Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 182
Filter
1.
Más Vita ; 3(2): 40-48, jun 2021.
Article in Spanish | LILACS, LIVECS | ID: biblio-1253892

ABSTRACT

La diabetes es una enfermedad que afecta a la población mundial, y los adultos mayores son los más propenso a padecerla, como consecuencia a los niveles de estrés y malos hábitos alimenticios que llevaron a lo largo de su vida productiva. Es por ello, que el: Objetivo de esta investigación es, describir los factores asociados al autocuidado de la salud en los pacientes diabéticos. Materiales y métodos: Investigación documental. Se incluyeron estudios de cohortes que analizaron diagnóstico y tratamiento oportuno en el autocuidado de pacientes diabéticos en bases de datos electrónicas, como lo son Porta Scielo, PubMed, Medline PLUS, Embase, Scopus y Web of Science, del 2015 al 2020. Las medidas de autocuidado son habilidades que los individuos practican para el mantenimiento de su salud, sobre todo cuando hay una patología de base que ponga en riesgo el estado de salud y el bienestar en general. Resultado: La diabetes es una enfermedad complicada, requiere vigilancia constante, conocimiento de la enfermedad y del apoyo de varios especialistas en salud, la mayor parte del cuidado y control debe prevenir del paciente mismo. Es importante que los pacientes no solo perciban los daños o la severidad de la ausencia de autocuidado, lo que puede influir en el adecuado control de la diabetes mellitus, sino que se le proporcione mediante la educación para la salud, estrategias que faciliten en ellos el aprendizaje de habilidades que le permitan percibir los beneficios de la adopción de estilos de vida saludables. Conclusiones: el equipo básico de salud desempeña un rol importante en la realización de acciones que faciliten el autocuidado en los pacientes diabéticos, lo que puede constituir una vía para que las personas tomen decisiones serias respecto al mantenimiento de un adecuado estado de su salud. Por ende, es necesario que se realicen programas que desarrollen el ajuste adecuado de expectativas, objetivos definidos, el manejo adecuado del refuerzo, el incremento del sentimiento de autoeficacia, el autocontrol, y que brinden alternativas que favorezcan un autocuidado óptimo(AU)


Diabetes is a disease that affects the world population, and older adults are the most prone to suffer from it, as a consequence of the levels of stress and poor eating habits that they led throughout their productive lives. That is why the: Objective of this research is to describe the factors associated with self-care of health in diabetic patients. Materials and methods: Documentary research. Cohort studies that analyzed diagnosis and timely treatment in the self-care of diabetic patients were included in electronic databases, such as Porta Scielo, PubMed, Medline PLUS, Embase, Scopus and Web of Science, from 2015 to 2020. The measures of Self-care are skills that individuals practice to maintain their health, especially when there is an underlying pathology that puts the state of health and well-being in general at risk. Result: Diabetes is a complicated disease, it requires constant vigilance, knowledge of the disease and the support of various health specialists, most of the care and control must be prevented by the patient himself. It is important that patients not only perceive the damage or the severity of the absence of self-care, which can influence the adequate control of diabetes mellitus, but that it is provided through health education, strategies that facilitate in them the learning skills that allow you to perceive the benefits of adopting healthy lifestyles. Conclusions: the basic health team plays an important role in carrying out actions that facilitate self-care in diabetic patients, which can constitute a way for people to make serious decisions regarding the maintenance of an adequate state of their health. Therefore, it is necessary to carry out programs that develop the adequate adjustment of expectations, defined objectives, the adequate management of reinforcement, the increase of the feeling of self-efficacy, self-control, and that provide alternatives that favor a more optimal self-care(AU)


Subject(s)
Humans , Male , Female , Self Care , Diabetes Mellitus , Endocrine System , Metabolic Diseases , Public Health , Risk Factors , Feeding Behavior
2.
Rev. chil. endocrinol. diabetes ; 14(3): 133-138, 2021. tab
Article in Spanish | LILACS | ID: biblio-1293389

ABSTRACT

El uso de opioides ha aumentado en forma significativa en las últimas décadas, lo que nos ha permitido conocer sus diversos efectos en el sistema endocrino. Estos efectos están sub diagnosticados, en parte porque los síntomas se confunden con los de la misma enfermedad que lleva al uso de opioides y porque no los buscamos de forma dirigida. El hipogonadismo y la insuficiencia suprarrenal son sus efectos más establecidos, sin embargo, otros efectos como los provocados en el tejido óseo requieren de especial atención. La evaluación de los ejes gonadotropo, adrenal y de la salud ósea debe tenerse en consideración en los usuarios crónicos de opioides, particularmente frente a la presencia de síntomas. La suspensión o reducción del uso de opioides es el primer tratamiento del compromiso endocrinológico.


