Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 11 de 11
Filter
1.
Rev. Nutr. (Online) ; 29(5): 709-719, Sept.-Oct. 2016. tab, graf
Article in Portuguese | LILACS (Americas) | ID: biblio-830644

ABSTRACT

RESUMO Objetivo: Este trabalho avaliou a modulação da microbiota gastrointestinal, do perfil de ácidos orgânicos e de lipídeos em ratas Wistar ovariectomizadas, sendo que algumas receberam dieta suplementada com 6% de fruto-oligossacarídeos e inulina, a partir do produto a base de yacon, e outras não. Métodos: Analisou-se o peso do ceco, pH e ácidos orgânicos, microbiota do conteúdo cecal, colesterol total e frações. Resultados: No grupo que recebeu a dieta suplementada durante todo o experimento ocorreu modulação benéfica da microbiota intestinal em função da fermentação dos fruto-oligossacarídeos/inulina, bem como aumento do perfil de lactato (p<0,05) e do nível de lipoproteina alta densidade (p<0,05). Conclusão: Isso sugere que o hábito de consumo contínuo do yacon tem potencial para modular a microbiota intestinal, o perfil de ácidos orgânicos e para diminuir as dislipidemias.


ABSTRACT Objective: Fructans, a type of inulin present in yacon based products, can modulate microbiota and fatty acid profile, performing many beneficial roles. From this perspective, this study assessed the modulation of the gastrointestinal microbiota, organic acid profile, and lipid profile of ovariectomized Wistar rats fed or not a diet containing 6% fructooligosaccharides and inulin from a yacon based product. Methods: Cecum weight, pH, and organic acids, cecal content microbiota, total cholesterol, and fractions were analyzed. Results: The group fed the diet supplemented with fructooligosaccharides and inulin during the study period experienced beneficial modulation of their intestinal microbiota stemming from fructooligosaccharide/inulin fermentation and increased lactate profile (p<0.05) and high-density lipoprotein cholesterol (p<0.05). Conclusion: This suggests that regular yacon intake can potentially modulate the intestinal microbiota and organic acid profile, and reduce dyslipidemia.


Subject(s)
Animals , Guinea Pigs , Dyslipidemias/diet therapy , Oligosaccharides , Ovariectomy , Rats, Wistar , Fatty Acids , Prebiotics , Gastrointestinal Microbiome
3.
Rev. Soc. Bras. Med. Trop ; 46(6): 691-697, Nov-Dec/2013. tab
Article in English | LILACS (Americas) | ID: lil-698058

ABSTRACT

Introduction Although the initiation of highly active antiretroviral therapy (HAART) is accompanied by an attenuation of viral load, metabolic disorders characterized by hyperglycemia, dyslipidemia, and lipodystrophy are often observed in patients under this treatment. Certain foods, such as oat bran, soy protein, and flaxseed, have been shown to improve a patient's lipid profile despite possible increases in uricemia. Thus, a bioactive compound was formulated using these foods to help patients with HIV/AIDS control metabolic disorders resulting from HAART. Methods An uncontrolled before and after study was performed. The total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and uric acid before and after 3 months of consuming the formulation were compared in patients. The compound was formulated such that 40g (the recommended daily intake) contained approximately 10g of flaxseed, 20g of oat bran, and 10g of textured soy protein. Results The study population consisted of 139 patients, 31 of whom were included in the final analysis. There were no significant variations between the laboratory results obtained before and after consumption of the compound. Conclusions The regular consumption of the formulation together with individualized dietary guidance did not reduce lipid levels and did not contribute to an increase in uricemia in the study group. However, new studies with higher doses of the foods that compose the formulation should be encouraged to investigate whether these foods can positively influence the lipid profiles of these patients. .


