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1.
Esc. Anna Nery Rev. Enferm ; 26: e20210203, 2022. tab
Article in Portuguese | LILACS, BDENF | ID: biblio-1356215

ABSTRACT

RESUMO Objetivo analisar as características individuais, clínicas e os fatores associados à mortalidade de pacientes com COVID-19, em hospital público do estado do Paraná, Brasil. Métodos estudo seccional, retrospectivo, documental (n= 86), com pacientes adultos internados, de março a junho de 2020. Resultados a mortalidade foi de 12,8%, o grupo de maior risco foi de idosos com comorbidades, especialmente, cardiovasculares. A chance de óbito foi 58 vezes maior em idosos, comparada aos adultos, e oito vezes maior naqueles com comorbidades, comparadas aos hígidos. A maioria dos pacientes apresentou sintomatologia respiratória, febre e mialgia. Tratamento à base de antibióticos, anticoagulantes e antivirais, associado ao suporte ventilatório. As principais complicações foram hipóxia, insuficiência renal aguda e infecção secundária. Conclusão e implicações para a prática idosos com comorbidades cardiovasculares que necessitaram de cuidados intensivos apresentaram maior chance de óbito. Os resultados de um dos centros de referência na pandemia possibilitam discutir medidas epidemiológicas adotadas, com ênfase em conceitos restritivos nos primeiros meses.


RESUMEN Objetivo analizar las características individuales, clínicas y los factores asociados a la mortalidad en pacientes con COVID-19 en un hospital público del estado de Paraná. Métodos estudio transversal, retrospectivo, documental (n = 86), con pacientes adultos hospitalizados, de marzo a junio de 2020. Resultados la mortalidad fue del 12,8%, grupo de mayor riesgo para los ancianos con comorbilidades, especialmente enfermedades cardiovasculares. La probabilidad de muerte fue 58 veces mayor en los ancianos en comparación con los adultos y ocho veces mayor en aquellos con comorbilidades en comparación con los sanos. La mayoría de los pacientes presentaban síntomas respiratorios, fiebre y mialgia. Tratamiento a base de antibióticos, anticoagulantes y antivirales, asociado al soporte ventilatorio. Las principales complicaciones fueron hipoxia, insuficiencia renal aguda e infección secundaria. Conclusión e implicaciones para la práctica los ancianos con comorbilidades cardiovasculares que requirieron cuidados intensivos tenían una mayor probabilidad de muerte. Los resultados de uno de los centros de referencia pandémica permiten discutir las medidas epidemiológicas adoptadas, con énfasis en conceptos restrictivos en los primeros meses.


ABSTRACT Objective to analyze the individual and clinical characteristics and the factors associated with mortality in patients with COVID-19, in a public hospital in the state of Paraná, Brazil. Methods a cross-sectional, retrospective, documentary study (n= 86), with adult inpatients, from March to June 2020. Results mortality was 12.8%, the highest risk group was the elderly with comorbidities, especially cardiovascular ones. The chance of death was 58 times higher in the elderly compared to adults, and eight times higher in those with comorbidities compared to the healthy ones. Most patients presented with respiratory symptoms, fever, and myalgia. Treatment was based on antibiotics, anticoagulants and antivirals, associated with ventilatory support. The main complications were hypoxia, acute renal failure, and secondary infection. Conclusion and implications for practice elderly people with cardiovascular comorbidities who required intensive care had a higher chance of death. The results from one of the reference centers in the pandemic make it possible to discuss epidemiological measures adopted, with emphasis on restrictive concepts in the first months.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Health Profile , COVID-19/mortality , Antiviral Agents/therapeutic use , Patients' Rooms , Brazil , Comorbidity , Retrospective Studies , Risk Factors , Azithromycin/therapeutic use , Cough , Dyspnea , Renal Insufficiency/complications , Fever , Interactive Ventilatory Support , Myalgia , COVID-19/therapy , Inpatients/statistics & numerical data , Intensive Care Units , Length of Stay/statistics & numerical data , Hypoxia/complications , Anticoagulants/therapeutic use
2.
repert. med. cir ; 31(1): 79-83, 2022. tab.
Article in English, Spanish | LILACS, COLNAL | ID: biblio-1367068

ABSTRACT

Introducción: Constantin von Economo reportó en 1917 múltiples casos de manifestaciones neurológicas secundarias a la pandemia de la gripe española, clasificándolos en tres grandes grupos: forma somnolienta-oftalmopléjica, mutismo y la hipercinética, con secuelas similares a la enfermedad de Parkinson. Objetivo: presentar un caso de reciente aparición de patología rara en Cali, Colombia con manejo adecuado en unidad de cuidados intensivos (UCI). Presentación del caso: paciente de 9 años con disminución de la fuerza en extremidades, disartria y somnolencia, que inició deterioro neurológico progresivo requiriendo manejo en UCI. El equipo multidisciplinario diagnosticó encefalitis letárgica e iniciaron manejo con plasmaféresis e inmunosupresión con mejoría significativa. Discusión y conclusiones: como la prevalencia es escasa, el diagnóstico exige un alto índice de sospecha como la ocurrencia de un cuadro infeccioso previo al inicio de los síntomas, ya que se considera una reacción autoinmune cruzada contra antígenos de la sustancia nigra. En algunos casos hay alteraciones en los estudios imagenológicos o en citoquímico de líquido cefalorraquídeo. El manejo con pulsos de metilprednisolona y filtración de plasma con plasmaféresis brinda mejoría significativa con disminución de las secuelas a futuro.


Introduction: In 1917, Constantin von Economo reported multiple cases of neurological manifestations secondary to the Spanish flu pandemic. He classified them into three main clinical forms: somnolent-ophthalmoplegic, mutism and hyperkinetic, causing sequelae resembling Parkinson ́s disease. Objective: to present a case of a recent appearance rare disease entity, in Cali Colombia, receiving appropriate management in the Intensive Care Unit (ICU). Case presentation: 9-year-old patient presenting with limb muscle weakness, dysarthria and somnolence, evidencing progressive neurological deterioration requiring admission to the ICU for management. A diagnosis of encephalitis lethargica (EL) was made by the attending multidisciplinary team and management with plasmapheresis and immunosuppression was started, obtaining significant improvement. Discussion and conclusions: as the prevalence is low, the diagnosis requires a high level of suspicion in cases presenting with infectious conditions prior to the development of symptoms, since it is considered an autoimmune cross-reaction against substantia nigra antigens. Alterations in brain imaging or in cerebrospinal fluid cytometry may be found in some cases. Management with methylprednisolone pulse therapy and filtration plasmapheresis provides significant improvement with a decrease in future sequelae.


