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2.
Evid. actual. práct. ambul ; 23(3): e002070, 2020.
Article in Spanish | LILACS | ID: biblio-1120506

ABSTRACT

La dispepsia constituye un motivo de consulta frecuente en atención primaria. A propósito de un paciente con diagnóstico de dispepsia funcional, la autora se plantea si el tratamiento de erradicación del Helicobacter pylori podría mejorar los síntomas. Luego de una búsqueda rápida se encontró evidencia que señala que el tratamiento de la infección por este germen podría ser beneficiosa para aliviar los síntomas de la dispepsia funcional a largo plazo, aunque con mayor riesgo de efectos adversos, por lo que otros tratamientos alternativos continúan siendo ser una opción válida en el manejo de los pacientes con este problema de salud. (AU)


Subject(s)
Humans , Male , Middle Aged , Helicobacter Infections/drug therapy , Dyspepsia/drug therapy , Primary Health Care , Abdominal Pain/etiology , Helicobacter pylori , Helicobacter Infections/diagnosis , Helicobacter Infections/etiology , Helicobacter Infections/therapy , Dyspepsia/diagnosis , Dyspepsia/etiology , Dyspepsia/therapy , Heartburn/etiology , Anti-Bacterial Agents/therapeutic use
4.
Rev. méd. Chile ; 147(11): 1382-1389, nov. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1094167

ABSTRACT

Background Chile has one of the highest mortality rates by gastric cancer (GC) worldwide. Primary prevention of GC and detection of pre-neoplastic and early neoplastic lesions should be a national priority. Aim To assess the impact of the protocolization of endoscopy referral and the use of H. pylori stool antigen test (HPSA) in the management of dyspepsia to decrease the waiting list for endoscopy and increase the detection of gastric pre-neoplastic and early neoplastic lesions. Material and Methods We included all patients referred to the Endoscopy Unit of a regional hospital, from January 2015 to December 2017. We also included patients with known pre-neoplastic lesions and all those with first degree relatives with GC. We implemented protocols for referral of patients with dyspepsia considering the use of HPSA test, prioritizing to endoscopy those with a higher risk of GC. Results A total of 4,641 endoscopies and 2,631 HPSA tests were carried out. After the adoption of these protocols, we observed a 52% decrease in the waiting time for endoscopy. The GC detection rate in this period was 1.8 to 3.1 cases per 100 endoscopies. After the adoption of the protocols, we observed a significant increase in early GC detection rate (from none in 2015 to 13% in 2017, p = 0.03). Conclusions The protocolization of the referral for endoscopy associated with widespread use of HPSA test in the management of patients with dyspepsia, are successful strategies to decrease waiting lists for endoscopy and optimize the detection rate of pre-neoplastic lesions and early GC.


Subject(s)
Humans , Precancerous Conditions/diagnosis , Waiting Lists , Helicobacter pylori/isolation & purification , Helicobacter Infections/diagnosis , Dyspepsia/diagnosis , Feces/microbiology , Antigens, Bacterial/analysis , Precancerous Conditions/microbiology , Primary Health Care , Referral and Consultation , Helicobacter Infections/complications , Helicobacter Infections/microbiology , Sensitivity and Specificity , Early Diagnosis , Dyspepsia/microbiology , Endoscopy/statistics & numerical data
5.
Braz. j. infect. dis ; 22(4): 311-316, July-Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-974231

ABSTRACT

ABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows: CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Polymorphism, Genetic , Helicobacter pylori/drug effects , Helicobacter Infections/drug therapy , Dyspepsia/drug therapy , Interleukin-1beta/genetics , Anti-Bacterial Agents/therapeutic use , Omeprazole/therapeutic use , Double-Blind Method , Follow-Up Studies , Helicobacter pylori/genetics , Treatment Outcome , Clarithromycin/therapeutic use , Dyspepsia/diagnosis , Genotype , Amoxicillin/therapeutic use , Anti-Ulcer Agents/therapeutic use
6.
Rev. Soc. Bras. Med. Trop ; 51(2): 183-189, Mar.-Apr. 2018. tab
Article in English | LILACS | ID: biblio-897069

