Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 497
Arch. endocrinol. metab. (Online) ; 65(6): 684-694, Nov.-Dec. 2021. tab, graf
Article in English | LILACS | ID: biblio-1350000


ABSTRACT Objectives: To assess the prevalence of psychiatric disorders in patients with type 1 diabetes mellitus (T1D) and to compare patients with and without psychiatric disorder. Materials and methods: We made a cross-sectional study including patients with T1D assisted in the outpatient clinics of the Brazilian National Health System. To assess depression and anxiety, we used the PHQ-9 questionnaire and the DSM-5th edition criteria, respectively. B-PAID evaluated the level of emotional distress associated with diabetes; EAT-26, eating disorders; SCI-R, adherence to the proposed clinical treatment. Results: We analyzed 166 patients aged 33 (22-45.2) years, 53.6% female. The prevalence of depression and anxiety was 20.5% and 40.4%, respectively. HbA1c was worse in the depressed (9.0% vs. 8.4%, p = 0.008), in the anxious ones (9.0% vs. 8.3%, p = 0.012) and in the patients with high levels of B-PAID (8.8 % vs. 8.3 %, p = 0.009). There was no difference in the prevalence of complications related to diabetes. Conclusions: The prevalence of psychiatric disorders and emotional distress related to diabetes was high in our population of T1D patients, and depression and high levels of B-PAID were associated with the worse glycemic control.

Humans , Male , Female , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/epidemiology , Psychological Distress , Mental Disorders , Cross-Sectional Studies , Depression/etiology , Depression/epidemiology , Glycemic Control
Arch. latinoam. nutr ; 71(3): 199-207, sept. 2021. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1353212


Las enfermedades mentales representan uno de los mayores problemas de salud pública. El consumo de alimentos ricos en antioxidantes como, frutas y verduras puede disminuir los factores de riesgo. Objetivo. Analizar la ingesta dietética y el riesgo de enfermedades mentales en adultos peruanos. Materiales y métodos. Se realizó un estudio transversal en 393 adultos peruanos, provenientes de las tres regiones del país (costa, sierra y selva). Los datos sociodemográficos, antropométricos se obtuvieron por auto reporte mediante una ficha de registro y el riesgo de enfermedades mentales se determinó con el Cuestionario de Salud General-12 (GHQ-12). Se analizaron los datos mediante el software estadístico IBM SPSS, versión 26. Se utilizó la prueba Chi-cuadrado, considerando un nivel de significancia del 5 %. Resultados. Los participantes que informaron riesgo y presencia de enfermedades mentales reportaron un consumo inadecuado de frutas, verduras y grasas saludables. El consumo adecuado de cereales integrales, frutas y verduras fue significativamente mayor en las mujeres (p<0,05). Sin embargo, más de la mitad de las mujeres demostró estar en riesgo de enfermedades mentales respecto a los hombres (p<0,001). Conclusiones. La ingesta adecuada de alimentos saludables podría resultar beneficiosa en la reducción de los riesgos de las enfermedades mentales en este grupo de población(AU)

Mental illnesses represent one of the biggest public health problems. Consuming foods rich in antioxidants such as fruits and vegetables can lower risk factors. Objective. To analyze the dietary intake and the risk of mental illnesses in Peruvian adults. Materials and methods. A cross-sectional study was carried out in 393 Peruvian adults, who came from the three regions of the country (coast, mountains and jungle). Sociodemographic and anthropometric data were obtained through a registration form and the risk of mental illnesses was determined using the General Health Questionnaire-12 (GHQ-12). The data were analyzed using the statistical software IBM SPSS, version 26. The Chi-square test was used, considering a significance level of 5%. Results. Participants who reported risk and presence of mental illness reported inadequate consumption of fruits, vegetables, and healthy fats. Adequate consumption of whole grains, fruits and vegetables was significantly higher in women (p <0.05). However, more than half of the women proved to be at risk for mental illnesses compared to men (p <0.001). Conclusions. The adequate intake of healthy foods could be beneficial in reducing the risks of mental illness in this population group(AU)q

Humans , Male , Female , Adult , Vegetables , Depression/etiology , Diet, Healthy , Fruit , Mental Disorders/etiology , Mental Disorders/genetics , Antioxidants , Stress, Psychological , Risk Factors , Adult , Life Style
Rev. bras. ginecol. obstet ; 43(9): 676-681, Sept. 2021. tab
Article in English | LILACS | ID: biblio-1351775


Abstract Objective To assess the most common psychological disturbances in women with deep endometriosis and bowel involvement who are waiting surgical treatment and to evaluate what forms of coping are used to solve the problem. Methods This was a cross-sectional observational study of 40 women diagnosed with deep endometriosis and intestinal symptoms. They completed two questionnaires: one for anxiety and depression (Hospital Anxiety and Depression Scale [ HADS]) and the Scale of Mode of Confronting Problems (EMEP, in the Portuguese acronym). Results We found that 77.1% of the patients had anxiety and depression, with anxiety being the most prevalent (87.5% of the patients); 90% of the patients used problem focused and religious introspection as their main modes of confronting problems. Conclusion In the use of the HADS questionary, two psychological aspects were the most present in women with deep endometriosis awaiting surgical treatment: anxiety and depression. The most used forms of coping to solve the problem were problem coping and religious practices.

Resumo Objetivo Avaliar os distúrbios psicológicos mais comuns em mulheres com endometriose profunda e acometimento intestinal que aguardam tratamento cirúrgico e avaliar as formas de enfrentamento que são usadas para resolver o problema. Métodos Estudo observacional transversal com 40 mulheres com diagnóstico de endometriose profunda e acometimento intestinal. As pacientes responderam dois questionários: para ansiedade e depressão (Hospital Anxiety and Depression Scale [HADS, na sigla em inglês) e outro para enfrentamento dos problemas (EMEP). Resultados Constatamos que 77% das pacientess apresentaram ansiedade e depressão, sendo a ansiedade a mais prevalente (87,5%); 90% das pacientes usaram a forma religiosa e focada no problema como sua principal estratégia de enfrentamento. Conclusão Os aspectos psicológicos mais encontrados em mulheres com endometriose profunda e intestinal que aguardam tratamento cirúrgico são ansiedade e depressão. As formas mais usadas de enfrentamento para resolver o problema foram práticas religiosas e focada no problema.

