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1.
Article in English | WPRIM | ID: wpr-880675

ABSTRACT

Magnetic resonance imaging (MRI) is a very important imaging method for diagnosis and treatment of prostate cancer (PCa) in clinical practice. As functional MRI is growing and maturing, its quantitative parameters are expected to enhance the clinical value of MRI furtherly. Intravoxel incoherent motion diffusion imaging, diffusion tensor imaging, and diffusion kurtosis imaging, which were derived from diffusion weighted imaging, have provided richer and more accurate parameters. The newly-developed magnetic resonance elastography can complement the mechanical characteristics of PCa.


Subject(s)
Diffusion Magnetic Resonance Imaging , Diffusion Tensor Imaging , Humans , Magnetic Resonance Imaging , Male , Motion , Prostatic Neoplasms/diagnostic imaging
2.
Article in Chinese | WPRIM | ID: wpr-879282

ABSTRACT

Diffusion tensor imaging technology can provide information on the white matter of the brain, which can be used to explore changes in brain tissue structure, but it lacks the specific description of the microstructure information of brain tissue. The neurite orientation dispersion and density imaging make up for its shortcomings. But in order to accurately estimate the brain microstructure, a large number of diffusion gradients are needed, and the calculation is complex and time-consuming through maximum likelihood fitting. Therefore, this paper proposes a kind of microstructure parameters estimation method based on the proximal gradient network, which further avoids the classic fitting paradigm. The method can accurately estimate the parameters while reducing the number of diffusion gradients, and achieve the purpose of imaging quality better than the neurite orientation dispersion and density imaging model and accelerated microstructure imaging via convex optimization model.


Subject(s)
Brain/diagnostic imaging , Diffusion Magnetic Resonance Imaging , Diffusion Tensor Imaging , Neurites , White Matter
3.
Frontiers of Medicine ; (4): 125-138, 2021.
Article in English | WPRIM | ID: wpr-880937

ABSTRACT

This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson's disease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-related heterogeneity. Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls (HC) using the anisotropic effect size-signed differential mapping. A total of 808 patients with PD and 760 HC coming from 27 databases were finally included. Subgroup analyses were conducted considering heterogeneity with respect to medication status, disease stage, analysis methods, and the number of diffusion directions in acquisition. Compared with HC, patients with PD had decreased FA in the left middle cerebellar peduncle, corpus callosum (CC), left inferior fronto-occipital fasciculus, and right inferior longitudinal fasciculus. Most of the main results remained unchanged in subgroup meta-analyses of medicated patients, early stage patients, voxel-based analysis, and acquisition with 30 diffusion directions. The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex. The cerebellum and CC, associated with typical motor impairment, showed the most consistent FA decreases in PD. Medication status, analysis approaches, and the number of diffusion directions have an important impact on the findings, needing careful evaluation in future meta-analyses.


Subject(s)
Anisotropy , Brain/diagnostic imaging , Corpus Callosum , Diffusion Tensor Imaging , Humans , Parkinson Disease/diagnostic imaging , White Matter/diagnostic imaging
4.
Acta Physiologica Sinica ; (6): 407-422, 2021.
Article in Chinese | WPRIM | ID: wpr-887677

ABSTRACT

As the two essential components, the white matter and gray matter compose the central nervous system of the brain. Widely known that axons of neurons mainly form the white matter, and these formed nerve fibers are responsible for transmitting information among various brain regions to achieve the coordinated operation of the entire brain. Early research on the white matter could only be done by dissecting living animals or human cadavers, until Basser et al. proposed diffusion tensor imaging (DTI) technology in 1994, which could detect the diffusion characteristics of water in the brain in vivo noninvasively. Accordingly, this technology could be applied to investigate the diffusion movement of water in white matter to obtain the information of direction and micro-anatomy of white matter fiber bundles. With the advancement on the display and analysis of the anatomical structure of white matter fiber bundles, the exploration of microscopic pathological changes, and the assistance of clinical diagnosis and neurophysiological research, DTI technology has become one of the most popular topics in brain science research. Chronic pain refers to pain lasting more than three months, which not only seriously affects the patient's physical and social functions, but also dramatically reduces the quality of life. It was reported that long-term pain stimulation might cause pathological remodeling of the central nervous system, and abnormalities in white matter were found in imaging examinations of patients with chronic pain. This review introduces the quantitative analysis methods of white matter fiber bundle microstructure based on DTI and its application in chronic pain, and further discusses the application value of DTI technology on clinical research of chronic pain.