The use of opioids has increased significantly in recent decades, which has allowed us to understand its effects on the endocrine system. These effects are underdiagnosed, the symptoms are confused with those of the same disease that leads to the use of opioids and we do not look for them in a targeted way. Hypogonadism and adrenal insufficiency are its most established effects, however, other effects such as the ones caused on bone tissue require special attention. Evaluation of gonadotropic and adrenal axes as well as bone health should be taken into consideration in chronic opioid users, particularly in the presence of symptoms. Stopping or reducing opioid use is the first treatment for endocrine compromise.


Subject(s)
Humans , Endocrine System Diseases/chemically induced , Endocrine System/drug effects , Analgesics, Opioid/adverse effects , Adrenal Insufficiency/chemically induced , Hypogonadism/chemically induced
4.
Rev. cient. Esc. Univ. Cienc. Salud ; 6(2): 49-60, jun.-dic. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1117911

ABSTRACT

Recientemente se ha descubierto que el tejido adiposo (TA) tiene una crucial influencia sobre diversos procesos fisiológicos a través de la secreción de múltiples factores endocrinos, paracrinos y autocrinos, conocidos como adipoquinas. Desde su descubrimiento, a gran parte de las adipoquinas se les ha atribuido un importante papel en el metabolismo energético, regulando el almacenaje y producción de triglicéridos y colesterol. Uno de los descubrimientos más importantes sobre las funciones del tejido adiposo es como el aumento de su tamaño estimula la secreción de citocinas con carácter pro-inflamatorio, influyendo así en el control de su propia celularidad, la angiogénesis y la migración de células inmunes. Estudios recientes han mostrado como, ante cambios en la homeostasia, el tejido adiposo puede modificar los procesos de coagulación y fibrinólisis. La participación del tejido adiposo en la vascularización y la angiogénesis ha dado nuevos y reveladores resultados, centrados en nuevas adipoquinas como la quemerina y la monobutirina. El estudio de las adipoquinas y su gama de efectos sobre el organismo amplían cada vez más el panorama de las funciones del tejido adiposo y su importancia en el control del metabolismo y la homeostasia. Considerando toda la nueva información disponible, esta revisión bibliográfica busca enumerar, describir y analizar las principales funciones endocrinas del TA. La metodología utilizada para ello consistió en una revisión bibliográfica de tipo descriptivo realizada mediante la revisión sistemática de artículos científicos, consultando diversas bases de datos. Finalmente, se seleccionaron 30 artículos de los útimos cinco años, en español e inglés...(AU)


Subject(s)
Humans , Adipose Tissue , Endocrine System/physiopathology , Triglycerides , Adipokines
5.
Bol. méd. postgrado ; 35(1): 21-24, Ene-Jun. 2019.
Article in Spanish | LILACS, LIVECS | ID: biblio-1120636

ABSTRACT

Con el objetivo de identificar hallazgos ecográficos en el parénquima tiroideo en el personal ocupacionalmente expuesto y no expuesto a radiación ionizante (RI) del Hospital Central Universitario Dr. Antonio María Pineda, se realizó un estudio descriptivo transversal con una muestra de 45 individuos expuestos a RI del Servicio de Radiología y Diagnóstico por Imágenes Dr. Theoscar Sanoja Hernández y 38 individuos de los Servicios de Traumatología y Ortopedia y Medicina Física y Rehabilitación que no están expuestos a RI obteniendo que el 63% del personal expuesto presentaron algún tipo de alteración en el ultrasonido tiroideo en comparación con el 43% del personal no ocupacionalmente expuesto; los hallazgos más frecuentes en el personal expuesto fueron bocio difuso (44%), nódulos (32%) y quistes (24%) mientras que en el personal no expuesto fueron quistes (38%), bocio difuso (19%) y nódulos (19%). Estos hallazgos permiten concluir que el porcentaje del personal con afectación de la glándula tiroides fue mayor en personal expuesto y que los hallazgos ecográficos difieren entre los grupos estudiados(AU)


In order to identify ultrasound findings in thyroid parenchyma of hospital staff exposed and not exposed to ionizing radiation (IR) of the Hospital Central Universitario Dr. Antonio Maria Pineda, we performed a cross-sectional descriptive study with a sample of 45 individuals exposed to IR who worked in the Servicio de Radiología y Diagnóstico por Imágenes Dr. Theoscar Sanoja Hernández and 38 individuals who worked at the Servicios de Traumatología y Ortopedia y Medicina Física y Rehabilitación and were not exposed. The results showed that 63% of the exposed group had ultrasound thyroid findings in contrast to 43% of the non-exposed group. The most common findings in the exposed group were diffuse goiter (44%), nodules (32%) and cysts (24%) and in the non-exposed group were cysts (38%), diffuse goiter (19%) y nodules (19%). These findings show that ultrasound thyroid findings was higher in exposed hospital staff and that the type of thyroid disease differ among both groups(AU)


Subject(s)
Humans , Male , Female , Radiation, Ionizing , Thyroid Gland , Thyroid Hormones , Ultrasonography , Diagnostic Imaging , Endocrine System , Parenchymal Tissue/pathology
6.
Rev. chil. nutr ; 46(2): 205-214, abr. 2019. tab
Article in Spanish | LILACS | ID: biblio-1003695