Subject(s)
Humans , Female , Child , Parkinson Disease, Postencephalitic , Encephalitis, St. Louis , Fever , Autoimmunity , Influenza, Human
3.
Article in Portuguese | LILACS | ID: biblio-1353104

ABSTRACT

A esquistossomose é uma endemia parasitária típica das Américas, Ásia e África. A Mielorradiculopatia Esquistossomótica surge como uma evolução severa da infecção por esquistossomose e, apesar de muito comum, sua prevalência em áreas endêmicas vem sendo subestimada. Objetivo: relatar caso de Mielorradiculopatia Esquistossomótica ocorrido em paciente pediátrico. Metodologia: estudo descritivo do tipo Relato de Caso retrospectivo, submetido e aprovado pelo Comitê de Ética em Pesquisa do Centro Universitário CESMAC, CAAE: 28835220.0.0000.0039, N.º do Parecer: 3.898.292. Relato de caso: paciente do sexo masculino, previamente hígido, 11 anos, iniciou quadro com história álgica aguda em membros inferiores que piorava no período da noite acompanhada de relato de febre. Quadro clínico evoluiu com lombalgia, disúria, oligúria, posterior anúria e formação de globo vesical. Evoluiu, também, com paresia de membros inferiores. A investigação realizou-se com Exame Parasitológico de Fezes positivo para esquistossomose, além de Ressonância Magnética de coluna lombo-sacra que corroboraram com a hipótese diagnóstica. Instituiu-se tratamento com Albendazol, Praziquantel e pulsoterapia com Metilprednisolona durante internação. Paciente teve alta hospitalar com melhora de quadro neurológico, em uso de prednisona 40 mg/dia. Conclusão: a MRE constitui a forma mais grave dentre as manifestações ectópicas da esquistossomose. A dificuldade do reconhecimento do quadro clínico e a limitação no acesso aos métodos complementares diagnósticos contribuem para o subdiagnóstico da enfermidade, acarretando sequelas graves para os portadores da doença e ocultando sua importância epidemiológica principalmente em pacientes pediátricos e jovens. (AU)


Schistosomiasis is a parasitic endemic typical of the Americas, Asia and Africa. Schistosomal Myeloradiculopathy is a severe evolution of schistosomiasis infection and, although very common, the prevalence in endemic areas has been underestimated. Objective: to report Schistosomal Myeloradiculopathy case in a pediatric patient. Methodology: descriptive study of the type Case Report retrospective, submitted and approved by the Research Ethics Committee of the CESMAC University Center, CAAE: 28835220.0.0000.0039, Opinion N.º: 3.898.292. Case report: a previously healthy 11-year-old boy, started with a history of acute pain in lower limbs that worsened during the night accompanied of fever. Evolved with low back pain, dysuria, oliguria, subsequent anuria, vesical globe formation and lower limbs paresis. The investigation resulted in positive stool examination for schistosomiasis and magnetic resonance imaging of lumbosacral spine that corroborated the diagnostic hypothesis. The treatment included Albendazol, Praziquantel and pulsetherapy with Methylprednisolone during hospitalization. The patient was discharged from the hospital with improved neurological status, using prednisone 40 mg/day. Conclusion: Schistosomal Myeloradiculopathy is the most severe form of the ectopic manifestations of schistosomiasis. The difficulty in recognizing the clinical condition and the limitation of access to complementary diagnostic methods contributes to the underdiagnosis of the disease, causing severe sequels for patients with disease and hiding its epidemiological importance, especially in pediatric and young patients. (AU)


Subject(s)
Humans , Male , Child , Oliguria , Paresis , Methylprednisolone , Prednisone , Endemic Diseases , Neuroschistosomiasis , Neglected Diseases , Fever
4.
Rev. cuba. pediatr ; 93(3): e1480, 2021. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1347533

ABSTRACT

Introducción: La población infantil presenta una escasa morbilidad y mortalidad por COVID-19; sin embargo, los niños infectados por el SARS-CoV-2 están en aumento y cabe la necesidad de caracterizarlos según sus diversas variables de presentación. Objetivo: Examinar las características sociales, clínicas, condiciones epidemiológicas y cuadro clínico de los niños diagnosticados con COVID-19. Métodos: Estudio descriptivo retrospectivo, con muestra de 88 niños menores de 12 años. Se revisó la base de datos de la oficina de epidemiología del hospital autorizado para el registro de casos confirmados de COVID-19 en la provincia de Chota, Perú. Se obtuvo la autorización de la dirección de la institución para utilizar la data exclusivamente con fines investigativos. El periodo de análisis: 14 de abril (caso cero en la provincia) de 2020-28 de enero de 2021. Resultados: En la muestra 51,1 por ciento fueron mujeres, el promedio de edad 5,6 años; 10,2 por ciento estuvo hospitalizado, 83 por ciento fue puesto en aislamiento, y 98,9 por ciento presentó una recuperación satisfactoria. Las manifestaciones fundamentales en los niños fueron: tos 26,1 por ciento; fiebre 23,9 por ciento y cefalea 19,3 por ciento. Las condiciones epidemiológicas detectadas fueron: 1,4 por ciento viajó en las últimas dos semanas; 47,7 por ciento tuvo contagio intradomiciliario y 67 por ciento asintomático. No se informaron niños fallecidos, intubados, ventilados o con neumonía. Conclusiones: Los niños son igual de susceptibles a la COVID-19 que otras personas; presentan cuadros clínicos menos graves que cursan principalmente con tos, fiebre, cefalea y malestar general; muestran una evolución más favorable y altas prevalencias de asintomáticos y contagios intradomiciliarios(AU)


