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1.
Rev. bras. oftalmol ; 80(4): e0018, 2021. tab, graf
Article in English | LILACS | ID: biblio-1288632

ABSTRACT

ABSTRACT Objective: To describe ocular surface findings in impression cytology obtained from healthy rabbit conjunctiva treated with interferon alpha-2b eyedrop, and compare them to findings after use of mitomycin C 0.02%. Methods: An experimental study using a rabbit model was performed between September 2013 and October 2014 at the Faculdade de Medicina de Marília, Universidade Federal de São Paulo, Clínica de Olhos Moacir Cunha. Thirty New Zealand white rabbits were divided into 6 groups and received interferon alpha-2b or mitomycin C 0.02%. Impression cytology (IC) was performed prior to topical applications and at15, 30 and 60 days of use. The following variables were analyzed in impression cytology: goblet cells, cellularity, cell-to-cell adhesion, nucleus/cytoplasm ratio, nuclear chromatin, inflammatory cells keratinization, and cytomegaly. Results: The major findings in impression cytology after us of interferon alpha-2b included loss of goblet cells (50.8%), reduced cell-to-cell adhesion (26.2%), abnormal nucleus/cytoplasm ratio (20%) and reduced cellularity (15.4%). After use of mitomycin C 0.02%, the most common changes included loss of goblet cells (46.2%), abnormal nucleus/cytoplasm ratio (25.6%), less cell-to-cell adhesion (23.1%), and reduced cellularity (20.5%). There were no significant differences in any variable when comparing impression cytology after interferon alpha-2b and after mitomycin C 0.02%. Goblet cell loss was more pronounced at days 30 and 60, as compared to impression cytology at day 15 for both drugs. Conclusion: The loss of goblet cells, reduced cell-to-cell adhesion and cellularity, along with abnormal nucleus/cytoplasm ratio were the most common findings in impression cytology after use of interferon alpha-2b. These findings are similar to those described for use of mitomycin C 0.02%. ..


RESUMO Objetivo: Descrever os achados em citologia de impressão de conjuntiva sadia de coelho submetida ao uso de colírio de interferon alfa-2b e compará-los ao que foi encontrado após uso da mitomicina C 0,02%. Métodos: Estudo experimental realizado em modelo animal no período entre setembro de 2013 e outubro de 2014 nas dependências da Faculdade de Medicina de Marília, da Universidade Federal de São Paulo e da Clínica de Olhos Moacir Cunha. Trinta coelhos albinos da raça Nova Zelândia foram divididos em seis grupos e receberam interferon alfa-2b ou mitomicina C. A citologia de impressão foi realizada antes do início dos colírios e após 15, 30, 60 dias de seu uso. As seguintes variáveis foram analisadas na citologia de impressão: células caliciformes, celularidade, adesão intercelular, razão núcleo/citoplasma, cromatina, células inflamatórias, queratinização e citomegalia. Resultados: Os principais achados na citologia de impressão após o uso do interferon alfa-2b foram a redução de células caliciformes (50,8%), a diminuição da adesão intercelular (26,2%), a alteração da razão N/C (20%) e a redução da celularidade (15,4%). Após o uso da mitomicina C 0,02%, foram mais frequentes a redução das células caliciformes (46,2%), a alteração da razão N/C (25,6%), a adesão intercelular (23,1%) e a redução da celularidade (20,5%). Não houve diferença estatisticamente significante para nenhuma das variáveis estudas quando se compararam as citologias de impressão após interferon alfa-2b com as citologias de impressão após mitomicina C 0,02%. Independentemente da substância utilizada, as citologias colhidas 30 e 60 dias após início das drogas apresentaram maior redução de células caliciformes quando comparadas com as citologias de impressão colhidas após 15 dias. Conclusão: A redução das células caliciformes, a diminuição da adesão intercelular, a alteração da razão N/C e a diminuição da celularidade foram as alterações mais frequentes na citologia de impressão colhida após o uso de interferon alfa-2b. Os achados em citologias de impressão após o uso de interferon alfa-2b são semelhantes àqueles encontrados após o uso da mitomicina C 0,02%.


Subject(s)
Animals , Rabbits , Mitomycin/pharmacology , Conjunctiva/cytology , Cornea/cytology , Interferon alpha-2/pharmacology , Carcinoma, Squamous Cell/drug therapy , Cellulose , Cytological Techniques , Mitomycin/therapeutic use , Conjunctiva/drug effects , Conjunctiva/ultrastructure , Conjunctival Neoplasms/drug therapy , Cell Culture Techniques , Cornea/drug effects , Cornea/ultrastructure , Cytodiagnosis/methods , Interferon alpha-2/therapeutic use , Micropore Filters
2.
Rev. enferm. Inst. Mex. Seguro Soc ; 28(2): 92-101, Abr-Jun. 2020. graf
Article in Spanish | LILACS, BDENF | ID: biblio-1121645

ABSTRACT

Introducción: para garantizar la información y la atención de calidad, la Organización Mundial de la Salud, la Organización Panamericana de la Salud y las normas oficiales del cáncer cervicouterino y los sistemas de salud en México sugieren fortalecer los sistemas de información en salud con el uso de herramientas tecnológicas. Objetivo: el propósito de este estudio es conocer la factibilidad de un proyecto para la innovación de procesos, a través de un sistema electrónico para los registros de las citologías cervicales. Metodología: estudio observacional, transversal, prospectivo, realizado del 4 al 25 de junio de 2018 en la Unidad de Cuidados Integrales e Investigación en Salud de la Universidad Autónoma de San Luis Potosí, México. Se estudió al universo del personal sanitario que implementa el Programa de Detección Oportuna de Cáncer Cervico Uterino, con 7 participantes: personal directivo (2) y operativo (5). Resultados: las políticas y recursos institucionales permiten la implementación del proyecto, pues consideran tendría impacto positivo en la atención. Conclusiones: actualmente, la totalidad del personal cuenta con las competencias básicas para el manejo de sistemas electrónicos.


Introduction: To guarantee quality information and care, World Health Organization, Pan American Health Organization and the Official Standards of Cervical Cancer and Health Systems in Mexico suggest strengthening health information systems with the use of technological tools. Objective: The purpose of the study is to know the feasibility of a project for process innovation, through an electronic system for records of cervical cytologies. Methods: An observational, cross-sectional, prospective study conducted from June 4 to 25, 2018 in the Unit of Integral Care and Health Research of the Autonomous University of San Luis Potosí, Mexico. The universe of health personnel that implements the Timely Detection of Cervical Cancer Program was studied, 7 participants: managerial staff (2) and operative staff (5). Results: Institutional policies and resources allow for the implementation of the project, as they consider it would have a positive impact on care. Conclusions: Currently, all the staff has the basic skills for the management of electronic systems.


