Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 582
Filter
1.
Rev. inf. cient ; 100(3): e3455, 2021. tab
Article in Spanish | LILACS | ID: biblio-1289633

ABSTRACT

RESUMEN Introducción: La cirrosis hepática es una de las enfermedades más frecuentes en nuestro país, y la presencia de infecciones y su descompensación constituyen motivos de ingreso hospitalario en estos pacientes. Objetivo: Identificar las enfermedades asociadas al cuidado sanitario más frecuentes en pacientes cirróticos ingresados. Método: Se realizó un estudio de cohorte en 90 pacientes con diagnóstico de cirrosis hepática, ingresados en el Hospital General Provincial "Carlos Manuel de Céspedes" de provincia Granma, en el período comprendido desde enero de 2017 hasta septiembre de 2020. La población estuvo conformada por la totalidad de pacientes mayores de 18 años y de ambos sexos. Los datos se recogieron de las historias clínicas hospitalarias. En el análisis estadístico se empleó el estadígrafo Chi-cuadrado obtenido a partir de tablas de contingencia, y para medir la fuerza de la misma los riesgos relativos (RR), se utilizó un nivel de significación (valor p) menor de 0,05. Resultados: La mayoría de los pacientes fueron del sexo masculino, descompensados con Child-Pugh (B), el alcohol como la etiología más frecuente de la cirrosis, a los que se les realizaron cuidados sanitarios como la colocación de sonda vesical, abordaje venoso central y periférico, así como intubación endotraqueal. Las principales infecciones asociadas al cuidado sanitario observadas en estos pacientes fueron la flebitis, bacteriemia, la infección del tracto urinario y la neumonía. Conclusiones: Las infecciones asociadas al cuidado sanitario según orden de frecuencia fueron la flebitis, la bacteriemia, la pielonefritis, neumonía y cistitis.


ABSTRACT Introduction: Liver cirrhosis has been confirmed as one of the most common diseases in Cuba. Infection and decompensated cirrhosis constitute the cause of hospitalization. Objective: To identify the most frequent health care-associated diseases in hospitalized cirrhotic patients. Method: A cohort study involving 90 hospitalized patients with cirrhosis was conducted at the Hospital General Provincial "Carlos Manuel de Céspedes" in Granma, from January 2017 through September 2020. The total patients underwent study were over 18 years old and both sex. Data were collected from patients´ hospitalization history. Chi-square test was utilized for statistical analysis and to measure its power (the relative risk), a P-value less than 0.05 was used. Results: Most patients were male, decompensated with Child-Pugh class B. All hospitalized patients who underwent health care such as bladder catheter placement, central and peripheral venous approach, as well as endotracheal intubation, alcohol was considered the major etiological factor cause of cirrhosis. The main healthcare-associated infections observed in these patients were phlebitis, bacteremia, urinary tract infection and pneumonia. Conclusions: The healthcare-associated infections in order of frequency were phlebitis, bacteremia, pyelonephritis, pneumonia and cystitis.


RESUMO Introdução: A cirrose hepática é uma das doenças mais frequentes em nosso país, e a presença de infecções e sua descompensação constituem motivos de internação nesses pacientes. Objetivo: Identificar as doenças associadas aos cuidados de saúde mais frequentes em pacientes cirróticos hospitalizados. Método: Foi realizado um estudo de coorte em 90 pacientes com diagnóstico de cirrose hepática, internados no Hospital Geral Provincial "Carlos Manuel de Céspedes" da província de Granma, no período de janeiro de 2017 a setembro de 2020. A população foi constituída por para todos os pacientes com mais de 18 anos de idade e de ambos os sexos. Os dados foram coletados em prontuários hospitalares. Na análise estatística, foi utilizada a estatística Qui-quadrado obtida em tabelas de contingência e, para medir a força dos riscos relativos (RR), foi utilizado um nível de significância (p-valor) menor que 0,05. Resultados: A maioria dos pacientes era do sexo masculino, descompensados com Child-Pugh (B), sendo o álcool a etiologia mais frequente da cirrose, que realizaram cuidados de saúde como colocação de cateter vesical, abordagem venosa central e periférica, além de intubação endotraqueal. As principais infecções associadas aos cuidados de saúde observadas nestes pacientes foram flebite, bacteremia, infecção do trato urinário e pneumonia. Conclusões: As infecções associadas aos cuidados de saúde em ordem de frequência foram flebite, bacteremia, pielonefrite, pneumonia e cistite.


