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1.
In. Soeiro, Alexandre de Matos; Leal, Tatiana de Carvalho Andreucci Torres; Accorsi, Tarso Augusto Duenhas; Gualandro, Danielle Menosi; Oliveira Junior, Múcio Tavares de; Caramelli, Bruno; Kalil Filho, Roberto. Manual da residência em cardiologia / Manual residence in cardiology. Santana de Parnaíba, Manole, 2 ed; 2022. p.987-990.
Monography in Portuguese | LILACS | ID: biblio-1354094
3.
Med. lab ; 25(1): 363-392, 2021. tab, ilus, graf
Article in Spanish | LILACS | ID: biblio-1292640

ABSTRACT

Las enfermedades pueden generar un desequilibrio de electrolitos como parte de su fisiopatología, al igual que los medicamentos usados crónicamente y algunas sustancias tóxicas disponibles en nuestro medio. A pesar de todos los datos estadísticos existentes, la incidencia global de los trastornos electrolíticos secundarios a fármacos o sustancias tóxicas permanece desconocida, y, posiblemente, subregistrada; por lo tanto, el objetivo de esta revisión es analizar los trastornos electrolíticos que causan algunos medicamentos y sustancias tóxicas, y describir el mecanismo a través del cual se producen las alteraciones, en particular, del sodio, potasio, magnesio, calcio y fósforo, con el fin de alertar a los profesionales de la salud en el momento de enfrentarse a este tipo de condiciones en su práctica clínica. El conocimiento de los efectos adversos relacionados con medicamentos y tóxicos es importante para prevenir, identificar y gestionar de forma eficaz, complicaciones que son potencialmente peligrosas. Esta revisión pretende ser un referente de apoyo para los profesionales de la salud en estas situaciones


Diseases can generate an electrolyte imbalance as part of their pathophysiology, as well as chronic use of some medications, and toxic substances available in our environment. Despite all the separate statistical data, the overall incidence of fluid and electrolyte disorders secondary to drugs or toxic substances remains unknown, and possibly underreported; therefore, the objective of this review is to analyze electrolyte disorders caused by some medications and toxic substances, and describe the mechanism through which changes in sodium, potassium, magnesium, calcium and phosphorus occur, in particular, in order to alert health professionals when facing this type of conditions in their clinical practice. Knowledge of drug and toxic-related adverse effects is important to effectively prevent, identify, and manage complications that can be potentially life-threatening. This review intends to be a reference for supporting health professionals in these situations


Subject(s)
Electrolytes , Pharmaceutical Preparations , Sodium-Potassium-Exchanging ATPase , Diuretics , Ethanol , Toxicity
4.
Ciênc. cuid. saúde ; 20: e55696, 2021. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1356126

ABSTRACT

RESUMO Objetivo: avaliar os fatores de risco para quedas em pessoas idosas residentes na comunidade. Métodos: estudo descritivo, transversal e quantitativo, desenvolvido na região Nordeste do Brasil com 221 pessoas idosas residentes na comunidade. A coleta de dados ocorreu de junho a setembro de 2016 com a utilização de instrumentos estruturados. Realizou-se uma análise exploratória dos dados com medidas de tendência central, dispersão e associação entre as variáveis. Resultados: em relação ao perfil, observaram-se faixa etária entre 60 e 79 anos (75,6%); sexo feminino (70,6%); casados (43,9%); até quatro anos de escolaridade (33,9%); renda pessoal mensal de até um salário mínimo (45,7%) proveniente da aposentadoria (60,2%); três a cinco comorbidades (51,6%). Quanto ao risco para quedas, destacou-se como preditores a Fall Risk Score classificada como "alto risco", seguida por medicamentos antiparkinsonianos, antidepressivos e diuréticos, hipoglicemia, deficiência auditiva, dor, incontinência urinária e sintomas neurológicos. Conclusão: faz-se necessário estabelecer ações individuais e coletivas para a prevenção e promoção da saúde diante dos riscos para quedas. A rede de saúde deve trabalhar para possibilitar a conscientização de que as quedas constituem um problema de saúde pública e, por isso, ressalta-se a necessidade de cuidados direcionados, evitando consequências na qualidade de vida da pessoa idosa.