Introduction: Children population has low morbidity and mortality by COVID-19; however, children infected with SARS-CoV-2 are on the rise and may need to be characterized according to their various presentation variables. Objective: Examine the social, clinical characteristics, epidemiological conditions and clinical picture of children diagnosed with COVID-19. Methods: Retrospective descriptive study, with a sample of 88 children under 12 years old. The database of the hospital´s epidemiology office authorized for the registration of confirmed cases of COVID-19 in Chota province, Peru, was reviewed. Authorization was obtained from the institution's management to use the data exclusively for research purposes. The analysis period was from April 14, 2020 (zero case in the province) to January 28, 2021. Results: In the sample 51.1 percent were women, the average age was 5.6 years; 10.2 percent were hospitalized, 83 percent were put in isolation, and 98.9 percent had a satisfactory recovery. The main manifestations in children were: cough, 26.1 percent; fever, 23.9 percent and headache, 19.3 percent. Epidemiological conditions detected were: 1.4 percent traveled in the last two weeks; 47.7 percent had intradomyciliary contagion, and 67 percent were asymptomatic. No children were reported deceased, intubated, ventilated or with pneumonia. Conclusions: Children are just as susceptible to COVID-19 as other people; they have less severe clinical pictures that occur mainly with cough, fever, headache and general discomfort; they show a more favorable evolution and high prevalence of asymptomatic and intradomyciliary contagions(AU)


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Fever/etiology , SARS-CoV-2 , COVID-19/epidemiology , Headache/etiology , Peru , Epidemiology, Descriptive , Retrospective Studies
6.
Rev. med. Risaralda ; 27(1): 96-100, ene.-jun. 2021. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1280499

ABSTRACT

Resumen El síndrome de DRESS (Reacción a drogas con eosinofilia y síntomas sistémicos) es una patología poco frecuente en Pediatría, descrita por primera vez en 1996, por Bocquet. Puede presentarse en un tiempo variable luego de exposición a algunos medicamentos, se caracteriza por fiebre, compromiso cutáneo y de órganos internos. En este caso, se presenta a un paciente de 13 años, con antecedente de uso de Trimetroprim sulfa desde hace 2 meses, con cuadro de 3 días consistente en fiebre y rash cutáneo, sin compromiso de mucosas, con respuesta no favorable al manejo con esteroide, requiriendo Inmunoglobulina IV. Semanas después del inicio de los síntomas y evolución estable presenta insuficiencia renal aguda que requirió terapia de reemplazo renal. Se descartaron otras patologías subyacentes de índole autoinmune. Hubo recuperación de azoados y normalización de los demás paraclínicos el día 40 de la enfermedad. El paciente continúa asintomático, 4 meses después, con tratamiento con esteroide oral, en descenso lento y gradual. Se debe considerar la evaluación permanente de las pruebas de función renal en los pacientes que presenten Síndrome de DRESS, por su asociación con Nefritis intersticial aguda y complicaciones relacionadas.


Abstract DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a rare pathology in Pediatrics, first described in 1996 by Bocquet. It can appear in a variable period of time after exposure to some medications, it is characterized by fever, skin involvement and internal organs. A 13-year-old patient is presented, with a history of use of Trimethoprim sulfa for two months, with a disease of three days of evolution, consisting of fever and skin rash, without mucosal involvement, with an unfavorable response to steroid management, requiring Intravenous inmunoglobulin. Weeks after the onset of symptoms and stable evolution, he presented acute renal failure that required renal replacement therapy. Other underlying autoimmune pathologies were ruled out. There was recovery of renal function test and normalization of the other paraclinical on day 40 of the disease. Patient remains asymptomatic four months later, with oral steroid treatment, in slow and gradual decline. Permanent evaluation of renal function tests should be considered in patients with DRESS syndrome, due to its association with acute tubulointerstitial nephritis and related complications.


Subject(s)
Humans , Male , Adolescent , Eosinophilia , Renal Insufficiency , Drug Hypersensitivity Syndrome , Kidney Function Tests , Nephritis, Interstitial , Steroids , Trimethoprim , Immunoglobulins , Pharmaceutical Preparations , Renal Replacement Therapy , Exanthema , Fever
7.
Rev. med. Risaralda ; 27(1): 10-20, ene.-jun. 2021. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1280488

ABSTRACT

Resumen Objetivo: Describir la epidemiología de la Leptospirosis en el departamento del Huila durante el período 2011 -2017. Materiales y métodos: Estudio descriptivo de corte transversal, retrospectivo. La población analizada fueron pacientes de los diferentes municipios del departamento del Huila que se reportaron como casos probables o confirmados de leptospirosis. Se estructuraron registros por cada año en bases de datos recopiladas por el área de epidemiología de la Secretaría de Salud del Huila, basadas en las fichas de notificación de vigilancia en salud pública para leptospirosis y generadas por cada Unidad Primaria Generadora de Datos (UPGD) ante la presencia del evento. Los datos fueron discriminados de acuerdo a las variables de interés para el estudio en una nueva base de datos en Excel; tabuladas con el programa estadístico R - Studio 3.3.3 y Epidat 4.2, para luego ser procesados con estadísticos descriptivos y finalmente ser expresados en porcentajes y en tasas de incidencia. Resultados: Se reportaron 268 casos, de los cuales 61 (23%) fueron confirmados por laboratorio y 207 (77%) sospechosos o probables. El 69% de los pacientes presentaron fiebre, mialgias y cefalea como síntomas representativos. El grupo etario más afectado tenía entre 27 y 59 años de edad (44%). La población se caracterizó por ser del área urbana (65%), con mayor frecuencia en hombres (72%). En relación a la ocupación laboral, se encontró mayor frecuencia en agricultores (20%) y en el personal de aseo (17%). Los factores de riesgo evidenciados fueron la presencia de animales domésticos en un 67% de los casos, así como la presencia de ratas en el hogar (51%) y el posible mal manejo del agua. Conclusiones: El incremento en el número de casos de Leptospirosis probablemente está asociado a la mala manipulación del agua y a la presencia de animales en el domicilio.


Abstract Objective: Describe the epidemiology of Leptospirosis in the department of Huila during the years 2011 to 2017. Materials and methods: This article is a descriptive, cross-sectional, retrospective study. The population analyzed were patients from the different municipalities of the department of Huila who were reported as probable or confirmed cases for leptospirosis, structuring records for each year in databases compiled by the epidemiology area of ​​the department's health secretary, based on the public health surveillance notification sheets for leptospirosis, and generated by each Primary Data Generating Unit (UPGD) in the presence of the event; The data were discriminated according to the variables of interest for the study in a new database in Excel; tabulated with the statistical program R - Studio 3.3.3 and Epidat 4.2, to later be processed with descriptive statistics and finally expressed in percentages and incidence rates. Results: 268 cases were reported, which 61 (23%) were confirmed by laboratory and 207 (77%) suspicious or probable. 69% of the patients presented fever, myalgia and headache as representative symptoms. The most affected group range in ages from 27 and 59 (44%). The population was characterized for being part of the urban area (65%), and the cases were more frequent in men (72%). Regarding to employment, it was found that farmers (20%) and the cleaning staff (17%) were the most common cases. The risk factors identified were the presence of domestic animals in 67% of the cases, as well as the presence of rats at home (51%) and the possible poor water management. Conclusions: The increase in the number of cases of Leptospirosis is probably associated with the poor water management and the presence of animals at home.


