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1.
Asian Journal of Andrology ; (6): 171-175, 2022.
Article in English | WPRIM | ID: wpr-928501

ABSTRACT

Mesenchymal stem cells (MSCs) secrete various cytokines with angiogenic and neuroprotective effects. This study aimed to assess the effects of human umbilical cord Wharton's jelly-derived MSCs (hWJ-MSCs) on diabetes-related intracavernosal pressure (ICP) impairment in rats. hWJ-MSCs were isolated from human umbilical cord Wharton's jelly and transplanted into the corpus cavernosum of streptozotocin (STZ)-induced diabetic rats by unilateral injection. The erectile function was evaluated at 4 weeks, as well as the expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), endothelial nitric oxide synthase (eNOS), and insulin-like growth factor 1 (IGF1). STZ-induced diabetic rats showed impaired ICP, which was significantly improved by hWJ-MSC treatment. VEGF, eNOS, IGF1, and bFGF expression levels were higher in hWJ-MSC injection sites than those in control ones in STZ-induced diabetic rats. These results suggest that hWJ-MSC transplantation might improve diabetic erectile dysfunction through increased production of paracrine growth factors, highlighting a novel potential therapeutic option for erectile dysfunction.


Subject(s)
Animals , Cell Differentiation , Diabetes Mellitus, Experimental/therapy , Erectile Dysfunction/therapy , Humans , Male , Mesenchymal Stem Cell Transplantation/methods , Rats , Umbilical Cord , Vascular Endothelial Growth Factor A , Wharton Jelly
2.
Article in Chinese | WPRIM | ID: wpr-927362

ABSTRACT

Data mining technology was adopted to analyze the rules of acupoint selection in treatment of erectile dysfunction with acupuncture and moxibustion. All of the articles for acupuncture and moxibustion in treatment of erectile dysfunction were searched from the databases, i.e. Chinese national knowledge infrastructure (CNKI), Wanfang database, VIP, Chinese biomedical literature database (SinoMed) and PubMed, and the clinical trials on erectile dysfunction treated with acupuncture and moxibustion were screened. The database was set up by using Excel 2019 and input into R 4.0.3, and then, the therapeutic method, use frequency of acupoint, meridian tropism, collection visualization analysis, cluster analysis and association rule analysis were summarized. A total of 240 articles were included, with 516 prescriptions and 145 acupoints involved. The methods for treatment of erectile dysfunction included acupuncture and moxibustion therapy, acupuncture, acupoint injection, electroacupuncture, etc. The acupoints with high use frequency were Guanyuan (CV 4), Shenshu (BL 23), Sanyinjiao (SP 6), Mingmen (GV 4), Zusanli (ST 36), Zhongji (CV 3), Ciliao (BL 32), Qihai (CV 6), Taixi (KI 3) and Taichong (LR 3). The meridians involved with high frequency were the bladder meridian of foot-taiyang, the conception vessel, the spleen meridian of foot-taiyin, etc. The common acupoint combination was Shangliao (BL 31), Zhongliao (BL 33), Ciliao (BL 32), Xialiao (BL 34) and Sanyinjiao (SP 6), Shenshu (BL 23), Guanyuan (CV 4). In association rule analysis (confidence ≥ 90%, support ≥ 20%), there were 27 association rules in total. The acupoint combination with the highest support referred to "Shenshu (BL 23), Sanyinjiao (SP 6)→Guanyuan (CV 4)" (support 46.7%) and the acupoint combination with the highest confidence was "Sanyinjiao (SP 6), Qihai (CV 6)→Guanyuan (CV 4)" (confidence 98.0%). The acupoints could be divided into 5 effective clusters. Acupuncture and moxibustion therapy has a certain of rules of acupoint selection in treatment of erectile dysfunction, which provides the evidences for modern clinical trial and treatment.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Data Mining , Erectile Dysfunction/therapy , Humans , Male , Meridians , Moxibustion , Technology
4.
Chinese Acupuncture & Moxibustion ; (12): 1325-1330, 2021.
Article in Chinese | WPRIM | ID: wpr-921054