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Acquired Immunodeficiency Syndrome/blood , Antiretroviral Therapy, Highly Active/adverse effects , Dyslipidemias/diet therapy , Food, Formulated , Lipids/blood , Uric Acid/blood , Avena , Dyslipidemias/chemically induced , Flax , Soybeans , Treatment Outcome
4.
Rev. nutr ; 26(2): 215-224, Mar.-Apr. 2013. graf, tab
Article in English | LILACS (Americas) | ID: lil-675994

ABSTRACT

OBJECTIVE: The aim of the present study was to evaluate the plasma lipid responses of dyslipidemic patients to nutritional counseling according to gender and age. METHODS: One-hundred and twenty nine dyslipidemic subjects comprised the study, 56 men and 73 women, aged 20 to 73 years, treated at the Dyslipidemia Outpatient Clinic of the Universidade Estadual de Campinas Clinic Hospital. The inclusion criteria established that no lipid-lowering medication had been used in the 30 days prior to and during the nutritional counseling. Blood samples were collected in the morning after a 12 hour fast. The participants were divided into groups according to gender and age (age <60 and > 60 years). The hypercholesterolemic patients were instructed to restrict saturated fats (<7%) and cholesterol (<200mg/day). Those presenting with high triglyceride levels (>300mg/dL) were asked to consume a low fat diet. Those with mixed hyperlipidemia were instructed to do both. Statistical analyses included the Wilcoxon, Mann-Whitney, Chi-square and Fisher's exact tests and Analysis of Covariance. RESULTS: After nutritional counseling, total cholesterol and triglycerides decreased by 16% and 36% in males, and by 12% and 26% in females, respectively, and Low Density Lipoprotein-cholesterol decreased by 12% in females. Only triglycerides decrease significantly. In the mixed hyperlipidemia group, the male and female triglyceride (-44% and -29%), Low Density Lipoprotein-cholesterol (+12% and -15%) and High Density Lipoprotein-cholesterol (+7% and -3%) levels differed significantly. Between the age groups, only triglyceride levels differed significantly, with adults experiencing the highest reductions (33%). CONCLUSION: Nutritional counseling effectively lowered plasma lipid and lipoprotein levels, reinforcing the benefits of dietary interventions for the treatment of dyslipidemia.


OBJETIVO: Avaliar a resposta do perfil lipídico e das lipoproteínas plasmáticas ao aconselhamento nutricional em indivíduos dislipidêmicos analisando as respostas entre os sexos e as faixas etárias. MÉTODOS: Participaram do estudo 129 indivíduos dislipidêmicos, 56 homens e 73 mulheres, de 20 a 73 anos, atendidos no Ambulatório de Dislipidemias do Hospital de Clínicas da Universidade Estadual de Campinas. Os critérios de exclusão foram: uso de medicação hipolipemiante no mínimo 30 dias antes da entrevista inicial e/ou durante o acompanhamento. Os participantes foram divididos em grupos segundo sexo e faixa etária (> 60 ou <60 anos). Orientou-se restrição de gorduras saturadas (<7%) e colesterol (<200mg/dia), além das gorduras totais (<20%) para valores de triglicérides >300mg/dL, nos hipercolesterolêmicos. Na hiperlipidemia mista utilizou-se ambas orientações. RESULTADOS: No sexo masculino, a redução de colesterol total e triglicerides foi de 16% e 36% respectivamente; no feminino 12%, 26%, e de 12% para a Lipoproteína de Baixa Densidade, com significância apenas para o triglicerides. Na hiperlipidemia mista, as diferenças entre os sexos foram significativas para triglicerides (-44% e -29%), Lipoproteína de Baixa Densidade (+12% e -15%) e Lipoproteína de Alta Densidade +7% e -3%), respectivamente. Entre as faixas etárias, a diferença foi significativa apenas para o triglicerides; os adultos apresentaram maiores reduções (33%). CONCLUSÃO: O aconselhamento nutricional mostrou-se efetivo na redução de lípides e lipoproteínas plasmáticos, reforçando os benefícios das intervenções dietéticas no tratamento das dislipidemias.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Dyslipidemias/diet therapy , Food and Nutrition Education , Nutrition Therapy/statistics & numerical data
5.
Rev. saúde pública ; 46(4): 737-746, Aug. 2012. tab
Article in Portuguese | LILACS (Americas) | ID: lil-646476