Humans , Female , Endometriosis/surgery , Endometriosis/complications , Anxiety/etiology , Anxiety/epidemiology , Stress, Psychological , Adaptation, Psychological , Cross-Sectional Studies , Surveys and Questionnaires , Depression/etiology , Depression/epidemiology
Arq. bras. oftalmol ; 84(1): 31-36, Jan.-Feb. 2021. tab
Article in English | LILACS | ID: biblio-1153098


ABSTRACT Purpose: Our goal was to analyze the prevalence of depression and anxiety among patients with glaucoma and to identify risk factors related to these disorders. Methods: A cross-sectional study was carried out between August 2016 and August 2017 at the Hospital das Clínicas of Universidade Estadual de Campinas and at the Hospital Oftalmológico de Brasília to evaluate the prevalence of depressive and anxiety disorders among patients diagnosed with glaucoma. All patients underwent a complete ophthalmologic examination with standard automated perimetry to confirm the diagnosis of glaucoma. All participants were asked to complete the Hospital Anxiety and Depression Scale questionnaire. Results: One hundred and twenty-nine patients were included in the study. Seventy-four were men (57.36%) and 55 (42.64%) were women. The mean age of the patients was 70.14 ± 15.8 years. Ninety participants were white (69.77%) and 38 (29.46%) were black. The study demonstrated a prevalence of depression and/or anxiety at 10.08%. Logistic regression revealed that women were at higher risk for anxiety and/or depression (OR: 5.25, p=0.015) and patients with a larger number of comorbidities also were at higher risk for anxiety and/or depressive disorders (OR: 2.82, p=0.038). Conclusion: A significant proportion of patients with glaucoma present with depression and/or anxiety. Females and patients with comorbidities are at greater risk for these disorders.

RESUMO Objetivo: Avaliar a prevalência de transtornos de depressão e ansiedade em pacientes com glaucoma e identificar fatores de riscos associados. Métodos: Estudo transversal em pacientes com glaucoma, avaliados durante Agosto de 2016 e Agosto de 2017 no Hospital das Clínicas da Universidade de Campinas e no Hospital Oftalmológico de Brasília. Todos pacientes foram submetidos à exame oftalmológico completo para confirmar o diagnóstico de glaucoma. Todos pacientes preencheram o questionário "Hospital Anxiety and Depression Scale". Resultados: Foram incluídos 129 pacientes no estudo, sendo 74 homens (57.36%) e 55 (42.64%) mulheres, 90 pacientes eram brancos (69.77%) e 38 (29.46%) eram negros. A idade média foi de 70.14 ± 15.8 anos. O estudo demonstrou uma prevalência de 10.08% de transtornos depressivo e/ou ansiedade. A regressão logística demonstrou que mulheres apresentam maior risco de desenvolver transtornos depressivos e/ou ansiedade (Risco relativo: 5.25, p=0.015), assim como pacientes com maior número de comorbidades clínicas (Risco relativo: 2.82, p=0.038). Conclusão: Uma proporção significativa dos pacientes com glaucoma podem apresentar transtornos de depressão e/ou ansiedade. Pacientes com glaucoma do sexo feminino e que apresentem maiores comorbidades clínicas apresentam maior risco de apresentar esses transtornos.

Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Glaucoma , Depressive Disorder , Anxiety/epidemiology , Anxiety Disorders/epidemiology , Glaucoma/complications , Glaucoma/epidemiology , Prevalence , Cross-Sectional Studies , Surveys and Questionnaires , Depression/etiology , Depression/epidemiology , Depressive Disorder/epidemiology
Arq. neuropsiquiatr ; 79(1): 44-50, Jan. 2021. tab, graf
Article in English | LILACS | ID: biblio-1153141


ABSTRACT Background: Multiple sclerosis (MS) is an immune-mediated disease that affects the central nervous system. The impact of MS transcends physical functions and extends to psychological impairment. Approximately 50% of people with MS develop depressive symptoms during their lifetime and depressive symptoms may predict impairment of physical functions. However, prediction of depressive symptoms based on objective measures of physical functions is still necessary. Objective: To compare physical functions between people with MS presenting depressive symptoms or not and to identify predictors of depressive symptoms using objective measures of physical functions. Methods: Cross-sectional study including 26 people with MS. Anxiety and/or depressive symptoms were assessed by the Beck Depression Inventory-II (BDI-II) and by the Hospital Anxiety and Depression Scale (HADS). Outcomes of physical functions included: the Nnnine-hole Ppeg Ttest (NHPT), knee muscle strength, balance control, the Timed Up and Go Test (TUG), and the 6-minute walk test (6MWT). Perceived exertion was measured using the Borg scale. Results: The frequency of depressive symptoms was 42% in people with MS. Balance control during a more challenging task was impaired in people with MS who presented depressive symptoms. Balance could explain 21-24% of the variance in depressive symptoms. 6MWT and TUG presented a trend of significance explaining 16% of the variance in the BDI-II score. Conclusions: Impairment in physical functions consists in a potential predictor of depressive symptoms in people with MS. Exercise interventions aiming at the improvement of physical functions, together with the treatment of depressive symptoms and conventional medical treatment, are suggested.

RESUMO Introdução: A esclerose múltipla (EM) é uma doença imunomediada que afeta o sistema nervoso central. O impacto da doença transcende as funções físicas e se estende a comprometimento psicológico. Aproximadamente 50% das pessoas com EM desenvolvem sintomas depressivos e estes podem predizer o comprometimento das funções físicas. No entanto, a previsão de sintomas depressivos com base em medidas objetivas das funções físicas ainda é necessária. Objetivos: Comparar funções físicas entre pessoas com EM que apresentam ou não sintomas depressivos e identificar preditores de sintomas depressivos usando medidas objetivas de funções físicas. Métodos: Estudo transversal incluindo 26 pessoas com EM. A ansiedade e/ou sintomas depressivos foram avaliadas pelo Inventário de Depressão de Beck-II (Beck Depression Inventory - BDI-II) e pela Escala Hospitalar de Ansiedade e Depressão. Os resultados das funções físicas incluíram: teste de PEG de nove buracos, força muscular do joelho, controle de equilíbrio, teste Timed Up and Go (TUG) e teste da caminhada de seis minutos (TC6M). A fadiga percebida foi medida usando a escala de Borg. Resultados: A frequência de sintomas depressivos na amostra foi de 42%. O controle do equilíbrio durante tarefa desafiadora foi prejudicado em pessoas com EM e sintomas depressivos. O equilíbrio pode explicar 21-24% da variação nos sintomas depressivos. O TC6M e o TUG apresentaram tendência de significância que explica 16% da variância no escore do BDI-II. Conclusões: O comprometimento das funções físicas é potencial preditor de sintomas depressivos em pessoas com EM. São sugeridas intervenções de exercícios físicos visando melhora das funções físicas, juntamente com o tratamento médico convencional e dos sintomas depressivos.

