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1.
Arch. pediatr. Urug ; 92(2): e307, dic. 2021. ilus, tab
Article in Spanish | LILACS, BNUY, UY-BNMED | ID: biblio-1339135

ABSTRACT

Las porfirias son un grupo complejo y heterogéneo de defectos en la vía de la síntesis del hemo. La porfiria hepato eritropoyética es un subtipo muy poco frecuente y de presentación en la infancia, con compromiso cutáneo predominante. Describimos el caso clínico de una paciente de 5 años, que se presenta con lesiones cutáneas e hipertricosis, se confirma el diagnóstico por elevación de uroporfirinas en orina y secuenciación del gen UROD.


Porphyria is a complex and heterogeneous group of heme synthesis disorder. Hepato-erythropoietic porphyria is a very rare subtype that onsets in childhood, and shows predominant skin involvement. We describe the clinical case of a 5-year-old patient who showed skin lesions and hypertrichosis and whose diagnosis was confirmed due to increased uroporphyrins in urine and UROD gene sequencing


A porfiria é um grupo complexo e heterogêneo de distúrbios da síntese do grupo heme. A porfiria hepato-eritropoiética é um subtipo muito raro que se inicia na infância e mostra envolvimento predominante da pele. Descrevemos o caso clínico de uma paciente de 5 anos que apresentou lesões cutâneas e hipertricose e cujo diagnóstico foi confirmado por aumento de uroporfirinas na urina e sequenciamento do gene UROD.


Subject(s)
Humans , Female , Child, Preschool , Blister/etiology , Porphyria, Hepatoerythropoietic/complications , Porphyria, Hepatoerythropoietic/genetics , Porphyria, Hepatoerythropoietic/urine , Diabetes Mellitus, Type 1/complications , Hypertrichosis/etiology , Uroporphyrinogen Decarboxylase/analysis , Uroporphyrins/urine , Blister/drug therapy , Coproporphyrins/urine , Hypertrichosis/drug therapy
2.
Espaç.saúde ; 22: 1-11, 03/12/2021. ilus
Article in Portuguese | LILACS | ID: biblio-1353792

ABSTRACT

Objetivou-se identificar a síntese do conhecimento científico acerca da contribuição de tecnologias educacionais no cuidado às crianças com Diabetes Mellitus tipo 1. Trata-se de uma revisão integrativa realizada em junho e julho de 2020 nas bases de dados MEDLINE, LILACS e BDENF no período de 2015 a 2019. Após adotar os critérios de inclusão e exclusão ficaram oito artigos. As tecnologias educacionais utilizadas foram plataformas digitais, oficinas educacionais, simulações de casos, pôster e cartilha educacional. Identificou-se limitação de estudos com validação de tecnologias, que abordassem temáticas como atividades físicas, alimentação saudável e enfrentamento de situações psicossociais. Constatou-se a importância da atuação da equipe de enfermagem em intervenções de caráter educativo, realizadas de forma lúdica e criativa, incluindo pais e cuidador durante o processo.


This study aimed to identify the synthesis of scientific knowledge about the contribution of educational technologies in the care of children with type 1 Diabetes Mellitus. This is an integrative review conducted in June and July 2020 in the MEDLINE, LILACS, and BDENF databases of articles from 2015 to 2019. After adopting the inclusion and exclusion criteria, eight articles were selected. The educational technologies used were digital platforms, educational workshops, case simulations, poster, and educational booklet. We identified limitations of studies with validation of technologies that addressed themes such as physical activity, healthy eating, and coping with psychosocial situations. The importance of the nursing team's performance was identified in educational interventions run in a playful and creative way, including parents and caregivers during the process.


Este estudio tuvo como objetivo identificar la síntesis de conocimientos científicos sobre la contribución de las tecnologías educativas en el cuidado de niños con Diabetes Mellitus tipo 1. Se trata de una revisión integradora realizada en junio y julio de 2020 en las bases de datos MEDLINE, LILACS y BDENF en el período 2015-2019. Tras adoptar los criterios de inclusión y exclusión, se adoptaron ocho artículos. Las tecnologías educativas utilizadas fueron plataformas digitales, talleres educativos, simulaciones de casos, póster y folleto educativo. Identificamos limitaciones de estudios con validación de tecnologías que abordaban temas como la actividad física, la alimentación saludable y el afrontamiento de situaciones psicosociales. Se verificó la importancia del desempeño del equipo de enfermería en las intervenciones educativas realizadas de una manera lúdica y creativa, incluyendo los padres y cuidadores durante el proceso.


Subject(s)
Humans , Educational Technology , Diabetes Mellitus, Type 1
3.
Medicina (B.Aires) ; 81(5): 843-845, oct. 2021. graf
Article in English | LILACS | ID: biblio-1351058

ABSTRACT

Abstract We present a case of subcutaneous insulin resistance syndrome, a rare entity, consisting of subcutaneous and intramuscular insulin resistance, with normal or almost normal sensitivity to insulin when administered intravenously. Its cause is unknown and its treatment is challenging. Our patient required a pancreas transplant.


Resumen Presentamos un caso de síndrome de resistencia subcutánea a la insulina, entidad in frecuente, que consiste en resistencia a la insulina por vía subcutánea e intramuscular, con sensibilidad normal o casi normal a la insulina cuando se aplica por vía intravenosa. Se desconoce su causa y su tratamiento es un desafío. Nuestra paciente requirió trasplante de páncreas.


