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1.
Rev. cuba. angiol. cir. vasc ; 20(2): e386, jul.-dic. 2019. tab, graf
Article in Spanish | LILACS (Americas) | ID: biblio-1003856

ABSTRACT

Introducción: Los accidentes cerebrovasculares constituyen un problema de salud mundial con tendencia creciente; en la actualidad es la tercera causa de muerte. Objetivo: Describir la efectividad y durabilidad de la endarterectomía carotidea a largo plazo en la enfermedad carotidea extracraneal. Métodos: Se realizó un estudio descriptivo, ambispectivo en 44 pacientes sometidos a un total de 52 endarterectomías carotideas realizadas en el servicio de Angiología y Cirugía Vascular del Hospital Docente Clínico Quirúrgico Hermanos Ameijeiras. A todos se les realizó un seguimiento clínico con ultrasonografía doppler. El período de tiempo analizado fue de ocho años. Se tuvo en cuenta las variables: sexo, edad, factores de riesgo asociados, categoría clínica, localización topográfica de las lesiones, complicaciones tardías, tiempo de permeabilidad y resultados posquirúrgicos. Resultados: Predominó el sexo masculino (68,2 por ciento). Las lesiones carotideas asintomáticas y sintomáticas representaron el 50 por ciento respectivamente. El hábito de fumar y la dislipidemia fueron los factores de riesgo más frecuentes. Hubo predominio de las complicaciones tardías (55,8 por ciento) con relevancia de la restenosis carotidea (n= 21). El tiempo promedio de permeabilidad primaria del sector revascularizado fue de cinco años. El 86,5 por ciento de los pacientes seguidos a largo plazo mostraron resultados posquirúrgicos satisfactorios al no presentar eventos neurológicos isquémicos o lesiones carotideas con repercusión hemodinámica. Conclusiones: La endarterectomía carotidea es un procedimiento seguro con baja morbilidad y mortalidad perioperatorias que garantiza una reducción significativa en las tasas de enfermedad cerebrovascular isquémica en el seguimiento a largo plazo con baja incidencia de complicaciones vasculares y neurológicas tardías(AU)


Introduction: Cardiovascular events constitute a global health problem with a growing tendency. Nowadays, they represent the third cause of death. Objective: To describe the effectiveness and durability of long-term carotid endarterectomy in the extracranial carotid disease. Methods: A descriptive, ambispective study was conducted in 44 patients subjected to 52 carotid endarterectomies that were performed in the service of Angiology and Vascular Surgery of Hermanos Ameijeiras Teaching-Clinical- Surgical Hospital. A clinical follow-up was performed with Doppler ultrasonography to all the patients. The period analyzed was eight years. The variables considered were: sex, age, associated risk factors, clinical category, topographical localization of the lesions, late complications, time of permeability and postsurgical results. Results: Male sex predominated (68,2 percent). Asymptomatic and symptomatic carotid lesions represented 50 percent respectively. The smoking habit and dyslipidemia were the most common risk factors. There was predominance of late complications (55,8 percent) being notable the carotid restenosis (n = 21). The average time of primary permeability of the revascularized sector was five years. 86,5 percent of the patients followed in the long term showed satisfactory postsurgical results by not presenting ischemic neurological events or carotid lesions with hemodynamic impact. Conclusions: Carotid endarterectomy is a safe procedure with low morbidity and peri-operative mortality that ensures a significant reduction in ischemic cerebrovascular disease´s rates in long-term follow-up with low incidence of late vascular and neurological complications(AU)


Subject(s)
Humans , Male , Female , Risk Factors , Endarterectomy, Carotid/methods , Cerebrovascular Trauma/surgery , Dyslipidemias/prevention & control
2.
Rev. cuba. pediatr ; 90(2): 306-312, abr.-jun. 2018. tab
Article in Spanish | LILACS (Americas) | ID: biblio-901490

ABSTRACT

Introducción: una alimentación muy selectiva y poco variada durante la primera infancia, puede modificar seriamente los índices de riesgo cardiovascular, ante lo cual, la detección de la alteración lipídica es de suma importancia para promover e implementar el cambio de hábitos. Caso clínico: se presenta una niña de 6 años con una dieta a base de alimentos industriales, a quien se le realizó un perfil lipídico, por considerar que la alimentación tan limitada que consumía era un factor de riesgo aterogénico. Esto permitió diagnosticar una marcada disminución del HDL-colesterol, hipertrigliceridemia y franca alteración de los índices de riesgo. Discusión: existe una relación directa entre la hipertrigliceridemia y el consumo de azúcares simples, presentes en las golosinas, postres o gaseosas. Además, las grasas saturadas e industriales (trans) son responsables de la disminución del colesterol HDL. Llamó la atención la contundencia que ejerció la alteración del laboratorio, sobre el accionar de los padres. Luego de 6 meses de poner en práctica las indicaciones, los valores y los índices de riesgo se normalizaron. Conclusiones: se destaca la importancia de realizar un perfil lipídico en niños mayores de 2 años cuando se detecta el consumo de una dieta aterogénica, dado que el descenso de colesterol HDL tiene relación directa con la alimentación y el estilo de vida. Un valor inferior a 45 mg/dL es un factor de riesgo que puede ser modificado(AU)


