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1.
Univ. salud ; 23(1): 64-70, ene.-abr. 2021. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1157010

ABSTRACT

Resumen Introducción: Las manifestaciones clínicas más frecuentes causadas por el Herpes Virus Humano Tipo 6 (HHV-6) ocurren en niños menores de 2 años, presentan lesiones en piel tipo roséola o exantema súbito. En adultos, las manifestaciones clínicas relacionadas a HHV-6 son muy variables, y pueden sobreponerse con otras afecciones. Objetivo: Presentar una serie de casos de pacientes diagnosticados con infección activa por HHV-6, quienes mostraban manifestaciones neurológicas, dermatológicas y de fatiga crónica. Materiales y métodos: Se realizó análisis de historias clínicas de 6 pacientes que fueron diagnosticados con infección activa por HHV-6, a través de métodos moleculares. Resultados: Se reportan 6 pacientes que fueron diagnosticados con infección activa por HHV-6 mediante métodos moleculares, quienes presentaron manifestaciones clínicas comunes tales como: fiebre, cefalea, depresión, decaimiento, pérdida de memoria y concentración, dolor fibromuscular, dolor poliarticular, sueño no reparador, exantema, nevus rubí, liquen plano y parestesias. Conclusiones: A través de esta serie de casos se espera resaltar la importancia de identificar la infección activa por HHV-6 a través de métodos moleculares, y sensibilizar a la comunidad médica sobre el papel que juega el virus en la evolución de diversas patologías.


Abstract Introduction: The most frequent clinical manifestations of Human Herpesvirus 6 (HHV-6) in children under 2 years of age are roseola-like skin lesions and sudden rash. In adults, the clinical manifestations associated with HHV-6 are highly variable and can overlap with other conditions. Objective: To present a case series of patients diagnosed with active HHV-6 infection, who showed neurological, dermatological and chronic fatigue manifestations. Materials and methods: An analysis of medical records of 6 patients who were diagnosed with active HHV-6 infection through molecular methods was performed. Results: 6 patients were diagnosed with active HHV-6 infection using molecular methods, who had common clinical manifestations such as fever, headache, depression, tiredness, loss of memory and concentration, fibromuscular pain, polyarticular pain, nonrestorative sleep, rash, ruby nevus, lichen planus and paresthesia. Conclusions: This case series highlights the importance of identifying active HHV-6 infection through molecular methods and creating awareness in the medical community of the role that the virus plays on the development of diverse pathologies.


Subject(s)
Herpesvirus 6, Human , Skin Diseases , Fatigue Syndrome, Chronic , Viral Load
2.
Article in Chinese | WPRIM | ID: wpr-877603

ABSTRACT

OBJECTIVE@#To observe the effect of ginger-separated moxibustion on fatigue state and intestinal flora in patients with chronic fatigue syndrome (CFS).@*METHODS@#A total of 62 patients with CFS were randomly divided into an observation group (31 cases, 3 cases dropped off) and a control group (31 cases, 2 cases dropped off). The patients in the control group were treated with normal diet and moderate exercise; on the basis of the control group, the patients in the observation group were treated with ginger-separated moxibustion at Zhongwan (CV 12), Shenque (CV 8) and Guanyuan (CV 4), 30 min each time, once every other day, three times a week. Both groups were intervened for 4 weeks. Before and after treatment, the fatigue scale-14 (FS-14) was used to observe the improvement of fatigue state, and 16S rRNA detection technology was used to detect the distribution of intestinal flora.@*RESULTS@#Compared before treatment, the FS-14 score was reduced after treatment in the observation group (@*CONCLUSION@#The ginger-separated moxibustion could significantly improve the fatigue state in CFS patients, which may be related to the regulation of intestinal flora structure and the repair of intestinal barrier.


Subject(s)
Acupuncture Points , Fatigue Syndrome, Chronic/therapy , Gastrointestinal Microbiome , Ginger , Humans , Moxibustion , RNA, Ribosomal, 16S
3.
Rev. medica electron ; 42(3): 1882-1888, mayo.-jun. 2020.
Article in Spanish | LILACS, CUMED | ID: biblio-1127048

ABSTRACT

RESUMEN Se supone que aproximadamente 80 millones de personas a nivel mundial están infectadas con el virus de la hepatitis C. Un aproximado del 60 % de dichos pacientes aqueja síndrome de fatiga crónica. Se presentó un paciente portador de hepatitis crónica de tipo C, con manifestaciones clínicas de síndrome de fatiga crónica por más de dos años. Se han reportado estudios internacionales que han demostrado la relación existente entre el desarrollo de la respuesta inmune y el daño que ocasiona en el tejido cerebral la infección por virus de hepatitis C. Este trabajo tiene como objetivo la presentación del primer caso que se tiene referencia (AU).


