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1.
Arch. argent. pediatr ; 120(2): e80-e84, abril 2022. ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1363973

ABSTRACT

El síndrome de erupción medicamentosa con eosinofilia y síntomas sistémicos (drug reaction with eosinophilia and systemic symptoms, DRESS), también conocido como síndrome de hipersensibilidad inducida por medicamentos, es una reacción rara potencialmente mortal que causa una erupción grave y que puede provocar insuficiencia multiorgánica. Como con otras erupciones medicamentosas graves, los linfocitos T específicos para un medicamento tienen una función crucial en el síndrome DRESS. El modelo de hapteno/pro-hapteno, el modelo de interacción farmacológica y el modelo alterado de repertorio de péptidos son tres modelos diferentes desarrollados para describir la relación/interacción entre un medicamento o sus metabolitos y el sistema inmunitario. Analizamos nuestra experiencia con el tratamiento con ciclosporina en un caso de síndrome DRESS resistente a esteroides causado por ácido valproico en una niña y sus resultados clínicos, de laboratorio y de antígeno leucocitario humano (HLA).


Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome, is a potentially life-threatening rare reaction that causes a severe rash and can lead to multiorgan failure. As in other severe drug eruptions, drug-specific T lymphocytes play a crucial role in DRESS. The hapten/pro-hapten model, pharmacological interaction model, and altered peptide repertoire model are three different models developed to describe the relationship/interaction between a medication or its metabolites and the immune system. We discuss our experience with cyclosporine treatment in a steroid-resistant DRESS syndrome caused by valproic acid in a girl, as well as her clinical, laboratory, and human leukocyte antigens (HLA) study results


Subject(s)
Humans , Female , Adolescent , Eosinophilia/complications , Eosinophilia/chemically induced , Drug Hypersensitivity Syndrome/diagnosis , Drug Hypersensitivity Syndrome/etiology , Valproic Acid/adverse effects , Cyclosporine , Haptens/adverse effects , HLA Antigens/adverse effects
2.
Braz. j. med. biol. res ; 54(6): e10745, 2021. graf
Article in English | LILACS | ID: biblio-1285666

ABSTRACT

Episodic angioedema with eosinophilia (EAE) is a rare condition characterized by recurrent attacks of angioedema and urticaria accompanied by a marked elevation of peripheral eosinophil count. We report the case of a young female patient diagnosed with EAE associated with urticarial vasculitis. A 40-year-old female patient was admitted to our institution due to recurrent episodes of cheek and eyelid angioedema in the previous year. Episodes of facial angioedema lasted for two months with spontaneous remission afterwards. In addition, she presented pruritic and painful skin eruptions of erythematous circles, which persisted for longer than 24 h, that were palpable, somewhat purplish, and more pronounced on the face, arms, and trunk. Laboratory investigation showed a sustained elevation of white cell counts with marked eosinophilia. Serum IgM, IgE, and IgA were normal; IgG was slightly elevated. C1-esterase inhibitor and tryptase test were normal. Reverse transcriptase-polymerase chain reaction was performed for detection of FIP1L1-PDGFRA and BCR-ABL rearrangements. None of these alterations were found. Skin biopsies were suggestive of urticarial vasculitis. The patient was submitted to esophagogastroduodenoscopy, which showed mild chronic gastritis, with no eosinophilic infiltration. Cardiac dimensions and function were normal. Abdominal ultrasound and total body CT-scan failed to show lymphadenopathy, organomegaly, and tumors. We report the first case of association between episodic angioedema with eosinophilia and urticarial vasculitis. It is possible that both conditions share a physiopathological mechanism, suggesting that it is not just a chance association.


Subject(s)
Humans , Female , Adult , Urticaria/complications , Vasculitis , Eosinophilia/complications , Angioedema/complications , Angioedema/diagnosis , Skin
3.
Rev. cuba. anestesiol. reanim ; 19(3): e639, sept.-dic. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1138883