RESUMEN Objetivo: evaluar los factores de riesgo para caídas en personas mayores residentes en la comunidad. Métodos: estudio descriptivo, transversal y cuantitativo, desarrollado en la región Nordeste de Brasil con 221 personas mayores residentes en la comunidad. La recolección de datos tuvo lugar de junio a septiembre de 2016 con la utilización de instrumentos estructurados. Se realizó un análisis exploratorio de los datos con medidas de tendencia central, dispersión y asociación entre las variables. Resultados: en relación al perfil, se observaron franja etaria entre 60 y 79 años (75,6%); sexo femenino (70,6%); casados (43,9%); hasta cuatro años de escolaridad (33,9%); renta personal mensual de hasta un salario mínimo (45,7%) proveniente de la jubilación (60,2%); tres a cinco comorbilidades (51,6%). En cuanto al riesgo de caídas, se destacó como predictores la FallRisk Score clasificada como "alto riesgo", seguida por fármacosAntiparkinsonianos, antidepresivos y diuréticos, hipoglucemia, deficiencia auditiva, dolor, incontinencia urinaria y síntomas neurológicos. Conclusión: se hace necesario establecer acciones individuales y colectivas para la prevención y promoción de la salud frente a los riesgos para caídas. La red de salud debe trabajar para posibilitar la concienciación de que las caídas constituyen un problema de salud pública y, por eso, se resalta la necesidad de cuidados dirigidos, evitando consecuencias en la calidad de vida de la persona anciana.


ABSTRACT Objective: to assess risk factors for falls in elderly people living in the community. Methods: descriptive, cross-sectional, and quantitative study, developed in the Northeast region of Brazil with 221 elderly people living in the community. Data collection took place from June to September 2016 using structured instruments. An exploratory data analysis was performed with measures of central tendency, dispersion, and association between variables. Results: regarding the profile, there was an age group between 60 and 79 years old (75.6%); females (70.6%); married (43.9%); up to four years of education (33.9%); monthly personal income of up to one minimum wage (45.7%) from retirement (60.2%); three to five comorbidities (51.6%). As for the risk of falls, the Fall Risk Score classified as "high risk" stood out as predictors, followed by antiparkinsonian drugs, antidepressants and diuretics, hypoglycemia, hearing loss, pain, urinary incontinence, and neurological symptoms. Conclusion: it is necessary to establish individual and collective actions for the prevention and promotion of health because of the risks of falls. The health network must work to raise awareness that falls are a public health problem and, therefore, the need for targeted care is emphasized, avoiding consequences on the quality of life of elderly people.


Subject(s)
Humans , Female , Middle Aged , Aged , Accidental Falls , Aged , Risk Factors , Pain , Primary Health Care , Urinary Incontinence , Pharmaceutical Preparations , Nursing , Diuretics , Disease Prevention , Accident Prevention , Health Promotion , Hypoglycemia , Antidepressive Agents , Antiparkinson Agents
6.
Rev. colomb. cardiol ; 27(1): 44-48, ene.-feb. 2020. graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1138753

ABSTRACT

Resumen En la insuficiencia cardiaca terminal los síntomas predominantes habitualmente están relacionados con la congestión; sin embargo, la resistencia a diuréticos vía oral es frecuente y necesita tratamiento parenteral para paliar los síntomas. La administración intravenosa de furosemida requiere hospitalización o asistencia hospitalaria, lo que supone un deterioro significativo de la calidad de vida de pacientes en fases avanzadas de la enfermedad. La administración subcutánea continua de furosemida mediante infusor elastomérico es una técnica eficaz con baja tasa de complicaciones graves que permite la administración de diurético parenteral en el ámbito domiciliario, y evita la necesidad de hospitalizar. A pesar de que esta modalidad de tratamiento no está aceptada en ficha técnica y requiere más estudios que precisen su indicación, puede suponer un recurso adecuado para pacientes seleccionados. Se presenta el caso de una paciente con insuficiencia cardiaca avanzada, síntomas congestivos y ausencia de respuesta a tratamiento deplectivo vía oral, tratada con perfusión continua subcutánea domiciliaria de furosemida mediante infusor elastomérico de forma prolongada.


Abstract In end-stage heart failure the predominant symptoms are usually associated with congestion. However, the resistance to oral diuretics is common and requires parenteral treatment to alleviate the symptoms. The intravenous administration of furosemide requires hospital admission or hospital care. This leads to a significant decrease in the quality of life of patients in advance stages of the disease. The continuous subcutaneous infusion of furosemide using an elastomeric pump is an effective technique, with a low rate of serious complications that allows a parenteral diuretic to be administered in the home environment and thus avoiding the need for hospital admission. Despite this mode of treatment not being indicated in the drug data sheet, and requires more studies that specify its indication, it may be a suitable recourse for selected patients. It is presented a case of a patient with advanced heart failure, congestive symptoms, and a lack of response to oral diuretics treatment, and then treated with a continuous and prolonged subcutaneous infusion of furosemide at home using an elastomeric infusion pump.


