Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 1.595
Filter
1.
Rev. bras. med. esporte ; 27(4): 410-413, Aug. 2021. tab
Article in English | LILACS | ID: biblio-1288603

ABSTRACT

ABSTRACT Introduction: According to the metabolic characteristics of ultra-long-distance swimming and the characteristics of energy utilization and absorption during exercise, we have formulated a nutritional supplement plan for crossing to study the influence of swimming sports on blood sugar and give biochemical feedback indicators. Objective: To lay a foundation for studying the nutrition supplement rules during long-term exercise by taking the athletes' blood after training to determine the changes in blood sugar, adjusting and determining the nutritional supplement plan during training. Methods: We monitor athletes' physical function changes and biochemical indicators during training and study the changes of these biochemical indicators and athletes' physical functions after long-term swimming exercises to scientifically arrange the exercise intensity and load during the training period. Results: The urine indexes after exercise did not change much, reflecting the exercise load's low intensity. The changes in blood lactic acid and blood urea indexes after exercise also confirmed this. During the training period, the athletes' hemoglobin and red blood cell parameters are in the ideal range, indicating that the athlete's physical function is in good condition. During the training period, the training load intensity and load are reasonable according to ultra-long-distance swimming's energy supply characteristics. After training, the changes in blood glucose indicators reflect that the nutritional supplement program we formulated for athletes is reasonable and feasible. Conclusions: By monitoring the blood sugar and biochemical indicators of swimmers, it can help athletes to arrange exercise intensity scientifically and load during the training period, to better carry out open water competitions in China, and to arrange training and scientific nutrition during the training period scientifically. Lay the foundation for the establishment of nutrition supplement theory and training theory for super long-time sports. Level of evidence II; Therapeutic studies - investigation of treatment results.


RESUMEN Introducción: De acuerdo con las características metabólicas de la natación de ultra larga distancia y las características de utilización y absorción de energía durante el ejercicio, hemos formulado un plan de complementos nutricionales para estudiar la influencia de los deportes de natación en el azúcar en sangre y dar indicadores de retroalimentación bioquímica. Objetivo: Sentar las bases para el estudio de las reglas de los suplementos nutricionales durante el ejercicio a largo plazo mediante la extracción de sangre de los atletas después del entrenamiento para determinar los cambios en el azúcar en sangre, ajustando y determinando el plan de suplementos nutricionales durante el entrenamiento. Métodos: monitoreamos los cambios en la función física de los atletas y los indicadores bioquímicos durante el entrenamiento y estudiamos los cambios de estos indicadores bioquímicos y las funciones físicas de los atletas después de ejercicios de natación de larga distancia para organizar científicamente la intensidad y la carga del ejercicio durante el período de entrenamiento. Resultados: Los índices de orina después del ejercicio no cambiaron mucho, lo que refleja la baja intensidad de la carga de ejercicio. Los cambios en los índices de ácido láctico y urea en sangre después del ejercicio también lo confirmaron. Durante el período de entrenamiento, los parámetros de hemoglobina y glóbulos rojos de los atletas están en el rango ideal, lo que indica que la función física del atleta está en buenas condiciones. Durante el período de entrenamiento, la intensidad de la carga de entrenamiento y la carga son razonables de acuerdo con las características de suministro de energía de la natación de ultra larga distancia. Después del entrenamiento, los cambios en los indicadores de glucosa en sangre reflejan que el programa de suplementos nutricionales que formulamos para los atletas es razonable y factible. Conclusiones: monitorear los indicadores bioquímicos y de azúcar en sangre de los nadadores, puede ayudar a los atletas a organizar científicamente la intensidad del ejercicio y la carga durante el período de entrenamiento, a realizar mejor las competiciones en aguas abiertas en China y a organizar el entrenamiento y la nutrición científica durante el período de entrenamiento. Sentar las bases para el establecimiento de la teoría de los suplementos nutricionales y la teoría del entrenamiento para deportes de larga duración. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.


RESUMO Introdução: De acordo com as características metabólicas da natação de ultra longa distância e as características de utilização e absorção de energia durante o exercício, formulamos um plano de suplemento nutricional para estudar a influência dos esportes de natação no açúcar no sangue e fornecer indicadores de feedback bioquímico. Objetivo: Estabelecer as bases para o estudo das regras de suplementos nutricionais durante exercícios de longa duração, retirando sangue de atletas após o treinamento para determinar as mudanças na glicemia, ajustando e determinando o plano de suplementação nutricional durante o treinamento. Métodos: monitoramos as mudanças na função física e nos indicadores bioquímicos dos atletas durante o treinamento e estudamos as mudanças nesses indicadores bioquímicos e nas funções físicas dos atletas após exercícios de natação de longa distância para organizar cientificamente a intensidade e a carga do exercício durante o período de treinamento. Resultados: As taxas de urina após o exercício não mudaram muito, refletindo a baixa intensidade da carga de exercício. Alterações nos índices de uréia e ácido láctico no sangue após o exercício também confirmaram isso. Durante o período de treinamento, os parâmetros de hemoglobina e hemácias dos atletas estão na faixa ideal, indicando que a função física do atleta está em boas condições. Durante o período de treinamento, a intensidade da carga de treinamento e a carga são razoáveis de acordo com as características da fonte de alimentação da natação de ultra longa distância. Após o treinamento, as mudanças nos indicadores de glicose no sangue refletem que o programa de suplementos nutricionais que formulamos para atletas é razoável e viável. Conclusões: monitorar os indicadores bioquímicos e de açúcar no sangue de nadadores pode ajudar os atletas a organizar cientificamente a intensidade e carga do exercício durante o período de treinamento, conduzir melhor competições em águas abertas na China e organizar treinamento e nutrição científica durante o período de treinamento. Estabelecendo as bases para o estabelecimento da teoria dos suplementos nutricionais e da teoria do treinamento para esportes de longa duração. Nível de evidência II; Estudos terapêuticos: investigação dos resultados do tratamento.


Subject(s)
Humans , Male , Adult , Swimming , Blood Glucose/analysis , Biomarkers/analysis , Dietary Supplements/analysis , Athletes , Feedback, Physiological , Models, Theoretical
2.
Rev. bras. med. esporte ; 27(4): 430-433, Aug. 2021. tab
Article in English | LILACS | ID: biblio-1288602

ABSTRACT

ABSTRACT Introduction: The need for a lactic acid cycle eliminates lactic acid produced during exercise. This process requires energy consumption. D-ribose supplementation can increase muscle cell energy, accelerate the synthesis of PRPP in the heart and skeletal muscle, and eliminate the pentose phosphate pathway in the low limit of glucose-6-phosphate dehydrogenase activity; it doubles the speed of ATP recovery, so supplementing ribose can improve exercise capacity and accelerate the elimination of lactic acid to improve recovery ability. Objective: Supplementing D-ribose can increase muscle cell energy and accelerate the regeneration of ATP in the myocardium and skeletal muscle. This experiment intends to explore the effects of anaerobic and aerobic exercise and anaerobic exercise capacity and recovery ability after supplementing D-ribose granules by observing the changes in exercise tests before and after nutritional supplementation and recovery indicators after exercise. Methods: The thesis used a paired design to randomly divide 24 male amateur tennis players into two groups (12 in each group): physical training group (control group), physical training + nutrition D-ribose group (test group), and the D- The effect of ribose on the aerobic and anaerobic exercise capacity of amateur tennis players. Results: The observation indexes of the two groups before the test were not statistically significant (P>0.05); after the test for eight weeks, the aerobic capacity indexes of the test group were higher than those of the control group (P<0.05), and also higher than those before the test (P<0.05)); The recovery of 3minHR and 5minHR of the experimental group after exercise was significantly faster than that of the control group (P<0.05). Conclusions: Nutritional D-ribose supplementation can enhance the aerobic training effect of amateur tennis players, improve aerobic and anaerobic exercise capacity, and accelerate heart rate recovery after exercise. Level of evidence II; Therapeutic studies - investigation of treatment results.