ABSTRACT It is believed that almost 80 million persons are infected with the Hepatitis C virus around the world, and 60 % of them suffer the chronic fatigue syndrome. For that reason we present the case of a patient who is a carrier of the chronic fatigue syndrome for more than two years. Reports of international research have showed the relation between the immune answer and the damage caused by the infection of the hepatitis C virus in the brain tissues. The aim of this work is presenting the first case reported in Cuba (AU).


Subject(s)
Humans , Male , Fatigue Syndrome, Chronic/etiology , Hepatitis C/complications , Antiviral Agents/therapeutic use , Quality of Life , Fatigue Syndrome, Chronic/drug therapy , Interferons/adverse effects , Interferons/therapeutic use , Hepatitis C/drug therapy , Hepatitis C/epidemiology , Antibody Formation
4.
Rev. Hosp. Ital. B. Aires (2004) ; 39(4): 128-134, dic. 2019.
Article in Spanish | LILACS | ID: biblio-1099754

ABSTRACT

Asociada o no a una enfermedad orgánica, la depresión tiene gran prevalencia en la práctica médica pero es subdiagnosticada. El trastorno del ánimo suele coexistir con variadas quejas somáticas y dolores crónicos, configurando síndromes mixtos con un diagnóstico diferencial complejo. En este artículo se describen distintas presentaciones clínicas de la depresión en medicina general, con énfasis en los estados depresivos atípicos, depresiones enmascaradas muy relevantes por su frecuencia y consecuencias: depresión posquirúrgica, cuadros dolorosos crónicos como cefaleas o lumbago, la fatiga crónica y la fibromialgia. Solo el reconocimiento y diagnóstico de la depresión subyacente posibilitará la implementación de las adecuadas intervenciones terapéuticas. Se revisan también algunas recomendaciones para el uso de antidepresivos en atención primaria y la eventual consulta psiquiátrica. (AU)


Associated or not with an organic disease, depression has a high prevalence in medical practice but is underdiagnosed. The mood disorder usually coexists with varied somatic complaints and chronic pain, forming mixed syndromes with a complex differential diagnosis. This article describes different clinical presentations of depression in general medicine, with emphasis on atypical depressive states, masked depressions very relevant for their frequency and consequences: post-surgical depression, chronic painful conditions such as headaches or lumbago, chronic fatigue and fibromyalgia. Only the recognition and diagnosis of the underlying depression will enable the implementation of appropriate therapeutic interventions. Some recommendations for the use of antidepressant drugs in primary care and the eventual psychiatric consultation are also reviewed. (AU)


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Young Adult , Primary Health Care/trends , Depression/diagnosis , Psychiatry/trends , Signs and Symptoms , Somatoform Disorders/diagnosis , Citalopram/adverse effects , Citalopram/therapeutic use , Fibromyalgia/complications , Fatigue Syndrome, Chronic/complications , Fluoxetine/adverse effects , Fluoxetine/therapeutic use , Serotonin Uptake Inhibitors/adverse effects , Low Back Pain/complications , Cholinergic Antagonists/adverse effects , Medical Errors , Sertraline/adverse effects , Sertraline/therapeutic use , Depression/classification , Depression/complications , Depression/therapy , Depression/epidemiology , General Practice , Chronic Pain/complications , Venlafaxine Hydrochloride/adverse effects , Venlafaxine Hydrochloride/therapeutic use , Duloxetine Hydrochloride/adverse effects , Duloxetine Hydrochloride/therapeutic use , Serotonin and Noradrenaline Reuptake Inhibitors/adverse effects , Headache/complications , Amitriptyline/adverse effects , Amitriptyline/therapeutic use , Antidepressive Agents/administration & dosage
5.
Article in Chinese | WPRIM | ID: wpr-775922