Subject(s)
Humans , Pan American Health Organization , World Health Organization , Information Systems , Technological Development , Uterine Cervical Diseases , Feasibility Studies , Nursing Records , Cross-Sectional Studies , Prospective Studies , Cytological Techniques , Papanicolaou Test , Observational Study , Mexico
3.
Rev. cuba. med. trop ; 72(1): e500, ene.-abr. 2020. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1126700

ABSTRACT

Introducción: Existen pocos estudios sobre la circulación del virus del papiloma humano en mujeres ecuatorianas, particularmente residentes en el Cantón Cañar. Objetivo: Determinar la circulación del virus del papiloma humano, las alteraciones en la citología cérvico-vaginal de mujeres cañaríes y el comportamiento de algunas variables sociodemográficas y clínico-epidemiológicas. Métodos: Estudio analítico de corte transversal desde julio 2017-septiembre 2018. Se colectaron células cervicouterinas de 100 mujeres entre 15 y 55 años de edad para determinar la infección viral y alteraciones citológicas. Se investigó la asociación entre variables sociodemográficas y clínico-epidemiológicas con la infección viral. Resultados: El 51 por ciento (51/100) de las mujeres examinadas resultó positivo al virus, con predominio de los genotipos oncogénicos. El genotipo 31 fue el más frecuente (56,9 por ciento; 29/51), seguido por el genotipo 58 (43,1 por ciento; 22/51). Las mujeres mayores de 50 años, tenían una probabilidad menor de estar infectadas (3,9 por ciento; 2/51). La probabilidad de infección fue mayor en mujeres solteras, con antecedentes de infecciones de transmisión sexual, que padecían procesos cervicales inflamatorios, y en las fumadoras. La infección con genotipo 66 estuvo asociada al uso de anticonceptivos hormonales (53,3 por ciento; 8/15); p= 0,045, RP= 3,08 IC95 por ciento (1,00-9,46). Se obtuvo el 97 por ciento de citologías negativas para malignidad; no se diagnosticaron casos con lesiones de alto grado. Conclusiones: La elevada prevalencia de infección con genotipos oncogénicos en contraste con la baja frecuencia de citologías positivas, indica la necesidad de implementar programas eficientes para la detección precoz del cáncer cervicouterino en la población del Cañar y divulgar campañas de educación sexual y reproductiva(AU)


Introduction: Few studies are available about the circulation of human papillomavirus among Ecuadorian women, particularly those from Cañar Canton. Objectives: Determine the circulation of human papillomavirus, alterations in the cervical-vaginal cytology of women from Cañar Canton, and the behavior of some sociodemographic and clinical-epidemiological variables. Methods: An analytical cross-sectional study was conducted from July 2017 to September 2018. Cervical cells were collected from 100 women aged 15-55 years to determine viral infection and cytological alterations. An analysis was performed of the relationship of sociodemographic and clinical-epidemiological variables to viral infection. Results: Of the women examined, 51 percent; (51/100) tested positive for the virus, with a predominance of oncogenic genotypes. Genotype 31 was the most common (56.9 percent;; 29/51), followed by genotype 58 (43.1 percent; 22/51). Women aged over 50 years had a lesser probability of being infected (3.9 percent;; 2/51). Infection probability was greater among single women, with a history of sexually transmitted infections, who suffered from inflammatory cervical processes, and smokers. Infection by genotype 66 was associated to the use of hormonal contraceptives (53.3 percent;; 8/15); p= 0.045, PR= 3.08 CI95 percent; (1.00-9.46). Of the sample cytologies, 97 percent; were negative for malignancy; no case was diagnosed of high-grade lesions. Conclusions: The high prevalence of infection by oncogenic genotypes, as opposed to the low frequency of positive cytologies, points to the need to implement efficient programs aimed at early detection of cervical cancer in the population of Cañar Canton, as well as sexual and reproductive education campaigns(AU)


Subject(s)
Humans , Female , Papillomavirus Infections/pathology , Papillomavirus Infections/epidemiology , Cross-Sectional Studies , Cytological Techniques/methods , Ecuador , Genotype
4.
Rev. bras. anal. clin ; 52(1): 99-100, 20200330. tab
Article in Portuguese | LILACS | ID: biblio-1116506

ABSTRACT

O novo coronavírus (SARS-Coronavírus-2: SARS-Cov-2) foi inicialmente relatado em 2019, em Wuhan, China, onde o aparecimento de muitos casos inexplicáveis de pneumonia severa deixou em alerta todos os serviços de saúde do mundo. A Organização Mundial da Saúde (OMS) declarou recentemente uma pandemia, com mais de um milhão de casos relatados até o momento de COVID-19. A relação da fisiopatologia deste novo agente infeccioso associado ao comportamento dos achados laboratoriais do exame do líquor-LCR, através das descrições de casos e relatos, é importante para a análise, interpretação e apoio diagnóstico.


The new coronavirus (SARS-Coronavirus-2: SARS-Cov-2), was initially reported in 2019 in Wuhan, China, where the appearance of many unexplained cases of severe pneumonia has put all health services on alert of the world. The World Health Organization (WHO) recently declared a pandemic, with more than 1,000,000 cases reported to date as of COVID-19. The pathophysiological relationship of this new infectious agent associated with the behavior of laboratory findings of Cerebrospinal Fluid (CSF) examination, through case descriptions and reports, are important for analysis, interpretation and diagnostic support.


