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China Journal of Chinese Materia Medica ; (24): 4566-4572, 2019.
Article in Chinese | WPRIM | ID: wpr-1008230


Nowadays,the advantages of traditional Chinese medicine(TCM) for treatment of tumors are increasingly prominent.Triptolide shows wide-spectrum and highly effective anti-tumor activity. Moreover,nano-carrier-based triptolide drug delivery system is more powerful in improving water solubility and pharmacokinetic behavior of the drug,but it is easy to cause toxic and side effects that should not be neglected on human body. Because of tumor vascular heterogeneity and PEGylation dilemma,nanoparticulate drug delivery systems need to overcome multiple physiological and pathological barriers from drug administration to functioning. It is difficult for traditional triptolide nanoparticulate drug delivery systems to achieve active accumulation of nano-drug in tumor tissues and specific drug release in tumor target site solely relying on enhanced permeability and retention effect of solid tumor,limiting their application and clinical transformation in treatment of tumors. Based on the traditional nano-preparation system,the new functionalized nano-drug delivery system further enhances the nano-drug enrichment,penetration and controlled release at the tumor sites,which is of great significance in improving bioavailability,anti-tumor efficacy and reducing the side effects of drugs. In this paper,we summarized and analyzed the researches on new triptolide functionalized nano-drug delivery system from four perspectives,including tumor active targeting,tumor microenvironment response,polymer-drug conjugates,and multidrug co-delivery for tumor treatment,expecting to provide ideas for in-depth research and clinical application of triptolide and some other active anti-tumor TCM ingredients.

Humans , Diterpenes/chemistry , Drug Delivery Systems , Epoxy Compounds/chemistry , Nanoparticles , Phenanthrenes/chemistry
Rev. méd. Chile ; 143(1): 14-21, ene. 2015. ilus, tab
Article in Spanish | LILACS | ID: lil-742546


Background: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported. Aim: To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material and Methods: Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction. Results: Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI): 1.4-16), 1.59 (95% CI: 1.28-1.98) and 11.02 (95% CI: 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day. Conclusions: Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.

Animals , Female , Humans , Mice , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/drug therapy , Diterpenes/administration & dosage , Epoxy Compounds/administration & dosage , Paclitaxel/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/chemistry , Apoptosis/drug effects , Breast Neoplasms/genetics , Breast Neoplasms/metabolism , Breast Neoplasms/pathology , Cell Line, Tumor , Diterpenes/chemistry , Drug Synergism , Epoxy Compounds/chemistry , Lactones/administration & dosage , Lactones/chemistry , Mice, Nude , Oxidative Stress/drug effects , Poly(ADP-ribose) Polymerases/genetics , Poly(ADP-ribose) Polymerases/metabolism , Reactive Oxygen Species/metabolism , Structure-Activity Relationship , Transcriptional Activation/drug effects , Tumor Burden , Xenograft Model Antitumor Assays
Hist. ciênc. saúde-Manguinhos ; 21(4): 1093-1112, Oct-Dec/2014.
Article in Portuguese | LILACS | ID: lil-732505


O objetivo deste trabalho é analisar o discurso do excesso sexual produzido pelo pensamento social brasileiro das décadas de 1920 e 1930 na sua interlocução com o discurso médico da época. De inspiração foucaultiana, o texto inscreve-se no campo da história dos saberes e está subsidiado por documentos sociológicos e médicos do período de referência. No quadro da recodificação vintecentista sobre o imaginário da brasilidade, o tema do excesso sexual foi revisitado pelo pensamento sociológico local, forjando-o ora como um perturbador do projeto civilizatório nacional, ora como um traço que deveria ser positivado por ter sido a condição de possibilidade da hibridização cultural de suas matrizes identitárias.

The objective of this article is to analyze the discourse of sexual excess produced by Brazilian social thinking in the 1920s and 1930s and its dialog with the medical discourse at the time. Inspired by Foucault, it is within the field of the history of knowledge and is supported by sociology and medical documents from the period in question.Within the framework of the twentieth century re-codification of the imagery of Brazilianness, the topic of sexual excess was revisited by local thinkers in the field of sociology and seen either as disturbing the national civilizing project, or as a trait that should be seen in a positive light because it permitted the cultural hybridization of its sources of identity.