ABSTRACT

OBJECTIVE@#To observe the effects of acupuncture on the fatigue symptoms of chronic fatigue syndrome, the potential symptoms and cytokines on the base of the theory as "interaction of brain and kidney" and explore its clinical therapeutic effects and the potential mechanism.@*METHODS@#A total of 68 patients were randomized into an observation group and a control group, 34 cases in each one. In the control group, oryzanol and vitamin B1 were prescribed for oral administration and the patients were required to have a proper rest and physical exercise. In the observation group, on the base of the theory as "interaction of brain and kidney", acupuncture was added to Baihui (BL 20), Fengchi (GB 20), Pishu (BL 20), Shenshu (BL 23), Sanyinjiao (SP 6) and Taixi (KI 3). The treatment was given once a day, 5 treatments a week, with 2 days break. The consecutive treatment for 4 weeks was required. Before and after treatment, the score of the fatigue scale-14 (FS-14), the score of the somatic and psychological health report (SPHERE) and the score of the Pittsburgh sleep quality index (PSQI) were observed in the patients of the two groups separately. The enzyme-linked immunosorbent assay (ELISA) was adopted to determine the levels of serum interleukin-6 (IL-6) and interferon-γ (INF-γ) before and after treatment.@*RESULTS@#After treatment, FS-14 scores, SPHERE scores and PSQI scores were all reduced as compared with the scores before treatment in the two groups (<0.05, <0.01). After treatment, the levels of IL-6 and INF-γ in the serum in the observation group were reduced as compared with the levels before treatment (both <0.01). After treatment, the scores of FS-14, SPHERE and PSQI as well as the levels of serum IL-6 and INF-γ in the observation group were all lower than the results in the control group (<0.05, <0.01).@*CONCLUSION@#On the base of the theory as "interaction of brain and kidney", acupuncture therapy relieves the fatigue symptoms and the potential symptoms and improves the sleep quality in the patients of chronic fatigue syndrome. The effect mechanism is probably related to the decrease of the levels of IL-6 and INF-γ in serum.


Subject(s)
Acupuncture Therapy , Brain , Fatigue Syndrome, Chronic , Therapeutics , Humans , Treatment Outcome
6.
Article in Chinese | WPRIM | ID: wpr-775921

ABSTRACT

OBJECTIVE@#To observe the clinical therapeutic effects of auricular gold-needle therapy on chronic fatigue syndrome of deficiency constitution and explore its potential mechanism.@*METHODS@#A total of 120 patients were randomized into an auricular gold-needle therapy group, an auricular point pressure therapy group and a Chinese herb group, 40 cases in each one. Additionally, a health control group (40 cases) was set up, without any intervention. In the auricular gold-needle therapy group, the gold needle was used to stimulate the auricular points on one side and the cowherb seed pressure therapy on the other side. In the auricular point pressure therapy group, the cowherb seed pressure therapy was adopted only on one side. The auricular points were shen (CO), xin (CO), fei (CO), pizhixia (AT), etc. in the two groups. The auricular points on both sides were used alternatively. The treatment was given once a week, 4 treatments as one course and the consecutive 3 courses of treatment were required. In the Chinese herb group, was prescribed for oral administration, 6 g, twice a day, the medication for 1 month was as one session and the consecutive 3 sessions of medication were required. Before and after treatment, separately, the clinical symptom score, the levels of the serum immunoglobulins, i.e. IgA, IgG and IgM were observed in the patients of the three groups. The therapeutic effects were evaluated in the three groups.@*RESULTS@#The total effective rate was 90.0% (36/40) in the auricular gold-needle therapy group, better than 80.0% (32/40) in the auricular point pressure therapy group and 82.5% (33/40) in the Chinese herb group (both <0.05). Before treatment, the clinical symptom scores of the patients in the three groups were obviously higher than the health control group (all <0.001). After treatment, the symptom scores were all reduced as compared the scores before treatment in the three groups (all <0.001) and the symptom scores in the auricular gold-needle therapy group were better than the auricular point pressure therapy group and the Chinese herb group (both <0.01). Before treatment, the levels of serum IgA, IgG and IgM of the patients in the three groups were lower than the health control group (all <0.001). The levels were all improved after treatment in the three groups (all <0.01), and the levels in the auricular gold-needle therapy group was better than the auricular point pressure therapy group and the Chinese herb group (all <0.05).@*CONCLUSION@#The auricular gold-needle therapy achieves the significant therapeutic effects on chronic fatigue syndrome of deficiency constitution and its mechanism is probably related to the regulation of immune function.