Subject(s)
Humans , Cerebrospinal Fluid , Cytological Techniques , Coronavirus Infections , Coronavirus , Neurotology
5.
Rev. bras. cancerol ; 66(1)20200129.
Article in Portuguese | LILACS | ID: biblio-1088000

ABSTRACT

Introdução: O exame citopatológico é utilizado para detecção precoce das lesões precursoras do câncer do colo uterino. Objetivo: Avaliar os indicadores de qualidade de acordo com o Manual de Gestão da Qualidade para Laboratório de Citopatologia. Método: Verificaram-se os laudos das fichas de requisição dos exames citopatológicos do laboratório clínico da Pontifícia Universidade de Goiás (LC-PUC-Goiás) entre janeiro de 2013 e dezembro de 2017. Resultados: Do total de 6.809 diagnósticos, observaram-se 99,4% (6.768/6.809) satisfatórios, sendo 91,3% (6.215/6.809) resultados negativos, 8,1% (553/6.809) diagnósticos com anormalidades citológicas e 0,6% (41/6.809) de exames insatisfatórios. O índice de positividade dos anos de 2013 a 2017 foram 10,5%, 7,9%, 8,6%, 6,8% e 5,3%, respectivamente. O percentual de exames compatíveis com lesão intraepitelial de alto grau (HSIL) entre os exames satisfatórios no ano de 2013 foi de 1,3%; 2014: 1,0%; 2015: 0,5%; 2016: 0,6%; e 2017: 0,7%, resultados dentro do estabelecido, ≥0,4%. A relação de células escamosas atípicas (ASC)/satisfatórios demostrou valores acima do estabelecido nos anos de 2013 com 6,8% e 2015 com 6,1%. Segundo o Manual de Gestão para Controle de Qualidade, espera-se que, no máximo, 4% a 5% de todos dos exames sejam classificados como ASC. Valores acima de 5% necessitam de uma atenção diferenciada. Conclusão: É de suma importância a educação continuada dos profissionais que participam de todas as etapas do processo, da fase pré-analítica à analítica, para que possíveis erros possam ser corrigidos e medidas preventivas tomadas para uma melhor qualidade na interpretação dos exames citopatológicos.


Introduction: The cytopathological examination is used for early detection of cervical cancer precursor lesions. Objective: Evaluate the quality indicators according to the Quality Management Manual for the Cytopathology Laboratory. Method: The results of the request forms of cytopathological examinations of the Clinical Laboratory of the Pontifical University of Goiás (LC-PUC-Goiás) were verified between January 2013 and December 2017. Results: Of 6,809 diagnoses in total, 99.4% (6,768/6,809) were satisfactory, 91.3% (6,215/6,809) were negative, 8.1% (553/6,809) presented cytological abnormalities and 0.6% (41/6,809) were unsatisfactory. The Positivity Index from 2013 to 2017 was 10.5%, 7.9%, 8.6%, 6.8% and 5.3%, respectively. The percentage of examinations with high-grade intraepithelial lesion (HSIL) among satisfactory examinations in 2013 was 1.3%, in 2014, 1.0%, in 2015, 0.5%, in 2016, 0.6 % and in 2017, 0.7%, results within the established ≥ 0.4%. The atypical squamous cells (ASC)/satisfactory ratio showed values above the standard figures in 2013 with 6.8% and 2015 with 6.1%. According to the Quality Control Management Manual, it is expected that, at the most, 4% to 5% of all exams be classified as ASC. Values above 5% demand differentiated attention. Conclusion: It is of the utmost importance the continued education of professionals who participate in all stages of the process, from the pre-analytical to the analytical phase, so that possible errors can be avoided and preventive measures taken for better quality interpretation of the cytopathological examinations.


Introducción: El examen citopatológico se utiliza para la detección temprana de lesiones precursoras de cáncer cervical. Objetivo: Evaluar los indicadores de calidad de acuerdo con el Manual de Gestión de Calidad para el laboratorio de citopatología. Método: Se verificaron los informes de los formularios de solicitud para los exámenes citopatológicos del Laboratorio Clínico de la Pontificia Universidad de Goiás (LC-PUC-Goiás), de enero de 2013 a diciembre de 2017. Resultados: Del total de 6.809 diagnósticos, se observarán 99,4% (6.768/6.809) diagnósticos satisfactorios, 91,3% (6.215/6.809) resultados negativos, 8,1% (553/6.809) diagnósticos con anomalías citológicas y 0,6% (41/6.809) exámenes insatisfactorios. El índice de positividad de 2013 a 2017 fue de 10,5%, 7,9%, 8,6%, 6,8% y 5,3% respectivamente. El porcentaje de exámenes compatibles con lesiones intraepiteliales de alto grado (HSIL) entre los exámenes satisfactorios en 2013 fue de 1,3%; 2014: 1,0%; 2015: 0,5%; 2016: 0,6%; y 2017: 0,7%, resultados dentro de lo establecido, ≥0,4%. La relación células escamosas atípicas (ASC)/satisfactorio fue más alta que la establecida en 2013 con 6,8% y 2015 con 6,1%. Según el Manual de Gestión de Control de Calidad, se espera que un máximo del 4% al 5% de todos los exámenes se clasifiquen como ASC. Los valores superiores al 5% requieren una atención diferente. Conclusión: Es de suma importancia la educación continua de los profesionales que participan en todas las etapas del proceso, desde la fase preanalítica hasta la analítica, para que se puedan corregir los posibles errores y se tomen medidas preventivas para una mejor calidad en la interpretación de los exámenes citopatológicos.


Subject(s)
Humans , Female , Quality Control , Uterine Cervical Neoplasms/diagnosis , Cervix Uteri/cytology , Quality Assurance, Health Care , Brazil , Uterine Cervical Neoplasms/prevention & control , Mass Screening/standards , Retrospective Studies , Cytological Techniques , Cytodiagnosis/standards , Papanicolaou Test/standards
6.
Int. j. morphol ; 37(4): 1331-1334, Dec. 2019. graf
Article in English | LILACS | ID: biblio-1040133

ABSTRACT

Obesity and its comorbidities are becoming epidemic in the Western world. Beta cell mass estimation is an important indicator to track the progression of insulin resistance/type 2 diabetes, particularly in experimental studies, where it can be performed with stereological tools in an unbiased way. In this work, we present a simple protocol that can contribute to doing the practice of estimating the mass of beta cells more frequent and reproducible. As with any quantitative study, the necessary precautions regarding sampling and randomness must be respected.


La obesidad y sus comorbilidades se están convirtiendo en una epidemia en el mundo occidental. La estimación de la masa de células beta es un indicador importante para rastrear la progresión de la resistencia a la insulina/diabetes tipo 2, particularmente en estudios experimentales, donde se puede realizar con herramientas estereológicas de manera imparcial. En este trabajo presentamos un protocolo simple que puede contribuir a que la práctica de estimar la masa de células beta sea más frecuente y reproducible. Como en cualquier estudio cuantitativo, deben respetarse las precauciones necesarias con respecto al muestreo y la aleatoriedad.


