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1.
An. bras. dermatol ; 94(6): 744-746, Nov.-Dec. 2019. graf
Article in English | LILACS | ID: biblio-1054899

ABSTRACT

Abstract This report describes a case of unusual deep skin ulcers with tortuous sinus tract formation in an immunocompetent woman. She was initially diagnosed with a Staphylococcus aureus skin infection and histopathologically diagnosed with pyoderma gangrenosum. However, culture from the deep end of ribbon gauze inserted into the subcutaneous sinus tract revealed shiny, light-yellow mucoid colonies, which were identified as Cryptococcus neoformans var. grubii. She was treated with fluconazole for nine months and completely healed. Cryptococcosis is an opportunistic infection caused by variants of C. neoformans species. Cutaneous manifestations of cryptococcosis are quite divergent, rarely occurring as deep skin ulcers with sinus formation.


Subject(s)
Humans , Female , Adult , Skin Ulcer/microbiology , Skin Ulcer/pathology , Cryptococcosis/pathology , Cryptococcus neoformans/isolation & purification , Dermatomycoses/pathology , Immunocompetence , Skin Ulcer/drug therapy , Fluconazole/therapeutic use , Immunocompromised Host , Cryptococcosis/microbiology , Cryptococcosis/drug therapy , Dermatomycoses/microbiology , Dermatomycoses/drug therapy , Antifungal Agents/therapeutic use
2.
Rev. Soc. Bras. Med. Trop ; 52: e20180480, 2019. tab, graf
Article in English | LILACS | ID: biblio-1013305

ABSTRACT

Abstract We report a rare case of subcutaneous phaeohyphomycosis caused by Cladophialophora bantiana in an immunocompetent patient in Amazonas, Brazil. This dematiaceous fungus has been mainly associated with life-threatening infections affecting the central nervous systems of immunosuppressed patients. We present the clinical, laboratory, and therapeutic aspects, and in vitro susceptibility test results for different antifungal drugs. A brief review of the cases reported in the literature over the past 20 years has also been discussed. According to the literature review, the present case is the first report of subcutaneous phaeohyphomycosis due to C. bantiana in an immunocompetent patient in Latin America.


Subject(s)
Humans , Male , Ascomycota/isolation & purification , Phaeohyphomycosis , Phaeohyphomycosis/diagnosis , Biopsy , Brazil , Immunocompromised Host , Dermatomycoses/drug therapy , Mitosporic Fungi/isolation & purification , Phaeohyphomycosis/immunology , Phaeohyphomycosis/drug therapy , Middle Aged , Antifungal Agents/classification , Antifungal Agents/therapeutic use
3.
Bol. micol. (Valparaiso En linea) ; 33(1): 21-25, jun. 2018. ilus
Article in Spanish | LILACS | ID: biblio-904996

ABSTRACT

Se presenta un caso de dermatitis facial por Malassezia pachydermatis en un paciente de 34 años de edad, diagnosticado mediante clínica y estudio micológico. M. pachydermatis es una levadura que forma parte de la microbiota de mamíferos domésticos y animales salvajes, donde frecuentemente puede provocar dermatitis y otitis externa. En humanos, son escasas las infecciones por este agente, describiéndose desde infecciones superficiales hasta fungemias. En Chile se la ha encontrado como agente causal de pitiriasis versicolor y dermatitis seborreica principalmente en pacientes inmunocomprometidos.


We present a clinical case of facial dermatitis due to Malassezia pachydermatis in a patient of 34 years old, diagnosed by clinical and micology study. M. pachydermatis is a zoofilic yeast that is part of the microbiota of domestic mammals and wild animals, frequently causing dermatitis and external otitis. In humans, infections by this agent are very scarce, describing from superficial infections to fungemias. In Chile it has been found as causal agent of pitiriasis versicolor and seborrheic dermatitis mainly in inmunocompromised patients.


Subject(s)
Humans , Male , Adult , Dermatomycoses/drug therapy , Face/microbiology , Malassezia/isolation & purification , Malassezia/pathogenicity , Chile , Dermatomycoses/diagnosis , Mitosporic Fungi
4.
An. bras. dermatol ; 93(1): 141-142, Jan.-Feb. 2018. graf
Article in English | LILACS | ID: biblio-887158

ABSTRACT

Abstract: Dermatophytes are fungi capable of invading keratinized tissues. Isolation of the fungus with the culture is essential to guide the treatment, because there are more resistant species like Microsporum canis. The chronic use of corticosteroids leads to the deregulation of immunity, promoting atypical manifestations of infections. Topical antifungal therapy is often insufficient, requiring systemic medications. We describe the case of a patient undergoing systemic corticosteroid therapy with a large figurate lesion who presented complete response to exclusively topical treatment.


