (p=0.038). CHD influences the delay of NPMD, mainly for motor aspect. Furthermore, weight, diagnosis of IAC, use of oxygen therapy and socioeconomic status were considered the main risk factors for the delay in NPMD.


Subject(s)
Humans , Infant , Psychomotor Disorders/etiology , Motor Skills Disorders/etiology , Neurodevelopmental Disorders/etiology , Heart Defects, Congenital/complications , Oxygen Inhalation Therapy/adverse effects , Psychomotor Disorders/diagnosis , Socioeconomic Factors , Child Development/physiology , Cross-Sectional Studies , Cognition Disorders/diagnosis , Cognition Disorders/etiology , Motor Skills Disorders/diagnosis , Neurodevelopmental Disorders/diagnosis , Hospitalization , Language Disorders/diagnosis , Language Disorders/etiology , Length of Stay , Neuropsychological Tests
6.
Rev. bras. cir. cardiovasc ; 34(6): 739-748, Nov.-Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057500

ABSTRACT

Abstract Introduction: The true influence of the low mean arterial pressure (low MAP) during coronary artery bypass grafting (CABG) on the development of postoperative cognitive deficit (POCD) remains controversial. We aimed to perform a meta-analysis and meta-regression to determine the effect of low MAP on POCD, as well as moderator variables between low MAP and POCD. Methods: The Web of Science, PubMed database, Scopus and the Cochrane Library database (up to June 2018) were searched and retrieved articles systematically reviewed. Only randomized controlled trials (RCTs) comparing maintenance of low MAP (<80 mmHg) and high MAP (>80 mmHg) during cardiopulmonary bypass (CPB) were included in our final review. Statistical analysis of the risk ratio (RR) and corresponding 95% confidence interval (CI) was used to report the overall effect. The overall effect and meta-regression analysis were done using Mantel-Haenszel risk ratio (MHRR) and the corresponding 95% confidence interval (CI). Results: A total of 731 patients in three RCTs were included in this study. POCD occurred in 6.4% of all cases. Maintenance of low MAP did not reduce the occurrence of POCD (MHRR 1.012 [95% CI 0.277-3.688]; Z=0.018; P=0.986; I2=66%). Shorter CPB time reduced the occurrence of POCD regardless of group assignment (MH log risk ratio -0.519 [95% CI -0.949 - -0.089]; Z= -2.367; P=0.017). Conclusion: POCD is a common event among CABG patients. The neuroprotective effect of low MAP on POCD was attenuated by the prolonged CPB time.


Subject(s)
Humans , Male , Female , Postoperative Complications/prevention & control , Coronary Artery Bypass/rehabilitation , Cognition Disorders/prevention & control , Hypotension , Postoperative Complications/etiology , Postoperative Period , Coronary Artery Bypass/adverse effects , Risk Factors , Cognition Disorders/etiology , Extracorporeal Circulation , Arterial Pressure , Neuropsychological Tests
7.
Trends psychiatry psychother. (Impr.) ; 41(4): 327-333, Oct.-Dez. 2019. tab, graf
Article in English | LILACS | ID: biblio-1059180

ABSTRACT

Abstract Introduction Cognitive impairment in chronic kidney disease (CKD) is commonly associated with neuropsychiatric disorders. As a complex pathology, at all stages of CKD patients need to have a good understanding of the need for drug and nutritional adherence. Cognitive screening is the starting point for detection of cognitive impairments. Objective To determine the specificity and sensitivity of the Brazilian Portuguese version of the Montreal Cognitive Assessment - Basic (MoCA-B) for identification of cognitive impairment in the CKD population. Methods This was a cross-sectional study with 163 CKD patients undergoing hemodialysis treatment. The Mini-Mental State Examination (MMSE) and MoCA-B were administered. Results The MoCA-B has reliable internal consistency (Cronbach's alpha = 0.74). A cutoff point of ≤ 21 points provides the best sensitivity and specificity for detection of cognitive impairment. The education variable had less impact on the total MoCA-B score than on the total MMSE score. Conclusions The MoCA-B is a suitable screening instrument for evaluating the global cognition of hemodialysis patients. The results can help health professionals to conduct evaluations and plan clinical management.


Resumo Introdução O comprometimento cognitivo na doença renal crônica (DRC) é comumente associado a distúrbios neuropsiquiátricos. Sendo uma patologia complexa, a DRC, em qualquer estágio, requer que o paciente tenha uma boa compreensão da necessidade de adesão ao medicamento e à nutrição. A triagem cognitiva é o ponto de partida para a detecção de deficiências cognitivas. Objetivo Determinar a especificidade e a sensibilidade da versão em português do Brasil do Montreal Cognitive Assessment - Basic (MoCA-B) para identificação de comprometimento cognitivo na população com DRC. Métodos Este foi um estudo transversal com 163 pacientes com DRC em tratamento hemodialítico. Foram aplicados o Mini Exame do Estado Mental (MEEM) e o MoCA-B. Resultados O MoCA-B obteve consistência interna confiável (alfa de Cronbach = 0,74). Um ponto de corte de ≤ 21 pontos fornece a melhor sensibilidade e especificidade para a detecção de comprometimento cognitivo. A variável educação teve menos impacto no escore total do MoCA-B do que no escore total do MEEM. Conclusões O MoCA-B é um instrumento de triagem adequado para avaliar a cognição global de pacientes em hemodiálise. Os resultados podem ajudar os profissionais de saúde a realizar avaliações e planejar o manejo clínico.