ABSTRACT

OBJECTIVE@#To observe the clinical therapeutic effect on functional erectile dysfunction (FED) of kidney deficiency and liver stagnation treated by @*METHODS@#A total of 120 patients with FED were randomized into an observation group (60 cases, 2 cases dropped off) and a control group (60 cases, 4 cases dropped off). In the control group, the patients were treated with oral @*RESULTS@#After treatment, the scores of IIEF5, EHS and EDITS were all increased as compared with the values before treatment (@*CONCLUSION@#The combined therapy of


Subject(s)
Drugs, Chinese Herbal/therapeutic use , Erectile Dysfunction/therapy , Humans , Male , Moxibustion , Vascular Endothelial Growth Factor A
5.
Int. braz. j. urol ; 46(6): 934-942, Nov.-Dec. 2020. tab, graf
Article in English | LILACS | ID: biblio-1134254

ABSTRACT

ABSTRACT To evaluate the efficiency of an energy density of 0.05mj/mm2 of low intensity extracorporeal shockwave therapy (Li-ESWT) on erectile dysfunction (ED) patients.A total of 45 ED patients met the inclusion criteria, including 7 PDE5i responders and 38 nonresponders. All the patients have already been delivered 10000 shockwaves of total seven treatment points twice a week for 4 weeks. Simultaneously, questionnaires of International Index of Erectile Function-Erectile Function (IIEF-EF), Erectile Hard Score (EHS) and Minimal Clinical Important Differences (MCID) were evaluated for the efficiency and safety at 8th and 16th weeks.The changes in the IIEF-EF score by MCID suggested that Li-ESWT treatment was effective in 22 PDE5i nonresponders patients (58%) at 8th week. Then at 16th week the number of patients who were effectively treated increased to 27 (71%). Among PDE5i responders, 5 patients (71%) were effective base on MCID at 16th week. Among PDE5i nonresponders 22 patients (58%) achieved erection hard enough for vaginal penetration and increased to 27 (71%) patients at 16th week (EHS ≥3). Moreover, even 3 patients achieved EHS 4 in PDE5i nonresponders at 16th week. Among PDE5i responders, 4 of 7 patients reached EHS of 4 from EHS 3 at 16th week. Apart from this, Li-ESWT treatment was also effective in 9 patients (24%) in PDE5i nonresponders without follow-up PDE5i.Energy flux density (EFD) of 0.05 of Li-ESWT could improve the erectile function of ED patients with PDE5i response. In addition, EFD of 0.05 of Li-ESWT treatment could turn PDE5i nonresponders to responders.


Subject(s)
Humans , Male , Extracorporeal Shockwave Therapy , Erectile Dysfunction/therapy , Penile Erection , Surveys and Questionnaires
6.
Rev. peru. med. integr ; 4(3): 83-89, 2019. tab, graf
Article in Spanish | LILACS, MTYCI | ID: biblio-1145709

ABSTRACT

Introducción. Corynaea crassa es una planta hemiparásita usada como afrodisíaco en la medicina tradicional. Objetivo. Determinar el efecto erectógeno del extracto etanólico de las raíces de Corynaea crassa (EECC) y selenio en la disfunción sexual inducidas en roedores. Materiales y métodos. Investigación de diseño experimental, preclínico, in vivo, llevado a cabo en el Laboratorio de Farmacología Experimental de la Facultad de Medicina Humana-UNMSM, Lima, Perú. Se emplearon raíces de «viagra macho¼ colectada en el departamento de Cajamarca; ratas machos de dos meses, de 150 ­ 200 g; 42 animales se dividieron al azar en siete grupos: 1). SSF 5 mL/kg; 2). Sildenafilo 5 mg/kg/día; 3). EECC 100mg/kg; grupo 4 EECC 200 mg/kg; grupo 5 EECC 400 mg/kg; grupo 6 EECC 200mg/kg + Se 1 ug/kg y grupo 7 EECC 400 mg/kg + Se 1 ug/kg. Se evaluaron los parámetros del comportamiento sexual, reflejos del pene y nivel de testosterona. Resultados. Por análisis cualitativo se identificaron alcaloides, compuestos fenólicos, esteroides/terpenoides, flavonoides, lactonas, saponinas y taninos. El comportamiento sexual fue dosis dependiente; la administración de 400 mg/kg de EECC + Se 1 ug/kg por vía oral incrementó la frecuencia de monta, en tanto que la dosis de 100 mg/kg aumentó la frecuencia de intromisión (p<0,05), así como los parámetros de los reflejos del pene e incremento significativo de los niveles de testosterona. Conclusiones. Se ha demostrado efecto erectógeno del extracto etanólico de las raíces de Corynaea crassa más selenio en la disfunción sexual inducidas en ratas.