RESUMO Introdução: A necessidade de um ciclo de ácido lático elimina o ácido lático produzido durante o exercício. Este processo requer consumo de energia. A suplementação com D-ribose pode aumentar a energia das células musculares, acelerar a síntese de PRPP no coração e no músculo esquelético e eliminar a via da pentose fosfato no limite inferior da atividade da glicose-6-fosfato desidrogenase; ele dobra a velocidade de recuperação de ATP, portanto, a suplementação de ribose pode melhorar a capacidade de exercício e acelerar a eliminação de ácido láctico para melhorar a capacidade de recuperação. Objetivo: A suplementação de D-ribose pode aumentar a energia das células musculares e acelerar a regeneração de ATP no miocárdio e músculo esquelético. Este experimento pretende explorar os efeitos do exercício anaeróbio e aeróbio e da capacidade de exercício anaeróbio e capacidade de recuperação após a suplementação de grânulos de D-ribose, observando as mudanças nos testes de exercício antes e após a suplementação nutricional e indicadores de recuperação após o exercício. Métodos: A tese utilizou um desenho pareado para dividir aleatoriamente 24 tenistas amadores do sexo masculino em dois grupos (12 em cada grupo): grupo de treinamento físico (grupo controle), grupo de treinamento físico + nutrição D-ribose (grupo de teste) e o grupo D - O efeito da ribose na capacidade de exercício aeróbio e anaeróbio de tenistas amadores. Resultados: Os índices de observação dos dois grupos antes do teste não foram estatisticamente significantes (P> 0,05); após o teste por oito semanas, os índices de capacidade aeróbia do grupo teste foram maiores do que os do grupo controle (P <0,05), e também maiores do que aqueles antes do teste (P <0,05); A recuperação de 3minHR e 5minHR do grupo experimental após o exercício foi significativamente mais rápida do que a do grupo controle (P <0,05). Conclusões: A suplementação nutricional de D-ribose pode aumentar o efeito do treinamento aeróbio de jogadores de tênis amadores, melhorar a capacidade de exercício aeróbio e anaeróbio e acelerar a recuperação da freqüência cardíaca após o exercício. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción: La actividad física regular ayuda a mejorar las habilidades cardiovasculares y cerebrovasculares. Cómo evaluar la tensión nerviosa de los vasos cardiovasculares y cerebrovasculares a través del deporte es un tema candente. Objetivo: El artículo analiza la influencia de la participación regular en deportes sobre la función cardiovascular de las personas y los indicadores relacionados con la sangre. Métodos: Seleccionamos a 30 adultos mayores sanos que participan regularmente en deportes, registramos sus cambios en el ECG, presión arterial, frecuencia cardíaca y otros indicadores relacionados con la función cardiovascular, y analizamos la función sanguínea de los ancianos. Detección del recuento de glóbulos rojos (RBC), volumen de glóbulos rojos (MCV) y hemoglobina (Hb), creatinina sérica (Cr), glucosa en sangre (BGS), triglicéridos (TG), colesterol (TC), lipoproteínas de baja densidad (LDL) y se mide la lipoproteína de alta densidad (HDL). Resultados: Los adultos mayores que persisten en el ejercicio durante mucho tiempo tienen mejores indicadores que los que no lo hacen. Conclusión: El ejercicio aeróbico adecuado puede reducir la rigidez de los vasos sanguíneos en los ancianos. El ejercicio puede ayudar a los ancianos a aumentar la variabilidad de la frecuencia cardíaca y mejorar los indicadores sanguíneos y la masa corporal de la función nerviosa autónoma del corazón. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.


Subject(s)
Humans , Male , Ribose/administration & dosage , Exercise/physiology , Tennis , Dietary Supplements , Athletes , Sports Nutritional Physiological Phenomena , Diet, Healthy , Heart Rate/physiology , Models, Biological
3.
Rev. bras. med. esporte ; 27(2): 142-146, Apr.-June 2021. tab, graf
Article in English | LILACS | ID: biblio-1280056

ABSTRACT

ABSTRACT Introduction: Currently there is a lack of clarity around the use of Fourier transform infrared (FT-IR) spectroscopy to analyze the effect of creatine (Cr) supplementation on the secondary structures of skeletal muscle tissue protein subjected to exercise. Objective: The objective of this study was to evaluate the spectral characteristics of the tibialis anterior muscle in rats subjected to exercise in a pool and to Cr supplementation. Methods: Experiment 1. First, an experiment was conducted to ensure that FT-IR would be able to detect change in the secondary structures of skeletal muscle tissue protein in the group of sedentary rats (SED) and in the group of rats that received creatine supplementation (CRE). Experiment 2. Next, the effect of physical exercise on the spectral characteristics of muscle tissue, especially when compared to the groups without exercise practice, was examined. Results: It was possible to verify that the peaks centered on 1658 cm-1 (amide I) and 1546 cm-1 (amide II) are characteristic spectra and indicated as markers of protein content. Conclusion: Thus, FT-IR spectroscopy proved to be able to monitor changes in secondary structures of skeletal muscle protein in both animals that received supplements and in those subjected to exercise and both cases reconciled. Furthermore, the FT-IR technique proved to be a viable method for the nondestructive evaluation of skeletal muscle protein structures. Level of evidence II, Investigation of treatment results.


RESUMEN Introducción: Actualmente, no hay claridad en lo que se refiere al uso de la técnica de espectroscopia de Infrarrojo con transformada de Fourier (FT-IR) para análisis del efecto de la suplementación de creatina (Cr) sobre las estructuras secundarias de la proteína del tejido muscular esquelético sometido a ejercicio. Objetivo: El objetivo de este estudio fue evaluar las características espectrales del músculo tibial anterior de ratones sometidos a ejercicio en piscina y a la suplementación con Cr. Métodos: Experimento 1. En primer lugar, fue realizada una experiencia para asegurar que la FT-IR sería capaz de detectar la variación en las estructuras secundarias de la proteína del tejido muscular esquelético en el grupo de ratones sedentarios (SED) y el grupo de ratones que sólo recibieron suplemento de creatina (CRE). Experimento 2. A continuación, fue examinado el efecto del ejercicio físico sobre las características espectrales del tejido muscular, especialmente cuando comparado con los grupos sin práctica de ejercicio. Resultados: Fue posible verificar que los picos centrados en 1658 cm−1 (amida I) y 1546 cm−1 (amida II) son espectros característicos e indicados como marcadores del tenor proteico. Conclusión: Siendo así, la técnica de espectroscopia de FT-IR mostró ser capaz de monitorizar las variaciones en las estructuras secundarias de la proteína del tejido muscular esquelético, tanto en animales que recibieron suplementos, como en los que fueron sometidos a ejercicio y ambos casos conciliados. Además, la técnica FT-IR probó ser un método viable para la evaluación no destructiva de las estructuras proteicas en el músculo esquelético. Nivel de evidencia II, Investigación de los resultados del tratamiento.


