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1.
Article in English | WPRIM | ID: wpr-878376

ABSTRACT

Climate change has been referred to as one of the greatest threats to human health, with reports citing likely increases in extreme meteorological events. In this study, we estimated the relationships between temperature and outpatients at a major hospital in Qingdao, China, during 2015-2017, and assessed the morbidity burden. The results showed that both low and high temperatures were associated with an increased risk of outpatient visits. High temperatures were responsible for more morbidity than low temperatures, with an attributed fraction (AF) of 16.86%. Most temperature-related burdens were attributed to moderate cold and hot temperatures, with AFs of 5.99% and 14.44%, respectively, with the young (0-17) and male showing greater susceptibility. The results suggest that governments should implement intervention measures to reduce the adverse effects of non-optimal temperatures on public health-especially in vulnerable groups.


Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Ambulatory Care/statistics & numerical data , Cardiovascular Diseases/therapy , Child , Child, Preschool , China/epidemiology , Cold Temperature/adverse effects , Cost of Illness , Digestive System Diseases/therapy , Facilities and Services Utilization/statistics & numerical data , Female , Hot Temperature/adverse effects , Humans , Infant , Infant, Newborn , Male , Middle Aged , Poisson Distribution , Respiratory Tract Diseases/therapy , Risk Factors , Young Adult
2.
Article in Korean | WPRIM | ID: wpr-84305

ABSTRACT

Adult stem cells are multipotent and self-renewing cells that contain several functions; i) migration and homing potential: stem cells can migrate to injured and inflamed tissues. ii) differentiation potential: stem cells which migrated to injured tissues can be differentiated into multiple cell types for repairing and regenerating the tissues. iii) immunomodulatory properties: stem cells, especially mesenchymal stem cells can suppress immune system such as inflammation. All those characteristics might be useful for the treatment of the digestive tract diseases which are complex and encompass a broad spectrum of different pathogenesis. Preclinical stem cell therapy showed some promising results, especially in liver failure, pancreatitis, sepsis, and inflammatory bowel disease. If we can understand more about the mechanism of stem cell action, stem cell therapy can become a promising alternative treatment for refractory digestive disease in the near future. In this review, we summarized current preclinical experiences in diseases of the digestive tract using stem cells.


Subject(s)
Adult Stem Cells/cytology , Digestive System Diseases/therapy , Drug Evaluation, Preclinical , Humans
3.
Article in Korean | WPRIM | ID: wpr-84304

ABSTRACT

Many techniques for isolation, expansion and handling of stem cells are being developed rapidly, and preclinical evidence has shown the possibility to use this technology for refractory diseases in the near future. Among refractory digestive diseases, Crohn's disease and liver cirrhosis may be two main diseases where stem cell therapy can be applied for anti-inflammation and regeneration of tissue. Currently, with respect to these two diseases, clinical trials using hematopoietic stem cells and mesenchymal stem cells from bone marrow or adipose tissue have shown some evidence of clinical benefits to immune modulation, suppression of inflammation and regeneration of functional cells. However, for the development of practical stem cell therapy, we need more data on underlying mechanisms, effective subpopulation of stem cells and its sources, and effective parameters for monitoring and estimation. With technical advances, the research on embryonic and induced pluripotent stem cells will also contribute to the new therapeutic strategies for digestive regenerative medicine. In the future, a variety of stem cell therapies may be therapeutic options for refractory digestive diseases, but many technical challenges remain to be solved.


Subject(s)
Bone Marrow Cells/cytology , Clinical Trials as Topic , Crohn Disease/therapy , Digestive System Diseases/therapy , Hematopoietic Stem Cell Transplantation , Hematopoietic Stem Cells/cytology , Humans , Liver Cirrhosis/therapy , Mesenchymal Stem Cells/cytology
4.
Indian J Pediatr ; 2008 Jun; 75(6): 621-7
Article in English | IMSEAR | ID: sea-81884

