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1.
Rev. enferm. UERJ ; 28: e52728, jan.-dez. 2020.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1146306

ABSTRACT

Objetivo: avaliar as atividades de autocuidado em pacientes com Diabetes Mellitus tipo 2. Método: estudo transversal que incluiu 40 pacientes. Aplicou-se 2 instrumentos para coleta de dados: questionário sociodemográfico e questionário de atividades de autocuidado com o diabetes, aplicados entre janeiro e março de 2020. Resultados: a menor pontuação foi para o item "Realizar exercício físico específico (nadar, caminhar, etc)", com média 0,6 (DP=1,54) dias por semana, e a maior para o item "Tomar medicamentos conforme recomendados (insulina ou comprimidos)" com média 5,1 (DP=2,74) dias por semana. Quanto ao tabagismo, 92,5% referiram não ter fumado cigarro nos últimos sete dias. Conclusão: as atividades de autocuidado prevalentes relacionaram-se as intervenções farmacológicas, enquanto os cuidados não farmacológicos, incluindo a alimentação e realização de exercícios físicos, foram menos frequentes.


Objective: to evaluate self-care activities in patients with type-2 Diabetes Mellitus. Method: this cross-sectional study included 40 patients. Two instruments ­ a sociodemographic questionnaire and a questionnaire on diabetes self-care activities ­ were applied between January and March 2020. Results: the item "Perform specific physical exercise (swimming, walking, etc.)" scored lowest, averaging 0.6 (SD = 1.54) days a week, and "Taking medications as recommended (insulin or pills)" scored highest, with mean 5.1 (SD = 2.74) days a week. 92.5% reported not having smoked cigarettes in the prior seven days. Conclusion: selfcare activities relating to pharmacological interventions predominated, while non-pharmacological care, including food and physical exercise, was less frequent.


Objetivo: evaluar las actividades de autocuidado en pacientes con Diabetes Mellitus tipo 2. Método: este estudio transversal incluyó a 40 pacientes. Se aplicaron dos instrumentos, un cuestionario sociodemográfico y un cuestionario sobre actividades de autocuidado de la diabetes, entre enero y marzo de 2020. Resultados: el ítem "Realizar ejercicio físico específico (nadar, caminar, etc.)" obtuvo la puntuación más baja, con una media de 0,6 (DE = 1,54) días a la semana, y "Tomar los medicamentos según lo recomendado (insulina o píldoras)" obtuvo la puntuación más alta, con una media de 5,1 (DE = 2,74) días a la semana. El 92,5% informó no haber fumado cigarrillos en los siete días anteriores. Conclusión: predominaron las actividades de autocuidado relacionadas con las intervenciones farmacológicas, mientras que la atención no farmacológica, incluida la alimentación y el ejercicio físico, fue menos frecuente.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Self Care , Diabetes Mellitus, Type 2/therapy , Brazil , Cross-Sectional Studies , Data Collection , Surveys and Questionnaires , Family Health Strategy , Diabetes Mellitus, Type 2/prevention & control
2.
REME rev. min. enferm ; 24: e-1279, fev.2020.
Article in Portuguese | LILACS, BDENF | ID: biblio-1051306

ABSTRACT

Objetivo: verificar a associação entre a adesão ao tratamento medicamentoso e não medicamentoso e as práticas assistenciais prestadas às pessoas com diabetes Mellitus tipo 2 (DM2) pelas equipes da Estratégia Saúde da Família (ESF). Método: estudo transversal, do tipo inquérito domiciliar, realizado com pessoas com DM2 cadastradas nas 65 equipes urbanas da ESF, selecionadas aleatoriamente e de forma estratificada por equipe. Os dados foram coletados no primeiro semestre 2014 mediante entrevista estruturada e na análise, usando-se regressão logística, considerando-se associação significativa quando p≤0,05. Resultados: as 408 pessoas participantes tinham idade média de 66,5 anos, 84,1% relataram aderir ao tratamento medicamentoso, 29,4% realizavam atividade física regularmente e 24% tinham alimentação adequada. Após ajustes, as variáveis que permaneceram associadas ao tratamento medicamentoso foram: não participação em atividade de educação em saúde (p=0,012) e ser atendido pelo mesmo enfermeiro (p=0,048). Em relação ao medicamentoso, a adoção de alimentação adequada apresentou associação com verificação trimestral da glicemia capilar (p=0,011) e ser questionado, durante o atendimento, sobre a prática de atividade física (p=0,012) e a prática de atividade física regular com participação em atividades de educação em saúde (p=0,031), estar satisfeito com a assistência (p=0,04), ser atendido no mesmo dia em que procurou a UBS (p=0,017) e os profissionais perguntarem sobre sua saúde (p=0,011). Conclusão: as pessoas com DM2 apresentaram boa adesão ao tratamento medicamentoso e baixa adesão ao não medicamentoso, indicando que as equipes da ESF precisam ampliar a implementação de ações de promoção da saúde, prevenção e controle da doença e suas complicações.(AU)


Objective: to verify the association between adherence to medication and nonmedication treatment and the care practices provided to people with type 2 diabetes Mellitus (DM2) by the Family Health Strategy (ESF) teams. Method: cross-sectional study, of the household survey type, carried out with people with DM2 registered in the 65 urban teams of the ESF, randomly selected and stratified by team. Data were collected in the first semester of 2014 through a structured interview and in the analysis, using logistic regression, considering a significant association when p≤0.05. Results: the 408 people participating had an average age of 66.5 years, 84.1% reported adhering to drug treatment, 29.4% performed regular physical activity and 24% had adequate nutrition. After adjustments, the variables that remained associated with drug treatment were non-participation in health education activities (p=0.012) and being attended by the...(AU)