Introduction: a very selective and little varied diet during early childhood can seriously modify the cardiovascular risk indexes, and because of that the detection of lipid alteration is very important to promote and implement the change of habits. Clinical case: a 6-year-old girl was presented with a diet based on industrial foods. A lipid profile was made considering that the very limited diet she consumed was an atherogenic risk factor. This allowed diagnosing a marked decrease in HDL-cholesterol, hypertriglyceridemia and real alteration in the risk indexes. Discussion: there is a direct relation among hypertriglyceridemia and the consumption of simple sugars, which are present in sweets, desserts or sodas. In addition, saturated and industrial (trans) fats are responsible for lowering HDL cholesterol. It was significant the impact of the alteration in the laboratory results in the actions taken by the parents. After 6 months of putting the indications into practice, the values and risk indexes were normalized. Conclusions: it is highlighted the importance of performing a lipid profile in children older than 2 years when the consumption of an atherogenic diet is detected, since the decrease in HDL cholesterol is directly related to diet and lifestyle. A value below 45 mg/dL is a risk factor that can be modified(AU)


Subject(s)
Humans , Female , Child , Dietary Sugars/adverse effects , Dyslipidemias/prevention & control , Cardiovascular Diseases/complications , Cholesterol, HDL/adverse effects , Impacts on Health/prevention & control
3.
Int. j. morphol ; 36(1): 273-278, Mar. 2018. tab, graf
Article in English | LILACS (Americas) | ID: biblio-893222

ABSTRACT

SUMMARY: The reduction of ovarian function and a decrease in estrogen levels marked by menopause are related to increased susceptibility to develop dyslipidemia. These alterations in the lipid profile can have consequences in renal tissue and generate injuries that may progress to renal failure. The practice of physical activity is an important factor for the treatment and prevention of dyslipidemia and its consequences. The objective of this study is to observe the effects of physical exercise on the right kidney of ovariectomized female LDL knockout mice. Animals were submitted to moderate physical exercise, sacrificed, and the right kidney was removed for morphometric and stereological analysis. The results showed that dyslipidemia promoted a decrease in the areas of the corpuscle and renal glomerulus, in the volume density of light in both the proximal and distal convoluted tubules, and an increase in capsular space, particularly more marked in the proximal tubules. We also observed that physical exercise decreased the analyzed parameters. Our results suggest the association of physical training and dyslipidemia presents a tendency to reduce the dimensions of morphometric and stereological parameters of the kidney. These changes may be related to metabolic and physiological adaptation of renal tissue during physical exercise.


RESUMEN: La reducción de la función ovárica y una disminución en los niveles de estrógeno, marcados por la menopausia, se relacionan con una mayor susceptibilidad a desarrollar dislipidemia. Estas alteraciones en el perfil lipídico pueden tener consecuencias en el tejido renal y generar lesiones que pueden progresar a insuficiencia renal. La práctica de la actividad física es un factor importante para el tratamiento y la prevención de la dislipidemia y sus consecuencias. El objetivo de este estudio fue observar los efectos del ejercicio físico en el riñón derecho de ratones hembras con LDL ovariectomizados. Los animales fueron sometidos a ejercicio físico moderado, se sacrificaron y se extrajo el riñón derecho para el análisis morfométrico y estereológico. Los resultados mostraron que la dislipidemia promovió una disminución en las áreas del corpúsculo y el glomérulo renal, en la densidad volumétrica de la luz en los túbulos contorneados proximales y distales, y un aumento en el espacio capsular, particularmente más marcado en los túbulos proximales. También observamos que el ejercicio físico disminuyó los parámetros analizados. Nuestros resultados sugieren que la asociación del entrenamiento físico y la dislipidemia presentan una tendencia a reducir las dimensiones de los parámetros morfométricos y estereológicos del riñón. Estos cambios pueden estar relacionados con la adaptación metabólica y fisiológica del tejido renal durante el ejercicio físico.