Subject(s)
Humans , Female , Adult , Immunocompromised Host , Dermatomycoses/drug therapy , Erythema/drug therapy , Miconazole/analogs & derivatives , Antifungal Agents/therapeutic use , Administration, Cutaneous , Dermatomycoses/microbiology , Erythema/microbiology , Miconazole/therapeutic use , Microsporum/isolation & purification
5.
Rev. chil. infectol ; 34(6): 613-614, dic. 2017. graf
Article in Spanish | LILACS | ID: biblio-1042642

ABSTRACT

The dermatological manifestations of disseminated histoplasmosis present in about 17% of the cases, is a challenge for its diagnosis. We report the case of a patient from the northern coast of Peru, who presented diffuse dermal lesions, erythema-violaceous nodules, and ulcers histopathologically compatible with the infection of the genus Histoplasma var. capsulatum


Subject(s)
Humans , Male , Middle Aged , Dermatomycoses/pathology , Histoplasmosis/pathology , Peru , Biopsy , Treatment Outcome , Dermatomycoses/drug therapy , Histoplasma/isolation & purification , Histoplasmosis/drug therapy , Antifungal Agents/therapeutic use
6.
An. bras. dermatol ; 92(3): 304-311, May-June 2017. tab, graf
Article in English | LILACS | ID: biblio-886949

ABSTRACT

Abstract Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described. It is an invasive life-threatening disease and in order to improve survival, a prompt diagnosis and multidisciplinary management should be provided. The treatment of choice is amphotericin B, but new azoles, such as posaconazole and isavuconazole, must be considered.


Subject(s)
Humans , Dermatomycoses , Mucormycosis , Dermatomycoses/diagnosis , Dermatomycoses/microbiology , Dermatomycoses/drug therapy , Dermatomycoses/epidemiology , Mucormycosis/diagnosis , Mucormycosis/microbiology , Mucormycosis/drug therapy , Mucormycosis/epidemiology , Antifungal Agents/therapeutic use
7.
Rev. Soc. Bras. Med. Trop ; 50(2): 277-279, Mar.-Apr. 2017. graf
Article in English | LILACS | ID: biblio-842840

ABSTRACT

Abstract Botryomycosis is an uncommon, chronic, suppurative, bacterial infection that primarily affects the skin and subcutaneous tissues. It has long been associated with defects of cellular immunity. We report a 28-year-old woman who presented with a chronic, ulcerated lesion with draining sinuses in the right malar region. Predisposing factors were HIV infection with poor immunological control, alcoholism, and a previous trauma to the right cheek. Several courses of antimicrobial therapy provided only partial and temporary remission. Complete clinical remission was only achieved 5 years later when a novel antiretroviral regimen composed of darunavir and raltegravir was initiated.


Subject(s)
Humans , Female , Adult , Pyoderma/drug therapy , AIDS-Related Opportunistic Infections/drug therapy , Botrytis/isolation & purification , Dermatomycoses/drug therapy , Facial Dermatoses/drug therapy , Pyoderma/diagnosis , AIDS-Related Opportunistic Infections/diagnosis , Anti-HIV Agents/therapeutic use , Dermatomycoses/diagnosis , Facial Dermatoses/diagnosis , Darunavir/therapeutic use , Raltegravir Potassium/therapeutic use
8.
An. bras. dermatol ; 92(5,supl.1): 69-72, 2017. tab, graf
Article in English | LILACS | ID: biblio-887091

ABSTRACT

Abstract Cryptococcosis is a common fungal infection in immunocompromised patients, caused by genus Cryptococcus, presenting with meningitis, pneumonia, and skin lesions. Cutaneous presentation can be varied, but specifically in solid organ transplant recipients (iatrogenically immunocompromised), cryptococcosis should always be considered in the differential diagnosis of cellulitis-like lesions, since the delay in diagnosis leads to worse prognosis and fatal outcome. We report four cases of cryptococcosis with cutaneous manifestation not only for its rarity, but also to emphasize the important role of the dermatologist in the diagnosis of this disease.