Objetivo: verificar la asociación entre la adhesión al tratamiento con medicación y sin medicación y las prácticas de atención de los equipos de la Estrategia de salud familiar (ESF) a las personas con diabetes Mellitus tipo 2 (DM2). Método: estudio transversal, tipo encuesta domiciliaria, realizado con personas con DM2 inscritas en los 65 equipos urbanos de la ESF, seleccionados al azar y estratificados por equipo. Los datos se recogieron el primer semestre de 2014 a través de una entrevista estructurada y durante el análisis, utilizando regresión logística, considerando la asociación significativa cuando p≤0.05. Resultados: las 408 personas que participaron tenían edad promedio de 66,5 años; el 84,1% indicó adhesión al tratamiento farmacológico; el 29,4% realizó actividad física regular y el 24% tenía nutrición adecuada. Después de los ajustes, las variables que permanecieron asociadas con el tratamiento farmacológico fueron: la no participación en actividades de educación para la salud (p = 0,012) y atención del mismo enfermero (p = 0,048). Con respecto a la medicación, la adopción de la alimentación adecuada se asoció con el control trimestral de la glucemia capilar (p = 0,011) y que le preguntasen, mientras lo atendían, sobre la práctica de actividad física (p = 0,012) y la práctica de actividad física regular con participación en actividades de educación para la salud (p = 0,031), estar satisfecho con la atención brindada (p = 0,04), ser atendido el mismo día que fue a la UBS (p = 0,017) y que los profesionales preguntasen sobre su salud (p = 0,011). Conclusión: las personas con DM2 mostraron buena adhesión al tratamiento con medicación y baja adhesión al tratamiento sin medicación, lo que indica que los equipos de ESF deben ampliar la implementación de acciones para promover la salud, prevenir y controlar la enfermedad y sus complicaciones.(AU)


Subject(s)
Humans , Aged , Primary Health Care , Diabetes Mellitus , Diabetes Mellitus, Type 2/prevention & control , Treatment Adherence and Compliance , Family Health Strategy , Health Promotion
5.
J. appl. oral sci ; 28: e20190248, 2020. graf
Article in English | LILACS, BBO | ID: biblio-1056591

ABSTRACT

Abstract The evidence is inconclusive regarding the effect of periodontal treatment on glycemic control and systemic inflammation in patients with type 2 diabetes (T2D) and periodontitis Objective: To evaluate the effect of scaling and root planing (SRP) on the metabolic control and systemic inflammation of patients with type 2 diabetes (T2D). Methodology: A literature search was conducted using the MEDLINE database via PubMed and the Cochrane Central Register of Controlled Trials, from their oldest records up to July 2018. Only randomized clinical trials (RCT) were considered eligible for evaluating the effect of periodontal treatment on markers of metabolic control [glycated hemoglobin (HbA1C)] and systemic inflammation [C-reactive protein (CRP)] in patients with T2D. The quality of the studies was evaluated using the Cochrane Collaboration risk assessment tool. Meta-analyses were performed for HbA1c and CRP using random effects models. The size of the overall intervention effect was estimated by calculating the weighted average of the differences in means (DM) between the groups in each study. Heterogeneity was assessed using the Q-statistic method (x2 and I²). The level of significance was established at p<0.05. Results: Nine RCT were included. SRP was effective in reducing HbA1c [DM=0.56 (0.36-0.75); p<0.01] and CRP [DM=1.89 (1.70-2.08); p<0.01]. No heterogeneity was detected (I2=0%, p>0.05). Conclusions: SRP has an impact on metabolic control and reduction of systemic inflammation of patients with T2D.


Subject(s)
Humans , Periodontitis/physiopathology , Periodontitis/therapy , Dental Scaling/methods , Root Planing/methods , Diabetes Mellitus, Type 2/physiopathology , Diabetes Mellitus, Type 2/prevention & control , C-Reactive Protein/analysis , Glycated Hemoglobin A/analysis , Treatment Outcome , Publication Bias
6.
J. appl. oral sci ; 28: e20190248, 2020. graf
Article in English | LILACS, BBO | ID: biblio-1090780

ABSTRACT

Abstract The evidence is inconclusive regarding the effect of periodontal treatment on glycemic control and systemic inflammation in patients with type 2 diabetes (T2D) and periodontitis Objective: To evaluate the effect of scaling and root planing (SRP) on the metabolic control and systemic inflammation of patients with type 2 diabetes (T2D). Methodology: A literature search was conducted using the MEDLINE database via PubMed and the Cochrane Central Register of Controlled Trials, from their oldest records up to July 2018. Only randomized clinical trials (RCT) were considered eligible for evaluating the effect of periodontal treatment on markers of metabolic control [glycated hemoglobin (HbA1C)] and systemic inflammation [C-reactive protein (CRP)] in patients with T2D. The quality of the studies was evaluated using the Cochrane Collaboration risk assessment tool. Meta-analyses were performed for HbA1c and CRP using random effects models. The size of the overall intervention effect was estimated by calculating the weighted average of the differences in means (DM) between the groups in each study. Heterogeneity was assessed using the Q-statistic method (x2 and I²). The level of significance was established at p<0.05. Results: Nine RCT were included. SRP was effective in reducing HbA1c [DM=0.56 (0.36-0.75); p<0.01] and CRP [DM=1.89 (1.70-2.08); p<0.01]. No heterogeneity was detected (I2=0%, p>0.05). Conclusions: SRP has an impact on metabolic control and reduction of systemic inflammation of patients with T2D.