ABSTRACT

Probiotics are "live microbes which when administered in adequate amounts confer a health benefit to the host" (FAO/WHO joint group). Their potential role in bio-ecological modification of pathological internal milieu of the critically ill is under evaluation. Probiotics are available as single microbial strain (e.g., Bacillus clausii, Lactobacillus) or as a mix of multiple strains of Lactobacillus (acidophilus, sporogenes, lactis, reuteri RC-14, GG, and L. plantarum 299v), Bifidobacterium (bifidum, longum, infantis), Streptococcus (thermophillus, lactis, fecalis), Saccharomyces boulardii etc. Lactobacilli and Bifidobacteria are gram-positive, anaerobic, lactic acid bacteria. These are normal inhabitant of human gut and colonize the colon better than others. Critical illness and its treatment create hostile environment in the gut and alters the micro flora favoring growth of pathogens. Therapy with probiotics is an effort to reduce or eliminate potential pathogens and toxins, to release nutrients, antioxidants, growth factors and coagulation factors, to stimulate gut motility and to modulate innate and adaptive immune defense mechanisms via the normalization of altered gut flora. Scientific evidence shows that use of probiotics is effective in prevention and therapy of antibiotic associated diarrhea. However, available probiotics strains in currently used doses do not provide much needed early benefits, and need long-term administration to have clinically beneficial effects (viz, a reduction in rate of infection, severe sepsis, ICU stay, ventilation days and mortality) in critically ill surgical and trauma patients. Possibly, available strains do not adhere to intestinal mucosa early, or may require higher dose than what is used. Gap exists in our knowledge regarding mechanisms of action of different probiotics, most effective strains--single or multiple, cost effectiveness, risk-benefit potential, optimum dose, frequency and duration of treatment etc. More information is needed on safety profile of probiotics in immunocompromised state of the critically ill in view of rare reports of fungemia and sepsis and a trend toward possible increase in nosocomial infection. At present, despite theoretical potential benefits, available evidence is not conclusive to recommend probiotics for routine use in the critically ill.


Subject(s)
Critical Illness/therapy , Digestive System Diseases/therapy , Gastrointestinal Tract/microbiology , Humans , Probiotics/pharmacology
5.
In. Cimerman, Sérgio; Cimerman, Benjamim. Condutas em infectologia. São Paulo, Atheneu, 2004. p.467-473.
Monography in Portuguese | SES-SP, LILACS, SES-SP | ID: lil-407442
6.
RBM rev. bras. med ; 57(6): 629-634, jun. 2000. tab, graf
Article in Portuguese | LILACS | ID: lil-328344

ABSTRACT

A síndrome dispéptica se refere a um distúrbio que produz queixas abdominais superiores geralmente intermitentes, cujas causas näo podem ser determinadas pela avaliaçäo clínica. No seu tratamento têm sido empregados vários tipos de medicamentos, inclusive os complementos enzimáticos, os quais apresentam boa eficácia terapêutica. Em um estudo colaborativo, aberto, näo comparativo foi avaliada a resposta clínica de 143 pacientes portadores de sintomas dispépticos ao tratamento com um complemento enzimático à base de Aspergillusorizae, pancreatina e bile bovina - Combizym Composto -, na posologia de uma drágea três vezes ao dia por duas semanas. O diagnóstico mais prevalente foi o de dispepsia multifatorial, seguido de disfunçäo gastrointestinal e de disfunçäo biliar. Em 96 casos foi feito apenas um diagnóstico, enquanto que 24 pacientes apresentaram dois diagnósticos e os restantes três ou até quatro diagnósticos. Cento e oito pacientes foram submetidos a uma dieta, sendo 74 a uma dieta hipogordurosa, 24 a uma dieta hipogordurosa associada com fibras e os restantes 10 casos a uma dieta rica em fibras. A avaliaçäo da sintomatologia antes e após o tratamento demonstra uma excelente evoluçäo do quadro clínico. Os principais sintomas - distençäo abdominal, flatulência, eructaçäo, Náusea, vômitos e dor abdominal - desapareceram ou apresentaram melhora em mais de 93 porcento dos casos. Os sintomas constipaçäo intestinal e anorexia foram os que apresentaram evoluçäo menos acentuada, embora os resultados sejam considerados bons. A avaliaçäo final do tratamento pelos investigadores foi de 95,1 porcento como ótima e boa e pelos pacientes foi de 92,3 porcento. A tolerabilidade foi excelente, sendo que apenas 7 porcento dos casos apresentaram eventos adversos de leve intensidade, quase todos ligados à doença de base. Os resultados do presente estudo confirmam os obtidos por vários autores e demonstram que o complemento enzimático Combizym Composto atua eficazmente em todos os sintomas da síndrome dispéptica, com excelente tolerabilidade(au)


Subject(s)
Humans , Male , Female , Adult , Aspergillus oryzae , Digestive System Diseases/therapy , Drug Combinations , Dyspepsia , Pancreatin , Gastrointestinal Diseases
7.
Mundo saúde (Impr.) ; 24(2): 144-50, mar.-abr. 2000.
Article in Portuguese | LILACS | ID: lil-264207

