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1.
Arch. argent. pediatr ; 120(1): e34-e38, feb 2022. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1353770

ABSTRACT

Los xantomas cutáneos reflejan el depósito de lípidos en la piel y pueden ser la única manifestación temprana de dislipidemias de inicio en la infancia. Las características y distribución de los xantomas orientan a la patología de base; los xantomas tuberosos tienen una fuerte asociación con la hipercolesterolemia homocigota familiar, una patología muy infrecuente. Su detección temprana otorga una ventana terapéutica para prevenir la ateroesclerosis acelerada y la mortalidad. Se presenta el caso de una paciente que comenzó a los dos años con xantomas tuberosos, que fueron la clave diagnóstica para identificar la hipercolesterolemia homocigota familiar subyacente.


Cutaneous xanthomas reflect lipid deposition on the skin and may be the only early manifestation of a childhoodonset dyslipidemia. Characteristics and distribution of the xanthomas signalize the underlying pathology, tuberousxanthomas being strongly associated with homozygous familial hypercholesterolaemia, an extremely rare condition. Its early detection provides a therapeutic window to prevent accelerated atherosclerosis and mortality. We present the case of a patient who started at two years with tuberous xanthomas, which were the diagnostic clue to identify the underlying homozygous familial hypercholesterolaemia.


Subject(s)
Humans , Female , Child, Preschool , Xanthomatosis/diagnosis , Xanthomatosis/etiology , Xanthomatosis/drug therapy , Dyslipidemias , Hypercholesterolemia , Skin , Early Diagnosis
2.
Esc. Anna Nery Rev. Enferm ; 26: e20210281, 2022. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1356218

ABSTRACT

Resumo Objetivo investigar fatores de risco para doenças cardiovasculares e compreender as práticas de cuidado de mulheres. Método paralelo convergente misto. A etapa quantitativa foi transversal descritiva com formulário abordando características demográficas, socioeconômicas, fatores de risco cardiovascular, hábitos de vida e saúde, participaram 289 mulheres e aplicou-se estatística descritiva. A etapa qualitativa foi fundamentada na pesquisa participativa, exploratória descritiva, mediante entrevista semiestruturada, técnica de criatividade e sensibilidade e narrativas, com 30 mulheres. Resultados identificaram-se fatores como sedentarismo (60,9%), uso do anticoncepcional (57,9%), estresse (60,6%), depressão (40,1%), obesidade (38,8%), hipertensão arterial (33,6%), consumo de bebida alcoólica (29,8%), cigarro (16,6%), dislipidemia (25,6%) e diabetes (10,0%). Quanto aos saberes e práticas de cuidado, as participantes mencionaram os fatores, porém algumas relataram realizar os cuidados, e outras não, mesmo reconhecendo os riscos. Assim, compartilharam a falta de tempo para realizar exercícios físicos, dificuldades para cuidar da alimentação e aderir ao tratamento anti-hipertensivo e, ainda, relataram sentirem-se estressadas. Conclusão e implicações para a prática identificaram-se fatores modificáveis e as mulheres possuíam conhecimento acerca destes, entretanto divergiam sobre os cuidados, demonstrando a importância de ações voltadas a essa população.


Resumen Objetivo investigar los factores de riesgo para enfermedades cardiovasculares y comprender las prácticas de atención brindadas a las mujeres. Método paralelo convergente mixto. La etapa cuantitativa fue transversal transcriptiva con formulario abordando características demográficas, socioeconómicas, factores de riesgo cardiovascular, hábitos de vida y salud. Participaron 289 mujeres y se aplicó estadística descriptiva. La etapa cualitativa fue fundamentada en la investigación participativa, exploratoria descriptiva, mediante entrevista semiestructurada, técnica de creatividad y sensibilidad y narrativas, con 30 mujeres. Resultados se identificaron factores como sedentarismo (60,9%), uso de anticonceptivos (57,9%), estrés (60,6%), depresión (40,1%), obesidad (38,8%), hipertensión arterial (33,6%), consumo de bebidas alcohólicas (29,8%), tabaquismo (16,6%), dislipidemia (25,6%) y diabetes (10,0%). En cuanto a los conocimientos y prácticas de cuidado, las participantes mencionaron los factores, sin embargo, algunas reportaron realizar el cuidado y otras no, inclusive reconociendo los riesgos. Así, compartieron la falta de tiempo para la realización de actividades físicas, dificultades para cuidar su alimentación y la adherencia al tratamiento antihipertensivo e, inclusive, refirieron sentirse estresadas. Conclusión e implicaciones para la práctica se identificaron factores modificables y las mujeres tenían conocimiento sobre ellos, sin embargo, divergieron sobre el cuidado, demostrando la importancia de las acciones dirigidas a esta población.


Abstract Objective to investigate risk factors for cardiovascular disease and understand the care practices of women. Method mixed convergent parallel. The quantitative stage was descriptive transversal with a form addressing demographic characteristics, socioeconomic, cardiovascular risk factors, lifestyle and health habits; 289 women participated and descriptive statistics were applied. The qualitative step was based on participatory research, exploratory descriptive, through semi-structured interviews, creativity and sensitivity technique and narratives, with 30 women. Results factors were identified as sedentarism (60.9%), use of contraceptives (57.9%), stress (60.6%), depression (40.1%), obesity (38.8%), high blood pressure (33.6%), alcohol consumption (29.8%), smoking (16.6%), dyslipidemia (25.6%), and diabetes (10.0%). As for knowledge and care practices, the participants mentioned the factors, but some reported performing the care, and others did not, even though they recognized the risks. Thus, they shared the lack of time to perform physical exercises, difficulties to take care of the diet and adhere to antihypertensive treatment, and also reported feeling stressed. Conclusion and implications for practice modifiable factors were identified and women had knowledge about these, however, they differed on the care, demonstrating the importance of actions aimed at this population.


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Cardiovascular Diseases/prevention & control , Women's Health/statistics & numerical data , Heart Disease Risk Factors , Self Care , Stress, Psychological , Alcohol Drinking , Smoking , Workload , Contraceptive Agents/adverse effects , Depression , Dyslipidemias , Overweight , Sedentary Behavior , Healthy Lifestyle , Diet, Healthy , Hypertension
4.
In. Soeiro, Alexandre de Matos; Leal, Tatiana de Carvalho Andreucci Torres; Accorsi, Tarso Augusto Duenhas; Gualandro, Danielle Menosi; Oliveira Junior, Múcio Tavares de; Caramelli, Bruno; Kalil Filho, Roberto. Manual da residência em cardiologia / Manual residence in cardiology. Santana de Parnaíba, Manole, 2 ed; 2022. p.788-792, tab.
Monography in Portuguese | LILACS | ID: biblio-1353341
5.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1366183