Subject(s)
Humans , Male , Female , Adult , Aged , Aged, 80 and over , Young Adult , Cognition Disorders/etiology , Renal Insufficiency, Chronic/complications , Mental Status and Dementia Tests , Brazil , Cross-Sectional Studies , Reproducibility of Results , Sensitivity and Specificity , Cognition Disorders/diagnosis , Renal Insufficiency, Chronic/psychology , Middle Aged
8.
J. pediatr. (Rio J.) ; 95(4): 451-457, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1040345

ABSTRACT

Abstract Objective: To evaluate the cognitive abilities of children and adolescents with sickle cell anemia diagnosed through neonatal screening and to compare them with healthy controls, adjusting the results to their socioeconomic status. Methods: Cognitive assessment was performed with the Wechsler WISC-III scale in 64 children and adolescents with sickle cell anemia and in 64 controls matched by gender and age, without the disease and without neurological impairment; socioeconomic status was measured by the Criterion Brasil. Results: All cognitive scores were lower in the group of patients. The mean overall IQ, Verbal IQ, and Performance IQ were, respectively, 90.95 for the group of patients and 113.97 for the controls (p < 0.001); 91.41 for the group of patients and 112.31 for the controls (p < 0.001); 92.34 for the group of patients and 113.38 for the controls (p < 0.001). Scores for processing speed, distraction resistance, and perceptual organization were also significantly lower in patients. A direct and significant correlation was detected between socioeconomic status and cognitive scores. In the multivariate analysis, for the same socioeconomic status, a child with sickle cell anemia had an average IQ of 21.2 points lower than the mean IQ observed for the controls (p < 0.001), indicating that the disease, adjusted for the socioeconomic effect, is a strong predictor of the overall IQ. Conclusion: The cognitive impairment of children with sickle cell anemia is severe and manifests even when the disease effect is adjusted to the socioeconomic status. In the authors' view, such impairment requires an early preventive approach in order to avoid this cognitive damage.


Resumo Objetivo: Avaliar os sistemas cognitivos de crianças e adolescentes com anemia falciforme provenientes de triagem neonatal e compará-las com controles sadios, ajustando-se os resultados para o nível socioeconômico. Método: A avaliação cognitiva foi feita com a escala de Wechsler WISC-III em 64 crianças e adolescentes com anemia falciforme e em 64 controles pareados por sexo e idade, sem a doença e sem comprometimento neurológico; o nível socioeconômico foi aferido pelo Critério Brasil. Resultados: Todos os escores cognitivos foram inferiores no grupo de pacientes. As médias de QI Total, QI Verbal e QI de Execução foram respectivamente 90,95 para o grupo de pacientes e 113,97 para os controles (p < 0,001); 91,41 para o grupo de pacientes e 112,31 para os controles (p < 0,001); 92,34 para o grupo de pacientes e 113,38 para os controles (p < 0,001). Os escores de velocidade de processamento, de resistência à distração e de organização perceptual foram, também, significativamente mais baixos nos pacientes. Detectou-se correlação direta e significativa entre o nível socioeconômico e os escores cognitivos. Em análise multivariada, para um mesmo nível socioeconômico, uma criança com anemia falciforme teve QI total, em média, 21,2 pontos mais baixo do que a média dos controles (p < 0,001), indicou que a doença, ajustada para o efeito socioeconômico, é forte fator preditivo do QI total. Conclusão: Os prejuízos cognitivos das crianças com anemia falciforme são intensos e se manifestam mesmo quando o efeito da doença é ajustado para o nível socioeconômico, o que, a nosso ver, requer abordagem preventiva precoce para tentar evitar tais prejuízos.


Subject(s)
Humans , Male , Female , Child , Adolescent , Cognition Disorders/etiology , Anemia, Sickle Cell/complications , Socioeconomic Factors , Wechsler Scales , Brazil , Case-Control Studies , Cross-Sectional Studies , Cognition Disorders/prevention & control , Intelligence Tests , Neuropsychological Tests
9.
Biomédica (Bogotá) ; 39(1): 22-32, ene.-mar. 2019. graf
Article in Spanish | LILACS | ID: biblio-1001386

ABSTRACT

Resumen Se reporta el proceso de recuperación y rehabilitación neurológica y cognitiva de una mujer joven que desarrolló un síndrome de embolia grasa con repercusiones neurológicas, después de sufrir un politraumatismo. La paciente era una mujer de 21 años de edad con fractura cerrada de húmero y fémur izquierdos, que presentó un síndrome de embolia grasa, neumotórax izquierdo e hipertensión pulmonar, en las primeras 24 horas después de un accidente. Estuvo hospitalizada un mes y quedó con varios déficits neurológicos centrales, como infartos 'lacunares' y necrosis cortical laminar occipital, así como limitaciones en la bipedestación, la marcha, la visión y las funciones cognitivas. A partir del primer mes después del alta hospitalaria, se comenzó un proceso integral de rehabilitación neurológica y cognitiva en casa, y posteriormente, en una unidad médica de rehabilitación. Durante los primeros dos años después del accidente, la paciente recibió estimulación sensorial, sensoperceptiva y motora, así como rehabilitación motora y visual intensiva. Una vez se recuperó físicamente, se inició un proceso de rehabilitación neuropsicológica. Seis años después del accidente, la paciente terminó sus estudios universitarios y hoy está laboralmente activa. El proceso de rehabilitación neurológica es complejo, individual y difícil, aunque no imposible, y no se puede estandarizar un patrón de recuperación para todos los pacientes. Si bien existe la recuperación espontánea, la cual se da en los primeros seis meses, el caso aquí reportado demuestra que, en la fase crónica, la recuperación se puede lograr, pero requiere de evaluaciones y técnicas coordinadas de rehabilitación neurológica.


