Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 704
Filter
1.
Diagn. tratamento ; 29(1): 11-13, jan-mar. 2024.
Article in Portuguese | LILACS, SES-SP | ID: biblio-1551769
2.
Psicol. ciênc. prof ; 43: e253358, 2023.
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1448953

ABSTRACT

Este artigo realiza um percurso histórico das narrativas teóricas construídas pelas elites intelectuais brancas brasileiras sobre as relações raciais no campo psicológico, bem como os efeitos desse processo no desenvolvimento da psicologia enquanto ciência e profissão. Como a maioria de profissionais da área é branca em um país cuja maioria da população é negra, torna-se cada vez mais urgente e necessário revisitar tanto as bases da psicologia acerca das relações raciais quanto o modo como essas relações se dão no cotidiano, com vistas a construir caminhos para pensar teoria e prática comprometidas com a igualdade racial. Nesse sentido, tecem-se considerações sobre as narrativas teóricas acerca das relações raciais no campo científico brasileiro, destacando o lugar da psicologia nesse percurso. Em seguida, discutem-se as relações entre as perspectivas da realidade social e das produções de saberes nesse campo. Ainda mais especificamente no campo da psicologia, evidenciam-se os paradigmas que orientaram os estudos sobre as relações raciais na área e, por fim, aponta-se um caminho possível para a construção de uma ciência psicológica compromissada com a igualdade racial.(AU)


This paper presents a historical overview of the theoretical narratives constructed by white Brazilian intellectual elites about race relations within psychology and its the effects on the development of Psychology as a science and a profession. As psychology professionals are white, whereas the majority of the population is black, it is increasingly urgent and necessary to revisit the foundations of psychology on everyday life racial relations, towards a theory and practice committed to racial equality. The text presents considerations on the theoretical narratives about race relations in the Brazilian scientific field, highlighting the role played by psychology. It then discusses the relations between social reality and knowledge production in this field. Regarding psychology specifically, it highlights the paradigms that guided studies on race relations in the field and proposes a possible way to develop a psychological science committed to racial equality.(AU)


Este trabajo realiza un recorrido histórico sobre las narrativas teóricas construidas por las élites intelectuales brasileñas blancas sobre las relaciones raciales en el campo de la Psicología, y los efectos de este proceso en el desarrollo de la psicología como ciencia y profesión. Como la mayoría de los profesionales en el área son blancos en un país donde la mayoría de la población es negra, es cada vez más urgente y necesario revisar los fundamentos de la psicología sobre las relaciones raciales, y cómo son estas relaciones en la vida cotidiana, para que podamos construir teoría y práctica comprometidas con la igualdad racial. Primero, se reflexionará sobre las narrativas teóricas de las relaciones raciales en este campo científico brasileño, destacando el lugar de la psicología en este camino. Luego, se discutirán las relaciones entre las perspectivas sobre la realidad social y la producción de conocimiento en este campo. Aún más específicamente en el campo de la psicología, se resaltarán los paradigmas que guiaron los estudios sobre las relaciones raciales en el área y, finalmente, se señalará un posible camino en la construcción de una ciencia psicológica comprometida con la igualdad racial.(AU)


Subject(s)
Humans , Male , Female , Psychology , Race Relations , Personal Narrative , Perceptual Distortion , Politics , Poverty , Prejudice , Psychoanalysis , Psychology, Social , Public Policy , Self Concept , Social Behavior , Social Class , Social Isolation , Social Justice , Social Perception , Social Problems , Social Sciences , Socialization , Socioeconomic Factors , Sociology , Stereotyping , Thinking , Unemployment , Universities , Genetic Variation , Violence , Black or African American , Body Image , Brazil , Career Mobility , Mental Health , Public Health , Women's Health , Cognitive Dissonance , Colonialism , Concentration Camps , Conflict, Psychological , Cultural Diversity , Feminism , Disaster Vulnerability , Democracy , Dehumanization , Commodification , Behavioral Research , Genetic Determinism , Education, Public Health Professional , Racial Groups , Black People , Discrimination, Psychological , Education , Ego , Health Status Disparities , Esthetics , Racism , Human Migration , Enslavement , Literacy , Social Segregation , Desegregation , Political Activism , Academic Success , Academic Failure , Ethnic Inequality , Social Privilege , Frustration , Respect , Psychological Distress , Public Nondiscrimination Policies , Right to Work , Empowerment , Social Comparison , Social Representation , Environmental Justice , Intersectional Framework , Ethnic and Racial Minorities , Citizenship , Diversity, Equity, Inclusion , Socioeconomic Disparities in Health , Residential Segregation , Antiracism , Guilt , Hierarchy, Social , Human Development , Human Rights , Individuation , Intelligence , Interpersonal Relations , Interprofessional Relations , Jurisprudence , Anger , Morale
3.
Psicol. ciênc. prof ; 43: e244422, 2023. tab, graf
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1431118

ABSTRACT

Funções executivas (FE) referem-se ao conjunto de habilidades que, de forma integrada, coordenam o comportamento e a cognição. Assim, o comprometimento no desenvolvimento das FE está ligado a vários desfechos negativos ao longo da vida. Portanto, a avaliação dessas habilidades na infância é essencial para identificar e prevenir prejuízos na vida adulta. Este estudo teve como objetivo investigar evidências de validade do Teste Informatizado para Avaliação das Funções Executivas (Tafe) pelo critério de idade e pelo padrão de correlação entre medidas do TAFE e outras medidas de FE. Para isso, foi utilizada uma amostra de 51 crianças, entre 4 e 10 anos de idade, matriculadas em uma escola privada na cidade de Goiânia (GO), da pré-escola ao 4º ano do ensino fundamental. Como instrumentos, foram utilizados, além do Tafe, as tarefas de Bloco de Corsi, Teste de Trilhas A e B, Teste de Trilhas Pré-Escolares, Teste de Stroop Pré-Escolares e Subteste Dígitos da Escala Wechsler de Inteligência. Foram conduzidas análises estatísticas Kruskal Wallis para verificar a evidência de validade por relação com idade e análises de correlação não paramétrica de Spearman para avaliar as evidências de validade convergente. O instrumento investigado mostrou-se efetivo para discriminar entre as diferentes faixas etárias, assim, sensível ao desenvolvimento das FE. Os resultados obtidos no Tafe correlacionaram-se aos obtidos em outros testes que também avaliaram FE, mostrando claros padrões de convergência. Logo, as análises dos resultados fornecem evidências de validade ao Tafe, derivadas a partir de diferentes estratégias de investigação.(AU)