RESUMO Introdução: Atualmente, não há clareza no que diz respeito ao uso da técnica de espectroscopia de infravermelho com transformada de Fourier (FT-IR) para análise do efeito da suplementação de creatina (Cr) sobre as estruturas secundárias da proteína do tecido muscular esquelético submetido a exercício. Objetivo: O objetivo deste estudo foi avaliar as características espectrais do músculo tibial anterior de ratos submetidos a exercício em piscina e à suplementação com Cr. Métodos: Experimento 1. Em primeiro lugar, foi realizada uma experiência para assegurar que a FT-IR seria capaz de detectar a variação nas estruturas secundárias da proteína do tecido muscular esquelético no grupo de ratos sedentários (SED) e no grupo de ratos que só receberam suplemento de creatina (CRE). Experimento 2. Em seguida, foi examinado o efeito do exercício físico sobre as características espectrais do tecido muscular, especialmente quando comparado com os grupos sem prática de exercício. Resultados: Foi possível verificar que os picos centrados em 1658 cm−1(amida I) e 1546 cm−1(amida II) são espectros característicos e indicados como marcadores do teor proteico. Conclusão: Assim sendo, a técnica de espectroscopia de FT-IR mostrou ser capaz de monitorar as variações nas estruturas secundárias da proteína do tecido muscular esquelético tanto em animais que receberam suplementos, quanto nos que foram submetidos a exercício e ambos os casos conciliados. Além disso, a técnica FT-IR provou ser um método viável para a avaliação não destrutiva de estruturas proteicas no músculo esquelético. Nível de evidência II, Investigação dos resultados do tratamento.


Subject(s)
Animals , Male , Rats , Dietary Supplements , Creatinine/administration & dosage , Muscles , Muscles/drug effects , Muscles/chemistry , Physical Conditioning, Animal , Swimming , Rats, Wistar , Spectroscopy, Fourier Transform Infrared
4.
Rev. bras. med. esporte ; 27(2): 151-155, Apr.-June 2021. graf
Article in English | LILACS | ID: biblio-1280055

ABSTRACT

ABSTRACT Introduction: The quest for better sports performance or simply for esthetic ends has led individuals to seek ergogenic resources indiscriminately to attain their goals. It is believed that nutritional supplements promote better strength, power, focus and better reaction time. Nutritional supplements are used to delay fatigue and increase athletic performance. Also, the anorectics, drugs derived from amphetamines and commonly sought for weight loss, act on the central nervous system by releasing substances that transmit the sensation of not being hungry. Supplements that promise quick solutions to these goals may have compounds in their formulas that compromise health. Objectives: In this study, the potential of creatine and Jack 3D® to boost physical performance and delay muscle fatigue was evaluated in animals that were given the supplements. Methods: The animals underwent 10 weeks of swim training at 80% of the maximum load and received creatine and/or Jack 3D. The muscle contractions were recorded by an electrophysiograph for analysis of muscle fatigue. Results: It was observed that the SED+CR group had significantly different values compared to the SED group and NAT+CR group showed significant differences between groups for the SED, SED+JACK, JACK, NAT and NAT+JACK groups (p <0.05). For the two last parameters, the SED group showed a significant difference in relation to the SED+CR, NAT and NAT+CR groups (p <0.05). Conclusions: These results demonstrate a possible positive influence of physical exercise associated with the use of creatine, delaying muscle fatigue and making an increase in sports performance possible. Level of Evidence III; Development of diagnostic criteria in consecutive patients (with "gold" reference standard applied) .


RESUMEN Introducción: La búsqueda por el mejor desempeño deportivo o simplemente para fines estéticos ha inducido a los individuos a buscar indiscriminadamente recursos ergogénicos para alcanzar el éxito. Se cree que la ingestión de suplementos nutricionales puede proporcionar mayor resistencia, potencia, enfoque y mejor tiempo de reacción. Los suplementos nutricionales son empleados para retardar el surgimiento de la fatiga y aumentar el desempeño atlético. También comúnmente buscados para adelgazamiento están los anorexígenos, medicamentos a base de drogas anfetamínicas, que actúan sobre el sistema nervioso central liberando sustancias que transmiten la sensación de ausencia de hambre. Los suplementos que prometen soluciones rápidas para estos objetivos pueden presentar en sus fórmulas, compuestos que comprometen la salud. Objetivo: En este estudio fue evaluado el potencial de la creatina y del Jack3D® para el desempeño físico y la fatiga muscular de los animales que recibieron la suplementación. Métodos: Los animales fueron sometidos a 10 semanas de entrenamiento de natación a 80% de la carga máxima y recibieron creatina y/o Jack3D. Las contracciones musculares fueron registradas por un electrofisiógrafo para análisis de la fatiga muscular. Resultados: Se observó que el grupo SED+CR presentó valores significativamente diferentes en comparación con el grupo SED y el grupo NAT+CR presentó diferencias significativas con relación a los grupos SED, SED+JACK, NAT y NAT+JACK (p < 0,05). En los dos últimos parámetros, el grupo SED presentó diferencia significativa con relación a los grupos SED+CR, NAT y NAT+CR (p < 0,05). Conclusión: Esos resultados demuestran una posible influencia positiva del ejercicio físico asociado al uso de la creatina, retardando la fatiga muscular y posibilitando un aumento en el desempeño deportivo. Nivel de evidencia III; Desarrollo de criterios diagnósticos en pacientes consecutivos (con estándar de referencia "oro" aplicado) .


RESUMO Introdução: A busca pelo melhor rendimento esportivo ou simplesmente para fins estéticos tem induzido indivíduos a procurarem indiscriminadamente recursos ergogênicos para atingir o êxito. Acredita-se que a ingestão de suplementos nutricionais pode proporcionar maior resistência, potência, foco e melhor tempo de reação. Os suplementos nutricionais são empregados afim de retardar o surgimento da fadiga e aumentar o desempenho atlético. Também comumente procuradas para emagrecimento estão os anorexígenos, medicamentos à base de drogas anfetamínicas, que agem sobre o sistema nervoso central liberando substâncias que transmitem a sensação de ausência de fome. Suplementos que prometem soluções rápidas para estes objetivos podem conter em suas fórmulas compostos que comprometem a saúde. Objetivos: Neste estudo foi avaliado o potencial da creatina e do Jack 3D®para o desempenho físico e fadiga muscular dos animais que receberam a suplementação. Métodos: Os animais foram submetidos a 10 semanas de treinamento de natação a 80% da carga máxima e receberam creatina e/ou Jack 3D. As contrações musculares foram registradas por um eletrofisiógrafo para análise da fadiga muscular. Resultados: Observou-se que o grupo SED+CR apresentou valores significativamente diferentes em comparação com o Grupo SED e o Grupo NAT+CR apresentou diferenças significativas com relação aos grupos SED, SED+JACK, NAT e NAT+JACK (p < 0,05). Nos dois últimos parâmetros, o Grupo SED apresentou diferença significativa com relação aos grupos SED+CR, NAT e NAT+CR (p < 0,05). Conclusão: Esses resultados demonstram uma possível influência positiva do exercício físico associado ao uso da creatina, retardando a fadiga muscular e possibilitando um aumento no desempenho esportivo. Nível de Evidência III; Desenvolvimento de critérios diagnósticos em pacientes consecutivos (com padrão de referência "ouro" aplicado) .