Abstract We report the neurological and cognitive recovery and rehabilitation process in a young woman who developed a fat embolism syndrome with neurological repercussions secondary to multiple trauma. The patient was a 21-year-old woman with a closed fracture of the left humerus and femur. She developed fat embolism syndrome, left pneumothorax and pulmonary hypertension in the first 24 hours after the accident. After one month of hospitalization, the patient had several central neurological deficits such as lacunar infarcts and occipital laminar cortical necrosis, as well as limitations in standing, walking, vision, and cognitive functions. An integral process of neurological and cognitive rehabilitation--first at home and later in a medical rehabilitation unit-- was carried out from the first month after being released from the hospital. During the first two years after the accident, the patient received sensory and motor stimulation, motor rehabilitation, and intensive visual rehabilitation. Once recovered physically, a process of neuropsychological rehabilitation began. Six years after the accident, the patient finished her university studies and she is working actively. The neurological rehabilitation process is complex, individual and difficult, but not impossible, and a recovery pattern cannot be standardized for all patients. Although there is spontaneous recovery, which occurs in the first six months, the case here reported shows that in the chronic phase recovery can be achieved but requires evaluations and coordinated techniques of neurological rehabilitation.


Subject(s)
Female , Humans , Young Adult , Cognition Disorders/rehabilitation , Embolism, Fat/rehabilitation , Nervous System Diseases/rehabilitation , Cognition Disorders/etiology , Embolism, Fat/complications , Nervous System Diseases/etiology
10.
Rev. chil. neuropsicol. (En línea) ; 13(1): 47-51, ago. 2018. graf
Article in Spanish | LILACS | ID: biblio-1099484

ABSTRACT

La Leucemia Linfoblástica Aguda (LLA) infantil es el cáncer pediátrico más frecuente. Actualmente cuenta con un alto porcentaje de supervivencia, pero dichos pacientes presentan secuelas cognitivas secundarias a la enfermedad debidas, principalmente, al tratamiento médico recibido para evitar la recidiva del cáncer. Por lo tanto, resulta necesaria la implementación de programas de rehabilitación cognitiva específicos para este tipo de población. Es por ello que el objetivo del presente estudio fue describir los déficits cognitivos en un varón de 17 años que fue diagnosticado con LLA a los 9 años. Tras la valoración neuropsicológica inicial se desarrolló un programa de rehabilitación cognitiva intensivo durante dos años consecutivos. Realizamos un estudio pre-post en el que administramos el Conners Continuous Performance Test (CPT-II) y la Escala de Inteligencia de Wechsler para niños (WISC-IV). Los resultados, antes de la intervención, mostraron que el paciente manifestaba una menor velocidad de procesamiento y dificultades de atención sostenida y alternante, comprensión verbal y razonamiento perceptivo. Además, también presentó un número considerable de errores perseverativos, signo de dificultades de flexibilidad cognitiva y control inhibitorio. Dichos déficits mejoraron notablemente tras el programa de rehabilitación cognitiva. En conclusión, nuestro estudio pone de manifiesto la necesidad de aplicar programas de rehabilitación cognitiva tempranos para paliar las secuelas cognitivas derivadas de la LLA y de su tratamiento médico, así como mejorar la calidad de vida del paciente, ya que las mejoras cognitivas redundarán en su rendimiento académico y en su funcionamiento cotidiano.


Childhood Acute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer. It currently has a high survival rate, but these patients have cognitive sequelae secondary to the disease, mainly due to the medical treatment received to prevent cancer recurrence. Therefore, it is necessary to implement specific cognitive rehabilitation programs for this type of population. Hence, the main objective of this study was to describe cognitive deficits in a 17-year-old male who was diagnosed with ALL when he was 9 years old. After the initial neuropsychological evaluation, an intensive cognitive rehabilitation program was developed during two consecutive years. We conducted a pre-post study in which we administered the Conners Continuous Performance Test (CPT-II) and the Wechsler Intelligence Scale for Children (WISC-IV). Results, before the intervention, showed that the patient presented a lower processing speed and difficulties of sustained and alternating attention, verbal comprehension and perceptive reasoning; in addition to a large number of perseverative errors, sign of self-monitoring difficulties and inhibitory control. These deficits improved markedly after a program of cognitive rehabilitation. In conclusion, our study highlights the need to apply early cognitive rehabilitation programs to alleviate the cognitive sequelae derived from ALL and its medical treatment. In addition, any improvement in their cognitive capabilities will have a positive impact in their academic performance and quality of life.