Subject(s)
Humans , Female , Aged, 80 and over , Palliative Care , Heart Failure , Diuretics , Infusions, Subcutaneous , Furosemide
7.
Article in English | WPRIM | ID: wpr-786211

ABSTRACT

BACKGROUND AND OBJECTIVES: 2018 ESC/ESH Hypertension guideline recommends 2-drug combination as initial anti-hypertensive therapy. However, real-world evidence for effectiveness of recommended regimens remains limited. We aimed to compare the effectiveness of first-line anti-hypertensive treatment combining 2 out of the following classes: angiotensin-converting enzyme (ACE) inhibitors/angiotensin-receptor blocker (A), calcium channel blocker (C), and thiazide-type diuretics (D).METHODS: Treatment-naïve hypertensive adults without cardiovascular disease (CVD) who initiated dual anti-hypertensive medications were identified in 5 databases from US and Korea. The patients were matched for each comparison set by large-scale propensity score matching. Primary endpoint was all-cause mortality. Myocardial infarction, heart failure, stroke, and major adverse cardiac and cerebrovascular events as a composite outcome comprised the secondary measure.RESULTS: A total of 987,983 patients met the eligibility criteria. After matching, 222,686, 32,344, and 38,513 patients were allocated to A+C vs. A+D, C+D vs. A+C, and C+D vs. A+D comparison, respectively. There was no significant difference in the mortality during total of 1,806,077 person-years: A+C vs. A+D (hazard ratio [HR], 1.08; 95% confidence interval [CI], 0.97−1.20; p=0.127), C+D vs. A+C (HR, 0.93; 95% CI, 0.87−1.01; p=0.067), and C+D vs. A+D (HR, 1.18; 95% CI, 0.95−1.47; p=0.104). A+C was associated with a slightly higher risk of heart failure (HR, 1.09; 95% CI, 1.01−1.18; p=0.040) and stroke (HR, 1.08; 95% CI, 1.01−1.17; p=0.040) than A+D.CONCLUSIONS: There was no significant difference in mortality among A+C, A+D, and C+D combination treatment in patients without previous CVD. This finding was consistent across multi-national heterogeneous cohorts in real-world practice.


Subject(s)
Adult , Angiotensin Receptor Antagonists , Antihypertensive Agents , Calcium Channel Blockers , Calcium Channels , Cardiovascular Diseases , Cohort Studies , Diuretics , Heart Failure , Humans , Hypertension , Korea , Mortality , Myocardial Infarction , Propensity Score , Stroke
8.
Article in English | WPRIM | ID: wpr-811441

ABSTRACT

Hepatic hydrothorax is a transudative pleural effusion that complicates advanced liver cirrhosis. Patients refractory to medical treatment plus salt restriction and diuretics are considered to have refractory hepatic hydrothorax and may require transjugular intrahepatic portosystemic shunt (TIPS) or liver transplant. Successful antiviral therapy reduces the incidence of some complications of cirrhosis secondary to HCV infection. We report a case of hepatic hydrothorax in a 55-year-old female patient with HCV cirrhosis, which exhibited a spontaneous decrease in pleural effusion after direct antiviral agent (DAA) therapy. In cases of HCV cirrhosis, DAAs are worth administering before treatment by TIPS or liver transplantation.


Subject(s)
Antiviral Agents , Diuretics , Female , Fibrosis , Hepacivirus , Hepatitis C, Chronic , Hepatitis, Chronic , Humans , Hydrothorax , Incidence , Liver , Liver Cirrhosis , Liver Transplantation , Middle Aged , Pleural Effusion , Portasystemic Shunt, Surgical
10.
Arch. argent. pediatr ; 117(6): 626-630, dic. 2019. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1046470

ABSTRACT

El cierre prematuro del foramen oval o foramen oval restrictivo intraútero es una entidad rara de etiología desconocida. Dicha patología se asocia a un riesgo elevado de hipertensión pulmonar y puede ocasionar insuficiencia cardíaca congestiva con hidrops y muerte fetal. También, se puede asociar con disfunción diastólica en el período neonatal. Se presenta a un recién nacido en el que, en una ecografía prenatal, se visualizó un aumento de las cavidades derechas. En el ecocardiograma posnatal, se confirmó la dilatación de las cavidades derechas con hipertensión pulmonar en rango sistémico y septo interauricular inmóvil con foramen oval cerrado. A los 9 días, ante la persistencia de dificultad respiratoria, se realizó un ecocardiograma, con mejoría de la hipertensión pulmonar, pero con disfunción sistólica biventricular leve y diastólica del ventrículo izquierdo con edema pulmonar. Se indicó el tratamiento diurético, con normalización de la función ventricular.