Introduction. Corynaea crassa, a hemiparasitic plant used as an aphrodisiac in traditional medicine. Objective. To determine the erectógeno effect of the ethanolic extract of the roots of Corynaea crassa (EECC) and Selenio in the sexual dysfunction induced in rats. Design. Experimental, Pre-clinical, "In vivo". Setting. Laboratory of Experimental Pharmacology, Faculty of Human Medicine-UNMSM, Lima, Peru. Biological material. Roots of "male Viagra", male rats of 2 months, 150-200 g. Interventions. The plant was collected in the department of Cajamarca; 42 animals divided randomly into 7 groups: 1) SSF 5 mL / kg; 2) Sildenafil 5 mg / kg / day; 3) EECC 100 mg / kg; groups 4 EECC 200mg / kg; groups 5 EECC 400 mg/kg; groups 6 EECC 200 mg / kg + Se 1ug / kg and groups 7 EECC 400 mg / kg + Se 1ug/kg. Main outcome measures. The parameters of sexual behavior, penile reflexes and testosterone level were evaluated. Results. For qualitative analysis, alkaloids, phenolic compounds, steroids / terpenoids, flavonoids, lactones, saponins and tannins were identified. The sexual behavior was dose dependent; the administration of 400 mg / kg of EECC + Se 1ug / kg orally increased the frequency of mounting, while the dose of 100 mg / kg increased the frequency of intrusion (p <0.05), as well as the parameters of the reflexes of the penis and significant increase in testosterone levels. Conclusions. The best results were observed in the doses of 200 mg / kg and 400 mg / kg of the EECC in combination with Selenium.


Subject(s)
Animals , Male , Rats , Selenium , Balanophoraceae , Erectile Dysfunction/therapy , Plants, Medicinal , Plant Extracts , Phytochemicals , Medicine, Traditional
7.
Rev. argent. urol. (1990) ; 83(2): 68-77, 2018. ilus, tab
Article in Spanish | LILACS | ID: biblio-964196

ABSTRACT

Objetivos: los inhibidores de fosfodiesterasa revolucionaron el tratamiento de la disfunción eréctil. Las ondas de choque de baja intensidad emergen como una alternativa terapéutica no invasiva. Materiales y métodos: estudio de cohorte prospectiva y observacional, en el que se evaluó la respuesta de 17 pacientes sexualmente activos al tratamiento con ondas de choque de baja intensidad a los 3 y 6 meses, mediante el Indice Internacional de Función Eréctil (IIEF-6), las preguntas 2 y 3 del Sexual Encounter Profile (SEP-2 y SEP-3), y el Erection Hardness Score (EHS) para evaluar la rigidez peneana, así como una evaluación de satisfacción global con el tratamiento (GAQ) y de recomendación del mismo. Resultados: 6 pacientes presentaban disfunción eréctil leve y 11 disfunción eréctil moderada-severa. Ambos grupos mostraron diferencias estadísticamente significativas en el IIEF-6, SEP-2, SEP-3 y EHS, a los 3 y 6 meses. Sin embargo, no todos los pacientes se mostraron satisfechos o recomendarían el tratamiento, sobre todo en aquellos con disfunción eréctil moderada-severa previo al tratamiento. Conclusión: las ondas de choque de baja intensidad son un tratamiento emergente para la disfunción eréctil, aunque aun sin evidencia clara de su eficacia e indicaciones. Los dispares resultados de los grupos se han debido probablemente a la heterogeneidad de las condiciones basales de los pacientes.(AU)