Subject(s)
Animals , Male , Mice , Physical Conditioning, Animal , Swimming , Muscle Fatigue/drug effects , Dietary Supplements , Creatine/administration & dosage , Physical Functional Performance , Models, Animal
5.
Rev. bras. med. esporte ; 27(spe2): 39-41, Apr.-June 2021. tab
Article in English | LILACS | ID: biblio-1280088

ABSTRACT

ABSTRACT Grape proanthocyanidin is a good health product, without side effects and excellent biological activity, but research in the field of sports tonic is still relatively slow. Currently, the technology of preparation and extraction of grape proanthocyanidins is relatively mature. This fact laid the groundwork for sports tonic proanthocyanidin research. This study first described the biological structure of proanthocyanidin in grapes, and built the immune system of volleyball players before and after taking proanthocyanidin sports supplements. He then analyzed the factors that influence immunity. The results show that the primary index subsystem is consistent with the total system in each phase, but there are still few differences over time, which can be divided into four phases: development, recession, recovery and stability; at the level of scientific training it is reasonable. Male and female athletes take exercise supplements containing proanthocyanidin at each level of training. Regarding humoral immunity and cellular immunity, there was no adverse reaction. This study may offer some reference value for other athletes before and after taking proanthocyanidin as a sports supplement.


RESUMO A proantocianidina da uva é um produto bom para a saúde, sem efeitos colaterais e excelente atividade biológica, mas a pesquisa no campo do tônico esportivo ainda é relativamente lenta. Atualmente, a tecnologia de preparação e extração das proantocianidinas de uva está relativamente madura. Este fato lançou as bases para a investigação da proantocianidina desportiva tónica. Este estudo descreveu, em primeiro lugar, a estrutura biológica da proantocianidina das uvas, e construiu o sistema imunitário dos jogadores de voleibol antes e depois de tomar suplementos desportivos de proantocianidina. Em seguida analisou os fatores que influenciam a imunidade. Os resultados mostram que o subsistema de índice primário é coerente com o sistema total em cada fase, mas ainda há poucas diferenças no tempo, que podem ser divididas em quatro fases: desenvolvimento, recessão, recuperação e estabilidade; no plano de formação científico e razoável. Os atletas do sexo masculino e feminino tomam suplementos de exercício contendo proantocianidina em cada estágio de treinamento. Com respeito à imunidade humoral e à imunidade celular não houve reação adversa. Este estudo pode oferecer algum valor de referência para outros atletas antes e depois de tomar proantocianidina como suplemento desportivo.


RESUMEN La proantocianidina de la uva es un producto bueno para la salud, sin efectos colaterales y excelente actividad biológica, pero la investigación en el campo del tónico deportivo aun es relativamente lenta. Actualmente, la tecnología de preparación y extracción de las proantocianidinas de uva está relativamente madura. Este hecho lanzó las bases para la investigación de la proantocianidina deportiva tónica. Este estudio describió, en primer lugar, la estructura biológica de la proantocianidina de las uvas, y construyó el sistema inmunitario de los jugadores de voleibol antes y después de tomar suplementos deportivos de proantocianidina. Enseguida analizó los factores que influencian la inmunidad. Los resultados muestran que el subsistema de índice primario es coherente con el sistema total en cada fase, pero aun hay pocas diferencias en el tiempo, que pueden ser divididas en cuatro fases: desarrollo, recesión, recuperación y estabilidad; en el plano de la formación científica es razonable. Los atletas del sexo masculino y femenino toman suplementos de ejercicio conteniendo proantocianidina en cada nivel de entrenamiento. Con respecto a la inmunidad humoral y a la inmunidad celular no hubo reacción adversa. Este estudio puede ofrecer algún valor de referencia para otros atletas antes y después de tomar proantocianidina como suplemento deportivo.


Subject(s)
Humans , Male , Female , Young Adult , Dietary Supplements , Proanthocyanidins/administration & dosage , Athletic Performance/physiology , Volleyball/physiology , Immunity/drug effects
6.
Arq. bras. med. vet. zootec. (Online) ; 73(3): 684-692, May-June 2021. tab
Article in English | ID: biblio-1278367

ABSTRACT

This study aimed to assess the effects of yellow grease supplementation on the intake, digestibility, and nitrogen balance in sheep. Twenty Santa Inês lambs with a mean age of 95 ± 10 d and body weight of 19.29 ± 3.17kg were evaluated in a completely randomized design. The diets were supplemented with oil at concentrations of 0, 20, 40, 60, and 80 gkg-1 of dry matter (DM) of the concentrate. The diets were based on roughage and concentrate (50:50). The experimental period lasted 19 d and included 14 adaptation days and five collection days for the total supplied diet, orts, feces, and urine. Supplementation with yellow grease had no significant effect on the intake of DM, crude protein (CP), neutral detergent fiber (NDF), or non-fiber carbohydrates (NFC). However, the ether extract (EE) intake increased linearly with supplementation of yellow grease. Moreover, no effect was observed for DM, CP, NDF, and NFC digestibility and nitrogen balance. EE digestibility increased linearly with the yellow grease dietary supplementation. Thus, sheep dietary supplementation with yellow grease may be used at a level of up to 80 gkg-1 of DM of concentrate without impairing nutrient intake and digestibility.(AU)


Objetivou-se, com o estudo, avaliar os efeitos do óleo residual de fritura, em dietas para ovinos, sob o consumo, a digestibilidade e o balanço de nitrogênio. Foram utilizados 20 cordeiros Santa Inês, com idade de 95 ± 10 dias e peso corporal de 19,29 ± 3,17kg, em delineamento inteiramente ao acaso. As dietas continham óleo de fritura nas concentrações de 0; 20; 40; 60 e 80gkg-1 da matéria seca (MS) do concentrado. As dietas tinham relação volumoso:concentrado de 50:50. O período experimental foi de 19 dias, incluindo 14 dias em adaptação e cinco dias de coleta do fornecido, das sobras, das fezes e da urina. A suplementação com óleo de fritura não alterou o consumo de MS, proteína bruta (PB), matéria orgânica (MO), fibra em detergente neutro (FDN) e carboidratos não fibrosos (CNF). Entretanto, o consumo de extrato etéreo (EE) aumentou com a inclusão do óleo. Não foi observado efeito na digestibilidade da MS, da PB, da FDN, dos CNF e no balanço de nitrogênio. A digestibilidade do EE aumentou com a inclusão do óleo. Assim, a inclusão de óleo de fritura em dietas para ovinos pode ser utilizada em até 80gkg-1 da MS do concentrado, sem limitar ingestão e digestibilidade dos nutrientes.(AU)


Subject(s)
Animals , Plant Oils , Sheep/metabolism , Animal Feed/analysis , Waste Products/analysis , Dietary Supplements/analysis
7.
Rev. cuba. endocrinol ; 32(1): e273, 2021. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1289392

ABSTRACT

Introducción: La búsqueda de nuevos fármacos o de productos naturales que mejoren la calidad de la atención y los resultados en el tratamiento de la diabetes mellitus continúan. La Moringa oleifera tiene variados usos y es uno de los productos naturales que desde hace años se evalúa con este fin, por sus sustanciales propiedades curativas. Objetivo: Evaluar los efectos de la Moringa oleifera como un producto natural con posibilidades de ser usado en pacientes con diabetes mellitus. Método: Se utilizaron como buscadores de información científica a SciELO, PubMed, Google y a Google Académico. La estrategia de búsqueda incluyó los siguientes términos como palabras claves: Moringa oleifera, diabetes mellitus, propiedades antidiabéticas, reacciones adversas. Se evaluaron artículos de revisión, de investigación y páginas Web que, en general, tenían menos de 10 años de publicados, en idioma español, portugués e inglés, y que hicieran referencia específicamente al tema de estudio a través del título. Esto permitió evaluar 120 artículos, de los cuales 64 fueron referenciados. Conclusiones: La Moringa oleifera es una planta que constituye un producto natural con propiedades nutracéuticas y funcionales. Puede usarse como un coadyuvante en los tratamientos convencionales indicados para el tratamiento de la diabetes mellitus, lo cual dependería de los resultados de ensayos clínicos rigurosos, que permitan dilucidar si realmente es capaz de contribuir a lograr en el humano, un control glucémico eficaz, sin efectos secundarios importantes e incluso ayudar a mejorar algunas de las complicaciones y comorbilidades que habitualmente acompañan a la diabetes mellitus(AU)