ABSTRACT

Objetivo: avaliar a frequência e os fatores associados à dislipidemia em pessoas com Diabetes Mellitus Tipo 2. Método: estudo transversal, desenvolvido com 45 pessoas diagnosticadas com diabetes e acompanhadas por uma Unidade Básica de Saúde. Foram investigadas variáveis sociodemográficas, relacionadas ao estilo de vida e referentes à análise do perfil lipídico. Resultados: a prevalência de dislipidemia foi de 82,2%, significativamente associada ao sexo feminino (p=0,005), ao tabagismo (p=0,002) e ao sedentarismo (p=0,050). Nos componentes da dislipidemia, as taxas de colesterol total, triglicérides e LDL se mostraram elevados em 68,9%, 57,8%, 11,1%, respectivamente. Já a taxa de HDL se mostrou diminuída em 2,2% dos investigados. Conclusão: a prevalência de dislipidemia mostrou-se elevada nos pacientes analisados. A existência de associação significativa entre a ocorrência de dislipidemia e variáveis como o sexo feminino, os hábitos de tabagismo e sedentarismo chama a atenção para a necessidade de melhores condutas para essa população


Objective: to evaluate the frequency and factors associated with dyslipidemia in people with type 2 Diabetes Mellitus. Method: cross-sectional study, carried out with 45 people diagnosed with diabetes and followed up at a Basic Health Unit. Sociodemographic variables related to lifestyle and related to lipid profile analysis were investigated. Results: the prevalence of dyslipidemia was 82.2%, significantly associated with female gender (p = 0.005), smoking (p = 0.002) and sedentary lifestyle (p = 0.050). The components of dyslipidemia, total cholesterol, triglycerides and low-density lipoproteins were elevated in 68.9%, 57.8% and 11.1%, respectively. Conclusion: the prevalence of dyslipidemia was high in the patients analyzed. The existence of a significant association between the occurrence of dyslipidemia and different types of females, smoking habits and sedentary lifestyle calls attention to the need for better conduct for this population


Objetivo: evaluar la frecuencia y los factores asociados a la dislipidemia en personas con Diabetes Mellitus tipo 2. Método: estudio transversal, desarrollado con 45 personas diagnosticadas con diabetes y acompañadas por una Unidad Básica de Salud. Se investigaron las variables sociodemográficas, de estilo de vida y de análisis del perfil lipídico. Resultados: la prevalencia de dislipidemia fue del 82,2%, asociada significativamente al sexo femenino (p=0,005), al tabaquismo (p=0,002) y al sedentarismo (p=0,050). En los componentes de la dislipidemia, las tasas de colesterol total, triglicéridos y lipoproteínas de baja densidad estaban elevadas en el 68,9%, 57,8% y 11,1%, respectivamente. Conclusión: la prevalencia de la dislipidemia fue elevada en los pacientes analizados. La existencia de una asociación significativa entre la ocurrencia de dislipidemia y variables como el sexo femenino, los hábitos de tabaquismo y el sedentarismo hace que se preste atención a la necesidad de mejores conductas para esta población


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Diabetes Mellitus, Type 2/prevention & control , Dyslipidemias/epidemiology , Life Style , Primary Health Care , Tobacco Use Disorder , Cross-Sectional Studies , Sedentary Behavior
6.
Ciênc. Saúde Colet ; 26(11): 5765-5776, nov. 2021. tab
Article in English, Portuguese | LILACS | ID: biblio-1350449

ABSTRACT

Resumo O presente artigo objetivou estimar a prevalência de dislipidemias e sua associação e adequação da ingestão de gorduras saturadas, monoinsaturadas, trans, ômega-3 e carboidratos, em adultos de Viçosa-MG. Trata-se de um estudo transversal com 884 adultos com idades entre 20 e 59 anos. Foram coletados dados sociodemográficos, de consumo alimentar, antropométricos e bioquímicos da população. As associações entre as variáveis foram verificadas utilizando-se o teste qui-quadrado. Verificou-se elevada prevalência de dislipidemias na população (64,25%), com pelo menos um dos lipídeos séricos alterados. Houve predomínio de inadequação na ingestão de gorduras saturadas, trans, monoinsaturadas e carboidratos. Ressalta-se que a ingestão de ômega-3 esteve adequado para a maioria dos indivíduos. Adultos eutróficos apresentaram maiores prevalências de ingestão excessiva de gorduras saturadas e trans. Observou-se que 38,7% dos indivíduos com HDL-c reduzido apresentaram ingestão acima do recomendado de gordura saturada. A maioria dos indivíduos com triglicerídeos e razão TG/HDL-c elevada possuíam ingestão insatisfatória de gordura monoinsaturada. Faz-se necessária a avaliação de outros fatores que podem influenciar o padrão alimentar.


Abstract This study aimed to assess the prevalence of dyslipidemia and its association with an adequate intake of carbohydrates, saturated, monounsaturated, trans, and omega-3 fats among adults living in Viçosa, Minas Gerais, Brazil. This is a cross-sectional study with 884 adults aged 20 to 59 years. Sociodemographic, food intake, anthropometric, and biochemical data were collected. Associations between study variables were investigated by the chi-square test. There was a high prevalence of dyslipidemia in the study population (64.25%), with most individuals having abnormal levels of at least one serum lipid component. Inadequate intakes of saturated, trans, and monounsaturated fats and carbohydrates were predominant. It is noteworthy that omega-3 intake levels were adequate in most individuals. Eutrophic adults showed a higher prevalence of excessive intake of saturated and trans fats. It was found that 38.7% of individuals with low levels of High Density Lipoprotein cholesterol (HDL-c) had an excessive intake of saturated fat. Most individuals with high triglyceride levels or high triglyceride/HDL-c ratios had an insufficient intake of monounsaturated fat. Further studies are needed to evaluate other factors that may influence dietary patterns.


Subject(s)
Humans , Pregnancy , Dietary Fats , Dyslipidemias/epidemiology , Prevalence , Cross-Sectional Studies , Cholesterol, HDL
7.
Prensa méd. argent ; 107(7): 366-373, 20210000. fig, graf, tab
Article in English | LILACS, BINACIS | ID: biblio-1358960

ABSTRACT

Contexto y objetivo: las anomalías hematológicas se encuentran entre las complicaciones más comunes de la infección por el VIH. También se han realizado bastantes estudios sobre las alteraciones en el perfil de lípidos, aunque los resultados en gran medida no han sido concluyentes. El presente estudio se llevó a cabo para evaluar el recuento de células CD4 y el perfil de lípidos en los pacientes infectados por el VIH y el SIDA en la población india y los correlaciona con los controles sero-negativos. Materiales y métodos: El presente estudio fue diseñado como un estudio transversal, con base en un hospital, para evaluar el recuento de células CD4 y el perfil de lípidos en los pacientes infectados por VIH y SIDA en la población india y los correlaciona con los controles sero-negativos. La evaluación del perfil de lípidos se realizó utilizando Erba EM 360, un analizador automático impulsado por un fotómetro de rejilla de difracción, mientras que los recuentos de células CD4 se evaluaron utilizando el Contador de ciclo de Partec. Análisis estadístico utilizado: Los datos se analizaron con SPSS versión 15.0 (SPSS Inc., Chicago, IL, EE. UU.). La comparación de dichos parámetros se realizó mediante el análisis de varianza (ANOVA) y la prueba post-hoc de Games-Howell. Se consideró estadísticamente significativo un valor de p <0,05. Resultados: Los niveles de colesterol total y lipoproteínas de baja densidad (LDL) disminuyeron significativamente, mientras que los triglicéridos y las lipoproteínas de muy baja densidad (VLDL) aumentaron significativamente en los pacientes infectados por VIH y SIDA en comparación con los controles sero-negativos. Conclusión: El colesterol total, las LDL, los triglicéridos y las VLDL se alteraron significativamente en los pacientes infectados por VIH y con SIDA en comparación con los controles sero-negativos