Objectives: Iphosphodiesterase inhibitors revolutionized the treatment of erectile dysfunction. Low intensity shockwave therapy emerge as a non-invasive therapeutic alternative. Materials and methods: this was a prospective and observational study, in which 17 sexually active patients were evaluated 3 and 6 months after treatment with low intensity shockwave therapy, using the International Index of Erectile Function (IIEF-6), questions 2 and 3 of the Sexual Encounter Profile (SEP-2 and SEP-3), and the Erection Hardness Score (EHS) to assess penile rigidity, as well as a global satisfaction evaluation with the treatment (GAQ) and if they would recommend it to others. Results: 6 patients showed mild erectile dysfunction and 11 moderatesevere erectile dysfunction. Both groups showed statistically significant differences in IIEF-6, SEP-2, SEP-3 and EHS, after 3 and 6 months. However, not all of them were satisfied with the treatment or would recommend it to others, especially those with moderate-severe basal erectile dysfunction. Conclusion: low intensity shockwave therapy is an emergent treatment for erectile dysfunction, although there is no sufficient evidence of its efficacy and indications. The differences between groups were due probably to the heterogeneity of the basal conditions of the patients.(AU)


Subject(s)
Humans , Male , Middle Aged , Aged , Treatment Outcome , Extracorporeal Shockwave Therapy/instrumentation , Extracorporeal Shockwave Therapy/methods , Erectile Dysfunction/therapy , Prospective Studies , Cohort Studies , Erectile Dysfunction/etiology
8.
Int. braz. j. urol ; 43(5): 805-821, Sept.-Oct. 2017. tab, graf
Article in English | LILACS | ID: biblio-892886

ABSTRACT

ABSTRACT Aim: The role of low-intensity extracorporeal shock wave therapy (LI-ESWT) in erectile dysfunction (ED) is not clearly determined. The purpose of this study is to investigate the short-term efficacy and safety of LI-ESWT for ED patients. Materials and Methods: Relevant studies were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), WANFANG and VIP databases. Effective rate in terms of International Index of Erectile Function-Erectile Function Domain (IIEF-EF) and Erectile Hardness Score (EHS) at about 1XSmonth after LI-ESWT was extracted from eligible studies for meta-analysis to calculate risk ratio (RR) of effective treatment in ED patients treated by LI-ESWT compared to those receiving sham-treatment. Results: Overall fifteen studies were included in the review, of which four randomized controlled trials (RCTs) were for meta-analysis. Effective treatment was 8.31 [95°/o confidence interval (CI): 3.88-17.78] times more effective in the LI-ESWT group (n=176) than in the sham-treatment group (n= 101) at about 1 month after the intervention in terms of EHS, while it was 2.50 (95% CI: 0.74-8.45) times more in the treatment group (n= 121) than in the control group (n=89) in terms of IIEF-EF. Nine-week protocol with energy density of 0.09mJ/mm2 and 1500 pluses seemed to have better therapeutic effect than five-week protocol. No significant adverse event was reported. Conclusion: LI-ESWT, as a noninvasive treatment, has potential short-term therapeutic effect on patients with organic ED irrespective of sensitivity to PDE5is. Owing to the limited number and quality of the studies, more large-scale, well-designed and longterm follow-up time studies are needed to confirm our analysis.


