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1.
Rev. colomb. cancerol ; 24(3): 130-139, jul.-set. 2020. graf
Article in Spanish | LILACS | ID: biblio-1144332

ABSTRACT

Resumen El tumor desmoplásico de célula redonda y pequeña (TDCRP) es una patología neoplásica maligna agresiva y poco común. Afecta predominantemente a hombres entre la segunda y tercera década de la vida. Los pacientes que la padecen tienen un pronóstico pobre, con una supervivencia global a 5 años de hasta el 30%. Por lo general se presenta como una masa en la cavidad abdominal, frecuentemente multifocal. Para su tratamiento se recomienda un enfoque multimodal con cirugía, quimioterapia y radioterapia. Poco más de 20 casos de TDCRP a nivel testicular/paratesticular se han reportado en la literatura. A continuación, se presenta un caso ilustrativo en esta localización, se discute el caso y se realiza revisión de la literatura.


Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive and rare malignant neoplasm. It mainly affects young men in their twenties and thirties. Patients with it have a poor prognosis, with a 5-year survival rate of up to 30%. It generally presents as a mass in the abdominal cavity, often multifocal. A multimodal approach is recommended for its treatment, with surgery, chemotherapy, and radiotherapy. Just over 20 cases of testicular/paratesticular DSRCT have been reported in the literature. Below, we present an illustrative case in this location, we discuss the case and review the literature.


Subject(s)
Humans , Male , Adult , Retroperitoneal Neoplasms/diagnosis , Retroperitoneal Neoplasms/therapy , Desmoplastic Small Round Cell Tumor/diagnosis , Desmoplastic Small Round Cell Tumor/therapy , Genital Neoplasms, Male/diagnosis , Genital Neoplasms, Male/therapy , Testicular Neoplasms/diagnosis , Testicular Neoplasms/therapy , Ganglia
2.
An. bras. dermatol ; 94(6): 721-723, Nov.-Dec. 2019. graf
Article in English | LILACS | ID: biblio-1054886

ABSTRACT

Abstract Primary male genital melanomas are very rare; they are associated with high mortality and late detection. Scrotal melanoma is the least common presentation and only 23 cases have been reported. Herein, the authors present a 30-year-old patient with stage IIIC (T4b, N2a, M0) scrotal melanoma in order to report the characteristics, treatment, and outcome, as well as to emphasize the importance of examination of the genitals, education of patients about self-examination and destigmatizing genital lesions to increase the likelihood of earlier detection.


Subject(s)
Humans , Male , Adult , Scrotum/pathology , Skin Neoplasms/pathology , Genital Neoplasms, Male/pathology , Melanoma/pathology , Skin Neoplasms/drug therapy , Biopsy , Interferon alpha-2/administration & dosage , Genital Neoplasms, Male/drug therapy , Melanoma/drug therapy , Neoplasm Staging , Antineoplastic Agents/administration & dosage
3.
Rev. chil. radiol ; 24(3): 117-124, jul. 2018. tab, ilus
Article in Spanish | LILACS | ID: biblio-978165

ABSTRACT

Presentamos un caso de Angiomiofibroblastoma-like (AML), en el que la ecografía fue importante para determinar la detección, localización y extensión local. Hallazgos: La ecografía demostró una lesión paratesticular sólida hipoecogénica de bordes bien definidos lo que sugirió lesión benigna extratesticular. La histología evidenció una neoplasia mesenquimal benigna tipo mixoide en cuyo diagnóstico diferencial se incluyen el Angiomixoma superficial (AMS), Angiomixoma agresivo (AMA), Angiomiofibroblastoma (AMF) y el AML. En base a estos hallazgos se realizó una revisión de tumores de similares características en la literatura, llegando finalmente al diagnóstico de AML cuya localización paratesticular sólo ha sido descrita en muy pocos casos hasta la fecha. Conclusión: La ecografía es útil para localizar los tumores paratesticulares y determinar su extensión local. No obstante, para llegar al diagnóstico definitivo es necesario realizar un estudio histológico e inmunohistoquímico de la tumoración.