Context and Aim: Hematological abnormalities are amongst the most common complications of infection with HIV.There have been quite a few studies on the alterations in lipid profile, too, though the results have largely been inconclusive. The present study was carried-out to assess CD4 cell counts and lipid profile in the HIV infected and AIDS patients in the Indian population and correlates them with the sero-negative controls. Materials and Methods: The present study was designed as a cross-sectional, hospital-based study to assess CD4 cell counts and lipid profile in the HIV infected and AIDS patients in the Indian population and correlates them with the sero-negative controls. Evaluation of lipid profile was done using Erba EM 360, an automated analyzer powered by a diffraction grating photometer while CD4 cell counts were evaluated using Partec Cyflow Counter. Statistical analysis used: The data was analyzed using SPSS version 15.0 (SPSS Inc., Chicago, IL, USA). Comparison of the said parameters was done using Analysis of Variance (ANOVA) and post-hoc Games-Howell test. p-value of <0.05 was considered statistically significant. Results: The levels of total cholesterol and low-density lipoproteins (LDLs) were significantly decreased while triglycerides and very low density lipoproteins (VLDLs) were significantly increased in the HIV infected and AIDS patients when compared with the sero-negative controls. Conclusion: Total cholesterol, LDLs, triglycerides and VLDLs were significantly altered in the HIV infected and AIDS patients when compared with the sero-negative controls


Subject(s)
Humans , Acquired Immunodeficiency Syndrome/complications , CD4 Lymphocyte Count , Dyslipidemias , Hematologic Diseases/complications
8.
Femina ; 49(9): 525-529, 20211030. tab
Article in Portuguese | LILACS | ID: biblio-1342321

ABSTRACT

A dislipidemia é um distúrbio metabólico frequente na síndrome dos ovários policísticos (SOP) e, possivelmente, contribui para um aumento do risco de doenças cardiovasculares. A avaliação do risco cardiovascular de cada paciente define as metas lipídicas a serem atingidas por meio da terapêutica recomendada para a correção da dislipidemia. Alimentação saudável, perda de peso e implementação de um programa regular de atividade física contribuem para a melhora do perfil lipídico. A terapia farmacológica deve ser reservada para as pacientes que não atingiram as metas lipídicas após modificações na dieta e regularização da atividade física ou nas pacientes com alto risco cardiometabólico.(AU)


Subject(s)
Humans , Female , Polycystic Ovary Syndrome , Dyslipidemias/diagnosis , Dyslipidemias/diet therapy , Dyslipidemias/drug therapy , Dyslipidemias/therapy , Exercise , Heart Disease Risk Factors
9.
Femina ; 49(9): 520-524, 20211030.
Article in Portuguese | LILACS | ID: biblio-1342318

ABSTRACT

A síndrome dos ovários policísticos (SOP) é frequentemente acompanhada de distúrbio metabólico, principalmente dos carboidratos e dos lipídeos, aumentando o risco de síndrome metabólica. Por essa razão, alguns investigadores ainda denominam a SOP de síndrome metabólica-reprodutiva. O objetivo deste capítulo é descrever as principais repercussões metabólicas, bem como como investigá-las e saber como suas consequências podem ser deletérias para a saúde da mulher. Esta é uma revisão narrativa mostrando a implicação do metabolismo dos carboidratos e dos lipídeos nas dislipidemias, bem como da síndrome metabólica sobre o sistema reprodutor, e o risco cardiovascular da mulher com SOP. Conclui-se que o manejo adequado dos distúrbios metabólicos na SOP é benéfico a curto e a longo prazo tanto para o sistema reprodutor quanto para o cardiovascular.(AU)


Subject(s)
Humans , Female , Polycystic Ovary Syndrome/metabolism , Metabolic Syndrome/diagnosis , Metabolic Syndrome/physiopathology , Insulin Resistance , Risk Factors , Glucose Intolerance/diagnosis , Glucose Metabolism Disorders/physiopathology , Diabetes Mellitus, Type 2/diagnosis , Dyslipidemias/physiopathology , Lipid Metabolism Disorders/physiopathology
10.
Rev. Hosp. Ital. B. Aires (2004) ; 41(3): 135-139, sept. 2021. ilus, tab
Article in Spanish | LILACS, BINACIS, UNISALUD | ID: biblio-1363153

ABSTRACT

Las variantes de ANGPTL3 con pérdida de función están asociadas con efectos beneficiosos sobre el metabolismo lipídico y de carbohidratos y con riesgo reducido de enfermedad coronaria. Los cambios beneficiosos en los parámetros lipídicos que se obtienen con la inhibición de ANGPTL3 junto con la reducción en aterosclerosis que se observa en modelos animales y en estudios epidemiológicos de genética humana hacen de ANGPTL3 un nuevo objetivo terapéutico para prevenir las enfermedades cardiovasculares. Dos estrategias novedosas han surgido para inhibir esta proteína: un anticuerpo monoclonal y un oligonucleótido antisentido, con capacidad para reducir tanto el colesterol como los triglicéridos plasmáticos en forma notoria. Aunque el horizonte es promisorio, todavía no sabemos si los efectos de una variante presente desde el comienzo de la vida serán reproducidos por la inhibición de esta proteína que se realiza más tarde en la vida a través de una intervención farmacológica. (AU)


Loss-of-function ANGPTL3 variants are associated with beneficial effects on carbohydrate and lipid metabolism, and reduced risk of coronary heart disease. The beneficial changes in lipid parameters obtained by ANGPTL3 inhibition together with atheroprotection observed in animal models and in epi-demiological studies of human genetics make ANGPTL3 a new therapeutic target to prevent cardiovascular diseases. Two novel strategies have emerged to inhibit this protein: a monoclonal antibody and an antisense oligonucleotide, with the ability to significantly lower plasma cholesterol and triglycerides. Although the horizon is promising, we still do not know if the effects of a variant present from the beginning of life will be reproduced by the inhibition of this protein that takes place later in life through a pharmacological intervention. (AU)


Subject(s)
Humans , Dyslipidemias/drug therapy , Angiopoietin-like Proteins/therapeutic use , Angiopoietin-like Proteins/pharmacology , Triglycerides/blood , Cardiovascular Diseases/prevention & control , Cholesterol/blood , Oligonucleotides, Antisense/pharmacology , Antibodies, Monoclonal/metabolism
12.
Arq. bras. cardiol ; 117(2): 270-278, ago. 2021. tab, graf
Article in Portuguese | LILACS | ID: biblio-1339144