Subject(s)
Humans , Male , Adult , Middle Aged , Cryptococcosis/pathology , Dermatomycoses/pathology , Skin/pathology , Biopsy , Cryptococcosis/immunology , Cryptococcosis/drug therapy , Dermatomycoses/immunology , Dermatomycoses/drug therapy , Diagnosis, Differential , Immunocompetence , Antifungal Agents/therapeutic use
9.
An. bras. dermatol ; 91(6): 832-834, Nov.-Dec. 2016. graf
Article in English | LILACS | ID: biblio-837990

ABSTRACT

Abstract Cryptococcosis is a fungal infection of opportunistic behavior that is unusual in immunocompetent patients. We report a rare case of disseminated cryptococcosis with cutaneous involvement in an immunocompetent individual. During hospitalization, Cryptococcus gattii was isolated from skin lesions, lung and spinal fluid. The diagnosis of disseminated cryptococcosis was confirmed and treatment was established. The patient showed improvement. Due to the probable clinical severity of the disease and the possibility that skin lesions may be the first manifestation of this illness, prompt diagnosis must be established and treatment provided.


Subject(s)
Humans , Male , Adult , Cryptococcosis/immunology , Cryptococcosis/pathology , Dermatomycoses/immunology , Dermatomycoses/pathology , Cryptococcus gattii/isolation & purification , Immunocompetence , Skin/microbiology , Skin/pathology , Treatment Outcome , Cryptococcosis/drug therapy , Dermatomycoses/drug therapy , Lymphocytosis/complications , Lung/microbiology , Antifungal Agents/therapeutic use
11.
An. bras. dermatol ; 90(3): 438-439, May-Jun/2015.
Article in English | LILACS | ID: lil-749650
12.
An. bras. dermatol ; 90(2): 255-257, Mar-Apr/2015. graf
Article in English | LILACS | ID: lil-741072

ABSTRACT

A 70-year-old male presenting a 3-month history of genital painless erythematous nodules in the balanopreputial sulcus was referred to our service. Histopathological exam presented a chronic dermatitis with epithelioid granulomas and Grocott staining revealed numerous fungal structures with a suggestive morphology of Histoplasma sp. Cultures evidenced Histoplasma capsulatum var. capsulatum. Treatment with oral itraconazole led to complete remission of lesions.


Subject(s)
Aged , Humans , Male , Dermatomycoses/pathology , Histoplasmosis/pathology , Immunocompetence , Penile Diseases/pathology , Antifungal Agents/therapeutic use , Biopsy , Dermatomycoses/drug therapy , Dermatomycoses/immunology , Histoplasma , Histoplasmosis/drug therapy , Histoplasmosis/immunology , Immunocompetence/immunology , Itraconazole/therapeutic use , Penile Diseases/drug therapy , Penile Diseases/immunology , Treatment Outcome
13.
An. bras. dermatol ; 88(6): 937-944, Nov-Dec/2013. tab
Article in English | LILACS | ID: lil-699004

ABSTRACT

Superficial fungal infections of the hair, skin and nails are a major cause of morbidity in the world. Choosing the right treatment is not always simple because of the possibility of drug interactions and side effects. The first part of the article discusses the main treatments for superficial mycoses - keratophytoses, dermatophytosis, candidiasis, with a practical approach to the most commonly-used topical and systemic drugs , referring also to their dosage and duration of use. Promising new, antifungal therapeutic alternatives are also highlighted, as well as available options on the Brazilian and world markets.


As infecções fúngicas superficiais dos cabelos, pele e unhas representam uma causa importante de morbidade no mundo. O tratamento nem sempre é simples, havendo dificuldade na escolha dos esquemas terapêuticos disponíveis na literatura, assim como suas possíveis interações medicamentosas e efeitos colaterais. A segunda parte do trabalho aborda os principais esquemas terapêuticos das micoses superficiais - ceratofitoses, dermatofitoses, candidíase -, possibilitando a consulta prática das drogas tópicas e sistêmicas mais utilizadas, sua dosagem e tempo de utilização. Novas possibilidades terapêuticas antifúngicas também são ressaltadas, assim como as apresentações disponíveis no mercado brasileiro e mundial.


Subject(s)
Humans , Antifungal Agents/therapeutic use , Dermatomycoses/drug therapy , Antifungal Agents/cerebrospinal fluid , Drug Interactions , Time Factors
14.
An. bras. dermatol ; 88(5): 764-774, out. 2013. tab
Article in English | LILACS | ID: lil-689735

ABSTRACT

Superficial fungal infections of the hair, skin and nails are a major cause of morbidity in the world. Choosing the right treatment is not always simple because of the possibility of drug interactions and side effects. The first part of the article discusses the main treatments for superficial mycoses - keratophytoses, dermatophytosis, candidiasis, with a practical approach to the most commonly-used topical and systemic drugs , referring also to their dosage and duration of use. Promising new, antifungal therapeutic alternatives are also highlighted, as well as available options on the Brazilian and world markets.