Subject(s)
Humans , Male , High-Intensity Focused Ultrasound Ablation/methods , Erectile Dysfunction/therapy , Randomized Controlled Trials as Topic , Treatment Outcome , High-Intensity Focused Ultrasound Ablation/adverse effects
9.
Int. braz. j. urol ; 41(5): 967-974, Sept.-Oct. 2015. tab, graf
Article in English | LILACS | ID: lil-767055

ABSTRACT

ABSTRACT The primary goal in the management strategy of a patient with ED would be to determine its etiology and cure it when possible, and not just to treat the symptoms alone. One of the new therapeutic strategies is the use of low intensity extracorporeal shockwave (LISW) therapy. The mechanism of shockwave therapy is not completely clear. It is suggested that LISW induces neovascularization and improvement of cavernosal arterial flow which can lead to an improvement of erectile function by releasing NO, VEGF and PCNA. Materials and Methods: 31 patients between February and June 2013 with mild to severe ED and non-Phosphodiesterase 5 inhibitors responders were enrolled. Patients underwent four weekly treatment sessions. During each session 3600 shocks at 0.09mJ/ mm2 were given, 900 shocks at each anatomical area (right and left corpus cavernosum, right and left crus). Improvement of the erectile function was evaluated using the International Index of Erectile Function (IIEF-EF), the Sexual Encounter Profile (SEP) diaries (SEP-Questions 2 and 3) and Global Assessment Questions (GAQ-Q1 and GAQ-Q2). Results: At 3-month follow-up IIEF-EF scores improved from 16.54±6.35 at baseline to 21.03±6.38. Patients answering ‘yes’ to the SEP-Q2 elevated from 61% to 89% and from 32% to 62% in the SEP-Q3. A statistically significant improvement was reported to the Global Assessment Questions (GAQ-Q1 and GAQ-Q2). Conclusion: In conclusion, we can affirm that LISW is a confirmed therapeutic approach to erectile dysfunction that definitely needs more long-term trials to be clarified and further verified.


Subject(s)
Aged , Humans , Male , Middle Aged , Erectile Dysfunction/therapy , Lithotripsy/methods , Follow-Up Studies , Neovascularization, Physiologic , Nitric Oxide Synthase/analysis , Patient Satisfaction , Penile Erection/physiology , Proliferating Cell Nuclear Antigen/analysis , Reproducibility of Results , Self Report , Severity of Illness Index , Time Factors , Treatment Outcome , Vascular Endothelial Growth Factor A/analysis
10.
Korean Journal of Urology ; : 197-204, 2015.
Article in English | WPRIM | ID: wpr-60934

ABSTRACT

PURPOSE: Electroporation is known to enhance the efficiency of gene transfer through a transient increase in cell membrane permeability. The aim of this study was to determine the optimal conditions for in vivo electroporation-mediated gene delivery into mouse corpus cavernosum. MATERIALS AND METHODS: Diabetes was induced in C57BL/6 mice by intraperitoneal injections of streptozotocin. After intracavernous injection of pCMV-Luc (100 microg/40 microL), different electroporation settings (5-50 V, 8-16 pulses with a duration of 40-100 ms) were applied to the penis to establish the optimal conditions for electroporation. Gene expression was evaluated by luciferase assay. We also assessed the undesired consequences of electroporation by visual inspection and hematoxylin-eosin staining of penile tissue. RESULTS: Electroporation profoundly induced gene expression in the corpus cavernosum tissue of normal mice in a voltage-dependent manner. We observed electrical burn scars in the penis of normal mice who received electroporation with eight 40-ms pulses at a voltage of 50 V and sixteen 40-ms pulses, eight 100-ms pulses, and sixteen 100-ms pulses at a voltage of 30 V. No detectable burn scars were noted in normal mice stimulated with eight 40-ms pulses at a voltage of 30 V. Electroporation also significantly induced gene expression in diabetic mice stimulated with 40-ms pulse at a voltage of 30 V without injury to the penis. CONCLUSIONS: We have established the optimal electroporation conditions for maximizing gene transfer into the corpus cavernosum of mice while avoiding damage to the erectile tissue. The electroporation-mediated gene delivery technique will be a valuable tool for gene therapy in the field of erectile dysfunction.