Subject(s)
Humans , Insulin Resistance , Pancreas Transplantation , Metabolic Syndrome , Diabetes Mellitus, Type 1 , Insulin
4.
Rev. cuba. pediatr ; 93(3): e1505, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1347539

ABSTRACT

Introducción: La diabetes mellitus tipo 1 es una enfermedad autoinmunitaria que se relaciona con alteraciones tiroideas. Objetivo: Describir la relación que existe entre diabetes mellitus tipo 1 y enfermedad tiroidea autoinmune. Métodos: Se realizó una revisión de la literatura nacional e internacional de los últimos 15 años en bases de datos, en español y en inglés. Se utilizaron las siguientes palabras clave: "diabetes mellitus tipo 1", "autoinmunidad", enfermad tiroidea autoinmune", "disfunción tiroidea" y "anticuerpos antitiroideos. Análisis e integración de la información: La alteración más frecuente es el hipotiroidismo subclínico y se presenta con mayor frecuencia en el sexo femenino, por lo que se sugiere realizar periódicamente el perfil tiroideo a estos pacientes. Conclusiones: Se debe tener en cuenta en la práctica clínica estas implicaciones para brindar un tratamiento oportuno, mejorar complicaciones derivadas como las enfermedades cardiovasculares y disminuir las cifras de morbilidad y mortalidad(AU)


Introduction: Type 1 diabetes mellitus is an autoimmune disease that is related to thyroid abnormalities. Objective: Describe the relationship between type 1 diabetes mellitus and autoimmune thyroid disease. Methods: A review of the national and international literature of the last 15 years was carried out in databases, in Spanish and in English. The following keywords were used: "type 1 diabetes mellitus", "autoimmune", "autoimmune thyroid disease", "thyroid dysfunction" and "antithyroid antibodies. Analysis and integration of information: The most common alteration is subclinical hypothyroidism and it occurs most often in the female sex, so it is suggested to periodically perform the thyroid profile to these patients. Conclusions: These implications should be taken into account in clinical practice to provide timely treatment, improve complications such as cardiovascular disease and reduce morbidity and mortality figures(AU)


Subject(s)
Humans , Thyroid Diseases/therapy , Thyroiditis, Autoimmune , Diabetes Mellitus, Type 1/etiology , Review Literature as Topic
5.
Online braz. j. nurs. (Online) ; 20(supl.1): e20216517, 09 setembro 2021. tab
Article in English, Spanish, Portuguese | LILACS, BDENF | ID: biblio-1291314

ABSTRACT

OBJETIVO: analisar os fatores relacionados às práticas de prevenção da covid-19 em usuários que vivem com diabetes mellitus. MÉTODO: estudo de corte transversal, analítico e exploratório, desenvolvido com 300 indivíduos acompanhados na Estratégia Saúde da Família e tinham diagnóstico médico de diabetes mellitus tipo 1 ou tipo 2. Na análise bivariada, as comparações entre variáveis quantitativas e categóricas se deram por meio dos testes U de Mann-Whitney, Kruskal-Wallis, e o teste de comparações múltiplas de Dunn. RESULTADOS: verificou-se relação entre o escore total do nível de práticas de prevenção da covid-19 e as variáveis sexo (p<0,001), faixa etária (p=0,003), grau de escolaridade (p=0,018) e comorbidades (p=0,014). CONCLUSÃO: Conclui-se que as pessoas do sexo feminino, com faixas etárias e graus de escolaridade mais elevadas, e com comorbidade apresentaram escore total do nível de práticas de prevenção da covid-19 mais elevado.


OBJECTIVE: to analyze the factors related to covid-19 prevention practices in users living with diabetes mellitus. METHOD: a cross-sectional, analytical and exploratory study, developed with 300 individuals part of the Family Health Strategy and who had a medical diagnosis of type 1 or type 2 diabetes mellitus. In the bivariate analysis, comparisons between quantitative and categorical variables were performed through mann-whitney u tests, Kruskal-Wallis, and dunn's multiple comparison test. RESULTS: there was a relationship between the total score of the level of prevention practices of the covid-19 and the variables sex (p<0.001), age group (p=0.003), formal educational level (p=0.018) and comorbidities (p=0.014). CONCLUSION: It was concluded that females, in older age groups and higher levels of education, and with a comorbidity presented a total score of the highest level of covid-19 prevention practices.


OBJETIVO: analizar los factores relacionados con las prácticas de prevención del covid-19 em usuarios que viven con diabetes mellius. MÉTODO: Método: estudio transversal, analítico y exploratorio, desarrollado con 300 individuos seguidos en la Estrategia Salud de la Familia y con diagnóstico médico de diabetes mellitus tipo 1 o tipo 2. En el análisis bivariado se realizaron comparaciones entre variables cuantitativas y categóricas mediante Pruebas U de Mann-Whitney, Kruskal-Wallis y prueba de comparación múltiple de Dunn. RESULTADOS: hubo relación entre la puntuación total del nivel de prácticas de prevención del covid-19 y las variables sexo (p <0,001), grupo de edad (p = 0,003), nivel educativo (p = 0,018) y comorbilidades (p = 0,014). CONCLUSIÓN: Se concluyó que las personas del sexo femenino, con mayores grupos de edad y niveles de educación, y con comorbilidad tenían una puntuación total más alta para el nivel de prácticas de prevención de covid-19.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Diabetes Mellitus, Type 1 , Diabetes Mellitus, Type 2 , COVID-19/prevention & control , Cross-Sectional Studies , Family Health Strategy , Disease Prevention
6.
Rev. cuba. pediatr ; 93(2): e1303, tab, fig
Article in Spanish | LILACS, CUMED | ID: biblio-1280367