ABSTRACT

Abstract INTRODUCTION: Helicobacter pylori, a water contaminant, is the primary pathogenic agent associated with gastric diseases in humans. Exposure to H. pylori is more likely higher in developing countries. This study aimed to evaluate the risk factors associated with H. pylori infection in patients undergoing endoscopy to validate the cause of dyspeptic symptoms in an urban population in northeast Brazil and to compare the urease test and polymerase chain reaction assay results with the histopathological findings. METHODS: We evaluated 200 of 759 individuals with dyspeptic complaints from Campina Grande, State of Paraiba, northeast Brazil. Patients underwent endoscopy, followed by gastric biopsies. Logistic regression analysis was performed to adjust for confounders and to determine significant risk factors of dyspeptic disorders. RESULTS: Women accounted for 72.5% (145/200) of the participants. Approximately 59.8% (120/200) of the samples tested positive for H. pylori based on histological examinations. The specificity of polymerase chain reaction assay was higher than that of the urease test (77% vs. 64%, p=0.034). City drinking water [odds ratio (OR): 2.6; 95% confidence interval (CI): 1.3-5.21; p=0.004] and smoking (OR: 4.0; 95% CI: 1.13-14.5; p=0.031) were the risk factors of H. pylori infection. Belching was the most common symptom associated with H. pylori infection (p=0.05). CONCLUSIONS: The increased risk of H. pylori infection associated with non-treated water consumption indicates the need for improvements in public water treatment and better sanitary conditions because these can be a source of not only H. pylori infections but also other water-borne pathogen infections.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Helicobacter pylori/isolation & purification , Helicobacter Infections/diagnosis , Duodenal Ulcer/microbiology , Dyspepsia/microbiology , Gastritis/microbiology , Socioeconomic Factors , Urban Population , Polymerase Chain Reaction , Risk Factors , Endoscopy, Gastrointestinal , Helicobacter pylori/genetics , Sensitivity and Specificity , Duodenal Ulcer/diagnosis , Dyspepsia/diagnosis , Gastritis/diagnosis , Middle Aged
7.
Rev. gastroenterol. Mex ; 82(4): 309-327, oct.-dec. 2017.
Article in Spanish | LILACS, BIGG | ID: biblio-966188

ABSTRACT

Desde la publicación de las guías de dispepsia 2007 de la Asociación Mexicana de Gastroenterología ha habido avances significativos en el conocimiento de esta enfermedad. Se realizó una revisión sistemática de la literatura en PubMed (01/2007 a 06/2016) con el fin de revisar y actualizar las guías 2007 y proporcionar nuevas recomendaciones basadas en evidencia. Se incluyeron todas las publicaciones en español e inglés, de alta calidad. Se redactaron enunciados que fueron votados utilizando el método Delphi. Se estableció la calidad de la evidencia y la fuerza de las recomendaciones según el sistema GRADE para cada enunciado. Treinta y un enunciados fueron redactados, votados y calificados. Se informan nuevos datos sobre definición, clasificación, epidemiología y fisiopatología. La endoscopia debe realizarse en dispepsia no investigada cuando hay datos de alarma o falla al tratamiento. Las biopsias gástricas y duodenales permiten confirmar infección por Helicobacter pylori y excluir enfermedad celiaca, respectivamente. Establecer una fuerte relación médico-paciente, cambios en la dieta y en el estilo de vida son útiles como medidas iniciales. Los bloqueadores H2, inhibidores de la bomba de protones, procinéticos y fármacos antidepresivos son efectivos. La erradicación de H. pylori puede ser eficaz en algunos pacientes. Con excepción de Iberogast y rikkunshito, las terapias complementarias y alternativas carecen de beneficio. No existe evidencia con respecto a la utilidad de prebióticos, probióticos o terapias psicológicas. Los nuevos enunciados proporcionan directrices basadas en la evidencia actualizada. Se presenta la discusión, el grado y la fuerza de la recomendación de cada uno de ellos.


Abstract Since the publication of the 2007 dyspepsia guidelines of the Asociación Mexicana de Gastroenterología, there have been significant advances in the knowledge of this disease. A systematic search of the literature in PubMed (01/2007 to 06/2016) was carried out to review and update the 2007 guidelines and to provide new evidence-based recommendations. All high-quality articles in Spanish and English were included. Statements were formulated and voted upon using the Delphi method. The level of evidence and strength of recommendation of each statement were established according to the GRADE system. Thirty-one statements were formulated, voted upon, and graded. New definition, classification, epidemiology, and pathophysiology data were provided and include the following information: Endoscopy should be carried out in cases of uninvestigated dyspepsia when there are alarm symptoms or no response to treatment. Gastric and duodenal biopsies can confirm Helicobacter pylori infection and rule out celiac disease, respectively. Establishing a strong doctor-patient relationship, as well as dietary and lifestyle changes, are useful initial measures. H2-blockers, proton-pump inhibitors, prokinetics, and antidepressants are effective pharmacologic therapies. H. pylori eradication may be effective in a subgroup of patients. There is no evidence that complementary and alternative therapies are beneficial, with the exception of Iberogast and rikkunshito, nor is there evidence on the usefulness of prebiotics, probiotics, or psychologic therapies. The new consensus statements on dyspepsia provide guidelines based on up-to-date evidence. A discussion, level of evidence, and strength of recommendation are presented for each statement. © 2017 Asociacion Mexicana de Gastroenterologiia.