Humans , Depression/etiology , Multiple Sclerosis/complications , Time and Motion Studies , Cross-Sectional Studies , Postural Balance
Article in English | LILACS, BBO | ID: biblio-1289978


ABSTRACT OBJECTIVE To estimate the prevalence of clinical signs and symptoms of severe/extreme stress, anxiety, and depression, as well as their associated factors, among Brazilians during social distancing. METHODS This is a cross-sectional study conducted in April/May 2020 with 3,200 Brazilians over 18 years old. Respondents' sociodemographic and clinical data were collected using an online questionnaire, which also included the 21-item Depression, Anxiety and Stress Scale (DASS-21) to assess emotional symptoms. Unadjusted and adjusted prevalence ratios and their respective 95% confidence intervals were estimated using Poisson regression models with robust variance. RESULTS Our results show the prevalence of severe/extreme stress was 21.5%, anxiety 19.4%, and depression 21.5%. In the final model, sociodemographic, clinical, and Covid-19-related factors were associated with severe/extreme stress, anxiety, and depression in Brazilians during social distancing due to the Covid-19 pandemic. We found the main factors associated with severe/extreme depression to be young women, brown, single, not religious, sedentary, presenting reduced leisure activities, history of anxiety and depression, increased medication use, and Covid-19 symptoms. CONCLUSION This study may help develop and systematically plan measures aimed to prevent, early identify, and properly manage clinical signs and symptoms of stress, anxiety, and depression during the Covid-19 pandemic.

Humans , Female , Adolescent , Pandemics , COVID-19 , Anxiety/etiology , Anxiety/epidemiology , Stress, Psychological/etiology , Stress, Psychological/epidemiology , Brazil/epidemiology , Cross-Sectional Studies , Surveys and Questionnaires , Depression/etiology , Depression/epidemiology , Physical Distancing , SARS-CoV-2
Braz. j. med. biol. res ; 54(3): e10010, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153525


We aimed to conduct a meta-analysis to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with post-stroke depression (PSD). Six relevant electronic databases (PubMed, CENTRAL, Embase, Web of Science, CINAHL, and PsycINFO) were searched. Randomized controlled trials (RCTs) that compared rTMS with control condition for PSD were included. The mean change in depression symptom scores was defined as the primary efficacy outcome. Secondary outcomes included the remission rate of depression, stroke recovery, and cognitive function recovery. In total, 7 RCTs with 351 participants were included. At post-treatment, rTMS was significantly more effective than the control condition, with a standardized mean difference (SMD) of -1.15 (95%CI: -1.62 to -0.69; P<0.001, I2=71%) and remission with an odds ratio (OR) of 3.46 (95%CI: 1.68 to 7.12; P<0.001; I2=11%). As for stroke recovery, rTMS was also better than the control condition (SMD=-0.67, 95%CI: -1.02 to -0.32; P<0.001). However, no significant difference was found for cognitive function recovery between the two groups (SMD=4.07, 95%CI: -1.41 to 9.55; P=0.15). To explore the potential moderators for the primary outcome, a series of subgroup and sensitivity analyses were performed. The results implied that rTMS may be more effective in Asian samples than in North American samples (P=0.03). In conclusion, from the current evidence in this study, rTMS could be an effective treatment for patients with PSD. Further clinical studies with larger sample sizes and clearer subgroup definitions are needed to confirm these outcomes.

Humans , Stroke/complications , Transcranial Magnetic Stimulation , Randomized Controlled Trials as Topic , Treatment Outcome , Recovery of Function , Depression/etiology , Depression/therapy
Braz. j. med. biol. res ; 54(3): e10428, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153523


There is increasing evidence that neurofilament light chain (NF-L) can be considered as a biomarker for neuro-axonal damage. This polypeptide can be released into the cerebrospinal fluid (CSF) and the blood, where it can be quantified. The concentration of NF-L is elevated in patients with multiple sclerosis (MS) and psychiatric disorders. We aimed to investigate the NF-L levels in the CSF from treated MS patients and the relationship with depression or anxiety. The study involved three groups: control group (individuals without inflammation), the relapse-remitting multiple sclerosis (RRMS)-untreated group, and the RRMS-Fingo group (RRMS patients who were treated with fingolimod). MS disability was assessed by the Expanded Disability Status Scale, and depression and anxiety were evaluated by a neuropsychologist, using the Hospital Anxiety and Depression Scale, the Beck Depression Inventory-II, and the Beck Anxiety Inventory. Individual CSF samples were collected to measure NF-L levels. The results of the statistical analysis on levels of NF-L in the CSF of control subjects, RRMS-untreated patients, and RRMS-Fingo patients were significant. The relationship between depression and anxiety in RRMS-Fingo patients and NF-L levels was not statistically significant. In conclusion, MS events such as anxiety and depression appear to contribute to the onset of clinical relapses, subclinical cases, and neurodegeneration.

Humans , Anxiety Disorders/etiology , Depression/etiology , Multiple Sclerosis/complications , Intermediate Filaments , Biomarkers , Neurofilament Proteins
Acta otorrinolaringol. cir. cabeza cuello ; 49(2): 121-128, 2021. ILUS, TAB, GRAF
Article in Spanish | LILACS | ID: biblio-1253866


Introducción: la pandemia puede generar compromiso en la salud mental y los otorrinolaringólogos son los especialistas con mayor riesgo de exposición y contagio por SARS-CoV-2. Materiales y métodos: estudio de corte transversal en otorrinolaringólogos de Hispanoamérica, donde se evaluaron variables socioeconómico/demográficas y su asociación con las escalas PHQ-9 y GAD-7. Resultados: se estudiaron 256 otorrinolaringólogos de dieciséis países de Hispanoamérica. La escala PHQ-9 presentó una media de 5,45 (DE 4,22). La escala GAD-7 presentó una media de 4,55 (DE 3,457). La prevalencia de depresión mayor y ansiedad fue del 14,8 % y 7 %, respectivamente. En el análisis multivariado, los otorrinolaringólogos a los que se les ha realizado prueba con hisopado nasofaríngeo tienen una predicción significativa para presentar una puntuación alta en la escala PHQ-9 (coeficiente ß = 2,350; p=0.027). En la puntuación de la escala GAD-7, los individuos con mayor edad tienen una predicción significativa de menor puntuación en la escala (coeficiente ß = -0,144; p=0,002). Los otorrinolaringólogos con más años de experiencia (coeficiente ß = 0,909; p=0,037) y aquellos a los que les han realizado prueba de RT-PCR con hisopado nasofaríngeo para SARS-CoV-2 tienen una predicción significativa para presentar una puntuación alta en la escala GAD-7 (coeficiente ß = 2,370; p=0,027). Conclusión: en el transcurso de la pandemia, los otorrinolaringólogos de Hispanoamérica han presentado cambios drásticos de sus condiciones sociales y económicas y experimentado sus potenciales efectos en la salud mental. La exposición a al hisopado nasofaríngeo para el diagnóstico de COVID-19 fue la única variable independiente que se asoció con aumento de las puntuaciones en las escalas GAD-7 y PHQ-9.