Introduction: The search of new drugs or natural products that improve the quality of care and the results of diabetes mellitus treatment continue. Moringa oleifera has different uses and is one of the natural products that have been assessed through the years with that purpose, due to its considerable curative properties. Objective: Assess the effects of Moringa oleifera as a natural product with chances of being used in patients with diabetes mellitus. Methods: There were used as scientific information searchers ScieELO, PubMed, Google and Google Scholar. The search strategy included the following terms as keywords: Moringa oleifera, diabetes mellitus, anti-diabetic properties, adverse reactions. Review articles, research articles and web pages were assessed; in general terms, those had less than 10 years of being published, were in Spanish, Portuguese and English languages, and were making specific reference in the title to the studied subject. This allowed assessing 120 articles, of which 64 were quoted. Conclusions: Moringa oleifera is a plant that constitutes a natural product with nutraceutical and functional properties. It can be used as a contributory agent in conventional treatments indicated for diabetes mellitus, which will depend on the results of strict clinical trials that allow to clarify if it is actually capable of contributing to achieve an efficient glycemic control in humans, without relevant side effects, or even to help improving some of the complications and comorbidities that usually accompany diabetes mellitus(AU)


Subject(s)
Humans , Quality of Health Care , Dietary Supplements , Moringa oleifera/adverse effects , Diabetes Mellitus/etiology , Reference Drugs , Review Literature as Topic , Databases, Bibliographic
8.
Rev. cuba. endocrinol ; 32(1): e247, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1289390

ABSTRACT

Introducción: La Spirulina platensis es una cianobacteria planctónica filamentosa, que contiene un espectro natural de mezclas de pigmentos de caroteno, xantofila y ficocianina, con actividad antioxidante y la posibilidad de inducir un mejor control de la glucemia en las personas con diabetes mellitus. Objetivo: Describir los efectos del uso del producto logrado a partir de la bacteria Spirulina platensis en el paciente con diabetes mellitus. Método: Se utilizaron como buscadores de información científica a PubMed, SciELO, Google y Google Académico. Las palabras claves utilizadas fueron: espirulina, Spirulina platensis, Arthrospira platensis, diabetes mellitus y control metabólico. Se evaluaron artículos de revisión, de investigación y páginas web que, en general, tenían menos de 10 años de publicados en idioma español, portugués e inglés, cuyos títulos estaban relacionados con el tema de estudio. Se obtuvieron 70 referencias bibliográficas, de las cuales 49 se citaron en el presente artículo. Conclusiones: La espirulina tiene varios efectos benéficos que permiten su uso como coadyuvante en la prevención y tratamiento de la diabetes mellitus. Es un nutriente con bondades nutraceúticas y funcionales, con potente actividad antioxidante, que incide en un mejor control glucémico y puede ser útil en el manejo de las posibles complicaciones y comorbilidades que acompañan a la diabetes mellitus. Su uso conlleva la posibilidad de algunas reacciones adversas, sobre todo de tipo digestivas, aunque no son frecuentes si se emplean las dosis recomendadas; en general, es considerada un producto seguro(AU)


Introduction: Spirulina platensis is a plankton filamentous cyanobacteria that has a natural spectrum of carotene, xanthophyll and phycocyanin pigments´mix, with antioxidant activity and the possibility of inducing a better control of glycemia in patients with diabetes mellitus. Objective: Describe the effects of the use in patients with diabetes mellitus of a product made from Spirulina platensis bacteria. Method: There were used as scientific information searchers: PubMed, SciELO, Google and Google Scholar. The keywords used were: Spirulina, Spirulina platensis, Arthrospira platensis, diabetes mellitus and metabolic control. There were assessed review articles, research articles and web pages, that in general had less than 10 years of being published in Spanish, Portuguese or English language, and whose titles were related with the studied topic. 70 bibliographic references were collected, and 49 of them were quoted in this article. Conclusions: Spirulina has different beneficial effects that allow its use as coadjuvant agent in the prevention and treatment of diabetes mellitus. It is a nutrient with functional and nutraceutical mildness, with a powerful antioxidant activity which has incidence in a better glycemic control and can be useful in the management of possible complications and comorbidities that accompany diabetes mellitus. Its use entails the possible adverse reactions, mainly digestive ones; although they are not frequent if the recommended doses are used. In general terms, it is considered a safe product(AU)


Subject(s)
Humans , Biological Products/therapeutic use , Dietary Supplements/adverse effects , Diabetes Mellitus/epidemiology , Spirulina , Review Literature as Topic , Databases, Bibliographic
9.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 214-222, Jan.-Feb. 2021. tab
Article in Portuguese | ID: biblio-1153052

ABSTRACT

Objetivou-se avaliar a influência da suplementação com minerais biocomplexados sobre a qualidade da carne de frangos da linhagem Label Rouge, de ambos os sexos, criados em sistema alternativo. O delineamento experimental foi inteiramente ao acaso (DIC), disposto em esquema fatorial (3x2), sendo três dietas (controle; 0,50ppm de selênio; 0,40ppm de cromo) e dois sexos. Para a estabilidade lipídica, foi utilizado o DIC, disposto em esquema fatorial (3x2x2), sendo três dietas, dois sexos e dois tempos de armazenamento (zero e 12 meses). Os parâmetros avaliados no peito e na coxa foram: pH final, cor (L* - luminosidade, a* - índice de vermelho, b* - índice de amarelo, C* - índice de saturação e h* - ângulo de tonalidade), perda de peso por cozimento (PPC), força de cisalhamento (FC) e estabilidade lipídica. Além disso, foram avaliadas a proporção das formas químicas da mioglobina da coxa e a quantificação do conteúdo de selênio no peito. Não houve efeito isolado da dieta sobre os parâmetros físicos e químicos do peito e da coxa e sobre a concentração de selênio no peito. As fêmeas apresentaram médias superiores de L* (57,57), b* (10,55) e C* (10,60) do peito; e os machos de L* (55,09) da coxa. Entre os machos, as aves alimentadas com a dieta controle e com cromo expressaram valores superiores de FC da coxa em relação às suplementadas com selênio; para o tratamento com cromo, os machos apresentaram média superior de FC da coxa e, em contrapartida, para o tratamento com selênio, as fêmeas manifestaram a maior média. As amostras submetidas ao período de 12 meses de armazenamento mostraram maiores valores de substâncias reativas ao ácido tiobarbitúrico (TBARS) em ambos os cortes. A suplementação com cromo e selênio biocomplexados não provocou alterações na qualidade da carne; as fêmeas demonstraram melhores atributos de qualidade da carne.(AU)