Subject(s)
Humans , Adult , Dyspepsia/diagnosis , Dyspepsia/therapy , Endoscopy, Gastrointestinal , Helicobacter pylori/drug effects , Helicobacter Infections , Helicobacter Infections/diagnosis , Helicobacter Infections/therapy , Dyspepsia , Dyspepsia/drug therapy , Dyspepsia/epidemiology
8.
Arq. gastroenterol ; 53(2): 108-112, April.-June 2016. tab, graf
Article in English | LILACS | ID: lil-783806

ABSTRACT

ABSTRACT Background - Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective - In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods - This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results - The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion - Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended.


RESUMO Contexto - A infecção por Helicobacter pylori, bacilo gram negativo, tem estreita associação com gastrite antral crônica. Objetivo - Neste estudo, avaliou-se a precisão do teste respiratório da urease (UBT) com isótopos de carbono 13 em comparação com a histopatologia do antro gástrico para detecção da infecção por H. pylori em crianças com dispepsia. Métodos - Estudo transversal realizado no laboratório especializado no Centro de Pesquisa Gastroenterológica de Shiraz e do Hospital de Nemazee, Iran, durante um período de 12 meses. Este estudo investigou a sensibilidade, a especificidade e valores preditivos positivos e negativos da UBT em comparação com testes baseados em biópsia. Incluímos uma seleção consecutiva de 60 crianças que preencheram os critérios de Roma III para dispepsia. Todas as crianças foram encaminhadas para a realização de UBT com isótopos de carbono 13 (C13) assim como endoscopia. Biópsias foram tiradas do antro do estômago e duodeno. O diagnóstico patológico era considerado o teste padrão. Resultados - A idade média dos participantes foi 10.1±2.6 (intervalo de 7 a 17 anos). Do nosso total de 60 pacientes, 28 (46,7%) tiveram resultados positivos UBT e 32 (53,3%) tiveram resultados negativos de UBT. Dezesseis (57,1%) de 28 pacientes que tiveram UBT positiva foram H. pylori positivo e 12 (42,9%) foram negativos. A sensibilidade e especificidade do C13-UBT para detecção da infecção por H. pylori foi de 76,2% e 69,2%, respectivamente. Conclusão - A sensibilidade e especificidade do C13-UBT para detecção da infecção por H. pylori foi de 76,2% e 69,2%, respectivamente. Recomenda-se outro estudo multicêntrico de nosso país.


Subject(s)
Humans , Male , Female , Child , Adolescent , Urea/analysis , Helicobacter pylori , Helicobacter Infections/diagnosis , Dyspepsia/diagnosis , Biopsy , Breath Tests , Cross-Sectional Studies , Predictive Value of Tests , Helicobacter Infections/pathology , Sensitivity and Specificity , Dyspepsia/microbiology , Dyspepsia/pathology , Endoscopy
9.
Rev. colomb. gastroenterol ; 30(supl.1): 9-16, oct.-dic. 2015. ilus
Article in Spanish | LILACS, BIGG | ID: lil-776323

ABSTRACT

Objetivo: con la evidencia más reciente, desarrollar una guía de práctica clínica para el manejo de dispepsia dirigida a pacientes, personal asistencial, administrativo y entes gubernamentales de cualquier servicio de atención en Colombia. Materiales y métodos: esta guía fue desarrollada por un equipo multidisciplinario con el apoyo de la Asociación Colombiana de Gastroenterología, el Grupo Cochrane ITS y el Instituto de Investigaciones Clínicas de la Universidad Nacional de Colombia. Se desarrollaron preguntas clínicas relevantes y se realizó la búsqueda de guías nacionales e internacionales en bases de datos especializadas. Las guías existentes fueron evaluadas en términos de calidad y aplicabilidad; una guía cumplió con el criterio de adaptación, por lo que se adaptaron 2 de sus preguntas. El Grupo Cochrane realizó la búsqueda sistemática de la literatura. Las tablas de evidencia y recomendaciones fueron realizadas con base en la metodología GRADE. Las recomendaciones de la guía fueron socializadas en una reunión de expertos con entes gubernamentales y pacientes. Resultados: se desarrolló una guía de práctica clínica basada en la evidencia para el manejo de pacientes con dispepsia en Colombia. Conclusiones: el tamizaje de pacientes asintomáticos en Colombia, de forma adecuada y con estándares de calidad, tiene el potencial de impactar la carga de cáncer de colon en el país.