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Aged , Zoonoses , Risk Factors , Myalgia , Leptospirosis/epidemiology , Retrospective Studies , Colombia , Fever , Public Health Surveillance , Farmers , Headache , Animals, Domestic
8.
An. bras. dermatol ; 96(3): 319-323, May-June 2021. graf
Article in English | LILACS | ID: biblio-1285068

ABSTRACT

Abstract Sweet syndrome is an inflammatory disease characterized by fever, neutrophilia, papules and erythematous plaques, and a skin neutrophilic infiltrate. Syphilis has been reported among the infectious causes of Sweet syndrome. Syphilis can present atypical manifestations; a rare presentation is nodular syphilis, characterized by nodules with granulomas and plasma cells at histopathology. This case report presents a 20-year-old woman patient, with plaques and nodules, and systemic symptoms. The histopathological exam revealed both non-tuberculoid granulomas and a dense infiltration of polymorphonuclear neutrophils in the dermis. These findings, plus laboratory abnormalities, characteristic of both conditions, were conclusive for Sweet syndrome and nodular syphilis association.


Subject(s)
Humans , Female , Adult , Young Adult , Syphilis , Sweet Syndrome/complications , Sweet Syndrome/diagnosis , Skin , Fever , Granuloma
9.
Biomédica (Bogotá) ; 41(2): 208-217, abr.-jun. 2021. tab, graf
Article in Spanish | LILACS | ID: biblio-1339259

ABSTRACT

Resumen. Se presenta el caso de un hombre de 50 años de edad proveniente de la región de Urabá, Colombia, con una infección mixta por Rickettsia rickettsii y Leptospira interrogans serovar Copenhageni ST78, y pruebas negativas para malaria y dengue. El paciente presentó un síndrome febril que no mejoró con el tratamiento antibiótico sistémico y, finalmente, falleció en la unidad de cuidados intensivos. El diagnóstico post mortem se hizo mediante tipificación molecular de los dos agentes etiológicos. En la inspección del domicilio del paciente, se encontró un ejemplar de Rattus rattus infectado con L. interrogans del mismo serovar detectado en él. No se encontraron garrapatas en los animales domésticos que habitaban con el paciente. Se reporta una infección mixta con síntomas clínicos progresivos y fatales en un paciente con antecedentes laborales de riesgo en una zona endémica para enfermedades tropicales, lo que obliga a tener presente la posibilidad de infecciones simultáneas en personas procedentes de áreas endémicas que consulten reiteradamente por síndrome febril sin resolución y tengan riesgo laboral relacionado con actividades agrícolas.


Abstract. This is the case of a 50-year-old male from the region of Urabá, Colombia, with a mixed infection by Rickettsia rickettsii and Leptospira interrogans serovar Copenhageni ST78 and negative test for malaria and dengue fever. The patient presented with febrile syndrome and was unresponsive to systemic antibiotic treatment, who finally died in the intensive care unit. We established the postmortem diagnosis through molecular typification of the two etiological agents. In the inspection at the patient's home, we found a Rattus rattus specimen infected with L. interrogans of the same serovar found in him. We found no ticks parasitizing the domestic animals cohabitating with the patient. This case of a mixed infection with progressive and fatal symptoms in a patient with occupational risk in a tropical disease endemic zone highlights the importance of considering the potential presentation of simultaneous etiologies in patients with multiple medical visits for unresolved febrile syndromes associated with risky exposure during agricultural activities.


Subject(s)
Rickettsiaceae Infections/diagnosis , Leptospirosis/diagnosis , Zoonoses , Fever , Hemorrhage
10.
Rev. cuba. pediatr ; 93(2): e887, tab
Article in Spanish | LILACS, CUMED | ID: biblio-1280371

ABSTRACT

Introducción: El síndrome de fiebre periódica, estomatitis aftosa, faringitis y adenitis es un cuadro relativamente frecuente de curso autolimitado y buen pronóstico. Es la más común de las enfermedades autoinflamatorias que presentan fiebre recurrente y su etiología y fisiopatogenia permanecen inciertas. Objetivo: Describir el caso clínico de un niño que consultó por fiebre recurrente y faringitis y se arribó al diagnóstico de síndrome de fiebre periódica, estomatitis aftosa, faringitis y adenitis. Presentación del caso: Se trata de un paciente de 5 años que consultó por un episodio febril acompañado de faringitis y adenitis, con antecedente de múltiples episodios previos. Conclusiones: El síndrome fiebre periódica, estomatitis aftosa, faringitis y adenitis, es una entidad de curso benigno y autolimitado que constituye la causa más común de fiebre recurrente con un gran impacto en la vida de los pacientes. La fisiopatogenia permanece incierta. Es destacable la sospecha clínica para arribar al diagnóstico ya que no existen en la actualidad exámenes complementarios específicos(AU)


Introduction: Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome is a relatively common picture of self-limiting course and good prognosis. It is the most common of self-inflammatory diseases with recurrent fever and its etiology and physiopathology remain uncertain. Objective: Describe the clinical case of a boy who was checked due recurrent fever and pharyngitis and being diagnosed with Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Case presentation: This is a 5-year-old patient who was consulted due to a febrile episode accompanied by pharyngitis and adenitis, with a history of multiple previous episodes. Conclusions: Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome is a benign, self-limiting course entity that is the most common cause of recurrent fever with a large impact on patients' lives. Its physiopathology remains uncertain. Clinical suspicion for diagnosis is noteworthy as there are currently no specific complementary test for it(AU)


Subject(s)
Humans , Male , Child, Preschool , Relapsing Fever , Stomatitis, Aphthous , Pharyngitis , Fever , Lymphadenitis
11.
Ciênc. Saúde Colet ; 26(2): 445-454, fev. 2021. graf
Article in English, Portuguese | LILACS | ID: biblio-1153798

ABSTRACT

Resumo O estudo analisa a compreensão de pais ou responsáveis por crianças de zero a cinco anos acerca da febre, da condução e do atendimento desse quadro, realizado no serviço de urgência e emergência. A pesquisa qualitativa, por meio da técnica de análise temática, foi feita a partir de entrevistas com 14 pais ou responsáveis que procuraram um serviço pediátrico de urgência e emergência em um município do interior de São Paulo por esse motivo. Os dados coletados foram analisados por meio da técnica de análise temática. As experiencias dos pais que procuram esses serviços relacionam-se a três temas principais: temor da febre; os cuidados com criança febril; e a experiência de atendimento no serviço de urgência e emergência. Identificou-se que o medo exagerado da febre prevalece e que os pais/responsáveis se sentem seguros frente à tecnologia existente nos serviços de urgência e emergência. Os cuidados adotados, todavia, nem sempre são os recomendados para a situação apresentada.