Subject(s)
Animals , Female , Mice , Dyslipidemias/pathology , Exercise , Kidney/pathology , Ovariectomy , Body Mass Index , Dyslipidemias/prevention & control , Mice, Knockout
4.
Braz. j. med. biol. res ; 51(6): e7253, 2018. tab
Article in English | LILACS (Americas) | ID: biblio-889103

ABSTRACT

The prevalence of cardiovascular and metabolic diseases is increased in postmenopausal women, which contributes to the burden of illnesses in this period of life. Yerba mate (Ilex paraguariensis) is a native bush from Southern South America. Its leaves are rich in phenolic components, which may have antioxidant, vasodilating, hypocholesterolemic, and hypoglycemic proprieties. This post hoc analysis of the case-control study nested in the Obesity and Bone Fracture Cohort evaluated the consumption of yerba mate and the prevalence of hypertension, dyslipidemia, and coronary diseases in postmenopausal women. Ninety-five postmenopausal women were included in this analysis. A questionnaire was applied to evaluate the risk factors and diagnosis of cardiovascular diseases and consumption of yerba mate infusion. Student's t-test and chi-square test were used to assess significant differences between groups. The group that consumed more than 1 L/day of mate infusion had significantly fewer diagnoses of coronary disease, dyslipidemia, and hypertension (P<0.049, P<0.048, and P<0.016, respectively). Furthermore, the serum levels of glucose were lower in the group with a higher consumption of yerba mate infusion (P<0.013). The serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides were similar between the groups. This pragmatic study points out the benefits of yerba mate consumption for the cardiovascular and metabolic systems. The ingestion of more than 1 L/day of mate infusion was associated with fewer self-reported cardiovascular diseases and lower serum levels of glucose. Longitudinal studies are needed to evaluate the association between yerba mate infusion and reduction of cardiovascular diseases in postmenopausal women.


Subject(s)
Humans , Female , Aged , Cardiovascular Diseases/prevention & control , Postmenopause/drug effects , Ilex paraguariensis/chemistry , Plant Preparations/administration & dosage , Diabetes Mellitus/prevention & control , Dyslipidemias/prevention & control , Case-Control Studies
5.
Rev. cuba. med. mil ; 46(1): 64-74, ene.-mar. 2017. tab
Article in Spanish | LILACS (Americas) | ID: biblio-901202

ABSTRACT

Introducción: los pacientes prediabéticos poseen riesgo de desarrollo de diabetes mellitus. Su diagnóstico precoz puede prevenir la aparición de esta condición metabólica. Objetivo: identificar la prevalencia de pacientes con prediabetes durante el chequeo médico y la caracterización de algunos aspectos clínicos y epidemiológicos. Métodos: se realizó un estudio observacional, descriptivo y transversal en el Hospital Militar Docente Dr. Mario Muñoz Monroyde Matanzas. La muestra estuvo constituida por 434 individuos a los que se les diagnosticó prediabetes. Resultados: predominó el sexo masculino (88 por ciento), siendo más frecuente para ambos sexos el grupo de edad de 45 a 54 años. En la categoría de glicemia en ayunas alterada hubo 234 pacientes (54 por ciento), 139 (32 por ciento) con tolerancia a la glucosa alterada y 61 (14 por ciento) portadores de prediabetes doble. El factor de riesgo más frecuente fue la dislipidemia, seguido del índice de masa corporal mayor e igual de 25 y la edad mayor de 45 años. En las enfermedades concomitantes predominó la hipertensión arterial esencial (68 por ciento) y la cardiopatía isquémica (25 por ciento). En el estado nutricional predominaron los sobrepesos y obesos con el 54 y 47 por ciento, respectivamente. Conclusiones: en la atención secundaria de salud fue detectada precozmente una elevada prevalencia de pacientes con riesgo de desarrollo de diabetes mellitus tipo 2 que desconocían su condición(AU)


Introduction: Pre-diabetic patients are at risk of developing diabetes mellitus. Early diagnosis can prevent the onset of this metabolic condition. Objective: To identify the prevalence of patients with prediabetes during the medical check-up, and at the same time to characterize some clinical and epidemiological aspects. Methods: An observational, descriptive and cross-sectional study was conducted at the Military Teaching Hospital Dr. Mario Muñoz Monroy from Matanzas. The sample consisted of 434 individuals who were diagnosed with prediabetes. Results: The male sex predominated (88 percent), being more frequent for both sexes the age group of 45 to 54 years. In the altered fasting glycemia category, there were 234 patients (54 percent), 139 (32 percent) with impaired glucose tolerance and 61 (14 percent) patients with double prediabetes. The most frequent risk factor was dyslipidemia, followed by a greater and equal body mass index of 25 and age over 45 years. In the concomitant diseases, essential hypertension predominated (68 percent) and ischemic heart disease (25 percent). In the nutritional status, overweight and obese were predominant with 54 and 47 percent, respectively. Conclusions: At secondary health care, a high prevalence of patients with risk of developing type 2 diabetes mellitus who did not know their condition was detected early(AU)


