ABSTRACT
Introducción. La pandemia por COVID-19 afectó la atención de pacientes con diabetes mellitus tipo 1 (DM1). Además, se reportó un aumento de cetoacidosis diabética (CAD) como forma de diagnóstico. Objetivos. Evaluar si durante la pandemia por COVID-19 se modificaron el tiempo de evolución de síntomas, las causas de hospitalización por DM1 y la proporción de formas graves, y describir la infección por SARS-CoV-2 en estos pacientes. Población y métodos. Estudio transversal que incluyó pacientes menores de 19 años hospitalizados por DM1 en un centro pediátrico de referencia de marzo de 2018 a agosto de 2019 (prepandemia) y de marzo de 2020 a agosto de 2021 (pandemia). Resultados. Se analizaron 231 internaciones, 135 prepandemia y 96 en pandemia. Los pacientes con debut diabético presentaron menor tiempo de evolución de síntomas en pandemia que en prepandemia (18,8 ± 10,2 vs. 52,1 ±12,1 días, respectivamente; p <0,001). Las hospitalizaciones por todas las formas de debut diabético y el debut con CAD fueron más frecuentes en pandemia que en prepandemia (59,4 % vs. 39,3 %; OR 2,3; IC95% 1,3-3,8; p = 0,003); y (40,6 % vs. 20,7 %; OR 2,6; IC95% 1,4-5,2; p = 0,006) respectivamente. La proporción de formas graves de CAD no se modificó entre ambos períodos (48,1 % vs. 59,9 %; p = 0,3). Solo 6 pacientes presentaron infección por SARS-CoV-2; 3 fueron formas graves. Conclusión. Durante la pandemia, disminuyó el tiempo de evolución de síntomas y aumentó la frecuencia de hospitalizaciones por debut de DM1, con mayor proporción de CAD. No se modificó la proporción de formas graves de CAD
Introduction. The COVID-19 pandemic impacted on the health care of patients with type 1 diabetes mellitus (DM1). An increase in diabetic ketoacidosis (DKA) as a form of diagnosis was reported. Objectives. To assess whether there were changes in the time from symptom onset, the causes of hospitalization due to DM1, and the proportion of severe forms, and to describe SARS-CoV-2 infection in these patients. Population and methods. Cross-sectional study in patients younger than 19 years hospitalized due to DM1 from March 2018 to August 2019 (pre-pandemic) and from March 2020 to August 2021 (pandemic). Results. The assessment included 135 hospitalizations in the pre-pandemic period and 96 during the pandemic. The time from symptom onset during the pandemic in those with debutof diabetes was shorter than in the pre-pandemic period (18.8 ± 10.2 versus 52.1 ± 12.1 days, respectively; p < 0.001). Hospitalizations due to all forms of diabetes debut and debut with DKA were more common during the pandemic than before it (59.4% versus 39.3%; odds ratio [OR]: 2.3; 95% confidence interval [CI]: 1.33.8; p = 0.003 and 40.6% versus 20.7%; OR: 2.6; 95% CI: 1.45.2; p = 0.006, respectively). Severe forms of DKA did not change between both periods (48.1% versus 59.9%; p = 0.3). Only 6 patients developed SARS-CoV-2 infection; 3 were severe. Conclusion. During the pandemic, the time from symptom onset decreased and the frequency of hospitalizations due to debut of DM1 increased. The proportion of severe forms of DKA did not change.
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Diabetic Ketoacidosis/diagnosis , Diabetic Ketoacidosis/epidemiology , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/epidemiology , COVID-19/diagnosis , COVID-19/epidemiology , Hospitalization/statistics & numerical data , Time Factors , Cross-Sectional StudiesABSTRACT
Introduction. Diabetes mellitus is one of the most common diseases worldwide, with a high morbidity and mortality rate. Its prevalence has been increasing, as well as its acute complications, such as hyperglycemic crises. Hyperglycemic crises can present with combined features of diabetic ketoacidosis and hyperosmolar state. However, their implications are not fully understood. Objective. To describe the characteristics, outcomes, and complications of the diabetic population with hyperglycemic crises and to value the combined state in the Latin American population. Materials and methods. Retrospective observational study of all hyperglycemic crises treated in the intensive care unit of the Fundación Valle del Lili between January 1, 2015, and December 31, 2020. Descriptive analysis and prevalence ratio estimation for deaths were performed using the robust Poisson regression method. Results. There were 317 patients with confirmed hyperglycemic crises, 43 (13.56%) with diabetic ketoacidosis, 9 (2.83%) in hyperosmolar state, and 265 (83.59%) with combined diabetic ketoacidosis and hyperosmolar state. Infection was the most frequent triggering cause (52.52%). Fatalities due to ketoacidosis occurred in four patients (9.30%) and combined diabetic ketoacidosis/hyperosmolar state in 22 patients (8.30%); no patient had a hyperosmolar state. Mechanical ventilation was associated with death occurrence (adjusted PR = 1.15; 95 % CI 95 = 1.06 - 1.24). Conclusions. The combined state was the most prevalent presentation of the hyperglycemic crisis, with a mortality rate similar to diabetic ketoacidosis. Invasive mechanical ventilation was associated with a higher occurrence of death.