Subject(s)
Animals , Brain , Chronic Pain/diagnostic imaging , Diffusion Tensor Imaging , Humans , Quality of Life , White Matter/diagnostic imaging
5.
Article in English | WPRIM | ID: wpr-810980

ABSTRACT

OBJECTIVE: We aimed to investigate the ability of readout-segmented echo-planar imaging (rs-EPI)-based diffusion tensor imaging (DTI) in assessing the microstructural change of extraocular muscles (EOMs) and optic nerves in patients with thyroid-associated orbitopathy (TAO) as well as in evaluating disease activity.MATERIALS AND METHODS: We enrolled 35 TAO patients and 22 healthy controls (HCs) who underwent pre-treatment rs-EPI-based DTI. Mean, axial, and radial diffusivity (MD, AD, and RD) and fractional anisotropy (FA) of the medial and lateral EOMs and optic nerve for each orbit were calculated and compared between TAO and HC groups and between active and inactive TAO groups. Factors such as age, sex, disease duration, mediation, and smoking history between groups were also compared. Logistic regression analysis was used to evaluate the predictive value of significant variables for disease activity.RESULTS: Disease duration was significantly shorter in active TAOs than in inactive ones (p < 0.001). TAO patients showed significantly lower FA and higher MD, AD, and RD than HCs for both medial and lateral EOMs (p < 0.001), but not the AD value of lateral EOMs (p = 0.619). Active patients had significantly higher FA, MD, and AD than inactive patients for medial EOMs (p < 0.005), whereas only FA differed significantly in the lateral EOMs (p = 0.018). The MD, AD, and RD of optic nerves were significantly lower in TAO patients than HCs (p < 0.05), except for FA (p = 0.129). Multivariate analysis showed that the MD of medial EOMs and disease duration were significant predictors for disease activity. The combination of these two parameters showed optimal diagnostic efficiency for disease activity (area under the curve, 0.855; sensitivity, 68.4%; specificity, 96.9%).CONCLUSION: rs-EPI-based DTI is promising in assessing microstructural changes of EOMs and optic nerves and can help to indicate the disease activity of TAO, especially through the MD of medial EOMs.


Subject(s)
Anisotropy , Diffusion Tensor Imaging , Diffusion , Echo-Planar Imaging , Humans , Logistic Models , Multivariate Analysis , Muscles , Negotiating , Optic Nerve , Orbit , Sensitivity and Specificity , Smoke , Smoking , Troleandomycin
6.
Article in Chinese | WPRIM | ID: wpr-826387

ABSTRACT

To compare the differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) between brucella spondylitis (BS) groups at different stages before treatment and the normal control group and to evaluate the change trend of ADC value and FA value at different time points before and after treatment. Totally 53 patients suspected of BS by conventional magnetic resonance imaging (MRI) and later confirmed as BS patients by serological tests were enrolled in this study. These patients underwent conventional MRI and diffusion tensor imaging scans,and the ADC value and FA value were measured. Independent sample test was used to compare the ADC value and FA value between the BS group and the control group,the ADC value and FA value between the BS group at each stage. Repeated measurement ANOV was used to compare the ADC values and FA values at different time points before and after treatment. FA imaging showed that the color code of BS was different from that of the normal control group,and the color code of FA imaging showed increased singal. The ADC values of BS in the acute,subacute,and chronic stages [(1.45±0.02)×10 mm /s,(1.35±0.03)×10 mm /s,(1.26±0.05)×10 mm /s,respectively] were significantly higher than those in the control group [(1.06±0.09) ×10 mm /s](=2.538,=0.009;=1.998,=0.032;=1.575,=0.004),and the FA value (0.55±0.02,0.65±0.03,0.71±0.04,respectively) were significantly lower than those of the control group (0.78±0.02) (=2.440,=0.012; =1.847,=0.041;=2.102,=0.003). Repeated measurement analysis showed that there were statistically significant differences in ADC values and FA values at different time points before and after treatment in the acute,subacute,and chronic stages (ADC:=12.100,<0.001;=8.439,=0.005;=9.704,=0.004,respectively;FA:=7.080,=0.002;=6.607;=0.003;=8.868,=0.001,respectively). The ADC values at different time points after treatment were significantly lower than those before treatment or at a previous time point after treatment (=332.14,<0.001),and the FA values were significantly higher than those before treatment or at a previous time point after treatment (=134.26,<0.001). FA color code can intuitively display differences in BS and normal vertebral bodies and show change of color code before and after treatment. Also,the ADC values and FA values can quantitatively reveal differences between BS and normal vertebral body in different time points and quantify BS vertebral lesion changes before and after treatment. In particular,in BS patients who are recovering from treatment,it can quantify microscopic edema. Therefore,diffusion tensor imaging may be useful objective indicator in evaluating the effectiveness of a specific treatment for BS.