ABSTRACT

Resumo Fundamento: O uso de estatinas destaca-se como a terapia mais frequentemente utilizada para o tratamento de dislipidemias e pode ser considerado a intervenção farmacológica mais eficiente para a redução da lipoproteína de baixa densidade (LDL). Por outro lado, o treinamento físico pode ser considerado uma estratégia não farmacológica eficiente e segura para promover melhorias no perfil lipídico. No entanto, não se sabe qual seria a influência das estatinas nas adaptações lipídicas decorrentes do treinamento aquático em populações com dislipidemia. Objetivos: Analisar a influência do uso de sinvastatina nas adaptações lipídicas decorrentes do treinamento aeróbico em meio aquático e de resistência em mulheres idosas com dislipidemia. Métodos: Sessenta e nove mulheres idosas (66,13 ± 5,13 anos), sedentárias e dislipidêmicas, tanto não usuárias quanto usuárias de sinvastatina (20 mg e 40 mg), foram randomizadas nos 3 grupos seguintes: treinamento aeróbico em meio aquático (WA), treinamento de força em meio aquático (WR) e grupo controle (GC). A duração total das intervenções, para todos os grupos experimentais, foi de 10 semanas, com 2 sessões semanais. As análises bioquímicas foram realizadas antes do início das intervenções e repetidas após o final do ensaio. Foram utilizadas equações de estimativa generalizada para comparar esses dados, estabelecendo α = 0,05. Resultados: Na análise por intenção de tratar, as participantes medicadas demonstraram uma redução de magnitude maior do colesterol total (CT) (−3,41 a −25,89 mg.dl−1; p = 0,038), LDL (−5,58 a −25,18 mg.dl−1; p = 0,007) e da relação CT/HDL (−0,37 a −0,61; p = 0,022) quando comparadas às participantes não medicadas, essa redução sendo estatisticamente significativa apenas no grupo WR. Conclusões: O uso de estatina incrementa as adaptações promovidas pelo treinamento físico aquático no CT, nos níveis de LDL e na relação CT/HDL, sendo mais pronunciado após WR.


Abstract Background: Statin use is highlighted as the most commonly utilized therapy for the treatment of dyslipidemias and can be considered as the most efficient pharmacological intervention for low-density lipoprotein (LDL) reduction. On the other hand, physical training can be considered an efficient and safe non-pharmacological strategy to promote improvements in lipid profile. However, the influence of statins on lipid adaptations arising from water-based training in populations with dyslipidemia is not known. Objectives: To analyze the influence of simvastatin use on lipid adaptations arising from water-based aerobics and resistance training in elderly women with dyslipidemia. Methods: Sixty-nine elderly (66.13 ± 5.13 years), sedentary, and dyslipidemic women, both non-users and users of simvastatin (20 mg and 40 mg), were randomized into the following 3 groups: water-based aerobic training (WA), water-based resistance training (WR), and control group (CG). Total duration of interventions, for all experimental groups consisted of 10 weeks, with 2 weekly sessions. Biochemical analyses were performed before the beginning of the interventions and repeated after the end of the trial. Generalized estimating equations were used to compare these data, setting α = 0.05. Results: In intention-to-treat analysis, the medicated participants obtained a greater magnitude of decrease in total cholesterol (TC) (−3.41 to −25.89 mg.dl−1; p = 0.038), LDL (−5.58 to −25.18 mg.dl−1; p = 0.007) and TC/HDL ratio (−0.37 to −0.61; p = 0.022) when compared to the non-medicated participants, and this decrease was statistically significant only in the WR group. Conclusions: Statin use enhances the adaptations promoted by water-based physical training in CT, LDL levels, and CT/HDL ratio, and it is more pronounced after WR.


Subject(s)
Humans , Female , Aged , Cardiovascular Diseases , Dyslipidemias/drug therapy , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Cholesterol, HDL , Cholesterol, LDL
13.
Rev. habanera cienc. méd ; 20(4): e3598, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1289618

ABSTRACT

Introducción: Desde hace algunos años, se reporta en la literatura médica una posible asociación entre la periodontitis con otras enfermedades y condiciones sistémicas. Objetivo: Determinar la relación entre la periodontitis con las dislipidemia, obesidad o ambas. Material y Método: Estudio analítico transversal. Del universo de 9 350 individuos residentes en el municipio Plaza de la Revolución en edades entre 35 y 70 años, ambos sexos; se seleccionó una muestra probabilística utilizando el esquema muestreo aleatorio simple de 1 200 individuos que otorgaron su consentimiento para participar. Debían presentar, en su historia clínica médica, resultados de análisis complementarios para detectar dislipidemia en los últimos seis meses y como mínimo seis dientes en boca. Las variables estudiadas fueron: periodontitis, dislipidemia, obesidad y presencia de dislipidemia y obesidad en el mismo individuo. Los sujetos se clasificaron en tres grupos: con presencia de dislipidemia, obesos y ambas entidades (dislipidemia+obesidad). Resultados: La variable más encontrada fue dislipidemia (73,0 por ciento), seguida de periodontitis (62,2 por ciento). La periodontitis se encontró con mayor frecuencia en individuos que presentaban dislipidemia (48,1 por ciento), los obesos presentaron en su mayoría periodontitis, en los sujetos que presentaron dislipidemia + obesidad, la periodontitis fue más frecuente que en los que no presentaban ambas entidades unidas. Conclusiones: La periodontitis se relacionó con la dislipidemia, obesidad y ambas unidas, no así con la obesidad, aunque fue más frecuente en estos últimos que en los no obesos(AU)


Introduction: A possible association between periodontitis and other diseases and systemic conditions has been reported by the medical literature for many years. Objective: To determine the relationship between periodontitis and dyslipidemia and obesity or both of them. Material and Methods: An analytical cross-sectional study was conducted. The universe consisted of 9 350 individuals between the ages of 35 and 70 years, of both sexes who live in Plaza de la Revolución Municipality. From this universe, a sample composed of 1 200 individuals who gave their consent to participate in the study was selected by simple random sampling method. Their clinical records should include the results of complementary tests to determine dyslipidemia in the last six months; also, they should have at least six teeth in the mouth. The variables studies included: periodontitis, dyslipidemia, obesity and the presence of dyslipidemia and obesity in the same individual. The subjects were divided into three groups: with dyslipidemia, obese and with both entities (dyslipidemia+obesity). Results: The most common variable found was dyslipidemia (73,0 percent), followed by periodontitis (62,2 percent). Periodontitis was more frequently found in individuals with dyslipidemia (48,1 percent), and the majority of obese subjects had periodontitis. Periodontitis was more frequent in individuals with dyslipidemia + obesity than in the ones that did not present both entities at the same time. Conclusions: Periodontitis was associated with dyslipidemia, obesity and with both entities at the same time, but it was not associated with obesity only. However, it was more frequent in obese subjects than in non-obese ones(AU)


Subject(s)
Simple Random Sampling , Dyslipidemias/complications , Obesity/complications , Medical Records , Cross-Sectional Studies , Chronic Periodontitis/complications
14.
Rev. colomb. cardiol ; 28(4): 366-373, jul.-ago. 2021. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1351934