ABSTRACT

Introducción: Actualmente se buscan biomarcadores que se modifiquen paralelamente con la historia natural de la sepsis. Objetivo: Describir las variaciones de la proteína C reactiva, la eritrosedimentación y el conteo de eosinófilos en pacientes graves portadores de enfermedad infecciosa en diferentes etapas. Método: Se realizó una investigación aplicada y analítica de cohorte, según el estado de la temática, alcance y aplicabilidad de los resultados. Se realizó en pacientes graves con enfermedades infecciosas ingresados en la unidad cuidados intensivos del Hospital Saturnino Lora, durante marzo de 2018 hasta marzo de 2019. El universo estuvo constituido luego de aplicar los criterios de inclusión y exclusión por 41 pacientes, 21 fallecidos y 20 vivos. Las variables estudiadas fueron edad, sexo, origen, gravedad y seguimiento del proceso infeccioso, biomarcadores de respuesta inflamatoria e infección y estado al egreso. Para el procesamiento de la información estadística se emplearon valores promedios como medidas de resumen para variables cuantitativas y porcentajes para variables cualitativas. Para la asociación estadísticamente significativa entre los criterios de interés se aplicó el Test X2 de Independencia. Resultados: La sepsis resultó más frecuente en pacientes masculinos en edades intermedias de la vida, fundamentalmente de origen respiratorio y fue la eosinopenia el biomarcador que más se alteró en los diferentes momentos de la investigación Conclusión: El biomarcador asociado a la sepsis que más se alteró en los diferentes momentos del estudio fue la eosinopenia con mayor asociación como predictor de mortalidad en los diferentes momentos que se realizó el análisis(AU)


Introduction: Currently, biomarkers are being sought that become modified in parallel with the natural history of sepsis. Objective: To describe the variations in C-reactive protein, erythrocyte sedimentation and eosinophil count in severely-ill patients with infectious disease at different stages. Method: An applied and analytical cohort research was carried out, according to the state of the subject, scope and applicability of the outcomes. It was carried out in severely-ill patients with infectious diseases admitted to the intensive care unit of the Saturnino Lora Hospital, from March 2018 to March 2019. The study population was made up after applying the inclusion and exclusion criteria in 41 patients, 21 deceased and 20 alive. The variables studied were age, sex, origin, severity, and monitoring of the infectious process, biomarkers of inflammatory response and infection, and discharge status. For the processing of statistical information, mean values TX 2;were used as summary measures for quantitative variables and percentages for qualitative variables. For the statistically significant association between the criteria of interest, the chi-square Independence test was applied. Results: Sepsis was more frequent among male patients in intermediate ages of life, mainly of respiratory origin; while eosinopenia was the biomarker that was most altered at different moments of the investigation Conclusion: The biomarker associated with sepsis that was most altered at different times of the study was eosinopenia, with the greatest association as a predictor for mortality at the different times when the analysis was performed(AU)


Subject(s)
Humans , Middle Aged , Aged, 80 and over , Biomarkers/analysis , Sepsis/diagnosis , Sepsis/epidemiology , Eosinophilia/complications , Intensive Care Units , Epidemiology, Descriptive , Cohort Studies
5.
Rev. méd. hondur ; 86(1/2): 49-51, ene-. jul. 2018. ilus, tab
Article in Spanish | LILACS | ID: biblio-1007369

ABSTRACT

Introducción: El síndrome de DRESS por sus siglas en inglés (Drug Rash with Eosinophilia and Sistemic Symptoms), re-presenta una enfermedad grave (1) potencialmente letal que incluye reacción cutánea, iebre, anomalías hematológicas e involucro de diversos órganos. Caso Clínico: Masculino de 2 años con antecedente de uso de Fenobarbital, quien ingresó con historia de iebre, adenopatías y rash cutáneo generalizado. En los exámenes de laboratorio se evidencio leucopenia con eosinoilia con elevación de las enzimas hepáticas; se realizaron pruebas de imagen que reportaron hepatomegalia, y nefromegalia bilateral, mostrando evolución satisfactoria inmediata después del retiro de fenobarbital y una terapia esteroidea sistémica. Discusión: Al ser una reacción adversa de baja frecuencia que presenta una mortalidad de hasta un 30% se considera de importancia conocer su comportamiento clínico, así como el diagnóstico y manejo...(AU)


Subject(s)
Humans , Male , Child, Preschool , Phenobarbital/toxicity , Exanthema/complications , Drug Hypersensitivity Syndrome/diagnosis , Eosinophilia/complications , Hypersensitivity
7.
An. bras. dermatol ; 92(4): 534-536, July-Aug. 2017. graf
Article in English | LILACS | ID: biblio-887014

ABSTRACT

Abstract: We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration of vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRb fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH.