Subject(s)
Humans , Male , Adolescent , Cognition Disorders/physiopathology , Cognition Disorders/rehabilitation , Precursor Cell Lymphoblastic Leukemia-Lymphoma/physiopathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/rehabilitation , Attention/physiology , Cognition Disorders/etiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Executive Function/physiology , Memory, Short-Term
11.
Article in Spanish | LILACS, CUMED | ID: biblio-901559

ABSTRACT

Introducción: Ante el envejecimiento acelerado de la población cubana los trastornos cognitivos se han convertido en creciente problema y un reto para nuestro sistema de salud. Objetivo: Describir la influencia de las determinantes del estado de salud de la población en el desarrollo de los trastornos cognitivos. Fuente de datos: Se consultaron 113 artículos en la Biblioteca Virtual Scielo y en las bases de datos Medline, Google Scholar, Cochrane y PubMed, en idioma Inglés y Español. Se seleccionaron 40, publicados en revistas nacionales e internacionales de gran impacto, por autores considerados expertos en esta temática. Síntesis de los datos: Además de factores biológicos y genéticos, existen determinantes psicosociales como el nivel educacional y los estilos de vida que pudieran incidir en la aparición y desarrollo de las demencias. Entre estos últimos, aparecen los hábitos tóxicos, las relaciones sociales, antecedentes de depresión, nivel socioeconómico y otros. Conclusiones: La influencia de los determinantes del estado de salud de la población en el desarrollo de los trastornos cognitivos, es notable. Es necesario el estudio de estos determinantes y su contribución a la puesta en marcha de estrategias de intervención comunitaria que ayuden, sobre todo, a la población más vulnerable a tener una mejor calidad de vida(AU).


Introduction: The accelerated aging of the Cuban population is an alert to the high prevalence of dementias and other chronic diseases. Objective: To describe the influence of health status determinants of the population in the development of cognitive disorders. Data source: 113 articles in the Scielo Virtual Library and in Medline, Google Scholar, Cochrane and PubMed databases were consulted, both in English and Spanish. 38 of the selected were published in national and international magazines of great impact, by authors considered experts in this subject. Synthesis of data: In addition to biological and genetic factors, there are other psychosocial determinants such as education and lifestyles that may have an impact on the onset and development of dementia. Among the latter are toxic habits, social interactions, sleep, and depressive states. These states may be considered as a psychological reaction to incipient cognitive worsening or as an early manifestation of dementia. Conclusions: The influence of population´s health status determinants in the development of cognitive disorders is remarkable. Given the accelerated aging of the Cuban population, cognitive disorders become a growing health problem. More research is needed and the results of this may contribute to a better understanding of the epidemiological behavior of these disorders. It is necessary, through intersectoral work, the implementation of community intervention strategies that help above all most vulnerable population to have a better life quality(AU)


Subject(s)
Humans , Male , Female , Quality of Life/psychology , Population Dynamics , Cognition Disorders/etiology , Cognition Disorders/ethnology , Cognition Disorders/epidemiology , Dementia/etiology , Social Determinants of Health/ethnology , Cognitive Aging/psychology , Cuba
12.
CoDAS ; 30(1): e20160255, 2018. tab, graf
Article in Portuguese | LILACS | ID: biblio-890817

ABSTRACT

RESUMO Objetivo Caracterizar o perfil dos quadros afásicos determinados pela hemorragia subaracnóidea aneurismática (HSA) da artéria cerebral média esquerda. Método Estudo analítico, retrospectivo, transversal, tendo como banco de dados as avaliações cognitivas de 193 pacientes do Hospital da Restauração com HSA aneurismática no período de março de 2007 a novembro de 2009. Destes, foram selecionados 26 pacientes com HSA em território da ACM-E, confirmada por angiografia digital. Os quadros afásicos foram classificados através do desempenho da linguagem dos pacientes através do Protocolo Montreal Toulose - Versão Alpha e a tarefa de fluência verbal da bateria CERAD. A pesquisa foi realizada no período de junho a agosto de 2015. Resultados Foi identificado comprometimento da linguagem e fluência verbal nos pacientes com HSA em território de ACM-E quando comparados com a população controle (50 indivíduos). Dos 26 pacientes com HSA, 11 apresentaram quadros afásicos ainda no período pré-operatório. Conclusão Os resultados da pesquisa corroboram com a literatura, mostrando que o quadro da HSA promove comprometimentos cognitivos ainda na fase pré-operatória para oclusão de aneurisma. Tendo em vista os aspectos observados, os quadros afásicos predominantes caracterizam afasia de compreensão por sequelas nas áreas cerebrais posteriores.


ABSTRACT Purpose Characterize the profile of aphasic syndromes determined by aneurysmal subarachnoid hemorrhage (aSAH) of the left middle cerebral artery (LMCA). Methods An analytical, retrospective, cross-sectional study was conducted using a database of cognitive assessments of 193 patients with aSAH admitted to Hospital da Restauração between March 2007 and November 2009. Of these, a total of 26 patients with aSAH in the LMCA territory confirmed by digital angiography were selected. Aphasia was assessed through the Montreal-Toulouse Language Assessment Alpha Version Protocol (Alpha Version) and the CERAD Neuropsychological Test Battery (Verbal fluency). Results Language and verbal fluency impairments were identified in patients with aSAH in the LMCA territory when compared with the control population (50 individuals). Of the 26 patients with aSAH, 11 presented aphasic characteristics preoperatively. Conclusion The results of this research corroborate the literature, showing that the aSAH frame causes cognitive impairments even in the preoperative phase for aneurysm occlusion. Considering the observed aspects, the predominant aphasic syndromes characterize comprehension aphasia due to sequels in the posterior cerebral artery territory.


