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1.
Article in English | WPRIM | ID: wpr-223107

ABSTRACT

Ovarian mucinous tumors in <15 years old are rare with <50 cases reported till date in the literature. Majority of them are benign or borderline epithelial ovarian tumors with only 12 cases of cystadenocarcinomas reported at a young age. We report a case of mucinous cystadenocarcinoma in 14-year-old girl with metastasis to omentum at the time of presentation. Management of such cases is tricky as conservative approach sparing fertility of the patient is adopted. This case is presented for its rarity and unique presentation. To the best of our knowledge, this is the thirteenth case of ovarian cystadenocarcinoma being reported at a very young age and the first case being reported from Indian subcontinent. Extensive review of the previously published cases in the literature has been done in this study.


Subject(s)
Adolescent , Cystadenocarcinoma , Cystadenocarcinoma, Mucinous , Female , Female , Fertility , Humans , Mucins , Neoplasm Metastasis , Omentum , Ovary
2.
Article in English | WPRIM | ID: wpr-786927

ABSTRACT

A 63-year-old male with a recently diagnosed right lung lesion was referred for staging. F-FDG PET/CT scan revealed a hypodense, cystic-like mass in the right upper lung lobe, which demonstrated low, diffuse ¹⁸F-FDG uptake, likely due to the presence of mucus, as well as intensely hypermetabolic right hilar and right paratracheal lymph nodes. Transbronchial biopsy revealed a primary pulmonary mucinous cystadenocarcinoma with the presence of signet ring cell carcinoma, a co-existence of two rare variants of lung adenocarcinoma. This case report demonstrates the metabolic phenotype along with the radiographic characteristics of this rare tumor and its metastases.


Subject(s)
Adenocarcinoma , Biopsy , Carcinoma, Signet Ring Cell , Cystadenocarcinoma, Mucinous , Fluorodeoxyglucose F18 , Humans , Lung , Lung Neoplasms , Lymph Nodes , Male , Middle Aged , Mucins , Mucus , Neoplasm Metastasis , Phenotype , Positron-Emission Tomography , Positron Emission Tomography Computed Tomography
3.
Article in English | WPRIM | ID: wpr-72150

ABSTRACT

OBJECTIVE: Ovarian needle aspiration and biopsy (ONAB) may be employed for pretreatment diagnosis of ovarian malignancies or intraoperatively to facilitate removal of ovarian masses. However, there is reluctance to utilize this procedure due to potential cyst rupture or seeding of malignant cells. The objective of this study was to examine the efficacy of ONAB over a 13-year period at our institution. METHODS: Between 2000 and 2013, all ONAB specimens were identified from the Queen's Medical Center Pathology Department database. All cytologic specimens were reviewed and correlated with histopathologic findings. A retrospective chart review was conducted to retrieve data on clinical course and treatment. RESULTS: This study identified 144 cases of ovarian masses sampled by aspiration or needle biopsy between 2000 and 2013. Ninety-two (64%) cases had corresponding histopathology, 84 (91%) of which were obtained concomitantly. On histology, 12 (13%) cases were malignant and 80 (87%) benign. Three false negative cases were noted; 2 serous borderline tumors and 1 mucinous cystadenocarcinoma. These were sampling errors; no diagnostic tumor cells were present in the aspirates. Sensitivity and specificity of ONAB in the detection of malignancy were 75% and 100%, respectively. The positive and negative predictive values were 100% and 96%, respectively. CONCLUSION: ONAB represents a valuable tool in the diagnosis of malignancy and treatment of ovarian masses. In our study, it was highly specific, with excellent positive and negative predictive value.


Subject(s)
Biopsy , Biopsy, Needle , Cystadenocarcinoma, Mucinous , Diagnosis , Needles , Ovarian Neoplasms , Pathology , Retrospective Studies , Rupture , Selection Bias , Sensitivity and Specificity
4.
Rev. chil. cir ; 68(4): 319-322, jul. 2016. ilus
Article in Spanish | LILACS | ID: lil-788901