Premature closure of the foramen ovale (FO) or intrauterine restrictive FO is a rare entity of unknown etiology. This pathology is associated with an elevated risk of pulmonary hypertension, which can cause congestive heart failure with hydrops and fetal death. Patients with restrictive intrauterine FO may develop left ventricle diastolic dysfunction and pulmonary edema. A newborn with increased right cavities in the prenatal ultrasound is presented. In postnatal echocardiogram, dilatation of right cavities was confirmed with pulmonary hypertension in the systemic range and immobile interatrial septum with closed FO. After 9 days of persistent respiratory distress, an echocardiogram was performed with improvement of pulmonary hypertension but with mild biventricular and diastolic and systolic dysfunction of the left ventricle with pulmonary edema. Diuretic treatment was decided, with normalization of ventricular function.


Subject(s)
Humans , Male , Infant, Newborn , Foramen Ovale , Hypertension, Pulmonary , Diuretics/therapeutic use
11.
Medicina (B.Aires) ; 79(6): 477-482, dic. 2019. graf, tab
Article in Spanish | LILACS | ID: biblio-1056756

ABSTRACT

La hipercalciuria idiopática se define como la excreció;n de calcio superior a 220 y 300 mg/día en mujeres y hombres respectivamente o bien mayor a 4 mg/kg peso. En mujeres con osteoporosis se observa en el 19% de los casos, mientras que en litiasis renal varía entre el 50 y 70%. Seleccionamos 206 pacientes hipercalció;ºricos, de nuestra base de datos, con y sin litiasis renal, a los que se les había indicado una dieta restringida. Luego los dividimos, de acuerdo a la respuesta, en dieta dependiente y dieta independiente. De estos solo consideramos 122 pacientes con diagnó;sticos de hipercalciuria dieta-dependiente (105 mujeres y 17 hombres), que fueron seguidos con control dietario (800 mg de calcio, alrededor de 1 g de proteínas animales y < 100 mEq de sodio diarios). No se consideró; la aparició;n de cálculos, o la recurrencia de los mismos, como tampoco el compromiso ó;seo. Luego de una media de 17 meses todos tenían controlada la calciuria e incluso hubo 16 (13%) que luego de 42 meses de seguimiento persistían normocalció;ºricos solo con dieta. Concluimos que es fundamental la divisió;n de las hipercalciurias, segó;ºn su respuesta a una dieta restringida, con el fin de evitar o postergar el uso de diuró;©ticos y sus efectos adversos, con una administració;n adecuada de la dieta.


Idiopathic hypercalciuria is defined as calcium excretion greater than 220 and 300 mg / day in women and men respectively, or greater than 4 mg / kg body weight. In women with osteoporosis it is observed in 19% of cases, while in kidney stones cases varies between 50 and 70%. We selected 206 hypercalciuric patients from our database, with and without renal lithiasis, to whom a restricted diet had been indicated. We divided them, according to the response, into a dependent diet and an independent diet. We considered 122 patients with diagnosis of hypercalciuria diet dependent (105 women and 17 men), which were followed with dietary control (800 mg of calcium, around 1 g of animal proteins and < 100 mEq sodium a day). The appearance of stones, or the recurrence of stones, was not considered, nor was bone involvement. After an average of 17 months, everyone had their calciuria controlled and there were even 16 (13%) who, after 42 months of follow-up, continued to be normocalciuric only on a diet. We conclude that the division of the hypercalciurias is fundamental, according to their response to a restricted diet, in order to avoid or postpone the use of diuretics and its adverse effects, with an adequate management of the diet.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Diuretics/therapeutic use , Hypercalciuria/diet therapy , Phosphorus/urine , Phosphorus/blood , Reference Values , Time Factors , Body Mass Index , Sex Factors , Calcium/urine , Calcium/blood , Follow-Up Studies , Treatment Outcome , Hypercalciuria/etiology
12.
Med. infant ; 26(2): 189-196, Junio 2019. Tab, ilus
Article in Spanish | LILACS | ID: biblio-1021542