Subject(s)
Anisotropy , Brucella , Brucellosis , Diagnostic Imaging , Diffusion Magnetic Resonance Imaging , Diffusion Tensor Imaging , Humans , Spondylitis , Diagnostic Imaging , Microbiology
7.
Article in Chinese | WPRIM | ID: wpr-828679

ABSTRACT

OBJECTIVE@#To study the value of fractional anisotropy (FA) of regions of interest (ROI) on magnetic resonance diffusion tensor imaging (DTI) in bilirubin-induced neurological dysfunction in neonates.@*METHODS@#A total of 91 neonates with hyperbilirubinemia who were hospitalized from January 2017 to January 2018 were enrolled. According to the peak level of total serum bilirubin, they were divided into three groups: mild/moderate increase (n=45), severe increase (n=35), and extremely severe increase (n=11). According to the presence or absence of abnormal neurological manifestations, they were divided into two groups: neurological dysfunction (n=20) and non-neurological dysfunction (n=71). Ten healthy full-term infants were enrolled as the control group. Head DTI was performed for all neonates to measure the FA values of the bilateral globus pallidus, the anterior limb of the internal capsule, the posterior limb of the internal capsule, and the cerebellar dentate nucleus.@*RESULTS@#The extremely severe increase group had significantly lower FA values of the globus pallidus than the control, mild/moderate increase, and severe increase groups (P<0.05). The severe increase group had significantly lower FA values of the globus pallidus than the control group (P<0.05). The extremely severe increase group had significantly lower FA values of the posterior limb of the internal capsule than the control, mild/moderate increase, and severe increase groups (P<0.05). The neurological dysfunction group had significantly lower FA values of the globus pallidus and the posterior limb of the internal capsule than the non-neurological dysfunction group (P<0.05).@*CONCLUSIONS@#Serum bilirubin level combined with the changes in the DTI FA values of the globus pallidus and the posterior limb of the internal capsule can be used to predict the injury of cerebral nuclei and white matter fibers.


Subject(s)
Anisotropy , Bilirubin , Brain , Diffusion Magnetic Resonance Imaging , Diffusion Tensor Imaging , Humans , Infant, Newborn , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , White Matter
8.
Rev. argent. radiol ; 83(3): 95-101, set. 2019. ilus, tab
Article in Spanish | LILACS | ID: biblio-1057407

ABSTRACT

Objetivo Desde la aparición de la tractografía, al tratarse de una técnica no invasiva y que usa la ampliamente conocida resonancia magnética (RM), el estudio de la sustancia blanca se ha facilitado. A partir de eso, se han logrado grandes descubrimientos en cuanto a fascículos cerebrales involucrados en funciones cognitivas. Sin embargo, su evaluación sigue siendo subjetiva y depende de la experiencia y entrenamiento del evaluador, razón por la cual se ha limitado su aplicabilidad en la práctica clínica. En ese sentido, es conveniente parametrizar volúmenes cerebrales de sustancia blanca en población sana a través de una herramienta electrónica que se pueda reproducir y así poderlo aplicar en enfermos. Materiales y métodos Se reportan 10 sujetos sanos desde el punto de vista neurológico. Para cada sujeto, se adquirieron imágenes ponderadas por difusión y los resultados se visualizaron mediante FiberNavigator (http://scilus.github.io/fibernavigator). Finalmente, esa misma herramienta fue utilizada para purificar los fascículos objeto de estudio y realizar el conteo de las fibras. Resultados Se obtuvieron valores de volumetría del fascículo longitudinal superior (FLS), fascículo longitudinal inferior (FLI), fascículo frontoccipital inferior (FFI), fascículo uncinado (FU) y fascículo del cíngulo (FC), identificando que no existen diferencias estadísticamente significativas entre el número de fibras que componen los fascículos cerebrales. Discusión Los resultados alcanzados de la anatomía y la direccionalidad de fibras de los fascículos cerebrales de este estudio coinciden con el resto de la evidencia publicada hasta el momento, sin encontrar diferencias en cuanto a su organización y recorrido. Conclusión Aunque esos resultados no sirven como valores de referencia para ser aplicados en pacientes con patología neurológica, brindamos información inexistente hasta el momento, con ese equipo en específico y la reproducción entre los distintos usuarios y el software.