ABSTRACT

OBJETIVO: Analisar o efeito do tratamento nutricional sobre as alterações metabólicas provocadas pelo uso da terapia antirretroviral em adultos vivendo com HIV/aids. MÉTODOS: Revisão sistemática de literatura no PubMed, Lilacs e Cochrane, entre 1996 e 2010, do tipo ensaio clínico, controlado, randomizado, crossover, adultos, vivendo com HIV/aids em uso de terapia antirretroviral e sem doenças oportunistas. A intervenção de interesse foi suplementação nutricional via oral e/ou mudança de estilo de vida por tratamento dietoterápico específico: dislipidemia, resistência insulínica, lipodistrofia e hipertensão arterial sistêmica. A escala de Jadad foi utilizada para classificação qualitativa dos artigos. RESULTADOS: Foram localizados 385 artigos e sete foram incluídos. As intervenções utilizadas nesses estudos foram: dieta, dieta mais exercício físico, dieta mais suplemento e somente suplementos. Dislipidemia foi desfecho avaliado em todos os estudos. Os estudos que avaliaram suplementação com ômega 3 encontraram redução significativa dos triglicérides. Dieta específica mais suplementação de ômega 3 mostrou aumento de HDL-colesterol. Suplementação com nicotinato de cromo não teve efeito sobre a dislipidemia. Modificação de estilo de vida, incluindo dieta e atividade física, reduziu significativamente a circunferência da cintura, lipodistrofia e pressão arterial sistólica. CONCLUSÕES: A redução de triglicérides pela suplementação com ômega 3 foi a intervenção nutricional com maiores evidências científicas. A prescrição de dieta específica parece ser a intervenção mais adequada para aumentar HDL-colesterol. Não é possível fazer inferências sobre o tratamento nutricional do colesterol total, LDL-colesterol e resistência insulínica. Modificações no estilo de vida podem promover melhora da lipodistrofia e pressão arterial.


OBJECTIVE: To analyze the effect of nutritional treatment on metabolic changes caused by the use of antiretroviral therapy in adults with HIV/AIDS. METHODS: A systematic review of literature was conducted in the PubMed, Lilacs and Cochrane databases, between 1996 and 2010, including crossover and randomized controlled clinical trials performed in adults with HIV/AIDS using antiretroviral therapy and without opportunistic diseases. The intervention of interest was oral nutritional supplementation and/or a change in lifestyle due to specific dietary treatment: dyslipidemia, insulin resistance, lipodystrophy and systemic arterial hypertension. The Jadad scale was used for a qualitative classification of articles. RESULTS: A total of 385 articles were found, of which seven were included. The interventions used in these studies were as follows: diet, diet and physical exercises, diet and supplementation, and only supplementation. Dyslipidemia was the outcome assessed in all studies. Studies that assessed omega-3 supplementation found a significant reduction in triglycerides. The specific diet with omega-3 supplementation showed an increase in HDL-cholesterol. Chrome nicotinate supplementation did not have an effect on dyslipidemia. Changing one's lifestyle, including diet and physical activity, significantly reduced waist circumference, lipodystrophy and systolic blood pressure. CONCLUSIONS: Reduction in tryglicerides with omega-3 supplementation was the nutritional intervention with the strongest scientific evidence. Prescribing a specific diet appeared to be the most adequate intervention to increase HDL-cholesterol. Inferences could not be made about the nutritional treatment of total cholesterol, LDL-cholesterol and insulin resistance. Changes in lifestyle can promote an improvement in lipodystrophy and blood pressure.


OBJETIVO: Analizar el efecto del tratamiento nutricional sobre las alteraciones metabólicas provocadas por el uso de la terapia antirretroviral en adultos viviendo con VIH/Sida. MÉTODOS: Revisión sistemática de literatura en el PubMed, Lilacs y Cochrane, entre 1996 y 2010, del tipo ensayo clínico, controlado, aleatorio, crossover, adultos, viviendo con VIH/Sida en uso de terapia antirretroviral y sin enfermedades oportunistas. La intervención de interés fue suplementación nutricional vía oral y/o cambio de estilo de vida por tratamiento dietoterápico específico: dislipidemia, resistencia insulínica, lipodistrofia e hipertensión arterial sistémica. Se utilizó la escala de Jadad para clasificación cualitativa de los artículos. RESULTADOS: Se localizaron 385 artículos y siete fueron incluidos. Las intervenciones utilizadas en estos estudios fueron: dieta, dieta más ejercicio físico, dieta más suplemento y solamente suplementos. Dislipidemia fue el resultado evaluado en todos los estudios. Los estudios que evaluaron suplementación con omega 3 encontraron reducción significativa de los triglicéridos. La dieta específica más suplementación de omega 3 mostró aumento de HDL-colesterol. Suplementación con nicotinato de cromo no tuvo efecto sobre la dislipidemia. La modificación de estilo de vida, incluyendo dieta y actividad física, redujo significativamente la circunferencia de la cintura, lipodistrofia y presión arterial sistólica. CONCLUSIONES: La reducción de triglicéridos por la suplementación con omega 3 fue la intervención nutricional con mayores evidencias científicas. La prescripción de dieta específica parece ser la intervención más adecuada para aumentar HDL-colesterol. No es posible hacer inferencias sobre el tratamiento nutricional del colesterol total, LDL-colesterol y resistencia insulínica. Las modificaciones en el estilo de vida pueden promover mejoría de la lipodistrofia y presión arterial.