Introducción. La diabetes mellitus es una de las enfermedades más frecuentes en todo el mundo, con una tasa elevada de morbimortalidad. Su prevalencia ha ido en aumento y, también, sus complicaciones agudas, como las crisis hiperglucémicas. Las crisis hiperglucémicas pueden presentar características combinadas de cetoacidosis diabética y estado hiperosmolar. Aún no se conocen completamente sus implicaciones. Objetivo. Describir las características, los resultados y las complicaciones de la población diabética con crisis hiperglucémicas, y valorar el estado mixto en la población latinoamericana. Materiales y métodos. Se trata de un estudio observacional retrospectivo de pacientes con crisis hiperglucémicas atendidos en la unidad de cuidados intensivos de la Fundación Valle del Lili, entre el 1° de enero de 2015 y el 31 de diciembre de 2020. Se realizó un análisis descriptivo y se estimó la razón de prevalencia para muerte mediante el método de regresión de Poisson. Resultados. Se incluyeron 317 pacientes con crisis hiperglucémica confirmada, 43 (13,56 %) con cetoacidosis diabética, 9 (2,83 %) en estado hiperosmolar y 265 (83,59 %) en estado mixto. La causa desencadenante más frecuente fue la infección (52,52 %). Cuatro pacientes fallecieron por cetoacidosis (9,30 %), 22 (8,30 %), por un estado mixto; ninguno se encontraba en estado hiperosmolar. La asistencia respiratoria mecánica se asoció con la muerte (razón de prevalencia ajustada = 1,15; IC95%: 1,06-1,24). Conclusiones. El estado combinado fue la presentación más prevalente de la crisis hiperglucémica, con una tasa de mortalidad similar a la de la cetoacidosis diabética, y la asistencia respiratoria mecánica invasiva se asoció con una mayor ocurrencia de muerte.
Subject(s)
Humans , Diabetic Ketoacidosis , Diabetes Mellitus , Hyperglycemia , Mortality , Latin AmericaABSTRACT
@#The occurrence of hyperuricemia is frequently associated with diabetic ketoacidosis (DKA), however, crystalluria from the precipitation of calcium oxalate, uric acid, or urate crystals, is less known. Metabolic derangements during DKA, especially acidic urinary pH and hyperuricosuria are the main risk factors for uric acid crystals and stones. Here we report a case of uric acid crystalluria following the recovery phase of DKA.
Subject(s)
Crystalluria , Uric Acid , Diabetic KetoacidosisABSTRACT
Objectives@#This study aims to determine the effect of the COVID-19 pandemic on the incidence, severity, and outcome of children diagnosed with diabetic ketoacidosis admitted in a tertiary pediatric hospital.@*Materials and Methods@#Two groups were identified as the basis for classification: pre-pandemic (2017 to 2019) and COVID-19 pandemic (2020 to 2022). The Mann‐Whitney U test was utilized to test for the differences in continuous variables, while Pearson’s chi‐squared test was used to test for differences in categorical variables.@*Results@#The study involved 136 participants, 63 of whom were recorded in the pre-pandemic period and 73 during the COVID-19 pandemic period. Data revealed no conclusive relationship between sex (p=0.578), age (p=0.225), or height (p=0.876) across the two time frames. However, data showed significant difference between the weight (p=0.007) and BMI (p=0.003) of children with DKA pre-pandemic and during pandemic. This implies that marked changes in weight and BMI reflect possible changes in health behaviors, healthcare access, or other variables that may have altered during the COVID-19 pandemic. Furthermore, there was no discernible difference between pre-pandemic and COVID-19 in terms of severity, incidence, or the amount of time between the onset of symptoms and consultation.@*Conclusion@#The demographic and clinical characteristics of patients with DKA across the two study periods indicate a degree of stability in patient profiles. Despite the unique circumstances of the pandemic, patient outcomes in terms of glycemic control and mortality were like those observed pre-pandemic. The significant difference in weight and BMI emphasizes how crucial it is to monitor and respond to modifications in the nutritional status and metabolic health of DKA patients during times of crisis, like the COVID-19 pandemic. Comprehending these changes can provide focused treatments aimed at promoting the best possible health outcomes for susceptible patient groups.
Subject(s)
Diabetic Ketoacidosis , Diabetes Mellitus , COVID-19ABSTRACT
Objective:to identify the knowledge and attitudes of school-agedchildren with diabetes facing acute complications.Method:exploratory study design with a qualitative approach, which used puppets as a data collection strategy. Children aged between seven and 12-years having experience with the disease for at least oneyear, followed-up at a Childhood Outpatient Clinic from Santa Catarina, Brazil, were interviewed. Analysis followed deductive content analysis. Results:participants demonstrated poor management of hyperglycemia episodes which could prevent diabetic ketoacidosis. The knowledge about hypoglycemia is higher due to its frequency; however, it has been the result of a deficient self-care with poor adult supervision. Conclusions:lack of understanding and inadequate management was evidenced, in especial, during the hyperglycemia and when the children are away from their parents. The nurses should promote education to immediate actions in acute complications. Educational materials focused on these clientele will contribute to enhance knowledge and abilities.
Objetivo:identificar conhecimentos e atitudes de crianças escolares com diabetes tipo 1 frente complicações agudas da doença. Método:estudo exploratório, qualitativo, que utilizou fantoches como estratégia de coleta de dados. Crianças entre 7 e 12 anos, com pelo menos um ano de diagnóstico, seguidas em ambulatório infantil de Santa Catarina, Brasil, foram entrevistadas. Análise de conteúdo dedutiva foi realizada. Resultados:participantes demonstraram pobre conhecimento e manejo dos episódios de hiperglicemia, o que poderia prevenir a cetoacidose diabética. Os conhecimentos sobre hipoglicemia são maiores, pois ocorrem com frequência, porém têm sido resultado de autocuidado deficiente com pobre supervisão de adultos. Conclusões:falta de entendimento e manejo inadequado das complicações foi evidenciado, em especial na hiperglicemia e quando longe dos cuidadores. O enfermeiro deve promover educação de crianças e famílias para ações imediatas e efetivas perante complicações agudas. Materiais educativos, direcionados a esta clientela, contribuirão para maior conhecimento e desenvolvimento de habilidades.