Subject(s)
Humans , Periodontitis/physiopathology , Periodontitis/therapy , Dental Scaling/methods , Root Planing/methods , Diabetes Mellitus, Type 2/physiopathology , Diabetes Mellitus, Type 2/prevention & control , C-Reactive Protein/analysis , Glycated Hemoglobin A/analysis , Treatment Outcome , Publication Bias
7.
Revista Digital de Postgrado ; 9(1): e189, 2020. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1095033

ABSTRACT

Evaluar el impacto educativo en pacientes con Diabetes Mellitus tipo 2 (DMT2) e Hipertensión arterial (HTA), y su efecto en la calidad de vida. Métodos: Se realizó un estudio intervención en comunidad, en pacientes con diagnóstico de DMT2 e HTA, en la consulta de Medicina Interna. Resultados: Participaron 314 pacientes, distribuidos en un grupo estudio (n = 160) y grupo control (n = 154). Sin diferencias en edad (p = 0,491) y sexo (p = 0,747). En la calidad de vida de pacientes DM entre pre y post charla, en cada grupo, sin diferencias entre grupos en pre-charla (p = 0,869), pero sí en post-charla (p = 0,001), siendo calidad de vida más alta en el grupo estudio (98,2%) que en grupo control (76,9%). Al evaluar los cambios entre pre y post charla, se observó que pre charla en el grupo estudio tuvo 86% de alta calidad de vida, posterior aumentó a 98,2%, cambio estadístico (p = 0,008), en grupo control en cambio, la calidad de vida pre charla fue 87% pasó a 76,9% posterior a ésta, aun así, fue un cambio significativo (p = 0,025) La calidad de vida en HTA, sin diferencias en pre y post charla. La comparación entre pre charla y post charla, en el grupo estudio, no tuvo cambios (p = 0,157) como igualmente en el grupo control (p = 0,317). Conclusiones: Se demostró el impacto positivo de un plan educativo en calidad de vida de los pacientes con diabetes, mas no en pacientes hipertensos(AU)


To evaluate the educational impact in patients with Type 2 Diabetes Mellitus (T2DM) and arterial hypertension (AHT), and its effect on quality of life. Methods: A community intervention study was carried out in patients diagnosed with T2DM and HBP in the Internal Medicine department. Results: 314 patients participated, distributed in a study group (n = 160) and control group (n = 154). No differences in age (p = 0.491) and sex (p = 0.747). In the quality of life of DM patients between pre and post talk, in each group, without differences between groups in pre-talk (p = 0.869), but in post-talk (p = 0.001), with higher quality of life in the study group (98.2%) than in the control group (76.9%). When evaluating the changes between pre and post talk, it was observed that pre-talk in the study group had 86% of high quality of life, later it increased to 98.2%, statistical change (p = 0.008), in control group instead, Pre-chat quality of life was 87%, after 76.9%, it was still a significant change (p = 0.025) Quality of life in HTA, without differences in pre and post talk. The comparison between pre-talk and post-talk, in the study group, did not change (p = 0.157) as well as in the control group (p = 0.317). Conclusions: The positive impact of an educational plan on the quality of life of diabetic patients was demonstrated, but not in hypertensive patients(AU)


Subject(s)
Quality of Life , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/prevention & control , Hypertension/complications , Hypertension/diagnosis , Hypertension/prevention & control , Health Programs and Plans , Patient Education as Topic , Control Groups , Surveys and Questionnaires/statistics & numerical data , Disease Progression
8.
Cienc. enferm. (En línea) ; 26: 14, 2020. tab, graf
Article in Spanish | LILACS, BDENF | ID: biblio-1132981

ABSTRACT

RESUMEN Objetivo: Evaluar el riesgo de desarrollar Diabetes Mellitus Tipo 2 (DM2) y sus factores asociados en estudiantes de una institución universitaria de Barranquilla-Colombia. Material y Método: Se realizó un estudio correlacionai de corte transversal, en el cual se aplicó el cuestionario Finnish Diabetes Risk Score (FINDRISC) a 362 sujetos para calcular el riesgo de DM2. Se determinó glicemia en ayunas a aquellos que obtuvieron puntuación ≥12 (riesgo moderado a muy alto de desarrollar DM2) en el cuestionario. Resultados: El 12,4% de los participantes mostraron una puntuación ≥12. Se encontró asociación estadísticamente significativa entre esta puntuación y factores modificables como sedentarismo y sobrepeso/obesidad. Se detectó glicemia en ayunas alterada (100 -125 mg/dL) en el 26,67% de los sujetos testeados. Conclusiones: Este estudio presenta evidencias sobre el riesgo de DM2 y exposición a factores asociados en un colectivo de adultos mayoritariamente jóvenes. Los resultados sugieren adoptar medidas de prevención de DM2 en el grupo de estudio basadas en cambios de estilos de vida.


ABSTRACT Objective: To assess the risk of developing Diabetes Mellitus Type 2 (DM2) and its associated factors among students from a university in Barranquilla, Colombia. Materials and Methods: A cross-sectional, correlational study was conducted, in which the Finnish Diabetes Risk Score (FINDRISC) questionnaire was applied to 362 subjects in order to calculate the risk of DM2. Fasting glycemia was determined for those participants who obtained a ≥12 score (moderate to very high risk of developing DM2) in the questionnaire. Results: 12.4% of participants showed a ≥12 score. A statistically significant association was found between this score and modifiable factors such as sedentary lifestyle and overweight/obesity. Altered fasting glycemia (100 - 125 mg/dL) was detected in 26.67% of the participants. Conclusions: This study provides evidence about the risk of DM2 and exposure to associated factors in a group of mostly young adults. The results suggest adopting measures to prevent DM2 in the study group based on lifestyle changes.


RESUMO Objetivo: Avaliar o risco de desenvolver Diabetes Mellitus Tipo 2 e os seus fatores associados em estudantes de uma instituição universitária em Barranquilla-Colômbia. Materiais e Métodos: Foi realizado um estudo correlacional de corte transversal, no qual o questionário Finnish Diabetes Risk Score (FINDRISC) foi aplicado a 362 sujeitos para calcular o risco de DM2. A glicemia em jejum foi determinada para aqueles que obtiveram no questionário um escore ≥12 (risco moderado a muito alto). Resultados: 12,4% dos participantes obtiveram um escore ≥12. Foi encontrada associação estatisticamente significativa entre esse escore e fatores modificáveis, como sedentarismo e sobrepeso/obesidade. Foi detectada glicemia em jejum alterada (100 - 125 mg/dL) em 26,67% dos sujeitos testados. Conclusões: Este estudo apresenta evidências sobre o risco de DM2 e a exposição a fatores associados em um grupo de adultos, na maioria jovens. Os resultados sugerem a adoção de medidas de prevenção de DM2 no grupo de estudo com base em mudanças no estilo de vida.


