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1.
J. Hum. Growth Dev. (Impr.) ; 30(2): 197-208, May-Aug. 2020. ilus, tab
Article in English | LILACS (Americas), INDEXPSI | ID: biblio-1114928

ABSTRACT

BACKGROUNG: People with Down syndrome (DS) may present changes in the lipid profile. The objective of this research was to collect data from the literature on the lipid profile and the effect of exercise on this variable of people with DS. Five databases were searched (MedLine, Lilacs, EBSCO Host, Web of Science and PsycInfo) using terms related to the research objectives. At the end of the searches, 15 articles were included in the review. Five studies verified changes in the lipid profile and high incidence of dyslipidemias, with the most frequent changes being low HDL and elevated triglycerides. Two studies investigated the effect of intervention with exercise and counseling for health-friendly practices and found improvement mainly in HDL after the intervention period. Thus, the lipid profile should be investigated in people with DS and the practice of physical exercises can be used to control these variables


INTRODUÇÃO: Pessoas com síndrome de Down (SD) podem apresentar alterações no perfil lipídico. O objetivo desta pesquisa foi reunir dados da literatura sobre o perfil lipídico e o efeito do exercício sobre essa variável de pessoas com SD. Cinco bases de dados foram pesquisadas (MedLine, Lilacs, EBSCO Host, Web of Science e PsycInfo), utilizando termos relacionados aos objetivos da pesquisa. Ao final das buscas, 15 artigos foram incluídos na revisão. Cinco estudos verificaram alterações no perfil lipídico e incidência elevada de dislipidemias, sendo as alterações mais frequentes o baixo HDL e triglicérides elevados. Dois estudos investigaram o efeito de intervenção com exercícios físicos e com aconselhamento para práticas benéficas para saúde e verificaram melhora principalmente no HDL depois do período de intervenção. Assim, o perfil lipídico deve ser investigado em pessoas com SD e a prática de exercícios físicos pode ser utilizada para o controle destas variáveis


Subject(s)
Humans , Male , Female , Triglycerides , Exercise , Cholesterol , Down Syndrome , Dyslipidemias
2.
Int. j. morphol ; 38(2): 392-399, abr. 2020. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1056453

ABSTRACT

The exercise could play a central role to the fat management and glucose metabolism what can be a critical role in the health status of diabetic people, but the high intense exercise remains with controversial data about their effects. To identify the effect of the multimodal high-intensity interval training on body composition, lipid profile, and glucose metabolism in elderly diabetics. Methods: Elderly diabetic individuals (n = 48) were randomly divided in a Sedentary Control (SC) group, a Moderate-Intensity Continuous Training (MICT) group, and a High-Intensity Interval Training (HIIT) group. MICT and HITT were conducted over 60 days, 3x per week, with 40 minutes of exercise. Blood was collected prior to intervention, at four, and at eight weeks subsequently to assess glucose metabolism and lipid profiles. Body composition was determined before and after the intervention period. To verify the normality Kolmogorov-Smirnov statistical test was performed, followed by student "t" test or two-way ANOVA with Bonferroni's post hoc test with significance of 5 % the Cohen's f test to indicate the magnitude of the differences. HIIT significantly lowered cholesterol and triglyceride levels, and significantly lowered blood glucose and glycosylated haemoglobin levels (p<0.05). MICT and HIIT significantly increased levels of high-density lipoprotein, decreased total body mass and body mass index. HIIT resulted in significantly smaller waist circumferences, waist-to-hip ratios, and weight-to-height ratios over 60 days of training. HIIT is more effective than MICT for improving lipid and glycaemic profiles, decreasing body fat, and improving fat distribution elderly diabetics.


El ejercicio podría desempeñar un papel central en el manejo de la grasa y el metabolismo de la glucosa, lo que puede ser un papel crítico en el estado de salud de las personas diabéticas, pero el ejercicio intenso intenso sigue teniendo datos controvertidos sobre sus efectos. El objetivo del estudio fue identificar el efecto del entrenamiento multimodal de intervalos de alta intensidad sobre la composición corporal, el perfil lipídico y el metabolismo de la glucosa en diabéticos de edad avanzada. Los individuos diabéticos de edad avanzada (n = 48) se dividieron aleatoriamente en un grupo de control sedentario (SC), un grupo de entrenamiento continuo de intensidad moderada (MICT) y un grupo de entrenamiento de intervalos de alta intensidad (HIIT). MICT y HITT se realizaron durante 60 días, 3 veces por semana, con 40 minutos de ejercicio. Se recogió sangre antes de la intervención, a las cuatro y a las ocho semanas posteriormente para evaluar el metabolismo de la glucosa y los perfiles de lípidos. La composición corporal se determinó antes y después del período de intervención. Para verificar la normalidad se realizó la prueba estadística de Kolmogorov-Smirnov, seguida de la prueba "t" de Student o ANOVA de dos vías con la prueba post hoc de Bonferroni con una significancia del 5 % de la prueba f de Cohen, indicando las diferencias. HIIT redujo significativamente los niveles de colesterol y triglicéridos, además de reducir de manera importante los niveles de glucosa en la sangre y la hemoglobina glicosilada (p <0.05). MICT y HIIT aumentaron significativamente los niveles de lipoproteína de alta densidad, disminuyeron la masa corporal total y el índice de masa corporal. HIIT resultó en circunferencias de cintura significativamente más pequeñas, relaciones cintura-cadera y relaciones peso-altura durante 60 días de entrenamiento. HIIT es más efectivo que MICT para mejorar los perfiles de lípidos y glucémicos, disminuir la grasa corporal y mejorar la distribución de grasa en los diabéticos de edad avanzada.


Subject(s)
Humans , Male , Female , Aged , Body Composition , Diabetes Mellitus , High-Intensity Interval Training/methods , Glycated Hemoglobin A , Exercise , Body Mass Index , Longitudinal Studies , Dyslipidemias/metabolism , Glucose/metabolism
3.
Rev. argent. dermatol ; 101(1): 21-30, mar. 2020. graf
Article in Spanish | LILACS (Americas) | ID: biblio-1092406

ABSTRACT

Resumen El Granuloma Anular (GA) es una dermatosis inflamatoria crónica, benigna, auto limitada, de etiología desconocida. Existen numerosas variantes clínicas dentro de las cuales se encuentra la perforante, de presentación inusual. La histopatología más característica de GA, cuenta con la presencia de histiocitos epitelioides en empalizada alrededor de áreas de degeneración focal de fibras de colágeno con depósitos de mucina. La variedad perforante evidencia eliminación transepidérmica de fibras de colágeno. Se presenta un paciente de 72 años de edad, diabético, dislipémico, con lesiones pruriginosas en dorso de ambas manos, con el diagnóstico de granuloma anular perforante. Realizó tratamiento con clobetasol tópico, más antihistamínicos por vía oral, quedando una cicatriz atrófica.