Subject(s)
Humans , Male , Female , Middle Aged , Heart Disease Risk Factors , Infections , Liver Cirrhosis/complications , Phlebitis , Pneumonia , Pyelonephritis , Prospective Studies , Bacteremia , Cystitis , Ethanol
3.
Int. braz. j. urol ; 47(2): 295-305, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1154442

ABSTRACT

ABSTRACT The standard treatment for locally advanced cervical cancer (CC) is chemoradiotherapy. Once the bladder receives part of the radiation, a typical inflammatory condition that configures radiation-induced cystitis may develop. Chronic radiation-induced cystitis is commonly characterized by the bladder new submucosal vascularization, which is typically fragile and favors hematuria. The current study aims to investigate if Hypoxia-Induced Factor (HIF-1α) and its transcriptional target Vascular Endothelial Growth Factor A (VEGF-A) could be a primary pathway leading to increased submucosal vascularization. HIF-1α and VEGF-A mRNA levels in bladder core biopsies from CC patients treated with radiotherapy versus untreated (non-irradiated) patients were analyzed using a droplet digital polymerase chain reaction technology. Gene expression results showed that HIF-1α and VEGF-A had no significant differences between bladder samples from patients previously irradiated and untreated patient samples. However, a direct relationship between the degree of late morbidity and the expression of HIF-1α and VEGF-A has been demonstrated. Despite the lack of statistical significance precludes a definitive conclusion, the data presented herein suggests that further studies investigating the role of HIF-1α in bladder neovascularization in radiation-induced cystitis are highly recommended.


Subject(s)
Humans , Female , Uterine Cervical Neoplasms , Cystitis/etiology , Case-Control Studies , Vascular Endothelial Growth Factor A , Hypoxia-Inducible Factor 1, alpha Subunit/genetics , Neovascularization, Pathologic
4.
Article in Chinese | WPRIM | ID: wpr-880121

ABSTRACT

OBJECTIVE@#To analyze the risk factors affecting hemorrhagic cystitis(HC) after allogeneic hematopoietic stem cell transplantation(allo-HSCT).@*METHODS@#The clinical data of 153 patients underwent allogeneic hematopoietic stem cell transplantation in the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2018 were selected and retrospectively analyzed. The incidence, median time and treatment outcome of HC should be observed. Multivariate analysis was used to observe the risk factors of HC in patients, including sex, age, diagnosis, disease status before transplantation, transplantation type, ATG and CTX in the pretreatment scheme, stem cell source, neutrophil and platelet implantation time; CMV, EBV and BKV infection, and acute graft-versus-host disease(aGVHD).@*RESULTS@#Among 153 patients underwent allogeneic hematopoietic stem cell transplantation, 25 (16.34%) patients had HC, the median occurance time was 31 days, all patients achieved complete remission after treatment, no bladder irritation and bladder contracture were left. The results of univariate and multivariate Logistic regression analysis showed that the type of transplantation, ATG, CMV viremia before treatment, aGVHD (r=1.036, 3.234, 3.298 and 2.817, respectively) were the independent risk factors of HC.@*CONCLUSION@#The urinary BKV detections in the patients with HC are positive, mainly occured during the period from day +13 to days +56. HLA haplotype, pretreatment including ATG, and CMV viremia, and aGVHD are the independent risk factors for HC after allo-HSCT.


Subject(s)
Cystitis/etiology , Graft vs Host Disease , Hematopoietic Stem Cell Transplantation/adverse effects , Humans , Retrospective Studies , Risk Factors
5.
Rev. colomb. nefrol. (En línea) ; 7(1): 143-148, ene.-jun. 2020. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1144382

ABSTRACT

Resumen La cistitis enfisematosa hace referencia a una entidad infrecuente, generalmente secundaria a infecciones de vías urinarias bajas, que por diferentes mecanismos producen gas alrededor de la vejiga. Esta patología se asocia a gérmenes (E. Coli, Enterobacter Arogenes, y Klebsiella, entre otros), y factores de riesgo como género femenino, edad avanzada y diabetes. Este diagnóstico requiere un manejo oportuno, con antibioticoterapia dirigida y control de comorbilidades asociadas; a continuación, se reporta el caso de un paciente masculino de 81 años, en el hospital de San José de Bogotá, a quien se le diagnostica esta patología, con el respectivo aislamiento microbiológico, factores de riesgo, diagnóstico y manejo instaurado.


Abstract The emphysematous cystitis refers to an uncommon entity generally secondary to low urinary tract infections producing gas around the bladder. It is associated with infections by E. Coli, Enterobacter Arogenes, and Klebsiella as well as patient risk factors such as advanced age, diabetics and female gender. The diagnosis requires a timely management as well as directed antibiotic and associated comorbidities control. In the following case report a male patient is described in the hospital of San José de Bogotá in whom this pathology is diagnosed. In the following case report we going to describe etiologies diagnosis and therapy.


Subject(s)
Humans , Male , Aged, 80 and over , Cystitis , Patients , Urinary Tract Infections , Case Reports , Risk Factors , Colombia , Diabetes Mellitus, Type 2
6.
Arq. bras. med. vet. zootec. (Online) ; 72(3): 931-935, May-June, 2020. tab, graf
Article in English | ID: biblio-1129612

ABSTRACT

Bacterial resistance is a reality in both human and veterinary health, it limits the therapeutic arsenal and raises the costs of the patient's treatment. A dog with signs of cystitis received treatment with 5mg/kg enrofloxacin at three consecutive times, with low effectiveness. The presence of urethral uroliths was identified and urohydropulsion was done. The animal presented a new obstruction, for which a cystotomy was performed, but continued with signs of infection. Uroculture and antimicrobial susceptibility test were then performed. Escherichia coli was identified, which was resistant to 13 antibiotics, being sensitive only to piperacillin-tazobactam and amikacin. In the screening test for ß-lactamase, the production of ESßL was detected. The qPCR indicated the presence of the bla CTXm, bla DHA, bla OXA, bla IMP, bla TEM, bla GIM, bla SIM, bla SPM and bla SME genes, which may lead to a phenotypic resistance profile for ampicillin, amoxicillin-clavulanate, aztreonam, cefepime cefoxitin, cefuroxime, ceftazidime, ceftriaxone, imipenem, and piperacillin-tazobactam. This case reaffirms the value that laboratory analysis adds to the diagnosis and treatment of cystitis and urolithiasis, which can define the direction of evolution of the prognosis and the speed at which the patient's health will be restored.(AU)