Objetivo:identificar conocimientos y actitudes de escolares con diabetes tipo 1 frente a las complicaciones agudas de la enfermedad. Método:estudio cualitativo exploratorio que utilizó títeres y fueron entrevistados niños entre 7 y 12 años, con al menos un año de diagnóstico, en una clínica infantil en Santa Catarina, Brasil. Se realizó un análisis de contenido. Resultados:hayescaso conocimiento y manejo de los episodios de hiperglucemia, lo que podría prevenir la cetoacidosis diabética. El conocimiento sobre la hipoglucemia es mayor, ya que ocurre con frecuencia, pero ha sido el resultado de un autocuidado deficiente con una supervisión adulta deficiente. Conclusiones:falta comprensión y manejo adecuado de las complicaciones, especialmente en la hiperglucemia y cuando está lejos de los cuidadores. El enfermero debe promover la educación de los niños y las familias para acciones inmediatas y eficaces frente a las complicaciones agudas. Los materiales educativoscontribuirán a esto.
Subject(s)
Diabetes Mellitus, Type 1 , Pediatric Nursing , Diabetic Ketoacidosis , Qualitative Research , HypoglycemiaABSTRACT
Introducción: Según numerosos reportes, la pandemia por COVID19 aumentó la incidencia de diabetes tipo 1 (DBT1) y cetoacidosis (CAD). Nuestro objetivo fue describir la frecuencia de nuevos casos de DBT1 y su severidad al ingreso en el Hospital J. P. Garrahan durante la pandemia, comparando con el periodo anterior. Material y métodos: Se realizó un estudio descriptivo, observacional, con análisis retrospectivo. Se incluyeron todos los nuevos casos entre 19/03/20- 31/12/21, comparados con el período 19/03/18-31/12/19. El diagnóstico de DBT1, CAD y su severidad se realizó según la International Society for Pediatric and Adolescent Diabetes. Se analizó el requerimiento de cuidados intensivos (UCI), presencia de COVID-19, hemoglobina glicosilada A1C (HbA1C) y autoanticuerpos (GADA, IAA, IA2, ZNT8). Se consideró significativa una p < 0,05. Resultados: En el período 2020-2021 se observó un incremento del 107% de nuevos casos, ingresando 56 pacientes con DBT1. La media y mediana de edad disminuyeron (8 vs 9,1 y 7,7 vs 10,4, respectivamente), con un incremento del 35% de menores de 5 años. Aumentó la frecuencia de CAD severa (41.1% vs 25.9%) y de requerimiento de UCI (17.9% vs 11.1%). La Hb A1C y la glucemia de ingreso mostraron incremento significativo (10.1% vs 12.32%, p<0.003 y 580 mg/dl ± 220 vs 490 mg/dl ± 188; p<0.05, respectivamente). Conclusión: En 2020-2021 se incrementó el número de nuevos casos de DBT1 en nuestra institución. Al ingreso hubo mayor proporción de niños pequeños y casos severos. Las dificultades de acceso a la consulta de atención primaria podrían relacionarse con nuestro hallazgo (AU)
Introduction: Numerous reports have shown that during the COVID-19 pandemic the incidence of type-1 diabetes (T1DB) and ketoacidosis (DKA) increased. The aim of this study was to describe the frequency of new cases and their severity on admission of T1DB at Hospital J. P. Garrahan during the pandemic, compared with the previous period. Material and methods: A descriptive, observational study with a retrospective analysis was conducted. All new cases seen between 19/03/20-31/12/21 were included and compared with the period 19/03/18-31/12/19. The diagnosis of T1DB, DKA, and its severity was made according to the International Society for Pediatric and Adolescent Diabetes. Intensive care (ICU) requirement, presence of COVID-19, glycosylated hemoglobin A1C (HbA1C), and autoantibodies (GADA, IAA, IA2, ZNT8) were analyzed. A p < 0.05 was considered significant. Results: In the period 2020-2021, a 107% increase in new cases was observed including 56 patients with T1DB. Mean and median age decreased (8 vs 9.1 and 7.7 vs 10.4, respectively), with a 35% increase in children under 5 years of age. The frequency of severe DKA (41.1% vs 25.9%) and ICU requirement (17.9% vs 11.1%) increased. Hb A1C and glycemia on admission also showed a significant increase (10.1% vs 12.32%, p<0.003 and 580 mg/dl ± 220 vs 490 mg/dl ± 188; p<0.05, respectively). Conclusion: In 2020-2021 an increase in the number of new cases of T1DB was observed at our institution. On admission, a higher rate of young children and severe cases was found. Difficulties to access primary care may have been related to our finding (AU)
Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Diabetic Ketoacidosis/epidemiology , Diabetes Mellitus, Type 1/epidemiology , COVID-19/epidemiology , Hospitals, Pediatric , Severity of Illness Index , Incidence , Retrospective StudiesABSTRACT
Objective@#This study aims to characterize the presentation, biochemical status of children with T1DM at diagnosis, the type of subcutaneous insulin regimens initiated, and to determine the incidence of T1DM in Bruneian children aged 18 years and younger.@*Methodology@#A retrospective electronic and paper medical chart review was performed on patients aged 18 years and younger diagnosed with T1DM from 2013 to 2018 in Brunei Darussalam.@*Results@#A total of 31 children with a mean age of 10.2 ± 3.6 years old were diagnosed with T1DM, of which 66.7% presented with diabetic ketoacidosis (DKA), a majority in severe DKA with an intercurrent illness (p=0.021). The mean HbA1c was 13.6 ± 2.7% with a mean serum glucose of 37.0±14.9 mmol/L at diagnosis. In the majority of the children (67.7%), multiple daily injections of subcutaneous insulin were initiated. The incidence of T1DM in children aged 18 years and younger was 4.9 per 100,000 for the year 2018.@*Conclusions@#The majority of the patients in this study presented with severe DKA with an intercurrent illness. This highlights the importance of childhood T1DM awareness among the public and healthcare providers. The incidence of childhood T1DM in Brunei Darussalam is similar to other countries in the Asian region, being relatively low, compared to the rest of the world.