Objective Since the appearance of tractography, as it is a non-invasive technique and uses the widely known magnetic resonance (MR), the study of white matter has been facilitated. After this, great discoveries have been made regarding the brain fascicles involved in cognitive functions. However, its evaluation continues to be subjective and depends on the evaluator's experience and training. That the reason why its applicability has been limited in clinical practice. Because of this, it is convenient to parametrize cerebral volumes of white matter in healthy population through an electronic, reproducible tool that could be applied in patients. Materials and Methods Ten neurologically healthy subjects are reported, for each subject we acquired images weighted by diffusion and the results were visualized by means of FiberNavigator (http://scilus.github.io/fibernavigator). Finally, this same tool was used to purify the fascicles under study and perform the fiber count. Results Volumetric values of the upper longitudinal fasciculus, inferior longitudinal fasciculus, inferior frontoccipital fasciculus, uncinated fasciculus and cingulate fasciculus were obtained, identifying that there are not statistically significant differences in the number of fibers that make up the cerebral fascicles. Discussion The results achieved of the anatomical and fiber directionality of the cerebral fascicles of this study, coincide with the rest of the evidence published up to now, without finding differences regarding its organization and route. Conclusion Although these results do not serve as reference values to be applied in patients with neurological pathology, do we provide nonexistent information so far, with this specific equipment and the reproducibility between the different users and the software.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Young Adult , Cognition/physiology , White Matter/diagnostic imaging , Reference Values , Anisotropy , Titrimetry/standards , Diffusion Tensor Imaging/standards , Nerve Fibers
9.
Rev. med. (Säo Paulo) ; 98(4): 259-266, jul.-ago. 2019. ilus
Article in English | LILACS | ID: biblio-1023529

ABSTRACT

It is increasingly recognised that dysfunction in neural circuits plays a key role in the neurobiological basis of mental disorders. The efficacy of pharmacological and behavioural treatments for mental disorders could therefore be improved by targeting dysfunctions in neurocircuits. However, to achieve this, a better understanding of the specific alterations in neural circuits involved in different mental disorders is required. Such understanding can be acquired by using advanced neuroscience methods to examine the pathways and function of neurocircuits in both typically developing individuals and in those with mental disorders. This article provides an overview of currently available neuroscience methods of investigating neural circuits, including advantages and limitations of different techniques, and highlights the importance of using multi-modal imaging in future research.


É cada vez mais reconhecido que a disfunção nos circuitos neurais desempenha um papel fundamental na base neurobiológica dos transtornos mentais. A eficácia dos tratamentos farmacológicos e comportamentais para os transtornos mentais pode, portanto, ser melhorada por direcionar as disfunções nos neurocircuitos. No entanto, para isso, é necessário um melhor entendimento das alterações específicas nos circuitos neurais envolvidos em diferentes transtornos mentais. Tal entendimento pode ser adquirido usando-se métodos avançados de neurociência para examinar as vias e a função dos neurocircuitos em indivíduos com desenvolvimento típico e naqueles com transtornos mentais. Este artigo fornece uma visão geral dos métodos da neurociência atualmente disponíveis na investigação de circuitos neurais, incluindo vantagens e limitações de diferentes técnicas, e destaca a importância do uso de imagens multimodais em pesquisas futuras.


Subject(s)
Magnetic Resonance Imaging , Electroencephalography , Diffusion Tensor Imaging , Multimodal Imaging , Mental Disorders
10.
Rev. argent. neurocir ; 33(2): 73-81, jun. 2019. ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1177669