ABSTRACT

Introducción: La diabetes mellitus tipo 1 es una enfermedad metabólica órgano específica caracterizada por la destrucción y pérdida progresiva de las células β de los islotes pancreáticos. Objetivo: Evaluar la alimentación, nutrición y actividad física según el control metabólico en pacientes con diabetes mellitus tipo 1. Métodos: Estudio de evaluación con diseño transversal en 81 pacientes atendidos en el Hospital Pediátrico Universitario "William Soler", de 2016 a 2019. Los pacientes se distribuyeron en dos grupos según los valores de la hemoglobina glicosilada (control metabólico: n=39 y sin control metabólico: n=42). Se midieron variables de: alimentación, nutrición y actividad física por medio de análisis inferencial (análisis de varianza, Ji-cuadrada de independencia corregida. Resultados: La media de hemoglobina glicosilada en diabéticos controlados fue 6,1 por ciento y en no controlados 11,0 por ciento, significativamente diferentes (p= 0,000). El sexo femenino y los adolescentes superaron 50 por ciento tanto en controlados como en no controlados. La lactancia materna fue inadecuada (> 60 por ciento), los diabéticos eutróficos fueron más de 70 por ciento, el comienzo de la alimentación fue precoz (> 45 por ciento), el control metabólico, dependiente de la calidad de la dieta y la actividad física En el control metabólico inadecuado: 47, 6 por ciento ( 5 años practicaban ejercicios menos de 3 veces por semana y 52,4 por ciento consumían dieta hipercalórica. Conclusión: La actividad física y la calidad de la dieta influyen en el control metabólico de los pacientes diabéticos estudiados(AU)


Introduction: Type 1 diabetes mellitus is a specific organ metabolic disease characterized by the progressive destruction and loss of pancreatic β cells. Objective: Asses the diet, nutrition and physical activity according to metabolic control in patients with type 1 diabetes mellitus. Methods: Assessment study with cross-sectional design in 81 patients attended at "William Soler" University Pediatric Hospital, from 2016 to 2019. Patients were distributed in two groups according to the values of glycosylated hemoglobin (metabolic control: n=39, and without metabolic control: n=42). The following variables were measured: food, nutrition and physical activity through inferential analysis (variance analysis, Ji-square´s corrected independence, contingency coefficient and odds ratio). Results: The mean of glycosylated hemoglobin in controlled diabetics was 6.1 percent and in non-controlled ones it was 11.0 percent; significantly different (p= 0.000). The female sex and the adolescents exceeded the 50 percent in both controlled and non-controlled groups, respectively. Breastfeeding was inadequate (> 60 percent), eutrophic diabetics were more than 70 percent, the start of feeding was early (> 45 percent), metabolic control was dependent on diet quality and physical activity. In the inadequate metabolic control: 47.6 percent ( 5 years exercised less than 3 times per week and 52.4 percent consumed a high calorie diet. Conclusion: Physical activity and diet quality influence metabolic control of diabetes in the studied population(AU)


Subject(s)
Humans , Male , Female , Adolescent , Diabetes Mellitus, Type 1 , Nutritional Sciences , Hospitals, Pediatric
8.
Ciênc. Saúde Colet ; 26(5): 1691-1700, maio 2021. graf
Article in English, Portuguese | LILACS | ID: biblio-1249512

ABSTRACT

Resumo No cenário do Diabetes Mellitus tipo 1 (DM1), uma prática incentivada é o autocuidado. Dessa forma, objetivou-se elaborar e validar um aplicativo móvel (APP) para a promoção do autocuidado em adolescentes com DM1. O método foi divido em duas etapas: elaboração e validação, que vão desde a revisão de literatura, benchmarking, construção do protótipo e validação por especialistas. A construção do APP foi subsidiada pelos sete passos propostos pela American Association of Diabetes Educators. Foram desenhadas as telas e selecionaram-se as possíveis funções; após o desenho, o protótipo do APP foi desenvolvido e nomeado como "DM Agendinha". O processo de validação de conteúdo foi mediado pelo instrumento Suitability Assessment of Materials, por meio do qual o percentual obtido foi de 85,3%, caracterizando o APP como "Material Superior". Para a validação técnica, empregou-se o questionário Smartphone Usability questionnaire, que obteve um Índice de Validade de Conteúdo global de 0,96. Conclui-se, portanto, que o uso desse material por parte dos adolescentes favorecerá a aquisição de novos conhecimentos e a adesão de práticas saudáveis, tendo em vista que se trata de uma tecnologia de caráter eletrônico e de fácil compreensão.


Abstract Self-care is encouraged in the type 1 Diabetes Mellitus (DM1) setting. Thus, this research aimed to develop and validate a mobile application (APP) to promote self-care for adolescents with DM1. The method was divided into two stages: development and validation, ranging from literature review, benchmarking, prototype construction to validation by specialists. The APP construction was subsidized by the seven steps proposed by the American Association of Diabetes Educators. The screens were designed and possible functions were selected. After the design, the APP prototype was developed and named "DM Agendinha". The content validation process was mediated by the Suitability Assessment of Materials tool, where the percentage obtained was 85.3%, characterizing the APP as "Superior Material". The Smartphone Usability questionnaire was employed for technical validation, and the APP reached a global Content Validity Index of 0.96. We concluded, therefore, that the use of this material by adolescents will favor the acquisition of new knowledge and adherence to healthy practices, considering that it is a highly intelligible electronic technology.