Executive functions (EF) refer to the set of skills that, in an integrated way, coordinate behavior and cognition. Thus, the commitment in developing EF is linked to several negative outcomes throughout life. Therefore, the assessment of these abilities in childhood is essential to identify and prevent possible harm in adult life. This study aimed to investigate evidences of validity of the Computerized Test for Evaluation of Executive Functions (TAFE) by the age criterion and by the pattern of correlation between TAFE measures and other EF measures. To this end, a sample of 51 children, between 4 and 10 years old, enrolled in a private school in the municipality of Goiânia (GO), from preschool to the 4th year of elementary school, was used. As instruments, in addition to TAFE, the tasks of Corsi Block, Trails Test A and B, Preschool Trails Test, Preschool Stroop Test and the Digits Subtest of the Wechsler Intelligence Scale were used. Kruskal Wallis statistical analyzes were conducted to verify the evidence of validity by age criteria and Spearman's nonparametric correlation analysis to assess evidence of convergent validation. The instrument investigated was effective to discriminate between different age groups, thus being sensitive to the development of EF. The results obtained in TAFE were correlated with those obtained in other tests that also assess FE, showing patterns of convergence. Therefore, the analysis of the results provides validation evidence to TAFE, derived from different investigation methods.(AU)


Las funciones ejecutivas (FE) se refieren al conjunto de habilidades que coordinan la conducta y la cognición. Así, el deterioro en el desarrollo de FE está relacionado con varios resultados negativos durante la vida. Por tanto, la valoración de estas habilidades en la infancia es fundamental para identificar y prevenir posibles daños en la vida adulta. Este estudio tuvo como objetivo investigar la evidencia de validez de la Prueba Computarizada para Evaluación de Funciones Ejecutivas (Tafe) por el criterio de edad y convergencia entre las medidas Tafe y otras medidas de FE. Para ello, se utilizó una muestra de 51 niños, de entre 4 y 10 años de edad, matriculados en un colegio privado de Goiânia (Goiás, Brasil) desde la preescolar hasta 4.º de primaria. Como instrumentos, además del Tafe, se utilizaron las tareas de Bloque de Corsi, el Test de los senderos A y B, el Test de los Senderos Preescolares, el Test de Stroop Preescolar y la Subprueba de Dígitos de la Escala Wechsler de Inteligencia. Se realizaron análisis estadísticos de Kruskal Wallis para verificar la validez por criterios de edad y análisis de correlación no-paramétrica de Spearman para evaluar la evidencia de validez convergente. Tafe demostró ser efectivo para discriminar entre diferentes grupos de edad, así es sensible al desarrollo de FE. Los resultados en Tafe se correlacionaron con los obtenidos en otras pruebas de FE, lo que muestra claros patrones de convergencia. Por tanto, el análisis aporta evidencias de validez para Tafe, derivadas de diferentes estrategias de investigación.(AU)


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Cognition , Pliability , Inhibition, Psychological , Memory, Short-Term , Perception , Aptitude Tests , Play and Playthings , Play Therapy , Primary Health Care , Problem Solving , Psychological Phenomena , Psychological Tests , Psychology , Recreation , Schools , Auditory Perception , Social Support , Speech Perception , Task Performance and Analysis , Technology , Thinking , Wechsler Scales , Behavior , Behavioral Sciences , Neurosciences , Child , Child Care , Child, Preschool , Child Health , Statistics, Nonparametric , Neurobehavioral Manifestations , Behavioral Disciplines and Activities , Recognition, Psychology , Growth and Development , Discrimination, Psychological , Education , Planning , Cerebrum , Executive Function , Stroop Test , Metacognition , Wechsler Memory Scale , Memory and Learning Tests , Self-Management , Mentalization , Systematic Review , Multidimensional Scaling Analysis , Functional Status , Social Interaction , Imagination , Language Development , Language Development Disorders , Learning , Motor Activity , Neuropsychological Tests , Neuropsychology
4.
Psicol. ciênc. prof ; 43: e248738, 2023. tab, graf
Article in Portuguese | LILACS, INDEXPSI | ID: biblio-1431135

ABSTRACT

A recuperação de vítimas de queimaduras é longa e dolorosa e afeta diversas esferas da vida do paciente. A resiliência, que se refere à capacidade humana de enfrentar e se adaptar a eventos adversos, exerce grande importância no processo de recuperação da queimadura. Logo, este trabalho objetiva avaliar a capacidade de resiliência de pacientes queimados, no momento da admissão e da alta hospitalar, em um hospital de emergência e urgência de Goiânia. Trata-se de um estudo descritivo, quantitativo e transversal que utiliza a Escala de Resiliência de Connor-Davidson (CD-RISC) como instrumento de mensuração. Na admissão hospitalar, a média da resiliência foi de 71,35, tendo sido observada uma relação significativa entre o fator Amparo da escala CD-RISC e a presença do(a) companheiro(a). O escore de resiliência encontrado nesta pesquisa é consistente com outros achados da literatura científica internacional e nacional referente à expressão da resiliência em vítimas de queimaduras e outros adoecimentos. A relação entre o fator Amparo e a presença de um(a) companheiro(a) enfatiza a importância da rede de apoio familiar na reabilitação do paciente queimado.(AU)


The recovery of burned patients is long and painful and impacts on different areas of people's lives. Resilience, which refers to the human capacity to face and adapt to adverse events, plays a major role in the process of recovery from burns. Therefore, the present study aims to assess the resilience of burned patients, on admission and hospital discharge, in an emergency and urgency hospital in Goiânia. This is a descriptive, quantitative and cross-sectional study that uses the Connor-Davidson Resilience Scale (CD RISC) as a measuring instrument. At hospital admission, the mean resilience was 71.35, with a significant association between the Support factor on the CD RISC scale and the presence of a partner. The resilience score found in the present study is consistent with other findings in the international and national scientific literature regarding the expression of resilience in victims of burns and other illnesses. The relationship between the Support factor and the presence of a partner emphasizes the importance of the family support network in the rehabilitation of the burned patient.(AU)


La recuperación de los pacientes quemados es larga y dolorosa e impacta en diferentes esferas de la vida de las personas. La resiliencia, que se refiere a la capacidad humana para enfrentar y adaptarse a eventos adversos, juega un papel importante en el proceso de recuperación de las quemaduras. Por tanto, el presente estudio tiene como objetivo evaluar la resiliencia de los pacientes quemados, en el momento del ingreso y el alta, en un hospital de emergencia y urgencia en Goiânia. Se trata de un estudio descriptivo, cuantitativo y transversal que utiliza la Escala de Resiliencia Connor-Davidson (CD RISC) como instrumento de medida. Al ingreso hospitalario, la resiliencia media fue de 71,35, con associación significativa entre el factor Amparo de la escala CD RISC y la presencia de pareja. El puntaje de resiliencia encontrado en el presente estudio es consistente con otros hallazgos en la literatura científica nacional e internacional sobre la expresión de resiliencia en víctimas de quemaduras y otras enfermedades. La relación entre el factor Amparo y la presencia de pareja enfatiza la importancia de la red de apoyo familiar en la rehabilitación del paciente quemado.(AU)