Subject(s)
Humans , Male , Female , Adult , Risk Factors , Age Factors , Diabetes Mellitus, Type 2/prevention & control , Students , Colombia , Education, Higher
9.
Rev. Ciênc. Plur ; 5(2): 94-110, ago. 2019. tab
Article in Portuguese | LILACS, BBO | ID: biblio-1021764

ABSTRACT

Introdução:Diabetes Mellitus tipo 2 é uma doença crônica, silenciosa, caracterizada por hiperglicemia causada pela produção insuficiente, ou resistência a ação da insulina. No Brasil, em 2017, diagnosticou 12,5 milhões de pessoas com diabetes mellitus, com uma prevalência de 8 a 9%, ocupando o quinto lugar no mundo. Dianteda transição nutricional, várias pesquisas tem demonstrado prevalência desta patologia em crianças, adolescentes e jovens. Objetivo:Identificar o risco de desenvolver Diabetes mellitus tipo 2 nos estudantes do curso de Biomedicina, da Faculdade Unigran Capital, Campo Grande, MS. Método:Trata-se de um Estudo Epidemiológico Descritivo Quantitativo Transversal, com uma amostra de 132 estudantes, através da aplicação de um questionário, determinação de glicemia capilar, coleta do peso, altura, cintura abdominal, e aferição da pressão arterial. Resultados:Foi identificado fatores de riscos importantes nos estudantes de biomedicina: obesidade, sedentarismo, hipertensão, consumo de dieta não saudável e a predisposição genética. Os homens apresentaram mais fatores dos que as mulheres, as faixas etárias mais jovens de 18-20 anos encontravam-se mais sedentários e mais obesos, e, as faixas etárias mais velhas apresentaram hipertensão e consumo de dieta não saudável. Conclusões:Há necessidade de promover medidas de prevenção: consumo de dieta saudável e prática de atividade física entre os estudantes, para evitar o desenvolvimento desta patologia (AU).


Introduction:Type 2 Diabetes Mellitus is a chronic silent disease characterized by hyperglycemia caused by insufficient production, or resistance to the action of insulin. In Brazil, in 2017, diagnosed 12.5 million people with Diabetes Mellitus, with prevalence of 8 to9%, ranking fifth in the world. Faced with the nutritional transition, several studies have demonstrated the prevalence of this pathology in children, adolescents and young people. Objective:To identify the risk of developing Type 2 Diabetes Mellitus instudents of Biomedicine, Faculty of Unigran Capital, Campo Grande, MS.Methods:This is an Epidemiological Descriptive Cross-Sectional Study, with a sample of 132 students, through the application of a questionnaire, determination of capillary glycemia, weight, height, abdominal waist, and blood pressure measurement. Results:: Important risk factors were identified in biomedicine students: obesity, sedentary lifestyle, hypertension, consumption of unhealthy diet and genetic predisposition. Males presentedmore factors than females, the younger age groups of 18-20 years were more sedentary and more obese, and the older age groups presented hypertension and unhealthy diet consumption.Conclusions:There is a need to promote prevention measures: consumption of healthy diet and practice of physical activity among students, to avoid the development of this pathology (AU).


Subject(s)
Humans , Male , Female , Adolescent , Adult , Students, Health Occupations , Risk Factors , Diabetes Mellitus, Type 2/prevention & control , Sedentary Behavior , Brazil , Epidemiology, Descriptive , Surveys and Questionnaires , Statistics, Nonparametric
10.
Actual. osteol ; 15(2): 78-93, mayo - ago. 2019. ilus.
Article in Spanish | LILACS | ID: biblio-1048450

ABSTRACT

Los hallazgos osteológicos se intensi!caron en los últimos años. Se demostró que el esqueleto se comporta, además de sus funciones clásicas, como un órgano de secreción endocrina que sintetiza al menos dos hormonas: el factor de crecimiento de !broblastos 23 (FGF-23) y la osteocalcina (Ocn). La Ocn es un péptido pequeño que contiene 3 residuos de ácido glutámico. Estos residuos se carboxilan postraduccionalmente, quedando retenida en la matriz ósea. La forma decarboxilada en el primer residuo de ácido glutámico (GluOcn) fue reportada por poseer efectos biológicos; la resorción ósea es el mecanismo clave para su bioactivación. La presente revisión se centra en los conocimientos actuales sobre la función hormonal de la Ocn. A la fecha se reporta que la Ocn regularía el metabolismo energético aumentando la proliferación de células ` pancreáticas, y la secreción de insulina y de adiponectina. Sobre el músculo esquelético actuaría favoreciendo la absorción y el catabolismo de nutrientes. La función reproductiva masculina estaría regulada mediante el estímulo a las células de Leydig para sintetizar testosterona; en el desarrollo cerebral y la cognición, la Ocn aumentaría la síntesis de neurotransmisores monoaminados y disminuiría el neurotransmisor inhibidor GABA. Si bien son indispensables mayores evidencias para dilucidar los mecanismos reguladores por medio de los cuales actuaría la Ocn, los resultados enumerados en los distintos estudios experimentales establecen la importancia de este novedoso integrante molecular. Dilucidar su rol dentro de estos procesos interrelacionados en seres humanos abriría la posibilidad de utilizar a la Ocn en el tratamiento de enfermedades endocrino-metabólicas. (AU)