Subject(s)
Animals , Diabetes Mellitus, Experimental/complications , Electroporation/methods , Erectile Dysfunction/therapy , Gene Expression , Gene Transfer Techniques , Genes, Reporter , Genetic Therapy/methods , Luciferases/metabolism , Male , Mice , Mice, Inbred C57BL , Penile Erection/physiology , Penis/physiopathology , Transfection
12.
Oman Medical Journal. 2014; 29 (1): 46-50
in English | IMEMR | ID: emr-138200

ABSTRACT

Hypotestosteronemia has been reported in approximately half of type 2 diabetic men in general. This study aims to assess serum total testosterone levels in type 2 diabetics with erectile dysfunction and to correlate the degree of improvement between sildenafil citrate and testosterone levels. A cross sectional and prospective comparative interventional study was conducted at the Diabetic Clinic of Assalam Teaching Hospital in Mosul, during the period from January 1, 2009 through to December 31, 2011. The study enrolled 120 type 2 diabetic males with erectile dysfunction who were analyzed with regard to age, duration of diabetes, duration and severity of erectile dysfunction, serum total testosteron levels and the degree of response to sildenafil citrate in terms of testosterone levels. The data were statistically analyzed using the independent two-sample Student t test, X[2] test and Pearson correlation test. A jp-value of <0.05 was considered statistically significant. Thirty six percent of type 2 diabetic males with erectile dysfunction were found to have low serum testosterone levels. Hie hypotestosteronemic and normotestosteronemic subgroups were not significantly different in terms of mean age, duration of diabetes, reduction of libido, and reduction in erectile function. The rate and the degree of improvement of erection by sildenafil in the normo-and-hypotestosteronemic respondents were not significantly different, but the degree of improvement by sildenafil was significantly correlated to testosterone levels among the hypotestosteronemic group. Hypotestosteronemia was found in 36% of type 2 diabetic males with erectile dysfunction. The degree of improvement of erectile dysfunction by sildenafil was directly proportional to the serum testosterone levels among the hypotestosteronemic group. Therapeutic supplement with testosterone preparation in the hypotestosteronemic diabetics with erectile dysfunction may improve their response to sildenafil


Subject(s)
Humans , Male , Piperazines/pharmacology , Diabetes Complications , Erectile Dysfunction/therapy , Testosterone/blood , Cross-Sectional Studies
13.
J. vasc. bras ; 11(4): 317-319, out.-dez. 2012. ilus
Article in Portuguese | LILACS | ID: lil-659727

ABSTRACT

A disfunção erétil (DE) representa um distúrbio comum de caráter multifatorial. Os autores relatam um caso de paciente vítima de trauma perineal evoluindo com DE por fístula da artéria bulbar para o corpo esponjoso peniano, promovendo um shunt arteriovenoso culminando com déficit de ereção, congestão peniana e dor. O mesmo foi submetido ao tratamento endovascular por embolização com sucesso e encontra-se no sexto mês de acompanhamento ambulatorial, com retorno às suas atividades sexuais e sem queixas de rigidez peniana e dor.


The erectile dysfunction (ED) is a common multifactorial disorder . The authors report a case of perineal trauma patients with evolving secondary bulbar penile artery fistula to the spongy body, promoting an arteriovenous shunt culminating with a deficit of erection, congestion and penile pain. The same was treated by endovascular embolization with success and is in 6¢ªmonths of follow up with return to sexual activity and no complaints of penile rigidity and pain.


Subject(s)
Humans , Male , Middle Aged , Erectile Dysfunction/therapy , Embolization, Therapeutic/nursing , Endovascular Procedures/rehabilitation , Fistula
14.
Int. braz. j. urol ; 38(6): 833-841, Nov-Dec/2012. graf
Article in English | LILACS | ID: lil-666025

ABSTRACT

Objectives

To evaluate the effect of mesenchymal stem cells (MSCs) and MSCs mixed with Matrixen as a cell carrier on the erectile dysfunction caused by bilateral cavernous nerve crushing injury. Materials and Methods