ABSTRACT

RESUMEN El lactosuero es un subproducto derivado de la elaboración de queso. La calidad de la composición química de las proteínas del lactosuero las convierte en un sustrato ideal para la generación de péptidos con actividad biológica. La presente revisión tiene por objetivo analizar y discutir los efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero (PBDL) en la salud. Asimismo, este trabajo muestra detalladamente las estructuras químicas de las secuencias de los PBDL capaces de ejercer efectos favorables in vitro e in vivo e influir positivamente en los sistemas cardiovascular, endócrino e inmunológico. Sin embargo, las metodologías para generar PBDL de manera controlada, la dosificación y las concentraciones óptimas han sido poco exploradas. Por lo que es importante llevar a cabo investigación de frontera que permita avanzar el umbral del conocimiento vislumbrando la posibilidad de utilizar los PBDL como coadyuvantes en la prevención y tratamiento de enfermedades.


ABSTRACT Whey is a by-product of cheese production. The relevant chemical composition of whey proteins makes them an ideal substrate to release peptides with biological activity. The objective of this manuscript was to analyze and discuss the effects of whey-derived proteins bioactive peptides in health. Moreover, this review shows in detail sequences able to benefit human systems. Several in vitro and in vivo studies showed the capacity of these bioactive peptides to positively influence cardiovascular, endocrine and immune systems. However, the methodologies to obtain them in a controlled way, as well as dose and optimum concentrations have been scarcely explored. Therefore, it is necessary to conduct new research to improve knowledge that focuses on the possibility of using whey-derived bioactive peptides in the prevention and treatment of diseases.


Subject(s)
Humans , Peptides , Cardiovascular System , Proteins , Impacts on Health , Endocrine System , Whey , Immune System
7.
Article in English | WPRIM | ID: wpr-763706

ABSTRACT

In the current era of effective antiretroviral therapies (ARTs), human immunodeficiency virus (HIV) infection became a chronic disorder that requires long term follow-up. Among other medical issues, these patients may develop endocrine problems, specific to HIV infection and its treatment. The purpose of this review is to give an overview of common endocrine complications associated with HIV infection, and to propose diagnostic and therapeutic strategies. HIV can affect the endocrine system at several levels. Adrenal and gonadal dysfunction, osteoporosis with increased fracture risk, dyslipidemia with increased cardiovascular risk, are some of the endocrine disorders prevalent in HIV-infected patients that may negatively influence quality of life, and increase morbidity and mortality. While ARTs have dramatically increased life expectancy in the HIV-infected population, they are not devoid of adverse effects, including endocrine dysfunction. Physicians caring for HIV-infected patients should be knowledgeable and exercise a high index of suspicion for the diagnosis of endocrine abnormalities, and in particular be aware of those that can be life threatening. Endocrine evaluation should follow the same strategies as in the general population, including prevention, early detection, and treatment.


Subject(s)
Anti-Retroviral Agents , Diabetes Mellitus , Diagnosis , Dyslipidemias , Endocrine System Diseases , Endocrine System , Follow-Up Studies , Gonads , HIV Infections , HIV , HIV-Associated Lipodystrophy Syndrome , Humans , Hyperlipidemias , Life Expectancy , Mortality , Osteoporosis , Quality of Life
8.
Article in English | WPRIM | ID: wpr-763702

ABSTRACT

Abnormal production of thyroid hormone is one of the common endocrine disorders, and thyroid hormone production declines with age. The aging process also negatively affects the immune system. An interaction between endocrine system and the immune system has been proposed to be bidirectional. Emerging evidence suggests an interaction between a lymphocyte population, called natural killer (NK) cells and thyroid gland function. Here, we review the relationship between NK cells and thyroid function and disease.


Subject(s)
Aging , Endocrine System , Immune System , Immunotherapy , Killer Cells, Natural , Lymphocytes , Thyroid Diseases , Thyroid Gland , Thyroiditis
9.
Singapore medical journal ; : 140-144, 2019.
Article in English | WPRIM | ID: wpr-776999

ABSTRACT

INTRODUCTION@#Epidural steroid injections are an integral part of nonsurgical management of radicular pain from lumbar spine disorders. We studied the effect of dexamethasone 8 mg epidural injections on the hypothalamic-pituitary-adrenal axis and serum glucose control of Asian patients.@*METHODS@#18 patients were recruited: six diabetics and 12 non-diabetics. Each patient received a total of dexamethasone 8 mg mixed with a local anaesthetic solution of lignocaine or bupivacaine, delivered into the epidural space. Levels of plasma cortisol, adrenocorticotropic hormone (ACTH), serum glucose after an overnight fast and two-hour postprandial glucose, as well as weight, body mass index, blood pressure and heart rate were measured within one week prior to the procedure (baseline) and at one, seven and 21 days after the procedure.@*RESULTS@#Median fasting blood glucose levels were significantly higher on post-procedure Day 1 than at baseline. However, there was no significant change in median two-hour postprandial blood glucose from baseline levels. At seven and 21 days, there was no significant difference in fasting or two-hour postprandial glucose levels. Both ACTH and serum cortisol were significantly reduced on Day 1 compared to baseline in all patients. There was no significant difference in ACTH and serum cortisol levels from baseline at Days 7 and 21.@*CONCLUSION@#Our study shows that epidural steroid injections with dexamethasone have a real, albeit limited, side effect on glucose and cortisol homeostasis in an Asian population presenting with lower back pain or sciatica.