Subject(s)
Adult , Female , Humans , Male , Dietary Supplements , Dyslipidemias/diet therapy , HIV-Associated Lipodystrophy Syndrome/diet therapy , Antiretroviral Therapy, Highly Active/adverse effects , Clinical Trials as Topic , Cholesterol/blood , Exercise , /therapeutic use , Insulin Resistance , Life Style , Triglycerides/blood
6.
Rev. nutr ; 25(1): 35-44, jan.-fev. 2012. tab
Article in Portuguese | LILACS (Americas) | ID: lil-625199

ABSTRACT

OBJETIVO: Este estudo teve como objetivo avaliar o potencial hipolipidêmico do suco de camu-camu (Myrciaria dubia (Kunth) McVaugh) em ratos dislipidêmicos. MÉTODOS: Foram utilizados 72 ratos (Rattus norvegicus var. albinus) machos adultos da linhagem Wistar, com peso médio de 200g. O experimento foi dividido em duas fases: indução da dislipidemia e tratamento. Para indução da dislipidemia, todos os ratos receberam ração hiperlipídica (ração comercial adicionada a 10,0% de banha suína, 1,0% colesterol e 0,1% de ácido cólico) durante 21 dias. Na fase de tratamento, 40 ratos dislipidêmicos foram divididos aleatoriamente em 5 grupos (n=8), sendo 3 deles submetidos a tratamento com diferentes concentrações de suco de camu-camu (0,4mL.kg-1, 4,0mL.kg-1 e 10mL.kg-1) por 14 dias, 1 grupo submetido a tratamento com quercetina (10mL.kg-1) e 1 grupo hiperlidêmico. Estes dois últimos foram mantidos como parâmetro, ao lado do grupo basal. Para avaliar o efeito modulador do suco de camu-camu no perfil lipídico dos ratos, foram verificadas as concentrações de triacilgliceróis, colesterol total, lipoproteína de alta intensidade e lipoproteína de baixa intensidade, no plasma, assim como os níveis de colesterol fecal e hepático.RESULTADOS: As diferentes doses de suco de camu-camu e de quercetina apresentaram efeitos moduladores do perfil lipídico, ou seja, redução de triacilgliceróis, colesterol total, excreção fecal de colesterol, bem como redução do colesterol hepático. Salienta-se que os melhores resultados foram obtidos com a concentração de 10mL.kg-1. Resultado similar foi observado quanto ao consumo de ração. CONCLUSÃO: O suco de camu-camu apresentou efeito modulador do perfil lipídico em ratos dislipidêmicos. Os resultados poderão ser utilizados como referência em futuros trabalhos acerca desse fruto amazônico.


OBJECTIVE: This study evaluated the potential hypolipidemic effect of camu-camu juice (Myrciaria dubia (Kunth) McVaugh) in dyslipidemic rats. METHODS: Seventy-two adult male Wistar rats (Rattus norvegicus var. albinus Berkenhout) with an average weight of 200g were used. The experiment was divided into two phases: induction of dyslipidemia and treatment. Dyslipidemia was induced by a high-fat diet (commercial feed plus 10.0% lard, 1.0% cholesterol and 0.1% cholic acid) given to the animals for 21 days. In the treatment phase, 40 dyslipidemic rats were randomly divided into five groups (n=8). Of these, three were subjected to different treatments with camu-camu juice: 0.4mL.kg-1, 4.0mL.kg-1 and 10mL.kg-1 for 14 days. The other two groups were kept as parameters: a basal group (normolipidemic) and a hyperlipidemic group receiving 10mL.kg-1 of quercetin (standard treatment). The potential hypolipidemic effect of camu-camu juice was assessed by the following measurements: plasma lipoproteins (triacylglycerol, total cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol), fecal and liver cholesterol, and measurements of feed intake and body weight. RESULTS: All dosages of camu-camu juice were hypolipidemic, reducing triacylglycerol, total cholesterol, fecal cholesterol excretion and hepatic cholesterol. The best results were obtained by the 10 mL.kg-1 dosage of camu-camu juice. Rat body weight and food intake did not vary significantly during the treatment. CONCLUSION: Camu-camu juice has a hypolipidemic effect in dyslipidemic rats. These results can be used as reference for future studies on this Amazonian fruit.