Objective: To provide an evidence-based clinical practice guideline for the management of dyspepsia for patients, caregivers, administrative and government bodies at all levels of care in Colombia. Materials and Methods: This guide was developed by a multidisciplinary team with the support of the Colombian Association of Gastroenterology, Cochrane STI Group and Clinical Research Institute of the Universidad Nacional de Colombia. Relevant clinical questions were developed and the search for national and international guidelines in databases was performed. Existing guidelines were evaluated for quality and applicability. One guideline met the criteria for adaptation of two of its clinical questions. Systematic literature searches were conducted by the Cochrane STI Group. The tables of evidence and recommendations were made based on the GRADE methodology. The recommendations of the guide were socialized in a meeting of experts with government agencies and patients. Results: An evidence-based Clinical Practice Guidelines for the management of dyspepsia was developed for the Colombian context. Conclusions: The opportune management of dyspepsia would have an impact of the disease in Colombia.


Subject(s)
Humans , Adult , Dyspepsia/diagnosis , Dyspepsia/drug therapy , Gastroscopy , GRADE Approach
10.
Rwanda med. j. (Online) ; 72(3): 5-7, 2015.
Article in English | AIM | ID: biblio-1269627

ABSTRACT

Functional dyspepsia (FD) refers to upper abdominal symptoms like upper abdominal or retrosternal pain or discomfort; heart burn; nausea; etc. The symptoms are common; but often poorly understood and mistaken for conditions like chronic gastritis and peptic ulcer disease. Worldwide; the prevalence of dyspepsia is about 20-30 [1]. In the department of internal medicine at the Ruhengeri hospital; there have been 16.4 outpatient cases and 16.1 cases of admissions (Jan-June-2014). A high number of cases would be in other hospitals as well. The causes postulated are the increased production of acid; visceral hypersensitivity; H. pylori infection; emotional stress; reduced immunity; etc. The diagnosis is based on exclusion of organic causes for similar symptoms. The treatment is mainly with lifestyle modifications; and the pharmacological therapy consists of antacids; antiflatulents; prokinetic drugs; cytoprotective drugs; and proton pump inhibitors. It can be recommended that greater awareness needs to be generated among physicians regarding FD. They in turn can counsel patients and lay stress on lifestyle and preventive factors to improve this described condition


Subject(s)
Dyspepsia/diagnosis , Gastritis , Review , Upper Gastrointestinal Tract
11.
J. bras. med ; 102(4)julho - agosto 2014. tab
Article in Portuguese | LILACS | ID: lil-725927

ABSTRACT

Etmologicamente, a palavra dispepsia (do grego dis = difícil e pepse = digestão) significa digestão difícil. Sob o ponto de vista clínico, corresponde a uma série de sintomas de origem gastroduodenal, como dor, queimação ou desconforto epigástrico, plenitude pós-prandial ou saciedade precoce associadas ou não a náusea, vômitos e distensão em andar superior do abdome. Traduz, pois, um distúrbio funcional ou orgânico, de localização epigástrica e origem gastroduodenal...


Etymologically, the greek word dis means hard and pepse means digestion. Therefore, dyspepsia is a poor digestion. From the clinical point of view, dyspepsia corresponds to a range of symptoms originated from gastroduodenal, like pain, heartburn or epigastric discomfort, postprandial fullness or early fullness related or not to nausea, vomiting, upper abdominal distension. So, this explain that a functional or organic decline situated at the epigastric area and it is originated from gastroduodenal...


Subject(s)
Humans , Male , Female , Dyspepsia/diagnosis , Dyspepsia/therapy , Gastrointestinal Tract/physiopathology , Antidepressive Agents/administration & dosage , Caffeine/adverse effects , Stress, Psychological/complications , Gastric Emptying/physiology , Food and Nutrition Education , Gastrointestinal Agents/therapeutic use , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/physiopathology , Esophageal Motility Disorders/drug therapy , Tobacco Use/adverse effects
12.
Article in English | WPRIM | ID: wpr-105999