Abstract Granuloma annulare is a chronic, benign, self-limiting, inflammatory dermatosis of unknown etiology. There are numerous clinical variants within which is the perforating, unusual presentation. The most histopathology characteristic of GA is the presence of palisading epithelioid histiocytes around areas of focal degeneration of collagen with mucin deposits. The perforating variety evidences transepidermal elimination of collagen tissue. A 72 years-old, diabetes, dyslipidemic patient is presented with pruritic lessions on the dorsum of both hands, with the diagnosis of perforating granuloma annulare. I perform medical treatment with topical clobetasol, leaving an atrophic scar.


Subject(s)
Humans , Male , Aged , Granuloma Annulare/diagnosis , Granuloma Annulare/pathology , Granuloma Annulare/therapy , Diabetes Mellitus, Type 2/complications , Diagnosis, Differential , Dyslipidemias/complications
4.
Demetra (Rio J.) ; 15(1): e44290, jan.- mar.2020. tab
Article in English, Portuguese | LILACS (Americas) | ID: biblio-1096258

ABSTRACT

Objetivo: Investigar a evolução de parâmetros bioquímicos em mulheres privadas de liberdade. Métodos: Estudo observacional, prospectivo, envolvendo a totalidade da população feminina encarcerada em regime fechado de Natal, Rio Grande do Norte, Brasil. Foram comparados exames bioquímicos (glicemia de jejum, colesterol total, triglicerídeos, LDL-c, HDL-c, não-HDL-c), realizados nos anos de 2012 (n=180) e 2015 (n=89), por meio dos testes de Mann-Whitney, Wilcoxon e Qui-quadrado. Resultados: Verificou-se elevada prevalência de HDL-c baixo, de Não HDL-c elevado e de hipertrigliceridemia isolada em ambos os anos do estudo. Após três anos de encarceramento, a coorte de detentas apresentou elevação nas concentrações da glicemia de jejum (62,2mg/dL para 87,9mg/dL, p<0,001), colesterol total (163,3mg/dL para 184,9mg/dL, p=0,007), não-HDL-c (120,8mg/dL para 138,2mg/dL, p=0,023), triglicerídeos (96,7mg/dL para 150,2mg/dL, p=0,024) e HDL-c (42,5mg/dL para 46,7mg/dL, p=0,012). Conclusão: Durante o encarceramento, ocorreram importantes alterações bioquímicas que podem favorecer o desenvolvimento e agravamento de doenças crônicas não transmissíveis, evidenciando a necessidade de intensificar as ações de saúde no ambiente prisional. (AU)


Objective: To investigate the evolution of biochemical parameters in incarcerated women. Methods: An observational prospective study involving the entire incarcerated female population in a closed regime in Natal, Rio Grande do Norte, Brazil. Biochemical tests (fasting blood glucose, total cholesterol, triglycerides, LDL-c, HDL-c, non-HDL-c) performed in the years 2012 (n = 180) and 2015 (n = 89) were compared using the Mann-Whitney, Wilcoxon and Chi-squared tests. Results: There was a high prevalence of low HDL-c, high Non-HDL-c and isolated hypertriglyceridemia in both years of the study. After three years of incarceration, the cohort of inmates showed an increase in fasting blood glucose concentrations (62.2mg/dL to 87.9mg/dL, p<0.001), total cholesterol (163.3mg/dL to 184.9mg/dL, p = 0.007), non-HDL-c (120.8mg/dL to 138.2mg/dL, p = 0.023), triglycerides (96.7mg/dL to 150.2mg/dL, p = 0.024) and HDL-c (42.5mg/dL to 46.7mg/dL, p = 0.012). Conclusion: Important biochemical changes occurred during incarceration which may favor development and worsening of chronic non-communicable diseases, highlighting the need to intensify health actions in the prison environment. (AU)


Subject(s)
Humans , Female , Nutrition for Vulnerable Groups , Women's Health , Dyslipidemias , Prisoners , Women , Diabetes Mellitus
5.
Int. j. morphol ; 38(1): 129-134, Feb. 2020. tab, graf
Article in English | LILACS (Americas) | ID: biblio-1056410

ABSTRACT

Menopause complications such as cardiovascular and bone diseases represent a major public health concern. We sought to determine whether a high-fat diet (HFD) can augment ovariectomy-induced bone resorption in a rat model of menopause possibly via the upregulation of the inflammatory biomarkers and dyslipidemia. Rats were either ovariectomized and fed a standard laboratory chow (model group) or were ovariectomized and fed with a HFD for 15 weeks before being sacrificed. Ovariectomy significantly (p<0.05) increased body weight, dyslipidemia, insulin resistance, pro-inflammatory cytokines tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6), and biomarker of bone resorption, nuclear factor-kB (NF-kB), which were augmented by feeding animals with a HFD. This was confirmed through immunohistochemical study, where ovariectomy induced expression of p65/NF-kB protein in tibia bone sections of the model group, which were augmented by HFD. HFD augments ovariectomy-induced bone resorption through increased inflammatory biomarkers and NF-kB in rats.


Las complicaciones de la menopausia, como las enfermedades cardiovasculares y óseas, representan un importante problema de salud pública. Intentamos determinar si una dieta alta en grasas (HFD) puede aumentar la resorción ósea inducida por ovariectomía en un modelo de menopausia en ratas, a través de la regulación positiva de los biomarcadores inflamatorios y la dislipidemia. Las ratas fueron ovariectomizadas y alimentadas con una comida estándar de laboratorio (grupo modelo) o fueron ovariectomizadas y alimentadas con un HFD durante 15 semanas antes de ser sacrificadas. La ovariectomía aumentó significativamente (p <0,05) el peso corporal, dislipidemia, resistencia a la insulina, citocinas proinflamatorias, factor de necrosis tumoral a (TNF-α) e interleucina-6 (IL-6), y el biomarcador de resorción ósea, factor nuclear-kB (NF-kB), que se aumentaron alimentando animales con un HFD. Esto se confirmó a través del estudio inmunohistoquímico, donde la ovariectomía indujo la expresión de la proteína p65 / NF-kB en secciones de hueso de tibia del grupo modelo, que fueron aumentadas por HFD. HFD aumenta la resorción ósea inducida por ovariectomía a través del aumento de biomarcadores inflamatorios y NF-kB en ratas.