Subject(s)
Animals , Male , Adult , Rats , Dyslipidemias/diet therapy , Dyslipidemias/metabolism , Quercetin , Rats, Wistar/metabolism
7.
Invest. clín ; 52(2): 140-149, jun. 2011. ilus, tab
Article in Spanish | LILACS (Americas) | ID: lil-664554

ABSTRACT

Hymenaea courbaril (Caesalpiniace), especie ampliamente diseminada en Venezuela, produce una goma clara y soluble en la semilla. El contenido de fibra dietética de la goma (60,7%) se usó como criterio para la formulación de un pan integral en la dieta para pacientes con dislipidemia. Se determinó la composición proximal del pan integral. La aceptabilidad del producto se evaluó por una prueba de comparación y por una escala hedónica. El diseño experimental, se hizo con una muestra de 30 voluntarios masculinos que presentaban dislipidemia. Se dividieron en dos grupos: el grupo A, se alimentó con una modificación de la dieta, que contenía un pan preparado con goma de H. courbaril, y el grupo B, recibió la dieta, sin la goma, con base en las recomendaciones de la Asociación Americana de Dietética (Control). Ambos grupos se mantuvieron en sus respectivas dietas durante 6 semanas. El perfil lipídico, se determinó en cada paciente, antes de iniciar la dieta y después del período señalado. El pan formulado, contenía 17,60% de proteínas; 1,19% de grasa y 0,97% de fibra cruda, de conformidad con lo establecido por las normas COVENIN. El Test de par de preferencia, demostró la mayor aceptación por el pan preparado con una concentración de goma al 7,0%, y un bajo contenido de grasa. Se produjo una disminución significativa en la concentración de triacilglicéridos y VLDL-colesterol en el grupo A. Estos hallazgos sugieren un posible uso de la goma de H. courbaril, como una modificación de la dieta, para pacientes con dislipidemia.


The seeds of Hymenaea courbaril (Caesalpiniace), a species widely disseminated in Venezuela, produce a clear and soluble gum. The dietetic fiber content (60.7%) of the gum was used as a good criterion for the formulation of integral bread in a diet for dyslipidemia patients. The proximal composition of the integral bread was determined. The product acceptability evaluation was done by a comparison test and by a hedonic scale. The experimental design was carried out with a total of 30 male volunteers with dyslipidemia. They were divided into two groups: Group A was fed with a modified diet, which included bread prepared with the H. courbaril gum; and Group B received the same diet without the gum, based on the American Dietetic Association recommendations. Both groups were maintained on their respective diets for six weeks. The lipid profile was determined in each patient, before starting the diets and after the specified period. The bread formula contained 17.60% protein, 1.19% fat and 0.97% crude fiber, in accordance with standards established by COVENIN. The paired preference test showed grater acceptance of the bread prepared with a gum concentration of 7% and low fat content. Significant decreases in the concentrations of triacylglycerol and VLDL-cholesterol were observed in Group A. These findings suggest a possible use of the H. courbaril gum, as a diet modifier for dyslipidemic patients.