ABSTRACT

Dyspepsia refers to group of commonly occurring upper gastrointestinal symptoms. The majority of patients with dyspepsia suffer from functional (nonulcer) dyspepsia. Although there is a lack of epidemiological data from population-based or patient cohort studies in Korea, the current understanding of this condition has been updated using data from various recent research studies, which have facilitated the development of clinical guidelines for functional dyspepsia. According to a survey using the Rome III criteria, more than 40% of respondents who visited primary clinics and tertiary hospitals were defined as having functional dyspepsia, most of who were within a subgroup of patients with postprandial distress syndrome. In addition, a population-based cross-sectional survey revealed considerable overlap between functional dyspepsia and other functional gastrointestinal disorders, including gastroesophageal reflux disease (especially nonerosive reflux disease) and irritable bowel syndrome. In contrast to the results of Western trials, there is insufficient evidence to recommend a Helicobacter pylori test-and-treat strategy as an initial management approach to functional dyspepsia in Korea, suggesting the need for early endoscopic evaluation. Additional studies are necessary to adjust the cutoff age for implementation of immediate endoscopic evaluation of patients without alarm symptoms. Considering the prevalence of H. pylori infection and the limited efficacy of symptomatic relief after its eradication, further well-qualified studies in Korea are warranted.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Dyspepsia/diagnosis , Early Diagnosis , Endoscopy, Gastrointestinal , Helicobacter Infections/diagnosis , Helicobacter pylori/pathogenicity , Humans , Predictive Value of Tests , Prevalence , Prognosis , Surveys and Questionnaires , Republic of Korea/epidemiology , Risk Factors
14.
Rev. gastroenterol. Perú ; 33(1): 9-27, ene.-mar. 2013. ilus, tab
Article in Spanish | LILACS, LIPECS | ID: lil-692416

ABSTRACT

Objetivos: Validación del cuestionario SODA (severity of dyspepsia assessment) para evaluar la severidad de los síntomas en pacientes con dispepsia. Materiales y métodos: Se evaluó la validez de contenido y de apariencia, tras lo cual se elaboró un cuestionario modificado. Posteriormente se evaluó la consistencia interna, la validez de constructo y la sensibilidad al cambio. Resultados: Se obtuvo una validez de contenido y de apariencia adecuadas. Se obtuvo un α-Cronbach del cuestionario y por componentes superiores a 0,7. Al analizar la validez de constructo, la correlaciσn entre los valores del cuestionario SODA modificado y SF-36 fue de -0,72 (p<0,001) a través de la prueba de Pearson. Al evaluar la correlación entre el puntaje del cuestionario SODA modificado y el de percepción subjetiva de los síntomas se obtuvo un valor de 0,72 (p<0,001) mediante la prueba de Spearman. Se comparó las medias de los puntajes del cuestionario SODA modificado pre y post-tratamiento mediante la prueba de T-Student en el que se encontró una diferencia significativa (p<0,001) con un promedio de caída de 5,70±5,33. Conclusiones: El cuestionario SODA modificado cumple con los criterios de validez por lo que sirve para valorar la severidad de la dispepsia y su evolución.


Objectives: To validate SODA (severity of dyspepsia assessment) questionnaire in our population for evaluating symptoms severity in patients with dyspepsia. Materials and methods: Content and appearance validity were measured, and then a modified questionnaire was developed. A pilot test was made and reliability, construct validity and responsiveness were measured. Results: An adequate content and appearance validity were obtained. On the pilot test, reliability of the complete questionnaire and by components had Cronbach alpha values over 0,7. Construct validity of SODA was evaluated by correlating modified SODA results with SF-36 scores using Pearson test: -0.72 (p<0.001). When we compared results of modified SODA questionnaire and the score of a question about subjective perception of the disease using Spearman test we obtained similar results: 0.72 (p<0.001). Two means of SODA questionnaire scores, before and after treatment, were compared using Student’s T test, and a significant difference was found, (p<0.001) with a drop mean of 5.70 5.33. Conclusion: Modified SODA questionnaire meets all criteria of validity and it could be used to measure dyspepsia severity and its evolution in a Peruvian population.


Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Dyspepsia/diagnosis , Surveys and Questionnaires , Symptom Assessment , Peru , Severity of Illness Index
15.
Rev. gastroenterol. Perú ; 33(1): 28-33, ene.-mar. 2013. ilus, tab
Article in Spanish | LILACS, LIPECS | ID: lil-692417

ABSTRACT

Objetivo: Identificar las características clínicas, endoscópicas e histológicas así como su relación con Helicobacter pylori (Hp) en pacientes atendidos con el diagnóstico de dispepsia en nuestro hospital durante el año 2010. Materiales y métodos: Estudio descriptivo, transversal y retrospectivo en la población que acudía a nuestro hospital, en el año 2010, tamaño muestral de 300 pacientes. Se evaluaron variables clínicas, histológicas y endoscópicas. Se confeccionó un instrumento de recolección de datos. Utilizamos el paquete estadístico SPSS 15.0. Resultados: Del total, en su mayoría fueron mujeres (63%), la edad media de 42 años, procedentes del distrito de SJL (30%), 50% de origen andino. El 19% presentaba signos de alarma, la baja de peso caracterizó a este grupo (14%), en endoscopía, se observó eritema antral (74,7%), erosiones (32,9%) y nodularidad (22%). El 93% presentó infección por Hp, displasia leve en el 2,7% y atrofia en solo 14,7%.El 98,5% de los pacientes que presentó nodularidad tuvo infección por Hp. Conclusiones: Los síntomas dispépticos frecuentes fueron dolor epigástrico seguido de distensión abdominal, el género femenino lo presentó con mayor frecuencia, signos de alarma fueron poco frecuentes, eritema antral fue la característica más encontrada en las endoscopías. La gastritis crónica moderada fue el diagnóstico anátomo-patológico mas frecuente. La infección por Hp tuvo asociación significativa con nodularidad y eritema antral así como también con actividad de la gastritis.