ABSTRACT

Objetivo Exposición de 3 casos tratados quirúrgicamente en nuestra clínica. Casos clínicos Caso 1: paciente mujer de 78 años con diagnóstico de quiste complejo de ovario derecho, se realizó la cirugía y se evidencia tumoración de apéndice cecal. Caso 2: paciente varón de 38 años con dolor abdominal crónico. Presenta marcador tumoral antígeno carcinoembrionario elevado, laparoscopia exploratoria evidencia líquido mucinoso peritoneal y tumoración apendicular. Caso 3: paciente mujer de 42 años con dolor crónico en fosa iliaca derecha con marcadores tumorales normales. Laparoscopia exploratoria evidencia tumoración dependiente del apéndice cecal con localización retrocecal ascendente. Discusión Se debe considerar a los mucoceles apendiculares dentro del diagnóstico diferencial de dolor en cuadrante inferior derecho del abdomen. Es preferible realizar una hemicolectomia radical para lesiones grandes y/o perforadas por el riesgo de existir cistoadenocarcinoma. El abordaje laparoscópico es una buena alternativa de manejo.


Objective We present three surgically treated cases in our hospital Case Reports Case 1: A 78 years old woman with a diagnosis of complex ovarian cyst. During surgery, an appendicular tumor was found. Case 2: A 38 years old male with chronic abdominal pain with high levels of carcinoembryonic antigen. During exploratory laparoscopy an appendicular tumor and mucinous peritoneal fluid were found. Case 3: A 42 years old woman with chronic pain in the right lower abdomen, negative tumor markers. During exploratory laparoscopy a retrocecal appendicular tumor was found. Discussion Appendiceal mucoceles should be considered in the differential diagnosis of right lower abdominal pain. If the lesions are big or perforated, a radical hemicolectomy should be performed due to the risk of a cystadenocarcinoma. Laparoscopic approach is a good alternative for management.


Subject(s)
Humans , Male , Female , Adult , Aged , Appendiceal Neoplasms/surgery , Laparoscopy , Cystadenocarcinoma, Mucinous/surgery , Appendiceal Neoplasms/diagnosis , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Abdominal Pain/etiology , Cystadenocarcinoma, Mucinous/diagnosis
5.
Article in English | WPRIM | ID: wpr-26776

ABSTRACT

Mucinous cystadenocarcinoma (MC) of the kidney is a rare epithelial tumor originating from the renal pelvic urothelium and few study cases have been reported. Because of the rarity of these tumors and their unknown histogenesis, its diagnosis is difficult until surgical exploration. We report here on a 55-year-old man referred to the urology department from the hepatology department because of a cystic renal mass measuring approximately 5 cm in size, which was detected incidentally under ultrasonography during the routine examination of liver. The renal mass was finally diagnosed as MC originating from kidney after partial nephrectomy and the patient still showed no evidence of recurrence until 12 months postoperatively. This is the first report on a case of renal MC in a patient who underwent partial nephrectomy. The aim of this report is to present our unusual case of MC and also review the previous literature on the pathological and radiological aspects of MC of kidney.


Subject(s)
Cystadenocarcinoma, Mucinous , Diagnosis , Gastroenterology , Humans , Kidney , Liver , Middle Aged , Mucins , Nephrectomy , Recurrence , Ultrasonography , Urology , Urothelium
6.
Journal of Breast Cancer ; : 330-333, 2016.
Article in English | WPRIM | ID: wpr-126235

ABSTRACT

Primary mucinous cystadenocarcinoma (MCA) of the breast is a rare but pathologically distinct breast tumor. There have been some case reports on primary MCA of the breast; however, they have all focused on pathologic findings. Here, we report the radiologic findings of two cases of MCA along with a review of the literature. Breast MCA shows a circumscribed mass with some calcifications on mammography, an intracystic solid mass without increased vascularity or a vascular stalk on ultrasound, and a heterogeneously enhancing mass within a rim-enhancing cyst with intermediate signal intensity on T2-weighted magnetic resonance imaging. These radiologic findings and the presence of mucin in the percutaneous biopsy specimen should suggest the possibility of MCA in the differential diagnosis of a breast tumor.