Subject(s)
Acupuncture Therapy , Fatigue Syndrome, Chronic , Gold , Humans , Qi , Treatment Outcome
7.
Article in English | WPRIM | ID: wpr-741916

ABSTRACT

OBJECTIVE: The present study compared cancer-related fatigue (CRF) and chronic fatigue syndrome (CFS) using multidimensional measurements with the aim of better understanding characteristics and exploring markers of two similar fatigue syndromes. METHODS: Twenty-five patients with CRF and twenty patients with CFS completed questionnaires, including the Fatigue Severity Scale (FSS), Hospital Anxiety Depression Scale (HADS), Perceived Stress Scale (PSS), and Pittsburgh Sleep Quality Index (PSQI). Additionally, levels of high sensitivity C-reactive protein (hs-CRP), heart rate variability (HRV), and electroencephalography (EEG) were obtained. Neurocognitive functioning was also evaluated. RESULTS: Both groups showed comparable levels of psychological variables, including fatigue. Compared to CFS subjects, CRF patients had significantly higher hs-CRP levels and a reduced HRV-index. The within-group analyses revealed that the FSS score of the CRF group was significantly related to scores on the HADS-anxiety, HADS-depression, and PSQI scales. In the CFS group, FSS scores were significantly associated with scores on the PSS and the absolute delta, theta, and alpha powers in frontal EEG. CONCLUSION: Findings indicate that different pathophysiological mechanisms underlie CFS and CRF. Inflammatory marker and HRV may be potential biomarkers for distinguishing two fatigue syndromes and frontal EEG parameters may be quantitative biomarkers for CFS.


Subject(s)
Anxiety , Biomarkers , C-Reactive Protein , Depression , Electrocardiography , Electroencephalography , Fatigue Syndrome, Chronic , Fatigue , Heart Rate , Humans , Weights and Measures
8.
Article in English | WPRIM | ID: wpr-714507

ABSTRACT

BACKGROUND: Recently, despite the high prevalence of fatigue in patients, there is a lack of research on the quality of life (QoL) in unexplained fatigue patients, indicating that they are not properly diagnosed and treated. The aim of this study was to compare fatigue severity and QoL between patients with explained and unexplained fatigue. METHODS: The study consisted of 200 Korean adults who complained of fatigue without underlying disease. Fatigue Severity Scale, Short Form Health Survey-36 version 2 (SF-36v2), and Beck Depression Inventory-II (BDI-II) self-questionnaires were administered. Participants were dichotomized to two groups, namely, patients with unexplained or explained fatigue, sorted according to laboratory examination results. The chi-square test, t-test, and Wilcoxon rank-sum test were used, and analysis of covariance was calculated after adjusting for age, sex, body mass index, smoking status, and physical component summary (PCS) of SF-36v2 or BDI-II. RESULTS: PCS of SF-36v2 between the two groups showed significant difference. Compared to patients with explained fatigue, those with unexplained fatigue showed lower physical component scores of QoL. CONCLUSION: QoL of patients with unexplained fatigue could largely diminish than those with explained fatigue. The primary clinician should be aware of poor QoL in patients with unexplained fatigue to identify who is in need of more attention and intervention.


Subject(s)
Adult , Body Mass Index , Depression , Fatigue Syndrome, Chronic , Fatigue , Humans , Prevalence , Primary Health Care , Quality of Life , Smoke , Smoking
9.
Chinese Journal of Applied Physiology ; (6): 340-344 349, 2018.
Article in Chinese | WPRIM | ID: wpr-773748

ABSTRACT

OBJECTIVE@#To study the differential metabolites in urine and the characteristics of metabolic pathway of middle school students with chronic fatigue syndrome (CFS) before and after exercise, and then explain the metabolic mechanism of CFS.@*METHODS@#Eight male middle school students (age:17-19) with CFS were selectedas the CFS group according to CFS screening criteria of the U.S. centers.At the same time, 8 male health students of the same age from the same school were selected as the control group. They were administrated to do one-time exercise on the improved Harvard step (up and down steps 30 times/min for 3minutes). Their urinewascollected before and after exercise, and the differential metabolitesin urine were detected by liquid chromatography-mass spectrometry (LC-MS). The multidimensional statistical methods were used to analyze the metabolites by principal component analysis (PCA) and orthogonal projections to latent structures-discriminant analysis (OPLS-DA). Finally, MetPA database was used to analyze the metabolites and to construct the correlativemetabolic pathways.@*RESULTS@#Compared with the control group, the creatine, indoleacetaldehyde, phytosphingosine and pyroglutamic acid were selected as differential metabolites and the contents of those were decreased significantly (<0.05 or <0.01) in CFS groupbefore the step movement. However, 11 differential metabolitesin CFS group were selected out after exercise, which were nonanedioic acid, methyladenosine, acetylcarnitine, capric acid, corticosterone, creatine, levonorgestrel, pantothenic acid, pyroglutamic acid, xanthosine and xanthurenic acid in sequence, the contents of methyladenosine and creatinewere significantly increased (<0.05) and the contents of the other 9 differentialmetabolites were significantly decreased (<0.05 or <0.01)compared with the control group.The 15 differential metabolites mentioned above were input MetPA database in order to analyze the metabolic pathways weighted score.The results showed that the arginine-proline metabolism pathway disordersweredetected in theCFS group before exercise, the marker metabolite wascreatine. And 3 metabolic pathwaysdisorder weredetectedin the CFS groupafter exercise, which were arginine-proline metabolism, biosynthesis of pantothenic acid and CoA, steroid hormone biosynthesis, and the marker metabolites, in turn, werecreatine, pantothenic acid and corticosterone.@*CONCLUSIONS@#The disorder of arginine-proline metabolic pathway is detected in CFS middle school students before exercise intervention. After exercise, it can be detected that the steroid hormone biosynthetic metabolic pathway, pantothenic acid and CoA metabolic pathways also have metabolic disorders.