Subject(s)
Humans , Cytological Techniques/methods , Islets of Langerhans/cytology , Insulin-Secreting Cells
7.
Rev. cuba. med ; 58(3): e1224, jul.-set. 2019.
Article in Spanish | LILACS, CUMED | ID: biblio-1139024

ABSTRACT

Introducción: El enfrentamiento diagnóstico de las lesiones sospechosas de cáncer pulmonar ha cambiado en los últimos años. Objetivo: Describir el primer caso diagnosticado en Cuba de carcinoma de pulmón por aspiración transbronquial por aguja fina guiada por ultrasonografía endobronquial. Presentación del caso: Se presenta un caso de carcinoma indiferenciado de células pequeñas. El diagnóstico se obtiene mediante la realización de una citología aspirativa con aguja fina de ganglios mediastinales, transbroncoscópica y guiada por ultrasonido endobronquial. Conclusiones: El uso de EBUS-TBNA es una herramienta con un alto rendimiento diagnóstico, con escasas complicaciones descritas y debe considerarse como una posibilidad en el estudio de lesiones adyacentes a la vía aérea central(AU)


Introduction: The diagnostic confrontation of lesions suspected of lung cancer has changed in recent years. Objective: To describe the first case of lung carcinoma, diagnosed in Cuba by endobronchial ultrasound-guided transbronchoscopic fine needle aspiration cytology. Case report: A case of undifferentiated small cell carcinoma is reported. Diagnosis is obtained by performing a fine needle aspiration cytology of the mediastinal lymph nodes, transbronchoscopic and guided by endobronchial ultrasound. Conclusions: The use of EBUS-TBNA is a tool with high diagnostic yield, with few described complications and should be considered as a possibility in the study of lesions adjacent to the central airway(AU)


Subject(s)
Humans , Male , Female , Cytological Techniques/methods , Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods , Lung Neoplasms/diagnostic imaging
8.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4716, 01 Fevereiro 2019. tab
Article in English | LILACS, BBO | ID: biblio-998227

ABSTRACT

Objective: To qualitatively investigate whether a prototype brush composed of metal bristles collects oral epithelial cells effectively for cytological evaluation of oral mucosal lesions. Material and Methods: Twenty patients with suspicious oral mucosal lesions were enrolled. Patients were asked to gargle with saline and to deposit the oral rinse into specimen cup. Then, oral mucosal cell samples were collected using a metal oral brush, via sweeping motion. Punch biopsy was performed for histological examination. All samples were evaluated with liquid based cytology (LBC) according to the cellularity, the depth of the epithelial layer, cellular integrity by an oral pathologist. Results: Oral rinse provided samples with 100% cellular integrity and cellularity, mostly from the intermediary layers. With metal brush, both inadequate cellularity and cellular integrity was observed in 25% of the cases. Cellular integrity was adequate in 65%, cellularity was adequate in 45% of the lesions. Samples were dominantly from the intermediary layers, but in one case, metal brush collected cells from the parabasal layer. Conclusion: The narrow spiral pitch and width of metal bristles may have resisted to release the cellular samples collected. With adjustment of the spiral pitch and diameter of metal brush bristles, its' efficacy could be enhanced.


Subject(s)
Humans , Biopsy , Mouth Neoplasms/diagnosis , Early Diagnosis , Mouth Mucosa/pathology , Turkey , Cytological Techniques/methods , Cytodiagnosis
9.
Rev. medica electron ; 41(1): 203-210, ene.-feb. 2019.
Article in Spanish | LILACS, CUMED | ID: biblio-991338

ABSTRACT

RESUMEN El cáncer cérvico uterino, causa alrededor de 250 000 muertes anuales en el mundo y alrededor de 400 en Cuba, a pesar del esfuerzo que realiza el MINSAP, a través del Programa de Pesquisaje. Con el mismo se puede obtener el diagnóstico de lesiones precursoras del cáncer de cuello uterino, este diagnóstico citológico se realiza en Cuba a través del método de Richard y Barron que demuestra que existe un progreso citológico aparente hasta llegar al cáncer, que comienza con neoplasia intraepitelial (NICI a NICIII y carcinoma in situ), hasta finalmente el cáncer invasor. Por otro lado existe el método de Bethesda que responde casi todas las interrogantes que la citología plantea para su enfrentamiento, evidentemente los mayores aportes y revisiones se enfocan al manejo de las citologías atípicas de significado incierto, ya que no sólo presentan un mayor número de posibles evaluaciones, sino que representan el mayor porcentaje de citologías alteradas y la inclusión del VPH en las lesiones de bajo grado. En Cuba todavía se clasifica por el método de Richard y no se utiliza el Bethesda. Por la alta incidencia de esta entidad el propósito de este trabajo es emitir consideraciones sobre la implementación del sistema de Bethesda en el diagnóstico citológico de lesiones precancerosas del cérvix.


ABSTRACT The cervical-uterine cancer causes almost 250 000 death a year around the world and around 400 in Cuba in spite of the efforts made by the Public Health Ministry through the Screening Program. With it, the diagnosis of lesions that are predecessors of the cervical cancer could be reached. This cytological diagnosis is carried out through the Richard and Barron method, showing that there is an apparent cytological progress leading to the cancer that begins with intraepithelial neoplasia (NICI and NICIII and carcinoma in-situ) and ends in the invasive cancer. From the other hand there is the Bethesda methods answering to all the questions cytology ask for confronting it. Obviously the biggest contributions and reviews are focused in the management of the atypical cytologies with uncertain significance since they not only have a higher number of possible evaluations, but also represent the highest percent of the altered cytologies and the inclusion of the HPV in low grade lesions. The classification in Cuba is still made by the Richard method and the Bethesda one is not used. Due to the high incidence of this entity, the aim of this article is exposing considerations on the implementation of the Bethesda system in the cytological diagnosis of cervix pre-cancerous lesions.


Subject(s)
Humans , Female , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/virology , Cytological Techniques/standards , Papillomavirus Infections/diagnosis , Papillomavirus Infections/pathology , Papillomavirus Infections/virology , Biopsy, Fine-Needle/methods , National Health Programs , Preventive Health Services , Disease Prevention
10.
Article in English | WPRIM | ID: wpr-739591