Subject(s)
Humans , Female , Adolescent , Adult , Young Adult , Social Support , Burns , Resilience, Psychological , Anxiety Disorders , Pain , Preceptorship , Prejudice , Psychological Phenomena , Psychology , Recovery Room , Rehabilitation Centers , Safety , Self Concept , Skin , Social Perception , Stress Disorders, Post-Traumatic , Suicide , General Surgery , Surgery, Plastic , Tissues , Baths , Wounds and Injuries , Behavior , Behavior and Behavior Mechanisms , Technical Cooperation , Unified Health System , Body Image , Traumatology , Burn Units , Burns, Chemical , Burns, Electric , Accidents, Home , Accidents, Occupational , Accidents, Traffic , Explosive Wastes , Inflammable Wastes , Mental Health , Morbidity , Cicatrix , Nursing , Panic Disorder , Employment, Supported , Statistics, Nonparametric , Human Body , Intuition , Wit and Humor , Hydrogels , Counseling , Critical Care , Disaster Vulnerability , Personal Autonomy , Death , Stress Disorders, Traumatic, Acute , Depression , Discrimination, Psychological , Education , Empathy , Humanization of Assistance , User Embracement , Ethics , Breakthrough Pain , Activation, Metabolic , Physical Appearance, Body , Trauma and Stressor Related Disorders , Psychological Trauma , Accidental Injuries , Psychological Distress , Social Comparison , Functional Status , Self-Compassion , Accident Prevention , Health Services Accessibility , Helping Behavior , Homicide , Amputation, Traumatic , Hospitalization , Individuality , Intensive Care Units , Interpersonal Relations , Life Change Events , Mental Disorders , Negativism , Nursing Assistants , Nursing Care
5.
Article in English | AIM | ID: biblio-1413619

ABSTRACT

Background: Community-based inclusive development (CBID) acknowledges society's critical role in supporting the active participation of persons with disabilities. However, research on how this approach relates to the context-sensitive socially situated barriers of disability stigma is underexplored. Objectives: This study aimed to understand the drivers and experiences of disability stigma in Ethiopia, from the perspective of persons with disabilities engaged in CBID programmes, and to establish how disability stigma acts as a barrier to participation. Methods: An inductive methodological approach guided the research design. Mixed methods were used including a narrative review of disabilities studies literature, 16 semi-structured interviews with persons with disabilities, and a quantitative survey of 970 persons with disabilities across three communities in Ethiopia. Results: Informed by theories of epistemic justice, this study identified specific indicators of meaningful participation and examined how these relate to experiences of disability stigma. The study found that the participation of adults with disabilities in society is restricted across different areas of life. Misconceptions about the causes of disability and social perceptions regarding the capacities of persons with disabilities are found to exacerbate stigma and act as a barrier to participation. Conclusion: Targeted efforts to challenge internalised norms and harmful beliefs within CBID approaches are required to address disadvantages arising from embedded disability stigma. Contribution: This study makes conceptual, empirical and practical contributions that advance insights into the relationship between disability stigma and participation in Ethiopia and the dimensions of epistemic justice relevant to understanding the nature and drivers of disability stigma.


Subject(s)
Humans , Male , Female , Social Isolation , Disabled Persons , Discrimination, Psychological , Social Stigma , Stereotyping , Attitude of Health Personnel , Community Participation
6.
Estud. psicol. (Natal) ; 27(1): 104-114, jan.-abr. 2022.
Article in Portuguese | LILACS | ID: biblio-1433815

ABSTRACT

Diante da multiplicação atual dos inimigos nacionais no Brasil, que atravessam as relações de gênero, sexualidade, raça e classe, neste texto abordamos um aspecto específico dessa guerra generalizada: a guerra contra os loucos. Com o objetivo de analisar o retorno recente do fortalecimento das arquiteturas de confinamento no campo da saúde mental, demarcando relações entre racionalidade e território, este artigo parte de um questionamento a respeito do espaço político dado ao louco e ao enlouquecimento, à diferença e à dor, à guerra aos loucos e à loucura na guerra. Como disparador, nos acompanhará principalmente a obra de Ignacio Martín-Baró e suas críticas ao psicologismo colonial, assim como à naturalização e à patologização de condições e efeitos do capitalismo. Podemos traçar instigantes paralelos da nossa experiência com os escritos de Martín-Baró, elaborando um lugar de resistência possível para a psicologia nesse campo de batalha.


In view of the current multiplication of national enemies in Brazil, which cross gender, sexuality, race and class relations, in this text we approach a specific aspect of this generalized war: the war against the mad. With the objective of analyzing the recent return of strengthening confinement architectures in the field of mental health, demarcating relations between rationality and territory, this article is triggered from a questioning about the political space given to the mad and the madness, to the difference and to the pain, to the war against the mad and to the madness in war. As a trigger, it will be shared the work of Ignacio Martín-Baró and his criticisms of colonial psychologism, as well as the naturalization and pathologization of conditions and effects of capitalism. We can draw instigating parallels from our experience with Martín-Baró's writings, elaborating a possible place of resistance for psychology in this battlefield.


En vista de la actual multiplicación de enemigos nacionales en Brasil, que atraviesan las relaciones de género, sexualidad, raza y clase, en este texto abordamos un aspecto específico de esta guerra generalizada: la guerra contra los locos. Con el objetivo de analizar el reciente regreso del fortalecimiento de las arquitecturas de confinamiento en el campo de la salud mental, demarcando relaciones entre racionalidad y territorio, este artículo parte de un cuestionamiento sobre el espacio político que se le da al loco y a la locura, a la diferencia y al dolor, a la guerra contra los locos y a la locura en la guerra. Como detonante, nos acompañará la obra de Ignacio Martín-Baró y sus críticas al psicologismo colonial, así como la naturalización y patologización de las condiciones y efectos del capitalismo. Podemos trazar paralelos estimulantes de nuestra experiencia con los escritos de Martín-Baró, creando un posible lugar de resistencia para la psicología en este campo de batalla.