Subject(s)
Biopsy , Breast Neoplasms , Breast , Cystadenocarcinoma, Mucinous , Diagnosis, Differential , Magnetic Resonance Imaging , Mammography , Mucins , Ultrasonography
7.
Article in English | WPRIM | ID: wpr-98133

ABSTRACT

The pancreatic cystic lesions are known to be incidentally found up to 10-15% of patients undergoing cross-sectional imaging. And the prevalence of mucinous cystic neoplasm which has malignant potential is known to be up to 25% of all pancreatic cystic neoplasm in South Korea. The symptoms included abdominal pain, palpable mass, weight loss, loss of appetite, jaundice, asymptomatic and etc. However, spontaneous rupture of pancreatic mucinous cystadenocarcinoma (MCAC) is an extremely rare complication. Here we report a case of spontaneous rupture of pancreatic MCAC in a 72-year-old male with review of the literature. To the best of our knowledge, this is the first ruptured case of pancreatic MCAC in male patient.


Subject(s)
Abdominal Pain , Aged , Appetite , Cystadenocarcinoma, Mucinous , Humans , Jaundice , Korea , Male , Mucins , Pancreas , Pancreatic Cyst , Prevalence , Rupture , Rupture, Spontaneous , Weight Loss
8.
Chinese Journal of Cancer ; (12): 50-55, 2015.
Article in English | WPRIM | ID: wpr-349612

ABSTRACT

Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.


Subject(s)
Carcinoma, Endometrioid , Pathology , Cystadenocarcinoma, Mucinous , Pathology , Cystadenocarcinoma, Serous , Pathology , Female , Humans , Mixed Tumor, Malignant , Pathology , Neoplasms, Glandular and Epithelial , Pathology , Ovarian Neoplasms , Genetics , Pathology
9.
Clinical Endoscopy ; : 328-331, 2015.
Article in English | WPRIM | ID: wpr-22767

ABSTRACT

Secondary achalasia or pseudoachalasia is a rare esophageal motor abnormality, which mimics primary achalasia; it is not easily distinguishable from idiopathic achalasia by manometry, radiological examination, or endoscopy. Although the majority of reported pseudoachalasia cases are associated with neoplasms at or near the esophagogastric (EG) junction, other neoplastic processes or even chronic illnesses such as rheumatoid arthritis can lead to the development of pseudoachalasia, for example, mediastinal masses, gastrointestinal (GI) tumors of the liver and biliary tract, and non-GI malignancies. Therefore, even if a patient presents with the typical findings of achalasia, we should be alert to the possibility of other GI malignancies besides EG tumors. For instance, pancreatic cancer was found in the case reported here; only four such cases have been reported in the literature. A 47-year-old man was admitted to our center with a 3-month history of dysphagia. His endoscopic and esophageal manometric findings were compatible with primary achalasia. However, unresponsiveness to diverse conventional achalasia treatments led us to suspect secondary achalasia. An active search led to a diagnosis of pancreatic mucinous cystadenocarcinoma invading the gastric fundus and EG junction. This rare case of pseudoachalasia caused by pancreatic carcinoma emphasizes the need for suspecting GI malignancies other than EG tumors in patients refractory to conventional achalasia treatment.


Subject(s)
Arthritis, Rheumatoid , Biliary Tract , Chronic Disease , Cystadenocarcinoma, Mucinous , Deglutition Disorders , Diagnosis , Endoscopy , Esophageal Achalasia , Gastric Fundus , Humans , Liver , Manometry , Middle Aged , Neoplastic Processes , Pancreatic Neoplasms
10.
Rev. colomb. cancerol ; 18(2): 83-87, abr.-jun. 2014. ilus
Article in Spanish | LILACS | ID: lil-726891

ABSTRACT

Los tumores derivados de células germinales representan el 20-25% de tumores ováricos, siendo sólo 3% malignos. La degeneración maligna se presenta únicamente en 1-2% de los casos. La edad de presentación promedio de la transformación maligna es a los 50 años, siendo los más frecuentes el carcinoma de células escamosas y el adenocarcinoma (1). Dado que la supervivencia a largo plazo se encuentra en relación con la detección temprana y la completa resección quirúrgica, se hace necesario determinar las características clínico-patológicas que sugieran una posible transformación maligna de estos tumores. A continuación, se presenta el caso de una paciente perimenopáusica, con hallazgos histopatológicos indicativos de transformación maligna de un teratoma quístico maduro a cistoadenocarcinoma mucinoso bien diferenciado de tipo endocervical e intestinal.