Subject(s)
Animals , Female , Rats , Bone Resorption/pathology , Diet, High-Fat/adverse effects , Triglycerides/analysis , Bone Resorption/etiology , Insulin Resistance , Menopause , Ovariectomy/adverse effects , Rats, Wistar , Disease Models, Animal , Dyslipidemias/complications
6.
Int. j. morphol ; 38(1): 215-221, Feb. 2020. graf
Article in English | LILACS (Americas) | ID: biblio-1056424

ABSTRACT

The potential inhibitory effect of the insulin mimicking agent, vanadium on type 2 diabetes mellitus (T2DM)induced alterations to the aorta ultrastructure associated with the suppression of dyslipedima and biomarkers of inflammation has not been investigated before. Therefore, we tested whether vanadium can protect against aortic injury induced secondary to T2DM possibly via the inhibition of blood lipid and inflammatory biomarkers. T2DM was induced in rats by a high-fat diet and streptozotocin (50 mg/ kg), and the treatment group started vanadium treatment five days post diabetic induction and continued until being sacrificed at week 10. Using light and electron microscopy examinations, we observed in the model group substantial damage to the aorta tissue such as damaged endothelium, degenerative cellular changes with vacuolated cytoplasm and thickened internal elastic lamina that were substantially ameliorated by vanadium. Administration of vanadium to diabetic rats also significantly (p<0.05) reduced blood levels of glucose, hyperlipidemia and biomarkers of inflammation (TNF-a, IL-6). We conclude that vanadium protects against T2DM-induced aortic ultrastructural damage in rats, which is associated with the inhibition of blood sugar and lipid and inflammatory biomarkers.


El potencial efecto inhibidor del agente imitador de la insulina, el vanadio en las alteraciones inducidas por la diabetes mellitus tipo 2 (DM2) en la ultraestructura de la aorta, asociada con la supresión de dislipidemia y los biomarcadores de inflamación no se ha investigado anteriormente. El objetivo fue estudiar las propiedades del vanadio para proteger contra la lesión aórtica inducida a la DM2, a través de la inhibición de los lípidos sanguíneos y los biomarcadores inflamatorios. La DM2 fue inducida en ratas con una dieta alta en grasas y estreptozotocina (50 mg / kg), y el grupo de tratamiento fue sometido a un régimen continuo con vanadio, cinco días después de la inducción diabética hasta ser sacrificadas en la semana 10. Se utilizaron exámenes de luz y microscopía electrónica en el grupo modelo y se observó un daño sustancial al tejido de la aorta, como también en el endotelio; los cambios celulares degenerativos con citoplasma vacuolado y lámina elástica interna engrosada mejoró sustancialmente con vanadio. La administración de vanadio a ratas diabéticas también redujo significativamente (p <0,05) los niveles sanguíneos de la glucosa, hiperlipidemia y los biomarcadores de inflamación (TNFa, IL-6). En conclusión, el vanadio protege contra el daño ultraestructural aórtico inducido por T2DM en ratas, que es asociado con la inhibición del azúcar en la sangre y los biomarcadores de lípidos y de inflamatorios.


Subject(s)
Animals , Male , Rats , Aorta/drug effects , Vanadium/administration & dosage , Diabetes Mellitus, Type 2/complications , Aorta/injuries , Aorta/ultrastructure , Aortic Diseases/etiology , Vanadium/pharmacology , Rats, Sprague-Dawley , Microscopy, Electron, Transmission , Disease Models, Animal , Dyslipidemias/drug therapy , Inflammation/drug therapy
7.
Nursing (Säo Paulo) ; 23(261)fev.2020.
Article in Portuguese | LILACS (Americas), BDENF | ID: biblio-1095578

ABSTRACT

Objetivo: analisar os padrões de simultaneidade da síndrome metabólica e os fatores sociodemográficos associados em quilombolas baianos. Métodos: Na amostra representativa de 850 adultos quilombolas, os componentes da síndrome metabólica foram definidos conforme o critério Joint Interim Statement. A razão entre a prevalência observada e a esperada determinaram as simultaneidades aumentadas. A regressão de Poisson com variância robusta testou as associações da maior simultaneidade e as variáveis sociodemográficas. Resultados: Metade das combinações da síndrome metabólica apresentaram prevalência observada maior que prevalência esperada. A hipertrigliceridemia foi o componente mais presente nas simultaneidades aumentadas. Após análise múltipla situação laboral e escolaridade permaneceram associadas (p<0,05) à maior simultaneidade. Conclusão: Ocorreu alta presença de simultaneidades aumentas em adultos quilombolas, tendo a hipertrigliceridemia como elemento mais recorrente. Além disso, a maior simultaneidade se associou trabalho remunerado e <5 anos de escolarização.(AU)


Objective: To analyze the simultaneity patterns of the metabolic syndrome and the associated sociodemographic factors in Bahian quilombolas. Methods: In the representative sample of 850 quilombola adults, the components of the metabolic syndrome were defined according to the Joint Interim Statement criterion. The ratio between observed and expected prevalence determined the increased simultaneities. Poisson regression with robust variance tested the associations of greatest simultaneity and sociodemographic variables. Results: Half of the metabolic syndrome combinations had higher prevalence than expected prevalence. Hypertriglyceridemia was the most common component in the increased simultaneities. After multiple analysis, employment status and education remained associated (p <0.05) with greater simultaneity. Conclusion: There was a high presence of increased simultaneities in quilombola adults, with hypertriglyceridemia as the most recurrent element. In addition, the highest simultaneity was associated with paid work and <5 years of schooling.(AU)