Osteological !ndings have intensi!ed in recent years. The skeleton behaves as an endocrine secretion organ that synthesizes at least two hormones: osteocalcin (Ocn) and !broblast growth factor 23 (FGF-23). Ocn is a small peptide that contains 3 glutamic acid residues. After translation, these residues are carboxylated to make possible its retention into the bone matrix. Decarboxylation on the !rst glutamic acid residue (GluOcn) has been reported to have biological effects. Bone resorption is the key mechanism for its bioactivation. This review focuses on current knowledge on Ocn hormonal function. It has been reported that Ocn regulates energy metabolism by increasing the proliferation of pancreatic ` cells, and the secretion of insulin and adiponectin. On the skeletal muscle, it may act by favoring the absorption and catabolism of nutrients. Male reproductive function might be regulated by stimulating Leydig cells to synthesize testosterone. Regarding brain development and cognition, Ocn would increase monoamine neurotransmitters synthesis and decrease inhibitory neurotransmitter GABA. Although more evidence is needed to elucidate the regulatory mechanisms of Ocn, different experimental studies establish the importance of this novel molecular mediator. Clarifying its role within interrelated processes in humans, might open the possibility of using Ocn in different treatments of endocrine-metabolic diseases. (AU)


Subject(s)
Animals , Osteocalcin/metabolism , Osteocalcin/therapeutic use , Skeleton/physiology , Skeleton/metabolism , Skeleton/pathology , Warfarin/therapeutic use , Cardiovascular Diseases/prevention & control , Osteocalcin/biosynthesis , Osteocalcin/chemistry , Diabetes Mellitus, Type 2/prevention & control , Endocrine System Diseases/therapy , Energy Metabolism/physiology , Insulin-Secreting Cells/physiology , Fertility , Fibroblast Growth Factors/metabolism , Genitalia, Male/metabolism , Infertility/prevention & control , Metabolic Diseases/therapy , Neoplasms/prevention & control
12.
Rev. méd. Chile ; 147(4): 480-489, abr. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1014250

ABSTRACT

Physical training is recommended in several studies and guidelines for the control of type 2 diabetes mellitus (DM2) and its complications. We performed a systematic review about the effects of aerobic training (AT), resistance (RT) or the combination of both (AT/ RT), on glycated hemoglobin (HbA1c) in patients with DM2. Therefore, we included 15 clinical trials with at least 12 weeks duration about training program or recommendations of physical exercise, that evaluated the reduction in HbA1c levels in patients with DM2. Information was obtained on training modality (AT, RT or AT / RT), training parameters, duration and weekly training frequency. The results showed increases in peak or maximal oxygen uptake, exercise tolerance time and muscle strength, depending on the type of training, and a reduction in HbA1c levels. We conclude that exercise training is associated with reductions of HbA1c in patients with DM2. Thus, it can be a complementary tool in the management of these patients.


Subject(s)
Humans , Diabetes Mellitus, Type 2/physiopathology , Diabetes Mellitus, Type 2/prevention & control , Resistance Training/methods , Physical Conditioning, Human/methods , Time Factors , Glycated Hemoglobin A/analysis , Reproducibility of Results , Treatment Outcome , Diabetes Mellitus, Type 2/metabolism , Physical Conditioning, Human/physiology
14.
Rev. pesqui. cuid. fundam. (Online) ; 11(1): 199-204, jan.-mar. 2019. tab.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-968473

ABSTRACT

Objetivo: Evaluar la calidad de vida relacionada con la salud de las personas con diabetes mellitus tipo 2 servido por el Primaria de la Salud. Métodos: Estudio descriptivo transversal realizado con 50 pacientes diabéticos. Los datos fueron recolectados a través de la aplicación de un formulario de información socioeconómica y clínica y el estudio de resultados médicos de 36 preguntas Short Form Health Survey (SF-36). Los datos se expresaron como frecuencias absolutas y relativas y tendencia central y medidas de dispersión. Resultados: El promedio más alto de las puntuaciones del SF-36 fueron encontrados en las áreas de "capacidad funcional, vitalidad y aspectos sociales", mientras que las más bajas se concentraron en las zonas "estado general de salud y la apariencia física". Conclusión: La funcionalidad de las actividades diarias y la percepción de la salud fueron los principales factores cometidos por la diabetes mellitus tipo 2


Objetivo: Avaliar a qualidade de vida relacionada à saúde de pessoas com diabetes mellitus tipo 2 atendidas pela Atenção Primária à Saúde. Método: Estudo descritivo, transversal realizado com 50 pacientes diabéticos. Os dados foram coletados por meio da aplicação de um formulário para informações socioeconômicas e clínicas e do Medical Outcomes Study 36-item Short Form Health Survey (SF-36). Os dados foram expressos como frequências absolutas e relativas e medidas de tendência central e dispersão. Resultados: As maiores médias dos escores do SF-36 foram verificadas nos domínios "Capacidade Funcional, Vitalidade e Aspectos Sociais", enquanto as menores concentraram-se nos domínios "Estado Geral da Saúde e Aspecto Físico". Conclusão: A funcionalidade das atividades diárias e a percepção sobre a saúde foram os principais aspectos comprometidos pelo diabetes mellitus tipo 2


Objective: To evaluate the quality of life related to health of people with type 2 diabetes mellitus served by Primary Health. Methods: Descriptive transversal study performed with 50 diabetic patients. Data were collected through the application of a form for socioeconomic and clinical information and the Medical Outcomes Study 36-item Short Form Health Survey (SF-36). Data were expressed as absolute and relative frequencies and central tendency and dispersion steps. Results: The highest average of the SF-36 scores were found in the areas "Functional Capacity, Vitality and Social Aspects", while the lowest were concentrated in areas "General State of Health and Physical Appearance." Conclusion: The functionality of daily activities and perception of health were the main factors committed by the type 2 diabetes mellitus


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Sickness Impact Profile , Diabetes Mellitus, Type 2/nursing , Diabetes Mellitus, Type 2/prevention & control , Primary Health Care
15.
São Paulo; s.n; s.n; 2019. 67 p. tab, graf, ilus.
Thesis in Portuguese | LILACS | ID: biblio-1049424