Abstract The study analyses the understanding of parents or guardians of children aged zero to five years old about fever, the conduct and care for this condition, carried out in the urgent and emergency service. The qualitative research, which used the thematic analysis technique, was carried out through interviews with 14 parents or guardians who sought an urgent and emergency Pediatric Service in a municipality in the countryside of São Paulo for this reason. The experiences of parents who seek these services are associated to three main topics: fear of fever; care for a febrile child; and the experience of care at the urgent and emergency services. It was identified that an exaggerated fear of fever predominates and that parents / guardians feel safe regarding the existing technology found in urgent and emergency services. The adopted precautions, however, are not always those recommended for the existing situation.


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Parents , Emergency Medical Services , Brazil , Qualitative Research , Fever/therapy , Fever/epidemiology
12.
Bol. méd. postgrado ; 37(1): 68-72, Ene-Jun 2021. ilus
Article in Spanish | LILACS, LIVECS | ID: biblio-1147883

ABSTRACT

Según datos de la OMS, la tuberculosis es una de las diez primeras causas de muerte en el mundo y es la primera causa de muerte por un agente infeccioso único. La incidencia de la tuberculosis ha disminuido por término medio un 1,5% anual desde el año 2000 sin embargo el impacto de la pandemia por el SARS-CoV-2 pudiera retardar el diagnóstico y tratamiento de nuevos casos de TB. Se presenta el caso de un paciente masculino de 26 años de edad quien consulta por presentar fiebre de predominio vespertino, pérdida de peso y disfonía de 6 meses de evolución. Los BK y cultivos de esputo seriados resultaron negativos. Es referido al Servicio de Otorrinolaringología y Cirugía Facial del Hospital Universitario Dr. Luis Gómez López donde se realiza una nasofibrolaringoscopía evidenciándose epiglotis con superficie de aspecto irregular que se extiende hasta aritenoides y zona interaritenoidea y bandas ventriculares edematizadas que no permiten visualizar repliegues vocales. Se realiza microcirugía laríngea para toma de biopsia reportando el estudio histopatológico proliferación de vasos neoformados, espacios intervasculares ocupados por macrófagos y linfocitos, presencia de múltiples lesiones nodulares formadas por macrófagos epiteloides rodeados por un halo de linfocitos y numerosas células gigantes de Langerhans. Se realiza el diagnóstico de tuberculosis laríngea y se inicia tratamiento antituberculoso(AU)


According to the WHO, tuberculosis represents one of the top ten causes of death worldwide and is the number one cause of death from a single infectious agent. The incidence of tuberculosis has decreased an average of 1.5% annually since the year 2000, however the impact of the SARS-CoV-2 pandemic could delay the diagnosis and treatment of new cases of TB. We report the case of a 26-year-old male who consulted for fever, weight loss and dysphonia with a duration of 6 months. BK and sputum cultures were negative for M. tuberculosis. The patient is referred to the Otorhinolaryngology and Facial Surgery Clinic of the Dr. Luis Gomez Lopez University Hospital where a nasofibrolaryngoscopy is performed showing an epiglottis with an irregular surface that extends to the arytenoids and interarytenoid zone and edematous ventricular bands that do not allow visualization of vocal folds. Laryngeal microsurgery is performed to obtain a biopsy sample. Histopathology reveals proliferation of newly formed vessels, intervascular spaces occupied by macrophages and lymphocytes, presence of multiple nodular lesions formed by epithelloid macrophages surrounded by a halo of lymphocytes and numerous giant Langerhans cells. Diagnosis of laryngeal tuberculosis is made and antituberculous treatment is initiated(AU)


Subject(s)
Humans , Male , Adult , Signs and Symptoms , Diagnostic Imaging , Tuberculosis, Laryngeal/mortality , Tuberculosis, Laryngeal/drug therapy , Dysphonia , Fever
13.
Bol. méd. postgrado ; 37(1): 27-33, Ene-Jun 2021. tab
Article in Spanish | LILACS, LIVECS | ID: biblio-1147875

ABSTRACT

Se realizó una investigación descriptiva transversal retrospectiva con el fin de determinar el perfil clínico y epidemiológico de la enfermedad de Kawasaki (EK) en 95 niños egresados del Hospital Pediátrico Dr. Agustín Zubillaga durante el período 2014-2017. El promedio de edad de los pacientes se ubicó en 3,9 ± 3,3 años, siendo 69,5% del sexo masculino. El tiempo de evolución de la enfermedad fue menor de 10 días en el 68,4% de los casos. Las manifestaciones clínicas predominantes fueron fiebre (100%), edema y/o descamación de palmas y plantas (85,3%), alteración de la mucosa oral (65,3%), inyección conjuntival (59%) y eritema polimorfo (55,8%). El tratamiento recibido consistió en aspirina (100%) e inmunoglobulina (96,8%). La respuesta al tratamiento fue satisfactoria en el 95,8% de los pacientes. Los hallazgos de laboratorio evidenciaron una PCR elevada (51,6%) y trombocitosis (97,9%) con hemoglobina normal en 62,1% de los casos. 41% de los pacientes presentaron ecocardiograma anormal y 97,9% presentaron ultrasonido abdominal normal. El diagnóstico de ingreso de la EK fue incompleto en 53,7% de los pacientes y el diagnóstico de egreso de la EK fue completo en 51,6%. Los resultados de este estudio brindan datos epidemiológicos recientes sobre la enfermedad de Kawasaki en nuestra institución prestadora de salud(AU)