ABSTRACT

Introducción: La estimulación cerebral profunda es una técnica difundida y validada para eltratamiento de múltiples dolencias neurológicas y psiquiátricas, entre ellas el temblor esencial. Objetivo: Evaluar si existe un correlato clínico-anatómico, para un paciente con TE, entre la mejor estimulación lograda y los tractos involucrados. Para esto se realiza una descripción de la técnica utilizada, incluyendo el procesamiento de imágenes necesario. Material y métodos: Se presenta el caso de un paciente de 53 años de edad, con una historia de 23 años de temblor esencial progresivo e incapacitante. Se realizó un implante de DBS bilateral en Vim. Se realizó un post procesamiento de imágenes con un método desarrollado por nuestro equipo a través del cual se permitió evaluar gráficamente el área de estimulación cerebral y sus relaciones con los tractos implicados en la patología (dento-rubro-talámico, haz piramidal y haz lemniscal). Resultados: El paciente presentó una mejoría del 55% medido por escala de temblor de Tolosa. Se obtuvo una correlación anatómica y funcional de lo esperado según imágenes y la respuesta clínica del paciente. Se constataron efectos adversos cuando la estimulación implicaba fibras del haz piramidal y lemniscal, presentando los mejores efectos clínicos cuando el haz dento-rubro-talámico era influenciado por el área de acción del campo eléctrico. Conclusiones: En este reporte mostramos la aplicabilidad de DTI y tractografía para explicar los efectos de la programación de los pacientes con estimulación cerebral profunda.


Introduction: Deep brain stimulation is a widespread and validated technique for the treatment of multiple neurological and psychiatric disorders, including essential tremor. Objective: To evaluate if there is a clinical-anatomical correlate, for a patient with essential tremor, between the best stimulation achieved and the tracts involved. For this, a description of the technique used is made, including the necessary image processing. Methods: We present the case of a 53-year-old patient with a 23-year history of progressive and disabling essential tremor. A bilateral DBS implant was performed on Vim. We performed a post-processing of images with a method developed by our team through which we were able to graphically evaluate the area of brain stimulation and its relationships with the tracts involved in the pathology (dento-rubro-thalamic tract, pyramidal tract and lemniscal tract). Conclusions: In this report we showed the applicability of DTI and tractography to explain the clinical effects of the programming features in patients with deep brain stimulation.


Subject(s)
Transcutaneous Electric Nerve Stimulation , Essential Tremor , Diffusion Tensor Imaging , Mental Disorders
12.
Article in English | WPRIM | ID: wpr-740164

ABSTRACT

PURPOSE: Diffusion tensor imaging (DTI) data must be analyzed by an analyzer after data processing. Hence, the analyzed data of DTI might depend on the analyzer, making it a major limitation. This paper reviewed previous DTI studies reporting the repeatability and reproducibility of data from the corticospinal tract (CST), one of the most actively researched neural tracts on this topic. MATERIALS AND METHODS: Relevant studies published between January 1990 and December 2018 were identified by searching PubMed, Google Scholar, and MEDLINE electronic databases using the following keywords: DTI, diffusion tensor tractography, reliability, repeatability, reproducibility, and CST. As a result, 15 studies were selected. RESULTS: Measurements of the CSTs using region of interest methods on 2-dimensional DTI images generally showed excellent repeatability and reproducibility of more than 0.8 but high variability (0.29 to 1.00) between studies. In contrast, measurements of the CST using the 3-dimensional DTT method not only revealed excellent repeatability and reproducibility of more than 0.9 but also low variability (repeatability, 0.88 to 1.00; reproducibility, 0.82 to 0.99) between studies. CONCLUSION: Both 2-dimensional DTI and 3-dimensional DTT methods appeared to be reliable for measuring the CST but the 3-dimensional DTT method appeared to be more reliable.


Subject(s)
Diffusion Tensor Imaging , Diffusion , Methods , Pyramidal Tracts
13.
Experimental Neurobiology ; : 300-310, 2019.
Article in English | WPRIM | ID: wpr-739536

ABSTRACT

Over the years, diffusion tractography has seen increasing use for comparing minute differences in connectivity of brain structures in neurodegenerative diseases and treatments. Studies on connectivity between basal ganglia has been a focal point for studying the effects of diseases such as Parkinson's and Alzheimer's, as well as the effects of treatments such as deep brain stimulation. Additionally, in previous studies, diffusion tractography was utilized in disease mouse models to identify white matter alterations, as well as biomarkers that occur in the progression of disease. However, despite the extensive use of mouse models to study model diseases, the structural connectivity of the mouse basal ganglia has been inadequately explored. In this study, we present the methodology of segmenting the basal ganglia of a mouse brain, then generating diffusion tractography between the segmented basal ganglia structures. Additionally, we compare the relative levels of connectivity of connecting fibers between each basal ganglia structure, as well as visualize the shapes of each connection. We believe that our results and future studies utilizing diffusion tractography will be beneficial for properly assessing some of the connectivity changes that are found in the basal ganglia of various mouse models.