ABSTRACT

Resumen La COVID-19 es una enfermedad infecciosa causada por el coronavirus del síndrome respiratorio agudo severo 2 (SARS-CoV-2) que tiene importantes manifestaciones sobre el sistema cardiovascular y respiratorio. Esta enfermedad, descrita en los primeros días de diciembre de 2019 en la ciudad de Wuhan, capital de la provincia de Hubei, en China, tuvo una rápida expansión mundial y fue declarada por la Organización Mundial de la Salud como pandemia el 11 de marzo de 2020. Tiene diferentes presentaciones clínicas, como neumonía, hipoxemia, falla renal, falla multisistémica, compromiso endotelial que lleva a lesiones trombóticas venosas y arteriales, y problemas cardiacos como insuficiencia cardiaca, miocarditis, arritmias e infarto de miocardio de los tipos 1 y 2. La mayoría de las personas presentan una enfermedad leve o no complicada (80%), y otras (20%) pueden desarrollar un cuadro grave con neumonía, síndrome de dificultad respiratoria, choque cardiogénico, trombosis y tormenta de citocinas (el 15% se manejan con oxigenoterapia y el 5% ameritan tratamiento en la unidad de cuidados intensivos). La mortalidad está relacionada con la edad y con la comorbilidad (hipertensión arterial, diabetes mellitus, enfermedades respiratorias, enfermedades cardiacas en general, enfermedades renales y obesidad). El objetivo de esta revisión narrativa es describir las alteraciones metabólicas y la relación de la diabetes mellitus, la obesidad, el síndrome metabólico y la dislipidemia con la morbilidad y la mortalidad vinculadas a la COVID-19.


Abstract COVID-19 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that has important manifestations on the cardiovascular system and respiratory. This disease described in the first days of December 2019 in the city of Wuhan, capital of the province of Hubei, China, with a rapid global expansion and declared by the World Health Organization as a pandemic on March 11, 2020, has different clinical presentations such as pneumonia, hypoxemia, kidney failure, multisystem failure, endothelial involvement leading to venous and arterial thrombotic lesions, and heart problems such as heart failure, myocarditis, arrhythmias, and type 1 and 2 myocardial infarction. Most people have a mild or uncomplicated disease (80%), and others (20%) may develop a severe case with pneumonia, respiratory distress syndrome, cardiogenic shock, thrombosis, and cytokine storm (15% are managed with oxygen therapy and 5% merit treatment in the intensive care unit). Mortality is related to age and comorbidity (high blood pressure, diabetes mellitus, respiratory diseases, heart diseases in general, kidney diseases, and obesity). The objective of this narrative review is to describe the metabolic alterations and the relationship between diabetes mellitus, obesity, metabolic syndrome, and dyslipidemia with the morbidity and mortality associated with COVID-19 infection.


Subject(s)
Humans , Respiratory System , Severe Acute Respiratory Syndrome , COVID-19 , Disease , Diabetes Mellitus , Dyslipidemias , Obesity
15.
Rev. cuba. pediatr ; 93(2): e1417, tab, fig
Article in Spanish | LILACS, CUMED | ID: biblio-1280364

ABSTRACT

Introducción: La asociación de asma y obesidad ha aumentado su prevalencia en los últimos años. Objetivos: Caracterizar a niños y adolescentes asmáticos con obesidad asociada. Métodos: Investigación descriptiva, transversal y prospectiva, 2017-2018, Servicio de Neumología, Hospital Pediátrico Universitario Centro Habana. Se evaluaron 43 pacientes asmáticos entre 5 y 18 años de edad con obesidad exógena asociada. Se exploraron edad, sexo, antecedentes familiares de asma y obesidad, severidad y grado de control del asma. Se realizaron estudios para evaluar el metabolismo lipídico y de los hidratos de carbono. Resultados: La distribución por edades fue similar (escolares, adolescencia temprana y tardía), predominó el sexo masculino en escolares: 11 de 16 (68,7 por ciento) y el femenino en la adolescencia tardía: 12 de 15 (80 por ciento). Se refirieron antecedentes familiares de obesidad en 5 (11,6 por ciento) y asma asociada a obesidad en 26 (60,5 por ciento); la mayoría presentaba asma persistente leve: 38 (88,4 por ciento), no controlados: 28 (65,1 por ciento) y parcialmente controlados 10 (23,3 por ciento). Dos pacientes presentaban intolerancia a los hidratos de carbono (4,7 por ciento), uno de ellos con resistencia a la insulina. La dislipidemia fue el trastorno metabólico más frecuente: colesterol sérico elevado en 23 (53,5 por ciento), LDLc alto en 13 (30,2 por ciento) y HDLc bajo en 10 (23,3 por ciento). Conclusiones: Los niños asmáticos con historia familiar de obesidad tienen alto riesgo de ser también obesos, lo cual puede dificultar el control del asma; son frecuentes en ellos las alteraciones metabólicas(AU)


Introduction: The association of asthma and obesity has increased its prevalence in recent years. Objectives: Characterize asthmatic children and adolescents with associated obesity. Methods: Descriptive, cross-sectional and prospective research, 2017 - 2018, Pneumology Service, Centro Habana University Pediatric Hospital. 43 asthmatic patients from 5 to 18 years old with associated exogenous obesity were assessed. Age, sex, family history of asthma and obesity, severity and degree of asthma control were studied. Studies were conducted to evaluate lipid and carbohydrate metabolism. Results: Age distribution was similar (schoolers, early and late adolescence), predominated male sex in schoolchildren (11 of 16 - 68.7 percent) and the female in late adolescence (12 of 15 -80 percent). Family history of obesity was reported in 5 patients (11.6 percent) and obesity-associated asthma in 26 (60.5 percent); most had mild persistent asthma (38 -88.4 percent) poorly controlled: 28 uncontrolled (65.1 percent) and 10 partially controlled (23.3 percent). Two patients had carbohydrate intolerance (4.7 percent), one of them with insulin resistance. Dyslipidemia was the most common metabolic disorder: serum cholesterol increased in 23 - 53.5 percent, high LDLc in 13 - 30.2 percent, and low HDLc in 10 - 23.3 percent. Conclusions: Asthmatic children with a family history of obesity are also at high risk of being obese, which can make difficult to control asthma; metabolic alterations are common in them(Au)


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Asthma , Age Distribution , Dyslipidemias , Carbohydrate Metabolism , Obesity
16.
Arch. latinoam. nutr ; 71(2): 85-93, jun. 2021. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1290813