Introduction: The COVID-19 pandemic could affect the mental health, especially to the health workforce directly exposed to the virus. ENT surgeons have one of the highest risks of exposure and infection by SARS-CoV-2. Methods: Cross-sectional study in otolaryngologists from Hispanoamerica. Socioeconomic and demographic variables were evaluated with the PHQ-9 and GAD-7 score. Results: 256 ENT surgeons from sixteen Hispanoamerican countries were studied. The PHQ-9 scale presented an average of 5.45 (SD 4.22). The GAD-7 score presented an average of 4.55 (SD 3.457). The prevalence of major depression and generalized anxiety disorders were 14.8 % and 7 %, respectively. In the multivariate analysis, the otolaryngologists who have been tested by nasopharyngeal swab have a significant prediction to present a higher score on the PHQ-9 score (coefficient ß = 2.350, p=0.027), while on the GAD-7 score, older individuals have a significant prediction of lower score (coefficient ß = -0.144, p=0.002). Otolaryngologists with more years of experience (coefficient ß = 0.909, p=0.037) and those who have undergone RT-PCR testing with nasopharyngeal swab have a significant prediction to present a higher GAD-7 (coefficient ß = 2.370, p = 0.027). Conclusion: During the pandemic, otolaryngologists in Hispanoamerica have presented drastic changes in their social and economic conditions, and their potential effects on mental health. Exposure to the nasopharyngeal swab test for the diagnosis of COVID-19 was the only independent variable that was associated with higher scores on GAD-7 and PHQ-9.

Humans , Male , Female , Adult , Middle Aged , Aged , Mental Health , Otolaryngologists/psychology , COVID-19/psychology , Anxiety/epidemiology , Socioeconomic Factors , Linear Models , Cross-Sectional Studies , Depression/etiology , Patient Health Questionnaire , COVID-19/epidemiology
Rev. latinoam. enferm. (Online) ; 29: e3480, 2021. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1341516


Objective: to investigate associations between depressive symptoms during pregnancy, low birth weight, and prematurity among women with low-risk pregnancies assisted in public Primary Health Care services. Method: prospective cohort with 193 pregnant women, using the Edinburgh Postnatal Depression Scale, telephone interviews, and medical records available in the health services. Associations of interest were obtained using the Cox regression model. Results: the participants were aged 24.9 years old (median) and had 11 years of schooling (median); 82.4% lived with their partners, and gestational age at the birth was 39 weeks (median). Twenty-five percent of the participants scored ≥13 on the Edinburgh scale. Depressive symptoms did not appear associated with low birth weight (RR=2.06; CI95%=0.56-7.61) or prematurity (RR=0.86; CI95%=0.24-3.09) in the adjusted analysis. However, premature labor increased the risk of low birth weight (RR=4.81; CI95%=1.01-23.0) and prematurity (RR=7.70; CI95%=2.50-23.7). Additionally, each week added to gestational age decreased the risk of low birth weight (RR=0.76; CI95%=0.61-0.95). Conclusion: the presence of depressive symptoms among women with low-risk pregnancies was not associated with low birth weight or prematurity.

Objetivo: investigar a associação entre sintomas depressivos na gestação, baixo peso ao nascer e prematuridade entre gestantes de baixo risco obstétrico, atendidas em serviços públicos de Atenção Primária à Saúde. Método: coorte prospectiva com 193 gestantes, mediante aplicação da Escala de Depressão Pós-natal de Edimburgo, entrevista telefônica e consulta aos prontuários dos serviços de saúde. As associações de interesse foram obtidas por regressão múltipla de Cox. Resultados: as participantes tinham idade mediana de 24,9 anos e escolaridade mediana de 11 anos; 82,4% viviam com companheiro e a idade gestacional mediana no parto foi 39 semanas. Auferiram escore ≥13 na Escala de Edimburgo 25,4% delas. Na análise ajustada, sintomas depressivos não se associaram ao baixo peso ao nascer (RR=2,06; IC95%=0,56-7,61) e à prematuridade (RR=0,86; IC95%=0,24-3,09). Secundariamente, identificouse que trabalho de parto prematuro aumentou o risco de baixo peso ao nascer (RR=4,81; IC95%=1,01-23,0) e de prematuridade (RR=7,70; IC95%=2,50-23,7). Além disso, cada semana a mais na idade gestacional diminuiu o risco de baixo peso ao nascer (RR=0,76; IC95%=0,61-0,95). Conclusão: a presença de sintomas depressivos entre gestantes de baixo risco obstétrico não se associou ao risco de baixo peso ao nascer e prematuridade.

Objetivo: investigar la asociación entre síntomas depresivos en la gestación con bajo peso al nacer y prematuridad entre embarazadas, de bajo riesgo obstétrico, atendidas en servicios públicos de Atención Primaria a la Salud. Método: cohorte prospectiva en 193 embarazadas, utilizando la Escala de Depresión Posparto de Edimburgo, por medio de entrevista telefónica y consulta en las fichas médicas de los servicios de salud. Las asociaciones de interés fueron obtenidas con la regresión múltiple de Cox. Resultados: las participantes tuvieron edad mediana de 24,9 años y escolaridad mediana de 11 años; 82,4% vivían con compañero y la edad gestacional mediana en el parto fue 39 semanas. 25,4% de las mujeres obtuvieron un puntaje ≥13, en la Escala de Edimburgo. En el análisis ajustado, los síntomas depresivos no se asociaron al bajo peso al nacer (RR=2,06; IC95%=0,56-7,61) y a la prematuridad (RR=0,86; IC95%=0,24-3,09). Secundariamente, se identificó que el trabajo de parto prematuro aumentó el riesgo de bajo peso al nacer (RR=4,81; IC95%=1,01-23,0) y de prematuridad (RR=7,70; IC95%=2,50-23,7). Además de eso, se encontró que cada semana a más en la edad gestacional disminuye el riesgo de bajo peso al nacer (RR=0,76; IC95%=0,61-0,95). Conclusión: la presencia de síntomas depresivos entre embarazadas de bajo riesgo obstétrico no se asoció al riesgo de bajo peso al nacer y a la prematuridad.