A resistência bacteriana aos antibióticos é uma realidade, tanto na saúde humana quanto veterinária, limita o arsenal terapêutico e eleva os custos relacionados ao tratamento do paciente. Um cão, com sinais de cistite, recebeu tratamento com enrofloxacina, na dose de 5mg/kg, em três momentos seguidos, com baixa efetividade. Identificou-se presença de urólitos uretrais e foi feita uro-hidropropulsão. O animal apresentou nova obstrução, para a qual foi realizada uma cistotomia, mas continuou com sinais de infecção. Realizou-se, então, urocultura e teste de antibiograma. Foi identificada Escherichia coli, que se mostrou resistente a 13 antibióticos, sendo sensível somente à piperacilina-tazobactam e amicacina. No teste de triagem para ß-lactamase, detectou-se a produção de ESßL. A qPCR indicou presença dos genes blaCTXm, blaDHA, blaOXA, blaIMP, blaTEM, blaGIM, blaSIM, blaSPM e blaSME, que podem conduzir um perfil fenotípico de resistência para ampicilina, amoxicilina-ácido clavulânico, aztreonam, cefepima, cefoxitina, cefuroxima, ceftazidima, ceftriaxona, imipenem, piperacilina-tazobactam. Este caso reafirma o valor que a análise laboratorial agrega ao diagnóstico e tratamento da cistite e da urolitíase, podendo definir o sentido de evolução do prognóstico e a velocidade em que a saúde do paciente será restabelecia.(AU)


Subject(s)
Animals , Dogs , Cystitis/veterinary , Drug Resistance, Multiple, Bacterial , Escherichia coli/isolation & purification , Urolithiasis , Cystotomy/veterinary , Enrofloxacin
7.
Rev. cuba. hematol. inmunol. hemoter ; 36(1): e1127, ene.-mar. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126548

ABSTRACT

Introducción: Las infecciones por virus o la reactivación de virus en estado latente son frecuentes durante el estado de inmunosupresión que sigue al trasplante de progenitores hematopoyéticos, y constituyen una causa importante de complicaciones, como la cistitis hemorrágica, que se caracteriza por disuria, polaquiuria, dolor abdominal y hematuria. La aparición precoz se asocia a la administración de citostáticos como la ciclofosfamida, y el comienzo tardío a la primoinfección o reactivación de virus como citomegalovirus, los adenovirus o los poliomavirus como el BK y el JC. Objetivo: Describir las características clínicas, la evolución y el manejo de la cistitis hemorrágica postrasplante. Casos clínicos: Se presentan dos pacientes con leucemia mieloide aguda que desarrollaron cistitis hemorrágica asociada a infección viral por virus BK y citomegalovirus después del trasplante haploidéntico con ciclofosfamida postrasplante. La cistitis hemorrágica de causa viral después del trasplante hematopoyético en estos pacientes estuvo asociada a una severa inmunosupresión, por lo que constituyó una complicación potencialmente letal. Los dos pacientes presentaron cistitis hemorrágica grado IV y fallecieron a pesar del tratamiento. Conclusiones: El trasplante haploidéntico con la administración de ciclofosfamida postrasplante incrementa la posibilidad de donantes de progenitores hematopoyéticos para los pacientes sin un hermano HLA idéntico pero el mayor nivel de inmunosupresión podría aumentar la incidencia de cistitis hemorrágica de causa viral(AU)


Introduction: Viral infections or latent-virus reactivation are frequent during the immunosuppressed cincition that follows hematopoietic stem-cell transplantation, and an important cause of complications, such as hemorrhagic cystitis, characterized by dysuria, urinary frequency, abdominal pain, and hematuria. The early appearance is associated with the administration of cytostatic drugs such as cyclophosphamide, and the late onset is associated with primary infection or reactivation of viruses such as cytomegalovirus, adenoviruses, or polyomaviruses such as BK and JC. Objective: To describe the clinical characteristics, evolution and management of post-transplant hemorrhagic cystitis. Clinical cases: The cases are presented of two patients with acute myeloid leukemia who developed hemorrhagic cystitis associated with viral infection by BK virus and cytomegalovirus after haploidentical transplantation with post-transplant cyclophosphamide. Viral hemorrhagic cystitis after hematopoietic transplantation in these patients was associated with severe immunosuppression, making it a potentially lethal complication. Both patients presented grade IV hemorrhagic cystitis and died despite treatment. Conclusions: Haploidentical transplantation with the of post-transplant cyclophosphamide administration increases the possibility for donors of hematopoietic progenitor cells to patients without an identical HLA match, but the higher level of immunosuppression could increase the incidence of viral hemorrhagic cystitis(AU)