The objective of the present study was to evaluate the influence of the supplementation with biocomplexed minerals on the quality of the meat of label Rouge lineage chicken, of both genders, reared in an alternative system. The experimental design was completely randomized (CRD) in a factorial scheme (3x2), with three diets (control; 0.50ppm of selenium; 0.40ppm of chromium) and two genders. For lipid stability, the CRD arranged in a factorial scheme (3x2x2) was used, being three diets, two genders and two storage times (0 and 12 months). The parameters evaluated in the breast and in the thigh were: final pH, color (L* - luminosity, a* - red index, b* - yellow index, C* - saturation index and h* - tonality angle), weight loss per cooking (WLC), shear force (SF) and lipid stability. In addition, we evaluated the proportion of chemical forms of myoglobin of the thigh and the quantification of selenium content in the breast. There was no isolated effect of diet on the physical and chemical parameters of the breast and thigh and selenium concentration in the breast. Females had higher mean values of L* (57.57), b* (10.55) and C* (10.60) of the breast; and males of L* (55.09) of the thigh. Among males, poultry fed with the control diet and chromium showed higher SF values of the thigh than those supplemented with selenium; for the treatment with chromium, the males presented superior average of SF of the thigh and, in contrast, for the treatment with selenium, the females had the highest average. Samples submitted to the period of 12-month of storage showed higher values of substances reactive to thiobarbituric acid (TBARS) in both cuts. Supplementation with biocomplexed chromium and selenium did not cause changes in meat quality; females presented better attributes of meat quality.(AU)


Subject(s)
Animals , Selenium/administration & dosage , Chickens/growth & development , Chromium/administration & dosage , Meat/analysis , Myoglobin , Dietary Supplements/analysis , Animal Feed/analysis
10.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 82-90, Jan.-Feb. 2021. tab, graf
Article in English | ID: biblio-1153042

ABSTRACT

Essential oils (EO) such as carvacrol represent a wide range of mainly volatile aromatic plant compounds which hold antioxidant, antibacterial and antifungal potential, in addition to other properties of interest to animal health, such as the ability to modulate the microbiome. Current horse care commonly involves an intensive management system with an excessive use of concentrated feed, which can lead to severe digestive and metabolic disorders. Studies with EO in horses are limited, but the use of carvacrol essential oil (CEO) can promote benefits in microbial fermentation. The objective was to investigate the effect of different quantities of CEO on the apparent total digestibility of nutrients, microbial profile in the feces and postprandial blood glucose and insulin response when added to the equine diet. Eight Mini-Horse geldings were used (42±6 months; 135±15 kg BW) and fed with a proportion of 60% concentrate and 40% grass hay. The treatments were: 0, 100, 200 and 300 ppm of CEO. The addition of CEO up to 300 ppm did not influence the apparent digestibility of nutrients or the postprandial plasma glucose and insulin response. The use of CEO maintained the fermentative digestive health of horses fed with concentrate diets.(AU)


Os óleos essenciais (EO), como o carvacrol, são descritos por representarem ampla gama de compostos principalmente voláteis de plantas aromáticas, com potencial antioxidante, antibacteriano, antifúngico, entre outras propriedades de interesse para a saúde animal, como a modulação do microbioma. Atualmente, os cavalos são submetidos a manejo intensivo, com uso excessivo de ração concentrada, o que pode causar graves distúrbios digestivos e metabólicos. Em cavalos, estudos com EO são limitados, mas o uso de óleo essencial de carvacrol (CEO) poderia promover benefícios na fermentação microbiana. O objetivo da presente pesquisa foi investigar o efeito de diferentes quantidades de óleo essencial de carvacrol, adicionadas à dieta de equinos, sobre a digestibilidade aparente total de nutrientes, o perfil microbiano por meio das fezes e a resposta sanguínea pós-prandial de glicose e insulina. Foram utilizados oito cavalos castrados, da raça Mini-Horse (42±6 meses), 135±15kg PV, alimentados na proporção de 60% concentrado e 40% feno de capim. Os tratamentos foram: 0, 100, 200 e 300ppm de CEO. A adição de CEO até 300ppm não influencia a digestibilidade aparente dos nutrientes e a resposta de glicose e insulina plasmática pós-prandial. O uso de EO demonstra manter a saúde digestiva fermentativa quando os cavalos são alimentados com dieta rica em concentrado.(AU)


Subject(s)
Animals , Oils, Volatile/therapeutic use , Digestion/drug effects , Glucose , Horses/blood , Insulin/blood , Dietary Supplements/analysis , Monoterpenes
11.
Univ. salud ; 23(1): 46-54, ene.-abr. 2021. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1157008

ABSTRACT

Resumen Introducción: La obesidad sarcopénica no está claramente definida, pero se entiende como la relación sinérgica entre la pérdida de masa y función muscular, con aumento de masa grasa, propio de la obesidad que se acentúa con la edad. Objetivo: Analizar los efectos del ejercicio físico y suplementación nutricional sobre la obesidad sarcopénica en adultos mayores. Materiales y métodos: Se realizó una búsqueda bibliográfica de artículos publicados entre el 2015 y 2020 en las bases de datos Medline a través de Pubmed, SciELO y Google Scholar utilizando los términos Sarcopenia, Obesity, Frail Elderly, Exercise y Dietary supplements. Los artículos analizados consideraron solo revisiones narrativas o sistemáticas, con o sin metanálisis el efecto de una intervención de ejercicio y/o suplementación nutricional en adultos mayores. Resultados: Se presentan los criterios de definición y relación entre obesidad y sarcopenia abordados desde intervenciones de ejercicios físicos y nutricionales para la prevención y/o tratamiento de obesidad sarcopénica. Conclusiones: Las diferentes estrategias de ejercicio físico y suplementación nutricional, tanto separadas como combinadas, pueden prevenir y/o contrarrestar la obesidad sarcopénica en adultos mayores, puesto que impactan parámetros fundamentales como la composición corporal y el rendimiento físico asociado a la calidad de vida.


Abstract Introduction: Although sarcopenic obesity is not clearly defined, it is understood as the synergistic relationship between the loss of muscle mass and function with an increase in fat mass, which characterizes the obesity that increases with age. Objective: To analyze the effects of physical exercise and nutritional supplementation on sarcopenic obesity in older adults. Materials and methods: A bibliographic search of reports published between 2015 and 2020 in the Medline database through Pubmed, SciELO and Google Scholar was conducted, using the terms Sarcopenia, Obesity, Frail Elderly Exercise and Dietary Supplements. The search included narrative and systematic reviews, with or without meta-analyses of the effect of interventions through exercise and/or nutritional supplementation in older adults. Results: The definition criteria and relationship between obesity and sarcopenia were addressed using interventions with physical and nutritional exercises to prevent and/or treat sarcopenic obesity. Conclusions: The different strategies of physical exercise and nutritional supplementation, either individually or in combination, can prevent and/or counteract sarcopenic obesity in older adults, since they affect fundamental parameters such as body composition and the physical performance associated with quality of life.


Subject(s)
Frail Elderly , Obesity , Exercise , Dietary Supplements , Sarcopenia
12.
Article in English | AIM | ID: biblio-1292744

ABSTRACT

Introduction : L'épidémie de Covid-19 a créé une psychose et une anxiété généralisées. Cela pourrait être lié, d'une part, à la mortalité élevée observée dans le monde, et d'autre part, à l'absence d'une thérapie spécifique. Face à cette situation, de nombreuses substances ont été utilisées sans avis médical. L'objectif de cette étude était d'évaluer les pratiques de l'automédication en situation de Covid-19 à Oran. Matériel et méthodes : Il s'agit d'une enquête transversale observationnelle réalisée par questionnaire électronique anonyme (googleforms) et distribué, par e-mail, à des pharmaciens adhérents à la section ordinale régionale des pharmaciens d'Oran. Les réponses ont été analysées par le logiciel Statistical Package for the Social Sciences (SPSS). Résultats : Au total, 69 réponses ont été obtenues. La proportion de pharmaciens ayant perçu une tendance à la hausse de l'automédication était de 58,0%. Environ le quart des pharmaciens (22,9%) avaient constaté une augmentation de l'automédication à l'hydroxychloroquine ; néanmoins, aucune toxicité secondaire à l'usage de ce médicament n'a été observée. En cette situation d'épidémie de Covid-19, 91.3% de l'échantillon d'étude avaient constaté une augmentation du recours aux vitamines et compléments alimentaires, avec une consommation fréquente de la vitamine C à 1gr/j ainsi que d'autres complexes vitaminiques à base de vitamine D, vitamine B9 et fer chez la femme enceinte ou allaitante. Conclusion : Notre étude a montré qu'en période de Covid - 19 la tendance à l'automédication a augmenté. L'automédication à l'hydroxychloroquine a été observée durant cette pandémie néanmoins l'usage d'autres substances telles que les vitamines et les compléments alimentaires était plus fréquent.