The germ cell-derived tumors account for 20-25% of ovarian tumors, with 3% being malignant. The degeneration occurs in 1-2% of cases. The age of presentation is menopause, around the age 50, and the most common malignant histological types in this context are squamous cell carcinoma and adenocarcinoma. It is important to determine the clinical-pathological characteristics of malignant transformation (although currently not well established), as because early detection and complete surgical resection are important for long-term survival. A case is presented on a peri-menopausal woman with histopathological findings of malignant transformation of a mature cystic teratoma to well-differentiated mucinous cystadenocarcinoma endocervical and intestinal type.


Subject(s)
Humans , Female , Ovary , Teratoma , Carcinoma, Squamous Cell , Cystadenocarcinoma, Mucinous , Adenocarcinoma, Mucinous , Women , Survivorship , Germ Cells
11.
Chinese Journal of Cancer ; (12): 87-95, 2014.
Article in English | WPRIM | ID: wpr-320561

ABSTRACT

Pancreatic pseudocysts are the most common cystic lesions of the pancreas and may complicate acute pancreatitis, chronic pancreatitis, or pancreatic trauma. While the majority of acute pseudocysts resolve spontaneously, few may require drainage. On the other hand, pancreatic cystic tumors, which usually require extirpation, may disguise as pseudocysts. Hence, the distinction between the two entities is crucial for a successful outcome. We conducted this study to highlight the fundamental differences between pancreatic pseudocysts and cystic tumors so that relevant management plans can be devised. We reviewed the data of patients with pancreatic cystic lesions that underwent intervention between June 2007 and December 2010 in our hospital. We identified 9 patients (5 males and 4 females) with a median age of 40 years (range, 30-70 years). Five patients had pseudocysts, 2 had cystic tumors, and 2 had diseases of undetermined pathology. Pancreatic pseudocysts were treated by pseudocystogastrostomy in 2 cases and percutaneous drainage in 3 cases. One case recurred after percutaneous drainage and required pseudocystogastrostomy. The true pancreatic cysts were serous cystadenoma, which was treated by distal pancreatectomy, and mucinous cystadenocarcinoma, which was initially treated by drainage, like a pseudocyst, and then by distal pancreatectomy when its true nature was revealed. We conclude that every effort should be exerted to distinguish between pancreatic pseudocysts and cystic tumors of the pancreas to avoid the serious misjudgement of draining rather than extirpating a pancreatic cystic tumor. Additionally, percutaneous drainage of a pancreatic pseudocyst is a useful adjunct that may substitute for surgical drainage.


Subject(s)
Adult , Aged , Cystadenocarcinoma, Mucinous , Diagnostic Imaging , Pathology , General Surgery , Cystadenoma, Serous , Diagnostic Imaging , Pathology , General Surgery , Diagnostic Errors , Drainage , Female , Humans , Male , Middle Aged , Pancreatectomy , Pancreatic Cyst , Diagnostic Imaging , Pathology , General Surgery , Pancreatic Neoplasms , Diagnostic Imaging , Pathology , General Surgery , Pancreatic Pseudocyst , Diagnostic Imaging , Pathology , General Surgery , Retrospective Studies , Tomography, X-Ray Computed
12.
Rev. chil. cir ; 65(1): 60-63, feb. 2013. ilus
Article in Spanish | LILACS | ID: lil-665557

ABSTRACT

Introduction: Appendiceal mucocele are lesions located in the cecum, which are found in 0.2 to 0.3 percent of appendectomies and correspond to 8-10 percent of all appendiceal tumors. Clinical case: We report a 83 years old female consulting for abdominal pain lasting 24 hours. On physical examination, signs of peritoneal irritation were found. The patient was operated, finding an appendiceal tumor that was coiled up in the mesentery with large bowel gangrene. An intestinal resection, terminal ileostomy, appendectomy and surgical lavage were performed. The pathological study of the surgical piece reported a mucinous cystadenoma.


Introducción: Los tumores del Apéndice Cecal corresponden al 0,5 por ciento de las neoplasias gastrointestinales y se encuentran entre el 0,8 por ciento y el 1 por ciento de las apendicectomías. El término Mucocele Apendicular (AM), se refiere a un grupo de lesiones localizados a nivel del ciego cuyo rango de incidencia está entre el 0,2 por ciento y el 0,3 por ciento de todas las apendicectomías, y entre el 8-10 por ciento de todos los tumores apendiculares. Las presentaciones clínicas más frecuentes son: cuadro clínico de apendicitis aguda, como hallazgo incidental como en el caso de esta paciente, o como masa abdominal en fosa ilíaca derecha. Caso clínico: Se presenta un caso de Cistade-noma Mucinoso Apendicular (CAM) encontrado como hallazgo incidental en un abdomen agudo quirúrgico con la particularidad de presentarse con una necrosis intestinal.