Subject(s)
Animals , Basal Ganglia , Biomarkers , Brain , Deep Brain Stimulation , Diffusion Tensor Imaging , Diffusion , Magnetic Resonance Imaging , Mice , Neurodegenerative Diseases , White Matter
14.
Article in English | WPRIM | ID: wpr-739332

ABSTRACT

Diffusion tensor imaging (DTI) has a diagnostic value in cervical myelopathy. The usefulness of diffusion metrics as a potential prognostic biomarker was assessed in this review. Various diffusion metrics, such as fractional anisotropy, mean diffusivity, apparent diffusion coefficient, and radial diffusivity, were significant in correlation with functional recovery after surgery. Changes in diffusion metrics not only at the compression level, but also above and below the compression level were confirmed. However, it was difficult to confirm the results owing to the diversity of studies. Further efforts to make a consensus on spinal cord DTI are needed.


Subject(s)
Anisotropy , Consensus , Diffusion Tensor Imaging , Diffusion , Recovery of Function , Spinal Cord , Spinal Cord Diseases
15.
Article in English | WPRIM | ID: wpr-785690

ABSTRACT

BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is the most common cause of vascular dementia and a major contributor to mixed dementia. CSVD is characterized by progressive cerebral white matter changes (WMC) due to chronic low perfusion and loss of autoregulation. In addition to its antiplatelet effect, cilostazol exerts a vasodilating effect and improves endothelial function. This study aims to compare the effects of cilostazol and aspirin on changes in WMC volume in CSVD.METHODS: The comparison study of Cilostazol and aspirin on cHAnges in volume of cerebral smaLL vEssel disease white matter chaNGEs (CHALLENGE) is a double blind, randomized trial involving 19 hospitals across South Korea. Patients with moderate or severe WMC and ≥ 1 lacunar infarction detected on brain magnetic resonance imaging (MRI) are eligible; the projected sample size is 254. Participants are randomly assigned to a cilostazol or aspirin group at a 1:1 ratio. Cilostazol slow release 200 mg or aspirin 100 mg are taken once daily for 2 years. The primary outcome measure is the change in WMC volume on MRI from baseline to 104 weeks. Secondary imaging outcomes include changes in the number of lacunes and cerebral microbleeds, fractional anisotropy and mean diffusivity on diffusion tensor imaging, and brain atrophy. Secondary clinical outcomes include all ischemic strokes, all vascular events, and changes in cognition, motor function, mood, urinary symptoms, and disability.CONCLUSIONS: CHALLENGE will provide evidence to support the selection of long-term antiplatelet therapy in CSVD.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01932203


Subject(s)
Anisotropy , Aspirin , Atrophy , Brain , Cerebral Small Vessel Diseases , Cognition , Dementia , Dementia, Vascular , Diffusion Tensor Imaging , Homeostasis , Humans , Korea , Magnetic Resonance Imaging , Outcome Assessment, Health Care , Perfusion , Sample Size , Stroke , Stroke, Lacunar , White Matter
16.
Article in Chinese | WPRIM | ID: wpr-774125

ABSTRACT

GM1 gangliosidosis is an autosomal recessive disorder caused by galactosidase beta1 (GLB1) gene variants which affect the activity of β-galactosidase (GLB). GLB dysfunction causes abnormalities in the degradation of GM1 and its accumulation in lysosome. This article reports the clinical and genetic features of a child with GM1 gangliosidosis. The girl, aged 2 years and 5 months, was referred to the hospital due to motor developmental regression for more than one year. Physical examination showed binocular deflection and horizontal nystagmus, but no abnormality was found on fundoscopy. The girl had increased muscular tone of the extremities, limitation of motion of the elbow, knee, and ankle joints, and hyperactive patellar tendon reflex. Blood biochemical examination showed a significant increase in aspartate aminotransferase. The 24-hour electroencephalographic monitoring detected frequent seizure attacks and diffuse θ wave activity, especially in the right hemisphere. Head magnetic resonance imaging showed thinner white matter in the periventricular region and diffuse high T2WI signal with unclear boundary. Three-dimensional reconstruction of white matter fiber tracts by diffusion tensor imaging showed smaller and thinner white matter fiber tracts, especially in the right hemisphere. Genetic analysis showed that the girl had compound heterozygous mutations of c.446C>T (p.Ser149Phe) and c.101T>C (p.Ile34Thr) in the GLB1 gene from her parents, among which c.101T>C (p.Ile34Thr) had not been reported in the literatures. The girl was finally diagnosed with GM1 gangliosidosis. Her conditions were not improved after antiepileptic treatment and rehabilitation training for 2 months.