Subject(s)
Diabetes Mellitus, Type 1 , Diabetic KetoacidosisABSTRACT
Background: Diabetic ketoacidosis (DKA) remains an important cause of hospitalisation and death in people with diabetes mellitus (DM) living in low- and middle-income countries. The clinical profile of patients with DKA varies, and maybe contributory to the outcomes observed globally. The aim of this study was to describe the clinical characteristics of people with diabetic ketoacidosis (DKA) seen at a clinic in The Gambia during a one-and-a-half-year period. Methods: This was a retrospective chart review that included people with DM who were seen from June 2017 to December 2018 at the Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine. Biodata, anthropometric and admissions data were extracted for all patients from the electronic medical records system. Data were analysed for differences in clinical and biochemical characteristics on admission for DKA. Results: In total, 23 out of 103 admissions for people with DM were for a diagnosis of DKA during the study period. Sixteen of those included were females and the mean age of all patients was 35 ± 13 years. Two people had type 1 DM and 15 people were categorised as type 2 DM. DM was diagnosed for the first time during admission for DKA for 12 people and 6 people had confirmed sepsis. There were no significant differences in age at diagnosis of DM or biochemical characteristics. Conclusion: DKA was a common indication for admission for people with DM in the Medical Research Council the Gambia at London School of Hygiene and Tropical Medicine and the majority of patients with DKA had type 2 DM. Further studies are needed to describe DKA in this setting more accurately.
Subject(s)
Prevalence , Retrospective Studies , Diabetic Ketoacidosis , Sepsis , Biomedical Research , Diabetes Mellitus , Diagnosis , Schools , MethodsABSTRACT
Pouco se sabe sobre a atuação do psicólogo no Brasil junto a pessoas com Diabetes Mellitus. O objetivo desta pesquisa foi identificar os psicólogos brasileiros que trabalham com essa população e suas ações. Foram convidados a responder a um questionário online psicólogos que atuam ou atuaram junto a pessoas com diabetes. Participaram 79 psicólogos, principalmente da região Sudeste (59,5%). Todos declararam que haviam cursado pósgraduação. Na amostra, predominou o gênero feminino (89,9%), com idade entre 26 e 40 anos (46,8%). A maioria dos que atuam com diabetes declarou-se autônoma ou voluntária, e quase metade trabalhava menos do que 10 horas semanais. Entre aqueles que deixaram de trabalhar com diabetes, apenas uma minoria tinha vínculo empregatício. Além do trabalho com pessoas com diabetes, a maior parte declarou exercer outras atividades profissionais, como atendimentos clínicos em consultórios particulares, sugerindo que esta não é a atividade principal. Majoritariamente, os respondentes declararam não ter conhecimentos suficientes para o atendimento específico às pessoas com diabetes. Discute-se a qualidade da formação profissional dos psicólogos no Brasil, a necessidade de aprimoramento em relação à atuação com pessoas com diabetes e as condições de trabalho.(AU)
Little is known about the practice of psychologists in Brazil caring for people with Diabetes Mellitus. The aim of this research was to identify the Brazilian psychologists who work with this population and describe their actions. Psychologists who work or have worked with people diagnosed with diabetes were invited to answer an online questionnaire. The 79 participants lived mainly in the Southeast Region (59.5%). All of them declared to have a graduate degree, most were female (89.9%), aged 26 to 40 years (46.8%). Most of those working with diabetes declared to be autonomous or voluntary, and almost half had a workload of less than 10 hours a week. Among those who stopped working with diabetes, only a minority had a formal employment contract. In addition, most of them stated that they had other professional activities related to clinical care in private offices, suggesting that working with diabetes is not their main activity. Mostly, respondents stated that they did not have enough knowledge to care for people with diabetes. The quality of professional education of psychologists in Brazil, the need for specific improvement in labor relations and conditions were discussed.(AU)
Son escasas las informaciones del trabajo de los psicólogos en Brasil con las personas con Diabetes Mellitus. El objetivo de este estudio fue identificar los psicólogos brasileños que trabajan con esta población y describir sus acciones. Se invitó a psicólogos que trabajan o hayan trabajado con personas con diabetes a responder un cuestionario en línea. Participaron 79 psicólogos, principalmente de la región Sureste de Brasil (59,5%). Todos declararon tener posgrado. En la muestra hubo una mayor prevalencia del género femenino (89,9%), de edades de entre 26 y 40 años (46,8%). La mayoría de los que trabajan con personas con diabetes se declararon autónomos o voluntarios, y casi la mitad trabajaba menos de 10 horas a la semana. Entre los que dejaron de trabajar con las personas con diabetes, solo una minoría tenía una relación laboral. Además de trabajar con personas con diabetes, la mayoría afirmó tener otras actividades profesionales, como la atención clínica en consultorios privados, lo que sugiere que esta no es su actividad principal. La mayoría de los encuestados afirmaron que no tenían los conocimientos suficientes para atender específicamente a las personas con diabetes. Se discuten la calidad de la formación profesional de los psicólogos en Brasil, la necesidad de mejora en relación con el trabajo con personas con diabetes y las condiciones laborales.(AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Psychology , Acting Out , Diabetes Mellitus , Professional Training , Anxiety , Pain , Patient Care Team , Primary Health Care , Public Policy , Quality of Life , Research Personnel , Self Care , Self-Care Units , Self Concept , Social Sciences , Autoimmune Diseases , Specialization , Stress, Psychological , Therapeutics , Transplantation , Volunteers , Wound Healing , Behavior , Body Composition , Adaptation, Psychological , Pharmaceutical Preparations , Exercise , Weight Loss , Family , Patient Acceptance of Health Care , Blindness , Cholesterol , Mental Health , Disease Outbreaks , Episode of Care , Diabetic Ketoacidosis , Cost of Illness , Continuity of Patient Care , Counseling , Universal Access to Health Care Services , Crisis Intervention , Health Law , Death , Diabetes Complications , Depression , Diabetes Mellitus, Type 1 , Diabetes Mellitus, Type 2 , Diabetic Angiopathies , Diagnosis , Dialysis , Emergencies , Disease Prevention , Bariatric Surgery , Fear , Binge-Eating Disorder , Epidemics , Chronic Pain , Insulins , Cognitive Dysfunction , Problem Behavior , Diet, Healthy , Global Burden of Disease , Treatment Adherence and Compliance , Access to Essential Medicines and Health Technologies , Burnout, Psychological , Self-Neglect , Sadness , Diabulimia , Psychological Distress , Transtheoretical Model , Psychosocial Intervention , Glycemic Control , Sociodemographic Factors , Psychological Well-Being , Food, Processed , Health Promotion , Health Services Accessibility , Amputation, Surgical , Hospitalization , Hyperglycemia , Hypoglycemia , Kidney Failure, Chronic , Life Style , Mental Disorders , Metabolism , Nutritional and Metabolic Diseases , ObesityABSTRACT
Los inhibidores de checkpoint (ICP) son anticuerpos usados en inmunoterapia contra el cáncer. Uno de sus blancos de acción es el receptor de muerte celular programada-1 (PD-1), el cual es importante para mantener la tolerancia inmunitaria. Sin embargo, este mecanismo se asocia a riesgo de eventos adversos relacionados a la inmunidad que pueden afectar a múltiples órganos incluyendo el sistema endocrino. Se describe el caso inhabitual de un paciente que a los 18 meses de terapia con ICP debutó con cetoacidosis diabética (CAD).