ABSTRACT

O treinamento físico aeróbio (TFA) tem sido cada vez mais recomendado para a prevenção e tratamento de comorbidades, que podem ter em comum a resistência periférica à insulina (RI), como o diabetes tipo 2 (DM2) ea obesidade. Caracterizada pelo acúmulo excessivo de tecido adiposo, a obesidade também implica a disfunção endócrina desse tecido. Leptina e adiponectina são hormônios secretados pelos adipócitos que desempenham importante função no metabolismo energético, cujo desequilíbrio está fortemente relacionado à obesidade e à RI. Fisiologicamente, mulheres apresentam maiores níveis de leptina e adiponectina comparados aos de homens. Contudo, em condições como a obesidade e/ou DM2 esses níveis diminuem, deixando o organismo de fêmeas sem os efeitos protetores dessas adipocinas. Assim, o presente estudo teve como objetivo investigar os efeitos do TFA sobre as características morfofuncionais de TAB e pâncreas de camundongos fêmeas com deficiência de leptina. Para isso, camundongos fêmeas com oitosemanas de idade C57BL/J6 selvagem (C57) ou com deficiência de leptina ob/ob (Lepob) foram separadas nos grupos sedentárias (S) e treinadas (T): C57S (n=6), C57T (n=6), LepobS (n=5) e LepobT (n=8). O TFA foi realizadodurante oito semanas, com corrida a 60% da capacidade máxima, 1h/dia, 5x/semana. Água e ração foram administradas ad libitum. Os procedimentos foram aprovados pelo CEUA da EACH-USP (#001/2017). O acompanhamento do peso corporal e consumo de ração foi realizado semanalmente. Na 7ª semana de protocolo foram realizados os testesde tolerância àglicose (TTG) e à insulina (TTI). Ao final do protocolode treinamento foram avaliados parâmetros metabólicos de repouso e de esforço através da calorimetria indireta. A eutanásia dos animais foi realizada cominjeção intraperitoneal de anestésico e, em seguida, foram coletados os tecidos adiposos branco (TAB) subcutâneo e retroperitoneal e a porção esplênica do pâncreas, utilizados, posteriormente, para análises morfológicas. A determinação de adiponectinasérica foi realizada através de kit ELISA. Os resultados foram analisados por ANOVA de duas vias mais o teste post-hoc de Bonferroni. O protocolo de TFA não foi eficaz em reduzir a adiposidade e hiperfagia dos animais LepobS e LepobT, contudo o grupo LepobT apresentou tamanho reduzido de adipócitos doTAB-SC comparado ao grupo LepobS.O TFA não afetouo metabolismo glicêmico dos animais. Os parâmetros metabólicos derepouso não apresentaram alteração, contudo, noteste de esforço físico máximo, o grupo LepobT apresentou maiores tempo em teste até a exaustão e iVO2 comparado ao grupo LepobS. Por fim, embora o TFA não tenha aumentadoa secreção de adiponectina, o que poderia regular positivamente o metabolismo glicêmico de camundongos deficientes em leptina, melhorou a condição metabólica desses animais e reduziu a hipertrofia dos adipócitos do TAB-SC


Aerobic physical training (APT) has become an important strategy for the prevention and treatment of comorbidities, which may have in common the peripheral resistance to insulin(RI), such as type 2 diabetes and obesity. Characterized by the excessive accumulation of adipose tissue, obesity also implies endocrine dysfunction of this tissue.Leptin and adiponectin are hormones secreted by adipocytes that play an important role in energy metabolism, whose imbalance is strongly related to obesity and RI. Physiologically, women have higher levels of leptin and adiponectin compared to men.However,in conditions such as obesity and/or type 2 diabetes these levels decrease, leaving the body of females without the protective effects of these adipokines.Thus, the present study aimed to investigate the effects of APTon the morphofunctional characteristics of white adipose tissue (WAT)and pancreas in leptin-deficientfemale mice. For this, 8-week-old wild C57BL/J6 (C57) or leptin-deficient ob/ob (Lepob) female mice were separated into the groups sedentary (S) and trained (T): C57S (n = 6), C57T (n = 6), LepobS (n = 5) and LepobT (n = 8). Mice were housed in a temperature-controlled (22 ± 2°C) and 12-h light/12-h dark cycle, with free access to tap water and food ad libitum. The APT was performed for 1 h/day at 60% of maximal velocity achieved in the running capacity test, five times per week for eight weeks. The procedures were performed in accordance with the guidelines of the Brazilian College for Animal Experimentation and were approved by the Ethics Committee of the School of Arts, Sciences and Humanities of University of Sao Paulo (Process number001/2017). Body weight and feed intake were evaluated weekly. In the 7th week of protocol, the glucose and insulin tolerance tests (GTT and ITT) were performed. At the end of the training protocol, metabolic parameters of resting and maximal exertion were evaluated through indirect calorimetry. The euthanasia of the animals was performed by intraperitoneal injection of anaesthetic and thenthe subcutaneous and retroperitoneal WAT and the splenic portion of the pancreas were collected, and subsequentlyused for morphological analysis. Serum adiponectin quantification was performed by ELISA kit. The results were analyzed by two-way ANOVA plus the Bonferroni post-hoc test. The APT protocol was not effective in reducing the adiposity and hyperphagia of the animals LepobS and LepobT, however the LepobT group presented a reduced size of WAT-SC adipocytes compared to the LepobS group. Also, APT did not affectthe glycemic metabolism of theseanimals. Although the resting metabolic parameters were not different, in the maximal physical exercise test, the LepobT group had longer time to exhaustion test and iVO2 compared to the LepobS group.Finally, although APTdid not increase adiponectin plasma concentration, which could positively regulate the glycemic metabolism of leptin-deficient mice, it improved the metabolic condition of these animals and reduced the adipocyte hypertrophy of WAT-SC


Subject(s)
Animals , Female , Mice , Exercise/physiology , Leptin/deficiency , Insulin Resistance , Diabetes Mellitus, Type 2/prevention & control , Obesity/prevention & control
16.
Rev. latinoam. enferm. (Online) ; 27: e3161, 2019. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1014207