ABSTRACT

A introdução de novos medicamentos para o tratamento de doenças do trato digestório foi marcante para a terapia de patologias que antes necessitavam de intervenção cirúrgica. Os antagonistas de receptores H2 de histamina; os inibidores da bomba de próton; os compostos de bismuto; o sucralfato; os análogos de prostaglandinas associados aos antibióticos claritromicina e amoxicilina somaram-se aos antiácidos para o tratamento da úlcera péptica, do refluxo gastro-esofágico e de lesões da mucosa gástrica produzidas pelo uso crônico de antiinflamatórios não esteroidais. Contudo, recentes descobertas estão trazendo novas perspectivas para a farmacologia do sistema digestório, inclusive a utilização do óxido nítrico e de outras citocinas, da vacina contra a bactéria Helicobacter pylori e dos agentes bioterapêuticos


Subject(s)
Digestive System Diseases/drug therapy , Digestive System Diseases/pathology , Digestive System Diseases/physiopathology , Digestive System Diseases/therapy , Gastric Mucosa , Gastric Mucosa/injuries , Gastric Mucosa/pathology , Gastroesophageal Reflux/drug therapy , Gastroesophageal Reflux/therapy , Peptic Ulcer/drug therapy , Peptic Ulcer/therapy
8.
Trib. méd. (Bogotá) ; 97(3): 103-14, mar. 1998. ilus, tab, graf
Article in Spanish | LILACS | ID: lil-294003

ABSTRACT

Cuando se presentan pirosis rebeldes, diarrea aguda o aparece anemia por deficiencia de hierro, existe entre los médicos la tendencia a estudiar al enfermo de modo excesivo, a darle tratamiento poco apropiado o en algunas acasiones, a confundir el cuadro con otros similares. Este artículo intenta ayudar a evitar esas situaciones


Subject(s)
Humans , Male , Female , Adult , Digestive System Diseases/diagnosis , Digestive System Diseases/etiology , Digestive System Diseases/therapy
9.
Acta méd. (Porto Alegre) ; (1): 187-95, 1995.
Article in Portuguese | LILACS | ID: lil-198407

ABSTRACT

Os autores realizam uma revisäo bibliográfica sobre constipaçäo, abordando os aspectos etiológicos e os mais recentes meios diagnósticos para o problema


Subject(s)
Humans , Constipation/diagnosis , Constipation/etiology , Digestive System Diseases/diagnosis , Digestive System Diseases/etiology , Digestive System Diseases/therapy
10.
Medicina (Ribeiräo Preto) ; 25(4): 489-97, out.-dez. 1992.
Article in Portuguese | LILACS | ID: lil-127635

ABSTRACT

Esta revisäo aborda as mais frequentes urgências gastroenterológicas (hemorragia digestiva alta, pancreatite, insuficiência hepática aguda, peritonite bacteriana espontânea e encefalopatia hepática) na prática clínica, com ênfase em aspectos diagnósticos e terapêuticos


Subject(s)
Humans , Digestive System Diseases/diagnosis , Emergencies , Hepatic Encephalopathy/diagnosis , Gastrointestinal Hemorrhage/diagnosis , Liver Diseases/diagnosis , Pancreatitis/diagnosis , Peritonitis/diagnosis , Ascitic Fluid , Digestive System Diseases/etiology , Digestive System Diseases/therapy , Hepatic Encephalopathy/etiology , Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/therapy , Liver Diseases/etiology , Pancreatitis/therapy , Peritonitis/etiology , Peritonitis/therapy , Signs in Homeopathy , Symptoms in Homeopathy
11.
Diagnóstico (Perú) ; 29(3/4): 46-50, mar.-abr. 1992. tab
Article in Spanish | LIPECS, LILACS, LIPECS | ID: lil-483660