Subject(s)
Adolescent , Biomarkers , Exercise , Fatigue Syndrome, Chronic , Humans , Male , Metabolomics , Students , Young Adult
10.
The Korean Journal of Pain ; : 147-154, 2018.
Article in English | WPRIM | ID: wpr-742192

ABSTRACT

Fibromyalgia (FM) is a contested illness with ill-defined boundaries. There is no clearly defined cut-point that separates FM from non-FM. Diagnosis of FM has been faced with several challenges that occur, including patients' health care-seeking behavior, symptoms recognition, and FM labeling by physicians. This review focuses on important but less visible factors that have a profound influence on under- or over-diagnosis of FM. FM shows different phenotypes and disease expression in patients and even in one patient over time. Psychosocial and cultural factors seem to be a contemporary ferment in FM which play a major role in physician diagnosis even more than having severe symptom levels in FM patients. Although the FM criteria are the only current methods which can be used for classification of FM patients in surveys, research, and clinical settings, there are several key pieces missing in the fibromyalgia diagnostic puzzle, such as invalidation, psychosocial factors, and heterogeneous disease expression. Regarding the complex nature of FM, as well as the arbitrary and illusory constructs of the existing FM criteria, FM diagnosis frequently fails to provide a clinical diagnosis fit to reality. A physicians' judgment, obtained in real communicative environments with patients, beyond the existing constructional scores, seems the only reliable way for more valid diagnoses. It plays a pivotal role in the meaning and conceptualization of symptoms and psychosocial factors, making diagnoses and labeling of FM. It is better to see FM as a whole, not as a medical specialty or constructional scores.


Subject(s)
Chronic Pain , Classification , Diagnosis , Dyssomnias , Fatigue Syndrome, Chronic , Fibromyalgia , Headache , Humans , Judgment , Musculoskeletal Diseases , Patient Selection , Phenotype , Psychology , Reproducibility of Results , Surveys and Questionnaires
11.
Med. leg. Costa Rica ; 34(2): 76-81, sep.-dic. 2017. tab
Article in Spanish | LILACS | ID: biblio-894323

ABSTRACT

ResumenEl síndrome de fatiga crónica es una patología que se caracteriza por fatiga intensa de como mínimo seis meses de duración, que se acompaña de otros síntomas y que en ocasiones podría ser tan intenso que causa la disminución de las actividades cotidianas del individuo que lo padece. El comienzo de los síntomas puede ser repentino o también de forma paulatina, muchas veces las personas recuerdan el momento en que comenzó y el principio de estos puede ser un cuadro similar a una gripe. A continuación, se hará una revisión bibliográfica sobre los principales aspectos de esta enfermedad, causa, criterios diagnósticos y tratamiento.


AbstractChronic fatigue syndrome is a pathology characterized by intense fatigue of at least six months duration, which is accompanied by other symptoms and which at times could be so intense that it causes the daily activities of the individual suffering from it to diminish. The onset of symptoms may be sudden or also gradually, many times people remember the time they started and the beginning of these can be a flu-like four. Next, a bibliographic review will be done on the main aspects of this disease, cause, diagnostic criteria and treatment.


Subject(s)
Humans , Physical Examination , Fatigue Syndrome, Chronic/diagnosis , Fatigue , Central Nervous System Sensitization
12.
Interface comun. saúde educ ; 20(56): 77-88, jan.-mar. 2016.
Article in Portuguese | LILACS | ID: lil-767966

ABSTRACT

Este artigo tem como objetivo explorar, do ponto de vista sociocultural, a emergência de duas entidades clínicas entre 1970 e 1980 que, no campo da clínica geral e dos saberes psi, nomeiam quadros centrados no sintoma da fadiga: a síndrome da fadiga crônica (CID-10 G93.3) e o burnout (CID-10 Z73.0). Pretendemos, após uma breve apresentação de ambas, analisar o surgimento dessas categorias, para indicar o cansaço e a exaustão como sintomas a serem tratados medicamente e explorar os pontos de aproximação e afastamento entre elas...