Subject(s)
Humans , Psychology, Social , Mental Disorders , Discrimination, Psychological
7.
African Journal of Disability ; 11: 1-11, 2022. Figures
Article in English | AIM | ID: biblio-1397069

ABSTRACT

Disability, and everything it encompasses, presents major challenges to individuals, families and communities worldwide. Children with disabilities (CWD) are marginalised and excluded in most societies. Discrimination and prejudice towards CWD are compounded by poverty, lack of essential services and support and sometimes a hostile and inaccessible environment. Objectives: The study sought to examine the psychosocial challenges experienced by CWD in the Sekhukhune district of Limpopo province, South Africa. Based on the identified, articulated and expressed challenges, the study sought to recommend improvement of the existing Integrated National Disability Strategy (INDS) for greater responsiveness to the needs of CWD at both provincial and local levels. Method: The interpretivist qualitative mode of enquiry was the chosen methodology for this study. Phenomenology and descriptive research designs guided the study. Purposive sampling was employed, and data were collected from 36 participants using three triangulated methods: individual in-depth interviews, focus group discussions and key informant interviews. Thematic data analysis was used to analyze data. Results: The findings revealed that CWD in Sekhukhune experienced numerous challenges which affected their social functioning, development and general well-being. Aggravating factors included stigma, labelling and discrimination; disability-specific discrimination and bullying; exclusive education; sexual exploitation; lack of governmental support and poor implementation of disability-specific policies, amongst others. Conclusion: The provisions of the INDS to promote inclusion, integration, mainstreaming and equitable access to resources and services remained an ideal rather than a reality for CWD in Sekhukhune.


Subject(s)
Developmental Disabilities , Disabled Children , Discrimination, Psychological , Intellectual Disability , Prejudice , South Africa
8.
African Health Sciences ; 22(1): 252-262, March 2022. Tables
Article in English | AIM | ID: biblio-1400550

ABSTRACT

Background: Epilepsy is associated with stigma and negatively impacts the lives of people living with epilepsy (PLWE) and their immediate families. More understanding of the stigma and discrimination experienced by PLWE in sub-Saharan Africa is needed. Methods: In a cross-sectional, mixed methods study, forty- eight PLWE who met the study inclusion criteria were enrolled. In depth interviews and focus group discussions were conducted and were audiotaped and transcribed verbatim. Analysis was conducted using a thematic, constant comparative approach with an emphasis on dominant themes. Perceived stigma was measured using the Kilifi epilepsy stigma score. Associations between socio-demographic factors and Kilifi epilepsy stigma score were assessed. Results: The median age of the study participants was 25 years, with median age (IQR) of epilepsy onset of 12 (6-18) years. The prevalence of high-perceived stigma was 31.9% (15/48). Seizure frequency was associated with high levels of perceived stigma (p-value of 0.038). Psychological abuse, rejections at home, places of employment and schools, poor relationships and intimacy and unmet engagements in social activities were cited as the perceived stigmatizing aspects among PLWE. Conclusion: In this Ugandan sample perceived stigma remains unacceptably high and interventions to address it are urgently needed in our settings.


Subject(s)
Discrimination, Psychological , Epilepsy , Social Stigma , Anthropogenic Effects , Uganda
9.
Rev. bras. educ. méd ; 45(2): e097, 2021. tab, graf
Article in English | LILACS | ID: biblio-1279836

ABSTRACT

Abstract: Introduction: Mental disorders are accountable for the segregation of patients in many diverse cultures and historical moments worldwide. The evolution of neuroscience, technologies and advances in the psychosocial sphere have not been enough to change this paradigm. Many people still fear having social relations with someone with a psychiatric disorder, despite scientific progress and efforts to reduce prejudice in recent decades. Objective: The aim of this study was to assess the training in mental health during the undergraduate course offered to residents in Internal Medicine and analyze the feelings, perceptions, and stigmas of these physicians regarding the care offered to patients with mental disorders. Method: This study has a qualitative, quantitative approach and descriptive, cross-sectional design. Thirty-two residents in Internal Medicine participated and, for comparison, the questionnaires were also answered by 8 residents in Psychiatry. Two instruments were applied: one for the characterization of the participants' sociodemographic profile and the attribution questionnaire (AQ-26B). Qualitative data were obtained through a focus group with 14 residents and the content analysis was used for categorization. The most frequent categories were illustrated with Pareto charts. Results: The results demonstrated that residents in internal medicine showed higher indexes of stigma regarding aspects such as fear and intolerance. It was also possible to infer gaps related to training in mental health, low perception of care responsibility, in addition to the difficulty in legitimizing complaints and showing negative feelings. Conclusion: One can conclude the need for educational interventions that promote the decrease of the stigma and the search for training regarding comprehensive and empathic care for patients with mental disorders.


Resumo: Introdução: Os transtornos mentais são responsáveis pela segregação de pacientes em diversas culturas e momentos históricos globalmente. A evolução das neurociências, tecnologias e avanços na esfera psicossocial não têm sido suficientes para mudar este paradigma. Muitas pessoas ainda temem ter relações sociais com alguém com transtorno psiquiátrico, apesar dos avanços científicos e dos esforços para reduzir o preconceito nas últimas décadas. Objetivo: Este estudo teve como objetivos avaliar a formação em saúde mental na graduação oferecida a médicos residentes de clínica médica e analisar os sentimentos, as percepções e os estigmas deles ante a assistência a pacientes com transtornos mentais. Método: Trata-se de um estudo com abordagens qualitativas e quantitativas, de natureza descritiva e transversal. Participaram 32 residentes de clínica médica, e, para comparação, os questionários foram respondidos por oito residentes de psiquiatria. Aplicaram-se dois instrumentos: um para a caracterização do perfil sociodemográfico dos participantes e o questionário de atribuição (AQ-26B). Os dados qualitativos foram obtidos por meio de grupo focal com 14 residentes, e empregou-se a análise de conteúdo para categorização. As categorias de maior frequência foram ilustradas com diagramas de Pareto. Resultado: Como os residentes de clínica demonstraram maiores índices de estigma em aspectos como medo e intolerância, intuiu-se que há lacunas na formação em saúde mental, baixa percepção de responsabilidade do cuidado, além de dificuldade em legitimar as queixas e exibir sentimentos negativos. Conclusão: Concluiu-se pela necessidade de intervenções educacionais que fomentem a diminuição do estigma e a busca de capacitação para o cuidado integral e empático de pessoas com transtornos mentais.