Subject(s)
Humans , Female , Child , Eosinophilia/complications , Angioedema/complications , Angioedema/pathology , Recurrence , Immunoglobulin E/blood , Immunoglobulin M/blood , Weight Gain , Interleukins/blood , Eosinophilia/pathology
8.
Braz. j. otorhinolaryngol. (Impr.) ; 83(1): 66-72, Jan.-Feb. 2017. tab, graf
Article in English | LILACS | ID: biblio-839397

ABSTRACT

Abstract Introduction Eosinophilic and noneosinophilic Nasal polyps (NPs) are different subtypes of NPs and require different treatment methods. Objective To compare the histologic characteristics, mRNA and protein expression between Nasal Polyps with and without eosinophilia. Methods NPs tissues were obtained from eighty-six NPs patients during surgery. Eosinophilic and noneosinophilic NPs were distinguished according to immunochemical results of the specimen. The histological, mRNA and protein expression features were compared between the two groups. Results In eosinophilic NPs, we observed a significantly higher GATA-3, IL-5, IL-4, IL-13 mRNA and protein expression. In noneosinophilic NPs, IL-17, IL-23 and RORc mRNA and protein expression were increased. Immunohistochemistry tests showed, more mast cells and less neutrophils in eosinophilic NPs compared with noneosinophilic NPs. Eosinophilic NPs patient presented more severe symptom scores when compared to noneosinophilic NPs. Conclusion We demonstrate for the first time that Th2 is the predominant reaction in eosinophilic NPs while Th17 is the predominant reaction in noneosinophilic NPs. Our study may provide new treatment strategy for NPs.


Resumo Introdução Pólipos nasais (PNs) eosinofílicos e não eosinofílicos são diferentes subtipos de PNs e requerem diferentes métodos de tratamento. Objetivo Comparar as características histológicas e a expressão de mRNAs e proteínas entre PNs com e sem eosinofilia. Método Amostras de PNs foram obtidos de 86 pacientes durante a cirurgia. PNs eosinofílicos e não eosinofílicos foram diferenciados segundo os resultados imunoistoquímicos de cada amostra. As características histológicas e de expressão de mRNAs e de proteínas foram comparadas entre os dois grupos. Resultados Em PNs eosinofílicos, observamos uma expressão significativamente maior dos mRNAs e proteínas GATA-3, IL-5, IL-4 e IL-13. Nos PNs não eosinofílicos, aumentou a expressão dos mRNAs e das proteínas IL-17, IL-23 e RORc. Nos testes imunoistoquímicos, observamos maior número de mastócitos e menor número de neutrófilos nos PNs eosinofílicos, em comparação com PNs não eosinofílicos. Os pacientes com PNs eosinofílicos obtiveram escores de sintomas mais graves vs. PNs não eosinofílicos. Conclusão Demonstramos, pela primeira vez, uma reação Th2 predominante em PNs eosinofílicos e uma reação Th17 predominante em PNs não eosinofílicos. Nosso estudo pode proporcionar novas estratégias terapêuticas para a rinossinusite crônica.


Subject(s)
Humans , Male , Female , Adult , Sinusitis/immunology , Rhinitis/immunology , Nasal Polyps/immunology , Eosinophils/immunology , Sinusitis/complications , Transcription Factors , Severity of Illness Index , RNA, Messenger/metabolism , Immunohistochemistry , Rhinitis/complications , Nasal Polyps/complications , Nasal Polyps/metabolism , Nasal Polyps/pathology , Chronic Disease , Cytokines/immunology , T-Lymphocytes, Helper-Inducer/immunology , Eosinophilia/complications , Eosinophilia/metabolism , Eosinophilia/pathology , Real-Time Polymerase Chain Reaction
9.
An. bras. dermatol ; 91(5): 646-648, Sept.-Oct. 2016. graf
Article in English | LILACS | ID: biblio-827753

ABSTRACT

Abstract: Eosinophilic pustular folliculitis (EPF) or Ofuji disease is a rare dermatosis, prone to recurrence and chronicity. The peak incidence occurs in the third decade of life and its exact etiology remains unknown. Evidence suggests that the expression of adhesion molecules and the production of cytokines activate the follicular unit, but the stimulus that triggers these changes remains unclear. The three clinical variants reported in the literature include classic EPF, immunosuppression-associated EPF, and infancy-associated EPF. We report a case of eosinophilic pustular folliculitis with peculiar epidemiological characteristics, which represents a challenging therapeutic scenario.