Subject(s)
Humans , Female , Aged, 80 and over , Cystadenocarcinoma, Mucinous/surgery , Cystadenocarcinoma, Mucinous/complications , Intestinal Diseases/etiology , Gangrene/etiology , Appendiceal Neoplasms/surgery , Appendiceal Neoplasms/complications , Appendicitis , Intestinal Diseases/surgery , Gangrene/surgery , Intestines/pathology , Necrosis
13.
Article in Chinese | WPRIM | ID: wpr-232733

ABSTRACT

<p><b>OBJECTIVE</b>To study the application of three-dimensional visualization technology for laparoscopic resection of cystic carcinoma in the pancreatic body and tail.</p><p><b>METHODS</b>Six cases of cystic carcinoma in the pancreatic body and tail treated between Nov, 2009 and Mar, 2011 were retrospectively analyzed. The original image data of 64-slice spiral CT were collected and using adaptive region growing algorithm, the serial CT images were segmented and automatically extracted to obtain the 3-dimensional reconstruction images with customized image manipulation software. The specific surgical approach (the trocar position) and surgical procedure were planned based on the reconstructed mode.</p><p><b>RESULTS</b>The reconstructed 3-dimensional model clearly displayed cystic carcinoma in the pancreatic body and tail and the adjacent organs, showing distinct relationship between the cystoma and the splenic artery and vein. All the patients successfully underwent laparoscopic resection of the pancreatic body and tail without perioperative death. The spleen was preserved in 5 cases and removed in 1 case due to mucinous cystadenocarcinoma. The overall rate of pancreatic fistulae was 33.3% without incidences of postoperative hemorrhage. The average hospital stay of the patients was 12 days.</p><p><b>CONCLUSION</b>Three-dimensional reconstruction based on pancreatic CT data provides valuable assistance for laparoscopic resection of cystic carcinoma in the pancreatic body and tail.</p>


Subject(s)
Adult , Aged , Computer Simulation , Cystadenocarcinoma, Mucinous , Diagnostic Imaging , General Surgery , Cystadenoma, Mucinous , Diagnostic Imaging , General Surgery , Cystadenoma, Serous , Diagnostic Imaging , General Surgery , Female , Humans , Imaging, Three-Dimensional , Laparoscopy , Methods , Length of Stay , Male , Middle Aged , Pancreas , Diagnostic Imaging , General Surgery , Pancreatectomy , Methods , Pancreatic Fistula , Pancreatic Neoplasms , Diagnostic Imaging , General Surgery , Retrospective Studies , Spleen , General Surgery , Tomography, Spiral Computed
14.
Intestinal Research ; : 60-65, 2013.
Article in Korean | WPRIM | ID: wpr-112033

ABSTRACT

Sarcomatoid carcinoma or carcinosarcoma is a very rare biphasic tumor characterized by a combination of malignant epithelial and mesenchymal cells. The pathogenesis of sarcomatoid carcinoma is not fully elucidated and the guideline of treatment has not been established yet. Although the upper aerodigestive tract, lung and female urogenital system are known to be the most frequently affected, this tumor also can occur in various sites, including the digestive tract. Since sarcomatoid carcinoma in colon was firstly reported in 1986, 24 cases have been reported to date. We report a rare case with sarcomatoid carcinoma of appendix. Interesting histologic feature of our case was the presence of mucinous cystadenocarcinoma with morphological "transition" between carcinomatous and sarcomatous tissue. To our knowledge, this is the first case of sarcomatoid carcinoma arising from mucinous cystadenocarcinoma of the appendix.