Subject(s)
Humans , Mental Health/education , Social Stigma , Internship and Residency , Mental Disorders , Socioeconomic Factors , Students, Medical/psychology , Medical Care Statistics , Cross-Sectional Studies , Surveys and Questionnaires , Focus Groups , Discrimination, Psychological , Education, Medical/methods
10.
Rev. colomb. psiquiatr ; 49(3): 216-219, jul.-set. 2020.
Article in Spanish | LILACS, COLNAL | ID: biblio-1149831

ABSTRACT

RESUMEN Don Quijote de la Mancha, el pintoresco personaje creado por Miguel de Cervantes Saavedra en su obra inmortal El Ingenioso Hidalgo Don Quijote de la Mancha, presenta varias condiciones neuropsiquiátricas que incluyen tremor, trastornos del sueño, síntomas neuropsiquiátricos, síncope, trastornos de la percepción y traumatismo craneoencefálico. A lo largo de la obra, se presentan episodios en los que se hacen evidentes los diferentes trastornos mencionados. El artículo hace un recuento de ellos a través de la novela y un análisis a la luz de los conocimientos actuales sobre dichas condiciones.


ABSTRACT Don Quixote of La Mancha, the picturesque character created by Miguel de Cervantes Saavedra in his immortal book The Ingenious Nobleman Sir Quixote of La Mancha, presents several neuropsychiatric conditions, including tremor, sleep disturbances, neuropsychiatric symptoms, syncope, perception disorders and traumatic brain injury. Throughout the masterpiece, there are episodes where the aforementioned disorders are evident. This paper makes a list of them and analyses them in the light of the current knowledge of those conditions.


Subject(s)
Humans , Perceptual Disorders , Neuropsychiatry , Sleep , Sleep Wake Disorders , Syncope , Discrimination, Psychological
11.
Annals of Laboratory Medicine ; : 131-141, 2020.
Article in English | WPRIM | ID: wpr-762474

ABSTRACT

BACKGROUND: The ability of urinary biomarkers to complement established clinical risk prediction models for postoperative adverse kidney events is unclear. We assessed the effect of urinary biomarkers linked to suspected pathogenesis of cardiac surgery-induced acute kidney injury (AKI) on the performance of the Cleveland Score, a risk assessment model for postoperative adverse kidney events. METHODS: This pilot study included 100 patients who underwent open-heart surgery. We determined improvements to the Cleveland Score when adding urinary biomarkers measured using clinical laboratory platforms (neutrophil gelatinase-associated lipocalin [NGAL], interleukin-6) and those in the preclinical stage (hepcidin-25, midkine, alpha-1 microglobulin), all sampled immediately post-surgery. The primary endpoint was major adverse kidney events (MAKE), and the secondary endpoint was AKI. We performed ROC curve analysis, assessed baseline model performance (odds ratios [OR], 95% CI), and carried out statistical reclassification analyses to assess model improvement. RESULTS: NGAL (OR [95% CI] per 20 concentration-units wherever applicable): (1.07 [1.01–1.14]), Interleukin-6 (1.51 [1.01–2.26]), midkine (1.01 [1.00–1.02]), 1-hepcidin-25 (1.08 [1.00–1.17]), and NGAL/hepcidin-ratio (2.91 [1.30–6.49]) were independent predictors of MAKE and AKI (1.38 [1.03–1.85], 1.08 [1.01–1.15], 1.01 [1.00–1.02], 1.09 [1.01–1.18], and 3.45 [1.54–7.72]). Category-free net reclassification improvement identified interleukin-6 as a model-improving biomarker for MAKE and NGAL for AKI. However, only NGAL/hepcidin-25 improved model performance for event- and event-free patients for MAKE and AKI. CONCLUSIONS: NGAL and interleukin-6 measured immediately post cardiac surgery may complement the Cleveland Score. The combination of biomarkers with hepcidin-25 may further improve diagnostic discrimination.


Subject(s)
Humans , Acute Kidney Injury , Biomarkers , Complement System Proteins , Discrimination, Psychological , Hepcidins , Interleukin-6 , Kidney , Lipocalins , Pilot Projects , Risk Assessment , ROC Curve , Thoracic Surgery
12.
Yonsei Medical Journal ; : 154-160, 2020.
Article in English | WPRIM | ID: wpr-782196

ABSTRACT

0.05). The area under the receiver operating characteristics curve (AUC) was 0.922 [95% confidence interval (CI) 0.89–0.95]. In external validation, the discrimination was good, with an AUC value of 0.833 (95% CI 0.70–0.92) for this model. Nomogram calibration plots indicated good agreement between the predicted and observed outcomes, exhibiting close approximation between the predicted and observed probability.CONCLUSION: We constructed a scoring model for predicting massive transfusion during cesarean section in women with placenta previa. This model may help in determining the need to prepare an appropriate amount of blood products and the optimal timing of blood transfusion.


Subject(s)
Female , Humans , Pregnancy , Area Under Curve , Blood Transfusion , Calibration , Cesarean Section , Cohort Studies , Discrimination, Psychological , Early Intervention, Educational , Erythrocytes , Logistic Models , Maternal Age , Nomograms , Placenta Previa , Placenta , Placentation , Postpartum Hemorrhage , ROC Curve , Ultrasonography
13.
The Korean Journal of Physiology and Pharmacology ; : 27-37, 2020.
Article in English | WPRIM | ID: wpr-787141

ABSTRACT

Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but it has also been shown to exhibit strong antioxidative, anti-inflammatory, and neuroprotective effects. Here, we sought to investigate the effects of CAR on inflammation in the hippocampus and prefrontal cortex, as well as the molecular mechanisms underlying these effects. In our study, lipopolysaccharide was injected into the lateral ventricle of rats to induce memory impairment and neuroinflammation. Daily administration of CAR (25, 50, and 100 mg/kg) for 21 days improved recognition, discrimination, and memory impairments relative to untreated controls. CAR administration significantly attenuated expression of several inflammatory factors in the brain, including interleukin-1β, tumor necrosis factor-α, and cyclooxygenase-2. In addition, CAR significantly increased expression of brain-derived neurotrophic factor (BDNF) mRNA, and decreased expression of Toll-like receptor 4 (TLR4) mRNA. Taken together, these results show that CAR can improve memory impairment caused by neuroinflammation. This cognitive enhancement is due to the anti-inflammatory effects of CAR medicated by its regulation of BDNF and TLR4. Thus, CAR has significant potential as an inhibitor of memory degeneration in neurodegenerative diseases.