White male Sprague-Dawley rats were divided into 4 groups: sham-operated control group (n = 5), bilateral cavernous nerve crushing group (BCNC group, n = 10), BCNC administered with MSCs group (n = 10,1×106 in 20 µL), BCNC administered with Matrixen group (n = 10.1×106 in 20 µL), BCNC administered with MSCs/Matrixen group (n = 10.1×106 in 20 µL). After functional assessment at 4 weeks, major pelvic ganglion (MPG) and penile tissue were collected. Immunofluorescent staining of MPG was performed with PKH26 and Tuj1. Western blot analysis of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) were done in corpus cavernosum. Results

ICP/MAP ratios of BCNC with MSCs and MSCs/Matrixen groups were significantly increased compared with BCNC and BCNC with Matrixen group. Moreover, ICP/MAP ratios of MSCs/Matrixen group were significantly increased compared with BCNC with MSCs group. In MPG, the more implantation of MSCs and increased expression of nerve cells were observed in MSCs/Matrixen group compared with BCNC with MSCs group. Significant increase expression of eNOS and nNOS was also noted in BCNC with MSCs/Matrixen group. Conclusion

The erectile function was more preserved in MSCs/Matrixen group compared with the administration of MSCs alone in the rats with bilateral cavernous nerve crushing injury. Therefore, we consider that the use of transplant cell carrier such as Matrixen may help the implantation of MSCs and improve the therapeutic effect of MSCs. .


Subject(s)
Animals , Male , Rats , Erectile Dysfunction/therapy , Mesenchymal Stem Cell Transplantation , Penis/innervation , Blotting, Western , Erectile Dysfunction/etiology , Fluorescent Antibody Technique , Models, Animal , Nitric Oxide Synthase Type I/analysis , Nitric Oxide Synthase Type III/analysis , Penile Erection/drug effects , Penis/drug effects , Rats, Sprague-Dawley , Treatment Outcome
15.
Mediciego ; 18(n.esp)dic. 2012. tab
Article in Spanish | LILACS | ID: lil-710846

ABSTRACT

Se realizó un ensayo clínico fase II, antes-después controlado, cuya fase ejecutiva se extendió desde el primero de enero del 2010 hasta el treinta de agosto del 2011 con todos los pacientes que acudieron remitidos desde los consultorios médicos de la familia y de la consulta de Psiquiatría del área norte de Morón con diagnóstico de disfunción sexual eréctil a la consulta de Medicina Natural y Tradicional creada para los efectos, con el objetivo de evaluar la efectividad de la acupuntura, de la homeopatía combinada con terapia floral y de implantación de Catgut en el tratamiento de esta entidad. La muestra estuvo constituida por 90 pacientes que conformaron 3 grupos de 30 pacientes cada uno los cuales recibieron el tratamiento escogido de forma aleatoria simple. La disfunción eréctil fue más frecuente en pacientes de 19 a 29 años, de la raza blanca, casados, y con vínculo laboral, predominó en pacientes con diabetes mellitus, el hábito de fumar y la ingestión de psicofármacos. En cuanto al diagnóstico tradicional incidieron la deficiencia de Yang de riñón y la desarmonía corazón-riñón. La implantación de Catgut resultó ser la más efectiva, y mucho más en los pacientes con evolución aguda y moderada.


Subject(s)
Humans , Male , Adult , Acupuncture Therapy , Catgut , Erectile Dysfunction/therapy , Homeopathy , Clinical Trials, Phase II as Topic
16.
RBM rev. bras. med ; 69(3)mar. 2012.
Article in Portuguese | LILACS | ID: lil-621007

ABSTRACT

Uma grande revolução no tratamento da disfunção erétil, especialmente após o desenvolvimento dos primeiros inibidores da 5-fosfodiesterase (5-PDE), no final dos anos 90, marcou profundamente a história da sexualidade humana, repercutindo sobretudo na população de difícil tratamento (diabetes mellitus, prostatectomizados por câncer e outros casos de disfunção orgânica). Respeitando a estratégia de tratamento de cada urologista, os pacientes devem ser estimulados a experimentar todos os tipos de inibidores da 5-PDE disponíveis. Na falha da farmacoterapia oral, ou quando houver contraindicação para ela, dever-se-á considerar a injeção intracavernosa e, finalmente, implante cirúrgico de prótese peniana.