ABSTRACT

Objetivo: identificar o risco de desenvolvimento de diabetes tipo 2 em enfermeiras e sua relação com as alterações metabólicas. Método: estudo transversal, com 155 enfermeiras. As variáveis investigadas foram: sociodemográficas, índice de massa corporal, a circunferência da cintura, índice cintura-quadril, perfil lipídico, a glicemia basal e a curva oral de tolerância à glicose. Para a coleta de dados utilizou-se o Finnish Diabetes Risk Score. Resultados: Das 155 (100%) enfermeiras, a média de idade foi de 44 anos e 85% apresentavam sobrepeso ou obesidade; 52% tinham história familiar de diabetes e 21%, hiperglicemia ocasional. Em relação ao risco, 59% foram identificados com risco moderado e muito alto de diabetes tipo 2. A glicose, a insulina, a hemoglobina glicosilada A1c e a resistência à insulina aumentaram paralelamente ao aumento do risco de diabetes tipo 2, embora os lipídios não tenham aumentado. 27% das participantes apresentaram glicemia em jejum alterada, 15%, intolerância à glicose e 5%, diabetes tipo 2. Conclusão: houve uma elevada taxa de detecção de risco de diabetes tipo 2 (59%) e a pontuação de risco alto e muito alto foi associado com níveis elevados de hemoglobina glicosilada A1c, glicose, insulina e resistência à insulina, mas não com lipídios.


Objective: to detect the risk of development of type 2 diabetes in nurses and its relationship with metabolic alterations. Method: cross-sectional study, with 155 nurses. The variables investigated were: sociodemographic, body mass index, waist circumference, waist-hip index, lipid profile, basal glycemia and oral glucose tolerance curve. The Finnish Diabetes Risk Score was used to collect data. Results: 155 nurses were included, with an average age of 44 years and 85% were overweight or obese. 52% had a family history of diabetes and 21% had occasional hyperglycemia. With respect to the risk, 59% were identified with moderate and very high risk for type 2 diabetes. Glucose, insulin, glycosylated hemoglobin A1c and insulin resistance increased in parallel to the increased risk for type 2 diabetes, although lipids did not increase. 27% of the sample had impaired fasting glycemia. 15% had glucose intolerance and 5% had type 2 diabetes. Conclusion: there was a high detection rate of people at risk for type 2 diabetes (59%) and the high and very high risk score was associated with high levels of glycosylated hemoglobin A1c, glucose, insulin and insulin resistance, but not with lipids.


Objetivo: identificar el riesgo de desarrollo de diabetes tipo 2 en enfermeras y su relación con alteraciones metabólicas. Método: estudio transversal, con 155 enfermeras. Las variables investigadas fueron: sociodemográficas, el índice de masa corporal, circunferencia de cintura, índice cintura-cadera, perfil de lípidos, glucemia basal y curva de tolerancia oral a la glucosa. Para la recolección de datos se utilizó el Finnish Diabetes Risk Score. Resultados: De las 155 enfermeras, la edad promedio fue 44 años y 85% tenía sobrepeso u obesidad. El 52% tenía antecedentes familiares de diabetes de primera línea, el 21% hiperglucemia ocasional. Con relación al riesgo, se identificaron 59% con riesgo de diabetes tipo 2 moderado y muy alto. Glucosa, insulina, hemoglobina glucosa A1c y la resistencia a la insulina incrementaron paralelos al aumento del riesgo de diabetes tipo 2, aunque los lípidos no. El 27% de las enfermeras presentó glucemia basal alterada. El 15% tuvo intolerancia a la glucosa y 5% diabetes tipo 2. Conclusión: la detección de riesgo de diabetes tipo 2 fue elevada (59%) y el puntaje de riesgo alto y muy alto se relacionó con valores mayores de hemoglobina glucosa A1c, glucosa, insulina y resistencia a la insulina pero no con lípidos.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Prediabetic State/complications , Prediabetic State/prevention & control , Body Mass Index , Diabetes Mellitus, Type 2/ethnology , Diabetes Mellitus, Type 2/prevention & control , Overweight/complications , Hyperglycemia/diagnosis , Obesity/complications , Socioeconomic Factors , Insulin Resistance , Cross-Sectional Studies , Surveys and Questionnaires , Mexico
18.
Rev. Hosp. Ital. B. Aires (2004) ; 38(2): 62-69, jun. 2018. graf.
Article in Spanish | LILACS | ID: biblio-1023082

ABSTRACT

Objetivo: conocer e interpretar las representaciones sociales que tienen las personas con diabetes mellitus (DM) tipo 2 en una comunidad de bajo nivel socioeconómico del Gran Buenos Aires. Metodología: investigación cualitativa, tipo estudio de caso. Se realizaron entrevistas semiestructuradas a personas con diagnóstico de DM tipo 2, atendidas en un centro de atención primaria del Bajo Boulogne, partido de San Isidro, Buenos Aires. Mediante un muestreo teórico o por conveniencia, a partir de las historias clínicas generadas entre enero de 2001 y julio de 2017. Se incluyeron personas con diagnóstico reciente y otras con más de 15 años de evolución, hasta la saturación del discurso. Se realizó un análisis temático. Resultados: se realizaron 20 entrevistas. La mayoría de las personas entrevistadas tenían entre 60 y 69 años y eran de sexo femenino. La DM es vivida como una enfermedad que no tiene cura y que no condiciona a quienes la padecen en lo cotidiano. No impresionó ser una carga, excepto para las personas insulinizadas, quienes le asignan una connotación negativa a esa terapia. No encontramos diferencias de acuerdo con el sexo, la edad o los años de evolución. Los entrevistados asociaron la DM con malos hábitos alimentarios y escasa o nula actividad física. Conclusiones: en esta comunidad, la DM es vivida con naturalidad, en especial por quienes llevan años padeciéndola. La red familiar constituye la principal fuente de apoyo, acompañamiento, contención y provisión de cuidados. No se identificaron otras redes además de la familia o el sistema médico tradicional. (AU)