ABSTRACT

Tradicionalmente se han utilizado algunos índices antropométricos para el diagnóstico de exceso de peso en niños y adolescentes que han mostrado algunas desventajas por lo que se han postulado otros indicadores. En ese sentido, se plantea estimar el nivel de asociación entre indicadores antropométricos y la presencia de dislipidemia en adolescentes y adultos jóvenes. Se realizó una investigación observacional, descriptiva y de corte transversal en 123 adolescentes (68,2% mujeres, edad promedio 14,5 años) y 122 adultos jóvenes (70,5% mujeres, edad promedio 21 años) de la ciudad de Caracas. Se calcularon Índices de Masa Corporal (IMC), Índice Cintura­Talla (ICT), Índice de Masa Corporal Abdominal (IMCA) e Índice de Masa Tri-Ponderal (IMT). Se obtuvo una muestra de sangre por punción venosa, en ayuno de 12 a 14 horas, a partir de la cual se cuantificó Colesterol Total, Lipoproteína de alta densidad y Triglicéridos. Se calculó la concentración de Lipoproteína de baja densidad por la fórmula de Friedewald, así como el índice LDL-C/HDL-C y el índice LogTg/HDL. Para el análisis e interpretación de los datos se utilizó estadística descriptiva univariante y multivariante. Los resultados revelaron que los índices antropométricos IMCA e IMT no mostraron mejor desempeño en predecir dislipidemia que los indicadores IMC, Circunferencia de Cintura (CC) e ICT en adolescentes y adultos jóvenes. Los indicadores antropométricos de adiposidad abdominal, CC e ICT, tendieron a presentar mayores OR, ABC, sensibilidad y especificidad independientemente del grupo de estudio. En general, la capacidad de los indicadores antropométricos evaluados en predecir la presencia de dislipidemia en adultos jóvenes fue adecuada, situación que no se presentó en los adolescentes(AU)


Traditionally, some anthropometric indices have been used for the diagnosis of excess weight in children and adolescents, which have shown some disadvantages for which other indicators have been postulated. In this sense, it is proposed to estimate the level of association between anthropometric indicators and the presence of dyslipidemia in adolescents and young adults. An observational, descriptive cross-sectional investigation was carried out in 123 adolescents (68,2% women, media age 14,5 years) and 122 young adults (70,5% women, media age 21 years) from the city of Caracas. Body Mass Indices (BMI), Waist-Height Ratio (WHR), Abdominal Body Mass Index (BMAI) and Tri-Ponderal Mass Index (TMI) were calculated. A blood sample was obtained by venipuncture, fasting for 12 to 14 hours, from which Total Cholesterol, High Density Lipoprotein and Triglycerides were quantified. The low-density lipoprotein concentration was calculated by the FriedEwald formula, as well as the LDL-C / HDL-C index and the LogTg / HDL index. Univariate and multivariate descriptive statistics were used for the analysis and interpretation of the data. The results revealed that the BMI and TMI anthropometric indices did not show better performance in predicting dyslipidemia than the BMI, Waist Circumference (WC) and WHR indicators in adolescents and young adults. The anthropometric indicators of abdominal adiposity, WC and WHR, tended to present higher OR, AUC, sensitivity and specificity regardless of the study group. In general, the capacity of the anthropometric indicators evaluated to predict the presence of dyslipidemia in young adults was adequate, a situation that did not occur in adolescents(AU)


Subject(s)
Humans , Animals , Male , Adolescent , Adult , Dyslipidemias/physiopathology , Waist Circumference , Waist-Height Ratio , Body Mass Index , Anthropometry , Obesity, Abdominal , Pediatric Obesity
17.
rev. cuid. (Bucaramanga. 2010) ; 12(2): e1678, mayo 1, 2021. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1341804

ABSTRACT

Abstract Introduction Metabolic Syndrome (MS) is currently considered a multi-factorial disease related to the asymptomatic, insidious, and deleterious inflammation that predisposes the individual to vulnerability by aggregating cardiovascular risk markers. Objective to analyze the factors associated with Metabolic Syndrome and Quality of Life (QOL) in adult users of a health unit. Material and Methods a cross-sectional study carried out with 108 adult users. Data collection was performed using a sociodemographic, clinical, and metabolic structured questionnaire and The Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) questionnaire. For the diagnosis of Metabolic Syndrome, the following criteria were used: increased abdominal circumference and arterial hypertension, diabetes, hypertriglyceridemia, and low HDL-cholesterol. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) 21.0 software. Results Metabolic Syndrome was identified in 88.0% of the adults. Of this total of users evaluated with the syndrome, 87.4% of the individuals were female; 71.7% had diabetes; 87.0% had arterial hypertension; sedentary lifestyle was identified in 53.7%. In the assessment of the BMI, overweight and obesity predominated in 68.4% and 24.9%, respectively. The domains with the lowest quality of life scores were General Health and Vitality. Conclusions The study made it possible to identify the Metabolic Syndrome in most of the adults evaluated. There was a low perception of quality of life among adults in all domains, except for physical aspects and vitality. Thus, there is a need for surveillance and health education for the studied population and improvement of their quality of life.


Resumen Introducción El Síndrome Metabólico (SM) se considera actualmente una enfermedad multifactorial relacionada con la inflamación asintomática, insidiosa y deletérea que predispone al individuo a la vulnerabilidad al agregar marcadores de riesgo cardiovascular. Objetivo analizar los factores asociados al síndrome metabólico y calidad de vida en adultos usuarios de una unidad de salud. Materiales y Métodos estudio transversal realizado con 108 usuarios adultos. La recogida de datos se realizó mediante un cuestionario sociodemográfico, clínico y metabólico, estructurado y mediante el cuestionario The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Para el diagnóstico de Síndrome Metabólico se utilizaron los siguientes criterios: aumento de la circunferencia abdominal e hipertensión arterial, diabetes, hipertrigliceridemia y colesterol HDL bajo. El análisis estadístico se realizó utilizando el software Statistical Package for Social Sciences (SPSS) 21.0. Resultados Se identificó síndrome metabólico en el 88,0% de los adultos. De este total de usuarios evaluados con el síndrome, el 87,4% de los individuos eran mujeres; 71,7% con diabetes; 87,0% tenía hipertensión arterial; Se identificó sedentarismo en 53,7%. En la valoración del IMC, predominaron el sobrepeso y la obesidad en 68,4% y 24,9%, respectivamente. Los dominios con las puntuaciones más bajas de calidad de vida fueron Salud general y Vitalidad. Conclusiones el estudio permitió identificar el Síndrome Metabólico en la mayoría de los adultos evaluados. Hubo una baja percepción de la calidad de vida entre los adultos en todos los dominios, excepto en los aspectos físicos y vitalidad. Por tanto, es necesaria la vigilancia y educación sanitaria de la población estudiada y la mejora de su calidad de vida.


Resumo Introdução A Síndrome Metabólica (SM) é atualmente considerada uma doença multifatorial relacionada à inflamação assintomática, insidiosa e deletéria que predispõe o indivíduo à vulnerabilidade por agregar marcadores de risco cardiovascular. Objetivo analisar os fatores associados à Síndrome Metabólica e a Qualidade de Vida (QV) em adultos, usuários de uma unidade de saúde. Materiales e Métodos estudo transversal realizado com 108 usuários, adultos. A coleta de dados foi realizada por meio de um questionário sociodemográfico, clínico e metabólico, estruturado e pelo questionário The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Para diagnóstico da Síndrome Metabólica utilizou-se como critérios: a circunferência abdominal aumentada e hipertensão arterial, Diabetes, hipertrigliceridemia e baixo HDL-colesterol. A análise estatística foi realizada com auxílio do software Statistical Package for Social Sciences (SPSS) 21.0. Resultados a Síndrome Metabólica foi identificada em 88,0% dos adultos. Desse total de usuários avaliados com a síndrome, 87,4% dos indivíduos eram do sexo feminino; 71,7% com Diabetes; 87,0% apresentaram hipertensão arterial; o sedentarismo foi identificado em 53,7%. Na avaliação do IMC preponderou o excesso de peso e a obesidade em 68,4% e 24,9%, respectivamente. Os domínios com menores escores da qualidade de vida foram Estado Geral de Saúde e Vitalidade. Conclusões o estudo possibilitou a identificação da Síndrome Metabólica na maioria dos adultos avaliados. Observou-se, em todos os domínios, uma baixa percepção da qualidade de vida entre os adultos, exceto nos aspectos físicos e vitalidade. Assim, faz-se necessária vigilância e educação em saúde para a população estudada e melhoria de sua qualidade de vida.