ABSTRACT

La Insuficiencia Cardíaca (IC) es un síndrome clínico que epresenta una de las mayores causas de mobi-mortalidad en pacientes pediátricos. Refleja la incapacidad del corazón para satisfacer las necesidades metabólicas del organismo, incluido el crecimiento y el ejercicio. En el niño la causa más frecuente es la cardiopatía congénita. Otras causas las miocardiopatía, las miocarditis, las arritmias y las causas no cardíacas como: insuficiencia renal, hipertensión arterial, enfermedades pulmonares crónicas, anemia, sepsis, hiper e hipotiroidismo, cardiotoxicidad, etc. Clásicamente el tratamiento estaba dirigido a mejorar la contractilidad y evitar la retención hidrosalina con digital y diuréticos. En la actualidad, dado a la mejor comprensión del mecanismo fisiopatológico, en los últimos años, el tratamiento se centra en el control de los sistemas renina-angiotensina (SRAA) y nervioso simpático. En los casos de IC descompensada que presentan síndrome de bajo gasto cardíaco que no responde a la terapia médica, previo al trasplante cardíaco, está indicado el soporte mecánico (AU)


Heart failure (HF) reflects the inability of the heart to meet the metabolic needs of the body, including growth and exercise. In the child, the most common cause is congenital heart disease. Other causes are cardiomyopathy, myocarditis, arrhythmias, and non-cardiac causes, such as renal failure, high blood pressure, chronic pulmonary diseases, anemia, sepsis, hyper- and hypothyroidism, cardiotoxicity. Classically, the treatment aimed at improving contractility and avoiding salt and fluid retention using digitalis and diuretics. Given the current better understanding of the pathophysiological mechanism, over the past years treatment has focused on the control of renin-angiotensin (RAAS) and sympathetic nervous systems. In cases of decompensated HF with low cardiac output syndrome not responding to medical therapy, prior to cardiac transplantation mechanical support is indicated (AU)


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Heart Failure/etiology , Heart Failure/physiopathology , Heart Failure/drug therapy , Heart Failure/therapy , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Cardiotonic Agents/therapeutic use , Heart-Assist Devices , Adrenergic beta-Agonists/therapeutic use , Diuretics/therapeutic use
13.
J. bras. nefrol ; 41(2): 266-274, Apr.-June 2019. tab, graf
Article in English | LILACS | ID: biblio-1012534

ABSTRACT

Abstract Refractory hypertension (RfH) is an extreme phenotype of resistant hypertension (RH), being considered an uncontrolled blood pressure besides the use of 5 or more antihypertensive medications, including a long-acting thiazide diuretic and a mineralocorticoid antagonist. RH is common, with 10-20% of the general hypertensives, and its associated with renin angiotensin aldosterone system hyperactivity and excess fluid retention. RfH comprises 5-8% of the RH and seems to be influenced by increased sympathetic activity. RH patients are older and more obese than general hypertensives. It is strongly associated with diabetes, obstructive sleep apnea, and hyperaldosteronism status. RfH is more frequent in women, younger patients and Afro-americans compared to RFs. Both are associated with increased albuminuria, left ventricular hypertrophy, chronic kidney diseases, stroke, and cardiovascular diseases. The magnitude of the white-coat effect seems to be higher among RH patients. Intensification of diuretic therapy is indicated in RH, while in RfH, therapy failure imposes new treatment alternatives such as the use of sympatholytic therapies. In conclusion, both RH and RfH constitute challenges in clinical practice and should be addressed as distinct clinical entities by trained professionals who are capable to identify comorbidities and provide specific, diversified, and individualized treatment.


Resumo A Hipertensão Arterial Refratária (HARf) representa um fenótipo extremo da hipertensão arterial resistente (HAR), sendo considerada a falência ao tratamento apesar do uso de 5 ou mais classes de anti-hipertensivos, incluindo um diurético tiazídico de longa ação e um antagonista mineralocorticoide. A HAR é comum (10-20%) entre os hipertensos em geral, sendo decorrente de hiperatividade do Sistema Renina Angiotensina Aldosterona e retenção hidrossalina. Aqueles com HARf correspondem a 5-8% dos resistentes e parecem sofrer maior influência catecolaminérgica. Os resistentes tendem a ter maior idade, ao sobrepeso e à obesidade. Comorbidades incluem diabetes, apneia obstrutiva do sono e status de hiperaldosteronismo. Refratários são afro-americanos em maior proporção, mais jovens e, predominantemente, mulheres. Ambos são fortemente associados à elevada albuminúria, HVE, doenças cardio e cerebrovasculares, além da doença renal crônica. O fenômeno do jaleco branco parece ser mais evidente nos resistentes. Quanto ao tratamento, a intensificação da terapia diurética está indicada nos resistentes, enquanto na HARf, a falência à terapia impôs novas alternativas de tratamento ("simpaticolíticas"). Em conclusão, tanto a HAR quanto a HARf constituem-se desafios na prática clínica e devem ser abordadas como entidades clínicas distintas por profissionais especialistas que identifiquem comorbidades e venham a prover um tratamento específico, diversificado e individualizado.