Subject(s)
Adult , Humans , Male , Middle Aged , Bread , Cholesterol/blood , Dyslipidemias/blood , Dyslipidemias/diet therapy , Food, Formulated , Hymenaea , Triglycerides/blood , Severity of Illness Index
8.
Physis (Rio J.) ; 21(2): 417-436, 2011.
Article in Portuguese | LILACS (Americas) | ID: lil-596060

ABSTRACT

O presente artigo aborda os aspectos clínicos e socioeconômicos decorrentes da presença de dislipidemias em portadores de doenças cardiovasculares (DCV). Existem inúmeros estudos relacionados às DCV, uso de hipolipemiantes orais como as estatinas, e os aspectos econômicos envolvidos com impacto na área da saúde. Além de evidenciar a importância do tratamento das dislipidemias, o artigo busca demonstrar o ponto de vista farmacoeconômico, ou seja, dos custos gerados com o tratamento farmacológico desta patologia versus os custos decorrentes dos eventos cardiovasculares acometidos e suas consequências. Existe, portanto, relevante relação entre os impactos sociais decorrentes de incapacidade física e laborativa, aposentadorias precoces, entre outros custos importantes que poderiam ser evitados com uma análise econômica abrangente e eficiente realizada nos serviços de saúde do Brasil. Neste contexto, é enfatizada a importância da análise conjunta dos aspectos clínicos e socioeconômicos das dislipidemias que poderiam influenciar nas decisões das autoridades de saúde no momento da elaboração de protocolos clínicos de tratamentos farmacológicos a serem implementados no SUS.


This paper discusses the clinical and socioeconomic factors arising from the presence of dyslipidemia in patients with cardiovascular disease (CVD). There are numerous studies related to CVD, oral use of statins as statins, and the economics aspects involved with an impact on health. In addition to demonstrating the importance of the treatment of dyslipidemia, the paper shows the pharmacoeconomic viewpoint, i.e. costs generated by the pharmacological treatment of this disease versus the costs of cardiovascular events and their consequences. There is therefore relevant relationship between the social impacts arising from physical disability and work, early retirements, among other important costs that could be avoided with a comprehensive economic analysis and efficient health services in Brazil. In this context, we emphasize the importance of joint analysis of the clinical and socioeconomic aspects of dyslipidemia that could influence the decisions of health authorities at the time of preparation of clinical protocols of pharmacological treatments to be implemented within the SUS.


Subject(s)
Humans , Male , Female , Diagnosis , Dyslipidemias/diet therapy , Dyslipidemias/prevention & control , Cardiovascular Diseases/diagnosis , Cardiovascular Diseases/pathology , Critical Pathways/economics , Socioeconomic Factors , Unified Health System/economics , Brazil/epidemiology , Brazil/ethnology , Economics, Pharmaceutical , Hyperlipidemias/complications , Hyperlipidemias/diet therapy , Hyperlipidemias/prevention & control , Hypertriglyceridemia/prevention & control , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Primary Prevention/economics , Secondary Prevention
9.
Rev. nutr ; 22(5): 707-715, set.-out. 2009. tab, ilus
Article in Portuguese | LILACS (Americas) | ID: lil-536872

ABSTRACT

OBJETIVO: Investigar os efeitos do exercício de natação intermitente em relação ao exercício contínuo e ao sedentarismo, em ratos Wistar, após o desenvolvimento de obesidade exógena pela administração de uma dieta hiperlipídica palatável sobre: evolução do peso corporal, ingestão alimentar, adiposidade, percentual de gordura dos tecidos e perfil lipídico. MÉTODOS: Foram utilizados ratos adultos, mantidos em gaiolas individuais, com livre acesso a água e comida. O protocolo experimental incluiu: 1) desenvolvimento da obesidade exógena (3 semanas), os animais foram divididos em: P: sedentários alimentados com dieta padrão Primor® (n=8) e H: sedentários alimentados com dieta hiperlipídica (n=32); 2) tratamentos (8 semanas subseqüentes), os animais (n=24) passaram a receber dieta padrão e foram divididos em: sedentário; treinado contínuo e treinado intermitente. Treinamentos (5x semana): Contínuo (90 minutos/dia) e Intermitente (3x30min/dia). Os animais foram submetidos à eutanásia (3 e 8 semanas), sendo coletados os tecidos adiposos, o fígado e o sangue. Foram determinados a adiposidade e o percentual de gordura dos tecidos adiposos e do fígado, o ganho de peso corporal, o consumo alimentar e o perfil lipídico. RESULTADOS: A dieta hiperlipídica aumentou a adiposidade, o percentual de gordura acumulada no fígado e desenvolveu dislipidemias. A troca de dieta e os dois tipos de treinamento foram capazes de reverter o quadro de obesidade exógena. Contudo, o exercício intermitente foi mais eficiente na redução da adiposidade e de ganho de peso. CONCLUSÃO: Associados à dieta balanceada, os treinamentos aplicados neste estudo poderiam ser utilizados como estratégia no controle de peso e de dislipidemias, tanto em modelos experimentais quanto em seres humanos.