As infecções fúngicas superficiais dos cabelos, pele e unhas representam uma causa importante de morbidade no mundo. O tratamento nem sempre é simples, havendo dificuldade na escolha dos esquemas terapêuticos disponíveis na literatura, assim como suas possíveis interações medicamentosas e efeitos colaterais. A primeira parte do trabalho aborda os principais esquemas terapêuticos das micoses superficiais - ceratofitoses, dermatofitoses, candidíase - possibilitando a consulta prática das drogas tópicas e sistêmicas mais utilizadas, sua dosagem e tempo de utilização. Novas possibilidades terapêuticas antifungicas também são ressaltadas, assim como as apresentações disponíneis no mercado brasileiro e mundial.


Subject(s)
Humans , Antifungal Agents/therapeutic use , Dermatomycoses/drug therapy , Dermatomycoses/microbiology , Time Factors
16.
Article in English | WPRIM | ID: wpr-21958

ABSTRACT

Penicillium marneffei may cause life-threatening systemic fungal infection in immune-compromised patients and it is endemic in Southeast Asia. A 39-yr-old HIV-infected male, living in Laos, presented with fever, cough, and facial vesiculopapular lesions, which had been apparent for two weeks. CT scans showed bilateral micronodules on both lungs; Pneumocystis jirovecii was identified by bronchoscopic biopsy. Despite trimethoprim-sulfamethoxazole and anti-tuberculosis medications, the lung lesions progressed and the facial lesions revealed central umbilications. Biopsy of the skin lesions confirmed disseminated penicilliosis, with the culture showing P. marneffei hyphae and spores. The P. marneffei was identified by rRNA PCR. A review of the bronchoscopic biopsy indicated penicilliosis. The patient completely recovered after being prescribed amphotericin-B and receiving antiretroviral therapy. This is the first case of penicilliosis in a Korean HIV-infected patient. It is necessary to consider P. marneffei when immunocompromised patients, with a history of visits to endemic areas, reveal respiratory disease.


Subject(s)
Adult , Amphotericin B/therapeutic use , Anti-HIV Agents/therapeutic use , Antifungal Agents/therapeutic use , Bronchoscopy , Dermatomycoses/drug therapy , HIV Infections/diagnosis , Humans , Immunocompromised Host , Laos , Lung Diseases/drug therapy , Male , Penicillium/genetics , Pneumocystis carinii/isolation & purification , Tomography, X-Ray Computed
17.
Rev. chil. infectol ; 28(3): 269-273, jun. 2011. ilus
Article in Spanish | LILACS | ID: lil-597599

ABSTRACT

Mucormycosis or zygomycosis is a rare opportunistic infection caused by aerobic saprophytic fungus that belongs to the class of Zygomycetes Mucorales family. These organisms live in the environment and enter the body by air, gastrointestinal or skin routes, through solutions of continuity of the skin. This microorganism is generally not pathogenic for immunocompetent hosts, being the development of the disease linked with the immune status of the subject. Its mortality is around 50-60 percent; sometimes in spite of early diagnosis and treatment initiation it has a fatal course. Six clinical forms of mucormycosis are described: rhinocerebral, cutaneous, pulmonary, disseminated, gastrointestinal and miscellaneous form. Two cases of patients with primary cutaneous mucormycosis diagnosed in the Pathology Unit of Hernan Henriquez Aravena Hospital of Temuco, Chile are presented here.


La mucormicosis o zigomicosis es una infección oportunista poco frecuente, causada por un hongo sapró-fito aeróbico que pertenece a la clase Zygomycetes de la familia Mucorales. Estos microorganismos viven en el ambiente y penetran en el organismo por vía aérea, gastrointestinal o cutánea a través de soluciones de continuidad de la piel. Este agente generalmente no es patógeno para el hospedero inmunocompetente estando relacionado el desarrollo de la enfermedad con el estado inmune del sujeto. Su mortalidad es cercana a 50-60 por ciento; en ocasiones, a pesar del precoz diagnóstico e instauración del tratamiento, tiene un curso fatal. Se describen seis formas clínicas de mucormicosis: rinocerebral, cutánea, pulmonar, diseminada, gastrointestinal y una forma miscelánea. Se presentan dos casos de pacientes con mu-cormicosis cutánea primaria diagnosticados en la Unidad de Anatomía Patológica del Hospital Hernán Henríquez Aravena de Temuco.