Subject(s)
Humans , Female , Adult , Pregnancy Complications , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Indomethacin/therapeutic use , Skin Diseases, Vesiculobullous/drug therapy , Eosinophilia/drug therapy , Folliculitis/drug therapy , Recurrence , Pregnancy , Skin Diseases, Vesiculobullous/complications , Skin Diseases, Vesiculobullous/pathology , Eosinophilia/complications , Eosinophilia/pathology , Folliculitis/complications , Folliculitis/pathology , Granulocytes/pathology
10.
Pesqui. vet. bras ; 36(2): 67-72, fev. 2016. tab, graf
Article in Portuguese | LILACS | ID: lil-777387

ABSTRACT

Ao que tudo indica, o monofluoroacetato de sódio (MF) é o princípio tóxico das numerosas plantas que causam "morte súbita" no Brasil. Eventualmente, observam-se, nos animais intoxicados por MF, grupos de cardiomiócitos com aumento da eosinofilia citoplasmática. Essas alterações cardíacas, no entanto, na maioria dos casos, ainda são incipientes, de difícil interpretação, não há reação inflamatória e devem ser diferenciadas de artefato. O presente trabalho teve como objetivo detectar a presença de alterações regressivas precoces no miocárdio de bovinos e ovinos intoxicados experimentalmente por MF, através da imuno-histoquímica com troponina C (cTnC). Fragmentos de coração de seis bovinos (três que receberam, por via oral, doses únicas de 0,5mg/kg e, os demais, 1,0mg/kg de MF) e cinco ovinos (um recebeu, por via oral, dose única de 0,5mg/kg, outros dois receberam doses de 1,0mg/kg; um ovino recebeu, por via oral, doses subletais repetidas diariamente de 0,1mg/kg/dia, por quatro dias, e outro, 0,2mg/kg/dia por seis dias) foram submetidos à técnica de imuno-histoquímica com anticorpo anti-cTnC. Nos cardiomiócitos dos bovinos e ovinos verificou-se redução dos níveis de expressão da cTnC no citoplasma de grupos de fibras musculares. Diminuição significativa na imunorreatividade ocorreu, sobretudo, em cardiomiócitos que apresentavam, no exame histopatológico, aumento da eosinofilia citoplasmática. A diminuição ou ausência da expressão da cTnC nos animais intoxicados por MF permitiu estabelecer a diferença entre necrose coagulativa de cardiomiócitos e artefato ocasionado pelo fixador. Isso indica que este método pode ser utilizado com segurança para identificação de lesões regressivas precoces, ou não, no miocárdio, independentemente da causa. Adicionalmente, é possível afirmar que, dependendo do tempo de evolução, a toxicose por MF, bem como por plantas causadoras de "morte súbita" em bovinos e ovinos, podem cursar com lesões necrotizantes no miocárdio.


Sodium monofluoroacetate (MF) is the toxic principle of several plants that cause "sudden death" of cattle in Brazil. Groups of cardiomyocites with high cytoplasmic eosinophilia are sometimes observed in animals poisoned by MF. However, this cardiac alteration is difficult to interpret, as there is no inflammatory reaction and it must be differentiated from artifacts. The present study had the objective to detect the presence of early regressive lesions in the myocardium of sheep and cattle experimentally poisoned by MF through immunohistochemistry with troponin C (cTnC). Fragments of the heart muscle from six cattle (three received, orally, single doses of 0.5mg/kg and the others, single doses of 1.0mg/kg) and five sheep (one received, orally, single dose of 0.5mg/kg, the other two received single doses of 1.0mg/kg, one received sublethal daily doses of 0.1mg/kg for four days, and another received daily sublethal doses of 0.2mg/kg for six days) were submitted to immunohistochemistry with antibody anti-cTnC. In the cardiomyocites of cattle and sheep, it was possible to observe reduction of the expression levels for cTnC in the cytoplasm of groups of cardiac muscle fibers. Significant reduction of immunoreactivity ocurred overall in cardiomyocites that presented high cytoplasmic eosinophilia. The decrease or absence of expression for cTnC in animals poisoned by MF allowed to estabilish the difference between coagulative necrosis of cardiomyocites and artifacts caused by fixation. This indicates that this method can be used safely to identify any lesions, early regressive or not, in the myocardium independently of the cause. It is also possible to affirm that poisoning by MF as well as the one caused by "sudden death" causing plants can progress with necrotizing myocardial lesions.