Animals , Cattle , Adenine/metabolism , DNA Adducts/metabolism , Epoxy Compounds/metabolism , Guanine/metabolism , Mutagens/metabolism , DNA Adducts/chemistry , DNA Adducts/isolation & purification , Epoxy Compounds/chemistry , Epoxy Compounds/isolation & purification , Guanosine/metabolism , Mutagens/chemistry , Mutagens/isolation & purification
Rev. panam. salud pública ; 36(5): 290-299, nov. 2014. tab
Article in English | LILACS | ID: lil-733231


OBJECTIVE: To examine the prevalence of blindness, visual impairment, and related eye diseases and conditions among adults in El Salvador, and to explore socioeconomic inequalities in their prevalence by education level and occupational status, stratified by sex. METHODS: Based upon the Rapid Assessment of Avoidable Blindness (RAAB) methodology, this nationwide sample comprised 3 800 participants (3 399 examined) ≥ 50 years old from 76 randomly selected clusters of 50 persons each. The prevalence of blindness, visual impairment and related eye diseases and conditions, including uncorrected refractive error (URE), was calculated for categories of education level and occupational status. Multiple logistic regression models were fitted to calculate odds ratios (ORs) and 95% confidence intervals (CIs) and stratified by sex. RESULTS: Age-adjusted prevalence was 2.4% (95% CI: 2.2-2.6) for blindness (men: 2.8% (95% CI: 2.5-3.1); women: 2.2% (95% CI: 1.9-2.5)) and 11.8% (95% CI: 11.6-12.0) for moderate visual impairment (men: 10.8% (95% CI: 10.5-11.1); women: 12.6% (95% CI: 12.4-12.8)). The proportion of visual impairment due to cataract was 43.8% in men and 33.5% in women. Inverse gradients of socioeconomic inequalities were observed in the prevalence of visual impairment. For example, the age-adjusted OR (AOR) was 3.4 (95% CI: 2.0-6.4) for visual impairment and 4.3 (95% CI: 2.1-10.4) for related URE in illiterate women compared to those with secondary education, and 1.9 (95% CI: 1.1-3.1) in cataract in unemployed men. CONCLUSIONS: Blindness and visual impairment prevalence is high in the El Salvador adult population. The main associated conditions are cataract and URE, two treatable conditions. As socioeconomic and gender inequalities in ocular health may herald discrimination and important barriers to accessing affordable, good-quality, and timely health care services, prioritization of public eye health care and disability policies should be put in place, particularly among women, the unemployed, and uneducated people.

OBJETIVO: Analizar la prevalencia de la ceguera, la deficiencia visual, y las enfermedades y afecciones oculares relacionadas en adultos de El Salvador, y explorar las desigualdades socioeconómicas en cuanto a su prevalencia según el nivel educativo y la situación laboral, estratificados por sexos. MÉTODOS: Se adoptó el método de Evaluación Rápida de la Ceguera Evitable, y se escogió una muestra a escala nacional de 3 800 participantes (de ellos se examinaron 3 399) de 50 años de edad o mayores, pertenecientes a 76 agrupamientos seleccionados aleatoriamente y constituidos por 50 personas cada uno. Se calculó la prevalencia de la ceguera, la deficiencia visual y las enfermedades y afecciones oculares relacionadas, incluido el error de refracción no corregido, según las diferentes categorías de nivel educativo y situación laboral. Se emplearon modelos de regresión logística múltiple para calcular las razones de posibilidades (OR) y los intervalos de confianza (IC) de 95%, y se estratificaron por sexos. RESULTADOS: La prevalencia ajustada por edad fue de 2,4% (IC de 95%: 2,2-2,6) para la ceguera (hombres: 2,8% [IC de 95%: 2,5-3,1]; mujeres: 2,2% [IC de 95%: 1,9-2,5]) y de 11,8% (IC de 95%: 11,6-12,0) para la deficiencia visual moderada (hombres: 10,8% [IC de 95%: 10,5-11,1]; mujeres: 12,6% [IC de 95%: 12,4-12,8]). La proporción de deficiencias visuales debidas a catarata fue de 43,8% en los hombres y de 33,5% en las mujeres. En la prevalencia de la deficiencia visual se observaron gradientes inversos de desigualdades socioeconómicas. Por ejemplo, la OR ajustada por edad fue de 3,4 (IC de 95%: 2,0-6,4) para la deficiencia visual y de 4,3 (IC de 95%: 2,1-10,4) para el error de refracción no corregido relacionado en las mujeres analfabetas, en comparación con las que tenían un nivel de educación secundaria, y fue de 1,9 (IC de 95%: 1,1-3,1) para la catarata en los hombres desempleados. CONCLUSIONES: La prevalencia de ceguera y deficiencia visual es alta en la población adulta de El Salvador. Las principales afecciones asociadas son la catarata y el error de refracción no corregido, ambas tratables. Puesto que las desigualdades socioeconómicas y de género en materia de salud ocular pueden ser indicativas de discriminación y de la existencia de barreras importantes para obtener acceso a servicios de atención de salud asequibles, de buena calidad y oportunos, es preciso dar prioridad a la atención oftalmológica pública y a las políticas dirigidas a corregir la discapacidad, en particular en las mujeres y en las personas desempleadas y sin formación.