Objective: to recognize and to understand the social representations of people with type 2 diabetes mellitus (DM) in a community with a low socioeconomic level of suburban Buenos Aires. Methods: qualitative research, case study type. Semi-structured interviews were administered to people diagnosed with type 2 DM, who attended a primary care center in Bajo Boulogne, San Isidro district, Buenos Aires. Through a theoretical or convenience sampling, from the clinical records generated between January 2001 and July 2017. We included people with a recent diagnosis and others with more than 15 years of evolution, until speech saturation. We carried out a thematic analysis. Results: we conducted 20 interviews. Most of the people were aged between 60 and 69 years and were female. DM is lived as a disease without a cure and which does not condition the daily activities of people who suffer from it. It did not impress to be a burden, except for insulinized people, who assigned a negative connotation to that therapy. We did not find differences according to sex, age or years of evolution. Patients associated DM with poor eating habits and little or no physical activity. Conclusions: in this community, DM is lived naturally, especially by those who have been suffering from it for years. The family network constitutes the main source of support, accompaniment, containment, and provision of care. No other networks were identified, besides the family or the traditional medical system. (AU)


Subject(s)
Humans , Male , Female , Middle Aged , Aged , Self Care/psychology , Social Perception , Diabetes Mellitus, Type 2/epidemiology , Preventive Health Services/trends , Social Change , Social Class , Social Environment , Social Medicine , Evaluation Studies as Topic/statistics & numerical data , Health-Disease Process , Public Health/education , Chronic Disease/psychology , Surveys and Questionnaires , Diabetes Mellitus, Type 2/prevention & control , Diabetes Mellitus, Type 2/psychology , Diabetes Mellitus, Type 2/therapy , Family Practice , Feeding Behavior , Sedentary Behavior , Treatment Adherence and Compliance , Health Promotion/trends
19.
Acta cir. bras ; 33(6): 542-550, June 2018. tab, graf
Article in English | LILACS | ID: biblio-949355

ABSTRACT

Abstract Purpose: To evaluate the effects of 1,25 dihydroxy vitamin D3 (1,25(OH)2D3) on the content of triglyceride (TG), as well as on the gene and protein expressions of adiponectin receptor 2 (AdipoR2), p38 mitogen-activated protein kinase (P38MAPK), and lipoprotein lipase (LPL) in the liver of rats with type 2 diabetes mellitus (T2DM) so as to provide theoretical basis for exploring the mechanism by which 1,25(OH)2D3 regulates TG. Methods: Wistar rats were divided into four groups (n=25), with different treatments and detected the gene and protein expressions of AdipoR2, p38MAPK, and LPL in the liver tissue by reverse transcription polymerase chain reaction (RT-PCR) and Western blotting. Meanwhile, the content of TG in the liver tissue was detected by the Enzyme-linked immunosorbent assay. Results: The expression of AdipoR2, p38MAPK, LPL gene and protein in the liver of VitD intervention group was significantly higher than that in T2DM group (P <0.05), while the TG content was significantly lower than that in T2DM group (P <0.05). Conclusion: 1,25(OH)2D3 can decrease the content of TG in the liver, and its mechanism may be achieved by upregulating the expressions of AdipoR2, p38MAPK, and LPL in the liver.


Subject(s)
Animals , Male , Triglycerides/blood , Calcitriol/pharmacology , Diabetes Mellitus, Type 2/metabolism , Liver/drug effects , Liver/metabolism , Reference Values , Blood Glucose/analysis , Body Weight , Enzyme-Linked Immunosorbent Assay , Gene Expression , Up-Regulation , Blotting, Western , Reproducibility of Results , Rats, Wistar , Reverse Transcriptase Polymerase Chain Reaction , p38 Mitogen-Activated Protein Kinases/analysis , p38 Mitogen-Activated Protein Kinases/drug effects , Diabetes Mellitus, Type 2/prevention & control , Receptors, Adiponectin/analysis , Receptors, Adiponectin/drug effects , Lipoprotein Lipase/analysis , Lipoprotein Lipase/drug effects
20.
Article in Portuguese | LILACS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-909290

ABSTRACT

A doença ateromatosa carotídea é responsável por até 15% de todos os acidentes vasculares cerebrais (AVC). O diabetes é um dos fatores de risco cardiovasculares mais importantes para o início e progressão da aterosclerose carotídea. O controle precoce do diabetes e dos demais fatores de risco cardiovasculares concomitantes constituem-se na intervenção mais custo-efetiva para prevenir o AVC nesses casos. O tratamento clínico, atualmente, é considerado como primeira escolha para os pacientes com estenoses carotídeas assintomáticas. Entretanto, nos pacientes com estenoses sintomáticas superiores a 70%, a endarterectomia apresenta alto impacto no desfecho cardiovascular. O procedimento endovascular com stent com filtro para neuroproteção é uma opção quando a cirurgia convencional não é possível.


Carotid atheromatous disease is responsible for up to 15% of all strokes. Diabetes is one of the most important cardiovascular risk factors for the onset and progression of carotid atherosclerosis. Early control of diabetes and other concomitant cardiovascular risk factors is the most cost-effective intervention to prevent stroke in these cases. Clinical treatment is currently considered the first choice for patients with asymptomatic carotid stenoses. However, in patients with symptomatic stenosis with more than 70% of obstruction, endarterectomy has a high impact on the cardiovascular outcome. The endovascular procedure with stent with filter for neuroprotection is a good option when conventional surgery is not possible.


Subject(s)
Coronary Artery Disease/physiopathology , Carotid Stenosis/diagnostic imaging , Stroke/history , Diabetes Mellitus, Type 2/prevention & control , Risk Factors , Endovascular Procedures/rehabilitation
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