Subject(s)
Appendix , Carcinosarcoma , Colon , Cystadenocarcinoma, Mucinous , Female , Gastrointestinal Tract , Humans , Lung , Mucins , Urogenital System
15.
Article in English | WPRIM | ID: wpr-74079

ABSTRACT

A pulmonary mucinous cystadenocarcinoma is an extremely rare tumor that is considered to be a cystic variant of mucin-producing lung adenocarcinoma. We present a case of pulmonary mucinous cystadenocarcinoma in a 54-year-old woman. Chest CT scans showed a 4.3-cm-sized, lobulated, well-defined, and homogeneous mass in the right middle lobe with peripheral stippled calcifications that demonstrated low-attenuation with no enhancement after contrast administration; 18F-fluorodeoxyglucose (FDG) PET/CT demonstrated mild heterogeneous FDG uptake. The mass was diagnosed as adenocarcinoma with mucin production by transbronchial lung biopsy. Right middle lobectomy was performed, and the pathologic examination disclosed a pulmonary mucinous cystadenocarcinoma.


Subject(s)
Cystadenocarcinoma, Mucinous/pathology , Diagnosis, Differential , Female , Fluorodeoxyglucose F18 , Humans , Lung Neoplasms/pathology , Middle Aged , Positron Emission Tomography Computed Tomography , Radiopharmaceuticals , Tomography, X-Ray Computed/methods
16.
Article in Korean | WPRIM | ID: wpr-93355

ABSTRACT

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy. To date, 51 cases have been reported, including 3 in pregnant women. Herein, we report magnetic resonance findings of a 31-year-old Korean woman (15 weeks and 3 days pregnant) with primary retroperitoneal mucinous cystadenocarcinoma. On abdominal magnetic resonance imaging (MRI), a mass was identified in the retroperitoneal area with a nodular lesion showing heterogeneous signal intensity and focal wall thickening on T1- and T2-weighted images. Exploratory laparotomy and tumor excision were performed. Histological examination revealed primary retroperitoneal mucinous cystadenocarcinoma. The patient subsequently underwent total hysterectomy, bilateral salpingo-oophorectomy, and omentectomy for metastatic mucinous cystadenocarcinoma of both ovaries 15 months after her initial surgery.


Subject(s)
Adult , Cystadenocarcinoma, Mucinous , Female , Humans , Hysterectomy , Laparotomy , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Mucins , Ovary , Pregnant Women , Retroperitoneal Neoplasms
17.
Biomedica. 2012; 28: 98-102
in English | IMEMR | ID: emr-144553

ABSTRACT

Ovarian tumours are one of the major causes of gynaecological problems in females and present marked variation in their histological types. Relative frequency of these lesions is different for Western and Asian countries. This study was designed to find out frequency of various histological patterns of ovarian tumors in patients attending Pathology Department of a teaching institute in Lahore. A retrospective case - series study was conducted on 212 cases of ovarian masses, reported from January 2007 to December 2010. Mean age of the subjects was 35.6 years, ranging from 4 to 80 years. In a total of 212 cases of ovarian masses, 85 [40.09%] were non-neoplastic and 127 [59.91%] were neoplastic. Among neoplastic lesions, 64.57% [82/127] were benign and 35.43% [45/127] were malignant. The commonest non-neoplastic lesion was luteal cyst [38/85] followed by simple serous cyst [30/85]. The commonest benign tumour was dermoid cyst [31/82] followed by serous cystadenoms [20/82]. The commonest malignant tumour was serous cystadenocarcinoma [11/45] followed by mucinous cystadenocarcinomama [9/45]. Neoplastic lesions were more common than non-neoplastic lesions, while benign tumours outnumbered the malignant ones. The commonest benign tumour was dermoid cyst and malignant was serous cystadenocarcinoma. The commonest non-neoplastic lesion was luteal cyst. Among histological types of ovarian tumours, surface epithelial tumours dominated the other types


Subject(s)
Humans , Female , Ovarian Cysts , Retrospective Studies , Cystadenoma, Serous , Dermoid Cyst , Cystadenocarcinoma, Serous , Cystadenocarcinoma, Mucinous
18.
Chinese Journal of Pathology ; (12): 23-27, 2012.
Article in Chinese | WPRIM | ID: wpr-242004