ABSTRACT

PURPOSE: Fine-needle aspiration biopsy (FNAB) can be used to diagnose thyroid cancer and other tumors. Although FNAB without negative pressure (FNAB−P) reduces the risk of blood contamination, FNAB with negative pressure (FNAB+P) increases the sensitivity of the biopsy results. Therefore, we performed a randomized study of FNAB with or without negative pressure to identify the better diagnostic method. METHODS: Between March 2016 and February 2017, 172 consecutive patients were enrolled to investigate >0.5 cm nodules with indeterminate or suspicious malignant features. Patients were randomly assigned to the FNAB+P group (a 50 mL syringe was used to provide negative pressure) or to the FNAB−P group (passive collection of blood in the needle's hub). The 2 methods' diagnostic adequacy and quality were evaluated using an objective scoring system. The study's protocol was registered with the World Health Organization Clinical Research Information Service (http://cris.nih.go.kr/cris, KCT0001857). RESULTS: The patients were randomly assigned to the FNAB+P group (n = 86) or the FNAB−P group (n = 86). There were no significant intergroup differences in nodule position, size, age, consistency, calcification, BRAF mutation, or pathology. Evaluation of diagnostic adequacy parameters revealed no significant differences in background blood/clot (P = 0.728), amount of cellular material (P = 0.052), degree of cellular degeneration (P = 0.622), degree of cellular trauma (P = 0.979), or retention of appropriate architecture (P = 0.487). Furthermore, there was no significant intergroup difference in the diagnostic quality (P = 0.634). CONCLUSION: This prospective randomized study failed to detect significant differences in the diagnostic adequacy and quality of FNAB with or without negative pressure. Therefore, the examiner may select whichever FNAB method they prefer.


Subject(s)
Biopsy , Biopsy, Fine-Needle , Cytological Techniques , Humans , Information Services , Methods , Pathology , Prospective Studies , Syringes , Thyroid Gland , Thyroid Neoplasms , Thyroid Nodule , World Health Organization
11.
Postgrad. Med. J. Ghana ; 8(2): 93-100, 2019. ilus
Article in English | AIM, AIM | ID: biblio-1268724

ABSTRACT

Introduction: An estimated 99% of largely preventable maternal deaths occur across developing regions characterized by a cascade of well-established delays at all levels. Data on community deaths remains scanty hence a wide reliance on institutional data. Target 3.1 of the SDG aims to attain a global reduction of less than 70/100000 live births by 2030. Ghana's MMR of 350/100000 live births is accounted for by commensurately high MMR across its 10 administrative regions. The MMR of the Eastern region, ranked among the top 5 by MMR, has exceeded the national average since 2011. Studies are largely cross sectional, not computing individual risk. This study aimed to (1) identify trends of institutional maternal deaths, (2) estimate magnitudes of individual risk with exposure to specific factors and (3) recommend preventive strategies. Methodology: Records on 479 maternal deaths were compared with 616 records on obstetric clients over the same period that did not die from 2011 - 2016 using an unmatched case control study design. Data were analyzed with epi info 3.5.4. Results: Maternal deaths were mainly direct. Controls were largely urban residents, with traceable addresses, engaged in formal occupations, of higher educational backgrounds and ANC attendants. Leading cause of death was obstetric hemorrhage. Most abortions, mainly cases, were unsafe. Mean maternal age was higher for cases. Maternal age of 11 - 20 and ≥ 35, rural residence, underlying medical conditions, informal occupations, multi- and grand multiparity increased risk of maternal deaths, while, ≥ SHS education and ANC ≥ 4 reduced risk of death. Recommendations: Health policies to address concerns of fertility control for adolescents and clients ≥ 35, inequitable access to CEmONC services, quality ANC, low literacy and awareness on the abortion law should be prioritized


Subject(s)
Cytological Techniques , Early Detection of Cancer , Ghana , Papanicolaou Test , Tertiary Care Centers , Uterine Cervical Neoplasms/diagnosis
12.
Rev. chil. cir ; 70(6): 523-528, dic. 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-978025

ABSTRACT

Introducción: El cáncer anal ha experimentado un aumento de incidencia en los últimos años. Está mediado por el VPH y precedido de cambios precancerosos planteando la posibilidad de dirigir los esfuerzos preventivos hacia los grupos de alto riesgo. Sigue siendo controvertida la indicación de cribado y los métodos de detección ideales. Objetivo: Validar las pruebas de cribado implementadas en la actualidad comparadas con la biopsia como "gold standard". Material y Métodos: Estudio transversal con recogida de datos prospectiva, en una cohorte de hombres VIH+ que tienen sexo con hombres, pertenecientes al Hospital Gregorio Marañón e Infanta Leonor en un periodo de 2 años. Resultados: Se seleccionaron 179 pacientes con 286 visitas a la consulta de screening en las que se llevaron a cabo 3 pruebas de cribado en paralelo (citología anal, genotipado del VPH y anoscopia de alta resolución (AAR) con toma de biopsia dirigida sobre zona sospechosa o aleatoria). La sensibilidad y especificidad para la detección de displasia de alto grado y cáncer y su grado de concordancia con la biopsia fue la siguiente: citología 3,23%/94,43% (k: 0,03), genotipado de VPH de alto riesgo 90,32%/27,45% (k: 0,05), AAR 32,26%/87,45 (k: 0, 17) siendo el rendimiento diagnóstico de las tres pruebas muy bajo. Conclusión: La citología presenta un rendimiento diagnóstico muy bajo comparado con el genotipado que representa el mayor. A la luz de nuestros resultados, los protocolos clínicos tal y como vienen desarrollándose en la actualidad deberían de ser abandonados.


Introduction: The incidence of anal cancer has increased in recent years. It is mediated by HPV and preceded by precancerous changes, raising the possibility of directing preventive efforts towards high-risk groups. The indication of screening remains controversial and which methods would be the ideal ones. Objective: To validate the screening tests established actually, comparing it with the biopsy considered as the "gold standard". Materials and Methods: A cross-sectional study was performed, with prospective data collection in a cohort of VIH+ patients, who have male homosexual anal relations, belonging to Gregorio Marañón and Infanta Leonor Hospitals in a period of 2 years. Results: A total of 179 patients were selected with 286 visits to the screening Outpatient Clinic in which 3 parallel screening tests were performed (anal cytology, HPV genotyping and high resolution anoscopy (AAR) with a biopsy directed on a suspicious or random area). The sensitivity and specificity for the detection of high-grade dysplasia and cancer and their degree of agreement with the biopsy was as follows: cytology 3.23%/94.43% (k: 0.03), high HPV genotyping. risk 90.32%/27.45% (k: 0.05), AAR 32.26%/87.45 (k: 0, 17), the diagnostic accuracy of the three tests being very low. Conclusion: Cytology shows a very low diagnostic accuracy compared to the genotype that represents the highest one. In light of our results, clinical protocols as they are currently being developed should be abandoned.