Subject(s)
Animals , Rats , Brain , Brain-Derived Neurotrophic Factor , Cyclooxygenase 2 , Cytokines , Discrimination, Psychological , Food Additives , Hippocampus , Inflammation , Lateral Ventricles , Lipopolysaccharides , Memory , Necrosis , Neurodegenerative Diseases , Neuroprotective Agents , Phenol , Prefrontal Cortex , RNA, Messenger , Toll-Like Receptor 4
14.
Acta colomb. psicol ; 22(1): 52-60, ene.-jun. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-989075

ABSTRACT

Resumen Seis grupos de estudiantes de preparatoria se expusieron a una tarea de igualación de la muestra de segundo orden y a pruebas de generalización con estímulos familiares y no familiares, así como con una nueva relación de igualación. Para dos grupos, las respuestas de igualación correctas e incorrectas produjeron la retroalimentación correspondiente de acuerdo con un programa continuo y uno intermitente, respectivamente. Las respuestas correctas produjeron retroalimentación y las respuestas incorrectas produjeron pantallas en blanco y viceversa para otros dos grupos, respectivamente. Dos grupos adicionales estuvieron expuestos a combinaciones similares de retroalimentación y pantallas en blanco, pero se instruyó a los participantes sobre el "significado" de las pantallas antes del entrenamiento. Se observó igualación de la muestra generalizada extra-relacional con estímulos familiares o no familiares solo después de las condiciones de entrenamiento en las que se programó retroalimentación intermitente Correcto-Incorrecto, así como cuando las respuestas de igualación incorrectas produjeron pantallas en blanco y las respuestas correctas produjeron la retroalimentación correspondiente. Las instrucciones sobre el significado de las pantallas en blanco produjeron ejecuciones generalizadas ligeramente superiores a las observadas después de la retroalimentación continua Correcto-Incorrecto, las cuales a su vez fueron similares a las ejecuciones observadas después de la condición Correcto-Pantalla en blanco, sin instrucción. Los resultados confirman una tendencia inicial a tratar las pantallas en blanco como retroalimentación para respuestas correctas y sugieren un proceso común de "desligamiento" entre la retroalimentación intermitente y la retroalimentación Incorrecto-Pantalla en blanco.


Resumo Seis grupos de estudantes de vestibular foram expostos a uma tarefa de igualação da amostra de segunda ordem e a testes de generalização com estímulos familiares e não familiares, bem como a uma nova relação de igualação. Para dois grupos, as respostas de igualação corretas e incorretas produziram a retroalimentação correspondente de acordo com um programa contínuo e um intermitente, respectivamente, em que as respostas corretas produziram retroalimentação e as incorretas, ecrãs brancos - e vice-versa para outros dois grupos. Dois grupos adicionais estiveram expostos a combinações semelhantes de retroalimentação e ecrãs brancos, mas foi instruído aos participantes o "significado" das telas antes do treinamento. Foi observada igualação da amostra generalizada extrarrelacional com estímulos familiares e não familiares somente depois das condições de treinamento nas quais foi programada a retroalimentação intermitente Correto-incorreto, bem como quando as respostas de igualação incorretas produziram ecrãs brancos, e quando as respostas corretas produziram a retroalimentação correspondente. As instruções sobre o significado dos ecrãs brancos produziram execuções generalizadas levemente superiores às observadas após a retroalimentação contínua Correto-incorreto, as quais, por sua vez, foram similares às execuções observadas depois da condição Correto-ecrã branco, sem instrução. Os resultados confirmam uma tendência inicial a tratar os ecrãs brancos como retroalimentação para respostas corretas e sugerem um processo comum de "desligamento" entre a retroalimentação intermitente e a retroalimentação Incorreto-ecrã branco.


Abstract Six groups of high-school students were exposed to a second-order matching-to-sample task and generalization tests trials using familiar and unfamiliar stimuli as well as a new matching relation. For two groups correct and incorrect matching responses produced the corresponding feedback according to continuous and intermittent schedules, respectively. Correct responses produced feedback and incorrect responses produced blanks and vice versa for other two groups, respectively. Two additional groups were exposed to similar feedback-blanks combinations but participants were instructed about the "meaning" of blanks before training. Extra-relational generalized matching-to-sample performance with either familiar or unfamiliar stimuli was observed after training conditions in which intermittent right-wrong feedback was scheduled, as well as when incorrect matching responses produced blanks and correct responses produced the corresponding feedback. Instructions about the meaning of blanks produced generalized performances slightly higher to those observed after continuous right-wrong feedback, which in turn were similar to performances observed after the uninstructed right-blank feedback combination condition. Results confirm an initial tendency to treat blanks as if they mean right and suggest a common "detachment" processes between intermittent feedback and the wrong-blanks feedback combination.


Subject(s)
Humans , Male , Female , Adolescent , Discrimination, Psychological , Program for Incentives and Benefits , Family Relations
15.
Rev. bras. epidemiol ; 22(supl.1): e190003, 2019. tab, graf
Article in English | LILACS | ID: biblio-1042212

ABSTRACT

ABSTRACT Introduction: Discrimination based on sexual orientation can influence vulnerability to HIV, increasing exposure to risky sexual behavior among men who have sex with men (MSM). Objectives: To analyze data using latent class analysis (LCA) to identify groups of individuals with specific patterns of discrimination based on sexual orientation (DSO). Methods: Cross-sectional study using respondent-driven sampling in 12 Brazilian cities in 2016. LCA was used to characterize discrimination among MSM based on 13 variables in the survey questionnaire. The proportions of men reporting DSO and other variables of interest were estimated using Gile's Successive Sampling estimator. Results: Most MSM were young, single, had a religion, had a high school or college degree, black or brown skin color, and socioeconomic status classified as average. More than half of the participants reported that they had been discriminated against during the last 12 months due to their sexual orientation (65%), more than a third said they had felt afraid of walking in public places during the past 12 months, and about one-fifth of participants reported having been victims of physical or sexual assault due to DSO. DSO was classified into four latent classes: "very high", "high", "moderate" and "low", with estimates of 2.2%, 16.4%, 35.1%, and 46.19%, respectively. Conclusion: We observed a high proportion of discrimination against MSM in this study. The use of LCA differentiated parsimoniously classes of discrimination.