Subject(s)
Adrenocorticotropic Hormone , Blood , Adult , Aged , Blood Glucose , Body Mass Index , Dexamethasone , Therapeutic Uses , Diabetes Mellitus , Therapeutics , Endocrine System , Female , Glucocorticoids , Humans , Hydrocortisone , Blood , Hypothalamo-Hypophyseal System , Injections, Epidural , Methods , Male , Middle Aged , Pituitary-Adrenal System , Postprandial Period , Singapore , Young Adult
10.
Article in English | WPRIM | ID: wpr-764042

ABSTRACT

Among the environmental chemicals that may be able to disrupt the endocrine systems of animals and humans are polychlorinated biphenyls (PCBs), a chemical class of considerable concern. PCB consists of two six-carbon rings linked by a single carbon bond, and theoretically, 209 congeners can form, depending on the number of chlorines and their location on the biphenyl rings. Furthermore, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) exposure also increases nitric oxide production and nuclear factor kappa-light-chain-enhancer of activated B cells binding activity in chondrocytes, thus contributing as an initiator of chondrocyte apoptosis and resulting in thymic atrophy and immunosuppression. This study identified whether cardiac and immune abnormalities from PCB126 were caused by the Kv1.3 and Kv1.5 channels. PCB126 did not affect either the steady-state current or peak current of the Kv1.3 and Kv1.5 channels. However, PCB126 right-shifted the steady-state activation curves of human Kv1.3 channels. These results suggest that PCBs can affect the heart in a way that does not block voltage-dependent potassium channels including Kv1.3 and Kv1.5 directly.


Subject(s)
Animals , Apoptosis , Atrophy , B-Lymphocytes , Carbon , Chondrocytes , Endocrine System , Heart , Humans , Immunosuppression , Nitric Oxide , Polychlorinated Biphenyls , Potassium Channels
11.
Article in English | WPRIM | ID: wpr-763365

ABSTRACT

Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.


Subject(s)
Consensus , Endocrine Disruptors , Endocrine System , Humans , Male , Oxidative Stress , Spermatozoa
12.
Pesqui. vet. bras ; 38(1): 119-128, Jan. 2018. tab, ilus
Article in Portuguese | ID: biblio-895537

ABSTRACT

Foram estudadas as adrenais de 300 cães submetidos à necropsia no Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria, no período de março de 2012 a junho de 2013. Os tecidos coletados foram fixados em formol 10% e encaminhados ao processamento his­tológico de rotina para confecção e análise de lâminas histológicas. Posteriormente, foram revisados os protocolos de necropsia e dados epidemiológicos referentes aos cães que tiveram as adrenais coletadas foram anotados. Dos 300 cães analisados, 82% tinham uma ou mais alterações nas adrenais, que foram classificadas de acordo com a patogênese e a prevalência. Lesões hiperplásicas foram as mais prevalentes, com 91,5% das ocorrências, seguido de lesões degenerativas (26,%), circulatórias (20,3%), neoplásicas (15%), inflamatórias (4,1%) e outras lesões (14,2%). Macroscopicamente, as hiperplasias caracterizavam-se por variável quantidade de nódulos brancacentos, de até 1,5cm de diâmetro. Em 72,9% dos casos de hiperplasia, os nódulos eram constituídos de células da camada glomerulosa. A maioria dos animais que apresentou lesões hiperplásicas era constituída de fêmeas (60,4%), idosos (46,9%) e cães com raça definida (55,6%). A degeneração gordurosa foi a lesão degenerativa mais prevalente (54,7%) e era caracterizada por células da zona fasciculada e da zona reticular com grandes vacúolos citoplasmáticos. Entre as alterações neoplásicas, tumores primários foram mais prevalentes (75,7%), com predomínio de adenomas (57,1%), seguido de feocromocitomas (25%) e carcinomas corticais (17,9%). Os tumores metastáticos perfizeram 24,3% dos casos de alterações neoplásicas. As adrenais foram sítio de metástase de carcinoma mamário, osteossarcoma, melanoma, linfoma, colangiocarcinoma, sarcoma histiocítico e adenocarcinoma pulmonar. No item "outras lesões", adrenal de estresse foi a alteração mais prevalente (37,1%). Essa alteração era caracterizada histologicamente por córtex de aspecto variegado, com áreas de fina vacuolização citoplasmática das células da camada fasciculada, intercaladas por grupos de células hipereosinofílicas. Este estudo possibilitou concluir que lesões nas adrenais de cães são extremamente frequentes, de modo que a avaliação cuidadosa desse órgão se faz necessária na rotina de diagnóstico em patologia.(AU)