Subject(s)
Humans , Male , Adult , Anus Neoplasms/pathology , Carcinoma, Squamous Cell/pathology , Mass Screening/methods , Homosexuality, Male , Anal Canal/cytology , Anal Canal/pathology , Anal Canal/virology , Anal Canal/diagnostic imaging , Anus Neoplasms/virology , Papillomaviridae/genetics , Precancerous Conditions , Biopsy , Carcinoma, Squamous Cell/virology , Carcinoma, Squamous Cell/diagnostic imaging , Cross-Sectional Studies , Predictive Value of Tests , ROC Curve , Cytological Techniques , Sensitivity and Specificity , HIV Seropositivity , Proctoscopy/methods , Papillomavirus Infections/pathology , Early Detection of Cancer/methods , Genotyping Techniques
13.
Int. j. morphol ; 36(3): 962-968, Sept. 2018. graf
Article in English | LILACS | ID: biblio-954215

ABSTRACT

This study was aimed at comparing the commonly used metachromatic stains viz., Papanicolaou stain, WrightGiemsa, Toluidine blue and Methylene blue in the assessment of cell types of the oestrous cycle in rats. Eight female Sprague-Dawley rats aged 8-9 weeks were used for this assessment. Cotton Swabs were gently inserted in the animals vagina to obtain cells from which they were then transferred to glass slides for staining and evaluation under microscopy. The different cell types were compared for their morphological features and clarity of cellular detail under all four stains. The application, advantages and limitations of all stains were then discussed. It was concluded that the selection of the most effective stain in the assessment of vaginal cytology depends on their application to clinical or research which was based on the cellular detail of interest, time, cost and availability of each staining procedure.


El presente estudio tuvo como objetivo comparar las tinciones metacromáticas comúnmente utilizadas, Wright's-Giemsa, azul de toluidina, azul de metileno y tinción de Papanicolaou, en la evaluación de los tipos de células del ciclo estral en ratas. El estudio se realizó en ocho ratas hembras SpragueDawley, con edades entre 8 y 9 semanas, y se usaron hisopos vaginales de algodón para preparar portaobjetos. Los diferentes tipos de células se compararon por sus características morfológicas y claridad en las cuatro tinciones. La aplicación, ventajas y limitaciones de todas las tinciones fueron discutidas. Se concluye que la selección de la tinción más efectiva en la evaluación de la citología vaginal depende de su uso, es decir, clínico o de investigación, el detalle celular de interés, tiempo, costo y disponibilidad.


Subject(s)
Animals , Female , Rats , Staining and Labeling/methods , Vagina/cytology , Cytological Techniques/methods , Estrous Cycle , Azure Stains , Tolonium Chloride , Coloring Agents , Papanicolaou Test , Methylene Blue
14.
Pesqui. vet. bras ; 38(1): 53-58, Jan. 2018. tab
Article in English | LILACS, VETINDEX | ID: biblio-895545

ABSTRACT

Reproductive diseases, mainly endometritis, are important hurdles in cattle raising, In the current study we evaluated gross, bacteriological, cytological, and histological findings from selected sites of the genital from 23 slaughtered cows and tested whether there is an association between these findings and the probability of reaching a reliable diagnosis. The results from the examinations of macroscopic aspects of uterine secretions, the cytological, bacteriological, and histopathological findings were then correlated. There was no significant correlation (P>0.05) of the statistical data from different parts of the genital tract. Trueperella pyogenes and Escherichia coli were isolated from the vagina in 3/23 cases. In only 2/23 samples Enterococcus faecalis and a gram-negative, oxidase-positive bacteria were isolated from the cervix uteri. Only Staphylococcus epidermidis, in 1/23 case, was isolated from the uterus. Histopathological findings in uterus from samples of Groups II (moderate lesions) and III (severe lesions) did not translated in grossly visible changes. Samples from reproductive tracts with secretion in the vagina and cervix uteri had no detectable changes in the other parameters analyzed from this portion. Uterus with positive bacterial culture had evidence of ascendant inflammation judging by the high granulocyte count in the three analyzed portions. This study reinforces that vaginitis and cervicitis in the cow diagnosed only by clinical examination does not reflect the real status of the uterine health. For this reason, treatment of uterine disorders should be conducted based on reliable tests to determine the appropriate therapy for each situation.(AU)


Doenças reprodutivas causam altas perdas econômicas nos rebanhos bovinos, sendo a endometrite uma das alterações mais relevantes. Os objetivos desta pesquisa foram avaliar a associação dos achados fisiopatológicos em exames macroscópicos, bacteriológicos, citológicos e histopatológicos nas porções do trato genital de 23 vacas abatidas, bem como avaliar a necessidade de associação destes exames para efetuar diagnóstico fidedigno. A avaliação macroscópica da secreção, os exames histopatológico, citológico e as bactérias identificadas foram correlacionados. Não houve associação (P>0,05) dos resultados nas diferentes porções do trato genital. Na vagina foram isoladas as bactérias Trueperella pyogenes e Escherichia coli. Na cérvix, em apenas 2/23 (8,6%) amostras isolou-se Enterococcus faecalis e gram negativo oxidase positiva. No útero houve isolamento apenas da bactéria Staphylococcus epidermidis. As amostras histopatológicas classificadas em grupo II e III não apresentaram alterações detectadas no exame macroscópico. As amostras com secreção não fisiológica na vagina e cérvix não apresentaram alterações nos outros exames na porção uterina. A amostra com cultura bacteriológica positiva no útero demonstrou uma infecção ascendente através da alta contagem de granulócitos nas três porções analisadas. O presente estudo reforça o conceito de que a vaginite e cervicite diagnosticadas pelo exame clinico na vaca não retratam o real status da saúde uterina e por esta razão, o tratamento do útero deve ser conduzido com critério, alicerçado nos exames complementares para definir a terapia adequada para cada situação.(AU)


Subject(s)
Animals , Female , Cattle , Endometriosis/diagnosis , Endometriosis/veterinary , Genitalia, Female/microbiology , Cytological Techniques/veterinary , Granulocytes , Reproductive Tract Infections/veterinary , Uterine Cervicitis/veterinary , Vaginosis, Bacterial/veterinary
15.
Rev. chil. obstet. ginecol. (En línea) ; 83(4): 338-351, 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-978105