The objective of this article was, from a sociocultural perspective, to explore the emergence of two clinical entities between 1970 and 1980, which, in the fields of general clinical medicine and psycho-knowledge, give names to conditions centered on the symptom of fatigue: chronic fatigue syndrome (ICD-10 G93.3) and burnout (ICD-10 Z73.0). We intend, after a brief presentation of both of these, to analyze the emergence of these two categories, to acknowledge fatigue and exhaustion as symptoms to be medically treated, and to explore similarities and differences between them...


El objetivo de este artículo es explorar, desde el punto de vista sociocultural, la emergencia de dos entidades clínicas entre 1970 y 1980 que, en el campo de la clínica general y de los saberes psi, dan nombre a cuadros centrados en el síntoma de la fatiga: el síndrome de la fatiga crónica (CID-10 G93.3) y el burnout (CID-10 Z73.0). Pretendemos, después de una breve presentación de ambas, analizar el surgimiento de esas categorías, para indicar el cansancio y el agotamiento como síntomas que hay que tratar médicamente y explorar los puntos de aproximación y de separación entre ellas...


Subject(s)
Humans , Burnout, Professional , Fatigue Syndrome, Chronic , Sociology, Medical
13.
Clinical Endoscopy ; : 257-265, 2016.
Article in English | WPRIM | ID: wpr-175026

ABSTRACT

Fecal microbiota transplantation (FMT) is the infusion of liquid filtrate feces from a healthy donor into the gut of a recipient to cure a specific disease. A fecal suspension can be administered by nasogastric or nasoduodenal tube, colonoscope, enema, or capsule. The high success rate and safety in the short term reported for recurrent Clostridium difficile infection has elevated FMT as an emerging treatment for a wide range of disorders, including Parkinson's disease, fibromyalgia, chronic fatigue syndrome, myoclonus dystopia, multiple sclerosis, obesity, insulin resistance, metabolic syndrome, and autism. There are many unanswered questions regarding FMT, including donor selection and screening, standardized protocols, long-term safety, and regulatory issues. This article reviews the efficacy and safety of FMT used in treating a variety of diseases, methodology, criteria for donor selection and screening, and various concerns regarding FMT.


Subject(s)
Autistic Disorder , Clostridioides difficile , Colitis, Ulcerative , Colonoscopes , Crohn Disease , Donor Selection , Enema , Fatigue Syndrome, Chronic , Fecal Microbiota Transplantation , Feces , Fibromyalgia , Humans , Insulin Resistance , Irritable Bowel Syndrome , Mass Screening , Multiple Sclerosis , Myoclonus , Obesity , Parkinson Disease , Tissue Donors
14.
Article in English | WPRIM | ID: wpr-108201

ABSTRACT

Fecal microbiota transplantation has a 1700-year history. This forgotten treatment method has been put into use again during the last 50 years. The interest in microbiota-gut-brain axis and fecal microbiota transplantation is rapidly increasing. New evidence is obtained in the etiopathogenesis of neuropsychiatric disorders. There is a large number of experimental and clinical researches in the field of gut-brain axis. There is limited information on fecal microbiota transplantation. Despite this, initial results are promising. It is commonly used in the treatment of gastrointestinal diseases such as Clostridium difficile infection, Crohn's disease, ulcerative colitis. It is also experimentally used in the treatment of metabolic and autoimmune diseases. There are case reports that it is effective in the treatment of autism, Parkinson's disease, multiple sclerosis, chronic fatigue syndrome and irritable bowel syndrome. Its implementation is easy, and it is a cheap and reliable treatment method. However, the long-term risks are unknown. Additionally, standard application protocols have not yet been established. There are a lot of questions to be answered. A university in Turkey has got official permission this year, and started to apply fecal microbiota transplantation. In this review, neuropsychiatric areas of use of fecal microbiota transplantation have been discussed in the light of the current information.