Subject(s)
Humans , Adolescent , Telemedicine , Diabetes Mellitus, Type 1/therapy , Mobile Applications , Self Care , Technology
9.
Cienc. Salud (St. Domingo) ; 5(2): [87-94], Ene-Abr. 2021. ilus, tab
Article in Spanish | LILACS | ID: biblio-1363042

ABSTRACT

Introducción: la diabetes tipo 1 es una enfermedad crónica de alto impacto económico con gran capacidad de ser controlada, la misma no tiene ninguna descripción local previa. Su principal causa de mortalidad es los eventos cardiovasculares y el manejo adecuado la disminuye considerablemente. Objetivo: determinar el riesgo cardiovascular en pacientes adultos con diabetes tipo 1 en la ciudad de Santiago de los Caballeros, República Dominicana. Método: se realizó un estudio descriptivo transversal multicéntrico con 39 pacientes en el período de junio a noviembre de 2019. La calculadora "Steno T1 Risk Engine" se utilizó para estimar el riesgo cardiovascular. Resultados: se obtuvo una relación significativa entre la albuminuria (p = 0.0127), presión arterial sistólica (p = 0.0002), tiempo de diagnóstico (p = 0.0037) y nivel de riesgo cardiovascular. La hemoglobina glucosilada (p = 0,7884) y la actividad física (p = 0.706) no mostraron una relación significativa con el riesgo cardiovascular. Conclusión: el nivel de riesgo cardiovascular promedio es bajo, con probabilidades <10 % de un evento cardiovascular agudo dentro de los 10 años. Esta herramienta permite incluir una evaluación cardiovascular rutinaria con datos que perfilen el tratamiento orientado a disminuir complicaciones vasculares, mortalidad y aumentar adherencia al tratamiento.


Introduction: Type 1 diabetes is a chronic condition with a high economic impact but potentially controllable. There is no previous local description of this condition. Its main fatality cause is due to cardiovascular events and its proper management can diminish it. Objective: This study aimed to determine the cardiovascular risk in adult patients with type 1 diabetes mellitus in the city of Santiago de los Caballeros, Dominican Republic. Method: A descriptive multicenter cross-sectional study was done on 39 patients in the period of June-November 2019. "Steno T1 Risk Engine" calculator estimated the cardiovascular risk. Results: A significant relationship was obtained between albuminuria (p = 0.0127), systolic blood pressure (p = 0.0002), diagnosis time (p = 0.0037) and cardiovascular risk level. Glycated hemoglobin (p = 0.7884) and physical activity (p = 0.7063) did not show a significant relationship with cardiovascular risk. Conclusion: Average cardiovascular risk level is low with <10% probabilities of an acute cardiovascular event within 10 years. This tool could lead to quick cardiovascular risk evaluations to guide the treatment lowering vascular complications, mortality and increasing treatment adherence.


Subject(s)
Primary Health Care , Cardiovascular Diseases , Diabetes Mellitus, Type 1 , Patients , Dominican Republic
11.
Acta Physiologica Sinica ; (6): 10-16, 2021.
Article in Chinese | WPRIM | ID: wpr-878230

ABSTRACT

The aim of the present study was to observe the activation of microglia in the prefrontal cortex of type 1 diabetes mellitus (T1DM) mice, and the expression of the marker genes of the disease-associated microglia (DAM) associated with neurodegenerative diseases. Sixty healthy adult male C57BL/6J mice were randomly divided into two groups, normal control (CON) group and T1DM group. Streptozocin (STZ) was injected intraperitoneally to induce T1DM mice. The spatial learning and memory function of mice was detected by Morris water maze at the 8th week after the successful model establishment. The number and activation of microglia in the prefrontal cortex of mice were detected by immunofluorescence staining and Western blot. Changes in the mRNA level of several DAM molecular markers were detected by RT-FQ-PCR. The results showed that, compared with CON mice, the fasting blood glucose of T1DM mice increased significantly, while the body weight of T1DM mice decreased remarkably (P < 0.05). The escape latency of water maze in T1DM mice was longer than that in CON mice (P < 0.05). Compared with CON group, the Iba1 protein expression and the number of microglia in prefrontal cortex of T1DM group increased significantly (P < 0.05). In addition, the mRNA levels of several DAM markers in prefrontal cortex of T1DM group were increased significantly (P < 0.05). These results suggest that the microglia are activated and transformed to DAM type in the prefrontal cortex of T1DM mice.


Subject(s)
Animals , Diabetes Mellitus, Experimental , Diabetes Mellitus, Type 1 , Hippocampus , Male , Mice , Mice, Inbred C57BL , Microglia , Prefrontal Cortex
12.
Chinese Medical Journal ; (24): 1031-1042, 2021.
Article in English | WPRIM | ID: wpr-878118

ABSTRACT

Type 1 diabetes (T1D) is an autoimmune disease that resulted from the severe destruction of the insulin-producing β cells in the pancreases of individuals with a genetic predisposition. Genome-wide studies have identified HLA and other risk genes associated with T1D susceptibility in humans. However, evidence obtained from the incomplete concordance of diabetes incidence among monozygotic twins suggests that environmental factors also play critical roles in T1D pathogenesis. Epigenetics is a rapidly growing field that serves as a bridge to link T1D risk genes and environmental exposures, thereby modulating the expression of critical genes relevant to T1D development beyond the changes of DNA sequences. Indeed, there is compelling evidence that epigenetic changes induced by environmental insults are implicated in T1D pathogenesis. Herein, we sought to summarize the recent progress in terms of epigenetic mechanisms in T1D initiation and progression, and discuss their potential as biomarkers and therapeutic targets in the T1D setting.