Subject(s)
Humans , Male , Adult , Middle Aged , Aged , Aphasia/etiology , Subarachnoid Hemorrhage/complications , Intracranial Aneurysm/complications , Aphasia/classification , Cross-Sectional Studies , Retrospective Studies , Cognition Disorders/etiology , Educational Status
13.
Arq. neuropsiquiatr ; 75(6): 359-365, June 2017. tab, graf
Article in English | LILACS | ID: biblio-838921

ABSTRACT

ABSTRACT Research into memory and epilepsy has focused on measuring problems and exploring causes with limited attention directed at the role of neuropsychological rehabilitation in alleviating post-operative memory difficulties. Objectives To assess the effects of a memory rehabilitation program in patients with left temporal lobe epilepsy following surgery. Methods Twenty-four patients agreed to participate and 18 completed the study; nine received memory rehabilitation while nine had no input and were designated as controls. Verbal learning efficiency, naming abilities, memory subjective ratings, ecological activity measures and a language fMRI paradigm were used as outcome measures. Results Improved verbal learning and naming test performance, increase in memory strategy use and improved self-perception were observed following the rehabilitation. Changes in fMRI activation patterns were seen in the rehabilitation group over the long term. Conclusion The findings support the potential role of a cognitive rehabilitation program following left temporal lobe surgery.


RESUMO As publicações na área de epilepsia e memória se focam em mensurar prejuízos e investigar causas, com poucos dados sobre reabilitação neuropsicológica em pacientes pós-cirúrgicos. Objetivos Avaliar os efeitos da reabilitação neuropsicológica em pacientes submetidos a lobectomia temporal dominante. Métodos Vinte e quatro pacientes iniciaram o estudo, apenas dezoito o concluíram, dos quais 9 foram participantes de sessões de reabilitação com enfoque em memória. Todos os participantes foram avaliados quanto a autopercepção de dificuldades de memória; ao uso de estratégias para minimizar tais dificuldades; a habilidade de nomeação e a aprendizagem verbal e foram submetidos à ressonância magnética funcional. Resultados Foi encontrado efeito significativo da reabilitação neuropsicológica na autopercepção de dificuldades de memória; no uso de estratégias compensatórias; na aprendizagem verbal e na nomeação. Alterações no padrão de ativação na RMf foram observadas no grupo submetido a reabilitação. Conclusão A reabilitação neuropsicológica pode beneficiar pacientes submetidos a lobectomia temporal antero-mesial dominante com prejuízos de memória.


Subject(s)
Humans , Male , Female , Adult , Cognitive Behavioral Therapy/methods , Cognition Disorders/etiology , Cognition Disorders/rehabilitation , Anterior Temporal Lobectomy/rehabilitation , Epilepsy, Temporal Lobe/surgery , Signal Processing, Computer-Assisted , Brain Mapping , Magnetic Resonance Imaging/methods , Treatment Outcome , Educational Status , Neuropsychological Tests
14.
Arq. neuropsiquiatr ; 75(6): 394-401, June 2017. tab
Article in English | LILACS | ID: biblio-838919

ABSTRACT

ABSTRACT The existence of a benign multiple sclerosis (BMS) form is a controversial subject. Recent studies of these patients reveal different levels of cognitive impairment, despite the apparent preservation of motor function. The objective of this study was to review and analyze a number of publications that discuss the general aspects of this disease form, such as the definition criteria, prevalence, and clinical and neuroimaging markers. A systematic review of published data on BMS up to October 2015 was performed. Thirty-one published articles were analyzed. The estimated frequency of BMS varied between 6% and 73%. Cognitive impairment was recognized as affecting 17% to 47% of the subjects and presented significant correlation with neuroimaging, such as brain atrophy, increased lesion volume in T2 magnetic resonance assay, and regional grey matter atrophy. The current criteria overestimated the frequency of BMS and, for that reason, this highlights the importance of validating the diagnostic methods practiced.


RESUMO A existência real de uma forma benigna da esclerose múltipla (EMB) é um tema controverso. Ampliar o número de publicações que abordam os aspectos gerais do subtipo da doença, tais como os critérios de definição utilizados, análise de prevalência e da presença de marcadores clínicos e de neuroimagem. Foi realizada uma revisão sistemática dos dados publicados até outubro de 2015, relativa à EMB. Os dados encontrados foram dicotomizados em gráficos e, posteriormente, analisados. Foram analisados 31 artigos publicados. A frequência estimada EMB oscila entre 6% a 73%. O comprometimento cognitivo foi reconhecido em 17–47% dos sujeitos, apresentando correlação significativa com os aspectos de neuroimagem, como a atrofia cerebral global, aumento do volume lesional em T2 e atrofia regional da substância cinzenta. Os critérios atualmente utilizados superestimam a freqüência de EMB, e, por essa razão, destaca-se a importância da validação dos métodos de diagnóstico praticados.


Subject(s)
Humans , Cognition Disorders/etiology , Cognition Disorders/pathology , Cognition Disorders/diagnostic imaging , Multiple Sclerosis/complications , Multiple Sclerosis/pathology , Multiple Sclerosis/diagnostic imaging , Neuroimaging
15.
Neumol. pediátr. (En línea) ; 12(2): 66-70, abr. 2017. tab
Article in Spanish | LILACS | ID: biblio-999076

ABSTRACT

Sleeep disorder breathing (SDB) in chilhood includes a broad spectrum of disease ranging from primary snoring to more severe forms of obstructive sleep apnea syndrome. They may be associated with alterations different than those seen in adults, e.g., children present a low percentage of daytime sleepiness. Nevertheless, they present great difficulties in their learning, and failure in memory and attention and reports of behavior of aggressiveness. We analyze in the present review the cognitive and behavioral deficits asscoaited with the RDS and the main tests that are made for its study