Subject(s)
Animals , Cattle , Eosinophilia/complications , Plant Poisoning/veterinary , Myocytes, Cardiac/pathology , Sheep , Troponin , Immunohistochemistry/veterinary , Death, Sudden/veterinary , Plants, Toxic/poisoning , Heart Injuries/veterinary
11.
An. bras. dermatol ; 90(4): 571-574, July-Aug. 2015. ilus
Article in English | LILACS | ID: lil-759220

ABSTRACT

AbstractEosinophilic cellulitis or Wells syndrome is an uncommon skin condition of unknown etiology that can occur alone or associated with other conditions. Typically, it presents with recurrent pruritic, erythematous and edematous plaques, but it can also show clinical polymorphism. Besides the cutaneous lesions, patients can experience systemic manifestations like fever, malaise, arthralgia and peripheral blood eosinophilia. We describe a case of this rare syndrome that presented with polymorphic cutaneous lesions associated with a serious systemic disease, which was revealed through the investigation of the cutaneous disease.


Subject(s)
Aged , Female , Humans , Cellulitis/complications , Eosinophilia/complications , Leukemia, Lymphocytic, Chronic, B-Cell/complications , Biopsy , Cellulitis/pathology , Diagnosis, Differential , Eosinophilia/pathology , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Skin/pathology
13.
Rev. méd. Chile ; 143(5): 577-583, ilus, tab
Article in Spanish | LILACS | ID: lil-751702

ABSTRACT

Background: DRESS Syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is an uncommon disease caused by drugs. It is characterized by a polymorphic disseminated eruption with fever and multiple organ dysfunction. Aim: To report the etiology, characteristics, treatment, prognosis, and follow up of patients with DRESS Syndrome admitted to a clinical hospital. Material and Methods: Review of medical records of patients admitted for drug reactions, selecting those patients complying with clinical criteria for DRESS Syndrome. Drugs used during three months prior to the onset of symptoms were evaluated as possible causes of the disease. Results: Nine patients aged 16 to 68 years (six males) complied with the clinical criteria for the disease. The causative medications were carbamazepine in three patients, phenytoin in three, antituberculous drugs in two and amoxicillin in one. All were treated with systemic steroids with a complete clinical resolution. Conclusions: DRESS syndrome is usually underdiagnosed and has a good response to systemic steroids.


Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Young Adult , Dexamethasone/therapeutic use , Drug Hypersensitivity Syndrome/drug therapy , Prednisone/therapeutic use , Carbamazepine/adverse effects , Drug Hypersensitivity Syndrome/etiology , Eosinophilia/complications , Exanthema/complications , Phenytoin/adverse effects , Retrospective Studies
14.
Int. j. odontostomatol. (Print) ; 9(1): 91-95, Apr. 2015. ilus
Article in English | LILACS | ID: lil-747483

ABSTRACT

Tumor related tissue eosinophilia (TATE) is a known phenomenon but its role in prognostics and correlation with size of the primary tumor is still controversial. Using a stain, like Carbol chromotrope, that targets eosinophils exclusively and vividly, offers an advantage over haematoxylin and eosin, which was used in most of the studies. Forty-nine cases of oral squamous cell carcinoma, where the TNM staging has been recorded in their history, was taken and stained with Lendrum's carbol chromotrope. Significant difference in the eosinophil count with varying size of the tumor and a parallel increase in the number noted, with increase in size. There is a corresponding increase in the number of eosinophils infiltrating the tumor with increase in size of oral squamous cell carcinoma.


La eosinofilia tisular asociada a tumores (TATE) es un fenómeno conocido, sin embargo su pronóstico y correlación con el tamaño del tumor primario aún es tema de controversia. El uso de cromotropo como tinción dirigida exclusivamente a los eosinófilos, ofrece una ventaja sobre la hematoxilina-eosina, que ha sido utilizada en la mayoría de los estudios. Se estudiaron células escamosas en 49 casos de carcinoma oral, con registro del estadio TNM. Las células fueron teñidas con carbol cromotropo de Lendrum. Se observó una diferencia significativa en el recuento de eosinófilos con el tamaño del tumor y un aumento paralelo en número, con el aumento de tamaño. Hay un aumento correspondiente en el número de eosinófilos que infiltran el tumor con aumento en el tamaño de carcinoma de células escamosas orales.