Humans , Pregnancy , Infant, Newborn , Adult , Primary Health Care , Birth Weight , Infant, Premature , Gestational Age , Depression, Postpartum , Depression/etiology , Depression/epidemiology , Obstetric Labor, Premature
Rev inf cient ; 100(5): 1-10, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1348798


Introducción: A partir del rebrote de COVID-19 que desde el mes de noviembre de 2020 experimentó la nación, el grupo temporal para el enfrentamiento a la epidemia abrió nuevos centros de aislamiento con el objetivo principal de brindar atención médica integral y de enfermería a pacientes que han sido contacto de personas contagiadas con esta enfermedad. Objetivo: Identificar las alteraciones psicológicas más frecuentes experimentadas por médicos, personal de enfermería y estudiantes de Medicina en el centro de aislamiento ubicado en la Facultad de Medicina No. 2 de Santiago de Cuba. Método: Se realizó un estudio descriptivo a 150 trabajadores de la zona roja de este centro de aislamiento en el periodo comprendido desde el 1 de marzo al 31 de mayo de 2021, para lo cual se empleó una metodología mixta, con una estrategia de triangulación de datos en un sentido cuanticualitativo. Resultados: La alteración psicológica de la esfera afectiva que predominó en estos trabajadores fue la ansiedad con un 98 porciento entre los médicos y enfermeros y un 100 porciento entre los estudiantes. En cuanto a la esfera cognitiva se destacó la presencia de imágenes intrusivas en el 72 porciento de los médicos, el 68 porciento del personal de enfermería y el 54 porciento de los estudiantes. Mientras que en la esfera volitiva predominó la incomodidad por el uso de los medios de protección en el 100 porciento de los sujetos encuestados. Conclusiones: En el centro de aislamiento estudiado, se identifican alteraciones psicológicas en el personal médico, de enfermería y estudiantes de Medicina. Destacan como las más frecuentes: la ansiedad, el estrés, imágenes intrusivas, dificultad para concentrase, el consumo de sustancias lícitas y trastornos del sueño(AU).

Introduction: Since the outbreak of COVID-19 that the nation experienced in November 2020, the temporary group to confront the epidemic opened new COVID-19 quarantine facilities with the main objective of providing comprehensive medical and nursing care to patients who have been in contact with people infected with this disease. Objective: To identify the most frequent psychological alterations experienced by doctors, nursing staff and medical students in the isolation facilities located at the Faculty of Medicine No. 2 of Santiago de Cuba. Method: A descriptive study was carried out on 150 workers in the red zone of this facility in the period from March 1st to May 31st, 2021, for which a mixed methodology was used, with a data triangulation strategy in a quantitative sense. Results: The psychological alteration of the affective sphere that predominated in these workers was anxiety, with 98 percent among doctors and nurses and 100 percent among students. Regarding the cognitive sphere, the presence of intrusive images stood out in 72 percent of the doctors, 68 percent of the nursing staff and 54 percent of the students. While in the volitional sphere, discomfort due to the use of means of protection prevailed in 100 percent of the subjects surveyed. Conclusions: In the quarantine center studied, psychological alterations were identified in the medical staff, nursing staff and medical students. The most frequent ones that stand out were: anxiety, stress, intrusive images, difficulty concentrating, the use of legal substances and sleep disorders(AU).

Introdução: A partir do surto de COVID-19 que viveu o país desde novembro de 2020, o grupo temporário de enfrentamento à epidemia inaugurou novos centros de isolamento com o objetivo principal de prestar assistência médica e de enfermagem integral aos pacientes que estiveram em contato com pessoas infectadas com esta doença. Objetivo: Identificar as alterações psicológicas mais frequentes vivenciadas por médicos, enfermeiras e estudantes de Medicina no centro de isolamento localizado na Facultad de Medicina Nº 2 de Santiago de Cuba. Método: Foi realizado um estudo descritivo com 150 trabalhadores da zona vermelha deste centros de isolamento no período de 1º de março a 31 de maio de 2021, para o qual foi utilizada uma metodologia mista, com estratégia de triangulação de dados no sentido quantitativo. Resultados: A alteração psicológica da esfera afetiva que predominou nesses trabalhadores foi a ansiedade com 98 porcento entre médicos e enfermeiras e 100 porcento entre estudantes. Em relação à esfera cognitiva, a presença de imagens intrusivas destacou-se em 72 porcento dos médicos, 68 porcento da equipe de enfermagem e 54 porcento dos alunos. Já na esfera volitiva, o desconforto devido ao uso de meios de proteção prevaleceu em 100 porcento dos sujeitos pesquisados. Conclusões: No isolamento estudado, foram identificadas alterações psicológicas na equipe médica, equipe de enfermagem e estudantes de Medicina. Destacam-se os mais frequentes: ansiedade, estresse, imagens intrusivas, dificuldade de concentração, uso de substâncias lícitas e distúrbios do sono(AU).

Humans , Adult , Middle Aged , Stress, Psychological/etiology , Burnout, Professional , Health Personnel/psychology , Depression/etiology , Performance Anxiety , Epidemiology, Descriptive , Hospitals, Isolation
Article in Chinese | WPRIM | ID: wpr-921811