Los trastornos respíratorios del sueño (TRS) en la infancia incluyen un amplio espectro que comprende desde el ronquido primario hasta las formas más graves de síndrome de apnea obstructiva del sueño (SAOS). Los niños presentan sintomatología asociada distinta a los adultos, como un bajo porcentaje de sonmolencia diurna. No obstante refieren dificultades en su aprendizaje, fallas en memoria, atención y cambios en su hiperactividad y agresividad. Se analizan los déficit cognitivos y conductuales asociados a los TRSy las principales pruebas neuropsicológicas o test que se realizan para su estudio


Subject(s)
Humans , Child , Sleep Apnea Syndromes/complications , Behavioral Symptoms/etiology , Cognition Disorders/etiology , Sleep Apnea Syndromes/diagnosis , Sleep Apnea Syndromes/etiology , Sleep Apnea Syndromes/physiopathology , Surveys and Questionnaires , Neuropsychology
16.
Rev. chil. neuro-psiquiatr ; 55(1): 52-63, abr. 2017. tab
Article in Spanish | LILACS | ID: biblio-844482

ABSTRACT

Introduction: Single suture craniosynostosis is the premature closure of one or more cranial sutures. It leads to abnormal skull growth and in some cases to structural and/or functional brain abnormalities. If these anomalies cause a psychomotor development lag and/or cognitive impairment is a controversial topic. This study aims to review the main findings related to psychomotor development and cognitive functioning in children with craniosynostosis, from birth to school age, dividing them into three stages: birth to 3 years, preschool and school. Method: An electronic search was made in PubMed from 2000 to 2015, using the following keywords: "craniosynostosis and neurodevelopment", "craniosynostosis and neuropsychological", "craniosynostosis and cognition". Results: In the early stage of life some children with craniosynostosis can have motor, language and cognition deficits; these impairments are also present in a variable percentage of preschool children, in some cases accompanied with behavior disorders; deficits in attention, executive functions and learning disorders, are reported in school years. Conclusion: Some neuropsychological alterations are found in a variable proportion of patients with craniosynostosis in all stages of development whichare revealed depending on the demands of each age. It is difficult to draw a cognitive profile for this population because of the heterogeneity related to characteristics of the sample, time of assessment, functions assessed and instrument used. It is important to make longitudinal neuropsychological assessments to know how children with craniosynostosis are developing in late stages and to develop consensus about cognitive functions and assessment instruments appropriate for each age.


Introducción: La craneosinostosis simple es el cierre prematuro de una o más suturas craneales que provoca crecimiento anormal del cráneo y en algunos casos anormalidades cerebrales estructurales y/o funcionales. Es un tema controversial si estas anormalidades causan el retraso psicomotor y/o cognitivo reportado en estos pacientes. Esta revisión tiene como objetivo abordar los hallazgos encontrados en el desarrollo psicomotor y cognitivo en niños con craneosinostosis, desde el nacimiento hasta la edad escolar, dividiéndolos en tres etapas: nacimiento a 3 años, etapa preescolar y escolar. Método: Se realizó una búsqueda en PubMed del 2000 al 2015, utilizando estas palabras claves: "craniosynostosis and neurodevelopment", "craniosynostosis and neuropsychological", "Craniosynostosis and cognition". Resultados: En las etapas tempranas de la infancia, los niños con craneosinostosis pueden tener deficiencias motoras, de lenguaje y cognitivas; estos déficits están presentes en un porcentaje variable en la etapa preescolar y pueden acompañarse de alteraciones conductuales; deficiencias atencionales, ejecutivas y de aprendizaje, se reportan en la edad escolar. Conclusión: Se reportan alteraciones neuropsicológicas en un porcentaje variable en estos pacientes en todas las etapas del desarrollo, que se van manifestando conforme las demandas del ambiente. Es difícil establecer un perfil neuropsicológico debido a la heterogeneidad de las características de las muestras en los estudios, el tiempo de la evaluación, las funciones estudiadas y los instrumentos utilizados. Es importante realizar un seguimiento longitudinal para conocer el desarrollo de estos niños, así como el hacer un consenso sobre las funciones cognitivas a evaluar e instrumentos a utilizar para cada edad.


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Cognition Disorders/epidemiology , Craniosynostoses/epidemiology , Cognition Disorders/etiology , Cognition/physiology , Craniosynostoses/complications , Neuropsychology
17.
Medicina (B.Aires) ; 77(2): 117-120, Apr. 2017. tab
Article in Spanish | LILACS | ID: biblio-894443

ABSTRACT

La miastenia gravis es una enfermedad crónica, autoinmune que afecta la transmisión neuromuscular. Se han comunicado hallazgos contradictorios acerca del deterioro cognitivo en dicha enfermedad. El objetivo del presente estudio fue investigar el patrón cognitivo de pacientes con miastenia gravis. Participaron 24 pacientes con miastenia gravis, anticuerpos anti-receptor de acetilcolina (ACRA) positivos, y 24 controles. Pacientes: edad 43.9 ± 14.8, años de escolaridad 10.9 ± 3.3. Controles: edad 44.5 ± 15.4, años de escolaridad 11.5 ± 3.3. Se evaluaron las siguientes áreas: memoria verbal: (largo plazo almacenamiento, recuperación y recuerdo diferido) del test selectivo de memoria; atención: Paced Auditory Serial Addition Task (PASAT, 2 y 3 segundos); funciones ejecutivas (FE): analogías y secuencia números-letras. Se administró además el Inventario de Depresión de Beck II (IDB II). El 33.3% de los pacientes obtuvo un desempeño anómalo en dos o más test cognitivos. El 37.5% mostró deterioro en atención; 33.3% en memoria verbal; 29.2% en FE. Se encontraron diferencias significativas entre pacientes y controles en almacenamiento (p = 0.001); recuperación (p = 0.007); recuerdo diferido (p = 0.000); PASAT 3 (p = 0.009); PASAT 2 (p = 0.009); analogías (p = 0.003). Se encontró evidencia de depresión: leve en el 4.2 %; moderada en el 25% y grave en el 29.2%. El rendimiento neuropsicológico declina en los pacientes con miastenia gravis, encontrándose mayor alteración en la atención que en el resto de las áreas cognitivas.