Subject(s)
Humans , Male , Middle Aged , Prediabetic State/epidemiology , Secondary Care/statistics & numerical data , Risk Factors , Early Diagnosis , Diabetes Mellitus/epidemiology , Epidemiology, Descriptive , Cross-Sectional Studies , Dyslipidemias/prevention & control , Observational Study
9.
Rev. cuba. pediatr ; 86(4): 433-444, oct.-dic. 2014. tab
Article in Spanish | LILACS (Americas), CUMED | ID: lil-730318

ABSTRACT

INTRODUCCIÓN: actualmente hay consenso en que el proceso aterosclerótico se inicia en la infancia, y la dislipidemia es uno de los principales factores de riesgo aterogénicos que deben ser estudiados, así como la valoración nutricional para una adecuada prevención. OBJETIVO: identificar algunas señales de aterosclerosis tempranas como el sobrepeso y las dislipidemias en adolescentes. MÉTODOS: se realizó un estudio descriptivo transversal de 372 adolescentes de la Secundaria Básica "Protesta de Baraguá". Se hicieron mediciones de peso, talla, índice de masa corporal y circunferencia de la cintura. Se tomó muestra de sangre venosa con ayuno de 12 horas. Se midió el colesterol total, el colesterol unido a lipoproteína baja y alta densidad, y triglicéridos. En el análisis estadístico se realizaron prueba de comprobación de media entre variables de valoración nutricional y lipídicas entre sexos (prueba t), y se trabajó con una probabilidad de error menor de 0,05. RESULTADOS: la media del peso, talla y circunferencia de la cintura fueron mayores en el sexo masculino (p< 0,05). El exceso de peso fue 23,7 %, y a partir del percentil 90-97 hubo un 21,8 % de exceso de grasa abdominal. La media del colesterol total, lipoproteínas de alta y baja densidad y triglicéridos, fue similar en los diferentes sexos, sin relación significativa (p> 0,05). El 18,5 % presentó colesterol total limítrofe alto, el 26,6 % tenía triglicéridos limítrofe alto y 7,5 % alto, con predominio del sexo femenino. CONCLUSIONES: alrededor de la cuarta parte de los adolescentes tenían exceso de peso e incremento de la grasa abdominal, casi la cuarta parte tenía el colesterol total limítrofe y alto, y la alteración lipídica observada con mayor frecuencia fue la hipertrigliceridemia.


INTRODUCTION: there is a current consensus that the atherosclerotic process begins at childhood and that dyslipidemia is one of the atherogenic risk factors to be studied together with the nutritional assessment for the adequate prevention of atherosclerosis. OBJECTIVE: to identify some early signs of atherosclerosis such as overweight and dyslipidemias in teenagers. METHODS: a cross-sectional descriptive study of 372 teenagers from "Protesta de Baragua" junior high school. Weight, height, body mass index and waist circumference were measured. Blood samples were taken after 12 hour fasting. Total cholesterol, low and high density lipoprotein cholesterol and triglyceride were all measured. The statistical analysis included the t test among nutritional assessment and lipid variables between sexes and the error probability was lower than 0.05. RESULTS: weight, height and waist circumference means were higher in males (p< 0.05). Overweight was 23.7 % and from the 90-97th percentile, the excessive abdominal fat was 21.8 %. The mean of total cholesterol, high and low density lipoproteins and triglycerides was similar in both sexes, with no significant relation (p> 0.05). In this group, 18.5 % of adolescents presented with borderline high total cholesterol, 26.6 % showed borderline high triglyceride rate and 7.5 % had high cholesterol, being females predominant. CONCLUSIONS: one fourth of adolescents approximately exhibited overweight and increased abdominal fat; almost 25 % had reached borderline and high total cholesterol whereas the most observed lipid disorder was hypertrigliceridemia.


Subject(s)
Humans , Adolescent , Hypertriglyceridemia/diagnosis , Hypertriglyceridemia/prevention & control , Weight Gain/physiology , Abdominal Fat/growth & development , Atherosclerosis/prevention & control , Dyslipidemias/prevention & control , Epidemiology, Descriptive , Cross-Sectional Studies
10.
Rev. chil. pediatr ; 85(3): 367-377, jun. 2014. ilus, tab
Article in Spanish | LILACS (Americas) | ID: lil-719145