The present study investigated the effects and mechanisms of Jiaotai Pills on depressed mice induced by chronic unpredictable mild stress(CUMS). The CUMS-induced depression model mice were established and the depression behaviors of mice were evaluated by sucrose preference test, open field test, tail suspension test, and forced swimming test. Molecular docking was employed to simulate the interaction of six main active ingredients in Jiaotai Pills with SIRT1. Immunohistochemical staining was used to detect the level of SIRT1 in the hippocampus of mice. Western blot was used to detect the protein expression levels of SIRT1, p-NF-κB p65, NF-κB p65, and FoxO1 in the hippocampus of mice. Enzyme-linked immunosorbent assay(ELISA) kits were used to detect the levels of interleukin(IL)-1β, IL-6, tumor necrosis factor-α(TNF-α), and brain-derived neurotrophic factor(BDNF) in the hippocampus and serum of mice. Biochemical kits were used to detect superoxide dismutase(SOD) activity and malondialdehyde(MDA) and glutathione(GSH) levels in the hippocampus and serum of mice. Liquid chromatography-tandem mass spectrometry(LC-MS/MS) was used to detect the levels of dopamine(DA), 5-hydroxytryptamine(5-HT), and norepinephrine(NE) in the hippocampus and serum of mice. The results showed that the sucrose preference rate, movement distance, and the number of crossing centers were reduced in the model group(P<0.01), and the tail suspension time and swimming immobility time were increased(P<0.01). Molecular docking results indicated good binding of six main active ingredients in Jiaotai Pills to SIRT1. In the hippocampus, the expression level of SIRT1 was reduced(P<0.01), and the levels of p-NF-κB p65/NF-κB p65 and FoxO1 were increased(P<0.01). In the hippocampus and serum, the levels of IL-1β, IL-6, TNF-α, and MDA were increased(P<0.01), and the activity of SOD and the levels of GSH, DA, 5-HT, NE, and BDNF were reduced(P<0.01). The treatment with high-dose Jiaotai Pills increased the sucrose preference rate, movement distance, and the number of crossing centers(P<0.05), reduced tail suspension time and swimming immobility time(P<0.01), elevated hippocampal SIRT1 expression level(P<0.01), decreased hippocampal and serum IL-1β, IL-6, TNF-α, and MDA levels(P<0.01), potentiated SOD activity, and up-regulated GSH, DA, 5-HT, NE, and BDNF levels in the hippocampus and serum(P<0.05, P<0.01) in model mice. In conclusion, the results showed that Jiaotai Pills could improve the depression behaviors of model mice with CUMS-induced depression, and the underlying mechanism was related to the up-regulation of SIRT1 in the hippocampus of mice to exert anti-inflammatory and anti-oxidative stress effects.

Animals , Antidepressive Agents , Behavior, Animal , Chromatography, Liquid , Depression/etiology , Disease Models, Animal , Drugs, Chinese Herbal , Hippocampus , Mice , Molecular Docking Simulation , Sirtuin 1/genetics , Stress, Psychological , Tandem Mass Spectrometry
Article in English | WPRIM | ID: wpr-888495


To investigate the intestinal amino acids pathway in depression-like offspring rats induced by maternal separation. Sprague-Dawley (SD) female rats were randomly divided into a control group (=8) and a maternal separation group (=8). After normal delivery, the maternal rats were separated from offsprings for 14 consecutive days and 3 h per day in maternal separation group; while rats in the control group was received no interventions in postpartum. Depression-like behaviors of offspring rats were evaluated using the sucrose preference test, novelty suppressed feeding test, and forced swimming test. Amino acid analyzer was used to detect the changes of amino acid contents in the small intestine, and the expressions of alanine-serine-cysteine transporter 2 (ASCT2), solute carrier superfamily 6 member 19 (BAT1) and L-type amino acid transporter 1(LAT1) were detected by Western blot. The weight of the offspring rats in the maternal separation group was significantly lower than that of the control group at 21 and 28 d (=4.925 and 5.766, all <0.01). Compared with the control group, the percentage of sucrose preference of the offspring rats in the maternal separation group was significantly reduced (=2.709, <0.05), and the feeding latency was significantly prolonged (=-13.431, <0.01). The immobility time in FST of maternal separation group was significantly longer (=-3.616, <0.01).Increased concentration of aspartic acid (=-6.672, <0.01) and down-regulation of glutamine (=3.107, <0.01) and glycine (=9.781, <0.01) were observed in maternal separation group. Western blot analysis revealed that the protein expressions of ASCT2 (=6.734, <0.01) and BAT1 (=9.015, <0.01) in maternal separation group were reduced, while the expression of LAT1 was increased (=-8.942, <0.01). Maternal separation can induce the depression-like behavior in offspring rats; the amino acid contents and the amino acid transporter expression in the small intestine are reduced, which may be related to depression-like behavior induced by maternal separation.

Amino Acids , Animals , Depression/etiology , Female , Hippocampus , Maternal Deprivation , Rats , Rats, Sprague-Dawley
Article in English | WPRIM | ID: wpr-877761


INTRODUCTION@#Frontline healthcare workers (HCWs) exposed to coronavirus disease 2019 (COVID-19) are at risk of psychological distress. This study evaluates the psychological impact of COVID-19 pandemic on HCWs in a national paediatric referral centre.@*METHODS@#This was a survey-based study that collected demographic, work environment and mental health data from paediatric HCWs in the emergency, intensive care and infectious disease units. Psychological impact was measured using the Depression, Anxiety, Stress Scale-21. Multivariate regression analysis was performed to identify risk factors associated with psychological distress.@*RESULTS@#The survey achieved a response rate of 93.9% (430 of 458). Of the 430 respondents, symptoms of depression, anxiety and stress were reported in 168 (39.1%), 205 (47.7%) and 106 (24.7%), respectively. Depression was reported in the mild (47, 10.9%), moderate (76, 17.7%), severe (23, 5.3%) and extremely severe (22, 5.1%) categories. Anxiety (205, 47.7%) and stress (106, 24.7%) were reported in the mild category only. Collectively, regression analysis identified female sex, a perceived lack of choice in work scope/environment, lack of protection from COVID-19, lack of access to physical activities and rest, the need to perform additional tasks, and the experience of stigma from the community as risk factors for poor psychological outcome.@*CONCLUSION@#A high prevalence of depression, anxiety and stress was reported among frontline paediatric HCWs during the COVID-19 pandemic. Personal psychoneuroimmunity and organisational prevention measures can be implemented to lessen psychiatric symptoms. At the national level, involving mental health professionals to plan and coordinate psychological intervention for the country should be considered.

Adult , Anxiety/etiology , COVID-19/psychology , Depression/etiology , Female , Health Surveys , Hospitals, Pediatric , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Occupational Diseases/etiology , Pandemics , Personnel, Hospital/psychology , Prevalence , Risk Factors , Self Report , Severity of Illness Index , Singapore/epidemiology , Stress, Psychological/etiology
Article in English | WPRIM | ID: wpr-922201


BACKGROUND@#The 2019 novel coronavirus disease (COVID-19) emerges in China, which spreads rapidly and becomes a public health emergency of international concern. Chinese government has promptly taken quarantine measures to block the transmission of the COVID-19, which may cause deleterious consequences on everyone's behaviors and psychological health. Few studies have examined the associations between behavioral and mental health in different endemic areas. This study aimed to describe screen time (ST), physical activity (PA), and depressive symptoms, as well as their associations among Chinese college students according to different epidemic areas.@*METHODS@#The study design is cross-sectional using online survey, from 4 to 12 February 2020, 14,789 college students accomplished this online study, participants who did not complete the questionnaire were excluded, and finally this study included 11,787 college students from China.@*RESULTS@#The average age of participants was 20.51 ± 1.88 years. 57.1% of the college students were male. In total, 25.9% of college students reported depression symptoms. ST > 4 h/day was positively correlated with depressive symptoms (β = 0.48, 95%CI 0.37-0.59). COVID-19ST > 1 h/day was positively correlated with depressive symptoms (β = 0.54, 95%CI 0.43-0.65), compared with COVID-19ST ≤ 0.5 h/day. Compared with PA ≥ 3 day/week, PA < 3 day/week was positively associated with depression symptoms (β = 0.01, 95%CI 0.008-0.012). Compared with low ST and high PA, there was an interaction association between high ST and low PA on depression (β = 0.31, 95%CI 0.26-0.36). Compared with low COVID-19ST and high PA, there was an interaction association between high COVID-19ST and low PA on depression (β = 0.37, 95%CI 0.32-0.43). There were also current residence areas differences.@*CONCLUSIONS@#Our findings identified that high ST or low PA was positively associated with depressive symptoms independently, and there was also an interactive effect between ST and PA on depressive symptoms.