Subject(s)
Humans , Mouth Neoplasms/complications , Carcinoma, Squamous Cell/complications , Eosinophilia/complications , Eosinophils/metabolism , Squamous Cell Carcinoma of Head and Neck/complications , Prognosis , Cell Differentiation , Analysis of Variance , Color Therapy , Coloring Agents , Eosinophils/pathology , Tumor Microenvironment , Neoplasm Invasiveness
15.
Article in English | WPRIM | ID: wpr-51153

ABSTRACT

We report here a case of strongyloidiasis in a 72-year-old diabetic patient (woman) accompanied by gastrointestinal stromal tumor receiving imatinib therapy, first diagnosed as hypereosinophilic syndrome and treated with steroids for uncontrolled eosinophilia. She suffered from lower back pain and intermittent abdominal discomfort with nausea and diagnosed with gastrointestinal stromal tumor. After post-operative imatinib treatment eosinophilia persisted, so that steroid therapy was started under an impression of hypereosinophilic syndrome. In spite of 6 months steroid therapy, eosinophilia persisted. Stool examination was performed to rule out intestinal helminth infections. Rhabditoid larvae of Strongyloides stercoralis were detected and the patient was diagnosed as strongyloidiasis. This diagnosis was confirmed again by PCR. The patient was treated with albendazole for 14 days and her abdominal pain and diarrhea improved. This case highlights the need for thorough investigation, including molecular approaches, to test for strongyloidiasis before and during steroid therapies.


Subject(s)
Aged , Albendazole/administration & dosage , Animals , Diabetes Mellitus, Type 2/complications , Eosinophilia/complications , Female , Gastrointestinal Stromal Tumors/complications , Humans , Imatinib Mesylate/administration & dosage , Steroids/administration & dosage , Strongyloides stercoralis/genetics , Strongyloidiasis/drug therapy
16.
Article in English | IMSEAR | ID: sea-157663

ABSTRACT

Eosinophilic gastroenteritis is a rare disease of unknown etiology characterized by eosinophilic infiltration of bowel wall to a variable depth. A 38 year old female presented with loose stool and vomiting since 3 days. She gave history of pain abdomen and weight loss since six months. Barium study revealed ascending colon stricture just proximal to the hepatic flexure ? malignant. A colonic biopsy was done, which was reported as edematous colonic mucosa with mild increase in eosinophils. Intra-operatively, a dense long segment stricture was found in the ascending colon extending to the caecum which warranted a right hemicolectomy. Histopathology revealed dense infiltration of eosinophils in the entire thickness of ileal and caecal wall. The diagnosis of eosinophilic gastroenteritis was made. Patient responded well to steroids. The case is being reported to highlight its rarity due to caecal involvement, presentation as intestinal obstruction and missed diagnosis on endoscopic biopsy.


Subject(s)
Adult , Enteritis/complications , Enteritis/drug therapy , Eosinophilia/complications , Female , Gastritis/complications , Gastritis/drug therapy , Humans , Intestinal Obstruction/drug therapy , Intestinal Obstruction/epidemiology , Intestinal Obstruction/etiology , Intestine, Small/drug therapy
17.
Gut and Liver ; : 224-227, 2014.
Article in English | WPRIM | ID: wpr-187166

ABSTRACT

Eosinophilic gastroenteritis (EGE) is a rare disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, especially the stomach and duodenum. EGE has vague, nonspecific symptoms, including nausea, vomiting, abdominal pain, diarrhea, weight loss, ascites, and malabsorption. Here, we report a patient with EGE presenting with concurrent acute pancreatitis and ascites. A 68-year-old woman was admitted with abdominal pain, nausea, vomiting, and watery diarrhea. Laboratory findings revealed elevated serum titers of amylase, lipase, and peripheral blood eosinophil count. An abdominopelvic computed tomography scan showed a normal pancreas, moderate amount of ascites, and duodenal thickening. A esophagogastroduodenoscopy showed patchy erythematous mucosal lesions in the 2nd portion of the duodenum. Biopsies from the duodenum indicated eosinophilic infiltration in the lamina propria. The patient was successfully treated with prednisolone and montelukast. Despite its unusual occurrence, EGE may be considered in the differential diagnosis of unexplained acute pancreatitis, especially in a patient with duodenal edema on imaging or peripheral eosinophilia.