ABSTRACT

La prevalencia de dislipidemias ha aumentado en niños y adolescentes, muchas de ellas asociadas al incremento de la obesidad. Puesto que constituyen un factor de riesgo cardiovascular futuro, deben conocerse las bases de su tratamiento. En la gran mayoría de los pacientes, éste consiste en cambios de estilo de vida, con dieta específica y aumento de la actividad física, presentando habitualmente una respuesta favorable. Solo una minoría requiere tratamiento medicamentoso, el que debe ser realizado por especialista en el contexto de una evaluación completa del perfil de riesgo cardiovascular, con la inclusión del paciente y su familia. Sin embargo, la prevención de los factores de riesgo cardiovascular debe ser realizada por todos los miembros del equipo de salud. Este artículo presenta las recomendaciones de la Rama de Nutrición de la Sociedad Chilena de Pediatría para el diagnóstico, tamizaje y tratamiento de las dislipidemias en la niñez.


The prevalence of dyslipidemia has dramatically increased in children and adolescents, and many of these cases are associated with increased obesity. As this condition represents cardiovascular risk in the future, the bases of its treatment should be widely known. In the vast majority of patients, there will be lifestyle changes, specific diet and increased physical activity, usually all of these resulting in a favorable response. Only a minority will require drug treatment, which must be prescribed by a specialist in the context of a comprehensive cardiovascular risk assessment, including the patient and his family. The prevention of cardiovascular risk factors should be performed by all members of the health team. This article presents the recommendations of the Nutrition specialists of the Chilean Society of Pediatrics for screening, diagnosis and treatment of dyslipidemia in childhood.


Subject(s)
Humans , Adolescent , Child , Adolescent Nutrition , Child Nutrition , Dyslipidemias/diagnosis , Dyslipidemias/prevention & control , Algorithms , Dyslipidemias/therapy , Cardiovascular Diseases/prevention & control , Hypercholesterolemia , Hypertriglyceridemia , Mass Screening
11.
Rev. cuba. endocrinol ; 24(3): 229-241, sep.-dic. 2013.
Article in Spanish | LILACS (Americas) | ID: lil-705640

ABSTRACT

Antecedentes: la adherencia terapéutica en las dislipoproteinemias es un elemento esencial en la prevención de las complicaciones de la aterosclerosis. Objetivos: determinar el nivel de adherencia en pacientes con dislipoproteinemias, e identificar los factores relacionados con esta. Métodos: estudio descriptivo, de corte transversal. Incluyó 91 sujetos que acudieron a la consulta de dislipoproteinemias en el Centro de Atención al Diabético del Instituto Nacional de Endocrinología, en La Habana, Cuba, en el periodo de enero a junio de 2011, con ³ 20 años de edad y al menos 12 semanas de asistir a la consulta. Fue aplicado un cuestionario anónimo y auto administrado, dividido en 3 secciones, que incluyeron variables relacionadas con la caracterización del grupo, como: sexo, grupo de edad, escolaridad, ocupación; categorías que describen la adherencia; y factores relacionados con esta. Se calcularon estadísticas descriptivas y se utilizó la prueba chi². Resultados: el rango de edad predominante fue de 40 a 59 años (94,9 por ciento). El 85,8 por ciento eran preuniversitarios, y el 40,7 por ciento de la muestra presentó adherencia terapéutica. El cumplimiento de la dieta, del horario y de las dosis de los fármacos se asoció significativamente con la adherencia terapéutica (p< 0,05). Conclusiones: la mayoría de los pacientes no presentaron adherencia terapéutica, en relación con el incumplimiento de la dieta y de la práctica de ejercicios. En un grupo menor de pacientes el cumplimiento del horario y la dosis del medicamento correspondieron con la mejor adhesión. Los factores que obstaculizan la adherencia terapéutica resultaron ser la carencia de frutas y vegetales en el mercado, así como también el abandono de la dieta. Los factores favorecedores fueron el adecuado apoyo familiar y la correcta información brindada por el médico de asistencia(AU)


Background: adherence to treatment in dyslipoproteinemias is an essential element for the prevention of atherosclerosis complications. Objectives: to determine the extent of adherence to treatment in patients with dyslipoproteinemias and to identify the factors related to it. Methods: a cross-sectional and descriptive study of 91 individuals who went to the dyslipoproteinemias service of the Center of Care for Diabetic Patients in the National Institute of Endocrinology in Havana, Cuba from January to June 2011. They were aged ³ 20 years and attended this service for at least 12 weeks. A self-administered anonymous questionnaire divided into 3 sections was applied; it included variables about the group characterization such as sex, age group, schooling, occupation, categories describing adherence to treatment and factors related to it. Summary statistics were estimated and chi-square test was used. Results: the predominant age group was 40 to 59 years (94.9 percent). In this sample, 85.8 percent had finished high school and 40.7 percent showed adherence to treatment. Compliance with diet, meal times and drug doses was significantly associated to adherence to treatment (p< 0.05). Conclusions: most of patients did not comply with treatment in terms of diet and exercising. In a lower number of patients, compliance with meal times and drug doses were related to better adherence to treatment. The factors hindering the adherence proved to be lack of fruits and vegetables at the marketplace as well as ignoring diet. The favoring factors were adequate family support and correct information provided by the attending physician(AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Atherosclerosis/complications , Dyslipidemias/prevention & control , Treatment Adherence and Compliance/statistics & numerical data , Exercise , Epidemiology, Descriptive , Cross-Sectional Studies
13.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 22(2): 18-23, abr.-jun. 2012.
Article in Portuguese | LILACS (Americas) | ID: lil-681080