Adult , COVID-19/psychology , China/epidemiology , Cross-Sectional Studies , Depression/etiology , Exercise , Female , Humans , Male , Mental Health/statistics & numerical data , Screen Time , Students/psychology , Time Factors , Universities , Young Adult
Article in English | LILACS, BBO | ID: biblio-1287501


Abstract Objective: To evaluate the effect of the COVID-19 pandemic on senior undergraduate dental students' psychological health by measuring depression, anxiety, and stress levels. Material and Methods: 259 fifth-year dental students participated in this study, including 156 females (60.2%) and 103 males (39.8%), aged 20-25. An online-based questionnaire was created, including a few questions about learning, post-graduation challenges, and fear of the virus exposure. Students were asked to define their acute anxiety state by visual facial anxiety scale (VFAS) and depression, anxiety, and stress levels by The Depression, Anxiety and Stress Scale (DASS-42). All data were analyzed statistically. Results: Participants stated online learning platforms were insufficient for clinical competence (91.5%), the COVID-19 pandemic changed post-graduation career perspectives (29.3%), and they feared exposure to COVID-19 while performing their profession (82.6%). Acute anxiety levels of the students were recorded as 95.4% mild to highest. Mild to extremely severe depression, anxiety, and stress scores of the participants were 82.1%, 79.6%, and 72.9%, respectively. Higher mean values for all depression, anxiety, and stress parameters were obtained in females than males (p<0.05). Conclusion: Data showed that the psychological health of senior undergraduate dental students had been affected adversely due to the COVID-19 pandemic.

Humans , Male , Female , Adult , Anxiety/etiology , Anxiety/epidemiology , Students, Dental , Mental Health , Depression/etiology , Depression/epidemiology , COVID-19/psychology , Turkey/epidemiology , Surveys and Questionnaires , Data Interpretation, Statistical
Psicol. USP ; 32: e200003, 2021. tab
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1287649


Resumo A depressão tem alcançado níveis epidêmicos ao redor do mundo. Seria a depressão um distúrbio mental, como é consenso na saúde mental? Teóricos evolucionistas têm-se questionado quanto à função da depressão e proposto modelos específicos para explicá-la. O objetivo deste artigo é apresentar teorias evolucionistas da depressão, discutir as relações de complementariedade e contraposição entre elas e as implicações sociais e práticas para o tratamento da depressão. Essas reflexões e questionamentos no domínio da saúde mental podem influenciar novos estudos a partir de uma perspectiva não patológica da depressão. No âmbito da psicologia essa perspectiva fornece subsídios para repensar a psicoterapia com o deprimido, enfocando a análise causal e a resolução de problemas. Sugere-se a realização de estudos empíricos com a finalidade de testar e sistematizar as teorias evolucionistas da depressão.

Resumen La depresión ha alcanzado niveles epidemiológicos alrededor del mundo. ¿Será la depresión un trastorno mental como se cree en el dominio de la salud mental? Teóricos evolucionistas se cuestionan sobre la depresión y han propuesto modelos específicos para explicarla. El objetivo de este artículo fue presentar teorías evolutivas de la depresión, discutir las relaciones de complementariedad y contraposición entre ellas, así como las implicaciones sociales y prácticas para su tratamiento. Estas reflexiones y cuestionamientos, en el dominio de la salud mental, pueden influir en nuevos estudios a partir de una perspectiva no patológica de la depresión. En el ámbito de la psicología, esta perspectiva provee subsidios para repensar la psicoterapia con el deprimido enfocándose en el análisis causal y la resolución de problemas. Se sugiere la realización de estudios empíricos con la finalidad de probar y sistematizar las teorías evolucionistas de la depresión.

Résumé La dépression a atteint les proportions d'une épidémie mondiale. Les théoriciens évolutionnistes se sont interrogés sur la fonction de la dépression et ont proposé des modèles spécifiques pour l'expliquer. Cet article vise à présenter les différentes théories évolutionnistes de la dépression, discuter leurs relations de complémentarité et d'opposition, et débattre les possibles implications sociales et pratiques pour le traitement de la dépression. Ces réflexions dans le domaine de la santé mentale peuvent influencer de nouvelles études dans une perspective non pathologique de la dépression. Dans le domaine de la psychologie, cette perspective permet de repenser la psychothérapie avec les personnes déprimées, en se concentrant sur l'analyse causale et la résolution des problèmes. Des études empiriques sont proposées dans le but de tester et systématiser les théories évolutionnistes de la dépression.

Abstract Depression has reached epidemic levels worldwide. Would that be a mental disorder, as claimed by consensus on mental health? Evolutionary theorists have questioned the function of depression and proposed specific models to explain it. The aim of this paper is to present the evolutionary theories of depression, to discuss the complementarity and contradictions between these theories, and to present the social and practical implications for the treatment of depression. Those reflections and issues in the field of mental health may influence further studies from a non-pathological perspective of depression. In the field of psychology, this perspective provides insights to reevaluate psychotherapy to treat depression by focusing on causal analysis and problem solving. The study suggests that new empirical studies should be conducted to test and systematize evolutionary theories of depression.