A descriptive cross-sectional retrospective investigation was carried out to evaluate the clinical and epidemiological profile of Kawasaki disease (KD) in 95 children discharged from the Pediatric Hospital Dr. Agustín Zubillaga during the period 2014-2017. Mean age of children was 3.9 ± 3.3 years and 69.5% were male. Time of symptom onset was less than ten days in 68.4% patients. Predominant clinical manifestations were fever (100%), edema and/or desquamation of palms and soles (85.3%), alteration of the oral mucosa (65.3%), conjunctival injection (59%) and polymorphic erythema (55.8%). Treatment received included aspirin (100%) and immunoglobulin (96.8%). Response to treatment was satisfactory in 95.8% of cases. Laboratory findings showed elevated CRP (51.6%), thrombocytosis (97.9%) and normal hemoglobin in 62.1% patients. 41% had an abnormal echocardiogram and 97.9% showed a normal abdominal ultrasound. The diagnosis of CHD admission was incomplete in 53.7% of cases and the diagnosis of EK was complete in 51.6%. Results of this study show recent epidemiological data about Kawasaki disease in our healthcare institution(AU)


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Immunoglobulins/therapeutic use , Aspirin/therapeutic use , Clinical Laboratory Techniques , Coronary Disease/etiology , Mucocutaneous Lymph Node Syndrome/epidemiology , Signs and Symptoms , Vasculitis , Edema , Fever
15.
Mem. Inst. Oswaldo Cruz ; 116: e200552, 2021. graf
Article in English | LILACS | ID: biblio-1250362

ABSTRACT

Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). SARS-CoV-2, the coronavirus discovered in Hubei province, China, at the end of 2019, became known worldwide for causing coronavirus disease 2019 (COVID-19). Over one year's time period, the scientific community has produced a large bulk of knowledge about this disease and countless reports about its immune-pathological aspects. This knowledge, including data obtained in postmortem studies, points unequivocally to a hypercoagulability state. However, the name COVID-19 tells us very little about the true meaning of the disease. Our proposal is more comprehensive; it intends to frame COVID-19 in more clinical terminology, making an analogy to viral haemorrhagic fever (VHF). Thus, we found irrefutable evidence in the current literature that COVID-19 is the first viral disease that can be branded as a viral thrombotic fever. This manuscript points out that SARS-CoV-2 goes far beyond pneumonia or SARS. COVID-19 infections promote remarkable interactions among the endothelium, coagulation, and immune response, building up a background capable of promoting a "thrombotic storm," much more than a "cytokine storm." The importance of a viral protease called main protease (Mpro) is highlighted as a critical component for its replication in the host cell. A deeper analysis of this protease and its importance on the coagulation system is also discussed for the first time, mainly because of its similarity with the thrombin and factor Xa molecules, as recently pointed out by structural comparison crystallographic structures.


Subject(s)
Humans , COVID-19 , China , Fever , SARS-CoV-2
17.
Acta Paul. Enferm. (Online) ; 34: eAPE00743, 2021. tab, graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1278065

ABSTRACT

Resumo Objetivo: Identificar as intervenções não farmacológicos para febre e hipertermia em crianças indicados na literatura científica. Métodos: Trata-se de uma revisão integrativa da literatura realizada nas bases de dados Lilacs, PubMed e CINAHL e as bibliotecas COCHRANE e SciELO. Foram incluídos artigos que abordassem as intervenções não farmacológicas para febre e hipertermia, publicados em português e inglês, no período de 2000 a 2019. Resultados: A amostra foi constituída por 27 artigos, que foram agrupados, conforme suas similaridades, em sete categorias. As intervenções utilizadas foram: banhos; compressas mornas; sponging ; incentivo à ingestão de líquidos; bolsas de gelo e cobertores refrigerados; e, por último, a categoria ventilação do ambiente. Observaram-se diferentes intervenções no manejo não farmacológico de febre e hipertermia. Conclusão: A prática de medidas não farmacológicas isoladamente não é recomendada para o tratamento de febre em crianças, exceto as intervenções que auxiliem nas respostas fisiológicas do corpo. Os resultados ressaltam a recomendação da realização de novas pesquisas que redundem em evidências para fundamentar o melhor cuidado do enfermeiro pediatra à criança com febre.


Resumen Objetivo: Identificar las intervenciones no farmacológicas para la fiebre e hipertermia en niños recomendadas en la literatura científica. Métodos: Se trata de una revisión integradora de la literatura realizada en las bases de datos Lilacs, PubMed y CINAHL y las bibliotecas COCHRANE y SciELO. Se incluyeron artículos que abordaran las intervenciones no farmacológicas para la fiebre e hipertermia, publicados en portugués e inglés, en el período de 2000 a 2019. Resultados: La muestra estuvo compuesta por 27 artículos, que fueron agrupados en siete categorías según sus similitudes. Las intervenciones utilizadas fueron: baños, compresas tibias, sponging , incentivo a la ingesta de líquidos, bolsas de hielo y mantas refrigeradas y, por último, la categoría ventilación del ambiente. Se observaron diferentes intervenciones en el manejo no farmacológico de la fiebre e hipertermia. Conclusión: No se recomienda la práctica de medidas no farmacológicas de forma aislada para tratar la fiebre en niños, excepto las intervenciones que ayuden a las respuestas fisiológicas del cuerpo. Los resultados resaltan la recomendación de realizar nuevos estudios que tengan como resultado evidencias para fundamentar un mejor cuidado del enfermero pediatra a niños con fiebre.


Abstract Objective: To identify non-pharmacological interventions for fever and hyperthermia in children indicated in the scientific literature. Methods: an integrative literature review carried out in the LILACS, PubMed and CINAHL databases and in the COCHRANE and SciELO libraries. Articles that addressed non-pharmacological interventions for fever and hyperthermia, published in Portuguese and English, from 2000 to 2019, have been included. Results: The sample consisted of 27 articles, which were grouped, according to their similarities, into seven categories. The interventions used were baths, warm compresses, sponging, encouraging fluid intake, ice packs, cooled blankets, and room ventilation. Different interventions were observed in non-pharmacological fever and hyperthermia management. Conclusion: Practicing non-pharmacological measures alone is not recommended for fever treatment in children, except for interventions that assist in the physiological responses of the body. The results highlight the recommendation of conducting further research that results in evidence to support the best care provided by pediatric nurses to children with fever.