ABSTRACT

O controle de fatores de risco foi uma das estratégias que se acompanhou de redução na taxa de eventos cardiovasculares em 50% nos Estados Unidos da América. Meta-análise de estudos com estatinas mostrou redução de 20% de desfechos em prevenção primária e secundária de doenças cardiovasculares para diminuição de 39 mg/dL do LDL-c. Já para reduções de LDL-c de 80 a 120 mg/dL, as diminuições das taxas de desfechos são da ordem de 40%-50%. O tratamento hipolipemiante deve ser feito de maneira contínua, é seguro , podendo ocorrer eventos diversos, de modo geral reversíveis e de ocorrência infrequente. O conhecimento das interações farmacocinéticas, do perfil de segurança dos farmácos e de fatores de risco para eventos adversos permite um correto manuseio do tratamento hipiolipemiante e minimiza potenciais riscos.


Risk factors control is one of the most important strategies in the United States of America. Meta-analyses of studies in primary and secondary prevention with statins have shown that a 20% reduction in outcomes was observed for a 1 mmol/L reduction in LDL-c (of 2-3 mmol/L) a 40%-50% decrease in cardiovascular event was observed. Lipid-lowering therapy has to be given continuosly, it is safe, with infrequent and reversible adverse events that can be prevented by appropiate information on pharmacokinetic interactions, risk for drug profile and risk factors for adverse events to promote a correct management of lipid-lowering therapy and minimize potential risks.


Subject(s)
Humans , Dyslipidemias/complications , Dyslipidemias/prevention & control , Cardiovascular Diseases/complications , Cardiovascular Diseases/prevention & control , Hypolipidemic Agents/administration & dosage , Health Promotion/methods , Health Promotion/trends , Risk Factors
14.
Iranian Journal of Nutrition Sciences and Food Technology. 2012; 6 (4): 1-12
in Fa | IMEMR (Eastern Mediterranean) | ID: emr-117564

ABSTRACT

Considering the high prevalence of hypertension and dyslipidemia in type 2 diabetic patients, the aim of the present study was to investigate the effects of probiotic yoghurt on blood pressure and serum lipid concentrations in these patients. In this controlled, double-blind, randomized clinical trial, 60 patients [23 males and 37 females] with type 2 diabetes and an LDL-cholesterol level higher than 100 mg/dL were assigned to one of two groups. Subjects in the intervention group consumed daily 300 gr of probiotic yoghurt containing Lactobacillus acidophilus and Bifidobacterium lactis, and those in the control group consumed daily 300 gr of conventional yoghurt, for 6 weeks. Dietary intakes, anthropometric measurements, blood pressure and serum lipids concentrations were measured at the baseline and at the end of the study. Statistical analyses were performed using the SPSS software, the statistical tests being analysis of covariance and paired-samples t-test. Systolic and diastolic blood pressure remained unchanged in both groups, while the total cholesterol and LDL-cholesterol concentrations decreased by 4.54% and 7.45% in the intervention group, respectively, as compared with the control values [P = 0.008 andP = 0.004, respectively]. However, no significant differences were observed between the initial and final triglyceride and HDL-cholesterol concentrations in the intervention group. Consumption of probiotic yoghurt can decrease the total cholesterol and LDL-cholesterol in type 2 diabetic patients; however, it has no effect on blood pressure. This study shows that probiotic yoghurt may help reduce cardiovascular disease risk factors in type 2 diabetes


Subject(s)
Humans , Male , Female , Hypertension/prevention & control , Dyslipidemias/prevention & control , Diabetes Mellitus, Type 2/complications , Double-Blind Method , Lipids/blood
15.
Salud(i)ciencia (Impresa) ; 18(7): 631-634, nov. 2011. tab
Article in Spanish | LILACS (Americas) | ID: lil-654083