Objetivo: analizar los patrones de simultaneidad del síndrome metabólico y los factores sociodemográficos asociados en las quilombolas de Bahía. Métodos: En la muestra representativa de 850 adultos de quilombola, los componentes del síndrome metabólico se definieron de acuerdo con el criterio de la Declaración Interina Conjunta. La relación entre la prevalencia observada y la esperada determinó el aumento de las simultaneidades. La regresión de Poisson con varianza robusta probó las asociaciones de mayor simultaneidad y variables sociodemográficas. Resultados: La mitad de las combinaciones de síndrome metabólico tuvieron una prevalencia más alta que la esperada. La hipertrigliceridemia fue el componente más común en el aumento de las simultaneidades. Después de múltiples análisis, la situación laboral y la educación permanecieron asociadas (p <0.05) con una mayor simultaneidad. Conclusión: Hubo una alta presencia de simultaneidades aumentadas en adultos de quilombola, con hipertrigliceridemia como el elemento más recurrente. Además, la mayor simultaneidad se asoció con el trabajo remunerado y <5 años de escolaridad.(AU)


Subject(s)
Humans , Health Surveys , Social Indicators , Metabolic Syndrome , African Continental Ancestry Group , Socioeconomic Factors , Dyslipidemias
8.
Article in English | WPRIM (Western Pacific) | ID: wprim-816626

ABSTRACT

Korea is currently an aged society and is on the cusp of becoming a superaged society in a few years. The health burden of cardiovascular diseases increases with age, and the increasing prevalence of cardiovascular risk factors, such as obesity, hypertension, diabetes mellitus, and dyslipidemia, may be linked to increased population-level cardiovascular risk. In 2018, the prevalence of obesity in Korea was 35.7% (men, 45.4%; women, 26.5%) according to the Obesity Fact Sheet 2019, based on National Health Insurance Corporation medical checkup data. In 2016, the prevalence of diabetes was 14.4% in Koreans older than 30 years according to the Diabetes Fact Sheet published by the Korean Diabetes Association, based on data from the Korean National Health and Nutrition Examination Survey. The prevalence of hypertension in the total population of Korea in 2018 was 28.3% according to the Korean Hypertension Fact Sheet produced by the Korean Society of Hypertension. Lastly, the prevalence of dyslipidemia in 2018 was 40.5% according to the Dyslipidemia Fact Sheet published by the Korean Society of Lipid and Atherosclerosis. In this article, I would like to review the prevalence and current management of cardiovascular risk factors in Korea according to the fact sheets released by various associations.


Subject(s)
Adult , Atherosclerosis , Cardiovascular Diseases , Diabetes Mellitus , Dyslipidemias , Female , Humans , Hypertension , Korea , National Health Programs , Nutrition Surveys , Obesity , Prevalence , Risk Factors
9.
Article in English | WPRIM (Western Pacific) | ID: wprim-816621

ABSTRACT

BACKGROUND: We investigated associations between perirenal fat thickness and atherosclerotic calcification in six different vascular beds.METHODS: Using a community-based cohort (n=3,919), perirenal fat thickness was estimated from computed tomography scans. It was classified as Q1 (the lowest quartile) to Q4 (the highest quartile) in each sex. Calcification in the carotid arteries, coronary arteries, thoracic aorta, abdominal aorta, iliac arteries, and renal arteries was evaluated.RESULTS: Perirenal fat thickness was associated with older age (P<0.01) and a higher prevalence of obesity, hypertension, and dyslipidemia (P<0.01 for all). Perirenal fat thickness was independently associated with renal arterial calcification even after adjustment for age, sex, body mass index, hypertension, dyslipidemia, smoking history, and family history of heart diseases in first-degree relatives (odds ratio [OR] per quartile of perirenal fat thickness, 1.25; 95% confidence interval [CI], 1.09 to 1.44). Compared to Q1, the odds of renal arterial calcification in Q4 was about two times higher (OR, 2.05; 95% CI, 1.29 to 3.25). After adjustment for renal arterial calcification and atherosclerotic risk factors, the only other vascular bed where perirenal fat thickness showed a significant association with calcification was the abdominal aorta (OR, 1.11; 95% CI, 1.00 to 1.23; P=0.045).CONCLUSION: Perirenal fat thickness was independently associated with vascular calcification in the renal artery and abdominal aorta.


Subject(s)
Aorta, Abdominal , Aorta, Thoracic , Atherosclerosis , Body Mass Index , Carotid Arteries , Cohort Studies , Coronary Vessels , Dyslipidemias , Heart Diseases , Humans , Hypertension , Iliac Artery , Obesity , Prevalence , Renal Artery , Risk Factors , Smoke , Smoking , Vascular Calcification
10.
Article in Korean | WPRIM (Western Pacific) | ID: wprim-811450

ABSTRACT

PURPOSE: The main purpose of this study was to compare the relationships between physical activity (measured using an accelerometer vs. self-reported) and cardiovascular disease risk factors. Differences in accelerometry physical activity between 10-minute bouts and total bouts were also compared.METHODS: Data originated from the Korea National Health and Nutrition Examination Survey. Logistic regression was used to predict cardiovascular disease risk from physical activity levels.RESULTS: Self-reported physical activity could not significantly predict the odds of having cardiovascular risk. However, the insufficiently active group classified according to the total-bout physical activity had significantly greater odds of having hypertension or prehypertension (odds ratio [OR], 1.35; 95% confidence interval [95% CI], 1.00–1.82), diabetes mellitus (OR, 1.77; 95% CI, 1.01–3.19), and dyslipidemia (OR, 1.65; 95% CI, 1.17–2.36) than the highly active group. Regarding the 10-minute bout physical activity, the inactive group had significantly greater odds of having only hypertension or prehypertension (OR, 1.67; 95% CI, 1.02–2.76) than the highly active group.CONCLUSION: Total-bout physical activity measured using an accelerometer could significantly predict the cardiovascular disease risk compared to 10-minute bout physical activity. However, self-reported physical activity could not significantly predict the cardiovascular disease risk.