OBJECTIVE: The objective was to look into the effects of intermittent swimming against continuous exercise and inactivity in Wistar rats after they developed exogenous obesity though the consumption of a palatable fat-rich diet. The following was investigated: evolution of body weight, food intake, adiposity, fat percentage in tissues and lipid profile. METHODS: Adult rats were kept in individual cages with free access to food and water. The experimental protocol included: 1) development of exogenous obesity (3 weeks). The animals were divided into S - inactive animals fed the standard Primor® diet (n=8) and HF - inactive animals fed a high-fat diet (n=32); 2) Treatment (the 8 following weeks) - the animals (n=24) were given the standard diet and divided into an inactive group, a continuous training group and an intermittent training group. Training occurred 5 times per week and was either continuous (90 minutes per day) or intermittent (3 times 30 minutes per day). The animals were killed at 3 and 8 weeks and the fat tissues, the liver and the blood were collected. Adiposity, fat percentage of the fat tissues and liver, gain of body weight, food consumption and lipid profile were determined. RESULTS: The high-fat diet increased adiposity, percentage of fat in the liver, and induced dyslipidemias. Diet change and the two types of training were capable of reducing exogenous obesity. However, intermittent exercise was more efficient in reducing adiposity and preventing weight gain. CONCLUSION: When associated with a balanced diet, the trainings used in this study can be used as a strategy to control weight and dyslipidemias, both in experimental models and in human beings.


Subject(s)
Animals , Male , Adult , Rats , Dyslipidemias/diet therapy , Swimming/physiology , Obesity/chemically induced , Rats, Wistar
10.
Braz. j. med. biol. res ; 42(6): 487-493, June 2009. ilus, tab
Article in English | LILACS (Americas) | ID: lil-512759

ABSTRACT

We investigated the effect of the -278A>C polymorphism in the CYP7A1 gene on the response of plasma lipids to a reduced-fat diet for 6 to 8 weeks in a group of 82 dyslipidemic males with a mean age of 46.0 ± 11.7 years. Individuals who presented at least one high alteration in total cholesterol, low-density lipoprotein cholesterol or triglyceride values were considered to be dyslipidemic. Exclusion criteria were secondary dyslipidemia due to diabetes mellitus, renal, liver, or thyroid disease. None of the subjects were using lipid-lowering medication. Baseline and follow-up lipid concentrations were measured. The genotypes were determined by the digestion of PCR products with the BsaI restriction endonuclease. There were statistically significant reductions in plasma total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations after dietary intervention. The minor allele C has a frequency of 43 percent. Carriers of the C allele had significantly lower triglyceride concentrations (P = 0.02) than AA homozygotes. After adjustment of covariates, subjects with the AC and CC genotypes showed a greater reduction in triglyceride concentrations compared to subjects with the AA genotype. Multiple linear regression analyses showed that the AC and CC CYP7A1 genotypes accounted for 5.2 and 6.2 percent of triglyceride concentration during follow-up and adjusted percent of change of triglyceride concentration, respectively. The present study provides evidence that -278A>C polymorphism in the CYP7A1 gene can modify triglyceride concentrations in response to a reduced fat diet in a dyslipidemic male population. This gene represents a potential locus for a nutrigenetic directed approach.


Subject(s)
Adult , Humans , Male , Middle Aged , /genetics , Diet, Fat-Restricted , Dyslipidemias/enzymology , Polymorphism, Genetic/genetics , Triglycerides/blood , Body Mass Index , Dyslipidemias/blood , Dyslipidemias/diet therapy , Gene Frequency , Genotype , Lipids/blood , Promoter Regions, Genetic , Prospective Studies
11.
In. Isosaki, Mitsue; Cardoso, Elisabeth; Oliveira, Aparecida de. Manual de dietoterapia e avaliação nutricional: serviço de nutrição e dietética do Instituto do Coração - HCFMUSP. São Paulo, Atheneu, 2; 2009. p.11-22.
Monography in Portuguese | LILACS (Americas) | ID: lil-527302
SELECTION OF CITATIONS
SEARCH DETAIL