We present a case of a paratesticular Angiomiofibroblastoma-like (AML) tumor in which ultrasound was important to give the specific location and local extension of the lesion. Findings: Ultrasound revealed a hypoechoic paratesticular lesion with well-defined borders, suggesting an extratesticular benign lesion. The histology showed a benign mesenchymal myxoid-type neoplasm. The differential diagnosis included superficial Angiomyxoma (AMS), Aggressive angiomyxoma (AMA), Angiomyofibroblastoma (AMF) and AML. Based on these findings, a review of similar tumors was carried out and ultimately led to the diagnosis of paratesticular AML. This location has been described only in a few cases in the literature. Conclusion: Ultrasound is useful to locate paratesticular tumors and determine their local extension. However, a definitive diagnosis still requires a histological and immunohistochemical study.


Subject(s)
Humans , Male , Middle Aged , Angiofibroma/surgery , Angiofibroma/diagnostic imaging , Genital Neoplasms, Male/surgery , Genital Neoplasms, Male/pathology , Immunohistochemistry , Tomography, X-Ray Computed , Ultrasonography , Angiofibroma/pathology , Diagnosis, Differential
4.
Clinics ; 73(supl.1): e551s, 2018. graf
Article in English | LILACS | ID: biblio-952836

ABSTRACT

Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Human papillomaviruses mediate cell transformation by the expression of two pleiotropic oncoproteins that alter major cellular regulatory pathways. However, these viruses are not complete carcinogens, and further alterations within the infected cells and in their microenvironment are necessary for tumor establishment and progression. Alterations in components of the extracellular matrix for instance, matrix metalloproteinases and some of their regulators such as tissue inhibitors of metalloproteinases, have been consistently reported in human papillomaviruses-associated diseases. Matrix metalloproteinases function by remodeling the extracellular matrix and alterations in their expression levels and/or activity are associated with pathological processes and clinical variables including local tumor invasion, metastasis, tumor relapse and overall patient prognosis and survival. In this review we present a summarized discussion on the current data concerning the impact of human papillomavirus infection on the activity and expression of extracellular matrix components. We further comment on the possibility of targeting extracellular matrix molecules in experimental treatment protocols.


Subject(s)
Humans , Male , Female , Cell Transformation, Neoplastic/metabolism , Papillomavirus Infections/metabolism , Extracellular Matrix/metabolism , Papillomavirus Infections/virology , Genital Neoplasms, Female/virology , Genital Neoplasms, Male/virology , Head and Neck Neoplasms/virology
5.
National Journal of Andrology ; (12): 525-528, 2018.
Article in Chinese | WPRIM | ID: wpr-689697

ABSTRACT

<p><b>Objective</b>To explore the practicability and safety of the F4.8 visual miniature nephroscope in the diagnosis and treatment of hematospermia.</p><p><b>METHODS</b>This study included 12 cases of refractory hematospermia accompanied by perineal or lower abdominal pain and discomfort. All the patients failed to respond to two months of systemic anti-inflammatory medication and local physiotherapy. Seminal vesicle tumor and tuberculosis were excluded preoperatively by rectal seminal vesicle ultrasonography, MRI or CT. Under epidural anesthesia, microscopic examination was performed with the F4.8 miniature nephroscope through the urethra and ejaculatory duct orifice into the seminal vesicle cavity, the blood clots washed out with normal saline, the seminal vesicle stones extracted by holmium laser lithotripsy and with the reticular basket, the seminal vesicle polyps removed by holmium laser ablation and vaporization, and the seminal vesicle cavity rinsed with diluted iodophor after operation.</p><p><b>RESULTS</b>Of the 10 patients subjected to bilateral seminal vesiculoscopy, 3 with unilateral and 2 with bilateral seminal vesicle stones were treated by holmium laser lithotripsy, saline flushing and reticular-basket removal, 2 with seminal vesicle polyps by holmium laser ablation and vaporization, and the other 3 with blood clots in the seminal vesicle cavity by saline flushing for complete clearance. The 2 patients subjected to unilateral seminal vesiculoscopy both received flushing of the seminal vesicle cavity for clearance of the blood clots. The operations lasted 10-55 (25 ± 6) minutes. There were no such intra- or post-operative complications as rectal injury, peripheral organ injury, and external urethral sphincter injury. The urethral catheter was removed at 24 hours, anti-infection medication withdrawn at 72 hours, and regular sex achieved at 2 weeks postoperatively. The patients were followed up for 6-20 (7 ± 2.3) months, during which hematospermia and related symptoms disappeared in 10 cases at 3 months and recurrence was observed in the other 2 at 4 months after surgery but improved after antibiotic medication.</p><p><b>CONCLUSIONS</b>The F4.8 visual miniature nephroscope can be applied to the examination of the seminal vesicle cavity and treatment of seminal vesicle stones and polyps, with the advantages of minimal invasiveness, safety and reliability.</p>