Subject(s)
Humans , Drug Resistance , Hypertension/drug therapy , Hypertension/epidemiology , Phenotype , Sympatholytics/therapeutic use , Blood Pressure/drug effects , Complementary Therapies , Alcohol Drinking/adverse effects , Exercise , Smoking/adverse effects , Prevalence , Blood Pressure Monitoring, Ambulatory , Diet, Sodium-Restricted , Diuretics/pharmacology , Dietary Approaches To Stop Hypertension , Hypertension/diagnosis , Hypertension/physiopathology , Antihypertensive Agents/pharmacology
15.
Acta toxicol. argent ; 27(1): 5-12, mayo 2019. ilus, tab
Article in Spanish | LILACS | ID: biblio-1010977

ABSTRACT

Entre las situaciones asociadas al uso inapropiado de diuréticos se encuentran los intentos por descencer rápidamente de peso, comunes en los desordenes de la alimentación, y los intentos por enmascarar el consumo de otras sustancias, en el caso de las competencias deportivas. El uso sin indicación ni supervisión médica de estos fármacos genera un desbalance electrolítico, que puede manifestarse con hiponatremia, hipocalemia, hipocalcemia e hipomagnesemia, hipercalemia, entre otras alteraciones. El objetivo de este trabajo fue investigar las caracteríscas del uso inapropiado de diuréticos a partir de la casuística del CENATOXA. Se realizó un estudio descriptivo restrospectivo sobre los análisis ingresados al CENATOXA con solicitud de investigación cualitativa de diuréticos en orina, entre los años 2002 y 2016. En dicho período ingresaron al CENATOXA 138 casos, de los cuales el 56 % resultó positivo para algún diurético. Del total de casos con resultado positivo, el 93,5 % fueron mujeres entre 25 y 55 años de edad y predominó la etiología intencional. Los diuréticos mayoritariamente encontrados fueron hidroclorotiazida y furosemida. El perfil de diuréticos hasta el año 2008 (hidroclorotiazida = 68% de los casos positivos) se diferenció del hallado entre 2009 y 2016 (furosemida + hidroclorotiazida = 60% de los casos positivos). Se observó recurrencia en el uso inapropiado en el 8% de los casos. El uso simultáneo de más de un diurético y la recurrencia son factores que pueden contribuir a la aparición de toxicidad. Estos resultados sugieren que el uso inapropiado de diuréticos es una situación que debería ser ob­servada más atentamente para establecer mejor su alcance y sus riesgos.


Among the situations associated with diuretics misuse are the attempts to lose weight fast, frequently observed in eating disorders, and the attempts to mask the consumption of other substances, in the case of sports competitions. The use of these drugs with no medical indication or supervision generates an electrolyte imbalance, leading to hyponatremia, hypokalemia, hypocalcemia and hypomagnesemia, hyperkalemia, among other alterations. The objective of this work was to investigate the characteristics of diuretics misuse from the CENATOXA database, where the qualitative investigation of diuretics in urine is per­formed. A descriptive retrospective study was conducted on the cases admitted to the CENATOXA with a request for qualitative diuretic investigation, between 2002 and 2016. During this period, 138 urine samples were received at the CENATOXA and 56% were positive for at least one diuretic. Of all cases with positive results, 93.5% were women between 25 and 55 years of age, and intentional etiology predominated. The most detected diuretics were hydrochlorothiazide and furosemide. The diuretic misuse pattern detected up to 2008 (hydrochlorothiazide = 68% of positive cases) differed from that detected between 2009 and 2016 (furosemide + hydrochlorothiazide = 60% of positive cases). Recurrence in misuse was observed in 8% of the cases. The simul­taneous misuse of more than one diuretic and the recurrence are factors that can contribute to the onset of toxicity. These results suggest that diuretic misuse is a situation that should be observed more closely to better assess its consequences and its risks.