Subject(s)
Humans , Male , Adolescent , Adult , Cytomegalovirus Infections/complications , Hematopoietic Stem Cell Transplantation/adverse effects , Cystitis/mortality , Cystitis/blood , Virus Diseases/complications , Cyclophosphamide/adverse effects
8.
Rev. bras. cancerol ; 66(1)20200129.
Article in Portuguese | LILACS | ID: biblio-1094947

ABSTRACT

Introdução: O câncer de próstata é considerado a neoplasia maligna mais comum que acomete homens em todas as Regiões do país, à exceção do câncer de pele não melanoma. Se diagnosticado e tratado precocemente, o câncer de próstata tem alta taxa de cura; contudo, terapêuticas como a radioterapia podem gerar complicações agudas que podem impactar as atividades cotidianas. Apesar das complicações no pós-tratamento, a radioterapia tem sido um método bastante praticado e que apresenta resultados positivos, ocasionando melhoria da sobrevida livre de doença. Objetivo: Avaliar os principais fatores preditores de complicações agudas que acometem pacientes em tratamento radioterápico para câncer de próstata. Método: Para identificação de fatores preditores de complicações agudas pós-radioterapia, avaliaram-se, consecutiva e prospectivamente, 208 pacientes diagnosticados com adenocarcinoma de próstata tratados com radioterapia conformacional 3D em um centro referência vinculado ao SUS entre os anos 2016 e 2017. Realizou-se ainda avaliação retrospectiva de prontuários para coleta de dados adicionais. A análise estatística foi realizada por meio dos testes qui-quadrado, exato de Fisher, Anova e regressão logística ordinal. Resultados: Após análise da amostra, evidenciou-se que, entre as complicações agudas, as de maior incidência foram radiodermite, cistite e enterite/retite, de forma que tais complicações tiveram como fatores associados volume irradiado, tratamento prévio e sintomas prévios ao tratamento. Conclusão: O estudo sugere que, apesar da existência de complicações ao final do tratamento, a grande maioria é de baixa complexidade e que pacientes submetidos a procedimentos cirúrgicos prévios podem evoluir com presença de complicações mais graves.


Introduction: Prostate cancer is considered the most common malignancy that affects men in all regions of the country, except for non-melanoma skin cancer. If diagnosed and treated early, prostate cancer has a high cure rate; however, therapies such as radiotherapy can generate acute complications that can impact daily activities. Despite post-treatment complications, radiotherapy has been a widely practiced method and has shown positive results, leading to improved disease-free survival. Objective: To evaluate the main predictive factors for acute complications that affect patients undergoing radiotherapy for prostate cancer. Method: To identify predictive factors for acute post-radiotherapy complications, 208 patients diagnosed with prostate adenocarcinoma treated with 3D conformational radiotherapy were consecutively and prospectively evaluated at a referral center linked to SUS between the years 2016 and 2017. It was carried out retrospective evaluation of medical records to collect additional data. Statistical analysis was performed using the chi-square test, Fisher's exact, Anova and ordinal logistic regression. Results: After analyzing the sample, it was evidenced that among the acute complications, those with the highest incidence were radiodermatitis, cystitis, enteritis/rectitis, so that these complications had associated predictive factors as irradiated volume, previous treatment and symptoms. Conclusion: The study suggests that despite the existence of complications at the end of the treatment, the vast majority are of low complexity and that the patients submitted to previous surgical procedures can evolve with the presence of more severe complications.


Introducción: El cáncer de próstata se considera la neoplasia maligna más común que afecta a los hombres en todas las regiones del país, con la excepción del cáncer de piel no melanoma. Si se diagnostica y trata temprano, el cáncer de próstata tiene una alta tasa de curación; sin embargo, las terapias como la radioterapia pueden generar complicaciones agudas que pueden afectar las actividades diarias. A pesar de las complicaciones posteriores al tratamiento, la radioterapia ha sido un método ampliamente practicado y ha mostrado resultados positivos, lo que lleva a una mejor supervivencia libre de enfermedad. Objetivo: Evaluar los principales predictores de complicaciones agudas que afectan a los pacientes sometidos a radioterapia para el cáncer de próstata. Método: Para identificar los factores predictivos de complicaciones agudas posteriores a la radioterapia, 208 pacientes diagnosticados con adenocarcinoma de próstata tratados con radioterapia conformacional 3D fueron evaluados consecutiva y prospectivamente en un centro de referencia vinculado al SUS entre los años 2016 y 2017. Se realizó evaluación retrospectiva de registros médicos para recopilar datos adicionales. El análisis estadístico se realizó utilizando la prueba de chi-cuadrado, exacta de Fisher, de Anova y la regresión logística ordinal. Resultados: Después de analizar la muestra, se evidenció que, entre las complicaciones agudas, las de mayor incidencia fueron radiodermatitis, cistitis, enteritis/retitis y síntomas obstructivos, por lo que estas complicaciones tenían factores predictivos asociados, como el volumen irradiado, el tratamiento previo y los síntomas. Conclusión: El estudio sugiere que a pesar de la existencia de complicaciones al final del tratamiento, la gran mayoría son de baja complejidad. Como factores predictivos encontrados, se puede mencionar el volumen irradiado, la existencia de tratamiento previo y los síntomas en la consulta inicial.