Subject(s)
Accelerometry , Cardiovascular Diseases , Diabetes Mellitus , Dyslipidemias , Hypertension , Korea , Logistic Models , Motor Activity , Nutrition Surveys , Prehypertension , Risk Assessment , Risk Factors , Self Report
11.
Article in English | WPRIM (Western Pacific) | ID: wprim-782506

ABSTRACT

BACKGROUND: To evaluate the macular pigment optical density (MPOD) with age in the Korean population using the Macular Pigment Screener II (MPSII®).METHODS: One hundred and twenty-six eyes were retrospectively reviewed. MPOD was measured using MPSII®, which uses a heterochromatic flicker photometry method, and the estimated values were analyzed. Spearman's correlation test was used to evaluate correlations between MPOD and age. The association between MPOD and age was determined using a simple linear regression analysis. MPODs among the four groups were compared via the post hoc analysis with Bonferroni correction, MPODs between the age-related macular degeneration (AMD) group and aged-matched healthy subjects were compared via the Mann-Whitney U test. Other risk factors for AMD were identified via a logistic regression analysis.RESULTS: Estimated MPOD decreased significantly with increasing age in the general population. In the simple regression analysis, a statistically significant linear regression model was observed, and the estimated values of MPOD decreased by −0.005 as age increased by 1 year. Aged (> 50 years) showed lower MPOD than younger (30–49 years) subjects. But, in the healthy population, the estimated MPOD values exhibited a decreasing trend with age, but there were no significant differences according to age, after excluding patients with AMD. MPOD was significantly lower in patients with AMD than in aged healthy controls. Furthermore, hypertension, dyslipidemia, and smoking were identified as risk factors for AMD.CONCLUSION: MPOD measured with MPSII® reflects the MP density in healthy individuals and patients with dry AMD. Aging was not significantly associated with low MPOD in healthy population, but the presence of dry AMD was significantly associated with low MPOD. Then, low MPOD may be a risk factor for development of dry AMD. Furthermore, routine screening with MPS II® for ages 50 and older is thought to help detect early low MPOD and identify individuals who should take supplements.


Subject(s)
Aging , Dyslipidemias , Healthy Volunteers , Humans , Hypertension , Linear Models , Logistic Models , Macular Degeneration , Macular Pigment , Mass Screening , Methods , Photometry , Retrospective Studies , Risk Factors , Smoke , Smoking
12.
Article in English | WPRIM (Western Pacific) | ID: wprim-811146

ABSTRACT

BACKGROUND: Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia.METHODS: This randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels ≥200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (OM3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment.RESULTS: After 8 weeks of treatment, the percent changes from baseline in TG (−29.8% vs. 3.6%, P<0.001) and non-HDL-C (−10.1% vs. 4.9%, P<0.001) levels were significantly greater in the ATOMEGA group (n=97) than in the atorvastatin group (n=103). Moreover, the proportion of total subjects reaching TG target of <200 mg/dL in the ATOMEGA group was significantly higher than that in the atorvastatin group (62.9% vs. 22.3%, P<0.001). The incidence of adverse events did not differ between the two groups.CONCLUSION: The addition of OM3-FAs to atorvastatin improved TG and non-HDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia.


Subject(s)
Adult , Atorvastatin , Cholesterol , Cholesterol, LDL , Dyslipidemias , Fasting , Fatty Acids, Omega-3 , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Hypertriglyceridemia , Incidence , Lipoproteins , Triglycerides
13.
Article in English | WPRIM (Western Pacific) | ID: wprim-811143

ABSTRACT

BACKGROUND: Diabetes mellitus is associated with an increased risk of dementia. We aimed to comprehensively analyze the incidence and risk factors for dementia and young-onset dementia (YOD) in diabetic patients in Korea using the National Health Insurance Service data.METHODS: Between January 1, 2009 and December 31, 2012, a total of 1,917,702 participants with diabetes were included and followed until the date of dementia diagnosis or until December 31, 2015. We evaluated the incidence and risk factors for all dementia, Alzheimer's disease (AD), and vascular dementia (VaD) by Cox proportional hazards analyses. We also compared the impact of risk factors on the occurrence of YOD and late-onset dementia (LOD).RESULTS: During an average of 5.1 years of follow-up, the incidence of all types of dementia, AD, or VaD was 9.5, 6.8, and 1.3/1,000 person-years, respectively, in participants with diabetes. YOD comprised 4.8% of all dementia occurrence, and the ratio of AD/VaD was 2.1 for YOD compared with 5.5 for LOD. Current smokers and subjects with lower income, plasma glucose levels, body mass index (BMI), and subjects with hypertension, dyslipidemia, vascular complications, depression, and insulin treatment developed dementia more frequently. Vascular risk factors such as smoking, hypertension, and previous cardiovascular diseases were more strongly associated with the development of VaD than AD. Low BMI and a history of stroke or depression had a stronger influence on the development of YOD than LOD.CONCLUSION: The optimal management of modifiable risk factors may be important for preventing dementia in subjects with diabetes mellitus.


Subject(s)
Alzheimer Disease , Blood Glucose , Body Mass Index , Cardiovascular Diseases , Dementia , Dementia, Vascular , Depression , Diabetes Mellitus , Diabetes Mellitus, Type 2 , Diagnosis , Dyslipidemias , Follow-Up Studies , Humans , Hypertension , Incidence , Insulin , Korea , National Health Programs , Risk Factors , Smoke , Smoking , Stroke
14.
Med. interna (Caracas) ; 36(1): 35-45, 2020. ilus, tab, graf
Article in Spanish | LILACS (Americas), LIVECS | ID: biblio-1103077

ABSTRACT

La obesidad constituye un esta- do subclínico de inflamación, que promueve complicaciones cardiovasculares. Objetivo: Establecer la relación entre la concentración de proteína C reactiva ultrasensible (PCRus) y el engrosamiento de la íntima media carotídea en obesos. Método: estudio transversal, descriptivo y comparativo. Se determinaron variables antropométricas, parámetros bioquímicos, concentración de PCRus, y gro- sor de íntima media carotídea (GIMC) en obesos normolipémicos y dislipidémicos. Resultados: se evaluaron 45 pacientes obesos normolipémicos y dislipidémicos, con una edad media de 36±9,23 años y 38,33±8,30 años respectivamente, sin diferencias significativas en peso, talla, circunferencia abdominal y presión arterial. La PCRus se encontró en 0,967±0,73mg/dl en el grupo normolipémi- co, y 1,328±0,75mg/dl, en el grupo dislipidémico, con significancia estadística (p=0,022) y una media de grosor de íntima media de 0,87±0,23mm y 0,95±0,20mm. Los pacientes con valores de PCRus ≥1mg/dl, presentaron un mayor peso, índice de masa corporal (IMC) y circunferencia abdo- minal. Se encontró una correlación de 0,361 entre el GIMC y PCRus, y en el grupo normolipémico, una correlación de 0,423 (p=0,004). Igualmente, se encontró una correlación de 0,336 entre el GIMC y la circunferencia abdominal en los normolipémicos. Conclusión: La PCRus ≥1mg/dl en pacientes obesos, se correlacionó con un mayor peso, el IMC y la circunferencia abdominal, así como aumento del GIMC y presencia de placas de ateroma. En pacientes obesos normolipémicos, se encontró correlación moderada entre el grosor de íntima media carotídea, con la PCRus y circunfe- rencia abdominal(AU)