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression and significance of neurogenic differentiation protein (NeuroD) in pancreatic carcinoma.</p><p><b>METHODS</b>The expression of NeuroD, PCNA and p53 proteins in 127 specimens of pancreatic carcinoma was detected by tissue microarray and immunohistochemestry. The correlations were analyzed between NeuroD and PCNA, p53, neural invasion, sleeve-like lymphocytic infiltration around the nerve, pancreatitis adjacent to carcinoma, lymph node metastasis and age, gender, location of tumors, histological types and differentiation of pancreatic carcinomas.</p><p><b>RESULTS</b>The positive rates of NeuroD, PCNA and p53 expression were higher in pancreatic carcinoma than those in non-tumor pancreatic tissues [64.6% (82/127) vs 10.5% (8/76), 57.5% (73/127) vs 9.2% (7/76), 59.1% (75/127) vs 9.2% (7/76), P < 0.01]. NeuroD expression in pancreatic carcinoma was related to that of PCNA and p53 and neural invasion (P < 0.05). No significant correlation was found between NeuroD and age, gender, tumor location, histological types and differentiation, sleeve-like lymphocytic infiltration, pancreatitis adjacent to the carcinoma and lymph node metastasis in pancreatic carcinomas.</p><p><b>CONCLUSIONS</b>NeuroD overexpression in pancreatic carcinoma. The overexpression of NeuroD may contribute to the tumorogenesis and development of pancreatic carcinoma, and is closely correlated to the cancer cell proliferation, p53 signal pathway and neural invasion in pancreatic carcinoma.</p>


Subject(s)
Adenocarcinoma , Metabolism , Pathology , Adolescent , Adult , Aged , Aged, 80 and over , Basic Helix-Loop-Helix Transcription Factors , Metabolism , Carcinoma, Adenosquamous , Metabolism , Pathology , Cystadenocarcinoma, Mucinous , Metabolism , Pathology , Cystadenoma, Mucinous , Metabolism , Pathology , Female , Humans , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Invasiveness , Pancreatic Neoplasms , Metabolism , Pathology , Proliferating Cell Nuclear Antigen , Metabolism , Signal Transduction , Tumor Suppressor Protein p53 , Metabolism , Young Adult
19.
Chinese Journal of Pathology ; (12): 33-38, 2012.
Article in Chinese | WPRIM | ID: wpr-242002

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression and promoter methylation status of p73 gene in ovarian epithelial tumors and their clinicopathological correlations.</p><p><b>METHODS</b>Tissue microarrays (TMA) consisting of 68 ovarian cancers, 37 ovarian borderline tumors and 21 ovarian benign tumors were constructed. p73 expression was detected by immunohistochemistry (EnVision method). Fresh-frozen tissue samples from 13 cases of ovarian carcinomas and 5 cases of borderline tumors were evaluated for the presence of p73 promoter methylation using bisulfite sequencing.</p><p><b>RESULTS</b>Overall, 92.6% (63/68) ovarian carcinomas expressed p73, with a mean value of 32% (percentage of p73 positive cells in the tumor). The mean value of p73 expression rate (40%) in serous carcinoma (26/26) was higher than those of other cancer types (P = 0.006). The mean value of p73 expression rate (40%) in type II ovarian carcinoma was significantly higher than that in type I ovarian carcinoma (24%, P = 0.010). The expression of p73 was not associated with FIGO stage and histological grade (both P > 0.05). The mean values of p73 expression in ovarian borderline tumor (30/37) and benign tumor (12/21) were 16% and 15%, respectively. Of the two groups, the mean value of p73 expression rate in serous type was higher than that in mucous type (P = 0.003, P = 0.026). Ovarian carcinomas had a higher level of p73 expression than borderline tumors and benign tumors (both P < 0.05), while that between ovarian borderline tumors and benign tumors had no statistical difference (P > 0.05). Among serous tumors (49/53), the mean value of p73 expression in the carcinoma group (26/26) was significantly higher than those in the borderline tumor group (12/14) and benign tumor group (11/13; P = 0.024 and P = 0.002, respectively), while that between borderline tumor group and benign tumor group had no statistical difference (P = 0.428). Among mucous tumors (15/27), the mean value of p73 expression in carcinoma group (6/7) was higher than that in benign tumor group (1/8; P = 0.032). No statistical difference of p73 expression was seen between the carcinoma group and ovarian borderline tumor group (8/12) and between the borderline tumor group and benign tumor group (P = 0.234, P = 0.201, respectively). p73 promotor methylation was found in 8 of 13 cases of carcinomas but at different methylation levels with a mean value of 8.0%. Two of 5 ovarian borderline tumors showed detectable p73 promotor methylation with a mean value of 9.0%. Compared with the borderline tumors, ovarian carcinomas showed a similar p73 methylation level (P > 0.05). The p73 methylation level in ovarian carcinomas was not associated with histological type, pathogenetic type, histological grade and FIGO stage (all P > 0.05).</p><p><b>CONCLUSIONS</b>Most of ovarian epithelial tumors express p73 protein with mean values higher in ovarian carcinomas than those in the borderline and benign tumors. Ovarian serous carcinomas have the highest expression level of p73. A simple linear correlation does not exist between the promoter methylation and protein expression of p73.</p>