Subject(s)
Humans , Male , Adult , Middle Aged , Aged , Aged, 80 and over , Prognosis , Prostatic Neoplasms/radiotherapy , Adenocarcinoma/radiotherapy , Radiotherapy, Conformal/adverse effects , Radiodermatitis/radiotherapy , Brazil , Adenocarcinoma/complications , Retrospective Studies , Acute Toxicity , Cystitis/radiotherapy , Enteritis/radiotherapy
9.
Medicina (Ribeiräo Preto) ; 52(3)jul.-set. 2019.
Article in Portuguese | LILACS | ID: biblio-1025786

ABSTRACT

A mucosa vesical, na presença de agentes agressores, sofre alterações inicialmente benignas, mas com a cronicidade pode sofrer modificações potencialmente metaplásicas. A cistite glandular apresenta um quadro sintomático inespecífico, sendo necessária a realização de biópsia para seu diagnóstico e diferenciação histológica, podendo dividir-se em subtipos clássico e intestinal. Após análise de prontuário médico pertencente ao Hospital Santa Rita de Maringá, objetiva-se relatar o caso de um paciente masculino, de 32 anos, com disúria e dor em hipogástrico, apresentando em ultrassonografia lesão cística de 3,8 cm de diâmetro na bexiga. Após a retirada da lesão por ressecção transuretral, a análise histopatológica revelou presença de ninhos de Von Brunn, áreas de epitélio mucossecretor e mucina extracelular na mucosa vesical, propondo a existência de lesão glandular com metaplasia intestinal. Foi realizado estudo imunohistoquímico para diagnóstico diferencial de adenocarcinoma mucossecretor bem diferenciado. A cistite glandular, quando manifestada macroscopicamente, assemelha-se a uma neoplasia por apresentar um aspecto irregular, difuso e algumas vezes ulceroso. Seu diagnóstico e tratamento podem ser simultâneos, porém, nos casos mais graves, as opções terapêuticas são restritas. O diagnóstico diferencial é extremamente importante para afastar a possibilidade de adenocarcinoma vesical, portanto, é imprescindível o acompanhamento periódico dos pacientes após o tratamento com a realização de exames específicos. O uso de marcadores imunohistoquímicos tem se tornado relevante para o correto diagnóstico, pois genes relacionados ao ciclo celular, como o fator de transcrição homebox 2 do tipo caudal (CDX2), podem representar um vínculo entre o surgimento de metaplasia e sua possível progressão a adenocarcinoma. (AU)


The bladder's mucosa, in the presence of aggressive agents, undergoes initially benign changes, but with chronicity may undergo potentially metaplastic modifications. Glandular cystitis presents nonspecific symptoms and biopsy is necessary for diagnosis and histological differentiation, subdividing it into classic and intestinal subtypes. After analyzing a medical record belonging to the Santa Rita Hospital from Maringá, the objective of this study is to report the case of a 32-year-old male patient with dysuria and pain in the hypogastric region, presenting on ultrasonography cystic lesion of 3.8 cm of diameter in the bladder. After removal of the lesion by transurethral resection, the histopathological analysis revealed the presence of Von Brunn nests, areas of mucosecretory epithelium and extracellular mucin in the bladder's mucosa, suggesting the existence of a glandular lesion with intestinal metaplasia. It was performed an immunohistochemical study for differential diagnosis of well-differentiated mucosecretory adenocarcinoma. Glandular cystitis, when manifest-ed macroscopically, resembles a neoplasm, since it can present an irregular aspect, diffuse and sometimes ulcerous. The diagnosis and treatment can be simultaneous, but in severe cases, the therapeutic options are restricted. Differential diagnosis is extremely important to rule out the possibility of bladder adenocarcinoma, therefore it is essential to follow up patients after treatment with specific tests periodically. The use of immunohistochemical markers has become rele-vant for the correct diagnosis, since genes related to the cell cycle, such as caudal type homeobox transcription factor 2 (CDX2), may represent a link between the onset of metaplasia and its possible progression to adenocarcinoma (AU)


Subject(s)
Humans , Male , Adult , Urologic Surgical Procedures, Male , Cystitis , Metaplasia
12.
Infectio ; 23(1): 45-51, Jan.-Mar. 2019. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-975562

ABSTRACT

Resumen Introducción: La infección de vías urinarias (IVU) es una de las enfermedades más prevalentes en la práctica clínica Objetivo: Identificar los principales agentes etiológicos y la frecuencia de resistencia a antibióticos por parte de microorganismos aislados por urocultivos en pa cientes con IVU en un hospital de primer nivel de atención. Materiales y Métodos: Estudio descriptivo de corte transversal, a partir de una muestra aleatoria de pacientes con IVU en La Virginia, Risaralda, entre el 1 de abril de 2014 a 31 de marzo de 2015. Se evaluaron las bacterias aisladas en la totalidad de urocultivos procesados y los resultados de los antibiogramas. Se establecieron frecuencias y proporciones. Para el análisis de datos, se utilizó SPSS Statistics 22. Se hizo análisis multivariado. Resultados: Se realizaron 1563 urocultivos en el periodo de estudio, de los cuales 329 (21,0%) mostraron crecimiento mayor a 100.000 UFC. Las frecuencias más altas de resistencia para E. coli se observaron para cefalotina (75,8%), ampicilina (72,6%) y trimetoprim/sulfametoxazol (55,3%). De 296 pacientes seleccionados aleatoriamente se halló que la cistitis era la IVU más frecuente (70,3%) y al 50,7% no se les prescribió ningún antimicrobiano. El uso de antiulcerosos se asoció con mayor probabilidad de uso inadecuado del antibiótico (OR:4,28; IC95%:1,070-17,153; p=0,04). Conclusiones: Existe una elevada resistencia bacteriana a los antibióticos de primera línea para el tratamiento de las IVUs, lo que sugiere la importancia de identi ficar los microorganismos y sus perfiles de sensibilidad a antimicrobianos para seleccionar con mejor criterio cual emplear.