Carcinogens/chemistry , Carcinogens/chemical synthesis , DNA Adducts/biosynthesis , DNA Adducts/chemistry , Epoxy Compounds/chemistry , Epoxy Compounds/chemical synthesis , Guanosine/chemistry , DNA Adducts/drug effects , Drug Stability , Epoxy Compounds/toxicity , Kinetics , Mass Spectrometry , Stereoisomerism
Rev. panam. salud pública ; 36(5): 324-330, nov. 2014. ilus, tab
Article in Portuguese | LILACS | ID: lil-733235


OBJETIVO: Revisar as experiências de atenção fisioterapêutica dirigidas à população pediátrica descritas na literatura e analisar a produção de conhecimento sobre fisioterapia no contexto da atenção primária à saúde infantil (APSI). MÉTODOS: Foi realizada uma revisão sistemática conforme PRISMA, com busca nas seguintes bases de dados: MEDLINE, LILACS, SciELO, PubMed, Scopus, Cochrane; banco de teses da CAPES; e System for Information on Grey Literature in Europe (SIGLE). Foram utilizados os descritores "atenção primária à saúde", "fisioterapia", "lactente ou criança" e seus correspondentes na língua inglesa e espanhola, sem restrição de ano de publicação. RESULTADOS: Analisamos 13 artigos de seis países, reunidos em três eixos temáticos: dilemas profissionais (três artigos), competências e habilidades específicas para a APSI (sete artigos) e relatos de prática (quatro artigos). Os dilemas profissionais mencionados foram a ampliação do papel do fisioterapeuta para incluir ambientes comunitários, compartilhando a tomada de decisão com as famílias, e o trabalho em colaboração com outros serviços de saúde para identificar as necessidades da criança. As competências e habilidades citadas foram a identificação de sintomas clínicos e socioculturais para além das condições musculoesqueléticas, o diagnóstico fisioterapêutico precoce, a prevenção contra o uso excessivo de medicamentos e a capacidade de trabalhar em equipe. Os relatos de prática discorreram sobre estimulação em crianças com quadros neurológicos, tratamento respiratório e grupos com mães de crianças com esses acometimentos. CONCLUSÕES: O baixo número de estudos sugere desconhecimento quanto ao modo como a fisioterapia se insere na APSI e, provavelmente, quanto às habilidades profissionais necessárias nesse ambiente. Assim, são necessários mais estudos para fornecer dados sobre a área e um esforço de qualificação continuada por parte dos fisioterapeutas.

OBJECTIVE: To review pediatric physical therapy experiences described in the literature and to analyze the production of knowledge on physical therapy in the context of pediatric primary health care (PPHC). METHODS: A systematic review was conducted according to the PRISMA criteria. The following databases were searched: MEDLINE, LILACS, SciELO, PubMed, Scopus and Cochrane; Brazilian Ministry of Health's CAPES doctoral dissertations database; and System for Information on Grey Literature in Europe (SIGLE). The following search terms were used: ["primary health care" and ("physical therapy" or "physiotherapy") and ("child" or "infant")] and equivalent terms in Portuguese and Spanish, with no restriction on publication year. RESULTS: Thirteen articles from six countries were analyzed and grouped into three main themes: professional dilemmas (three articles), specific competencies and skills required in a PPHC setting (seven articles), and practice reports (four articles). Professional dilemmas involved expanding the role of physical therapists to encompass community environments and sharing the decision-making process with the family, as well as collaborative work with other health services to identify the needs of children. The competencies and skills mentioned in the literature related to the identification of clinical and sociocultural symptoms that go beyond musculoskeletal conditions, the establishment of early physical therapy diagnoses, prevention of overmedication, and the ability to work as team players. Practice reports addressed stimulation in children with neurological diseases, respiratory treatment, and establishing groups with mothers of children with these conditions. CONCLUSIONS: The small number of studies identified in this review suggests that there is little knowledge regarding the roles of physical therapists in PPHC and possibly regarding the professional abilities required in this setting. Therefore, further studies are required to provide data on the field, along with a continuing education effort on the part of physical therapists.