Subject(s)
Diabetes Mellitus, Type 1/genetics , Epigenesis, Genetic/genetics , Genetic Predisposition to Disease/genetics , Humans , Incidence , Twins, Monozygotic
13.
Article in Chinese | WPRIM | ID: wpr-879819

ABSTRACT

OBJECTIVE@#To study the clinical effect of continuous subcutaneous insulin infusion (CSⅡ) versus multiple daily injection (MDI) on blood glucose control in children with type 1 diabetes mellitus (T1DM).@*METHODS@#A retrospective analysis was performed on the medical data of 91 children with T1DM who were treated with CSⅡ for more than 1 year and 75 children with T1DM who were treated with MDI. The two groups were compared in terms of glycosylated hemoglobin (HbA1C) and the recurrence of diabetic ketoacidosis (DKA) to evaluate the difference in the efficacy during the 3-year follow-up. A survey was conducted for the children in the CSⅡ group and their family members to investigate the degree of satisfaction with insulin pump.@*RESULTS@#There was no significant difference in age, sex, and course of diabetes between the CSⅡ and MDI groups at disease onset and in the first year, the second year, and the third year of follow-up (@*CONCLUSIONS@#Children with T1DM treated with CSⅡ have a better control of blood glucose than those treated with MDI, and children and their family members are satisfied with CSⅡ treatment. Therefore, it holds promise for clinical application.


Subject(s)
Child , Diabetes Mellitus, Type 1/drug therapy , Diabetic Ketoacidosis , Follow-Up Studies , Humans , Insulins , Retrospective Studies
14.
Article in Chinese | WPRIM | ID: wpr-879565

ABSTRACT

OBJECTIVE@#To report on the clinical features and result of genetic testing for a child featuring immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.@*METHODS@#Clinical records, genetic testing, laboratory investigation and treatment of the child were summarized in addition with a comprehensive review of the literature.@*RESULTS@#The 3-year-old boy was administered due to intractable diarrhea, recurrent infections, liver dysfunction and failure to thrive, though no diabetes or skin disorder was observed. Laboratory testing showed elevated liver enzymes and total IgE, decreased albumin and electrolyte imbalance. Gastrointestinal endoscopy revealed erosion and granules in the duodenum, and edema in the terminal ileum and colon. Biopsies showed villous atrophy in the duodenum and terminal ileum. Genetic testing revealed that the patient has carried a missense c.1087A>G (p.I363V) variant in the exon 10 of the FOXP3 gene. He was treated with enteral and parenteral nutrition, anti infection and Sirolimus, and was waiting for hemopoietic stem cell transplantation.@*CONCLUSION@#Although IPEX syndrome usually occur during infancy, it should not be ruled out solely based on the age, and its presentation can be variable. For male children with refractory diarrhea, autoimmune disorder and growth retardation, the diagnosis should be suspected and confirmed by genetic testing.


Subject(s)
Child, Preschool , Diabetes Mellitus, Type 1/genetics , Diarrhea/genetics , Forkhead Transcription Factors/genetics , Genetic Diseases, X-Linked/genetics , Genetic Testing , Humans , Immune System Diseases/genetics , Male , Mutation , Polyendocrinopathies, Autoimmune/genetics
16.
Arq. odontol ; 57: 175-188, jan.-dez. 2021. ilus, tab
Article in Portuguese | LILACS, BBO | ID: biblio-1344667

ABSTRACT

Objetivo: O objetivo dessa revisão sistemática e meta-análise foi avaliar estudos que fizeram uma comparação da ocorrência de cárie dentária entre crianças/adolescentes com Diabetes tipo 1 (DM1) e crianças/adolescentes sem essa condição. Métodos:Buscas computadorizadas no Web ofScience, Scopus, Lilacs, PubMed, OpenGrey e Google Scholar foram realizadas até dezembro de 2020. A seleção dos estudos foi feita por dois autores independentemente. Referências que preenchiam os critérios de elegibilidade foram incluídas. O risco de viés foi avaliado com a escala Newcastle Ottawa. Meta-análises foram conduzidas. Diferença média (DM) e intervalos de confiança (IC) foram fornecidos. Resultados: Durante as buscas nas bases de dados, 751 referências foram recuperadas. Após remoção de 102 duplicatas, 649 referências foram avaliadas e 16 estudos foram incluídos nessa revisão sistemática e meta-análise. Os estudos incluídos tiveram resultados discrepantes. Duas meta-análises demonstraram que não houve diferença significativa na média de dentes permanentes com cárie entre crianças/adolescentes com DM1 e crianças/adolescentes sem DM1 (DM = 0,07; IC = -0,68 ­ 0,82) e que não houve diferença significativa na média de superfícies de dentes permanentes com cárie entre crianças/adolescentes com DM1 e crianças/adolescentes sem DM1 (DM = 0,20; IC = -2,22 ­ 2,61). Uma terceira meta-análise revelou que crianças/adolescentes sem DM1 apresentavam uma média de dentes decíduos com cárie significativamente maior do que crianças/adolescentes com DM1 (DM = 0,34; IC = 0,31 ­ 0,37). O maior problema de risco de viés dos estudos foi para a definição dos controles e comparação de casos e controles. Conclusão: A ocorrência de cárie parece ser menor entre crianças/adolescentes com DM1 em comparação a crianças/adolescentes sem DM1.