Abstract Introduction: Urinary tract infection (UTI) is one of the most prevalent diseases in clinical practice. Objective: To identify the main etiologic agents and the frequency of antibiotic resistance by microorganisms isolated from urine culture and sensitivity in patients with IVU in a hospital primary care. Materials and Methods. Descriptive cross-sectional study, from a random sample of patients with UTI in La Virginia, Risaralda, from April 1, 2014 to March 31, 2015. Bacteria isolated from all processed urine cultures and the results of susceptibility were evaluated. Frequencies and proportions were established. For data analysis was used SPSS Statistics 22. Results: A total of 1563 urine cultures were performed in the study period, of which 329 (21.0%) showed further growth to 100,000 UFC. Higher frequencies of resis tance were observed for E. coli to cephalothin (75.8%), ampicillin (72.6%) and trimethoprim/sulfamethoxazole (55.3%). In the 296 randomized patients it was found that the most common UTI was cystitis (70.3%) and 50.7% were not prescribed any antimicrobial. The use of anti-ulcer is associated with increased probability of inappropriate use of antibiotics (OR:4.28; 95% CI:1.070-17.153; p=0.04). Conclusions: There is a high bacterial resistance to first-line antibiotics for treatment of UTIs, suggesting the importance of identifying microorganisms and their antimicrobial susceptibility profiles to select which use better approach.


Subject(s)
Humans , Female , Adult , Middle Aged , Urinary Tract , Urinary Tract Infections , Drug Resistance, Microbial , Cephalosporins , Cystitis , Anti-Bacterial Agents , Sulfamethoxazole , Bacteria , Trimethoprim , Cephalothin , Cross-Sectional Studies , Multivariate Analysis , Selectins , Escherichia coli , Ampicillin , Anti-Infective Agents , Anti-Ulcer Agents
13.
Rev. Soc. Argent. Diabetes ; 53(1): 41-44, Ene.-Abr. 2019.
Article in Spanish | LILACS | ID: biblio-1021906

ABSTRACT

La cistitis bacteriana aguda es un proceso infeccioso de la vejiga. La prescencia de disuria, polaquiuria, tenesmo, dolor hipogástrico y/o hematuria, aumenta la probabilidad diagnóstica. Ante la sospecha clínica debe solicitarse sedimento urinario y evaluar presencia de leucocituria, piuria o microhematuria, y requerir urocultivo previo al inicio del tratamiento. La prostatitis bacteriana aguda es una entidad poco frecuente pero que requiere diagnóstico y tratamiento precoz, con aislamiento del gérmen. La uretritis puede ser de etiología infecciosa o no. En estas patologías, el tratamiento no difiere de los pacientes sin diabetes, pero deben tenerse presente factores como la neuropatía autonómica que puede encubrir la sintomatología y aumentar el riesgo de descompensación metabólica y cetoacidosis


Acute bacterial cystitis is an infectious process of the bladder. The presence of dysuria, pollakiuria, tenesmus, hypogastric pain and/or hematuria increases the diagnostic probability. In view of clinical suspicion, urinary sediment should be requested to evaluate the presence of leukocyturia, pyuria or microhematuria, and urine culture requested before starting treatment. Acute bacterial prostatitis is a less frequent entity but requires early diagnosis and treatment, with germ isolation. Urethritis can be of infectious etiology or not. In these pathologies, treatment does not differ from patients without diabetes, but factors such as autonomic neuropathy that can conceal the symptoms and increase the risk of metabolic decompensation and ketoacidosis should be considered


Subject(s)
Prostatitis , Urethritis , Cystitis
14.
Repert. med. cir ; 28(1): 39-44, 2019. Il., tablas
Article in English, Spanish | LILACS, COLNAL | ID: biblio-1007488

ABSTRACT

Objetivo: determinar la incidencia de los trastornos hipertensivos del embarazo en pacientes con infección del tracto urinario (ITU) en los Hospitales de San José e Infantil Universitario de San José, Bogotá, Colombia, en 2015. Materiales y métodos: cohorte de embarazadas que asistieron a urgencias con ITU que requirieron tratamiento intrahospitalario y seguimiento para establecer la ocurrencia de trastornos hipertensivos. La frecuencia de estos se describe sobre la base de incidencias acumuladas, así como en términos de la incidencia en cada nivel individual de gravedad de la ITU. Resultados: 138 embarazadas cumplieron con los criterios requeridos, edad media de 25 años (RIQ: 21-29), 42% cursaban el primer embarazo. El germen más aislado fue Escherichia coli. La incidencia de trastornos hipertensivos fue 21,7%. El trastorno más frecuente fue la preeclampsia y el tipo de ITU que más se presentó fue bacteriuria asintomática (35.5%). Conclusión: la ocurrencia de trastornos hipertensivos en embarazadas con infección del tracto urinario fue de 21,7%. Es importante investigar las infecciones del tracto urinario durante el embarazo como posibles factores generadores de preeclampsia