Subject(s)
Humans , Female , Adult , Middle Aged , Diuretics/adverse effects , Diuretics/urine , Hypocalcemia/chemically induced , Hypocalcemia/urine , Argentina/epidemiology , Feeding and Eating Disorders/urine , Retrospective Studies , Diuretics/toxicity , Drug Misuse , Furosemide/adverse effects , Hydrochlorothiazide/adverse effects
16.
Arq. bras. cardiol ; 112(1): 87-90, Jan. 2019. tab
Article in English | LILACS | ID: biblio-1038534

ABSTRACT

Abstract Blood pressure (BP)-lowering therapy improves left ventricular (LV) parameters of hypertensive target-organ damage in stage II hypertension, but whether there is a drug-class difference in echocardiographic parameters in stage I hypertension patients is less often studied. In the PREVER treatment study, where individuals with stage I hypertension were randomized for treatment with diuretics (chlorthalidone/amiloride) or losartan, 110 participants accepted to participate in a sub-study, where two-dimensional echocardiograms were performed at baseline and after 18 months of antihypertensive treatment. As in the general study, systolic BP reduction was similar with diuretics or with losartan. Echocardiographic parameters showed small but significant changes in both treatment groups, with a favorable LV remodeling with antihypertensive treatment for 18 months when target blood pressure was achieved either with chlorthalidone/amiloride or with losartan as the initial treatment strategy. In conclusion, even in stage I hypertension, blood pressure reduction is associated with improvement in echocardiographic parameters, either with diuretics or losartan as first-drug regimens.


Resumo A terapia de redução da pressão arterial (PA) melhora os parâmetros do ventrículo esquerdo (VE) na lesão a órgãos-alvo causada pela condição hipertensiva na hipertensão de estágio II; no entanto, se existem ou não diferenças relacionadas à classe de medicamentos nos parâmetros ecocardiográficos de pacientes com hipertensão estágio I é menos frequentemente estudado. No estudo PREVER-treatment, em que indivíduos com hipertensão estágio I foram randomizados para tratamento com diuréticos (clortalidona/amilorida) ou losartana, 110 participantes aceitaram participar de um subestudo, no qual foram realizados ecocardiogramas bidimensionais basais e após 18 meses de tratamento anti-hipertensivo. Como no estudo geral, a redução da PA sistólica foi semelhante com diuréticos ou com losartana. Os parâmetros ecocardiográficos mostraram pequenas mas significativas alterações em ambos os grupos de tratamento, com um remodelamento favorável do VE com tratamento anti-hipertensivo por 18 meses, quando a pressão arterial alvo foi atingida com clortalidona/amilorida ou com losartana como estratégia inicial de tratamento. Em conclusão, mesmo na hipertensão estágio I, a redução da pressão arterial está associada à melhora nos parâmetros ecocardiográficos tanto com o uso de diuréticos ou losartana como primeiro esquema de tratamento farmacológico.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Losartan/therapeutic use , Diuretics/therapeutic use , Amiloride/therapeutic use , Hypertension/drug therapy , Antihypertensive Agents/therapeutic use , Time Factors , Blood Pressure/drug effects , Echocardiography , Double-Blind Method , Follow-Up Studies , Treatment Outcome , Losartan/pharmacology , Ventricular Remodeling/drug effects , Diuretics/pharmacology , Amiloride/pharmacology , Hypertension/diagnostic imaging , Antihypertensive Agents/pharmacology
17.
São Paulo; s.n; 2019.
Monography in Portuguese | ColecionaSUS, LILACS, ColecionaSUS, SMS-SP, CACHOEIRINHA-Producao, SMS-SP | ID: biblio-1140680

ABSTRACT

Os diuréticos, no tratamento da Displasia Broncopulmonar (DBP), têm como função diminuir a retenção hídrica e auxiliar a reabsorção do edema intersticial dos pulmões. É uma doença crônica causada pela inflamação da membrana pulmonar e sua morbidade é mais comum em recém-nascidos com extremo baixo peso (EBP). O tratamento com diuréticos incluem os de alça, os tiazídicos e os poupadores de potássio. Objetivo: analisar possíveis efeitos da terapia com diuréticos sobre os íons de cálcio, sódio e potássio de amostras de sangue e urina dos neonatos diagnosticados com Displasia Broncopulmonar. Resultados: As concentrações séricas de sódio apresentaram variações abaixo dos valores mínimos de referência sendo suas alterações creditadas ao uso farmacológico. Outros resultados apresentaram limitações sendo um dificultador do estudo. Palavras-chave: displasia broncopulmonar; prematuridade; diuréticos; eventos adversos


Subject(s)
Bronchopulmonary Dysplasia , Infant, Premature , Diuretics/adverse effects
18.
Article in Chinese | WPRIM | ID: wpr-777470