The adrenal glands of 300 dogs, underwent to necropsy in the Laboratório de Patologia Veterinária at the Universidade Federal de Santa Maria (LPV/UFSM), were studied from March 2012 to June 2013. The collected tissues were fixed in 10% buffered formalin and sent to the routine histological processing in order to preparation and analysis of histological slides. Subsequently, it was reviewed the necropsy reports and the epidemiological data of the dogs which had the adrenal glands collected. Out of the 300 dogs examined, 82% had one or more adrenal lesions that were classified according to the pathogenesis and prevalence. The hyperplastic lesions were the most prevalent, comprising 91.5% of the cases, followed by degenerative (26%), circulatory (20.3%), neoplastic (15%), inflammatory (4.1%) and other lesions (14.2%). Grossly, hyperplasia was characterized by a variable amount of whitish nodules, ranging from 0.2-1.5 cm of diameter. In 72.9% of the hyperplasia cases, the nodules were composed by cells of the glomerulosa zone. Most of the animals that showed hyperplastic lesions consisted of females (60.4%), elderly (46.9%) and purebred dogs (55.6%). Fatty degeneration was the most prevalent degenerative lesions (54.7%), characterized by cells of the fasciculata and reticularis zones with large cytoplasmic vacuoles. Among the neoplastic changes, primary tumors were the most prevalent (75.7%), with predominance of adenomas (57.1%), followed by pheochromocytomas (25%) and cortical carcinomas (17.9%). Metastatic tumors corresponded to 24.3% of all cases of neoplastic changes. The adrenal glands were the site of metastasis of mammary gland carcinoma, osteosarcoma, melanoma, lymphoma, cholangiocarcinoma, histiocytic sarcoma and lung adenocarcinoma. Under "other lesions", adrenal of stress was the most prevalent change (37.1%). It was characterized histologically by a cortex with irregular appearance, with areas of mild cell vacuolation in the fasciculata zone, interspersed with hypereosinophilic cell groups. This study allowed the conclusion that the lesions in adrenal glands of dogs are extremely common, highlighting the importance of a careful evaluation of this organ in the routine of pathological diagnostic.(AU)


Subject(s)
Animals , Dogs , Adrenal Glands/injuries , Endocrine System/pathology , Adrenal Gland Neoplasms/veterinary , Epidemiologic Studies
13.
Arq. Inst. Biol ; 85: e1022017, 2018. tab, graf
Article in English | ID: biblio-999077

ABSTRACT

Bisphenol-A is currently considered an environmental pollutant, capable of interfering in the endocrine system of organisms and causing alterations in its development and reproductive system. An alternative method to the chemical treatment of this pollutant has been the use of oxidative enzymes, especially laccases produced by fungi. In order to reduce production costs, agro-industrial waste can be used in the culture medium composition. Nonionic surfactants, which are only slightly toxic to biological membranes, can be applied, as well as Tween 80, to facilitate the excretion of these enzymes into the culture medium. The objectives of this work were: a) characterize the immersion water of banana straw used in the formulation of the culture medium; b) evaluate laccase production by Pleurotus sajor-caju in culture medium with and without addition of Tween 80, through shaken flasks; c) evaluate the efficiency of the crude enzyme broth in degrading bisphenol-A. The shaken flasks were incubated at 30°C for 12 days. The immersion water had a C:N ratio of 13.8, ash percentage of 28.6%, and pH close to neutrality. The addition of Tween 80 on the culture medium (7.5%, m/v) yielded laccase activity and productivity values equal to 3,016.47 U L-1 and 502.7 U L-1 day-1, respectively. These values were 50 and 33.5 times higher than those obtained in the culture medium without addition of Tween 80 for laccase activity and productivity, respectively. The crude enzyme broth degraded 100% of bisphenol-A after 48 hours, regardless of concentration (500, 750 and 1,000 mg L-1).(AU)