Aim:The aim of this systematic review and meta-analysis was to evaluate studies in which children/adolescents with type 1 Diabetes (DM1) were compared with children/adolescents without DM1 as regards dental caries. Methods: Electronic searches in Web ofScience, Scopus, Lilacs, PubMed, OpenGrey, and Google Scholar databases were conducted up to December/2020. Study selection was carried out separately by two reviewers. References that met the eligibility criteria were included. Risk of bias was evaluated using the Newcastle Ottawa scale. Meta-analyses were conducted. Mean difference (MD) and confidence intervals (CI) were provided. Results:In the database searches, 751 references were retrieved. Following the removal of 102 duplicates, 649 references were assessed, and 16 studies were included in this systematic review and meta-analysis. Discrepancies in results were found among the included studies. Two meta-analyses demonstrated no significant difference between children/adolescents with DM1 and children/adolescents without DM1 regarding the mean number of permanent teeth with caries (MD = 0.07; CI = -0.68 ­ 0.82), as well as no significant difference between children/adolescents with DM1 and children/adolescents without DM1 with respect to the mean number of permanent tooth surfaces with caries (MD = 0.20; CI = -2.22 ­ 2.61). The third meta-analysis revealed that children/adolescents without DM1 had a significantly higher mean number of primary teeth with caries in comparison to children/adolescents with DM1 (MD = 0.34; CI = 0.31 ­ 0.37). The major issues in the risk of bias assessment were the definition of controls and comparison between cases and controls. Conclusion: The occurrence of caries seems to be lower in children/adolescents with DM1 than in children/adolescents without DM1.


Subject(s)
Child , Adolescent , Adolescent , Meta-Analysis , Dental Care for Children , Dental Caries , Diabetes Mellitus, Type 1 , Systematic Review
17.
Esc. Anna Nery Rev. Enferm ; 25(4): e20200270, 2021.
Article in Portuguese | LILACS, BDENF | ID: biblio-1154202

ABSTRACT

Resumo Objetivo compreender a relação que as mulheres com diabulimia têm com o corpo. Método pesquisa qualitativa, desenvolvida com o Método da História Oral Temática, com quatro mulheres entre 18 e 30 anos que autorreferiram diabulimia. Resultados a relação das mulheres com o seu corpo foi pautada pela pressão social de magreza feminina que distorce a autoimagem, gera insatisfação com o corpo e a diminuição da autoestima. A perda de peso é proporcionalmente associada ao aumento da aceitação social e justifica a utilização de métodos deletérios à saúde como a diminuição da dose ou a suspensão do uso de insulina. As narradoras demonstraram conhecer os riscos, mas admitiram repeti-la em determinados contextos. Considerações finais e implicações para a prática o desejo que as mulheres com Diabetes Mellitus têm de perder peso precisa ser incorporado às estratégias de cuidado com a atenção dos profissionais da saúde à subjetividade, atuando para reconhecer e prevenir os transtornos alimentares em mulheres com diabetes e minimizar a adoção de ações prejudiciais à saúde.


Resumen Objetivo comprender la relación que tienen las mujeres con diabulimia con el cuerpo. Método investigación cualitativa, desarrollada con el Método de Historia Oral Temática, con cuatro mujeres entre 18 y 30 años que autoinformado diabulimia. Resultados la relación de la mujer con su cuerpo estuvo guiada por la presión social de la delgadez femenina que distorsiona la imagen de sí misma, genera insatisfacción con el cuerpo y la disminución de la autoestima. La pérdida de peso se asocia proporcionalmente con una mayor aceptación social y justifica el uso de métodos nocivos para la salud, como reducir la dosis o suspender el uso de insulina. Los narradores demostraron conocer los riesgos, pero admitieron repetirlo en determinados contextos. Consideraciones finales e implicaciones para la práctica el deseo que tienen las mujeres con Diabetes Mellitus de adelgazar debe incorporarse a las estrategias de atención con la atención de los profesionales de la salud a la subjetividad, actuando para reconocer y prevenir los trastornos alimentarios en mujeres con diabetes y minimizar la adopción de acciones nocivas para la salud.


Abstract Objective to understand the relationship that women with diabulimia have with the body. Method a qualitative research, developed with the Thematic Oral History Method, with four women between 18 and 30 years of age who reported diabulimia. Results women's relationship with their bodies has been guided by the social pressure of female thinness that distorts self-image, generates dissatisfaction with the body and diminishes self-esteem. Weight loss is proportionally associated with increased social acceptance and justifies the use of harmful methods to health such as reducing the dose or suspending the use of insulin. The narrators showed to know the risks, but admitted to repeat it in certain contexts. Final considerations and implications for practice the desire that women with Diabetes Mellitus have to lose weight needs to be incorporated into the strategies of care with the attention of health professionals to subjectivity, acting to recognize and prevent eating disorders in women with diabetes and minimize the adoption of actions harmful to health.