ABSTRACT

Se realizó este estudio prospectivo, en 784 gestantes atendidas en la consulta externa del Departamento de Gineco-Obstetricia del Hospital Cayetano Heredia de Lima, en los meses de Febrero y Marzo de 1990, con la finalidad de conocer la incidencia de enfermedades digestivas asociadas al embarazo y aportar con algunas pautas en su manejo terapéutico. En todos los casos, se realizaron exámenes de laboratorio, ecografías abdominal y pélvica, y en los casos atribuibles a Reflujo gastroesofágico, fueron sometidas al exámen endoscópico digestivo alto. Los resultados fueron: 73 casos, de las 784 gestantes (9.3 por ciento), presentaban dolencias digestivas. De estos 73 casos, se hallaron: estreñimiento en 49 casos (67.1 por ciento), reflujo gastroesofágico 12 casos (16.4 por ciento); hiperemesis gravídica 11 casos (15 por ciento), y pancreatitis aguda un caso (1.3 por ciento). No se detectaron casos con enfermedades hepáticas. Los 12 casos con reflujo gastroesofágico, fueron tratados con dieta y suspención oral que contenian antiácidos y alginato de magnesio. En 10 de estos casos, se obtuvo buena respuesta terapéutica. La endoscopía digestiva brindó efectividad diagnóstica, sin ninguna complicación obstétrica. El estudio mostró una incidencia habitual de estas enfermedades en el embarazo; las que en su mayor parte no son de grado severo; salvo las Pancreatitis agudas, que en nuestro caso evolucionó favirablemente. Las enfermedades hepáticas no detectables en este grupo de gestantes, si constituyen en ciertos casos, problemas en su manejo terapéutico. Ha de ser interesante desarrollar estudios similares en el futuro para confirmar estos resultados, en poblaciones de gestantes de Lima y otras ciudades del Perú.


Subject(s)
Humans , Female , Pregnancy , Digestive System Diseases/diagnosis , Digestive System Diseases/urine , Digestive System Diseases/drug therapy , Digestive System Diseases , Digestive System Diseases/blood , Digestive System Diseases/therapy
12.
ABCD arq. bras. cir. dig ; 6(4): 78-81, out.-dez. 1991. tab
Article in English | LILACS | ID: lil-112586

ABSTRACT

Foram estudados 140 pacientes submetidos a cirurgias eletivas, divididos em dois grupos: 70 com e 70 sem sonda nasogastrica. No pre-operatorio todos os pacientes foram submetidos a uma anamnese e exame fisico detalhados, radiografia de torax e seios paranasais, dosagem serica de sodio, potassio e bicabornato, e endoscopia digestiva alta. Houve prevalencia de afeccoes das vias aereas no grupo com sonda nasogastrica. Neste mesmo grupo, 26 pacientes foram submetidos a endoscopia digestiva alta, onde se constatou lesoes traumaticas e esofagite em 92 por cento, em comparacao com 23 pacientes do grupo sem sonda nasogastrica que apresentaram, em 91 por cento das endoscopias, um resultado normal.


Subject(s)
Digestive System Diseases/therapy , Intubation, Gastrointestinal/adverse effects , Endoscopy, Digestive System , Postoperative Care
14.
Rev. gastroenterol. Méx ; 51(1): 29-33, ene.-mar. 1986. tab
Article in Spanish | LILACS | ID: lil-61227

ABSTRACT

Se realizó una revisión retrospectiva de 231 pacientes tratados con diversos métodos de nutrición artifical con el objeto de valorar los resultados obtenidos desde la creación del departamento de nutrición artificial a mediados de 1982 hasta noviembre de 1984. De ellos 138 fueron hombres y 93 mujeres, la patología que requirió apoyo nutricional con más frecuencia fue la gastrointestinal con 215 pacientes, en de los que 50 fueron portadores de neoplasias gastrointestinales diversas. Se administró nutrición parenteral total por vía central a 152 enfermos, dieta elemental a 45, terapia mixta, enteral y parenteral a 22, y terapia ahorradora de proteínas a solo 12 pacientes. La duración de nutrición artificial en promedio fue de 20 días por enfermo. Lograron sobrevivir un total de 155 pacientes (67%) y murieron durante la etapa de nurtición 76 (33%). Se hacen comentarios con respecto a los diversos patrones, tanto desde el punto de vista médico como administrativo para tratar de mejorar la calidad de este tipo de terapéutica


Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Body Weight , Cost-Benefit Analysis , Digestive System Diseases/therapy , Digestive System Neoplasms/therapy , Food, Formulated , Parenteral Nutrition , Postoperative Care , Radiography, Thoracic , Stomach Neoplasms/therapy , Pancreatitis/therapy
16.
In. Sosa Alvarez, Alberto. Actualizaciones en clínica geriátrica: 1er. ciclo 1983. Montevideo, Uruguay. Ministerio del Interior, 1984. p.19-26.
Monography in Spanish | LILACS | ID: lil-182086
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