ABSTRACT

Based on the toxic characteristics caused by the compatibility between "Zaoji Suiyuan" and Glycyrrhizae Radix et Rhizoma, which was found in the previous studies, the expanded study was carried out on the incompatibility mechanism between Crotonis Semen Pulveratum(CT) and Glycyrrhizae Radix et Rhizoma(GU) with the diuretic effect and intestinal flora as the characteristic indexes. The results showed that GU could slow down the rapid diuretic effect of CT, which suggested a tendency of decreasing the efficacy. Both the high and low dose of CT could significantly induce the intestinal injury and change the intestinal bacteria structure of mice. Low dose CT combined with GU could significantly increase the levels of Streptococcus and Rikenellaceae_ukn. The relative abundance of Desulfovibrio and Streptococcaceae_ukn were increased after the combined application of high dose CT and GU. It also suggested that there was a risk of inflammation in the liver and intestines when combined application of these two herbs. The results revealed that the combination of CT and GU has a tendency to reduce the clinical effect and increase the toxicity from the aspects of its traditional efficacy and its effect on intestinal microflora structure, which could provide the data for the clinical use of CT.


Subject(s)
Animals , Croton , Chemistry , Diuretics , Drug Interactions , Drugs, Chinese Herbal , Pharmacology , Gastrointestinal Microbiome , Glycyrrhiza , Chemistry , Intestines , Mice , Plant Roots , Chemistry , Seeds , Chemistry
19.
Article in English | WPRIM | ID: wpr-785580

ABSTRACT

Contrast-associated acute kidney injury (CA-AKI) is a major concern when iodinated contrast material is administered, especially in patients at risk. Efforts have been undertaken to understand the detrimental effects of contrast media (CM). With the use of low-osmolar or iso-osmolar CM the incidence of CA-AKI has steadily decreased within the past decade; however, especially in the pediatric population information is scarce. Incidence rates have been reported to range between 0% to 18.75%, particularly depending on indication, selection of population (i.e. preexisting co-morbidities), and definition of AKI. Different biomarkers have been proposed, but confirmatory studies are either lacking or have contributed to their lack of diagnostic power. Proteomic approaches have been employed and may pave the way to such discovery. Prevention strategies have been tested and proposed, but the recently published AMACING and PRESERVE trials have shown that commonly used strategies (such as systematic hydration or administration of N-acetylcysteine) have no role in the prevention of CA-AKI. We propose that thoughtful assessment of one's fluid state is the most appropriate approach and depending on the hydration status diuretics or fluid administration should be provided to achieve an euvolemic state ahead of contrast exposure.


Subject(s)
Acute Kidney Injury , Biomarkers , Child , Contrast Media , Diuretics , Humans , Incidence , Renal Insufficiency
20.
Journal of Korean Diabetes ; : 127-135, 2019.
Article in Korean | WPRIM | ID: wpr-761493

ABSTRACT

Diabetes mellitus (DM) is linked to poor outcomes after cardiovascular events and renal complications. Recently, novel antidiabetic agents, such as dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter 2 (SGLT2) inhibitors, and glucagon-like peptide-1 receptor agonists, are available. Among them, studies on SGLT2 inhibitors show favorable results both for cardiovascular and renal outcomes. SGLT2 inhibitors are well-tolerated with few side effects. Urinary tract infection has not been increased in many studies of SGLT2 inhibitors. The most frequent side-effect associated with SGLT2 inhibitors is mycotic infections in the genital area. Fortunately, these are generally mild in severity and easily treated with antibiotics. Hypoglycemia can occur when an SGLT2 inhibitor is added to sulfonylureas or insulin. Volume depletion and hypotension can be minimized by adjusting diuretics or other antihypertensive agents. Of note, acute kidney injury was observed in a few studies with SGLT2 inhibitors. However, in more recent observational studies, acute kidney injury was less frequently observed in conjunction with SGLT2 inhibitor treatment. An increased incidence of lower extremity amputation and fractures was observed in a large study with canagliflozin but not with other SGLT2 inhibitors. In conclusion, it is critical to understand the benefits and risks associated with use of SGLT2 inhibitors.


Subject(s)
Acute Kidney Injury , Amputation , Anti-Bacterial Agents , Antihypertensive Agents , Canagliflozin , Diabetes Mellitus , Diuretics , Glucagon-Like Peptide-1 Receptor , Hypoglycemia , Hypoglycemic Agents , Hypotension , Incidence , Insulin , Lower Extremity , Risk Assessment , Urinary Tract Infections
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