Objective: To identify clinical, endoscopic and histological characteristics and their relationship with Helicobacter pylori (Hp) in patients treated with the diagnosis of dyspepsia in our hospital during 2010. Materials and methods: We conducted a cross sectional and retrospective study in the population attending our hospital during 2010, a sample of 300 patients was studied. We evaluated clinical, histological and endoscopic findings. An instrument of data collection was made. We used the statistical package SPSS 15.0. Results: It was found that the majority were female (63%), while the mean age at diagnosis was 42 years, mostly from SJL district (30%) of these Andean origin (50 %) was the highest percentage. Only 19% showed signs of alarm, low weight characterize this group (14%), the endoscopic findings most commonly found were antral erythema (74.7%), followed by erosions (32.9%) and nodules (22%). Hp infection was found in 93%, mild dysplasia was present in 2.7% and atrophy in only 14.7%. The 98.5% of patients with nodularity on endoscopy had Hp infection. Conclusions: The most frequent dyspeptic symptoms were epigastric pain followed by abdominal distension, the female gender was present more often, the warning signs were rare, antral erythema was the feature most found in endoscopies. Hp infection was significantly associated with some features such as endoscopic antral nodularity and erythema as well as had relation to the activity of gastritis.


Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Dyspepsia/diagnosis , Endoscopy, Gastrointestinal , Cross-Sectional Studies , Dyspepsia/pathology , Hospitals , Peru , Retrospective Studies
16.
Arab Journal of Gastroenterology. 2013; 14 (4): 165-168
in English | IMEMR | ID: emr-187169

ABSTRACT

Background and study aims: Recent studies have shown that the high prevalence and the various clinical presentations of gastro-oesophageal reflux disease [GERD] and dyspepsia impose an enormous economic burden on society. Economic cost data have unique characteristics: they are counts, and they have zero inflation. Therefore, these data require special models. Poisson regression [PR], negative binomial regression [NB], zero inflated Poisson [ZIP] and zero inflated negative binomial [ZINB] regression are the models used for analysing cost data in this paper


Patients and methods: In this study, a cross-sectional household survey was distributed to a random sample of individuals between May 2006 and December 2007 in the Tehran province of Iran to determine the prevalence of gastrointestinal symptoms and disorders and their related factors. The cost associated with each item was calculated. PR, NB, ZIP and ZINB models were used to analyse the data. The likelihood ratio test and the Voung test were used to conduct pairwise comparisons of the models. The log likelihood, the Akaike information criterion [AIC] and the Bayesian information criterion [BIC] were used to compare the performances of the models


Results: According to the likelihood ratio test and the Voung test and all three criteria used to compare the performance of the models, ZINB regression was identified as the best model for analysing the cost data. Sex, age, smoking status, BMI, insurance status and education were significant predictors


Conclusion: Because the NB model demonstrated a better fit than the PR and ZIP models, over-dispersion was clearly only due to unobserved heterogeneity. In contrast, according to the likelihood ratio test, the ZINB model was more appropriate than the ZIP model. The ZINB model for the cost data was more appropriate than the other models


Subject(s)
Dyspepsia/diagnosis , Costs and Cost Analysis/economics , Statistics , Gastroesophageal Reflux/epidemiology , Dyspepsia/epidemiology
17.
Acta méd. (Porto Alegre) ; 33(1): [7], 21 dez. 2012.
Article in Portuguese | LILACS | ID: biblio-881599

ABSTRACT

Dispepsia Funcional é a causa mais frequente das dispepsias. Sua fisiopatologia permanece obscura e ainda não dispomos de um método diagnóstico específico. Além disso, há uma ampla lista de diagnósticos diferenciais de doenças as quais também cursam com dispepsia. O tratamento muitas vezes tem benefícios discretos, e deve ser individualizado sempre que possível, juntamente com uma boa abordagem psicossocial, a qual pode auxiliar na terapêutica e no manejo destes pacientes.