Immune checkpoint inhibitors consist in antibodies used in immunotherapy against cancer. One of their targets is the programmed cell death-1 (PD-1) receptor, which is important in maintaining self-tolerance. However, this mechanism is associated with a risk for immune-related adverse events potentially affecting multiple organs, including the endocrine system. We describe the unusual case of a patient who, after 18 months of treatment with an immune checkpoint inhibitor, debuted with diabetic ketoacidosis
Subject(s)
Humans , Male , Middle Aged , Diabetic Ketoacidosis/chemically induced , Antibodies, Monoclonal, Humanized/adverse effects , Immune Checkpoint Inhibitors/adverse effects , Skin Neoplasms/drug therapy , Diabetic Ketoacidosis/immunology , Diabetes Mellitus/chemically induced , Cell Cycle Checkpoints , Antineoplastic Agents, Immunological/adverse effects , Immunotherapy/adverse effects , Melanoma/drug therapyABSTRACT
Las emergencias hiperglicémicas como la cetoacidosis diabética (CAD) y el síndrome hiperglicémico hiperosmolar (SHH) se han descrito en el contexto de infección por SARS-CoV-2, como también secundarias a las múltiples vacunas desarrolladas contra el virus. La fisiopatología que explicaría esta asociación aún no está clara, pero existen diversas teorías que incluyen la destrucción directa de los islotes pancreáticos por el virus o secundario a mecanismos inmuno-inflamatorios. Presentamos el caso de un paciente que debutó con CAD al tercer día de la primera dosis de CoronaVac, y que posteriormente presentó hiperglicemia sin cumplir criterios de CAD luego de la segunda y tercera dosis de CoronaVac y Pfizer respectivamente. La temporalidad, como la falta de gatillante y la evolución del cuadro, apuntan a la vacuna como el principal precipitante. Por lo anterior, es importante mantener una vigilancia estricta de los efectos adversos de las vacunas y educar sobre los síntomas sugerentes de una crisis hiperglicémica para pesquisarla a tiempo y actuar oportunamente.
Hyperglycemic emergencies such as diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic syndrome (HHS) have been reported in SARS-CoV-2 infections and after vaccination. The pathophysiology behind this association is still unclear, several theories have been described that include the direct destruction of the pancreatic islets by the virus, and some immuno-inflammatory mechanisms. We present the case of a patient who develope DKA the third day after the first dose of CoronaVac vaccine, and then hypergycemia after the second and third dose of CoronaVac and Pfizer repectively. The temporal relation, lack of a trigger and evolution of the disease, point the vaccine as the main precipitant. The strict surveillance of vaccines adverse effects and education of symptoms suggestive of hyperglicemic emergency are critical to prevent and treat promptly this kind of situations.
Subject(s)
Humans , Male , Middle Aged , Diabetic Ketoacidosis/chemically induced , COVID-19 Vaccines/adverse effects , SARS-CoV-2 , Hyperglycemia/chemically inducedABSTRACT
Objetivo: Descrever as práticas realizadas por enfermeiros no manejo ao paciente crítico com cetoacidose diabética (CAD). Método: Revisão integrativa de literatura realizada entre maio e junho de 2022 nas bases: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), Banco de Dados de Enfermagem (BDENF) e Medical Literature Analysis and Retrievel System Online (MEDLINE/PubMed). Foram selecionados para esta revisão 08 artigos. Resultados: Os resultados apontam que o enfermeiro deve estar atento aos sinais e sintomas dos fatores precipitantes causadores da CAD e, entre os portadores, promover ações para o seu controle, por intermédio de medidas como monitoramento da glicemia e o desenvolvimento de atividades educativas para o autocuidado. Este profissional deve manter a observação de forma contínua durante o tratamento. Conclusão: A cetoacidose é uma emergência glicêmica no qual torna-se necessário que o profissional de enfermagem tenha conhecimentos fundamentais a respeito dos sinais e sintomas da CAD.(AU)
Objective: To describe the practices performed by nurses in the management of critically ill patients with diabetic ketoacidosis (DKA). Method: Integrative literature review carried out between May and June 2022 in the following bases: Latin American and Caribbean Literature in Health Sciences (LILACS), Scientific Electronic Library Online (SciELO), Nursing Database (BDENF) and Medical Literature Analysis and Retrievable System Online (MEDLINE/PubMed). Eight articles were selected for this review. Results: The results indicate that nurses should be aware of the signs and symptoms of precipitating factors that cause CAD and, among patients, promote actions for its control, through measures such as blood glucose monitoring and the development of educational activities for the self care. This professional must maintain continuous observation during treatment. Conclusion: Ketoacidosis is a glycemic emergency in which it is necessary for the nursing professional to have fundamental knowledge about the signs and symptoms of DKA.(AU)
Objetivo: Describir las prácticas realizadas por enfermeros en el manejo de pacientes críticos con cetoacidosis diabética (CAD). Método: Revisión integrativa de la literatura realizada entre mayo y junio de 2022 en las siguientes bases de datos: Literatura Latinoamericana y del Caribe en Ciencias de la Salud (LILACS), Biblioteca Científica Electrónica en Línea (SciELO), Base de Datos de Enfermería (BDENF) y Sistema de Análisis y Recuperación de Literatura Médica en Línea (MEDLINE/ PubMed). Se seleccionaron ocho artículos para esta revisión. Resultados: Los resultados indican que los enfermeros deben ser conscientes de los signos y síntomas de los factores precipitantes que causan la EAC y, entre los pacientes, promover acciones para su control, a través de medidas como el monitoreo de la glucosa en sangre y el desarrollo de actividades educativas para el autocuidado. Este profesional debe mantener observación continua durante el tratamiento. Conclusión: La cetoacidosis es una emergencia glucémica en la que es necesario que el profesional de enfermería tenga conocimientos fundamentales sobre los signos y síntomas de la CAD.(AU)