ABSTRACT

RESUMEN Antecedentes: Un algoritmo puede definirse como un conjunto de operaciones y procedimientos que se deben seguir con el fin de resolver un problema. Objetivo: Conocer el cumplimiento del flujo de decisiones clínicas del protocolo preconizado en los algoritmos de derivación y de confirmación diagnóstica para la citología cervical atípica de significado indeterminado - H1, estipulados en el Programa Nacional de Búsqueda y Control del Cáncer Cervical de Chile. Métodos: Estudio epidemiológico de tipo descriptivo, observacional, cuantitativo y de seguimiento de una cohorte de mujeres portadoras de un primer informe de citología cervical atípica de significado indeterminado - H1, pertenecientes a los consultorios de Atención Primaria de Salud del área Metropolitana Sur de Santiago, Chile. El seguimiento fue a través de la aplicación de los "Algoritmo de derivación a especialista o U.P.C. del primer PAP atípico según la clasificación Bethesda 2001" y "Algoritmos para confirmación diagnóstica". Resultados: Se seleccionaron 446 mujeres con un primer informe H1. El cumplimiento de conductas de acuerdo al algoritmo de derivación fue de 42.4% y las conductas alternativas fue de 5.8%. La adherencia de conducta en los algoritmos para confirmación diagnóstica fue cumplida en un 89.6%. Conclusiones: El cumplimiento de las conductas ajustadas a algoritmo de derivación del primer Pap atípico fue realizado por la mitad de las mujeres y el cumplimiento del algoritmo de confirmación diagnóstica fue realizado por la gran mayoría.


SUMMARY Background: An algorithm can be defined as a set of operations and procedures that must be followed in order to solve a problem. Objective: Determine the compliance of the clinical decisions flow and procedures recommended by the ASCUS results derivation and diagnostic confirmation algorithms established in the National Program of Search and Control of Cervical Cancer of Chile. Methods: An epidemiological, descriptive, observational and quantitative study of a follow up investigation of a cohort of women with ASCUS cytological reports. These women belonging in the health care centers in the South Metropolitan area of Santiago de Chile. The algorithms "The Specialist Derivation Algorithm or UPC for the first atypical Pap according to the Bethesda 2001 classification" and "Diagnosis Confirmation Algorithm" were used for the follow-up process of these patients. Results: Women with a first ASCUS report were selected (n = 446). The compliance of the clinical decisions flow to derivation algorithm was 42.4% and alternative behaviors were 5.8%. In the diagnosis confirmation algorithm was 89.6% the compliance the recommended procedures. Conclusion: Half ASCUS carrier women followed the procedures recommended by the derivation algorithm. In the algorithms of diagnostic confirmation it is met mostly.


Subject(s)
Humans , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Algorithms , Uterine Cervical Neoplasms/epidemiology , Papanicolaou Test/statistics & numerical data , Atypical Squamous Cells of the Cervix/pathology , Primary Health Care , Logistic Models , Uterine Cervical Neoplasms/diagnosis , Epidemiology, Descriptive , Cytological Techniques , Cervical Intraepithelial Neoplasia/diagnosis , Cervical Intraepithelial Neoplasia/epidemiology , Colposcopy , Guideline Adherence , Early Detection of Cancer , Observational Study
16.
Article in English | WPRIM | ID: wpr-777566

ABSTRACT

Manual examination of the peripheral blood smear (PBS) is currently performed on a fraction of samples sent for automated complete cell count. 39 children (age range 0-16.2 years) referred to a private paediatric practice during a 16-month period were retrospectively reviewed. Clinical scenarios, haematological features, laboratory-initiated PBS review, haematologist's PBS review and final diagnosis were described. Clinical indications included isolated thrombocytopenia (n = 10), unexplained bruises (n = 5), acute febrile illnesses (n = 11), anaemia (n = 8) and others (n = 5). The laboratory reviewed the PBS in 30 cases according to preset criteria and made no conclusive remarks. All slides were reviewed by a haematologist and a diagnosis was made in 27 (69%) cases, including 7 (78%) of the nine slides the laboratory did not review. The practice of laboratory-initiated PBS review requires re-evaluation. Haematologist-reviewed PBS is an important diagnostic tool for children with anaemia, bleeding disorders and acute febrile illnesses.


Subject(s)
Adolescent , Anemia , Diagnosis , Child , Child, Preschool , Contusions , Diagnosis , Cytological Techniques , Methods , Female , Fever , Diagnosis , Hematology , Methods , Humans , Infant , Infant, Newborn , Male , Medical Oncology , Methods , Pediatrics , Methods , Retrospective Studies , Thrombocytopenia , Diagnosis
17.
Chinese Journal of Lung Cancer ; (12): 719-726, 2018.
Article in Chinese | WPRIM | ID: wpr-772374

ABSTRACT

Intraoperative pleural lavage cytology is a diagnostic technique used to detect tumor cells and serve as a prognostic parameter for non-small cell lung cancer (NSCLC) patients. In the past several decades, many scholars have been dedicated to clarifying the relationships between positive intraoperative pleural lavage cytology results and postoperative survival as well as tumor recurrence and metastasis. However, the findings remained various due to the inhomogeneity of different research. It has been confirmed that a positive intraoperative pleural lavage cytology result is one of the risk factors for the prognosis of postoperative patients. This study reviewed the advances in research of intraoperative pleural lavage cytology in recent years from several aspects, including clinical significance, influencing factors and possible mechanisms.
.


Subject(s)
Cytological Techniques , Methods , Humans , Intraoperative Period , Lung Neoplasms , Pathology , General Surgery , Pleura , Pathology
18.
Neuroscience Bulletin ; (6): 875-886, 2018.
Article in English | WPRIM | ID: wpr-777022

ABSTRACT

The brain has very high energy requirements and consumes 20% of the oxygen and 25% of the glucose in the human body. Therefore, the molecular mechanism underlying how the brain metabolizes substances to support neural activity is a fundamental issue for neuroscience studies. A well-known model in the brain, the astrocyte-neuron lactate shuttle, postulates that glucose uptake and glycolytic activity are enhanced in astrocytes upon neuronal activation and that astrocytes transport lactate into neurons to fulfill their energy requirements. Current evidence for this hypothesis has yet to reach a clear consensus, and new concepts beyond the shuttle hypothesis are emerging. The discrepancy is largely attributed to the lack of a critical method for real-time monitoring of metabolic dynamics at cellular resolution. Recent advances in fluorescent protein-based sensors allow the generation of a sensitive, specific, real-time readout of subcellular metabolites and fill the current technological gap. Here, we summarize the development of genetically encoded metabolite sensors and their applications in assessing cell metabolism in living cells and in vivo, and we believe that these tools will help to address the issue of elucidating neural energy metabolism.