Subject(s)
Autistic Disorder , Autoimmune Diseases , Clostridioides difficile , Colitis, Ulcerative , Crohn Disease , Fatigue Syndrome, Chronic , Fecal Microbiota Transplantation , Gastrointestinal Diseases , Immune System , Irritable Bowel Syndrome , Methods , Multiple Sclerosis , Neurology , Parkinson Disease , Turkey
15.
Rev. colomb. reumatol ; 23(1): 3-10, enero-marzo.2016. tab
Article in Spanish | LILACS | ID: biblio-836078

ABSTRACT

(au)Introducción: La fibromialgia es una enfermedad crónica, caracterizada por dolor musculoesqueléticoasociado a otros síntomas. Se desconoce su etiología, el diagnóstico es clínico ylos tratamientos sintomáticos. El cómo afrontan los pacientes este dolor y su diagnósticoparece influir sobre su evolución y tratamiento.Objetivo: Evaluar el efecto de la catastrofización y ansiedad ante el dolor, sobre la capacidadfuncional y el consumo de fármacos de los pacientes con fibromialgia.Materiales y métodos: Estudio transversal de 50 pacientes con fibromialgia, citados en reumatologíadesde el 1 de enero hasta el 31 de marzo de 2014 y voluntarios de la Asociaciónde Enfermos de Fibromialgia de Asturias. Se registraron variables clínico-epidemiológicas,Cuestionario de Impacto de la Fibromialgia abreviado (CIF), Escala de Catastrofización Anteel Dolor (PCS-SP) y Escala de Síntomas de Ansiedad Ante el Dolor (PASS-20).Resultados: La correlación de Spearman entre PCS-SP y PASS-20 fue de 0,67 (p < 0,001), entreCIF y PASS-20 de 0,27 (p = 0,05) y entre CIF y PCS-SP de 0,03, sin significación estadística.La correlación con el consumo de fármacos fue: con PASS-20 0,41 (p = 0,003), con PCS-SP0,49 (p < 0,001) y con CIF 0,32 (p = 0,024). El coeficiente de correlación desde el inicio de lossíntomas fue: −0,21 (p = 0,14) con CIF, −0,16 (p = 0,26) con PCS y −0,25 (p = 0,08) con PASS-20.Conclusiones: Los niveles de ansiedad y catastrofización se encuentran fuertemente asociadosentre sí, sin embargo, ambos muestran una asociación débil con la capacidad funcional.Puntuaciones altas en las 3 escalas supusieron un aumento del consumo de fármacos. Conmayor tiempo de evolución de la fibromialgia parece disminuir el nivel de ansiedad, lacatastrofización y la repercusión funcional.


Subject(s)
Humans , Anxiety , Catastrophization , Fibromyalgia , Pain Management , Fatigue Syndrome, Chronic
16.
Biol. Res ; 49: 1-8, 2016. graf
Article in English | LILACS | ID: biblio-950854

ABSTRACT

BACKGROUND: Transient receptor potential melastatin 3 (TRPM3) cation channels are ubiquitously expressed by multiple cells and have an important regulatory role in calcium-dependent cell signalling to help maintain cellular homeostasis. TRPM3 protein expression has yet to be determined on Natural Killer (NK) cells and B lymphocytes. Multiple single nucleotide polymorphisms have been reported in TRPM3 genes from isolated peripheral blood mononuclear cells, NK and B cells in Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) patients and have been proposed to correlate with illness presentation. The object of the study was to assess TRPM3 surface expression on NK and B lymphocytes from healthy controls, followed by a comparative investigation examining TRPM3 surface expression, and cytoplasmic and mitochondrial calcium influx in CD19+ B cells, CD56bnght and CD56dim cell populations from CFS/ME patients. RESULTS: TRPM3 cell surface expression was identified for NK and B lymphocytes in healthy controls (CD56bright TRPM3 35.72 % ± 7.37; CD56dim 5.74 % ± 2.00; B lymphocytes 2.05 % ± 0.19, respectively). There was a significant reduction of TRPM3 surface expression on CD19+ B cells (1.56 ± 0.191) and CD56bright NK cells (17.37 % ± 5.34) in CFS/ME compared with healthy controls. Anti-CD21 and anti-IgM conjugated biotin was cross-linked with streptavidin,and subsequently treatment with thapsigargin. This showed a significant reduction in cytoplasmic calcium ion concentration in CD19+ B lymphocytes. CD56bright NK cells also had a significant decrease in cytoplasmic calcium in the presence of 2-APB and thapsigargin in CFS/ME patients. CONCLUSIONS: The results from this preliminary investigation identify, for the first time, TRPM3 surface expression on both NK and B lymphocytes in healthy controls. We also report for the first time, significant reduction in TRPM3 cell surface expression in NK and B lymphocytes, as well as decreased intracellular calcium within specific conditions in CFS/ME patients. This warrants further examination of these pathways to elucidate whether TRPM3 and impaired calcium mobilisation has a role in CFS/ME.