Subject(s)
Diabetic Ketoacidosis , Critical Care , Nursing CareABSTRACT
Introducción: en diciembre de 2019 se inició una epidemia por coronavirus SARS-CoV-2, causante de un síndrome de dificultad respiratoria que, posteriormente, se denomina enfermedad COVID-19y que es probable afecta menos a los niños que a los adultos. En Cuba existen aproximadamente 15,246 contagiados menores de 19 años. La diabetes mellitus tipo 1 (DM1) asociada al COVID-19puede representar peligro para la vida del paciente. Objetivo: determinar algunas características de la COVID-19en la población pediátrica estudiada con diabetes mellitus tipo 1 durante el primer año de inicio de la pandemia en Cuba. Método: se seleccionaron al azar los servicios de endocrinología pediátrica de las provincias: Ciego de Ávila, Villa Clara, Pinar del Río y en La Habana (Hospitales Pediátricos Cerro y Centro Habana). Se solicitó cuántos pacientes durante el primer año de la pandemia (marzo 2020-marzo 2021) debutaron con DM1, cuántos en cetosis/cetoacidosis. Estos datos se compararon con el año 2019. Se investigó cuantos niños DM1 ingresaron con Covid 19. Resultados: existió incremento (57.3 %) de los pacientes con debut de DM1 durante el primer año de la pandemia en comparación con 2019. La presencia de cetosis/cetoacidosis aumentó (58.2 %). Se detectó cuatro pacientes con Covid 19 y DM1, (frecuencia baja: 0, 53 %). Conclusiones: el incremento de la DM1 y de cetosis/cetoacidosis pudiera estar relacionado indirectamente con la pandemia por Covid 19, ya sea por stress, confinamiento, alimentación inadecuada o la combinación de estos factores, es prudente tener un seguimiento a mediano y largo plazo de estos pacientes.
Introduction: On December 2019, an epidemic due to the SARS-CoV-2 coronavirus began, causing a respiratory distress syndrome, later it is called the COVID-19disease, it probably affects children less than adults. In Cuba, there are approximately 15,246 infected persons under 19 years of age. Type 1 diabetes mellitus (DM1) associated with COVID-19can be life-threatening. Objective: To determine some characteristics of COVID-19in the pediatric population studied with type 1 diabetes mellitus during the first year of the onset of the pandemic in Cuba. Method: The pediatric endocrinology services of the provinces: Ciego de Ávila, Villa Clara, Pinar del Río and Havana (Hospital Pediátricos Cerro and Centro Habana) were randomly selected. It was requested how many patients during the first year of the pandemic (March 2020-March 2021) debuted with DM1, how many in ketosis / ketoacidosis. These data were compared with 2019. It was investigated how many T1D children were admitted with Covid 19. Results: There was an increase (57.3%) in patients with T1D debut during the first year of the pandemic compared to 2019. The presence of ketosis / ketoacidosis increased (58.2 %). 4 patients with Covid 19 and DM1 were detected (low frequency: 0.53%). Conclusions: The increase in DM1 and ketosis/ketoacidosis could be indirectly related to the Covid 19 pandemic, whether due to stress, confinement, inadequate nutrition or a combination of these factors, it is prudent to have a medium and long-term follow-up of these patients.
Subject(s)
Humans , Child , Adolescent , Diabetes Mellitus, Type 1 , COVID-19 , Diabetic Ketoacidosis , CubaABSTRACT
ABSTRACT We assess the severity and frequency of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes mellitus (T1D) patients and in patients with previous diagnosis of T1D in a referral Brazilian university hospital in the first five months of the COVID-19 pandemic. We also compare the data with data from pre-pandemic periods. Forty-three new-onset T1D patients were diagnosed between April and August of the years 2017, 2018, 2019, and 2020. During the COVID-19 pandemic, the number of new-onset T1D was over twice the number of new-onset T1D in the same period in the three previous years. All the 43 patients survived and are now on outpatient follow-up. We also compared the characteristics of the T1D patients hospitalized between April and August of the years 2017, 2018, and 2019 (32 hospitalizations) to the characteristics of the T1D patients hospitalized between April and August/2020 (35 hospitalizations; 1 patient was hospitalized twice in this period). Fourteen of the 34 patients admitted during the pandemic presented with COVID-19-related symptoms (any respiratory symptom, fever, nausea, vomiting, and diarrhea), but only one had positive SARS-CoV-2 RT-PCR test. Samples from 32 out of these 34 patients were assayed for SARS-CoV-2 antibodies, and four patients were positive for total antibodies (IgM and IgG). In agreement with recent reports from European countries, we observed increased frequency of DKA and severe DKA in new-onset and previously diagnosed T1D children and adolescents in a large referral public hospital in Brazil in the first five months of the COVID-19 pandemic. The reasons for this outcome might have been fear of SARS-CoV-2 infection in emergency settings, the more limited availability of primary healthcare, and the lack of school personnel's attention toward children's general well-being.