Obesity is a condition of subclini- cal inflammation, which promotes cardiovascular complications. Objective: To establish the rela- tionship between the concentration of high sensitive C reactive protein (CPRhs) and carotid media- intima thickness in obese normolipidemic patients. Methods: crosssectional, descriptive and comparative study. Anthropometric variables, biochemi- cal parameters, CPRhs concentration, and carotid media-intima thickness (IMT) were determined in normolypemic and dyslipidemic obese patients. Results: 45 normolipidemic and dyslipidemic patients were evaluated, with an average age of 36±9,23 years and 38,33±8,30 years respectively, without significant differences in weight, height, abdominal circumference and blood pressure. The CPRhs was found in 0,967±0,73mg/dl in the normolipidemic group, and 1,328±0,75mg/dl in the dyslipidemic group, with statistical significance (p=0.022) and an average IMT of 0,87±0,23mm and 0,95±0,20mm respectively. Patients with CPRhs ≥1mg/dl values had higher weight, body mass index (BMI) and abdominal circumference. A correlation of 0,361 was found between the IMT and CPRhs, and in the normolipidemic group, a correlation of 0,423 (p=0.004). The correlation of 0,336 was found between IMT and abdominal circumference in normolipidemic patients. Conclusion: CPRhs ≥1mg/dl in obese patients, was correlated with increased weight, BMI and abdominal circumference, as well as increased IMT and presence of atherosclerosis plaques. In obese normolipidemic patients, a moderate correlation was found between carotid media-intima thickness with IMT and abdo- minal circumference, may suggest the use of these markers in primary atherosclerotic disease preven- tion in obese patients(AU)


Subject(s)
Humans , C-Reactive Protein , Cardiovascular Diseases , Carotid Intima-Media Thickness , Obesity/epidemiology , Abdominal Circumference , Dyslipidemias , Arterial Pressure
15.
Article in English | WPRIM (Western Pacific) | ID: wprim-786078

ABSTRACT

Like other bodily materials, lipids such as plasma triacylglycerol, cholesterols, and free fatty acids are in a dynamic state of constant turnover (i.e., synthesis, breakdown, oxidation, and/or conversion to other compounds) as essential processes for achieving dynamic homeostasis in the body. However, dysregulation of lipid turnover can lead to clinical conditions such as obesity, fatty liver disease, and dyslipidemia. Assessment of “snap-shot” information on lipid metabolism (e.g., tissue contents of lipids, abundance of mRNA and protein and/or signaling molecules) are often used in clinical and research settings, and can help to understand one's health and disease status. However, such “snapshots” do not provide critical information on dynamic nature of lipid metabolism, and therefore may miss “true” origin of the dysregulation implicated in related diseases. In this regard, stable isotope tracer methodology can provide the in vivo kinetic information of lipid metabolism. Combining with “static” information, knowledge of lipid kinetics can enable the acquisition of in depth understanding of lipid metabolism in relation to various health and disease status. This in turn facilitates the development of effective therapeutic approaches (e.g., exercise, nutrition, and/or drugs). In this review we will discuss 1) the importance of obtaining kinetic information for a better understanding of lipid metabolism, 2) basic principles of stable isotope tracer methodologies that enable exploration of “lipid kinetics” in vivo, and 3) quantification of some aspects of lipid kinetics in vivo with numerical examples.


Subject(s)
Cholesterol , Dyslipidemias , Fatty Acids, Nonesterified , Fatty Liver , Homeostasis , Kinetics , Lipid Metabolism , Mass Spectrometry , Obesity , Plasma , RNA, Messenger , Triglycerides
16.
Article in English | WPRIM (Western Pacific) | ID: wprim-786074

ABSTRACT

OBJECTIVE: Postmenopausal women show a more atherogenic lipid profile and elevated cardiovascular risk compared to premenopausal women. The aim of this study was to investigate the efficacy and safety of high-dose atorvastatin on the improvement of the blood lipid profile of postmenopausal women in Korea.METHODS: This study is a prospective, open-label, single-arm clinical trial that was conducted in 3 teaching hospitals. Postmenopausal women with a moderate-to-high cardiovascular risk, according to guidelines from the Korean Society of Lipid & Atherosclerosis, were enrolled. Participants were administered 20 mg of atorvastatin daily for the first 8 weeks, and if the targeted low-density lipoprotein cholesterol (LDL-C) level was not achieved, the dose was increased to 40 mg for the second 8 weeks. The primary endpoint was percentage change of LDL-C from baseline after 16 weeks of drug administration.RESULTS: Forty-four women were enrolled, 28 of whom (75.6%) had diabetes mellitus. By the end of treatment period (16 weeks) all patients had achieved LDL-C target levels, with 33 (94.2%) of the participants achieving it after only 8 weeks of administration. After 16 weeks, LDL-C decreased by 45.8±16.7% (p<0.001) from the baseline, and total cholesterol (33.2±10.9%; p<0.001), triglyceride (24.2±37.5%; p=0.001), and apolipoprotein B (34.9±15.6%; p<0.001) also significantly decreased. Blood glucose and liver enzyme levels slightly increased, but none of the participants developed serious adverse events that would cause them to prematurely withdraw from the clinical trial.CONCLUSION: 20 and 40 mg atorvastatin was effective and safe for treating dyslipidemia in postmenopausal Korean women with moderate-to-high cardiovascular risk.