Subject(s)
Humans , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Pediatric Nursing , Review Literature as Topic , Fever/therapy , Hyperthermia/therapy , Nursing Care
18.
Ciênc. cuid. saúde ; 20: e57572, 2021. graf
Article in Portuguese | LILACS, BDENF | ID: biblio-1356106

ABSTRACT

RESUMO Introdução: A principal causa de mortalidade pelo novo coronavírus é a insuficiência respiratória. Assim, os cuidados intensivos devem ser prontamente prestados ao paciente crítico. Objetivo: Explorar as evidências acerca dos achados clínicos, tratamento e desfecho de pacientes infectados pelo Sars-CoV-2 internados em Unidades de Terapia Intensiva. Método: Revisão de escopo, realizada em abril de 2021, em oito fontes de dados nacionais e internacionais, conforme orientações do Instituto Joanna Briggs, seguindo o checklist Preferred Reporting Items for Systematic reviews and Meta-Analysesextension for Scoping Reviews, sem restrição de idioma ou temporal. Adotou-se a estratégia Population, Concept and Contextpara a elaboração da questão de pesquisa. Resultados: Incluíram-se 15 artigos científicos, com predominância de publicações na China, Estados Unidos da América e Canadá. Dos estudos, 80% foram com adultos e idosos em Unidade de Terapia Intensiva. Os principais achados clínicos foram a febre, tosse, Síndrome do Desconforto Respiratório Agudo e lesão renal, tratamento com ventilação mecânica invasiva e não invasiva, oxigenoterapia de alto fluxo e corticoesteroides. Como principal desfecho, o óbito. Conclusão: A maioria dos pacientes apresentou febre, tosse e Síndrome do Desconforto Respiratório Agudo, recebendo cuidados como ventilação mecânica, oxigenoterapia de alto fluxo e corticoesteroides, com alto índice de óbitos.


RESUMEN Introducción: La principal causa de mortalidad por el nuevo coronavirus es la insuficiencia respiratoria. Por lo tanto, los cuidados intensivos deben ser proporcionados rápidamente al paciente crítico. Objetivo: Explorar las evidencias acerca de los hallazgos clínicos, tratamiento y desenlace de pacientes infectados por el Sars-CoV-2 internados en Unidades de Cuidados Intensivos. Método: Scoping review, realizada en abril de 2021, en ocho fuentes de datos nacionales e internacionales, conforme orientaciones del Instituto Joanna Briggs, siguiendo el check list Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, sin restricción de idioma o temporal. Se adoptó la estrategia Population, Concept and Context para la elaboración de la cuestión de investigación. Resultados: Se incluyeron 15 artículos científicos, con predominio de publicaciones en China, Estados Unidos de América y Canadá. De los estudios, el 80% fue con adultos y ancianos en Unidad de Cuidados Intensivos. Los principales hallazgos clínicos fueron fiebre, tos, Síndrome Respiratorio Agudo Severo y lesión renal, tratamiento con ventilación mecánica invasiva y no invasiva, oxigenoterapia de alto flujo y corticoesteroides. Como principal desenlace: el óbito. Conclusión: La mayoría de los pacientes presentó fiebre, tos y Síndrome Respiratorio Agudo Severo, recibiendo cuidados como ventilación mecánica, oxigenoterapia de alto flujo y corticoesteroides, con alto índice de óbitos.


ABSTRACT Introduction: The leading cause of mortality from the new coronavirus is respiratory failure. Accordingly, intensive care must be promptly provided to the critically ill patient. Objective: To explore the evidence about the clinical findings, treatment and outcome of Sars-CoV-2 infected patients admitted to Intensive Care Units. Method: Scoping review, carried out in April 2021, in eight national and international data sources, according to the guidelines of the Joanna Briggs Institute, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews checklist, without language or time restrictions. The Population, Concept and Context strategy was adopted for the development of the research question. Results: A total of 15 scientific articles were included, with a predominance of publications in China, the United States of America and Canada. Of the studies, 80% were with adults and elderly in Intensive Care Unit. The main clinical findings were fever, cough, Acute Respiratory Distress Syndrome and kidney injury, treatment with invasive and non-invasive mechanical ventilation, high flow oxygen therapy and corticosteroids. The main outcome was death. Conclusion: Most patients presented with fever, cough and Acute Respiratory Distress Syndrome, receiving care such as mechanical ventilation, high flow oxygen therapy and corticosteroids, with a high death rate.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Patients , COVID-19 , Oxygen Inhalation Therapy , Patient Discharge , Respiration, Artificial , Respiratory Distress Syndrome, Newborn , Respiratory Insufficiency , Signs and Symptoms , Comorbidity , Mortality , Adrenal Cortex Hormones , Coronavirus Infections , Cough , Critical Care , Dyspnea , Acute Kidney Injury , Fever , Hospitalization , Intensive Care Units , Anti-Bacterial Agents
19.
Rev. Investig. Salud. Univ. Boyacá ; 8(1): 170-185, 20210000.
Article in Spanish | LILACS, COLNAL | ID: biblio-1358975

ABSTRACT

Introducción: La fiebre se considera uno de los primeros síntomas registrados en pacientes hospitalizados y se ha convertido en un importante marcador de enfermedad. La presente revisión buscó recopilar evidencia en torno a la fiebre y su importancia en los diferentes escenarios clínicos que se presentan en el paciente neurológico, ya que en los últimos años se ha logrado comprender mejor el papel que desempeña el sistema nervioso central dentro de la termorregulación. Metodología: Búsqueda de la literatura en bases de datos como Pubmed, OVID, Epistemonikos, SciELO y Google Scholar, durante los años 2009 al 2019 en español e inglés, sobre fiebre e implicaciones en pacientes neurológicos, usando palabras clave como fiebre, sensibilidad, especificidad, likelihood ratio, enfermedades del sistema nervio-so, neurología, encefalitis, neuritis y traumatismo del sistema nervioso. Resultados: Se encontraron 374 artículos, de los cuales 48 cumplieron con los criterios de inclusión. Se incluyeron libros de texto, como metaanálisis, revisiones sistemáticas, revisiones scoping, artículos de revisión y estudios ob-servacionales. Se analizaron y subdividieron en 8 apartados con temáticas en común para su estudio. Conclusiones: En etapas tempranas de eventos cerebro-vasculares isquémicos o hemorrágicos la fiebre se com-porta como una respuesta sistémica secundaria al daño de base, y es crucial corregirla tempranamente. Al mismo tiempo, en traumatismos del sistema nervioso central, la fiebre en las primeras 72 horas se identifica como un marcador de mal pronóstico