Subject(s)
Humans , Female , Adult , Young Adult , Body Image , Diabetes Mellitus, Type 1/therapy , Diabulimia/psychology , Qualitative Research , Insulin/therapeutic use
18.
Rev. Esc. Enferm. USP ; 55: e03725, 2021.
Article in English | LILACS, BDENF | ID: biblio-1279639

ABSTRACT

ABSTRACT Objective: To identify the main challenges faced by children with type 1 diabetes mellitus and describe their coping strategies. Method: Qualitative study conducted with a semi-structured interview with children aged 8 to 11 with type 1 diabetes mellitus diagnosis who received care in the outpatient clinic of a university hospital in the state of Rio de Janeiro, Brazil. The results have been analyzed and categorized as per thematic analysis. Results: Five children have participated. The reports have emerged from the systematization of the qualitative data, in a process of apprehending meaning from statements of children and adolescents, which led to the category "Living with diabetes", including two subcategories: "Challenges to disease coping" and "Family participation and support in the disease process". Conclusion: The process of disease coping is observed to occur differently for each child. However, family participation and support, as well as communication with health professionals, are fundamental in this process.


RESUMEN Objetivo: Identificar los principales desafíos para los niños con diabetes mellitus tipo 1 y describir las estrategias de afrontamiento que utilizan para adaptarse. Método: Estudio cualitativo, realizado a través de entrevistas semiestructuradas con niños de 8 a 11 años diagnosticados con diabetes mellitus tipo 1 y atendidos en el ambulatorio de un hospital universitario del estado de Rio de Janeiro, en Brasil. Los resultados se analizaron y clasificaron según el análisis temático. Resultados: Participaron cinco niños. Los relatos surgieron de la sistematización de los datos cualitativos, en un proceso de aprehensión del significado de los testimonios de niños y adolescentes, que derivó en la categoría "Vivir con diabetes", con dos subcategorías: "Desafíos en el afrontamiento de la enfermedad" y "Participación y apoyo de la familia en el proceso de la enfermedad". Conclusión: Se constata que el proceso de afrontamiento de la enfermedad ocurre singularmente con cada niño. Sin embargo, la participación y el apoyo de la familia, así como la comunicación de los profesionales sanitarios, son esenciales en este proceso.


RESUMO Objetivo: Identificar os principais desafios vivenciados pela criança com diabetes mellitus tipo 1 e descrever as estratégias de enfrentamento que utilizam para se adaptarem. Método: Estudo de abordagem qualitativa, realizado por meio de entrevista semiestruturada com crianças de 8 a 11 anos com diagnóstico de diabetes mellitus tipo 1 atendidas em ambulatório de um hospital universitário no Estado do Rio de Janeiro. Os resultados foram analisados e categorizados segundo análise temática. Resultados: Participaram cinco crianças. Os relatos emergiram da sistematização dos dados qualitativos, em um processo de apreensão de significado dos depoimentos das crianças e adolescentes, que derivou na categoria "Viver com diabetes", com duas subcategorias: "Desafios no enfrentamento do adoecimento" e "Participação e apoio da família no processo do adoecimento". Conclusão: Constata-se que o processo de enfrentamento do adoecimento ocorre de forma singular para cada criança. No entanto, a participação e o apoio da família, assim como a comunicação dos profissionais de saúde, são fundamentais nesse processo.


Subject(s)
Child , Diabetes Mellitus, Type 1 , Pediatric Nursing , Adaptation, Psychological , Family , Chronic Disease
19.
Esc. Anna Nery Rev. Enferm ; 25(1): e20190343, 2021. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1124793

ABSTRACT

RESUMO Objetivo descrever o processo de construção, avaliação e adequação de vídeos educativos sobre aplicação de insulina direcionados a pacientes adultos e cuidadores. Método estudo metodológico, de caráter descritivo, realizado em três fases: construção, avaliação e adequação. A construção dos vídeos foi realizada com base em revisão de literatura e no protocolo do município. A avaliação foi realizada com experts, por meio de um instrumento construído pelos pesquisadores. O nível de concordância entre os experts foi avaliado pelo índice de validade do conteúdo, que orientou o processo de adequação do material. Resultados os vídeos foram construídos contemplando os principais pontos críticos relacionados à aplicação de insulina. Os itens que obtiveram índice de validade de conteúdo < 0,8 foram reformulados. Conclusão e Implicações para a prática foram produzidos dois vídeos que abordam o transporte, armazenamento, preparo e aplicação da insulina, descarte de perfurocortantes e monitorização da glicemia. Os vídeos educativos construídos podem ser considerados ferramentas facilitadoras do processo de educação em diabetes mellitus e úteis na uniformização de orientações. A descrição do processo de construção, avaliação e adequação pode encorajar outros profissionais a desenvolver materiais que respondam às necessidades de seus contextos de trabalho e assim melhorar e qualificar o cuidado às pessoas.


RESUMEN Objetivo describir el proceso de construcción, evaluación y adecuación de vídeos educativos sobre la aplicación de insulina dirigidos a pacientes adultos y cuidadores. Método estudio de carácter descriptivo realizado en tres fases: construcción, evaluación y adecuación. La construcción de los vídeos se realizó en base a una revisión de la literatura y en el protocolo del municipio. La evaluación se realizó con expertos, utilizando un instrumento construido por los investigadores, el nivel de acuerdo entre los expertos se evaluó mediante el índice de validez de contenido, que guió el proceso de adaptación del material. Resultados los vídeos fueron construidos cubriendo los principales puntos críticos relacionados con la aplicación de insulina. Los ítems que obtuvieron un índice de validez de contenido <0.8 fueron reformulados. Conclusión e Implicaciones para la práctica se realizaron dos vídeos que abordan el transporte, el almacenamiento, la preparación y la aplicación de insulina, la eliminación de objetos punzantes y el control de la glucosa en sangre. Los vídeos educativos construidos pueden considerarse herramientas que facilitan el proceso de educación en diabetes mellitus y útiles para estandarizar las pautas. La descripción del proceso de construcción, evaluación y adaptación puede alentar a otros profesionales a desarrollar materiales que respondan a las necesidades de sus contextos de trabajo y así mejorar la atención a las personas.