O bisfenol-A é considerado um poluente ambiental capaz de interferir no sistema endócrino dos organismos, ocasionando alterações em seu desenvolvimento e sistema de reprodução. Um método alternativo ao tratamento químico desse tipo de poluente tem sido a utilização de enzimas oxidativas, especialmente as lacases, produzidas por fungos. A fim de diminuir custos de produção, resíduos agroindustriais podem compor o meio de cultivo. Assim, surfactantes não iônicos e pouco tóxicos para as membranas biológicas, como o Tween 80, podem ser utilizados para facilitar a excreção dessas enzimas para o meio de cultivo. Os objetivos deste trabalho foram: caracterizar quimicamente o resíduo água de imersão de palha de bananeira, usado na formulação do meio de cultivo; avaliar a produção de lacase por Pleurotus sajor-caju em meio de cultivo líquido (frascos Erlenmeyer) com e sem adição de Tween 80; e avaliar a eficiência do caldo enzimático bruto em degradar bisfenol-A. Os frascos foram incubados a 30°C, por 12 dias. A água de imersão apresentou relação C:N 13,8, percentual de cinzas 28,6% e pH próximo da neutralidade. O cultivo adicionado de Tween 80 (7,5%, m/v) propiciou valores de atividade e produtividade em lacase iguais a 3.016,47 U L-1 e 502,7 U L-1 dia-1, respectivamente. Esses valores são 50 e 33,5 vezes maiores que os obtidos no cultivo sem adição de Tween 80, para atividade e produtividade em lacase, respectivamente. O caldo enzimático bruto degradou 100% do bisfenol-A após 48 horas, independentemente da concentração (500, 750 e 1.000 mg L-1).(AU)


Subject(s)
Polysorbates , Surface-Active Agents , Pleurotus , Endocrine System , Musa , Laccase , Environmental Pollutants , Enzymes
14.
Article in English | WPRIM | ID: wpr-717354

ABSTRACT

BACKGROUND: Immaturity of the endocrine system that controls the normal menstrual cycle frequently results in abnormal uterine bleeding (AUB) and elicits anemia in adolescent girls. This study was conducted to assess the predictive value of endometrial thickness (ET) for anemia in adolescent girls with AUB. METHODS: A retrospective chart review was performed for a cohort of adolescents (12–18 years old) with AUB who presented over a 10-year period. Complete blood count and ultrasonographic data of 115 adolescent girls with AUB were analyzed. Subjects were classified according to ET as group I (ET < 11 mm) and group II (≥11 mm), and the incidence of anemia was compared. Subjects were also classified according to age as group Y (12–15 years old of age) and group O (16–18 yr), and ET, hemoglobin (Hb), and incidence of anemia were compared. RESULTS: The incidence of anemia in all subjects was 67.8% and was significantly higher in group II than in group I (P < 0.001). The incidence of severe anemia was 56.9% in group II, which was higher than in group I (P=0.039). The incidence of anemia was not significantly different between groups Y and O. However, the incidence of severe anemia was significantly higher in group Y than in group O (P=0.001). CONCLUSION: AUB can result in severe anemia in adolescent girls particularly those who are close to menarche or have a thick endometrium. Early supervision of AUB is required in order to avoid anemia in adolescent girls with AUB.


Subject(s)
Adolescent , Anemia , Blood Cell Count , Cohort Studies , Endocrine System , Endometrium , Female , Humans , Incidence , Menarche , Menstrual Cycle , Organization and Administration , Retrospective Studies , Uterine Hemorrhage
15.
Article in English | WPRIM | ID: wpr-717249

ABSTRACT

Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3′-diindolylmethane (DIM) are phytoestrogens that play chemopreventive roles in the inhibition of carcinogenesis and cancer progression. In this study, the influence of TCS, BPA, Kaem, and DIM on proliferation and apoptotic abilities of VM7Luc4E2 breast cancer cells were examined. MTT assay revealed that TCS (0.1–10 μM), BPA (0.1–10 μM) and E2 (0.01–0.0001 μM) induced significant cell proliferation of VM7Luc4E2 cells, which was restored to the control (0.1% DMSO) by co-treatment with Kaem (30 μM) or DIM (15 μM). Reactive oxygen species (ROS) production assays showed that TCS and BPA inhibited ROS production of VM7Luc4E2 cells similar to E2, but that co-treatment with Kaem or DIM on VM7Luc4E2 cells induced increased ROS production. Based on these results, the effects of TCS, BPA, Kaem, and DIM on protein expression of apoptosis and ROS production-related markers such as Bax and Bcl-xl, as well as endoplasmic reticulum (ER) stress-related markers such as eIF2α and CHOP were investigated by Western blot assay. The results revealed that TCS, and BPA induced anti-apoptosis by reducing ROS production and ER stress. However, Kaem and DIM effectively inhibited TCS and BPA-induced anti-apoptotic processes in VM7Luc4E2 cells. Overall, TCS and BPA were revealed to be distinct xenoestrogens that enhanced proliferation and anti-apoptosis, while Kaem and DIM were identified as natural chemopreventive compounds that effectively inhibited breast cancer cell proliferation and increased anti-apoptosis induced by TCS and BPA.