Subject(s)
Adult , Humans , Male , Middle Aged , Dermatomycoses/diagnosis , Mucormycosis/diagnosis , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Dermatomycoses/drug therapy , Dermatomycoses/pathology , Mucormycosis/drug therapy , Mucormycosis/pathology , Severity of Illness Index
18.
Hamdard Medicus. 2011; 54 (2): 21-28
in English | IMEMR | ID: emr-137318

ABSTRACT

Skin diseases have high prevalence throughout the world which accounts for 10% of the workload of the family doctors. One of such disease is dermatophytosis [ringworm] which is caused by dermatophytes. They are more prevalent in economically under developed and developing countries where they contribute as a major health problem. The prevalence of superficial mycotic infections had risen to such a level that skin mycoses now affects more than 20-25% of the world population, making them one of the most frequent form of infections. In spite of the advances in antifungal and corticosteroid therapy which have completely altered the nature of skin clinics, there is no diminution in the number of patients with dermatophytosis attending for assistance. Subsequently the adverse effect of drugs has also worsened the condition. As per the literature of Unani System, two compound drugs viz. [Majoon Ushba] and [Marham Gulabi] which are supposed to be novel combination were chosen for this study as test group. The result was compared with Allopathic drugs viz. Griseofulvin and Sulphur Ointment as standard. Our study includes 30 .cases in each group. After completion of the study it was found that the test group was clinically as well as statistically significant at the same level as that of standard group


Subject(s)
Humans , Male , Female , Arthrodermataceae , Dermatomycoses/drug therapy , Griseofulvin , Phytotherapy , Treatment Outcome
19.
Article in English | WPRIM | ID: wpr-193616

ABSTRACT

Phaeohyphomycosis is a subcutaneous infection caused by dark pigmented fungi, including fungi of the species Phaeoacremonium, Alternaria, Exophiala, and Pyrenochaeta. In August 2005, a 54-yr-old man who had received a renal transplant 5 yr ago was admitted to our hospital with a subcutaneous mass on the third finger of the right hand; the mass had been present for several months. He had been receiving immunosuppressive agents for several years. He underwent excision of the mass, which was followed by aspiration of the wound for bacterial and fungal cultures. Many fungal hyphae were observed on the histology slide treated with periodic acid-Schiff stain. A few white waxy colonies with a woolly texture grew on the Sabouraud dextrose agar at 30degrees C and changed to dark brown in color. Nucleotide sequencing of internal transcribed spacer regions revealed 100% homology to the Phaeoacremonium aleophilum anamorph and Togninia minima teleomorph (514 bp/514 bp). The patient completely recovered after wide surgical excision. Here, we report the first case of phaeohyphomycosis caused by Phaeoacremonium species in a kidney transplant patient in Korea.


Subject(s)
Antifungal Agents/therapeutic use , Ascomycota/genetics , Dermatomycoses/drug therapy , Fingers/surgery , Humans , Immunosuppressive Agents/adverse effects , Kidney Transplantation , Male , Middle Aged , Republic of Korea , Sequence Analysis, DNA , Subcutaneous Tissue/microbiology
20.
Rev. Soc. Bras. Med. Trop ; 43(4): 467-468, jul.-ago. 2010. ilus
Article in English | LILACS | ID: lil-556020

ABSTRACT

Acremonium infection is rare and associated with immunosuppression. A case of recurrent cutaneous Acremonium infection after short term voriconazole use is described. Surgical resection was the definitive therapy. Oral voriconazole was used in the treatment of Acremonium infection, but recurrence was associated with short therapy. Prolonged antifungal therapy and surgical resection are discussed for the treatment of localized lesions.


Infecção por Acremonium é rara e pode estar associada com imunossupressão. Descrevemos um caso de infecção recorrente de pele por Acremonium após tratamento breve com voriconazol. Ressecção cirúrgica foi o tratamento definitivo. Terapia prolongada com antifúngicos e ressecção cirúrgica são discutidas para o tratamento de doenças fúngicas localizadas.


Subject(s)
Humans , Male , Middle Aged , Acremonium/isolation & purification , Dermatomycoses/diagnosis , Kidney Transplantation , Antifungal Agents/therapeutic use , Dermatomycoses/drug therapy , Dermatomycoses/surgery , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Pyrimidines/therapeutic use , Recurrence , Triazoles/therapeutic use
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