Subject(s)
Quality of Life , Metabolic Syndrome , Diabetes Mellitus , Dyslipidemias , Hypertension , Obesity
18.
rev. cuid. (Bucaramanga. 2010) ; 12(2): 1-12, mayo 1, 2021.
Article in English | LILACS, BDENF, COLNAL | ID: biblio-1343430

ABSTRACT

Introduction: Metabolic Syndrome (MS) is currently considered a multi-factorial disease related to the asymptomatic, insidious, and deleterious inflammation that predisposes the individual to vulnerability by aggregating cardiovascular risk markers. Objective: to analyze the factors associated with Metabolic Syndrome and Quality of Life (QOL) in adult users of a health unit. Material and Methods: a cross-sectional study carried out with 108 adult users. Data collection was performed using a sociodemographic, clinical, and metabolic structured questionnaire and The Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) questionnaire. For the diagnosis of Metabolic Syndrome, the following criteria were used: increased abdominal circumference and arterial hypertension, diabetes, hypertriglyceridemia, and low HDL-cholesterol. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) 21.0 software. Results: Metabolic Syndrome was identified in 88.0% of the adults. Of this total of users evaluated with the syndrome, 87.4% of the individuals were female; 71.7% had diabetes; 87.0% had arterial hypertension; sedentary lifestyle was identified in 53.7%. In the assessment of the BMI, overweight and obesity predominated in 68.4% and 24.9%, respectively. The domains with the lowest quality of life scores were General Health and Vitality. Conclusions: The study made it possible to identify the Metabolic Syndrome in most of the adults evaluated. There was a low perception of quality of life among adults in all domains, except for physical aspects and vitality. Thus, there is a need for surveillance and health education for the studied population and improvement of their quality of life.


Introducción: El Síndrome Metabólico (SM) se considera actualmente una enfermedad multifactorial relacionada con la inflamación asintomática, insidiosa y deletérea que predispone al individuo a la vulnerabilidad al agregar marcadores de riesgo cardiovascular. Objetivo: analizar los factores asociados al síndrome metabólico y calidad de vida en adultos usuarios de una unidad de salud. Materiales y Métodos: estudio transversal realizado con 108 usuarios adultos. La recogida de datos se realizó mediante un cuestionario sociodemográfico, clínico y metabólico, estructurado y mediante el cuestionario The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Para el diagnóstico de Síndrome Metabólico se utilizaron los siguientes criterios: aumento de la circunferencia abdominal e hipertensión arterial, diabetes, hipertrigliceridemia y colesterol HDL bajo. El análisis estadístico se realizó utilizando el software Statistical Package for Social Sciences (SPSS) 21.0. Resultados: Se identificó síndrome metabólico en el 88,0% de los adultos. De este total de usuarios evaluados con el síndrome, el 87,4% de los individuos eran mujeres; 71,7% con diabetes; 87,0% tenía hipertensión arterial; Se identificó sedentarismo en 53,7%. En la valoración del IMC, predominaron el sobrepeso y la obesidad en 68,4% y 24,9%, respectivamente. Los dominios con las puntuaciones más bajas de calidad de vida fueron Salud general y Vitalidad. Conclusiones: el estudio permitió identificar el Síndrome Metabólico en la mayoría de los adultos evaluados. Hubo una baja percepción de la calidad de vida entre los adultos en todos los dominios, excepto en los aspectos físicos y vitalidad. Por tanto, es necesaria la vigilancia y educación sanitaria de la población estudiada y la mejora de su calidad de vida.


Introdução: A Síndrome Metabólica (SM) é atualmente considerada uma doença multifatorial relacionada à inflamação assintomática, insidiosa e deletéria que predispõe o indivíduo à vulnerabilidade por agregar marcadores de risco cardiovascular. Objetivo: analisar os fatores associados à Síndrome Metabólica e a Qualidade de Vida (QV) em adultos, usuários de uma unidade de saúde. Materiales e Métodos: estudo transversal realizado com 108 usuários, adultos. A coleta de dados foi realizada por meio de um questionário sociodemográfico, clínico e metabólico, estruturado e pelo questionário The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Para diagnóstico da Síndrome Metabólica utilizou-se como critérios: a circunferência abdominal aumentada e hipertensão arterial, Diabetes, hipertrigliceridemia e baixo HDL-colesterol. A análise estatística foi realizada com auxílio do software Statistical Package for Social Sciences (SPSS) 21.0. Resultados: a Síndrome Metabólica foi identificada em 88,0% dos adultos. Desse total de usuários avaliados com a síndrome, 87,4% dos indivíduos eram do sexo feminino; 71,7% com Diabetes; 87,0% apresentaram hipertensão arterial; o sedentarismo foi identificado em 53,7%. Na avaliação do IMC preponderou o excesso de peso e a obesidade em 68,4% e 24,9%, respectivamente. Os domínios com menores escores da qualidade de vida foram Estado Geral de Saúde e Vitalidade. Conclusões: o estudo possibilitou a identificação da Síndrome Metabólica na maioria dos adultos avaliados. Observou-se, em todos os domínios, uma baixa percepção da qualidade de vida entre os adultos, exceto nos aspectos físicos e vitalidade. Assim, faz-se necessária vigilância e educação em saúde para a população estudada e melhoria de sua qualidade de vida.


Subject(s)
Humans , Male , Female , Quality of Life , Metabolic Syndrome , Diabetes Mellitus , Dyslipidemias , Hypertension , Obesity
19.
An. Fac. Cienc. Méd. (Asunción) ; 54(1): 61-66, 20210000.
Article in Spanish | LILACS | ID: biblio-1178623