Subject(s)
Humans , Child , Adolescent , Diabetic Ketoacidosis/epidemiology , Diabetes Mellitus, Type 1/epidemiology , COVID-19/epidemiology , Brazil/epidemiology , Pandemics , SARS-CoV-2ABSTRACT
ABSTRACT Insulin antibodies (IAs) induced by exogenous insulin rarely cause hypoglycemia. However, insulin autoantibodies (IAAs) in insulin autoimmune syndrome (IAS) can cause hypoglycemia. The typical manifestations of IAS are fasting or postprandial hypoglycemia, elevated insulin level, decreased C-peptide levels, and positive IAA. We report a 45-year-old male with type 1 diabetes mellitus (T1DM) treated with insulin analogues suffering from recurrent hypoglycemic coma and diabetic ketoacidosis (DKA). His symptoms were caused by exogenous insulin and were similar to IAS. A possible reason was that exogenous insulin induced IA. IA titers were 61.95% (normal: 300 mU/L and < 0.02 nmol/L when hypoglycemia occurred. Based on his clinical symptoms and other examinations, he was diagnosed with hyperinsulinemic hypoglycemia caused by IA. His symptoms improved after changing insulin regimens from insulin lispro plus insulin detemir to recombinant human insulin (Gensulin R) and starting prednisone.
Los anticuerpos contra la insulina (AI) inducidos por la insulina exógena raramente causan hipoglucemia. No obstante, los autoanticuerpos contra la insulina (AIA) en el síndrome autoinmune de insulina (SAI) pueden causar hipoglucemia. Las manifestaciones típicas del SAI son la hipoglucemia en ayunas o posprandial, niveles elevados de insulina, la disminución del nivel de péptido C y AIA positivos. Presentamos un paciente hombre de 45 años con diabetes mellitus de tipo 1 (DMT1) tratado con análogos de insulina, que sufría comas hipoglucémicos recurrentes y cetoacidosis diabética (CAD). Sus síntomas fueron causados por la insulina exógena y fueron similares al SAI. La posible razón fue que la insulina exógena indujo AI. El título de AI era del 61,95% (Normal: 300 mU/L y < 0,02 nmol/L cuando se producía la hipoglucemia. Basados en sus síntomas clínicos y otros exámenes, se le diagnosticó hipoglucemia hiperinsulinémica causada por la AI. Sus síntomas mejoraron después de cambiar el régimen de insulina de lispro más insulina detemir a insulina humana recombinante (Gensulin R) y de empezar a tomar prednisona.
Subject(s)
Humans , Male , Middle Aged , Autoimmune Diseases/diagnosis , Diabetic Ketoacidosis/complications , Diabetic Ketoacidosis/chemically induced , Diabetic Ketoacidosis/drug therapy , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/drug therapy , Hypoglycemia/chemically induced , C-Peptide/therapeutic use , Coma , Hypoglycemic Agents/adverse effects , Insulin/therapeutic use , Insulin Antibodies/therapeutic useABSTRACT
Background: Type 1 diabetes mellitus (T1DM) is a common autoimmune disorder that often presents in children.In these patients, diabetic ketoacidosis (DKA) is one of the most common and serious acute complications, which is associated with significant morbidity and mortality. The study aimed to assess the clinical profiles and outcomes of children admitted with DKA. Objective: To assess the clinical manifestations and treatment outcomes of DKA patients in two tertiary hospitals in Addis Ababa. Methods: A hospital-based retrospective analysis was conducted on 175 pediatric diabetic ketoacidosis children,who were admitted to the emergency units of two hospitals in Addis Ababa from September 2015 to February 2020 and whose medical records contained complete pertinent data. Patients were between the ages of 0 to 12 years. Proportional samples were taken from each hospital and data was collected retrospectively using a formatted checklist. The data was checked for its inclusiveness and entered Epi Info. version 4.6 and then transferred into SPSS version 25 software for further analysis. Result: DKA was the presenting manifestation of Diabetes in 78.3% of patients and 21.7% were already known cases of Diabetes. Half (50.9%) of the study participants were diagnosed with DKA in the age range of 5 to 10 years and almost one-third (30.9%) were above the age of 10. A high-income level of the caretakers was found to be protective against DKA during the diagnosis of T1DM. Out of the 175 children admitted, 12 passed on, resulting in a mortality rate of 6.9%. Conclusion: The majority of the known DM patients presented with DKA after the omission of insulin and a newly diagnosed T1DM at first presentation. The age of presentation and clinical symptoms of the studied participants were like other international studies. Community education regarding the signs and symptoms of childhood DM can further prevent the development of DKA. [Ethiop. J. Health Dev. 2022; 36(2):000-000]
Subject(s)
Humans , Male , Female , Child , Diabetic Ketoacidosis , Therapeutics , Precipitating Factors , Treatment Outcome , Diabetes Mellitus , HospitalsABSTRACT
Type 1 diabetes mellitus(T1DM)is a common autoimmune disorder that often presents in children. In these patients, diabetic ketoacidosis(DKA)is one of the most common and serious acute complications, which isassociated with significant morbidity and mortality. The study aimed to assess the clinical profilesand outcomesof children admitted with DKA.Objective:To assess the clinical manifestationsand treatment outcomesof DKA patients in two tertiary hospitals in Addis Ababa. Methods: A hospital-based retrospective analysis was conductedon175 pediatric diabetic ketoacidosis children, who wereadmitted to the emergency units of two hospitalsin Addis Ababafrom September 2015 to February 2020andwhose medical records contained complete pertinent data. Patients were between theages of0 to 12 years.Proportional samples were taken from each hospitaland data wascollected retrospectively using a formatted checklist. The data waschecked for its inclusiveness and enteredEpi Info. version4.6 andthen transferred into SPSS version 25 software for further analysis. Result:DKA was the presenting manifestation of Diabetes in 78.3% of patients and 21.7% were already known cases of Diabetes. Half (50.9%) of the study participants were diagnosed with DKA in the age range of 5 to 10 years and almost one-third (30.9%) were abovethe age of 10. A high-incomelevel of the caretakers wasfound to be protective against DKA during thediagnosis of T1DM. Out of the 175 children admitted, 12 passed on, resulting ina mortality rate of 6.9%.Conclusion: The majority of the known DM patients presented with DKA after the omission of insulin and a newly diagnosed T1DMat first presentation.The age of presentation and clinical symptoms of the studied participantswere likeother international studies. Community education regardingthe signs and symptoms of childhood DM can further prevent the development of DKA.[Ethiop. J. Health Dev. 2022; 36(2):000-000]Keywords: Diabetic ketoacidosis, Treatment outcome, and precipitating factors