Funcional Dyspepsia is the most frequent cause of dyspepsia. Its pathophysiology remains unclear and there is not still a specific diagnostic method. Moreover, there is an extensive list of differential diagnosis of diseases which also presents with dyspepsia. The treatment often has discrete benefits and must be individually whenever possible, with good psychosocial, which can aid in the treatment and the management of these patients.


Subject(s)
Dyspepsia/diagnosis , Dyspepsia/physiopathology , Dyspepsia/therapy
18.
GEN ; 66(3): 147-150, sep. 2012. ilus, tab
Article in Spanish | LILACS | ID: lil-664535

ABSTRACT

Introducción: la duodenitis es una condición frecuente, con el desarrollo de la endoscopia digestiva se han propuesto diferentes nomenclaturas para su descripción, sin una efectiva unanimidad de conceptos y la asociación clínica-histopatológica no está clara. Objetivo: evaluar la correlación endoscópica e histopatológica de la duodenitis en pacientes ambulatorios con síntomas de dispepsia. Pacientes y métodos: estudio descriptivo, prospectivo, de corte transversal y analítico. Se realizó endoscopia digestiva superior diagnóstica a 39 pacientes con síntomas de dispepsia de la consulta de Gastroenterología, con toma de muestra de mucosa duodenal para análisis histopatológico. Se estableció el grado de duodenitis según clasificación endoscópica ajustada (Sistema Sydney) y se determinó la correlación entre el grado de duodenitis endoscópica y el diagnóstico histopatológico. Resultados: se incluyeron 32 pacientes, 18 femeninos (56,25%) y 14 masculinos (43,75%). La media de edad fue 47,5 ±15,4 años; el síntoma predominante fue Epigastralgia (59,36%). Hubo concordancia de 100% entre las anormalidades endoscópicas y las alteraciones histopatológicas (p <0,01). Se obtuvo una sensibilidad de las alteraciones endoscópicas frente a las histopatológicas de 97% con especificidad de 100%. La relación entre los hallazgos endoscópicos y el reporte histopatológico fue estadísticamente significativa, p < 0,01, con una correlación positiva sustancial alta, c= 0,74. Conclusión: la endoscopia digestiva superior permitió evaluar y clasificar correctamente la presencia de duodenitis, con una alta correlación con el diagnóstico histopatológico.


Introduction: Duodenitis is a common condition, with the development of digestive endoscopy different nomenclatures have been proposed for their description, without an effective unanimity of concepts and the clinic-histopathological association is unclear. Objective: Evaluate the endoscopic and histopathological correlation of duodenitis in ambulatory patients with symptoms of dyspepsia. Patients and methods: Descriptive, prospective, cross-sectional and analytical study. Upper digestive diagnostic endoscopy was performed in 39 patients with symptoms of dyspepsia of the Gastroenterology consultation, with sampling of the duodenal mucosa for histopathological analysis. The degree of duodenitis was established according the adjusted endoscopic classification (Sydney System) and the correlation between the degree of endoscopic duodenitis and the histopathological diagnosis was determined. Results: 32 patients were included, 18 female (56.25%) and 14 male (43.75%). The mean age was 47.5 ± 15.4 years; the predominant symptom was Epigastric pain (59.36%). There was 100% concordance between the endoscopic abnormalities and the histopathological alterations (p < 0.01). The sensitivity of the endoscopic alterations compared to the histopathological was 97% and the specificity 100%. The relation between the endoscopic findings and the histopathological report was statistically significant, p < 0.01, with a high positive substantial correlation, c = 0.74. Conclusion: Upper digestive endoscopy allowed evaluate and correctly classify the presence of duodenitis, with a high correlation with the histopathological diagnosis.


Subject(s)
Humans , Male , Female , Dyspepsia/complications , Dyspepsia/diagnosis , Duodenitis/pathology , Duodenitis , Endoscopy, Digestive System/methods , Histological Techniques/methods , Gastroenterology
19.
Gastroenterol. latinoam ; 23(2): S83-S86, abr.-jun. 2012. tab
Article in Spanish | LILACS | ID: lil-661623

ABSTRACT

Gastroparesis corresponds to the clinical picture of a non-obstructive alteration in gastric emptying. The most common causes are idiopathic, postsurgical and diabetes mellitus. Endoscopy and gastric emptying scintigraphy are necessary for diagnosis. Fractionating the diet and avoiding fat are recommended actions. Prokinetics are fundamental in gastroparesis therapy. Domperidone is the first choice because it has a better safety profile. It is advisable to rotate prokinetics. In refractory cases it is suggested to try other prokinetics (such as erythromycin or prucalopride), effective management of nausea and nutrition optimization. In selected cases, therapies such as electrical stimulation could be evaluated. Functional dyspepsia is defined as symptoms that probably originate in the gastroduodenal region, having ruled out other possibilities. Therefore, endoscopy should show no alterations that could explain the symptoms. The most frequently encountered pathophysiological alterations are slow gastric emptying, impaired accommodation and hypersensitivity. None has been linked unequivocally to a pattern of symptoms. It is suggested to start with proton-pump inhibitors therapy. In refractory cases, prokinetics should be added. If there is no adequate response, 24-hour pH monitoring and gastric emptying should be ordered. In case of altered gastric emptying, adjust prokinetics. If gastric emptying is normal, bupirone or mianserin could be used.