Subject(s)
Apoptosis , Blotting, Western , Breast Neoplasms , Breast , Carcinogenesis , Cell Proliferation , Endocrine System , Endoplasmic Reticulum , Phytoestrogens , Reactive Oxygen Species , Triclosan
16.
HU rev ; 44(2): 175-181, 2018.
Article in Portuguese | LILACS | ID: biblio-1047960

ABSTRACT

Introdução: A obesidade é um problema de saúde pública mundial. Além das diversas alterações metabólicas encontradas em indivíduos obesos, há evidências de alterações no sistema endócrino, como observado no metabolismo da vitamina D. Objetivo: Avaliar a frequência de deficiência de vitamina D em uma amostra de pacientes adultos com obesidade. Material e métodos: Foi realizado um estudo transversal retrospectivo analisando 183 prontuários dos pacientes atendidos pela primeira vez buscando tratamento para obesidade. Após os fatores de exclusão, restaram 113 prontuários válidos. Resultados: O IMC variou de 30.1 a 77.1, com uma mediana de 44.5 kg/m2. Trinta pacientes (26,55 %) tinham a Vitamina D abaixo de 20 ng/ml, sendo considerados com diagnóstico de Deficiência de Vitamina D. Nenhuma correlação foi encontrada entre os níveis de Vitamina D e os parâmetros antropométricos. Houve associação significativa estatística dos níveis de Vitamina D com colesterol total (r=-0.26; p=0.0053), LDL-colesterol (r=-0.25; p=0.0071), além de uma tendência à significância com os níveis de TGP (r=0.16; p=0.088). Conclusão: Houve uma elevada frequência de deficiência de vitamina D em pacientes obesos. Não houve correlação entre os níveis de vitamina D e os marcadores antropométricos, porém foi encontrada uma correlação inversa de vitamina D com níveis de colesterol total e LDL-colesterol, mostrando a relação com a dislipidemia. Também, houve uma tendência à significância com os níveis de TGP, o que provavelmente remete à esteatose hepática, comum em obesos.


Introduction: Obesity is a global public health problem. In addition to the various metabolic alterations found in obese individuals, there is evidence of alterations in the endocrine system, as observed in vitamin D metabolism. Objective: To evaluate the frequency of vitamin D deficiency in a sample of adult patients with obesity. Material and methods: A retrospective cross-sectional study was carried out analyzing 183 medical charts of who seek treatment for obesity. After exclusion factors, there were 113 valid medical records. Results: The BMI ranged from 30.1 to 77.1, with a median of 44.5 kg / m2. Thirty patients (26.55%) had Vitamin D below 20 ng/ml, being considered as vitamin D deficiency. No correlation was found between vitamin D and anthropometric parameters. There was a statistically significant association of hypovitaminosis D with total cholesterol (r = -0.26, p = 0.0053), LDL cholesterol (r = -0.25, p = 0.0071), and a trend towards significance with TGP levels (r = 0.16; p = 0.088). Conclusion: There was an increased frequency of vitamin D deficiency in obese individuals. There was no correlation between vitamin D levels and anthropometric markers, but an inverse correlation of vitamin D with total and LDL-cholesterol levels was found, showing the relation with dyslipidemia. Also, there was a trend toward significance with TGP levels, which probably refers to hepatic steatosis, common in obese patients.


Subject(s)
Vitamin D , Obesity , Vitamin D Deficiency , Vitamins , Metabolic Syndrome , Endocrine System , Metabolic Diseases , Metabolism
17.
Article in English | WPRIM | ID: wpr-169584

ABSTRACT

The prevalence of obesity around the world has increased sharply. Strong evidence has emerged over the last decades that human exposure to numerous endocrine disrupting chemicals (EDCs) is the cause of obesity and obesity-related metabolic diseases. Many EDCs are manmade chemicals that are released into the environment. EDCs are exogenous compounds that interfere with hormonal regulation and normal endocrine systems, thereby affecting the health of animals and humans. The number of chemicals belonging to EDCs is increasing and some of them are very stable; they persist in the environment (persistent organic pollutants). Although they are banned, their concentrations have been continuously increasing over time. This review gives a brief introduction to common EDCs, and evidence of harmful effects of EDCs on obesity-related diseases; we focus in particular on EDCs' role in causing mitochondrial dysfunction.


Subject(s)
Animals , Endocrine Disruptors , Endocrine System , Humans , Metabolic Diseases , Mitochondria , Obesity , Pediatric Obesity , Prevalence
18.
Journal of Breast Cancer ; : 160-169, 2017.
Article in English | WPRIM | ID: wpr-207533