Introduction : the epidemic of Covid-19 has created generalized psychosis and anxiety. This could be linked, on the one hand to the high mortality observed in the word, and the other hand to the absence of specific therapy. Faced with this situation, many substances have been used without medical advice. The objective of this study was to evaluate the practice of self-medication in COVID-19 situation in Oran. Materials and methods : this is an observational cross sectional survey carried out by an anonymous electronic questionnaire and distributed, by email, to pharmacist belonging to the regional ordinal section of pharmacist in Oran. The answers were analysed by the software Statistical Package for the Social Sciences (SPSS). Results : A total of 69 responses were obtained. The proportion of pharmacists who noticed an increasing trend in self-medication was 58,0%. About a quarter of pharmacist had observed an increase in selfmedication with hydroxychloroquin, at least no toxicity secondary to the use of this drug was observed. In this COVID19 epidemic situation, 91.3% of the study sample noted an increase in the use of vitamins and food supplements with frequent consumption of vitamin C at 1g/day as well as other vitamin comlexes based on vitamin D, vitamin B9 and iron for pregnant or breastfeeding women. Conclusion : Our study showed that during COVID-19 the tendency to self-medication increased. Self-medication with hydroxychloroquin was observed during this pandemic, although the use of other substances such as vitamins and food supplements was more frequent.


Subject(s)
Humans , Self Medication , Dietary Supplements , COVID-19 , Hydroxychloroquine , Vitamins , Algeria
13.
Article in Chinese | WPRIM | ID: wpr-879123

ABSTRACT

This paper introduced the basic definition, application scope, advantages and challenges of the master protocol, basket design, umbrella design and platform trial, and put forward the idea of using master protocol, basket design and umbrella design in Chinese medicine(CM) by considering the characteristics of CM and research experiences. The author pointed out that master protocol, basket design and umbrella design, as a high-efficiency research and design strategy, can be used in the clinical research on the treatment of the same disease with different therapies, the treatment of different diseases with the same therapy and the combination of diseases and CM syndromes. In particular, the exploration from the classification of CM syndromes can supplement the gaps in the cli-nical research on CM syndromes. In the application of such designs, it is also necessary to pay attention to their potential challenges and develop reasonable and feasible plans on research implementation, management and statistical analysis in advance to meet these challenges.


Subject(s)
Dietary Supplements , Medicine, Chinese Traditional , Precision Medicine , Records , Research Design
14.
Article in Chinese | WPRIM | ID: wpr-878728

ABSTRACT

Gestational diabetes mellitus(GDM)can cause blood glucose disorders in pregnant women and result in adverse maternal-neonatal outcomes.Vitamin D(VD)can improve glucose tolerance and insulin sensitivity,and thus theoretically,VD supplementation during pregnancy could improve glycemic control as well as maternal-neonatal outcomes in GDM patients.Although studies have shown that VD deficiency is associated with poor maternal-neonatal outcomes in GDM patients,no solid conclusion has been drawn with regard to the effects of VD supplementation on these patients.Therefore,here we summarized the research progress of the effects of VD supplementation on glycemic control and adverse maternal-neonatal outcomes in GDM patients,in an effort to guide the clinical VD supplementation during pregnancy.


Subject(s)
Blood Glucose , Diabetes, Gestational/drug therapy , Dietary Supplements , Female , Glycemic Control , Humans , Infant, Newborn , Pregnancy , Pregnancy Outcome , Vitamin D
15.
Article in Chinese | WPRIM | ID: wpr-878703

ABSTRACT

Objective To evaluate the effects of vitamin D supplementation on serum lipid profiles and neonatal prognosis in gestational diabetes mellitus(GDM)patients.Methods The electronic databases including PubMed,Web of Science,Embase,CNKI,and Wanfang Data were searched from inception to February 1,2020.All randomized controlled trials that compared vitamin D supplementation with placebo or without supplementation for GDM women were included.Paper selection,data extraction,meta-analysis and sensitivity analysis were conducted independently by two authors.Risk of bias was assessed using the Cochrane Risk of Bias Tool.The data were analyzed in RevMan 5.3 software and Stata 12.0.Results Totally 17 randomized controlled trials involving 1432 patients(704 in the intervention group and 728 in the control group)were included in the meta-analysis.The results showed that vitamin D supplementation significantly reduced serum total cholesterol [MD=-6.11,95% CI=(-7.17,-5.04)],low-density lipoprotein cholesterol [MD=-10.80,95% CI=(-14.72,-6.89)],and triglyceride [MD=-8.11,95% CI=(-10.09,-6.13)],while significantly increased serum 25-hydroxyvitamin D3 level [MD=45.45,95% CI=(41.98,48.92)] and high-density lipoprotein cholesterol [MD=2.77,95% CI=(1.59,3.96)].In addition,vitamin D supplementation significantly reduced the incidence rate of hyperbilirubinemia [RR=0.49,95% CI=(0.35,0.68)],premature birth [RR=0.44,95% CI=(0.27,0.72)],and neonatal hospitalization [RR=0.44,95% CI=(0.29,0.67)].Conclusions Vitamin D supplementation may regulate the serum lipid profiles in patients with GDM and reduce the incidence of adverse neonatal outcomes.More high-quality RCTs are needed to confirm the findings in our study.


Subject(s)
Diabetes, Gestational/drug therapy , Dietary Supplements , Female , Humans , Infant, Newborn , Pregnancy , Premature Birth , Randomized Controlled Trials as Topic , Vitamin D , Vitamins
16.
Article in English | WPRIM | ID: wpr-878371

ABSTRACT

Objective@#This study aimed to investigate the effects of @*Methods@#In this study, 0.1% DMG was supplemented in 20% casein diets that were either folate-sufficient (20C) or folate-deficient (20CFD). Blood and liver of rats were subjected to assays of Hcy and its metabolites. Hcy and its related metabolite concentrations were determined using a liquid chromatographic system.@*Results@#Folate deprivation significantly increased pHcy concentration in rats fed 20C diet (from 14.19 ± 0.39 μmol/L to 28.49 ± 0.50 μmol/L; @*Conclusion@#DMG supplementation exhibited hypohomocysteinemic effects under folate-sufficient conditions. By contrast, the combination of folate deficiency and DMG supplementation has deleterious effect on pHcy concentration.