Introduction: Fever is considered one of the first symptoms registered in hospitalized patients, beco-ming an important marker of disease. The present review sought to collect evidence on fever and its importance in the different clinical scenarios that occur in neurological patients, since in recent years it has been possible to better understand the role of the central nervous system within the thermo-regulation. Methodology: A literature search was carried out in databases such as Pubmed, OVID, Epistemoni-kos, SciELO and Google Scholar during the years 2009 to 2019 in Spanish and English languages, on fever and implications in neurological patients, using keywords such as fever, sensitivity, specificity, likelihood ratio, diseases of the nervous system, neurology, encephalitis, neuritis and trauma of the nervous system. Results: A total of 374 articles were found, of which 48 articles met the inclusion criteria, for the construction of this review article. Textbooks, as well as meta-analyzes, systematic reviews, scoping reviews, and review articles were included. They were analyzed and subdivided into 8 sections with common themes for their study. Conclusions: In early stages of ischemic or hemorrhagic CVD, fever behaves as a systemic response secondary to the underlying injury, and it is crucial to correct it early. At the same time, in CNS trauma, fever in the first 72 hours is identified as a poor prognostic marker


Introdução: A febre é considerada um dos primeiros sintomas registrados em pacientes hospitaliza-dos e tornou-se um importante marcador de doença. A presente revisão procurou reunir evidencias em torno da febre e sua importância nos diferentes panoramas clínicos no paciente neurológico, uma vez que nos últimos anos foi possível compreender melhor o papel do sistema nervoso central no processo de termo regulação. Metodologia: Foi realizada uma pesquisa de literatura em bases de dados como Pubmed, OVID, Epis-temonikos, SciELO e Google Acadêmico, durante os anos 2009 a 2019 em espanhol e inglês, sobre febre e suas implicações em pacientes neurológicos, utilizando palavras-chave como febre, sensibili-dade, especificidade, likelihood ratio, doenças do sistema nervoso, neurologia, encefalite, neurite e trauma do sistema nervoso. Resultados: Foi encontrado um total de 374 artigos, dos quais 48 abrangiam os critérios de inclusão. Foram incluídos livros de texto, como meta-análises, revisões sistemáticas, revisões Scoping, artigos de revisão e estudos observacionais. Foram analisadas e subdivididas em 8 secções com assuntos comuns para seu estudo. Conclusões: Em fases iniciais de eventos cerebrovasculares isquêmicos ou hemorrágicos, a febre se comporta como uma resposta sistêmica secundária ao dano de base, e é crucial corrigi-la precoce-mente. Enquanto, em traumatismos do sistema nervoso central, a febre nas primeiras 72 horas é identificada como um marcador de mau prognóstico


Subject(s)
Fever , Diagnosis , Nervous System Diseases , Neurology
20.
Rev. gaúch. enferm ; 42(spe): e20200205, 2021. tab, graf
Article in English | LILACS, BDENF | ID: biblio-1251789

ABSTRACT

ABSTRACT Objective To identify symptoms of COVID-19 in adults in the scientific literature. Method Systematic review of studies published from December 1, 2019 to April 21, 2020 from the Scopus, Web of Science and PubMed databases, in order to answer the following research question: "What are the symptoms caused by COVID-19 in adults?" using the keywords "Symptoms", "Clinical Manifestations", "Coronavirus", "COVID-19". Results Of the total 105 references, 13 references that addressed the symptoms of COVID-19 were selected. Fever and normal or dry cough were symptoms present in all studies. Conclusion The symptoms identified in adult patients were fever, normal or dry cough, headache, pharyngalgia, dyspnea, diarrhea, myalgia, vomiting, sputum or expectoration, anxiety or chest pain, fatigue, nausea, anorexia, abdominal pain, rhinorrhea, runny nose or nasal congestion, dizziness, chills, systemic pain, mental confusion, hemoptysis, asthma, taste disorder, smell disorder, belching and tachycardia.


RESUMEN Objetivo Verificar en la literatura científica las manifestaciones sintomáticas de COVID-19 en adultos. Método Una revisión sistemática realizada en las bases de datos Scopus, Web of Science y PubMed con estudios publicados del 1 de diciembre de 2019 al 21 de abril de 2020, con el fin de responder a la pregunta orientadora: "¿Cuáles son las manifestaciones sintomáticas causada por COVID-19 en adultos?" utilizando las palabras clave: "Síntomas", "Manifestaciones clínicas", "Coronavirus", "COVID-19". Resultados Del total de 105 referencias, se seleccionaron 13 que abordaron las manifestaciones sintomáticas de COVID-19, con fiebre y tos normal o seca presente en todos los estudios. Conclusión Las manifestaciones sintomáticas identificadas en pacientes adultos fueron: fiebre, tos normal o seca, dolor de cabeza, faringalgia, disnea, diarrea, mialgia, vómitos, esputo o expectoración, angustia o dolor en el pecho, fatiga, náuseas, anorexia, dolor abdominal, rinorrea, secreción nasal o congestión nasal, mareos, escalofríos, dolor sistémico, confusión mental, hemoptisis, asma, alteración del gusto, alteración del olfato, eructos y taquicardia.


RESUMO Objetivo Verificar na literatura científica as manifestações sintomáticas da COVID-19 em pessoas adultas. Método Revisão sistemática utilizando as bases Scopus, Web of Science e PubMed com estudos publicados de 1 de dezembro de 2019 a 21 de abril de 2020, a fim de responder à questão norteadora: "Quais as manifestações sintomáticas causada pela COVID-19 em pessoas adultas?" utilizando-se as palavras-chave: "Symptoms", "Clinical Manifestations", "Coronavirus", "COVID-19". Resultados Do total de 105 referências, foram selecionadas 13 que abordaram as manifestações sintomáticas da COVID-19, estando a febre e a tosse normal ou seca presente em todos os estudos. Conclusão As manifestações sintomáticas identificadas nos pacientes adultos foram: febre, tosse normal ou seca, cefaleia, faringalgia, dispneia, diarreia, mialgia, vômito, escarro ou expectoração, angústia ou dor no peito, fadiga, náusea, anorexia, dor abdominal, rinorreia, coriza ou congestão nasal, tontura, calafrios, dor sistêmica, confusão mental, hemoptise, asma, comprometimento do paladar, comprometimento do olfato, arroto e taquicardia.


Subject(s)
Humans , Male , Female , Adult , General Symptoms , SARS-CoV-2 , COVID-19 , Asthma , Vomiting , Anorexia , Databases, Bibliographic , Cough , Ageusia , Diarrhea , Dizziness , Fatigue , Fever , Olfaction Disorders
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