La gastroparesia corresponde a un cuadro clínico debido a mal vaciamiento gástrico no obstructivo del estómago. Sus causas más frecuentes son idiopática, diabetes mellitus y postquirúrgica. La endoscopia y el cintigrama de vaciamiento gástrico son necesarios para el diagnóstico. Se recomienda fraccionar la dieta y evitar las grasas. Los procinéticos son fundamentales en el tratamiento de la gastroparesia. La domperidona es la primera opción por su mejor perfil de seguridad. Es aconsejable rotar los procinéticos. En casos refractarios se puede intentar otros procinéticos (como eritromicina o prucalopride), manejar específicamente las náuseas y optimizar la nutrición. En casos seleccionados se puede intentar terapias como estimulación eléctrica. La dispepsia funcional está definida por síntomas que probablemente se originan en la región gastroduodenal, habiendo descartado otras posibilidades. Por esto, requiere un estudio endoscópico sin alteraciones que expliquen los síntomas. Los hallazgos fisiopatológicos más frecuentemente encontrados son alteraciones del vaciamiento gástrico, trastornos de la acomodación e hipersensibilidad. Ninguno de ellos ha sido asociado inequívocamente a algún patrón de síntomas. Se sugiere iniciar tratamiento con inhibidores de la bomba de protones. En casos refractarios, es aconsejable agregar procinéticos. Si no hay adecuada respuesta, se sugiere estudiar con una ph-metría de 24 horas y vaciamiento gástrico. En caso de vaciamiento alterado, ajustar los procinéticos. En caso de vaciamiento normal, se sugiere uso de buspirona o mianserina.


Subject(s)
Humans , Dyspepsia/diagnosis , Dyspepsia/therapy , Gastroparesis/diagnosis , Gastroparesis/therapy , Gastroparesis/classification , Gastroparesis/etiology
20.
Article in Korean | WPRIM | ID: wpr-21291

ABSTRACT

BACKGROUND/AIMS: We aimed to estimate the proportion of significant endoscopic findings and their association with dyspeptic symptoms and to evaluate the predictors for significant endoscopic findings. METHODS: Total of 3,872 subjects (58.3% men, mean age 43.6+/-9.3 years) who had undergone endoscopy were enrolled at the health promotion center. Each subject completed validated questionnaires, including data on gastrointestinal symptoms, socio-demographic history and medical history. Significant endoscopic findings were included peptic ulcer disease, reflux esophagitis, gastric cancer, Barrett's esophagus and gastro-duodenal erosions. Multiple logistic regression models were used to assess the predictors for significant endoscopic findings. RESULTS: The proportion of significant endoscopic findings was 39.1%. There was no significant difference of endoscopic findings between the dyspepsia and asymptomatic group (41.0% vs. 37.4%, p>0.05). There was no difference of the incidence of reflux esophagitis or peptic ulcer between subjects with and without dyspepsia. Peptic ulcer was more frequently present in subjects with reflux symptoms than asymptomatic subjects (12.3% vs. 9.0%, p=0.03). Male gender (odds ratio [OR], 3.91; 95% confidence interval [CI], 3.18-4.81) increased the risk for having endoscopic abnormality and having symptoms of functional dyspepsia according to Rome III criteria (OR, 0.75; 95% CI, 0.57-0.97) significantly decreased this risk. CONCLUSIONS: About 40% of subjects with dyspepsia had abnormal endoscopic findings, and the dyspepsia symptoms may not predict the significant endoscopic findings. Diagnostic criteria of functional dyspepsia by Rome III may be useful to predict not having significant upper endoscopic findings.


Subject(s)
Adult , Aged , Aged, 80 and over , Dyspepsia/diagnosis , Female , Gastroesophageal Reflux/diagnosis , Gastroscopy , Humans , Logistic Models , Male , Middle Aged , Multivariate Analysis , Odds Ratio , Peptic Ulcer/diagnosis , Postprandial Period , Predictive Value of Tests , Surveys and Questionnaires , Severity of Illness Index , Sex Factors , Upper Gastrointestinal Tract/pathology , Young Adult
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