ABSTRACT Objective to describe the process of development, evaluation, and adaptation of educational videos on insulin application whose target audience was adult patients and caregivers. Methods descriptive and methodological study, carried out in three phases: development, evaluation, and adaptation. The development of the videos was based on a literature review and the municipality's protocol. The evaluation was carried out by experts by applying an instrument designed by the researchers, and the level of agreement between the experts was assessed by the content validity index, which guided the material adaptation process. Results the videos were developed to address the main critical points related to insulin application. The items that obtained a content validity index < 0.8 were reformulated. Conclusion and implications for practice two videos were made addressing insulin transport, storage, preparation and application, sharps disposal, and blood glucose monitoring. The educational videos made in the present study can be considered tools that contribute to education in diabetes mellitus and are useful for standardizing guidelines. The description of the development, evaluation, and adaptation process can encourage other professionals to develop materials that meet the needs found in their work contexts and, consequently, improve and qualify the care provided to their patients.


Subject(s)
Humans , Audiovisual Aids , Patient Education as Topic , Diabetes Mellitus, Type 1/drug therapy , Insulin/administration & dosage , Self Care , Insulin/therapeutic use
20.
Esc. Anna Nery Rev. Enferm ; 25(5): e20200282, 2021. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1286370

ABSTRACT

Resumo Objetivos descrever o processo de elaboração e avaliação de tecnologia educativa destinada à promoção do cuidado de crianças com diabetes. Método pesquisa metodológica desenvolvida em duas fases: elaboração e avaliação. A fase de elaboração compõe: revisão de literatura; diagnóstico situacional e elaboração das ilustrações; layout; design e textos. Aplicou-se a escala Likert para a avaliação de conteúdo. Os dados foram analisados por meio do coeficiente alfa de Cronbach, Índice de Validade de Conteúdo e nível de concordância. Resultados a definição da temática teve como base as demandas percebidas no diagnóstico situacional e a revisão de literatura. A seleção das imagens foi realizada por meio de fotografias, banco de imagens e Illustrator. As informações foram construídas como história em quadrinhos com o auxílio de designer gráfico. A tecnologia, avaliada por 12 profissionais de saúde, demonstrou nível de confiabilidade satisfatório conforme o coeficiente alfa de Cronbach (0,7121). O Índice de Validade de Conteúdo (0,875) e o nível de concordância (91,67) foram classificados como altos. Conclusão este estudo apresentou considerações relevantes na promoção do cuidado e no aumento do escopo de possibilidades de intervenções do profissional de saúde na perspectiva do cuidado centrado na criança e na família.


Resumen Objetivos describir el proceso de elaboración y evaluación de tecnología educativa orientada a promover la atención de niños con diabetes. Método investigación metodológica desarrollada en dos fases: elaboración y evaluación. La fase de elaboración comprende: revisión de la literatura; diagnóstico situacional y elaboración de las ilustraciones; layout; design y textos. Se aplicó la Escala Likert para evaluar el contenido. Los datos se analizaron mediante el coeficiente alfa de Cronbach, el índice de validez de contenido y el nivel de acuerdo. Resultados la definición del tema se basó en las demandas percibidas en el diagnóstico situacional y revisión de la literatura. La selección de imágenes se realizó a través de fotografías, banco de imágenes e Illustrator. Las informaciones se construyeron como un cómic con la ayuda de un diseñador gráfico. La tecnología, evaluada por 12 profesionales de la salud, mostró un nivel satisfactorio de confiabilidad, según el coeficiente alfa de Cronbach (0,7121). El índice de validez de contenido (0,875) y el nivel de acuerdo (91,67) se clasificaron como altos. Conclusión este estudio presentó consideraciones relevantes en la promoción del cuidado y un aumento en el alcance de las posibilidades de intervención por parte del profesional de la salud, desde la perspectiva del cuidado centrado en el niño y en la familia.


Abstract Objectives to describe the process of development and evaluation of an educational technology aimed at promoting the care of children with diabetes. Method a methodological research developed in two phases: elaboration and evaluation. The elaboration phase comprises: literature review; situational diagnosis and elaboration of illustrations; layout; design and texts. A Likert scale was applied for content evaluation. The data were analyzed using Cronbach's alpha coefficient, Content Validity Index, and level of agreement. Results The definition of the theme was based on the demands perceived in the situational diagnosis and literature review. The selection of images was made through photographs, image banks, and Illustrator. The information was built as a comic book with the help of a graphic designer. The technology, evaluated by 12 health professionals, showed a satisfactory level of reliability according to Cronbach's alpha coefficient (0.7121). The Content Validity Index (0.875) and the level of agreement (91.67) were classified as high. Conclusion this study presented relevant considerations in promoting care and increasing the scope of possibilities of health professional interventions from the perspective of child- and family-centered care.


Subject(s)
Humans , Male , Female , Child , Adult , Health Education , Educational Technology , Diabetes Mellitus, Type 1 , Self Care , Learning
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