ABSTRACT

PURPOSE: Estrogen receptor (ER) and progesterone receptor (PR) have been used as indicators of endocrine system status since the mid-1970s in the clinical management of breast cancer. The predictive role of ER in endocrine therapy is undisputed, but the prognostic value of PR is still debated. The aim of this study was to investigate the clinical characteristics and prognosis of ER positive breast cancer with different PR expression levels. METHODS: A population cohort of 3,030 primary invasive ER positive breast cancer patients from a single cancer center underwent surgery and received adjuvant endocrine therapy from 2004 to 2010. The clinical and biological features of these patients with high PR-expressing tumors were compared with those of patients with low PR-expressing tumors. The follow-up data for disease-free survival (DFS), overall survival (OS), and breast cancer specific survival (BCSS) was obtained from 2,778 patients. Cox regression analysis was used to correlate biomarkers and tumor characteristics with DFS, OS, and BCSS. RESULTS: Tumors with low PR expression had more invasive pathological features and biological indexes than those with high PR expression. Low PR expression was an independent poor prognostic factor for DFS (p=0.014; hazard ratio [HR], 0.781; 95% confidence interval [CI], 0.641–0.950), OS (p=0.002; HR, 0.699; 95% CI, 0.560–0.873), and BCSS (p=0.005; HR, 0.714; 95% CI, 0.566–0.902). Furthermore, in low PR expressing tumors, patients who received chemotherapy had better DFS (p=0.002; HR, 0.449; 95% CI, 0.268–0.751), OS (p<0.001; HR, 0.341; 95% CI, 0.192–0.606), and BCSS (p<0.001; HR, 0.292; 95% CI, 0.156–0.549) than patients who did not received chemotherapy. CONCLUSION: Patients with ER positive invasive breast cancer with low PR expressing tumors have a worse prognosis than those with high PR expressing tumors, and these patients can benefit from chemotherapy.


Subject(s)
Asian Continental Ancestry Group , Biomarkers , Breast Neoplasms , Breast , Cohort Studies , Disease-Free Survival , Drug Therapy , Endocrine System , Estrogens , Follow-Up Studies , Humans , Progesterone , Prognosis , Receptors, Progesterone , Tamoxifen
19.
Electron. j. biotechnol ; 19(6): 49-55, Nov. 2016. ilus
Article in English | LILACS | ID: biblio-840313

ABSTRACT

Background: Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) with a weak estrogen-like activity in fish that is found ubiquitously in aquatic environments. However, there has been little study about BPA on the endocrine disrupting effects of crab. In the present study, cDNA of vasa was cloned and characterized in the Charybdis japonica. Histological structures of testis and expression patterns of vasa gene in the testis of C. japonica after treatment with BPA were investigated. Results: The cDNA of vasa is composed of 3051 bp with a 2166 bp open reading frame encoding 721 AA. The deduced amino acid sequence contained eight conserved domains of the DEAD-box protein family. The tissue distribution showed that vasa mRNA was specifically expressed in ovary and testis. Histologically, the sperm cells were decreased in number and an acellular zone was seen in the testis. The transcript level of vasa gradually increased with a significant difference between the experimental and control groups. After BPA exposure with 0.50 and 1.00 mg/L for 1,3, 6 and 9 d, the expression levels of vasa increased. Conclusion: These findings suggest that BPA can increase the expression level of vasa mRNA and influence the development of the testis in C. japonica.


Subject(s)
Animals , Male , Benzhydryl Compounds/pharmacology , Brachyura/drug effects , Brachyura/genetics , DEAD-box RNA Helicases/drug effects , DEAD-box RNA Helicases/genetics , Phenols/pharmacology , Cloning, Molecular , Endocrine System/drug effects , Nucleic Acid Amplification Techniques , Real-Time Polymerase Chain Reaction , Testis/drug effects
20.
Article in English | WPRIM | ID: wpr-59540

ABSTRACT

BACKGROUND: According to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine system, however, there’s no known evidence that urinary 3-PBA have associations with obesity. METHOD: We used data of 3671 participants aged above 19 from the Korean National Environmental Health Survey in 2009–2011. In our analysis, multivariate piece-wise regression and logistic regression analysis were used to investigate the association between urinary 3-PBA (3-Phenoxybenzoic Acid) and BMI. RESULT: Log-transformed level of urinary 3-PBA had significantly positive association with BMI at the low-level range of exposure (p < 0.0001), and opposite associations were observed at the high level exposure (p = 0.04) after adjusting covariates. In piece-wise regression analysis, the flexion point that changes direction of the associations was at around 4 ug/g creatinine of urinary 3-PBA. As quintiles based on concentration of urinary 3-PBA increased to Q4, the ORs for prevalence of overweight (BMI ≥ 23 kg/m2) were increased, and the OR of Q5 was lower than that of Q4 (OR = 1.810 for Q4; OR = 1.483 for Q5). In the analysis using obesity (BMI ≥ 25 kg/m2) as outcome variable, significant associations were observed between obesity and quintiles of 3-PBA, however, there were no differences between the OR of Q5 and that of Q4 (OR = 1.659 for Q4; OR = 1.666 for Q5). CONCLUSION: Our analysis suggested that low-level of pyrethroid exposure has positive association with BMI, however, there is an inverse relationship above the urinary 3-PBA level at 4 ug/g creatinine. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40557-015-0079-7) contains supplementary material, which is available to authorized users.


Subject(s)
Adult , Body Mass Index , Commerce , Creatinine , Endocrine System , Environmental Health , Family Characteristics , Humans , Logistic Models , Methods , Multivariate Analysis , Obesity , Overweight , Prevalence , Pyrethrins
SELECTION OF CITATIONS
SEARCH DETAIL