Subject(s)
Humans , Male , Adult , Middle Aged , Erectile Dysfunction/diagnosis , Erectile Dysfunction/therapy
17.
Rev. bras. cardiol. (Impr.) ; 24(3): 180-185, maio-jun. 2011.
Article in Portuguese | LILACS | ID: lil-599022

ABSTRACT

A disfunção erétil é definida como a incapacidade persistente em manter uma ereção suficiente para a satisfação sexual, sendo considerada importante problema de saúde pública. Sua prevalência aumenta com a idade, mas principalmente se associada aos fatores de risco para a saúde cardiovascular como obesidade, tabagismo, hipertensão, diabetes e sedentarismo. Em contrapartida, a prática regular de exercícios físicos apresenta forte associação com a função sexual e deve ser indicada para o controle dos fatores de risco e disfunção erétil.


Characterized as the persistent inability to maintain an erection sufficient for sexual satisfaction, erectile dysfunction is rated as an important public healthissue. Its prevalence increases with age, associated mainly with cardiovascular risk factors such as obesity, smoking, hypertension, diabetes and physicalinactivity. In contrast, regular physical exercise is strongly associated with sexual functions and should be indicated for the control of risk factors and erectiledysfunction.


Subject(s)
Humans , Male , Age Factors , Erectile Dysfunction/therapy , Risk Factors , Exercise Therapy/methods , Exercise Therapy , Hypertension/complications , Obesity/complications , Tobacco Use Disorder/adverse effects
18.
20.
Salud(i)ciencia (Impresa) ; 17(2): 148-151, oct. 2009.
Article in Spanish | LILACS | ID: lil-594168

ABSTRACT

En hombres con apnea obstructiva del sueño y enfermedad pulmonar obstructiva crónica (síndrome superpuesto) la disfunción eréctil es un motivo de consulta frecuente. La evidencia señala una relación etiológica, por lo tanto el tratamiento de los trastornos respiratorios mejoraría la función eréctil. Cuarenta y ocho hombres con síndrome superpuesto y disfunción eréctil fueron tratados de manera convencional mediante presión continua positiva de las vías aéreas y broncodilatadores durante seis meses. El puntaje que medía la intensidad de la disfunción eréctil mejoró significativamente en toda la población en estudio. Cuando se utilizó el criterio clínico de mejoría de por lo menos 5 puntos de aumento en el puntaje de la intensidad de la disfunción eréctil sólo 12 pacientes (25%) lo lograron. Un porcentaje significativo de los pacientes sin respuesta, o que no estaban satisfechos con el manejo convencional respondieron a la ingesta de sildenafil a demanda. Si bien el mejoramiento de la función respiratoria generalmente se acompañaba de una mejora en la función eréctil, debería considerarse el tratamiento específico de la disfunción eréctil si la satisfacción del paciente es la meta del tratamiento.


In men with obstructive sleep apnea and chronic obstructive pulmonary disease (overlap syndrome), erectile dysfunction is a frequent complaint. Evidence suggests an etiologic link, and therefore treatment of breathing disorders would improve erectile function. Forty-eight men with overlap syndrome and erectiledysfunction were treated conventionally with continuous positive airway pressure and bronchodilators for 6 months. Erectile dysfunction intensity score improved significantly in the entire study population. When the clinical improvement criterion of at least a 5-point increase in erectile dysfunction intensity score was used only 12 patients (25%) responded. A significantpercentage of patients whose erectile dysfunction did not respond, or who were not satisfied with conventionalmanagement, responded to on-demand sildenafil. Even though improvements in respiratory function generally improve erectile function, specific ED treatment may be considered if patient satisfaction is the treatment goal.


Subject(s)
Humans , Male , Adult , Middle Aged , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/therapy , Erectile Dysfunction/diagnosis , Erectile Dysfunction/therapy , Pulmonary Disease, Chronic Obstructive/complications , Pulmonary Disease, Chronic Obstructive/therapy , Phosphodiesterase Inhibitors
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