Myasthenia gravis is a chronic autoimmune disease that affects the neuromuscular transmission. Controversial findings had been reported about cognitive impairment in this disease. The aim of this study was to investigate the cognitive pattern of patients with myasthenia gravis. There were enrolled 24 patients with myasthenia gravis, anti-acetylcholine receptor antibodies (ACRA) positive, and 24 healthy controls. Patients: age 43.9 ± 14.8, years of education 10.9 ± 3.3. Controls: age 44.5 ± 15.4, years of education 11.5 ± 3.3. The following areas were evaluated: verbal memory: (long-term storage, retrieval, delayed recall) of the Selective Remained Test; attention: Paced Auditory Serial Addition Task (PASAT 2 and 3 seconds); executive functions: analogies and numbers-letters sequence. Also, it was administered the Beck Depression Inventory II (BDI II). About 33.3% of patients obtained abnormal performance in two or more cognitive tests. 37.5% showed deterioration in attention; 33.3% in verbal memory; 29.2% in executive functions. Significant differences between patients and healthy controls were found in long-term storage (p = 0.001); retrieval (p = 0.007); delayed recall (p = 0.000); PASAT 3 (p = 0.009); PASAT 2 (p = 0.009) and analogies (p = 0.003). Evidence of depression was found: mild in 4.2% of patients; moderate in 25% and severe in 29.2%. Neuropsychological performance declines in patients with myasthenia gravis: attention was more affected than other cognitive areas.


Subject(s)
Humans , Male , Female , Adult , Cognition Disorders/etiology , Depression/etiology , Myasthenia Gravis/complications , Psychiatric Status Rating Scales , Case-Control Studies , Cognition Disorders/diagnosis , Educational Status , Neuropsychological Tests
18.
Rev. bras. neurol ; 53(1): 5-14, jan.-mar. 2017. tab
Article in English | LILACS | ID: biblio-832724

ABSTRACT

Neurocysticercosis (NCC) is the brain infection caused by larval stages of the helminth Taenia solium. The embryos of Taenia travel through the bloodstream and can reach the brain, muscles, eyes, and various organs. In the brain, the psychiatric manifestations are mood disorders, depression and anxiety, which are commonly associated with epilepsy and sensory-motor deficits. Neurocysticercosis is a frequent parasitic disease in the world population; it is endemic in Central and South America, Asia and Sub-Saharan Africa. In the present review, we report the major symptoms and signals of neurocysticercosis common to neurological and psychiatric illnesses. We briefly present Epidemiology of those manifestations and analyze the relationship between pathological changes and NCC symptomatology. OBJECTIVES AND METHODOLOGY: A literature review was conducted to characterize epidemiological, neurological and psychiatric manifestations of NCC. The final 90 papers were selected of a set of 937 publications from 2010 to 2016. RESULTS: NCC is a major cause of epilepsy in endemic areas; further- more, leads to a diversity of motor and sensitive deficits, manifestations vary from headache to severe intracranial hypertension. Potentially fatal conditions include arteritis, encephalitis and hydrocephalus. Depression and cognitive decline remain among the most important psychiatric manifestations. Neuropsychiatric manifestations, Epidemiology, and neuroimaging provide diagnostic criteria. Brain scans may reveal one or diverse cysts filled with fluid within a scolex (parasite's head). CONCLUSION: NCC's diversity of presentations encourage health professionals to consider it in diagnoses, especially in endemic countries, and also in non-endemic areas because migrants and travelers are subject to contagious. Treatment consists in use of antiparasitic drugs (albendazol, praziquantel) and drugs to treat associated conditions (anticonvulsants, corticosteroids). Surgery is reserved to extirpate the parasite from particular locations (eyes, spinal cord, cerebral ventricles) or to differentiate NCC from tumors, tuberculosis, mycosis, etc. Prevention includes treatment of intestinal helminthiasis, sanitation in animal farming, food preparing hygiene, quality control of water and food.