RESUMO Introdução: A discriminação por orientação sexual (DPOS) pode influenciar a vulnerabilidade ao HIV aumentando a exposição a comportamentos sexuais de risco entre homens que fazem sexo com homens (HSH). Objetivos: Examinar dados utilizando a análise de classes latentes (ACL) para identificar grupos de indivíduos com padrões específicos de DPOS. Métodos: Estudo transversal com entrevistados recrutados pelo processo amostral respondent driven sampling em 12 cidades brasileiras em 2016. A ACL foi usada para caracterizar o DPOS entre HSH com base em 13 variáveis do bloco de discriminação do questionário da pesquisa. As proporções de DPOS e das variáveis de interesse, bem como seus intervalos de confiança (95%) foram ponderados usando o estimador de Gile. Resultados: A maioria era de jovens, solteiros, com alguma religião, escolaridade média ou superior, cor da pele preta ou parda e com nível socioeconômico médio. Mais da metade referiu ter sido discriminado nos últimos 12 meses por sua orientação sexual (65%), mais de um terço referiu ter tido medo de andar em lugares públicos nos últimos 12 meses e em torno de um quinto dos participantes reportaram ter sofrido agressão física ou sexual na vida. A DPOS foi classificada em 4 classes latentes, "muito alta", "alta", "média" e "baixa", com estimativas de 2,2%, 16,4%, 35,1% e 46,19%, respectivamente. Conclusão: Observou-se alta proporção de discriminação entre os HSH participantes deste estudo. A utilização da ACL discriminou de maneira parcimoniosa as classes de DPOS.


Subject(s)
Humans , Male , Adult , Homosexuality, Male/statistics & numerical data , Sexism/statistics & numerical data , Socioeconomic Factors , Brazil/epidemiology , Cross-Sectional Studies , Homosexuality, Male/ethnology , Discrimination, Psychological , Self Report , Sexism/ethnology , Latent Class Analysis
16.
urol. colomb. (Bogotá. En línea) ; 28(4): 303-306, 2019. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1402672

ABSTRACT

Introducción Los cuestionarios clínicos para los síntomas urinarios se diseñaron para objetivar los síntomas urinarios y de esa forma evitar estudios invasivos y costosos, con la división entre síntomas urinarios de vaciado y llenado, sin embargo, los pacientes presentan síntomas que hacen difícil el discernimiento entre obstrucción infravesical, detrusor hipocontractil o incluso detrusor hiperactivo. Determinar la correlación entre la uroflujometría y la severidad de los síntomas usando el IPSS (International Prostate Symptom Score) en pacientes síntomas urinarios, comparados con urodinamia y determinar su correlación con el diagnostico de obstrucción infravesical, detrusor hipocontráctil o detrusor hipocontráctil Métodos Estudio retrospectivo en el cual se recolectaron 27 hombres que consultaron por síntomas urinarios de vaciado y asistieron al Hospital Universitario de la Samaritana en Bogotá, Colombia entre abril del 2016 y abril del 2017. El IPSS se realizó a todos los pacientes con el cuestionario autoadministrado. Adicionalmente se realizó uroflujometría y urodinamia con el equipo de urodinámia Medical Measurement System SN077116. Resultados La edad promedio fue 67,26 años (37­86), IPSS leve del 22%, moderado 59% y severo 19%, con patrones de uroflujometricos campana 26%, meseta 41% intermitente 33%, el 37% presentaron un Qmax menor del 10%, el cual se consideró obstructivo y una PdetQmax menor de 40, en un 37%, lo cual es congruente con los resultados de la uroflujometria, además de relacionarse con residuo postmiccional elevado. Conclusión Existe una correlación entre el IPSS y el Qmax, comparado con patrones urodinámicos, la utilización de los índices como métodos no invasivos para el ahorro de costos si es comparable con hallazgos urodinámicos. Sin embargo, existe un porcentaje no despreciable de pacientes con Qmax menor de 10 que no corresponden a obstrucción infravesical. Es necesario tener en cuenta que hasta el 23% de los pacientes pueden presentar IPSS moderado o severo sin que el origen sea obstructivo.


Introduction Clinical questionnaires for urinary symptoms were designed to perform an objective evaluation of urinary symptoms and thus avoid invasive and expensive studies. However, patients present symptoms that make difficult the discernment between infravesical obstruction and hypocontractile detrusor. The aim of this study is to determine the correlation between uroflowmetry and symptom severity using the IPSS (International Prostate Symptom Score) in patients with urinary symptoms, compared with urodynamics and to determine its correlation with the diagnosis of infra-vesical obstruction or hypocontractile detrusor. Methods Observational retrospective study in which the clinical records of the patients who consulted for urinary emptying symptoms at La Samaritana University Hospital in Bogotá, Colombia, between April 2016 and April 2017 were reviewed. The IPSS was performed in all patients. Additionally, uroflowmetry and urodynamics were documented with the Medical Measurement System SN077116. Results A total of 27 patients were included in the study. The average age was 67.26 years. The mild IPSS was found in 22% of the patients, moderate 59% and severe 19%. Patterns were identified in uroflowmetry with bell curves in 26% of patients, plateau 41% and intermittent in 33%. 37% of the patients had a Qmax lower than 10 mL/s which was considered obstructive and a PdetQmax less than 40 cm H2O in 37%, which is consistent with the results of uroflowmetry, in addition to being related to high postvoid residual volume. Conclusion There is a correlation between IPSS and Qmax associated with urodynamic patterns. The use of indices as non-invasive methods to reduce costs is comparable with the urodynamic findings; however, there is a non-negligible percentage of patients with Qmax less than 10 mL/s who do not correspond to infravesical obstruction. It is necessary to take into account that up to 23% of patients can have moderate or severe IPSS without the origin of the symptoms being obstructive.


Subject(s)
Humans , Male , Aged , Prostate , Urodynamics , Surveys and Questionnaires , Residual Volume , Retrospective Studies , Discrimination, Psychological , Equipment and Supplies , Urinary Bladder, Overactive
17.
Journal of Korean Critical Care Nursing ; (3): 35-49, 2019.
Article in Korean | WPRIM | ID: wpr-788178

ABSTRACT

PURPOSE: This study aimed to propose a common scope of practice (SOP) for 13 specialties of Advanced Practice Nurses (APNs) in Korea.METHODS: The first draft of a common SOP was extracted from domestic and international laws with a literature review by 17 experts from the Korean Association of Advanced Practice Nurses (KAAPN). Then, the common SOP was finalized after comparing the activities of APNs in clinical settings.RESULTS: A total of 70 duties were identified and six categories were suggested for the common SOP. The SOP proposed by the KAAPN featured the following: 1) identification of and discrimination between health problems; 2) prescription and implementation of diagnostic tests; 3) treatment of injuries and diseases while implementing measures to prevent exacerbation; 4) prescription of medicinal products in line with 1) to 3); 5) referral and consultation; and 6) education and counseling. It was then confirmed that the proposed six categories in the common SOP reflected all the duties performed by APNs in clinical practice, including all 40 activities.CONCLUSION: The results of this study can be used as evidence for the legalization of a common SOP for APNs. Given the increasing multidisciplinary team approach adopted in Korean hospitals, it may be desirable to establish a broader SOP to reflect the diverse duties of APNs.