ABSTRACT

Los valores elevados de glucosa y de colesterol asociado a lipoproteínas de baja densidad (LDLc) y la baja concentración de colesterol asociado a lipoproteínas de alta densidad (HDLc) en los niños se vinculan con un alto riesgo de enfermedad cardiovascular en la vida adulta. El objetivo de este estudio fue realizar una revisión de la dislipidemia en niños de países tanto desarrollados como en vías de desarrollo durante el siglo XXI. Se llevó a cabo una búsqueda bibliográfica por computadora y se instó a algunos especialistas en el tema a que enviasen sus trabajos publicados y los aún no publicados. Dado que los factores ambientales y genéticos juegan un papel importante en el proceso de la dislipidemia aterogénica, se sostiene que los cambios del estilo de vida desde edades tempranas constituyen soluciones sustentables para alcanzar una población saludable. En este aspecto, las responsabilidades personales y familiares resultan cruciales; es necesario destacar las fallas del gobierno en ayudar y controlar los importantes factores ambientales que están llevando a nuestros niños a padecer enfermedades prematuras y una mayor mortalidad. Es necesario realizar estudios más amplios en cuanto a los criterios diagnósticos y los tratamientos de la dislipidemia en niños y adolescentes si se desea revertir el futuro de su salud cardiovascular y otras complicaciones asociadas con la dislipidemia


Subject(s)
Dyslipidemias/diagnosis , Dyslipidemias/epidemiology , Dyslipidemias/prevention & control , Dyslipidemias/therapy , Cardiovascular Diseases/diagnosis , Cardiovascular Diseases/prevention & control , Pediatrics/instrumentation
17.
Physis (Rio J.) ; 21(2): 417-436, 2011.
Article in Portuguese | LILACS (Americas) | ID: lil-596060

ABSTRACT

O presente artigo aborda os aspectos clínicos e socioeconômicos decorrentes da presença de dislipidemias em portadores de doenças cardiovasculares (DCV). Existem inúmeros estudos relacionados às DCV, uso de hipolipemiantes orais como as estatinas, e os aspectos econômicos envolvidos com impacto na área da saúde. Além de evidenciar a importância do tratamento das dislipidemias, o artigo busca demonstrar o ponto de vista farmacoeconômico, ou seja, dos custos gerados com o tratamento farmacológico desta patologia versus os custos decorrentes dos eventos cardiovasculares acometidos e suas consequências. Existe, portanto, relevante relação entre os impactos sociais decorrentes de incapacidade física e laborativa, aposentadorias precoces, entre outros custos importantes que poderiam ser evitados com uma análise econômica abrangente e eficiente realizada nos serviços de saúde do Brasil. Neste contexto, é enfatizada a importância da análise conjunta dos aspectos clínicos e socioeconômicos das dislipidemias que poderiam influenciar nas decisões das autoridades de saúde no momento da elaboração de protocolos clínicos de tratamentos farmacológicos a serem implementados no SUS.


This paper discusses the clinical and socioeconomic factors arising from the presence of dyslipidemia in patients with cardiovascular disease (CVD). There are numerous studies related to CVD, oral use of statins as statins, and the economics aspects involved with an impact on health. In addition to demonstrating the importance of the treatment of dyslipidemia, the paper shows the pharmacoeconomic viewpoint, i.e. costs generated by the pharmacological treatment of this disease versus the costs of cardiovascular events and their consequences. There is therefore relevant relationship between the social impacts arising from physical disability and work, early retirements, among other important costs that could be avoided with a comprehensive economic analysis and efficient health services in Brazil. In this context, we emphasize the importance of joint analysis of the clinical and socioeconomic aspects of dyslipidemia that could influence the decisions of health authorities at the time of preparation of clinical protocols of pharmacological treatments to be implemented within the SUS.


Subject(s)
Humans , Male , Female , Diagnosis , Dyslipidemias/diet therapy , Dyslipidemias/prevention & control , Cardiovascular Diseases/diagnosis , Cardiovascular Diseases/pathology , Critical Pathways/economics , Socioeconomic Factors , Unified Health System/economics , Brazil/epidemiology , Brazil/ethnology , Economics, Pharmaceutical , Hyperlipidemias/complications , Hyperlipidemias/diet therapy , Hyperlipidemias/prevention & control , Hypertriglyceridemia/prevention & control , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Primary Prevention/economics , Secondary Prevention
18.
In. Spina, Guilherme S. TEC: título de especialista em cardiologia: guia de estudo. São Paulo, nVersos, 2011. p.149-187.
Monography in Portuguese | LILACS (Americas) | ID: lil-594755
19.
Bahrain Medical Bulletin. 2011; 33 (4): 179-184
in English | IMEMR (Eastern Mediterranean) | ID: emr-143996