Subject(s)
Diabetic Ketoacidosis , Child Mortality , Diabetes Mellitus, Type 1 , Pediatric Obesity , Signs and Symptoms , Precipitating Factors , MorbidityABSTRACT
Coronavirus disease 2019 (COVID-19) is associated with an increased prevalence and mortality from diabetic ketoacidosis (DKA) globally. With limited access to specialised care, most patients with DKA in South Africa are managed at district hospital level. This study describes the profile of patients admitted to a district hospital in South Africa with DKA and COVID-19 and examines associated risk factors encountered. Methods: This was a case series of all patients presenting to a district hospital with DKA and COVID-19 infection between July 2020 and July 2021. Data extracted included patients' demographic profiles, biochemical results, comorbidities and clinical outcomes. Results: The median age of the 10 patients admitted during the study period was 39 years old (±12), six of whom were male. The hemoglobin A1c (HbA1c) values on admission ranged from 9.7 to 13.8. Five of the patients had pre-existing type 2 diabetes mellitus (DM). Four of the known DM patients were on metformin only, and one was on biphasic insulin. Three patients had other pre-existing comorbidities, two patients with hypertension and one with human immunodeficiency virus (HIV). Three patients demised, two of whom were hypoxic on admission. Conclusion: Diabetic ketoacidosis appears more commonly in COVID-19 infected patients with type 2 DM and at a young age. Suboptimal glycaemic control was associated with DKA, and hypoxia was a strong predictor for mortality. Treatment inertia was evident in the known DM group, who were on monotherapy despite persistent hyperglycaemia. Greater vigilance is required to detect ketosis in type 2 DM and intensify therapy to improve glycaemic control.
Subject(s)
Diabetic Ketoacidosis , Diabetes Mellitus , Glycemic Control , COVID-19 , Patients , Hospitals, DistrictABSTRACT
Objectif. L'étude visait à évaluer les aspects cliniques et thérapeutiques des enfants diabétiques suivis à l'hôpital régional de Ngaoundéré. Méthodes. Il s'agissait d'une étude transversale rétrospective descriptive conduite du 15 avril au 10 juillet 2021 à l'unité Changing Diabetes In Children (CDIC) de l'Hôpital Régional de Ngaoundéré. Les données sociodémographiques (l'âge, le sexe, la scolarité, la religion), cliniques (indice de masse corporelle, signes cliniques, antécédents familiaux, circonstance de découverte, complications du diabète, durée de la maladie) et thérapeutiques de 26 enfants diabétiques âgés de 8 à 20 ans et régulièrement suivis dans cette unité ont été analysées. Résultats. La population d'étude était constituée de 14 filles (53,8%) et de 12 garçons (46,2%). Les symptômes les plus fréquents observés étaient la polyurie (34,6%), l'amaigrissement et la polydipsie (38,5%). Les complications les plus fréquentes étaient, l'acidocétose (19,2%) lié à l'hyperglycémie chronique et l'hypoglycémie (57,7%) lié au traitement par insulinothérapie. En guise de traitement, 96,1% de ces patients étaient sous un schéma thérapeutique associant au quotidien une injection d'insuline d'action rapide (Actrapid) à deux injections d'insuline d'action intermédiaire (Insulatard ou Mixtard). Le taux moyen d'hémoglobine glyquée (9,27 ± 3,38%) traduisait un mauvais contrôle glycémique dans cette population. La proportion des patients contrôlés, c'est-à-dire, ceux qui avaient un taux d'hémoglobine glyquée inférieure ou égale à 7%, était plus faible chez les garçons (25%) comparés aux filles (42,9%). Conclusion. Nos données interpellent les différents acteurs impliqués dans la prise en charge du diabète de l'enfant, sur la nécessité d'amélioré la qualité de cette prise en charge
Objective. The study aimed at assessing the clinical and therapeutic aspects of diabetic children under follow-up at the Ngaoundere Regional Hospital. Methods. This was a descriptive retrospective cross-sectional study conducted from April 15 to July 10, 2021, at the Changing Diabetes In Children (CDIC) unit of the Ngaoundéré Regional Hospital. Sociodemographic data (age, sex, education, religion), clinical data (body mass index, clinical signs, family history, circumstance of discovery, complications of diabetes, duration of the disease), and therapeutic data of 26 diabetic children aged 8 to 20 and regularly followed in this unit were analyzed. Results. Our study population consisted of 14 girls (53.8%) and 12 boys (46.2%). The most common symptoms observed were polyuria (34.6%), weight loss, and polydipsia (38.5%). The most common complications were ketoacidosis (19.2%) related to chronic hyperglycemia and hypoglycemia (57.7%) related to insulin therapy. By way of treatment, 96.1% of these patients were on a therapeutic regimen combining a daily injection of fast-acting insulin (Actrapid) and two injections of intermediate-acting insulin (Insulatard or Mixtard). The average level of glycated hemoglobin (9.27 ± 3.38%) reflected poor glycemic control in this population. The proportion of controlled patients, that is to say, those who had a glycated hemoglobin level less than or equal to 7%, was lower in boys (25%) compared to girls (42.9%). Conclusion. Our data challenge the various actors involved in the management of childhood diabetes, on the need to improve the quality of this care.