Subject(s)
Adult , Aged , Cystadenocarcinoma, Mucinous , Metabolism , Pathology , Cystadenocarcinoma, Serous , Metabolism , Pathology , Cystadenofibroma , Metabolism , Pathology , Cystadenoma, Mucinous , Metabolism , Pathology , Cystadenoma, Serous , Metabolism , Pathology , DNA Methylation , DNA-Binding Proteins , Metabolism , Female , Gene Expression Regulation, Neoplastic , Humans , Immunohistochemistry , Middle Aged , Neoplasm Grading , Neoplasm Staging , Neoplasms, Glandular and Epithelial , Metabolism , Pathology , Nuclear Proteins , Metabolism , Oligonucleotide Array Sequence Analysis , Ovarian Neoplasms , Metabolism , Pathology , Promoter Regions, Genetic , Tumor Protein p73 , Tumor Suppressor Proteins , Metabolism , Young Adult
20.
Chinese Journal of Pathology ; (12): 86-90, 2012.
Article in Chinese | WPRIM | ID: wpr-241988

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expressions of phosphorylated protein kinase B (p-AKT), phosphorylated glycogen synthase kinase 3β (p-GSK3β) and β-catenin proteins and to evaluate their relationship with the clinical pathological characteristics in epithelial tumors of the ovary.</p><p><b>METHODS</b>The expression of p-AKT, p-GSK3β, and β-catenin was detected with immunohistochemical staining (EnVision method) in 10 cases of benign epithelial neoplasia, 10 cases of borderline epithelial neoplasia and 70 cases of ovarian carcinoma. The relationship of the expression of p-AKT, p-GSK3β and β-catenin with the clinical pathological features was analyzed.</p><p><b>RESULTS</b>The positive expression rates of p-AKT, p-GSK3β and β-catenin in epithelial ovarian carcinoma were 67.1% (47/70), 60.0% (42/70) and 71.4% (50/70), respectively. Compared to the results of benign and borderline epithelial neoplasia, the expression of the three proteins in carcinoma of the ovary was significantly different (all P < 0.05).Positive correlation was found between p-AKT and p-GSK3β, p-GSK3β and β-catenin, and p-AKT and β-catenin in epithelial ovarian carcinoma (r = 0.546, 0.581, 0.500, respectively; all P < 0.05). Compared to the results of benign and borderline epithelial neoplasia, the expression of p-AKT protein in epithelial ovarian carcinoma was significantly different (all P < 0.05). The expression of p-AKT was correlated with the differentiation of epithelial ovarian carcinoma (P < 0.05), but no relationship was found between its expression and histological classification and FIGO staging (P > 0.05). The expression of p-GSK3β and β-catenin in epithelial ovarian carcinoma were both higher than that in benign and borderline epithelial neoplasia (P < 0.05), and correlated with tumor differentiation and FIGO staging (P < 0.05), but no relationship were found between their expression with histological classification (P > 0.05).</p><p><b>CONCLUSIONS</b>Positive correlations are found between p-AKT, p-GSK3β and β-catenin in epithelial ovarian carcinoma. The activation of β-catenin is possibly correlated with inactivation of p-GSK3β that binds to p-AKT.</p>


Subject(s)
Adult , Aged , Carcinoma, Endometrioid , Metabolism , Pathology , Cell Differentiation , Cystadenocarcinoma, Mucinous , Metabolism , Pathology , Cystadenocarcinoma, Serous , Metabolism , Pathology , Cystadenoma, Mucinous , Metabolism , Pathology , Cystadenoma, Serous , Metabolism , Pathology , Female , Glycogen Synthase Kinase 3 , Metabolism , Glycogen Synthase Kinase 3 beta , Humans , Middle Aged , Neoplasm Staging , Ovarian Neoplasms , Metabolism , Pathology , Phosphorylation , Proto-Oncogene Proteins c-akt , Metabolism , beta Catenin , Metabolism
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