Subject(s)
Humans , Male , Female , Middle Aged , B-Lymphocytes/metabolism , Killer Cells, Natural/metabolism , Fatigue Syndrome, Chronic/blood , TRPM Cation Channels/metabolism , Reference Values , Calcium Channels/blood , Case-Control Studies , Fatigue Syndrome, Chronic/drug therapy , Analysis of Variance , Immunophenotyping/methods , Thapsigargin/therapeutic use , Enzyme Inhibitors/therapeutic use , Flow Cytometry/methods
18.
Chinese Acupuncture & Moxibustion ; (12): 1127-1130, 2015.
Article in Chinese | WPRIM | ID: wpr-269784

ABSTRACT

<p><b>OBJECTIVE</b>To observe the clinical effect of chronic fatigue syndrome (CFS) treated with moxibustion at Gaohuang (BL 43).</p><p><b>METHODS</b>With stratified block randomization, 72 patients accorded with inclusive criteria were divided into a moxibustion at Gaohuang (BL 43) group (moxibustion group) and an acupuncture group, 36 cases in each one. In the moxibustion group, Gaohuang (BL 43) was treated with big moxa cones as the main acupoint, 10 cones a time; Qihai (CV 6) and Zusanli (ST 36) were added with big moxa cones, 7 cones a time. In the acupuncture group, acupoints were the same as those in the moxibustion group, and twirling reinforcing method was used after qi arriving, 60 times one minute and 360° with range. In the two groups, 10-day treatment was made into one course and there were two days between courses. The treatment was given once a day for 3 courses. Changes of fatigue assessment index (FAI) before and after treatment and clinical effects were observed.</p><p><b>RESULTS</b>The total effective rate was 88.9% (32/36) in the moxibustion group, which was better than 72.2% (26/36) in the acupuncture group apparently (P < 0.05). After treatment in the two groups, FAI scores were obviously declined compared with those before treatment (both P < 0.01) and FAI score in the moxibustion group was apparently lower than that in the acupuncture group (P < 0.05).</p><p><b>CONCLUSION</b>Moxibustion at Gaohuang (BL 43) can improve the FAI score of patients with CFS and the clinical efficacy is definite.</p>


Subject(s)
Acupuncture Points , Adult , Fatigue Syndrome, Chronic , Therapeutics , Female , Humans , Male , Middle Aged , Moxibustion , Treatment Outcome , Young Adult
19.
Article in Chinese | WPRIM | ID: wpr-360298

ABSTRACT

The bladder meridian of foot-taiyang is considered as key of six meridians and the yang of the yang, which is the pivot of transportation for qi and blood in the meridians and zang-fu. The running route and treatment characteristic of bladder meridian is closely related with chronic fatigue syndrome (CFS). The bladder meridian belongs to brain and connects with governor vessel, which has a close relationship with zang-fu function, quality of sleep and fatigue. Besides, the running route of bladder meridian is highly consistent with the surface projections of important anatomical structures such as muscle, nerve and sympathetic trunk, etc. Therefore, regulating the meridian-qi of bladder meridian can harmonize five-zang and calm the mind, but also effectively relieve physical and mental fatigue in CFS.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Fatigue Syndrome, Chronic , Therapeutics , Humans , Meridians
20.
J. bras. med ; 102(1)jan.-fev. 2014.
Article in Portuguese | LILACS | ID: lil-712208

ABSTRACT

A síndrome de fadiga crônica (SFC) é uma condição clínica que, apesar de muito prevalente, tem tratamento controverso. A suplementação com substratos como glutamina e vitaminas pode atuar como adjuvante terapêutico. Os autores descrevem um medicamento que pode atender essa finalidade, composto por glutamina 200mg, glutamato de cálcio 250mg, cloridrato de piridoxina 20mg e fosfato de ditetraetilamônio 6mg. São descritas também as ações de cada um dos componentes, e como podem auxiliar na terapêutica da SFC e em períodos de convalescença em diversas condições.


The chronic fatigue syndrome (CFS) is a clinical condition which, although highly prevalent, treatment is controversial and supplementation of substrates such as glutamine and vitamins can act as therapeutic adjuvant. A drug composition that can serve this purpose, the composition is glutamine 200mg, 250mg calcium glutamate, 20mg pyridoxine hydrochloride and phosphate ditetraetilammonium 6mg is described. Also described the actions of each component and how they can assist in the treatment of CFS and in periods of convalescence from various other conditions described.


Subject(s)
Humans , Male , Female , Fatigue Syndrome, Chronic/diet therapy , Fatigue Syndrome, Chronic/therapy , Convalescence , Dietary Vitamins , Glutamates/therapeutic use , Glutamine/therapeutic use , Minerals/therapeutic use , Pyridoxine/therapeutic use , Dietary Supplements , Tetraethylammonium/therapeutic use
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