ABSTRACT

Introducción: Identificar factores de riesgo para pérdida de la sensibilidad protectora es fundamental para prevenir el Pie Diabético. Objetivos: Analizar los factores de riesgo asociados a la pérdida de la sensibilidad protectora en pacientes con diabetes mellitus y sus complicaciones. Materiales y métodos: diseño observacional, de casos y controles. Se incluyó pacientes de ambos sexos, con diabetes mellitus; ≥ 18 años, a quienes se realizó el Test de monofilamento en la Unidad Multidisciplinaria Hospital de Clínicas, de enero 2014 a julio 2019. Factores de riesgo considerados: edad, años de diabetes mellitus, Hba1c, HTA, dislipidemia; se tuvo en cuenta las complicaciones: retinopatía, enfermedad arterial periférica = ITB <0,9 derecho e izquierdo, enfermedad renal= ClCr <60 ml/min/m2 (MDRD), amputaciones (mayores y menores). Resultados: De 100 pacientes; 33% con pérdida de la sensibilidad protectora; edad 59±9,7 años; 55% masculino. Factores de riesgo: edad: 57,7±1,0 años sin pérdida de la sensibilidad protectora y 61,2±9 años con pérdida de la sensibilidad protectora, p=0.08; años de diabetes mellitus 9,4±8,4 vs 11,5± 8,7 p=0,20; HbA1C 8,8± 2,7% vs 9,1±2% p=0,50; HTA 63,5% vs 75,6% p=0,20; dislipidemias 75,9% vs 57,69%, p=0,09; complicaciones con pérdida de la sensibilidad protectora: retinopatía 88% vs 57,5% OR=1,67, p=0,02. ClCr 84±40,3 ml/min vs 90,9±30,4, p=0,40. Enfermedad arterial periférica derecha 27,78% vs 11,1% OR=0,1, p=0,10; enfermedad arterial periférica izquierda 20% vs 7 15,5% OR=1 p=0,60; amputación 17,5% vs 7,9% OR=2,01, p=0,06. Conclusión: con pérdida de la sensibilidad protectora: la edad, años de diabetes mellitus fueron mayores. HTA fue más frecuente y Hba1c más elevada; nefropatía, enfermedad arterial periférica y amputación con mayor frecuencia, todas no significativas. La retinopatía fue más frecuente en forma significativa.


Introduction: Identifying risk factors for loss of protective sensitivity is essential to prevent Diabetic Foot. Objectives: To analyze the risk factors associated with the loss of protective sensitivity in patients with diabetes mellitus and its complications. Materials and methods: observational, case-control design. Patients of both sexes were included, with diabetes mellitus; ≥ 18 years, who underwent the Monofilament Test in the Multidisciplinary Unit Hospital de Clínicas, from January 2014 to July 2019. Risk factors considered: age, years of diabetes mellitus, Hba1c, HT, dyslipidemia; Complications were taken into account: retinopathy, peripheral arterial disease = ABI <0.9 right and left, kidney disease = CrCl <60 ml / min / m2 (MDRD), amputations (major and minor). Results: Of 100 patients; 33% with loss of protective sensitivity; age 59 ± 9.7 years; 55% male. Risk factors: age: 57.7 ± 1.0 years without loss of protective sensitivity and 61.2 ± 9 years with loss of protective sensitivity, p = 0.08; years of diabetes mellitus 9.4 ± 8.4 vs 11.5 ± 8.7 p = 0.20; HbA1C 8.8 ± 2.7% vs 9.1 ± 2% p = 0.50; HTN 63.5% vs 75.6% p = 0.20; dyslipidemias 75.9% vs 57.69%, p = 0.09; complications with loss of protective sensitivity: retinopathy 88% vs 57.5% OR = 1.67, p = 0.02. CrCl 84 ± 40.3 ml / min vs 90.9 ± 30.4, p = 0.40. Right peripheral arterial disease 27.78% vs 11.1% OR = 0.1, p = 0.10; left peripheral arterial disease 20% vs 7 15.5% OR = 1 p = 0.60; 17.5% amputation vs 7.9% OR = 2.01, p = 0.06. Conclusion: with loss of protective sensitivity: age, years of diabetes mellitus were older. HBP was more frequent and Hba1c higher; nephropathy, peripheral arterial disease and amputation with greater frequency, all not significant. Retinopathy was significantly more frequent.


Subject(s)
Diabetic Foot , Diabetes Mellitus , Dyslipidemias , Peripheral Arterial Disease , Amputation , Risk Factors , Kidney Diseases
20.
Rev. cuba. endocrinol ; 32(1): e256, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1289383

ABSTRACT

Introducción: Se ha descrito una probable asociación entre la presencia de osteopenia/osteoporosis y el riesgo incrementado de cardiopatía isquémica. Objetivo: Determinar la posible asociación entre la presencia de síndrome coronario agudo y la densidad mineral ósea disminuida, así como la relación de ambas condiciones con algunos factores de riesgo cardiovascular y variables de la esfera reproductiva en mujeres en etapa de climaterio. Método: Se realizó un estudio transversal descriptivo con 72 mujeres (34 con síndrome coronario agudo y 38 sin síndrome coronario agudo), que fueron seleccionadas de bases de datos del Instituto de Cardiología y Cirugía Cardiovascular. La densidad mineral ósea se determinó mediante absorciometría dual de rayos X en columna lumbar. Las pruebas Chi cuadrado y U de Mann Whitney permitieron evaluar la posible relación entre variables. Resultados: El 55,9 por ciento de las pacientes con síndrome coronario agudo y el 60,5 por ciento de las mujeres sin síndrome coronario agudo tenían densidad mineral ósea disminuida. En las mujeres con densidad mineral ósea disminuida (n=42): 81 por ciento presentaron obesidad abdominal, 78,6 por ciento dislipoproteinemia, 83,3 por ciento hipertensión arterial y 76,2 por ciento refirieron el antecedente familiar de cardiopatía isquémica. Conclusiones: En las mujeres en etapa de climaterio estudiadas no se demostró asociación entre la presencia de síndrome coronario agudo y la densidad mineral ósea disminuida. Tampoco existió relación entre la presencia de síndrome coronario agudo y la densidad mineral ósea disminuida con factores de riesgo cardiovascular, ni con las variables de la esfera reproductiva(AU)


Introduction: A probable association has been described between the presence of osteopenia/osteoporosis and the increased risk of ischemic heart disease. Objective: To determine the possible association between the presence of acute coronary syndrome and decreased bone mineral density, as well as the relationship of both conditions with some cardiovascular risk factors and variables of the reproductive sphere in women during the climacteric stage. Method: A descriptive and cross-sectional study was carried out with 72 women (34 with acute coronary syndrome and 38 without acute coronary syndrome), who were selected from databases of the Institute of Cardiology and Cardiovascular Surgery. Bone mineral density was determined by dual lumbar spine X-ray absorptiometry. The chi-square and Mann Whitney U tests allowed to evaluate the possible relationship between variables. Results: 55.9 percent of the patients with acute coronary syndrome and 60.5 percent of the women without acute coronary syndrome had decreased bone mineral density. Among women with decreased bone mineral density (n=42), 81 percent had abdominal obesity, 78.6 percent had dyslipoproteinemia, 83.3 percent had arterial hypertension, and 76.2 percent had a family history of ischemic heart disease. Conclusions: In the women in the climacteric stage studied, no association was shown between the presence of acute coronary syndrome and decreased bone mineral density. There was no relationship either between the presence of acute coronary syndrome and decreased bone mineral density with cardiovascular risk factors, or with variables in the reproductive sphere(AU)


Subject(s)
Humans , Female , Adult , Middle Aged , Osteoporosis/diagnosis , Bone Diseases, Metabolic/etiology , Climacteric , Heart Disease Risk Factors , Bone Density , Epidemiology, Descriptive , Cross-Sectional Studies , Dyslipidemias/pathology , Acute Coronary Syndrome/pathology
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