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2.
An. bras. dermatol ; 95(3): 376-378, May-June 2020. graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1130870

ABSTRACT

Abstract A 44-year-old male patient presented with nodules that evolved with inflammation, following drainage of seropurulent secretion and ulceration. The patient had a 6 year-history of alcohol addiction and reported contact with cats. At the physical examination, the patient had skin-colored and erythematous nodules, and ulcers covered with thick, blackened crusts on the face, trunk and limbs. A culture of a nodule fluid revealed growth of Sporotrix sp. He also had pulmonary involvement and therefore the disease was classified as systemic sporotrichosis, a rare form that usually affect patients infected with HIV. Chronic alcohol abuse was considered the factor of immunosuppression for the patient.


Subject(s)
Humans , Male , Adult , Sporotrichosis/immunology , Sporotrichosis/pathology , Immunocompromised Host , Alcoholism/complications , Alcoholism/immunology , Immunocompetence , Sporotrichosis/chemically induced , Sporothrix/isolation & purification , Erythema/immunology , Erythema/pathology
4.
An. bras. dermatol ; 95(2): 250-251, Mar.-Apr. 2020. graf
Article in English | ColecionaSUS, LILACS, ColecionaSUS | ID: biblio-1130839

ABSTRACT

Abstract Gamasoidosis is a poorly known and underdiagnosed mite infestation. It is characterized by the presence of erythematous and flattened papules that are quite pruritic, and can affect any region of the body, with preference for areas of folds. This article reports a case of the disease caused by mites of the species Dermanyssus gallinae. Increasingly, the agents that cause this disease are found in urban environments, increasing the incidence of people affected by the disease. This dermatosis has a self-limiting clinical picture and the treatment is done with the use of topical corticosteroids and oral antihistamines.


Subject(s)
Humans , Animals , Male , Aged , Pruritus/pathology , Erythema/pathology , Forearm/pathology , Mite Infestations/pathology , Pruritus/parasitology , Birds/parasitology , Dermoscopy , Erythema/parasitology , Forearm/parasitology , Mite Infestations/parasitology , Mites
5.
An. bras. dermatol ; 95(1): 67-70, Jan.-Feb. 2020. graf
Article in English | LILACS | ID: biblio-1088720

ABSTRACT

Abstract Erythroderma as the first manifestation of a solid organ malignancy is rare. The underlying cancer is a challenging condition to diagnose. There are a few cases of erythroderma in cancer patients reported in the literature. We here describe the case of a 70-year-old man who presented with asthenia, weight loss, dry cough and total body erythema with desquamation over the past month. A chest computed tomography scan showed a nodular lesion, which was finally diagnosed as a squamous cell lung carcinoma. To our knowledge, as an erythroderma presentation, only 13 cases have been reported in the literature. This case report demonstrates the need to search for a neoplasm in patients presenting with erythroderma, particularly in the presence of accompanying debilitating symptoms.


Subject(s)
Humans , Male , Aged , Dermatitis, Exfoliative/pathology , Neoplasms, Squamous Cell/pathology , Lung Neoplasms/pathology , Paraneoplastic Syndromes/pathology , Biopsy , Tomography, X-Ray Computed , Dermatitis, Exfoliative/etiology , Neoplasms, Squamous Cell/complications , Erythema/pathology , Lung Neoplasms/complications
6.
An. bras. dermatol ; 95(1): 98-101, Jan.-Feb. 2020. graf
Article in English | LILACS | ID: biblio-1088724

ABSTRACT

Abstract Pachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy (PHO) is a rare hereditary disease characterized by digital clubbing, pachydermia, and periostosis. Its pathogenesis is uncertain and the diagnosis is based on clinical and radiological data. A complete form of the syndrome is reported in a male patient with disease onset in adolescence, with compatible clinical and radiological findings, presenting the three cardinal findings as well as other associated manifestations, such as hyperhidrosis and acne.


Subject(s)
Humans , Male , Young Adult , Osteoarthropathy, Primary Hypertrophic/pathology , Scalp Dermatoses/pathology , Erythema/pathology
8.
An. bras. dermatol ; 94(6): 717-720, Nov.-Dec. 2019. graf
Article in English | LILACS | ID: biblio-1054891

ABSTRACT

Abstract Confluent and reticulated papillomatosis of Gougerot and Carteaud is a rare dermatosis with onset during puberty, more prevalent in females than in males. The pathogenesis is unknown, but some theories suggest either a keratinization or endocrine disorder. The lesions are verrucous, brownish, hyperkeratotic papules or spots that coalesce in a confluent and/or reticulated pattern. This report presents a case with extensive cutaneous involvement associated with acanthosis nigricans and good response to treatment with methotrexate.