Objective: to present the basic mathematical, physical and radiological principles behind tractography, as well as, providing a review of the main tracts in the brain and their applications in neuroscience from the Fundación Universitaria de Ciencias de la Salud (FUCS) in Bogota D.C., Colombia experience. Materials and Methods: bibliographic review and use of a 1.5 T or 3T MR imaging system to describe tractography images in central nervous system disorders. Results: the main features of tractography are shown based on cases at our institution. Discussion: there are no identified studies on the usefulness of tractography in the vast majority of brain related pathologies. Although this procedure is currently available, clinical information is scarce, as the image-processing techniques are lengthy and in most institutions, protocols have not been determined to reconstruct each of the tracts in the brain. Conclusions: it is possible to reconstruct brain tracts using 1.5T and 3T scanners, identifying the major brain tracts and their relationship with brain tumors, cranioencephalic trauma, substance abuse and other conditio


Subject(s)
Humans , Pyelonephritis , Pre-Eclampsia , Proteinuria , Cystitis , Hypertension, Pregnancy-Induced , Eclampsia , Asymptomatic Diseases
15.
Article in Korean | WPRIM | ID: wpr-786326

ABSTRACT

PURPOSE: This study aimed to determine health problems experienced by workers in special employment relationships (WSER) and identify coping strategies used when such problems occur.METHODS: This qualitative study used the focus group interview method. Thirteen study participants included five home-visit tutors, five insurance salespersons, and three credit card recruiters. The interviews were conducted from November 2018 through January 2019, with each occupational group interview lasting about 2 hours. Analysis based on phenomenological research was independently performed by two researchers.RESULTS: Most participants had common health problems involving vocal cord symptoms, and stress related to emotional labor and traffic accidents. The unique health problems included cystitis, musculoskeletal, and digestive symptoms in home-visit tutors; reduced vision and hearing in insurance salespersons; and mental distress in credit card recruiters. There was no protection system for their health coverage, and the company emphasized their self-employed status to avoid taking responsibility for them. Twelve participants did not purchase occupational accident insurance owing to both not having adequate information and economic burden concerning premium status.CONCLUSION: WSER experienced both physical and mental health problems. These problems were caused by their unstable employment status, and the social security system for their coverage being non-functioning.


Subject(s)
Accidents, Occupational , Accidents, Traffic , Cystitis , Employment , Focus Groups , Hearing , Humans , Insurance , Mental Health , Methods , Occupational Groups , Occupational Health , Qualitative Research , Social Security , Vision, Low , Vocal Cords
16.
Article in Chinese | WPRIM | ID: wpr-771852

ABSTRACT

OBJECTIVE@#To analyze the incidence of hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation and the factors affecting HC, so as to provide clinical evidence for further treatment of HC.@*METHODS@#The HC of 113 patients after allogeneic hematopoietic stem cell transplantation in Affiliated Hospital of Xuzhou Medical University between the years 2014-2016 was analyzed respectively. All cases of HC were divided into HC group and non-HC(control) group. The follow-up time: from preeonditionig day to 180 d after transplantation. The 10 clinical parameters were selected for univariate analysis with COX regression analysis: sex, age (<25 years and 25 years), primary disease, conditioning regimen with anti-thymoglobulin(ATG), sex-mismatch in recipients, haploidential HSCT, cytomegalovirus (CMV) viremia, EB viremia, graft-versus-host disease (GVHD), and primary disease relapse, the factors significant at the 0.1 level in univariate analysis should be further evaluated by multivariate analysis using a COX regression analysis. The difference was significant at P<0.05 in multivariate analysis.@*RESULTS@#The HC occured in 31 of 113 patients (27.4%), with 5 cases of grade I (5.5%), 19 of grade II (16.8%), 5 of grade III (4.4%), and 2 of grade IV (1.8%). The median time of HC onset was 37 days (26-70 d) after transplantation. The median duration of HC was 14 days (5-55d). Univariate analysis showed that conditioning with anti-thymoglobulin (ATG) (RR=6.170, 95%CI: 1.875-20.306, P<0.01), CMV viremia (RR=7.633, 95%CI:2.318-25.133) (P<0.01), haploidentical HSCT (RR=0.307, 95%CI:0.137-0.686, P<0.01), GVHD (RR=1.891, 95%CI:0.918-3.898, P>0.05) were the risk factors for recovery from HC. The multivatiate analysis of above-mentioned risk factors with statistical significance showed that only CMV viremia (RR=4.770, 95%CI: 1.394-16.326, P<0.05) was the indentified risk factor affecting the recovery from HC.@*CONCLUSION@#Monitoring CMV viremia and antivirotic treatment are effective measurs to prevent the occurrence of HC and promote the recovery from HC.