ABSTRACT

To evaluate lipid control and drugs used in the management of diabetic people with dyslipidemia. A retrospective clinical study. NBB Dair Health Center. Copies of prescriptions for people with diabetes from 2 January 2011 to 30 April 2011 were retrieved. Prescriptions containing anti-lipid medications were screened. The charts of these patients were reviewed. Data collected include age, sex, lipid profile, drug used and its dose, compliance with liver enzymes monitoring and their levels and the use of combination drugs. In addition, the total number of visits made by the patients during 2010 was documented. Four hundred twenty-six patients were included in the study. Two hundred sixty [61%] were females. Two hundred fifty-five patients [59.8%] achieved LDL <2.6 [<100 mg/dL]. Triglycerides target [<1.7; <150 mg/dL] was achieved in 247 [58%] patients. HDL target [>1; >40] was achieved in 297 [69.7%] patients; one hundred thirty-three patients [31.2%] achieved these three targets. Two hundred thirty-three patients [55%] were using either Pravastatin 20 mg or Simvastatin 20 mg. Four patients [0.94%] were on combination of a statin and Bezafibrate. No significant gender difference in the level of control and statins doses was found. The study revealed that the management of dyslipidemia among people with diabetes is suboptimal. Using moderate to high potency statins and/or combination is needed to increase the number of patients who meet guidelines recommendations


Subject(s)
Humans , Male , Female , Dyslipidemias/prevention & control , Diabetes Mellitus/epidemiology , Hydroxymethylglutaryl-CoA Reductase Inhibitors
20.
Rev. paul. pediatr ; 28(4): 373-380, out.-dez. 2010. tab
Article in Portuguese | LILACS (Americas) | ID: lil-571761

ABSTRACT

OBJETIVO: Revisar os potenciais efeitos antioxidantes das vitaminas A, C e E na prevenção do desenvolvimento da arteriosclerose na infância, com ênfase na prevenção da dislipidemia. FONTES DE DADOS: Pesquisa bibliográfica em revistas científicas, livros técnicos e publicações de órgãos oficiais dos últimos 20 anos. Utilizaram-se as bases de dados Lilacs, SciELo e Medline em português, inglês e espanhol, com as palavras-chave: "antioxidantes", "arteriosclerose", "dislipidemias", "peroxidação de lipídeos", "infância", "vitamina A", "vitamina C" e "vitamina E". SÍNTESE DE DADOS: A prevalência de dislipidemia na infância e na adolescência mostra frequência crescente, provavelmente relacionada às mudanças dos hábitos alimentares e à redução na prática de atividades físicas. O elevado nível plasmático da lipoproteína de baixa densidade (LDL-c) é fator de risco para o desenvolvimento da arteriosclerose. O consumo de frutas, verduras e legumes, ricos em antioxidantes, é um dos fatores de maior importância na prevenção da peroxidação lipídica. A baixa ingestão dessas fontes naturais de antioxidantes sugere a necessidade de intervenção nutricional para atingir as metas diárias de consumo de vitaminas A, C e E, não sendo preconizada a sua suplementação medicamentosa. CONCLUSÕES: O pediatra e o nutricionista devem orientar as famílias sobre o consumo de alimentos saudáveis, principalmente frutas, verduras e legumes, por seu potencial efeito antioxidante, especialmente nos primeiros anos de vida.


OBJECTIVE: To review the potential antioxidant effects of vitamins A, C and E in the prevention of atherosclerosis development during childhood, emphasizing the prevention of dyslipidemia. DATA SOURCES: Bibliographic search in scientific journals, technical books and official publications of the last 20 years. Lilacs, SciElo and Medline databases were searched for articles in Portuguese, Spanish and English using a combination of the following terms: "antioxidants", "atherosclerosis", "dyslipidemia", "lipid peroxidation", "childhood", "vitamin A", "vitamin C" and "vitamin E". DATA SYNTHESIS: There is an increasing prevalence of dyslipidemia in children and adolescents, probably related to changes in dietary habits and to the reduced practice of physical activities. The high plasma concentration of low-density lipoprotein (LDL-c) is a risk factor for atherosclerosis development. The consumption of nutrients rich in antioxidants, such as fruits and vegetables, is very important to prevent lipid peroxidation. The low intake of these natural antioxidants sources suggests the need for nutritional intervention to achieve the daily ingestion targets of vitamins A, C and E. Vitamin supplementation is not recommended. CONCLUSIONS: Children should be encouraged to increase ingestion of fruits and vegetables due to their potential antioxidant effect, especially in the first years of life.


Subject(s)
Humans , Male , Female , Child , Adolescent , Antioxidants , Arteriolosclerosis/prevention & control , Dyslipidemias/prevention & control , Lipid Peroxidation
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