Subject(s)
Humans , Male , Adolescent , Papilloma/pathology , Papilloma/drug therapy , Skin Neoplasms/pathology , Skin Neoplasms/drug therapy , Methotrexate/therapeutic use , Dermatologic Agents/therapeutic use , Biopsy , Treatment Outcome , Erythema/pathology
10.
An. bras. dermatol ; 94(5): 608-611, Sept.-Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1054872

ABSTRACT

Abstract Dissecting cellulitis is an inflammatory, chronic, and recurrent disease of the hair follicles that mainly affects young Afro-descendent men. Trichoscopy is a method of great diagnostic value for disorders of the scalp. Clinical and trichoscopic findings of dissecting cellulitis are heterogeneous and may present features common to non-cicatricial and scarring alopecia. This article presents the trichoscopic findings of dissecting cellulitis that help in the diagnosis and consequent institution of the appropriate therapy and better prognosis of the disease.


Subject(s)
Humans , Scalp Dermatoses/diagnostic imaging , Cellulitis/pathology , Cellulitis/diagnostic imaging , Hair Follicle/pathology , Hair Follicle/diagnostic imaging , Dermoscopy/methods , Scalp Dermatoses/pathology , Skin Diseases, Genetic/pathology , Skin Diseases, Genetic/diagnostic imaging , Erythema/diagnosis , Erythema/pathology , Hair/pathology , Hair/diagnostic imaging
13.
An. bras. dermatol ; 94(4): 388-398, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1038294

ABSTRACT

Abstract: Paraneoplastic pemphigus is a rare and severe autoimmune blistering disease characterized by mucocutaneous lesions associated with benign and malignant neoplasms. Diagnostic criteria include the presence of chronic mucositis and polymorphic cutaneous lesions with occult or confirmed neoplasia; histopathological analysis exhibiting intraepidermal acantholysis, necrotic keratinocytes, and vacuolar interface dermatitis; direct immunofluorescence with intercellular deposits (IgG and C3) and at the basement membrane zone (IgG); indirect immunofluorescence with intercellular deposition of IgG (substrates: monkey esophagus and simple, columnar, and transitional epithelium); and, autoreactivity to desmogleins 1 and 3, desmocollins 1, 2, and 3, desmoplakins I and II, envoplakin, periplakin, epiplakin, plectin, BP230, and α-2-macroglobulin-like protein 1. Neoplasias frequently related to paraneoplastic pemphigus include chronic lymphocytic leukemia, non-Hodgkin lymphoma, carcinomas, Castleman disease, thymoma, and others. Currently, there is no standardized treatment for paraneoplastic pemphigus. Systemic corticosteroids, azathioprine, mycophenolate mofetil, cyclosporine, rituximab, cyclophosphamide, plasmapheresis, and intravenous immunoglobulin have been used, with variable outcomes. Reported survival rates in 1, 2, and 5 years are 49%, 41%, and 38%, respectively.


Subject(s)
Humans , Paraneoplastic Syndromes/pathology , Paraneoplastic Syndromes/therapy , Pemphigus/immunology , Pemphigus/pathology , Pemphigus/therapy , Paraneoplastic Syndromes/immunology , Skin/pathology , Autoantibodies/immunology , Pemphigus/diagnosis , Erythema/diagnosis , Erythema/pathology , Mouth Diseases/diagnosis , Mouth Diseases/pathology
14.
An. bras. dermatol ; 94(4): 446-448, July-Aug. 2019. graf
Article in English | LILACS | ID: biblio-1038296

ABSTRACT

Abstract: Necrolytic acral erythema is a distinct erythema that has been described as an extrahepatic manifestation of hepatitis C virus infection. Most reported cases have been in Africa, especially Egypt. We report the first case (to the best of our knowledge) of necrolytic acral erythema in a Chinese patient with HCV and HBV coinfection. We aim to increase awareness for recognizing this condition in the Chinese population.


Subject(s)
Humans , Male , Adult , Hepatitis C/complications , Erythema/pathology , Erythema/virology , Coinfection/complications , Hepatitis B/complications , China , Hepatitis C/pathology , Extremities/pathology , Coinfection/pathology , Hepatitis B/pathology , Necrosis/virology
15.
An. bras. dermatol ; 94(2): 164-171, Mar.-Apr. 2019. tab, graf
Article in English | LILACS | ID: biblio-1001151