Subject(s)
Diffusion Tensor Imaging , Female , Gangliosidosis, GM1 , Genetics , Humans , Infant , Mutation , Virulence , beta-Galactosidase , Genetics
17.
Article in Chinese | WPRIM | ID: wpr-775865

ABSTRACT

OBJECTIVE@#To explore the effectiveness and safety of the combined treatment with acupuncture and venlafaxine hydrochloride on depression in terms of the microstructure change of white matter fiber tracts of brain based on diffusion tensor imaging technology (DTI).@*METHODS@#The prospective study design was adopted. All of 60 patients with depression were randomized into an acupuncture-medication group and a medication group, 30 cases in each one. In the medication group, venlafaxine hydrochloride was used, 75 mg per day in the 1st week, 150 mg per day in the 2nd week and 225 mg per day from the 3rd to 6th week. In the acupuncture-medication group, on the base of the treatment in the medication group, acupuncture was combined. Baihui (GV 20) and Yintang (GV 29) were the main acupoints. The supplementary acupoints were selected according to the clinical symptoms of individuals. The needles were retained for 30 min. Acupuncture was provided once every 2 days, 3 times a week. The consecutive 12 weeks of treatment were required in the two groups. Additionally, a normal group was prepared with 30 healthy volunteers. Separately, before treatment, in 2, 8 and 12 weeks of treatment, Hamilton's depression scale (HAMD-17), Beck depression inventory scale (BDI) and the antidepressant side effect scale (SERS) were adopted to evaluate the effectiveness and safety of the two groups. Moreover, before and after 12 weeks of treatment, DTI was adopted to detect the fractional anisotropy score (FA) of each brain region in the patients.@*RESULTS@#After treatment, the scores of HAMD-17 and BDI were all reduced in the two groups (0.05). Compared with the healthy volunteers, FA scores in 6 brain regions changed obviously in the patients with depression, including the white matter of bilateral frontal lobes, splenium of corpus callosum, left cingulated gyrus, white matter of bilateral inferior temporal gyrus, white matter of bilateral inferior parietal lobe and white matter of bilateral deep temporal occipital region separately. Before treatment, the differences in FA scores of these 6 brain regions were not significant statistically between the two groups (>0.05). After treatment, FA scores in the white matter of bilateral frontal lobes, white matter of bilateral inferior temporal gyrus and white matter of bilateral deep temporal occipital region in the acupuncture-medication group were all higher than those in the medication group (<0.05).@*CONCLUSION@#Acupuncture repairs the brain white matter fiber tracts in some brain regions to certain extent and the therapeutic effects are enhanced with the adjuvant medication of venlafaxine hydrochloride.


Subject(s)
Acupuncture Therapy , Brain , Depression , Therapeutics , Diffusion Tensor Imaging , Humans , Prospective Studies , Venlafaxine Hydrochloride
18.
Article in Chinese | WPRIM | ID: wpr-775843