Selection, Genetic , Cost of Illness , Depression/etiology , Depression/psychology , Mental Health , Adaptation
Arch. endocrinol. metab. (Online) ; 65(5): 537-548, 2021. graf
Article in English | LILACS | ID: biblio-1345195


ABSTRACT Objective: Obesity is characterized by a state of chronic, low-intensity systemic inflammation frequently associated with insulin resistance and dyslipidemia. Materials and methods: Given that chronic inflammation has been implicated in the pathogenesis of mood disorders, we investigated if chronic obesity that was initiated early in life - lasting through adulthood - could be more harmful to memory impairment and mood fluctuations such as depression. Results: Here we show that pre-pubertal male rats (30 days old) treated with a high-fat diet (40%) for 8-months gained ~50% more weight when compared to controls, exhibited depression and anxiety-like behaviors but no memory impairment. The prefrontal cortex of the obese rats exhibited an increase in the expression of genes related to inflammatory response, such as NFKb, MMP9, CCl2, PPARb, and PPARg. There were no alterations in genes known to be related to depression. Conclusion: Long-lasting obesity with onset in prepuberal age led to depression and neuroinflammation but not to memory impairment.

Animals , Male , Rats , Behavior, Animal , Depression/etiology , Anxiety , Diet, High-Fat/adverse effects , Obesity
Int. braz. j. urol ; 46(6): 993-1005, Nov.-Dec. 2020. tab
Article in English | LILACS | ID: biblio-1134264


ABSTRACT Purpose To investigate the course of anxiety and depression before and after transrectal ultrasound-guided prostate biopsy (TRUS-Bx) and in the postoperative 1st month when the histopathological biopsy result was obtained. Methods In between June 2017- January 2019, 204 patients who underwent TRUS-Bx and completed the questionnaires assessing anxiety and depression were included in the study. Questionnaires were completed immediately before the biopsy, immediately after the biopsy and at the end of the first month when the histopathological biopsy results were given. State-Trait Anxiety Inventory (STAI), Hospital Anxiety and Depression Scale (HADS) and perceived stress scale (PSS) forms were used to assess anxiety and depression. After the histopathological examination patients were divided into two groups as patients without cancer (Group 1) and with cancer (Group 2). Data was compared between the groups. Results PSA level was negatively correlated with STAI TX-1 scores of the patients immediately after TRUS-Bx, whereas it was positively correlated with STAI TX-1 and TX-2 30 days after the TRUS-Bx. PSA level was positively correlated with HADS-A and HADS-D scores immediately before and 30 days after TRUS-Bx. Biopsy results showed a significant difference in 30 day post-biopsy related data. STAI TX-1, STAI TX-2, HADS-A, HADS-D and PSS scores were higher in Group 2 compared with Group 1. Conclusions Pre-biopsy anxiety disappeared after bx, but there was a significant increase in anxiety and depression in patients after the diagnosis of malignancy. Patients were seriously concerned about the diagnosis of prostate cancer.

Humans , Male , Aged , Prostatic Neoplasms , Depression/etiology , Anxiety/etiology , Biopsy , Prospective Studies , Prostate-Specific Antigen , Ultrasonography, Interventional , Image-Guided Biopsy , Middle Aged
Arq. bras. cardiol ; 115(3): 462-467, out. 2020. tab
Article in English, Portuguese | SES-SP, LILACS, SES-SP | ID: biblio-1131319


Resumo Fundamento O Diabetes Mellitus Tipo 2 (DMT2) é comum nos idosos, que também apresentam um nível elevado de fatores de risco para doenças cardiovasculares (DCVs), tais como dislipidemia. Entretanto, o papel da depressão nos pacientes com DMT2 e sua relação com fatores de risco para DCV são pouco estudados. Objetivo O objetivo do presente estudo foi investigar a relação entre sintomas depressivos (SDs) e fatores de risco cardiovascular conhecidos em idosos comunitários portadores de DMT2. Métodos Trata-se de um estudo transversal, no qual foram incluídos 85 idosos comunitários com DMT2. Os SDs foram avaliados através da Escala de Depressão Geriátrica de Yesavage, em versão reduzida (GDS-15). Os seguintes fatores de risco cardiovascular foram avaliados: pressão arterial sistólica (PAS) e diastólica (PAD), glicose plasmática em jejum (GPJ), perfil lipídico (triglicerídeos séricos (TG), colesterol total sérico (CT), colesterol sérico de lipoproteína de baixa densidade (LDL-C) e colesterol sérico de lipoproteína de baixa densidade (HDL-C)) e índice de massa corporal (IMC). A análise de regressão múltipla de Poisson foi utilizada para avaliar a associação entre os SDs e cada fator de risco cardiovascular ajustado por sexo, idade, tempo em atividades físicas moderadas e status funcional. O nível de significância adotado para a análise foi de 5%. Resultados Dentre todos os fatores de risco analisados, apenas o aumento de LDL-C apresentou uma correlação com níveis elevados de SD (RP=1,005; IC95% 1,002-1,008). Foi observada uma associação significativa entre os níveis de HDL-C (RP=0,99; IC95% 0,98-0,99) e a PAS (RP=1,009; IC95% 1,004-1,014). Conclusão Nos idosos com DMT2, a presença de SD foi associada a níveis de LDL-C, HDL-C e PAS, mesmo após o ajuste por sexo, idade, nível de atividade física e capacidade funcional. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)

Abstract Background Type 2 Diabetes Mellitus (T2DM) is common in older adults, who also present a high level of risk factors for cardiovascular disease (CVD), such as dyslipidemia. However, the role of depression in T2DM patients and its relationship with CVD risk factors are understudied. Objective The present study aimed to investigate the relationship between depressive symptoms (DS) and known cardiovascular risk factors in community dwelling older adults with T2DM. Methods This is a cross sectional study, in which 85 community-dwelling older adults with T2DM were assessed. DS was assessed using the Yesavage Geriatric Depression Scale - short version (GDS-15). The following cardiovascular risk factors were evaluated: systolic (SBP) and diastolic blood pressure (DBP), fasting plasma glucose (FPG), lipid profile (serum triglycerides - TG, serum total cholesterol - TC, serum low-density lipoprotein cholesterol - LDL-C, and serum high-density lipoprotein cholesterol - HDL-C) and body mass index (BMI). Poisson multiple regression was performed to test the association between DS and each cardiovascular risk factor adjusted by sex, age, time spent in moderate physical activity, and functional status. The significance level adopted for the analysis was 5%. Results Among all the analyzed risk factors, only high levels of LDL-C were related to high DS (PR=1.005, CI 95% 1.002-1.008). A significant association was observed between HDL-C levels (PR=0.99, CI 95% 0.98-0.99) and SBP (PR=1.009, CI 95% 1.004-1.014). Conclusion In older adults with T2DM, the presence of DS was associated with LDL-C, HDL-C levels and SBP, even after adjusting for sex, age, physical activity level and functional capacity. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)

Humans , Aged , Depression/etiology , Diabetes Mellitus, Type 2/complications , Triglycerides , Cross-Sectional Studies , Risk Factors , Cholesterol, HDL , Cholesterol, LDL