Subject(s)
Counseling , Diagnostic Tests, Routine , Discrimination, Psychological , Education , International Law , Korea , Prescriptions , Professional Practice , Referral and Consultation
18.
Yonsei Medical Journal ; : 619-625, 2019.
Article in English | WPRIM | ID: wpr-762099

ABSTRACT

PURPOSE: To evaluate predictors of severe or moderate coronary artery disease (CAD) in individuals with zero or very low (<10) coronary artery calcium (CAC) scores. MATERIALS AND METHODS: The 1175 asymptomatic persons with zero or very low (<10) CAC scores were analyzed for CAD stenosis using coronary computed tomography angiography. Moderate and severe CADs were defined as having more than 50% and more than 70% stenosis in any of the major coronary arteries, respectively. Age, gender, body mass index, hypertension, type II diabetes, dyslipidemia, lipid profile, creatinine, and smoking status were evaluated as predictors for moderate and severe CAD. RESULTS: In the study population, moderate and severe CADs were found in 7.5% and 3.3%, respectively. Among evaluated risk factors, age [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02−1.07, p<0.001], current smoking status (OR 3.12, 95% CI 1.82−5.34, p<0.001), and CAC 1−9 (OR 1.80, 95% CI 1.08−3.00, p=0.024) were significantly associated with moderate CAD. Meanwhile, age (OR 1.05, 95% CI 1.02−1.08, p=0.003), low high density lipoprotein (HDL) (OR 0.96, 95% CI 0.93−0.99, p=0.003), and current smoking status (OR 2.34, 95% CI 1.14−5.30, p=0.022) were found to be significantly associated with severe CAD. Improvement of discrimination power for predicting severe CAD was observed when smoking and HDL cholesterol were serially added into the age model. CONCLUSION: Smoking showed significant correlations with moderate or severe CAD, and low HDL cholesterol also proved to be a predictor of severe CAD in asymptomatic individuals with extremely low CAC scores.


Subject(s)
Humans , Angiography , Asymptomatic Diseases , Body Mass Index , Calcium , Cholesterol, HDL , Constriction, Pathologic , Coronary Artery Disease , Coronary Vessels , Creatinine , Discrimination, Psychological , Dyslipidemias , Hypertension , Lipoproteins , Risk Factors , Smoke , Smoking
19.
Yonsei Medical Journal ; : 1005-1012, 2019.
Article in English | WPRIM | ID: wpr-762060

ABSTRACT

PURPOSE: Identification of lymph node (LN) metastasis in non-small cell lung cancer (NSCLC) is critical for disease staging and selection of therapeutic modalities. Sometimes it is not possible to obtain LN core tissue by endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA), resulting in low diagnostic yield. MATERIALS AND METHODS: In this study, 138 specimens were collected from 108 patients who underwent EBUS-TBNA under the suspicion of LN metastasis of NSCLC. Diagnostic yields of anti-CD45 and anti-methionyl-tRNA synthetase (MRS), immunofluorescent (IF) staining on cytology specimens were compared with those of conventional cytology and positron emission tomography-computed tomography (PET-CT). RESULTS: MRS was strongly expressed in NSCLC cells metastasized to LNs, but weakly expressed in cells at the periphery of the LN germinal center. The majority of cells were CD20 positive, although a few cells were either CD3 or CD14 positive, indicating that CD45 staining is required for discrimination of non-malignant LN constituent cells from NSCLC cells. When the diagnostic efficacy of MRS/CD45 IF staining was evaluated using 138 LN cellular aspirates from 108 patients through EBUS-TBNA, the sensitivity was 76.7% and specificity was 90.8%, whereas those of conventional cytology test were 71.8% and 100.0%, respectively. Combining the results of conventional cytology testing and those of PET-CT showed a sensitivity and specificity of 71.6% and 100%, and the addition of MRS/CD45 dual IF data to this combination increased sensitivity and specificity to 85.1% and 97.8%, respectively. CONCLUSION: MRS/CD45 dual IF staining showed good diagnostic performance and may be a good tool complementing conventional cytology test for determining LN metastasis of NSCLC.


Subject(s)
Humans , Amino Acyl-tRNA Synthetases , Carcinoma, Non-Small-Cell Lung , Complement System Proteins , Discrimination, Psychological , Electrons , Germinal Center , Ligases , Lymph Nodes , Methionine-tRNA Ligase , Needles , Neoplasm Metastasis , Sensitivity and Specificity
20.
Yonsei Medical Journal ; : 1028-1035, 2019.
Article in English | WPRIM | ID: wpr-762057

ABSTRACT

PURPOSE: To validate and update a nomogram for predicting ductal carcinoma in situ (DCIS) upstaging in preoperative biopsy. MATERIALS AND METHODS: Medical records of 444 preoperative DCIS patients were evaluated and used to validate a previous version of the Severance nomogram for predicting DCIS upstaging in preoperative biopsy. Patients were divided into two groups according to the final postoperative pathology. Univariate and multivariate analyses with the chi-square test, Student's t-test, and binary logistic regression method identified new significant variables. The updated nomogram was evaluated with the C-index and Hosmer—Lemeshow goodness of fit test. RESULTS: The area under a receiver operating characteristic curve for comparison with the previous nomogram was 0.48. In postoperative pathology, the pure DCIS and invasive cancer groups comprised 345 and 99 cases, respectively. Approximately 22.3% of patients preoperatively diagnosed with DCIS were upstaged to invasive cancer. Significant variables in the univariate analysis were operation type, human epidermal growth factor receptor 2 overexpression, comedo necrosis, sonographic mass, mammographic mass, preoperative biopsy method, and suspicious microinvasion in preoperative biopsy. In multivariate analysis, operation type, sonographic mass, mammographic mass, and suspicious microinvasion were risk factors for upstaging. The updated model with these variables showed moderate discrimination and was appropriate in the calibration test. CONCLUSION: The previous nomogram did not effectively discriminate upstaging of preoperative DCIS in an independent cohort. An updated version of the nomogram appears to provide more accurate information for predicting preoperative DCIS upstaging.


Subject(s)
Humans , Biopsy , Breast Neoplasms , Breast , Calibration , Carcinoma, Ductal , Carcinoma, Intraductal, Noninfiltrating , Cohort Studies , Discrimination, Psychological , Logistic Models , Medical Records , Methods , Multivariate Analysis , Necrosis , Nomograms , Pathology , ErbB Receptors , Risk Factors , ROC Curve , Ultrasonography
SELECTION OF CITATIONS
SEARCH DETAIL