Subject(s)
Acute Disease , Aged , Ascites/etiology , Enteritis/complications , Eosinophilia/complications , Female , Gastritis/complications , Humans , Pancreatitis/etiology , Tomography, X-Ray Computed
18.
Rev. gastroenterol. Perú ; 33(1): 39-42, ene.-mar. 2013. ilus, tab
Article in Spanish | LIPECS, LILACS, LIPECS | ID: lil-692419

ABSTRACT

Objetivos: 1) Determinar la prevalencia de incremento de eosinófilos en mucosa colónica en pacientes con colitis linfocítica (CL). 2) Determinar la coexistencia de colitis eosinofílica (CE) en pacientes con CL. Materiales y métodos: Las biopsias colónicas de pacientes adultos con diarrea crónica diagnosticados como CL en el hospital Daniel A. Carrión durante octubre 2009 a marzo 2012 fueron revisadas de forma independiente por 2 patólogos. Microscópicamente, se investigó y cuantificó la presencia de eosinófilos en mucosa colónica. Resultados: Se incluyeron 68 casos de CL, de los cuales 76,5% tuvieron eosinófilos elevados en la mucosa colónica y en 51,4% se pudo hacer el diagnóstico de CE según los criterios establecidos. Conclusión: Tres de cuatro pacientes con CL presentan eosinófilos elevados y 1 de cada 2 pacientes con CL cumple criterios para CE.


Objectives: 1) To determine the prevalence of increased number of eosinophils in colonic mucosa of patients with lymphocytic colitis (LC). 2) To determine the coexistence of eosinophilic colitis (EC) in patients with lymphocytic colitis. Materials and methods: slides of adult patients with cronic diarrhea with diagnosis of LC were reviewed between October 2009 and March 2012. The number of eosinophils was quantified. Results: Sixty eight patients with LC were included. Elevated eosinophils were found in 76.5 and in 51.4% a diagnosis of EC was established. Conclusion: 3 out of 4 patients with LC had elevated eosinophils and 1 of 2 patients with LC had criteria for EC.


Subject(s)
Female , Humans , Male , Middle Aged , Colitis, Lymphocytic/complications , Diarrhea/complications , Eosinophilia/complications , Eosinophilia/pathology , Chronic Disease , Colitis, Lymphocytic/pathology , Colitis/complications , Colitis/pathology , Eosinophils , Leukocyte Count
19.
Article in English | WPRIM | ID: wpr-197165

ABSTRACT

Eosinophilic meningitis, caused by the nematode Angiostrongylus cantonensis, is prevalent in northeastern Thailand, most commonly in adults. Data regarding clinical manifestations of this condition in children is limited and may be different those in adults. A chart review was done on 19 eosinophilic meningitis patients aged less than 15 years in Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand. Clinical manifestations and outcomes were reported using descriptive statistics. All patients had presented with severe headache. Most patients were males, had fever, nausea or vomiting, stiffness of the neck, and a history of snail ingestion. Six patients had papilledema or cranial nerve palsies. It was shown that the clinical manifestations of eosinophilic meningitis due to A. cantonensis in children are different from those in adult patients. Fever, nausea, vomiting, hepatomegaly, neck stiffness, and cranial nerve palsies were all more common in children than in adults.


Subject(s)
Adolescent , Adult , Aged , Angiostrongylus cantonensis/isolation & purification , Animals , Child , Child, Preschool , Eosinophilia/complications , Female , Humans , Male , Meningitis/complications , Middle Aged , Patient Outcome Assessment , Strongylida Infections/parasitology , Thailand , Young Adult
20.
Salud(i)ciencia (Impresa) ; 19(3): 278-280, ago. 2012.
Article in Spanish | LILACS | ID: lil-686335

ABSTRACT

La miocardiopatía dilatada aguda con insuficiencia cardíaca parece constituir una forma de presentación del compromiso miocárdico por eosinofilia periférica incluso en pacientes de avanzada edad


Subject(s)
Humans , Female , Aged , Cardiomyopathy, Dilated/complications , Cardiomyopathy, Dilated/diagnosis , Cardiomyopathy, Dilated/therapy , Eosinophilia/complications , Eosinophilia/diagnosis
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