Neurocisticercose é a infecção cerebral causada pelos estágios lar- vais do helminto Taenia solium. Os embriões da Taenia deslocam-se através da corrente sanguínea e podem atingir o cérebro, músculos, olhos e vários órgãos. No cérebro, as manifestações psiquiátricas são transtornos de humor, depressão e ansiedade, as quais estão comumente associados com epilepsia e deficiências sensório-motoras. Neurocisticercose é uma parasitose frequente na população mundial, é endêmica na América Central e do Sul, Ásia e África subsaariana. Na presente revisão, relatamos os principais sintomas e sinais de neurocisticercose pertinentes a doenças neurológicas e psiquiátricas. Nós brevemente apresentamos a Epidemiologia dessas manifestações, e analisamos a relação entre alterações patológicas e sintomatologia da NCC. OBJETIVOS E METODOLOGIA: Uma revisão da literatura foi conduzida para caracterizar a epidemiologia, as manifestações neurológicas e psiquiátricas de NCC. Os 90 artigos finais foram selecionados de um conjunto de 937 publicações entre 2010 a 2016. RESULTADOS: NCC é uma importante etiologia de epilepsia em áreas endêmicas, além disso causa uma diversidade de deficiências motoras e sensoriais, as manifestações variam de cefaleia a severa hipertensão intracraniana. Condições potencialmente fatais incluem arterites, encefalites e hidrocefalia. Depressão e declíneo cognitive permanecem entre as mais importantes manifestações psiquiátricas. Manifestações neuropsiquiátricas, epidemiologia e neuroimagem provêm os critérios de diagnóstico. As imagens cerebrais podem revelar um ou diversos cistos preenchidos com líquido e o escólex (cabeça) do parasito. CONCLUSÕES: A diversidade de apresentações da NCC encoraja os profissionais de saúde a considerá-la dentre os diagnósticos, especialmente em países endêmicos; e também em áreas não-endêmicas, pois migrantes e viajantes estão sujeitos ao contágio. O tratamento consiste no uso de antiparasíticos (albendazol, praziquantel) e medicamentos para tratar condições associadas (anticonvulsivantes, corticosteróides). Cirurgia é reservada para remoção do parasito de locais particulares (olhos, medula espinhal, ventrículos cerebrais) ou para diferenciar NCC de tumores, tuberculose, micose, etc. Prevenção inclui o tratamento de helmintíases intestinais, sanidade animal, higiene ao preparar alimentos, controle da qualidade da água e alimentos.


Subject(s)
Humans , Neurocysticercosis/complications , Neurocysticercosis/diagnosis , Neurocysticercosis/epidemiology , Praziquantel/therapeutic use , Albendazole/therapeutic use , Incidence , Cognition Disorders/etiology , Neurocysticercosis/drug therapy , Taenia solium/pathogenicity , Depression/etiology , Epilepsy/etiology , Neuroimaging/methods , Hydrocephalus/etiology
19.
Rev. Hosp. Clin. Univ. Chile ; 28(3): 209-218, 20170000. tab
Article in Spanish | LILACS | ID: biblio-970542

ABSTRACT

Cognitive function may decline after surgical procedures. Cognitive postoperative dysfunction (CPOD) is subtle and requires neuropsychological test for diagnosis. Multifactorial in origin, its cause is unknown but associated with different risk factors, which especially affects origin people submitted to extense surgery. CPOD is transient, but in some cases is prolonged and is associated with an increase in mortality and permanente disability. The aging population and the increase of elderly patients requiring surgery a cause of concern. Clinical studies are required to recognize preventive and therapeutic measures to reduce CPOD in the future. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Postoperative Complications/etiology , Cognition Disorders/etiology , Cognition Disorders/diagnosis , Delirium/etiology
20.
Rev. bras. neurol ; 52(4): 5-17, out.-dez. 2016. graf, ilus, tab
Article in Portuguese | LILACS | ID: biblio-831609

ABSTRACT

A Doença de Alzheimer (DA) é uma doença cerebral degenerativa que atinge normalmente a população idosa e que provoca declínio cognitivo. Pacientes acometidos por essa doença tendem a sofrer de disfagia, podendo surgir deficiências nutricionais, com consequente perda de peso, o que dificulta o tratamento de modo geral. Diante desse fato, o principal objetivo deste artigo é avaliar os resultados da interferência da nutrição em pacientes portadores de DA. Foram analisados parâmetros antropométricos, dietéticos e bioquímicos em ambos os sexos. Com base nos resultados apresentados no que diz respeito ao sexo, obteve-se uma média de idade de 84 anos entre os sexos, com maior prevalência no gênero feminino, totalizando 73% do total da amostra de 51 participantes. Na análise do inquérito alimentar, o consumo médio de energia e de macronutrientes dos idosos do sexo masculino foi de 1247,88 kcal, distribuídos 128,62g de carboidratos, 44,80g de proteínas e 20,66g de lipídeos, enquanto no sexo feminino foi de 1229,01 kcal, distribuídos em 137,61g de carboidratos, 44,58g de proteínas e 23,12g de lipídeos. Portanto, conclui-se que é fundamental a atuação de uma equipe interdisciplinar para a integração de conhecimento de várias áreas, com o objetivo comum de promoção e reabilitação da saúde dos idosos.


Alzheimer's disease (AD) is a degenerative brain disease that usually strikes the elderly and causes cognitive decline. Patients affected by this disease tend to suffer from dysphagia, and there may be nutritional deficiencies, with consequent weight loss, wich difficult the treament in general. Given this fact, the main purpose of this article is to evaluate the results of the interference of nutrition in patients with AD. Anthropometric, dietary and biochemical parameters in both sexes were analyzed. Based on the results presented in relation to sex, there was obtained a mean age of 84 years between the sexes, with a higher prevalence in females, totaling 73% of the total sample of 51 participants. In the food survey analysis, the average intake of energy and macronutrients of elderly men was 1247,88 kcal, distributed 128,62g of carbohydrates, 44,80g of proteins and 20,66g of lipids, while the female sex was of 1229,01 kcal, distributed in 137,61g of carbohydrates, 44,58g of proteins and 23,12 of lipids. Therefore, it is concluded that it is essential the work of an interdisciplinary team to integrate knowledge from different areas, with the common goal of promotion and health rehabilitation of the elderly.


Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Nutrition Assessment , Nutritional Status , Frail Elderly/psychology , Alzheimer Disease/complications , Alzheimer Disease/diagnosis , Deglutition Disorders/etiology , Geriatric Assessment/methods , Anthropometry , Epidemiology, Descriptive , Cognition Disorders/etiology , Nutritional Requirements
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