Subject(s)
Animals , Biomarkers/metabolism , Chromatography, Liquid , Diet , Dietary Supplements , Folic Acid Deficiency/metabolism , Homocysteine/metabolism , Liver/metabolism , Male , Random Allocation , Rats , Rats, Wistar , Sarcosine/metabolism
17.
J. appl. oral sci ; 29: e20210483, 2021. graf
Article in English | LILACS | ID: biblio-1154617

ABSTRACT

Abstract Objective The aim of this study was to evaluate whether probiotics multi-strain formula affects the development of apical periodontitis (AP) induced in rats. Methodology 16 Wistar rats were divided in two groups (n=8): rats with AP fed with regular diet (Control-C (CG)); rats with AP, fed with regular diet and supplemented with multi-strain formula (one billion colony-forming units (CFU)): GNC Probiotic Complex (PCG) ( Lactobacillus acidophilus, Lactobacillus salivaris, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium animalis subs. lactis and Streptococcus thermofilus ). AP was induced in the upper and lower first molars by dental pulp exposure to the oral environment. PCG was administered orally through gavage for 30 days during the AP development. After this period the animals were euthanized and the mandibles were removed and processed for histologic analysis, and immunochemical assays for interleukin (IL)-6, IL-10, IL-1β, RANKL, OPG, and TRAP. The Mann-Whitney U test and Student's t test were performed (P<.05). Results The CG showed more intense inflammatory infiltrate than the PCG group (P<.05). IL-1β, IL 6 and RANKL decreased in the PCG group compared with CG (P<.05). The IL-10 level increased in the PCG group (P<.05). The OPG level was similar in both groups (P>.05). The number of mature osteoclasts (TRAP-positive multinucleated cells) was lower in PCG group when compared to the CG (P<.05). Conclusion Probiotic Complex modulates inflammation and bone resorption in apical periodontitis.


Subject(s)
Animals , Rats , Periapical Periodontitis/therapy , Probiotics , Lactobacillus rhamnosus , Rats, Wistar , Dietary Supplements
18.
Braz. j. med. biol. res ; 54(6): e10577, 2021. tab, graf
Article in English | LILACS | ID: biblio-1285665

ABSTRACT

Endothelial dysfunction is a well-known component of the pathophysiology of heart failure (HF), with proven prognostic value. Dietary supplementation with whey protein (WP) has been widely used to increase skeletal muscle mass, but it also has vascular effects, which are less understood. This study aimed to evaluate the effects of WP supplementation on the systemic microvascular function of HF patients. This was a blinded, randomized, placebo-controlled clinical trial that evaluated the effects of 12-week WP dietary supplementation on systemic microvascular function, in patients with HF New York Heart Association (NYHA) classes I/II. Cutaneous microvascular flow and reactivity were assessed using laser speckle contrast imaging, coupled with pharmacological local vasodilator stimuli. Fifteen patients (aged 64.5±6.2 years, 11 males) received WP supplementation and ten patients (aged 68.2±8.8 years, 8 males) received placebo (maltodextrin). The increase in endothelial-dependent microvascular vasodilation, induced by skin iontophoresis of acetylcholine, was improved after WP (P=0.03) but not placebo (P=0.37) supplementation. Moreover, endothelial-independent microvascular vasodilation induced by skin iontophoresis of sodium nitroprusside, was also enhanced after WP (P=0.04) but not placebo (P=0.42) supplementation. The results suggested that dietary supplementation with WP improved systemic microvascular function in patients with HF.


Subject(s)
Humans , Male , Middle Aged , Aged , Vasodilation , Heart Failure/drug therapy , Skin , Vasodilator Agents/pharmacology , Endothelium, Vascular , Pilot Projects , Dietary Supplements , Whey Proteins/pharmacology , Microcirculation
19.
Clinics ; 76: e1821, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153986

ABSTRACT

OBJECTIVES: This study aimed to evaluate the potential anti-inflammatory effects of vitamin D supplementation under uremic conditions, both in vivo and in vitro, and its effects on the parameters of mineral metabolism. METHODS: Thirty-two hemodialysis patients were randomly assigned to receive placebo (N=14) or cholecalciferol (N=18) for six months. Serum levels of calcium, phosphate, total alkaline phosphatase, intact parathyroid hormone (iPTH), and vitamin D were measured at baseline and after three and six months. The levels of fibroblast growth factor-23 (FGF-23), interleukin-1β (IL-1β), and high-sensitivity C-reactive protein (hs-CRP) were also measured at baseline and at six months. Human monocytes were used for in vitro experiments and treated with cholecalciferol (150 nM) and uremic serum. Cell viability, reactive oxygen species (ROS) production, and cathelicidin (CAMP) expression were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, dichloro-dihydro-fluorescein diacetate assay, and real time-quantitative polymerase chain reaction, respectively. RESULTS: Both patient groups were clinically and biochemically similar at baseline. After six months, the levels of vitamin D and iPTH were higher and lower, respectively, in the cholecalciferol group than in the placebo group (p<0.05). There was no significant difference between the parameters of mineral metabolism, such as IL-1β and hs-CRP levels, in both groups. Treatment with uremic serum lowered the monocyte viability (p<0.0001) and increased ROS production (p<0.01) and CAMP expression (p<0.05); these effects were counterbalanced by cholecalciferol treatment (p<0.05). CONCLUSIONS: Thus, cholecalciferol supplementation is an efficient strategy to ameliorate hypovitaminosis D in hemodialysis patients, but its beneficial effects on the control of secondary hyperparathyroidism are relatively unclear. Even though cholecalciferol exhibited anti-inflammatory effects in vitro, its short-term supplementation was not effective in improving the inflammatory profile of patients on hemodialysis, as indicated by the IL-1β and hs-CRP levels.


Subject(s)
Humans , Vitamin D Deficiency , Cholecalciferol/therapeutic use , Parathyroid Hormone/therapeutic use , Vitamin D , Renal Dialysis , Dietary Supplements , Anti-Inflammatory Agents
20.
Rev. saúde pública (Online) ; 55: 26, 2021. tab, graf
Article in English | LILACS, BBO | ID: biblio-1252104

ABSTRACT

ABSTRACT OBJECTIVE: To assess total usual nutrient intakes from foods and dietary supplements by age, sex, physical activity, and nutritional status, and to compare usual nutrient intakes to the Dietary Reference Intakes among non-users and users of dietary supplements in an urban population. METHODS: Cross-sectional population-based survey with 506 adults conducted in the city of Brasília, Brazil, using 24h food recalls. The 24-HR was collected on two nonconsecutive days, for which individuals reported all food, supplements, and beverages consumed in the previous 24 hours. The estimates of mean and the distribution percentiles were adjusted to reflect usual nutrient intake using the Iowa State University method. The prevalence of inadequate micronutrient intake was estimated according to sex using the Estimated Average Requirement (EAR), and values above the Tolerable Upper Intake Level (UL) were also considered. Also, a comparison was made of the total mean usual intake between supplement users and non-users according to BMI and physical activity. RESULTS: The total mean usual dietary intake was significantly higher among users than non-users of dietary supplements (p ≤ 0.02). Dietary supplement use increased intakes of nutrients and decreased prevalence of inadequacy according to sex, with only small (typically < 13%) increases in the population exceeding the Tolerable Upper Intake Level. There was a significant interaction between physical activity and BMI categories with supplement use. CONCLUSIONS: The population that consumes food supplements comprises individuals with more advanced age, female, normal BMI, and physically active. Our findings show that the use of supplements appears beneficial to attain nutrient adequacy. Careful monitoring of intake from food and supplements is recommended, and the statistical methods must be powerful enough to achieve relevant information.


Subject(s)
Humans , Female , Adult , Dietary Supplements , Diet , Urban Population , Brazil , Nutrition Surveys , Cross-Sectional Studies , Nutritional Requirements
SELECTION OF CITATIONS
SEARCH DETAIL