Adenosine/analogs & derivatives , Epoxy Compounds/chemistry , Inosine/chemistry , Mutagens/chemistry , Adenosine/chemistry , Chromatography, High Pressure Liquid , DNA Adducts/chemistry , Inosine/analogs & derivatives , Kinetics , Magnetic Resonance Spectroscopy , Spectrometry, Mass, Fast Atom Bombardment , Spectrophotometry, Ultraviolet
Braz. oral res ; 27(2): 176-182, Mar-Apr/2013. tab, graf
Article in English | LILACS | ID: lil-667995


It has been suggested that the epoxy paint used to coat metal substrates in industrial electrostatic painting applications could also be used to mask metal clasps in removable dental prostheses (RDP). The purpose of this study was to evaluate both the influence of thermal cycling and the in vitro roughness of a surface after application of epoxy paint, as well as to assess the micromorphology of a cobalt-chromium (CoCr) based metal structure. Sixty test specimens were fabricated from a CoCr alloy. The specimens were separated into three groups (n = 20) according to surface treatment: Group 1 (Pol) - polished with abrasive stone and rubbers; Group 2 (Pol+Epo) - polished and coated with epoxy paint; Group 3 (Epo) - air-abraded with aluminum oxide particles and coated with epoxy paint. The surface roughness was evaluated before and after 1000 thermal cycles (5°C and 50°C). The surface micromorphology was verified by scanning electron microscopy (SEM). The two-way repeated measures ANOVA showed significant differences among surface treatments (p < 0.0001), but no difference was found before and after thermal cycling (p = 0.6638). The CoCr-based metal alloy surfaces treated with epoxy paint (Groups 2 and 3) were rougher than the surfaces that were only polished (Group 1). Thermal cycling did not influence surface roughness, or lead to chipping or detachment of the epoxy paint.

Humans , Chromium Alloys/chemistry , Epoxy Compounds/chemistry , Paint , Prosthesis Coloring/methods , Analysis of Variance , Dental Clasps , Hot Temperature , Materials Testing , Microscopy, Electron, Scanning , Surface Properties , Time Factors
Egyptian Journal of Chemistry. 1995; 38 (3): 349-54
in English | IMEMR | ID: emr-107735
Rev. cuba. farm ; 27(2): 81-7, jul.-dic. 1993. ilus
Article in Spanish | LILACS | ID: lil-149860


Se describe la síntesis de 5alfa-androst-9alfa-epoxi-3beta, 17beta-dioles 12beta-dioles 12beta-funcionalizados (H,OH,OAc) por reducción (NaBH4) y epoxidación (m-CIPBA) de las 5alfa-androst-9(11(-en-3beta-ol-17-onas correspondientes. Se estudia la reacción de apertura de estos epóxidos con HClO4 70 por ciento en metanol y se corrobora, la importancia del grupo 12beta-OAc en la misma

Androstanes/chemical synthesis , Epoxy Compounds/chemistry , Sapogenins/chemistry
Bauru; s.n; 1984. 150 p. ilus, tab, graf.
Thesis in Portuguese | LILACS, BBO | ID: lil-229946


Uma sucessäo de experimentos foi realizada para verificar a causa do enegrecimento do AH26, mormente quando recebia 20 por cento de hidróxido de cálcio no pó. Uma interaçäo entre o bisfenol A, a hexametilenotetramina e o óxido de bismuto foi encontrada. A mesma também se dava substituindo-se este último pelo subnitrato ou carbonato de bismuto. Este redundou num discreto acinzentamento. Testes de alteraçöes de cor, textura e volume, de radiopacidade, de consistência e tempo de presa prosseguiram sucessivamente buscando outros radiopacificadores e resinas tipo bisfenol A e respectivos endurecedores, para obtençäo de novos cimentos epóxicos viáveis para obturaçöes de canais radiculares. Após 30 experimentos chegou-se a quatro formulaçöes...

Dental Cements/chemistry , Root Canal Obturation/adverse effects , Zinc Oxide-Eugenol Cement/chemistry , Epoxy Compounds/chemistry , Gutta-Percha/chemistry , Calcium Hydroxide/chemistry , Dental Materials/chemistry