Subject(s)
Cystitis , Graft vs Host Disease , Hematopoietic Stem Cell Transplantation , Humans , Multivariate Analysis , Retrospective Studies , Risk Factors
17.
Int. braz. j. urol ; 44(6): 1252-1255, Nov.-Dec. 2018. graf
Article in English | LILACS | ID: biblio-975670

ABSTRACT

ABSTRACT Encrusted cystitis (EC) was first described as chronic cystitis with mucosal calcification in 1914 (1). It is a very rare chronic inflammatory disease presenting with dysuria, pelvic pain and gross hematuria. Voided urine contains mucus or calcified mucopurulent stone like particles. Urinalysis always reveals alkaline pH. It may be present in healthy individuals with no predisposing etiological factors (2-4). Etiologically, previous urological diseases, immunosuppression, urinary infection with urea splitting bacteria, or urological interventions resulting in bladder mucosa trauma may also be present (5, 6). In the present case report, we describe a novel treatment for EC with intravesical dimethyl sulfoxide.


Subject(s)
Humans , Male , Adult , Dimethyl Sulfoxide/therapeutic use , Corynebacterium/classification , Corynebacterium Infections/drug therapy , Cystitis/drug therapy , Administration, Intravesical , Chronic Disease , Treatment Outcome , Corynebacterium/isolation & purification , Corynebacterium Infections/diagnosis , Corynebacterium Infections/microbiology , Cystitis/diagnosis , Cystitis/microbiology
18.
Rev. ciênc. méd., (Campinas) ; 27(3): http://dx.doi.org/10.24220/2318-0897v27n3a4115, set.-dez. 2018. tab, ilus
Article in Portuguese | LILACS | ID: biblio-981285

ABSTRACT

Objetivo Esta pesquisa teve por objetivo determinar a prevalência de fatores associados às infecções do trato urinário e genital em mulheres em período gestacional. Métodos Trata-se de pesquisa epidemiológica de caráter descritivo com abordagem quantitativa, realizada por meio da coleta de dados em prontuários de gestantes atendidas em nove Unidades Básicas de Saúde distribuídas em Cascavel, Paraná, entre janeiro e dezembro de 2015. Foram consideradas as gestantes com diagnóstico positivo para qualquer doença que acometa os tratos genital e urinário. Foram coletadas dos prontuários informações sociodemográficas, comportamentais, clínicas e resultados laboratoriais. Para as análises estatísticas foi utilizado o método de Qui-Quadrado. Resultados Foram analisados 798 prontuários, observando-se uma positividade de 33,08% (264 casos) com infecções do trato urinário, genital ou ambos. Destas pacientes, 125 (15,66%) apresentaram episódios de infecções do trato urinário, 115 (14,41%) foram acometidas por algum tipo de infecção genital e 24 (3,01%) estavam coinfectadas. Verificou-se diferença estatística em relação ao número de pacientes que apresentaram sinais e sintomas característicos para infecções do trato urinário (<0,001), infecção genital (<0,001) e para casos anteriores de infecções do trato urinário (<0,001). A maioria das infecções do trato genital deu-se por Gardnerella vaginalis (43/37,39%) e Candida sp. (34/29,57%). Conclusão Os resultados indicam altas prevalências de infecções do trato urinário e infecção genital, considerando que, em gestantes, as consequências para o bebê podem ser graves, o que torna o diagnóstico dessas doenças de suma importância na determinação de medidas preventivas. Sendo assim, a investigação, o diagnóstico precoce e o tratamento adequado auxiliam no controle de infecções e problemas congênitos.


Objective To determine the prevalence of factors associated with urinary tract infections, infections of the genital tract in gestational women. Methods A descriptive epidemiological research with a quantitative approach was carried out by means of the collection of data in records of pregnant women attended at nine Basic Health Units distributed in Cascavel, Paraná, between January and December 2015. Pregnant women were considered with positive diagnosis for any disease that affects the genital and urinary tracts. Sociodemographic, behavioral, clinical and laboratory results were collected from the medical records. Statistical analyses were performed using the Chi-square method. Results A total of 798 records were analyzed, with a positive (urinary tract infections or genital infection or urinary tract infections and genital infection) of 33.08% (264 cases). Of these, 125 (15.66%) presented urinary tract infections episodes, 115 (14.41%) were affected by some type of genital infection and 24 (3.01%) were co-infected. There was a statistically significant difference in the number of patients presenting characteristic signs and symptoms for urinary tract infections (<0.001), genital infection (<0.001) and previous cases of urinary tract infections (<0.001). The majority of infections of the genital tract were Gardnerella vaginalis (43/37.39%) and Candida sp. (34/29.57%). Conclusion The prevalence of urinary tract infections and genital infection has been high considering that in pregnant women the consequences for the baby may be serious, which makes the diagnosis of these diseases of paramount importance in determining preventive measures. Therefore, research, early diagnosis and appropriate treatment help control infections and congenital problems.


Subject(s)
Sexually Transmitted Diseases, Bacterial/epidemiology , Cystitis , Pregnant Women
19.
SELECTION OF CITATIONS
SEARCH DETAIL