Subject(s)
Apolipoproteins , Asian Continental Ancestry Group , Atherosclerosis , Atorvastatin , Blood Glucose , Cholesterol , Diabetes Mellitus , Dyslipidemias , Female , Hospitals, Teaching , Humans , Korea , Lipoproteins , Liver , Postmenopause , Prospective Studies , Triglycerides
17.
Article in English | WPRIM (Western Pacific) | ID: wprim-786070

ABSTRACT

OBJECTIVE: Previous studies have separately reported the contributions of dietary factors to the risk of cardiovascular disease (CVD) and its markers, including blood pressure (BP) and lipid profile. This study systematically reviewed the current evidence on this issue in the Korean population.METHODS: Sixty-two studies from PubMed and Embase were included in this meta-analysis. We performed a random-effects model to analyze pooled odds ratios (ORs) and hazard ratios (HRs) and their 95% confidence intervals (CIs) for the consumption of 14 food items, three macro- and eight micro-nutrients, two dietary patterns, and three dietary indices.RESULTS: An analysis of pooled effect sizes from at least four individual study populations showed significant associations between coffee consumption and CVD (OR/HR, 0.71; 95% CI, 0.52–0.97) and elevated/high triglycerides (TG) (OR, 0.84; 95% CI, 0.78–0.90), sugar-sweetened beverage intake and elevated BP (OR/HR, 1.20; 95% CI, 1.09–1.33), and milk and dairy intake and elevated/high TG and elevated high-density lipoprotein cholesterol (HDL-C) (OR/HR, 0.82; 95% CI, 0.76–0.89 for both). Carbohydrate consumption and the low-carbohydrate-diet score were consistently related to an approximately 25% risk reduction for elevated TG and HDL-C. A lower risk of elevated total cholesterol, but not low-density lipoprotein, was additionally observed for those with a higher low-carbohydrate-diet score. A healthy dietary pattern was only associated with a reduced risk of elevated TG in the Korea National Cancer Screenee Cohort (OR, 0.81; 95% CI, 0.67–0.98).CONCLUSION: This study showed that milk and dairy and coffee had protective effects for CVD and its risk factors, such as BP and lipid profile, while sugar-sweetened beverages exerted harmful effects.


Subject(s)
Asian Continental Ancestry Group , Beverages , Blood Pressure , Cardiovascular Diseases , Cholesterol , Coffee , Cohort Studies , Dyslipidemias , Humans , Hypertension , Korea , Lipoproteins , Milk , Odds Ratio , Risk Factors , Risk Reduction Behavior , Triglycerides
18.
Arch. argent. pediatr ; 117(6): S205-S242, dic. 2019. tab, graf
Article in Spanish | LILACS (Americas), BINACIS | ID: biblio-1051592

ABSTRACT

La enfermedad cardiovascular secundaria a aterosclerosis es la principal causa de morbimortalidad en la población adulta a nivel mundial. Aunque las manifestaciones clínicas de aterosclerosis (enfermedad coronaria, accidente cerebrovascular y arteriopatía periférica) son excepcionales en la población pediátrica, la presencia de factores de riesgo para enfermedad cardiovascular, así como la adquisición de hábitos que favorecen su desarrollo, se observan ya desde edades tempranas. En el presente documento, se elaboraron recomendaciones, con dos objetivos principales: prevenir la aparición de factores de riesgo para enfermedad cardiovascular (prevención primordial) y detectar y tratar los que favorecen el desarrollo de aterosclerosis clínica (prevención primaria). Si bien las recomendaciones están dirigidas a la población pediátrica, el objetivo del trabajo conjunto de la Sociedad Argentina de Pediatría y la Sociedad Argentina de Cardiología es asegurar un abordaje integral y consensuado de la prevencion cardiovascular a lo largo de toda la vida, incluso, desde antes de la concepción.


Cardiovascular disease secondary to atherosclerosis is the leading cause of morbimortality in the adult population worldwide. Although clinical manifestations of atherosclerosis (coronary heart disease, stroke and peripheral vascular disease) are extremely rare in the pediatric population, the presence of risk factors for cardiovascular disease and the development of health-behavior patterns that promote them are observed since early childhood.In this document, recommendations were developed addressing two main goals: prevention of the risk factors development for cardiovascular disease (primordial prevention) and early detection and treatment of the risk factors to prevent clinical atherosclerosis (primary prevention). Even though the recommendations are addressed to the pediatric population, the aim of the collaborative work between the Sociedad Argentina de Pediatría and the Sociedad Argentina de Cardiología is to ensure a comprehensive and consensual approach of lifetime cardiovascular prevention beginning even before conception.


Subject(s)
Humans , Infant , Child, Preschool , Child , Adolescent , Primary Prevention/methods , Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Exercise , Tobacco Use Disorder/prevention & control , Risk Factors , Substance-Related Disorders/prevention & control , Alcohol-Related Disorders/prevention & control , Metabolic Syndrome , Diabetes Mellitus, Type 2 , Dyslipidemias/diagnosis , Dyslipidemias/drug therapy , Overweight/prevention & control , Sedentary Behavior , Diet, Food, and Nutrition , Hypertension/diagnosis , Hypertension/prevention & control , Hypertension/therapy , Medical History Taking , Obesity/prevention & control
19.
Rev. cuba. angiol. cir. vasc ; 20(2): e386, jul.-dic. 2019. tab, graf
Article in Spanish | LILACS (Americas) | ID: biblio-1003856

ABSTRACT

Introducción: Los accidentes cerebrovasculares constituyen un problema de salud mundial con tendencia creciente; en la actualidad es la tercera causa de muerte. Objetivo: Describir la efectividad y durabilidad de la endarterectomía carotidea a largo plazo en la enfermedad carotidea extracraneal. Métodos: Se realizó un estudio descriptivo, ambispectivo en 44 pacientes sometidos a un total de 52 endarterectomías carotideas realizadas en el servicio de Angiología y Cirugía Vascular del Hospital Docente Clínico Quirúrgico Hermanos Ameijeiras. A todos se les realizó un seguimiento clínico con ultrasonografía doppler. El período de tiempo analizado fue de ocho años. Se tuvo en cuenta las variables: sexo, edad, factores de riesgo asociados, categoría clínica, localización topográfica de las lesiones, complicaciones tardías, tiempo de permeabilidad y resultados posquirúrgicos. Resultados: Predominó el sexo masculino (68,2 por ciento). Las lesiones carotideas asintomáticas y sintomáticas representaron el 50 por ciento respectivamente. El hábito de fumar y la dislipidemia fueron los factores de riesgo más frecuentes. Hubo predominio de las complicaciones tardías (55,8 por ciento) con relevancia de la restenosis carotidea (n= 21). El tiempo promedio de permeabilidad primaria del sector revascularizado fue de cinco años. El 86,5 por ciento de los pacientes seguidos a largo plazo mostraron resultados posquirúrgicos satisfactorios al no presentar eventos neurológicos isquémicos o lesiones carotideas con repercusión hemodinámica. Conclusiones: La endarterectomía carotidea es un procedimiento seguro con baja morbilidad y mortalidad perioperatorias que garantiza una reducción significativa en las tasas de enfermedad cerebrovascular isquémica en el seguimiento a largo plazo con baja incidencia de complicaciones vasculares y neurológicas tardías(AU)