ABSTRACT

Abstract BACKGROUND: Tacrolimus, for its activity on modulation of collagen production and fibroblast activity, may have a role in the prevention of hypertrophic scars. OBJECTIVES: Evaluate macroscopic, microscopic, metabolic, laboratory effects and side effects of the use of topical tacrolimus ointment, in different concentrations, in the prevention of hypertrophic scars. METHODS: Twenty-two rabbits were submitted to the excision of 2 fragments of 1 cm of each ear, 4 cm apart, down to cartilage. The left ear of the animals was standardized as control and Vaseline applied twice a day. The right ear received tacrolimus ointment, at concentrations of 0.1% on the upper wound and 0.03% on the lower wound, also applied twice a day. Macroscopic, microscopic, laboratory criteria and the animals' weight were evaluated after 30 days of the experiment. RESULTS: Wounds treated with tacrolimus, at concentrations of 0.1% and 0.03%, when compared to control, showed a lower average degree of thickening (p = 0.048 and p <0.001, respectively). The average of scar thickness and lymphocyte, neutrophil and eosinophil concentrations are lower in the treated wounds compared to the control (p <0.001, p=0.022, p=0.007, p=0.044, respectively). The mean concentration of lymphocytes is lower in wounds treated with a higher concentration of the drug (p=0.01). STUDY LIMITATIONS: experiment lasted only 30 days. CONCLUSIONS: Tacrolimus at the 2 concentrations evaluated reduced the severity of inflammatory changes and positively altered the macroscopic aspect of the scar in the short term. Its use was shown to be safe, with no evidence of systemic or local adverse effects.


Subject(s)
Animals , Male , Rabbits , Tacrolimus/therapeutic use , Calcineurin Inhibitors/therapeutic use , Ointments , Urea/blood , Serum Albumin/analysis , Serum Albumin/drug effects , Administration, Topical , Tacrolimus/administration & dosage , Tacrolimus/pharmacology , Cicatrix, Hypertrophic/pathology , Cicatrix, Hypertrophic/prevention & control , Lymphocyte Count , Creatinine/blood , Alanine Transaminase/drug effects , Alanine Transaminase/blood , Disease Models, Animal , Ear, External/pathology , Erythema/pathology , Calcineurin Inhibitors/administration & dosage , Calcineurin Inhibitors/pharmacology , Inflammation/pathology , Inflammation/prevention & control
16.
An. bras. dermatol ; 94(1): 99-101, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-983747

ABSTRACT

Abstract: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder is a rare disease, with an indolent evolution and benign course. The classic presentation is a solitary nodule on the face or trunk. The disorder's rarity and clinical and histopathological characteristics, can make the diagnosis difficult. We present the case of a 36-year-old Caucasian woman with a purplish erythematous nodule, hardened, shiny, asymptomatic, on the left nasal ala, which had grown progressively for 45 days. Histopathological examination and immunohistochemistry panel demonstrated alterations consistent with primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder. There was complete remission of the condition within 60 days of treatment with potent occlusive corticosteroids.


Subject(s)
Humans , Female , Adult , CD4-Positive T-Lymphocytes/pathology , Erythema/pathology , Lymphoproliferative Disorders/pathology , Skin Neoplasms/pathology , Immunohistochemistry , Lymphoma, T-Cell, Cutaneous/pathology
18.
Rev. Assoc. Med. Bras. (1992) ; 64(6): 492-497, June 2018. graf
Article in English | LILACS | ID: biblio-956479

ABSTRACT

SUMMARY Erysipelatoid Carcinoma (EC), also known as Inflammatory Metastatic Carcinoma, is a rare form of cutaneous metastasis, secondary to an internal malignancy, more often related to breast cancer. Clinically, the lesion has a well-marked, bound erythematous appearance, much like an infectious process, such as erysipelas and cellulitis, these being the most common differential diagnoses. It is characterized by an acute or subacute appearance with an erythematous plaque, sometimes hot and painful, being more often situated in the primary tumor vicinity, especially in the thorax wall in the region of a mastectomy due to breast cancer. Here we present the case of a 75-year-old patient with ductal infiltrated carcinoma for 3 years, who presented an acute erythematous and infiltrated plaque in the region of a previous mastectomy, with a final diagnosis of EC.


Subject(s)
Humans , Female , Aged , Skin Neoplasms/secondary , Carcinoma, Ductal, Breast/secondary , Erysipeloid/pathology , Inflammatory Breast Neoplasms/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Thorax , Breast , Breast Neoplasms/surgery , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Diagnosis, Differential , Erysipeloid/diagnosis , Erythema/pathology
19.
An. bras. dermatol ; 93(2): 291-293, Mar.-Apr. 2018. graf
Article in English | LILACS | ID: biblio-887193

ABSTRACT

Abstract: Multinucleate cell angiohistiocytoma is a rare idiopathic benign fibrohistiocytic and vascular proliferation usually presenting as multiple asymptomatic papules, red to violaceous in colour, primarily located on the extremities of middle-aged females. This entity is probably underdiagnosed due to the lack of recognition by clinicians and pathologists. We describe a patient with a multinucleate cell angiohistiocytoma of the face, a less frequent localization, in order to increase awareness of this entity and elucidate its clinical, histopathological, and immunohistochemistry features.


Subject(s)
Humans , Female , Middle Aged , Skin Neoplasms/pathology , Facial Neoplasms/pathology , Histiocytoma, Benign Fibrous/pathology , Skin Neoplasms/diagnosis , Biopsy , Facial Neoplasms/diagnosis , Cheek/pathology , Histiocytoma, Benign Fibrous/diagnosis , Erythema/pathology
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