ABSTRACT

OBJECTIVE@#Quantitative assessment of white blood flow in semi-oval center of patients with delayed neuropathological sequelae (DNS) after carbon monoxide poisoning treated with acupuncture combined with hyperbaric oxygen (HBO) based on magnetic resonance multi-inversion time arterial spin labeling imaging (mTI-ASL), and to evaluate its efficacy indirectly.@*METHODS@#Twenty-six patients with clinically diagnosed DNS were randomly divided into an observation group (13 cases) and a control group (13 cases). The conventional therapy combined with HBO were given in the control group. In the observation group,on the base of the treatment, acupuncture was applied, the main acupoints were Shuigou (GV 26), Neiguan (PC 6), Baihui (GV 20), Shangxing (GV 23), Yintang (GV 29), Sanyinjiao (SP 6) on the affected side, Sishencong (EX-HN 1), Fenglong (ST 40), Lianquan (CV 23) and Jinjin (EX-HN12) for slurred speech, Jianyu (LI 15), Waiguan (TE 5) and Shousanli (LI 10) for upper limb pain, Huantiao (GB 30), Yanglingquan (GB 34), Yinlingquan (SP 9) for lower limb pain, the treatment was given once every day, 5 days as one course, with an interval of 2 days between the course. The treatment for 6 courses was required. The conventional head MR scan, mTI-ASL and diffusion tensor imaging (DTI) scans before and 1 week after treatment were adopted, Matlab (R2014b), Mricron and Syngo.via software were adopted to measure the cerebral blood flow (CBF) and anisotropy (FA) values of the semi-oval center. The correlation between the parameters was evaluated by Pearson method. And the simple intelligent mental state examination scale (MMSE) was uesd to assess cognitive function.@*RESULTS@#After treatment, the CBF, MMSE scores in both groups and FA values in the observation group were higher than those before treatment (<0.05). After treatment, the CBF, FA and MMSE scores in the observation group were significantly higher than those in the control group (<0.05). There was a positive correlation between CBF, FA and MMSE scores (<0.05), and the correlation between CBF and MMSE was the best ( =0.822).@*CONCLUSION@#Acupuncture combined with hyperbaric oxygen can significantly improved early white matter hypoperfusion and improved cognitive function score in patients with DNS. The curative effect is better than that of hyperbaric oxygen therapy alone. The mTI-ASL imaging can quantitatively evaluate its curative effect.


Subject(s)
Acupuncture Therapy , Carbon Monoxide Poisoning , Diffusion Tensor Imaging , Humans , Hyperbaric Oxygenation
19.
Article in Chinese | WPRIM | ID: wpr-813275

ABSTRACT

To explore the mechanism for changes in brain microstructure in long-term abstinent from methamphetamine-dependence by using the diffusion tensor imaging (DTI).
 Methods: A total of 26 patients with long-term abstinent methamphetamine-dependence, whose abstinence time more than 14 months, and 26 normal controls all underwent cognitive executive function tests and DTI scans. We used voxel-based analysis to compare the fractional anisotropy (FA) and mean diffusivity (MD) to obtain the abnormal brain regions of DTI parameters between the two groups. Spearman correlation analysis was used to explore the correlation between FA, MD of the brain regions with abnormal parameters and cognitive executive function tests.
 Results: There were no statistical differences in the cognitive executive function tests between the two groups (P>0.05). Compared with the normal control group, the long-term abstinent from methamphetamine-dependence group showed the decreased FA in the right precuneus, right superior frontal gyrus, right calcarine, left inferior temporal gyrus and the increased MD in the right triangular part of inferior frontal gyrus, right precuneus, right posterior cingulate, right middle temporal gyrus, bilateral middle occipital gyrus, left superior parietal lobule, and lobule VIII of cerebellar hemisphere. The MD values of the right middle temporal gyrus in the long-term abstinent group were negatively correlated with the number of completions within 60 seconds (r=-0.504) and within 120 seconds (r=-0.464) .
 Conclusion: The DTI parameters in multiple brain regions from the methamphetamine-dependence patients are still abnormal after a long-term abstinence. DTI can provide imaging evidence for brain microstructural abnormalities in long-term abstinent from methamphetamine-dependence.


Subject(s)
Amphetamine-Related Disorders , Anisotropy , Brain , Diffusion Tensor Imaging , Humans , Methamphetamine
20.
Article in Chinese | WPRIM | ID: wpr-813272

ABSTRACT

Obstructive sleep apnea is often accompanied by functional changes in attention, alertness, long-term vision and language memory, visual space/structural competence, and executive function due to long-term intermittent hypoxia, high blood carbonate, and sleep structure disorders. In recent years, some scholars have found that the changes of brain structure, metabolism and function revealed by static functional magnetic resonance imaging (MRI) are closely related to the changes of cognitive function reflected in the cognitive function evaluation scale. In recent years, static functional magnetic resonance, especially voxel-based morphometry, diffusion tensor imaging, magnetic resonance spectroscopy and functional magnetic resonance imaging have confirmed significant changes in brain structure, metabolism and function in OSA patients, and the changes are closely related to the changes of cognitive function reflected in the cognitive function evaluation scale. It is great significance to study the mechanism of cognitive function change in OSA patients, and helpful to the early diagnosis and treatment as well as the evaluation of clinical efficacy.


Subject(s)
Cognition , Cognition Disorders , Diffusion Tensor Imaging , Humans , Magnetic Resonance Spectroscopy , Sleep Apnea, Obstructive , Diagnostic Imaging
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