Subject(s)
Animals , Biosensing Techniques , Brain , Cell Biology , Metabolism , Cytological Techniques , Energy Metabolism , Humans , Luminescent Proteins , Genetics , Metabolism , Time Factors
19.
Pesqui. vet. bras ; 37(12): 1483-1490, dez. 2017. tab
Article in English | LILACS, VETINDEX | ID: biblio-895405

ABSTRACT

Contaminated and infected wounds occur very frequently in veterinary medicine and can cause systemic inflammatory response syndrome, sepsis, and death. This study aimed to test the feasibility of collecting wound material by deep-tissue or punch biopsy for microbial culture, determine the frequency of bacteria in the wound(s) and blood cultures and the susceptibility of these microbes to antimicrobials, and evaluate clinical parameters that could be related to prognosis. Thirty dogs with wounds and signs of SIRS/sepsis were included in this study. Bacteria were isolated from all wounds and 41 bacterial isolates could be identified based on culture of the materials collected by punch biopsy; 53.66% of the isolates were gram-negative, mainly involving Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterococcus spp., and 46.34% were gram-positive bacteria such as Streptococcus spp., Enterococcus spp., and Staphylococcus spp. The survival rate was 66.67%. Based on blood culture analysis, we identified bacteremia in seven patients, predominantly of gram-negative bacteria, which negatively affected patient survival, as six dogs died. Hypoglycemia (≤60mg/dL) and severe hyperglycemia (≥180mg/dL) also negatively affected survival as 23.33% of the hypo/hyperglycemic dogs died. Factors such as blood lactate level at admission and hematocrit levels, and mean arterial pressure were not significantly correlated with death or survival of the dogs.(AU)


As feridas contaminadas e infectadas em cães ocorrem com grande frequência na medicina veterinária e podem causar síndrome da resposta inflamatória sistêmica, sepse e morte. Os objetivos do presente trabalho foram verificar a viabilidade da técnica de coleta de material da ferida por biópsia para realização de cultura microbiana, determinar a frequência das bactérias nas culturas das feridas e hemoculturas e a susceptibilidade destes agentes aos antimicrobianos, bem como avaliar parâmetros clínicos que pudessem ser relacionados ao prognóstico em 30 cães com feridas e sinais de SIRS/sepse. Foram isoladas bactérias de todas as feridas e a técnica de coleta de material para cultura por biópsia permitiu a obtenção de 41 agentes microbianos, sendo isoladas 53,66% bactérias Gram negativas e 46,34% Gram positivas, principalmente Pseudomonas aeruginosa, Klebsiella pneumoniae e Enterococcus spp. As bactérias gram positivas isoladas foram Streptococcus spp., Enterococcus spp. e Staphylococcus spp. A taxa de sobrevivência foi 66,67%. Na hemocultura constatou-se bacteremia em sete pacientes, com predominância de bactérias Gram negativas, o que influenciou negativamente na sobrevivência dos pacientes, pois seis cães vieram a óbito. A hipoglicemia (≤60mg/dL) ou hiperglicemia severa (≥180mg/dL), também influenciaram negativamente a sobrevivência, pois 23,33% dos pacientes hipo/hiperglicêmicos vieram a óbito. Já fatores como nível sérico de lactato na admissão do paciente, pressão arterial média (PAM) e hematócrito não apresentaram correlação estatística com o óbito ou sobrevivência destes pacientes.(AU)


Subject(s)
Animals , Dogs , Wound Infection/complications , Bacteremia/veterinary , Sepsis/veterinary , Blood Culture/veterinary , Cytological Techniques/veterinary
20.
Rev. cuba. obstet. ginecol ; 43(4): 13-22, oct.-dic. 2017. tab
Article in Spanish | LILACS | ID: biblio-901328

ABSTRACT

Introducción: el estudio de las lesiones epiteliales del cérvix constituye una prioridad en la prevención de este cáncer que muestra un incremento evidente de la morbimortalidad, a pesar de programas de pesquiza poblacional. Objetivo: describir el comportamiento de las lesiones epiteliales según variables clínico - epidemiológicas de interés. Métodos: estudio descriptivo retrospectivo para caracterizar el comportamiento de lesiones epiteliales del cuello uterino en las 1 148 pacientes atendidas en la Consulta de Patología de Cuello en el Hospital General Docente de la Isla de la Juventud desde 2014 hasta 2015. Resultados: del total de pacientes, 71 por ciento tenían entre 25 y 51 años de edad, 44 por ciento procede de los Consejos Populares de Santa Fé y Pueblo Nuevo. El inicio de las relaciones sexuales supera los 16 años y el número promedio de partos y abortos no es mayor de dos. Del total, 42 % tenía una citología con infección por el virus del papiloma humano y 30 por ciento acudió por una lesión evidente del cérvix sin una citología alterada y 57 por ciento tenían un área lesional menor a 200 mm2. En los estudios colposcópico e histológico predominaron las lesiones de alto grado con más del 60 por ciento y las lesiones invasoras sólo representaron 4 por ciento. El número de pacientes jóvenes es significativamente alto. No se evidenció un comportamiento anormal de los factores de riesgo clásicos para esta enfermedad. Conclusiones: los resultados de este estudio pueden servir de base para trazar estrategias locales del Sistema de Salud encaminadas a la disminución de la morbimortalidad por cáncer en el territorio(AU)


Introduction: The study of cervix epithelial lesions is a priority in preventing this type of cancer because of the evident morbidity and mortality increase, despite population screening programs. Objective: To describe epithelial lesion behavior according to clinical - epidemiological variables of interest. Methods: A retrospective descriptive study was conducted to characterize the cervix epithelial lesion behavior in 1148 patients treated in the Consultation of Neck Pathology at the General Teaching Hospital of the Isle of Youth from 2014 to 2015. Results: 71 percent of the total number of patients aged between 25 and 51 years, 44 percent came from Santa Fé and Pueblo Nuevo territories. These subjects' first sexual relations were after they were 16 and the average number of deliveries and abortions is less than two. Forty-two percent had human papillomavirus infection confirmed by cytology. Thirty percent came to consultation for an obvious cervix lesion with no cytology altered. Fifty-seven percent had a lesion area less than 200 mm2. The colposcopy and histological studies, high-grade lesions predominated in more than 60 percent. Invasive lesions only represented 4 percent. The number of young patients is significantly high. There was no evidence of abnormal behavior of this disease's classic risk factors. Conclusions: The results of this study can serve as a basis to draw local strategies for the Health System aiming to reduce morbidity and mortality from cancer in the territory(AU)


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Uterine Cervical Neoplasms/prevention & control , Epithelium/injuries , Early Detection of Cancer/methods , Epidemiology, Descriptive , Retrospective Studies , Cytological Techniques/methods , Observational Study
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