Introduction: Cardiovascular events constitute a global health problem with a growing tendency. Nowadays, they represent the third cause of death. Objective: To describe the effectiveness and durability of long-term carotid endarterectomy in the extracranial carotid disease. Methods: A descriptive, ambispective study was conducted in 44 patients subjected to 52 carotid endarterectomies that were performed in the service of Angiology and Vascular Surgery of Hermanos Ameijeiras Teaching-Clinical- Surgical Hospital. A clinical follow-up was performed with Doppler ultrasonography to all the patients. The period analyzed was eight years. The variables considered were: sex, age, associated risk factors, clinical category, topographical localization of the lesions, late complications, time of permeability and postsurgical results. Results: Male sex predominated (68,2 percent). Asymptomatic and symptomatic carotid lesions represented 50 percent respectively. The smoking habit and dyslipidemia were the most common risk factors. There was predominance of late complications (55,8 percent) being notable the carotid restenosis (n = 21). The average time of primary permeability of the revascularized sector was five years. 86,5 percent of the patients followed in the long term showed satisfactory postsurgical results by not presenting ischemic neurological events or carotid lesions with hemodynamic impact. Conclusions: Carotid endarterectomy is a safe procedure with low morbidity and peri-operative mortality that ensures a significant reduction in ischemic cerebrovascular disease´s rates in long-term follow-up with low incidence of late vascular and neurological complications(AU)


Subject(s)
Humans , Male , Female , Risk Factors , Endarterectomy, Carotid/methods , Cerebrovascular Trauma/surgery , Dyslipidemias/prevention & control
20.
Actual. osteol ; 15(3): 214-224, Sept-Dic. 2019. graf, tab
Article in Spanish | LILACS (Americas) | ID: biblio-1116039

ABSTRACT

En la Argentina, las embarazadas presentan alta prevalencia (80%) de hipovitaminosis D y de sobrepeso u obesidad (27,4%). Ambas condiciones pueden aumentar la morbimortalidad materno-fetal. Bajos niveles de vitamina D se han relacionado con aumento del colesterol total, LDL, triglicéridos (Tg) y descenso de HDL. Objetivo: evaluar los niveles de 25-hidroxivitamina D (25OHD) y su relación con el perfil lipídico en pacientes embarazadas de alto riesgo. Materiales y métodos: estudio de corte transversal entre septiembre de 2016 y abril de 2017. Se excluyeron pacientes que recibieron suplementos de vitamina D, con disfunción tiroidea no compensada, malabsorción, insuficiencia cardíaca, renal o hepática y dislipidemia familiar. Niveles circulantes de 25OHD < 30 ng/ml se consideraron hipovitaminosis. Resultados: se evaluaron 86 embarazadas de 29,3 ± 7,1 años durante la semana 28 ± 6,5. El IMC pregestacional fue 28,3 ± 6,5 kg/m2 y la ganancia de peso 7 ± 4,3 kg. Perfil lipídico: colesterol total 240 ± 54 mg/dl; LDL 156 ± 54 mg/dl; HDL 66 ± 15 mg/dl; Tg 204 ± 80 mg/dl. La media de 25OHD fue de 23,8 ± 9 ng/ml, con una prevalencia de hipovitaminosis D de 77,9 %. Las pacientes con hipovitaminosis D presentaron mayores valores de colesterol total y LDL (p < 0,05), con tendencia no significativa a presentar mayores valores de Tg. Conclusión: en embarazadas de alto riesgo se observó una alta prevalencia de hipovitaminosis D, asociada con mayores concentraciones de colesterol total y LDL. (AU)


In Argentina, pregnant women have a high prevalence (80 %) of hypovitaminosis D and verweight/obesity (27.4%), conditions that can increase maternal-fetal morbidity and mortality. Low levels of 25-hydroxyvitamin D (25OHD) have been linked to an increase in total cholesterol, LDL cholesterol, triglycerides (TG) and a decrease in HDL cholesterol. Objective: to evaluate the levels of vitamin D and its relationship with the lipid profile in high risk pregnant patients. Materials and methods: cross-sectional study between September 2016 and April 2017. Patients who received vitamin D supplements or had non-compensated thyroid dysfunction, malabsorption, heart failure, renal or hepatic failure, or familial dyslipidemia were excluded. Hypovitaminosis D was defined as a circulating level of 25OHD < 30 ng/ml. Results: We assessed 86 women of 29.3 ± 7.1 years during pregnancy week 28 ± 6.5. Pre-gestational BMI was 28.3 ± 6.5 kg/m2. Their weight gain was 7 ± 4.3 kg. Lipid profile: total cholesterol 240 ± 54 mg/dl; LDL cholesterol 156 ± 54 mg/dl; HDL cholesterol 66 ± 15 mg/dL; TG 204 ± 80 mg/dl. The mean 25OHD level was 23.8 ± 9 ng/ml, with a 77.9 % prevalence of hypovitaminosis D. Patients with hypovitaminosis D had higher values of total cholesterol and LDL cholesterol (p<0.05), and a non-significant trend toward higher triglyceridemia. Conclusion: A high prevalence of hypovitaminosis D, associated with high total and LDL cholesterol was found in high risk pregnant women. (AU)


Subject(s)
Humans , Female , Pregnancy , Adult , Young Adult , Avitaminosis/metabolism , Vitamin D/metabolism , Pregnancy, High-Risk/metabolism , Argentina/epidemiology , Avitaminosis/blood , Avitaminosis/epidemiology , Vitamin D/analysis , Vitamin D/blood , Epidemiologic Studies , Body Mass Index , Cholesterol/analysis , Cholesterol/blood , Indicators of Morbidity and Mortality , Public Health/statistics & numerical data , Cross-Sectional Studies/statistics & numerical data , Diabetes, Gestational/metabolism , Pregnancy, High-Risk/blood , Dyslipidemias/metabolism , Overweight/metabolism , Obstetric Labor, Premature/metabolism , Cholesterol, LDL/analysis , Cholesterol, LDL/blood , Obesity/metabolism
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