Subject(s)
Calculi , Diagnostic Imaging , General Surgery , Ejaculatory Ducts , Endoscopes , Endoscopy , Genital Neoplasms, Male , Hemospermia , Diagnosis , Therapeutics , Holmium , Humans , Lasers, Solid-State , Lithotripsy , Magnetic Resonance Imaging , Male , Natural Orifice Endoscopic Surgery , Neoplasm Recurrence, Local , Postoperative Complications , Reproducibility of Results , Seminal Vesicles , Diagnostic Imaging , Urethra
6.
National Journal of Andrology ; (12): 639-645, 2017.
Article in Chinese | WPRIM | ID: wpr-812902

ABSTRACT

Objective@#To investigate the clinicopathological characteristics, diagnosis, and treatment of primary seminal vesicle adenocarcinoma (SVAC).@*METHODS@#We analyzed the clinical data and clinicopathological characteristics of 4 cases of primary SVAC treated in the Department of Urology of the Second Hospital of Tianjin Medical University and reviewed relevant literature.@*RESULTS@#All the 4 patients were treated by open radical resection of the seminal vesicle and prostate and pathologically diagnosed with SVAC. Preoperative prostatic biopsy had shown 1 of the cases to be negative, while preoperative CT and transrectal ultrasound had revealed a huge pelvic cystic neoplasm in another patient. Immunohistochemistry manifested that the 4 cases were all negative for prostate-specific antigen (PSA), prostatic acid phosphatase (PAP), and cytokeratin 20 (CK20), but positive for cancer antigen 125 (CA125) and CK7. All the patients recovered smoothly after surgery and experienced no recurrence or metastasis during 154, 41, 20, and 12 months of follow-up.@*CONCLUSIONS@#Primary seminal vesicle carcinoma is extremely rare and presents in an advanced stage. Immunohistochemistry plays a valuable role in its differential diagnosis. Various combinations of radical surgery, radiotherapy, androgen-deprivation therapy, and chemotherapy are recommended for the treatment of the disease.


Subject(s)
Adenocarcinoma , Chemistry , Pathology , General Surgery , Biopsy , CA-125 Antigen , Diagnosis, Differential , Genital Neoplasms, Male , Chemistry , Pathology , General Surgery , Humans , Immunohistochemistry , Male , Neoplasm Recurrence, Local , Pelvic Neoplasms , Diagnostic Imaging , Prostate-Specific Antigen , Prostatectomy , Seminal Vesicles , Pathology , General Surgery
7.
National Journal of Andrology ; (12): 1103-1106, 2017.
Article in Chinese | WPRIM | ID: wpr-812826

ABSTRACT

Objective@#To report a rare case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity for the purpose of improving the diagnosis and treatment of the disease.@*METHODS@#We retrospectively analyzed the clinical data about a case of epididymal liposarcoma with multiple metastases to the retroperitoneal space and peritoneal cavity, reviewed relevant literature at home and abroad, and investigated the presentation, diagnosis and treatment of the disease.@*RESULTS@#A 47-year-old male patient with epididymal liposarcoma underwent radical left orchiectomy with high ligation of the spermmatic cord. Ten years later, recurrence and metastasis were observed in the retroperitoneal space with a mass of 15.6 × 9.4 × 25.5 cm occupying an area from the upper pole of the left kidney to the pelvic cavity and enclosing the left kidney and upper ureter, for which the patient received radical resection of the retroperitoneal tumor. However, multiple retroperitoneal and intraperitoneal metastases occurred again 4 years later, which was treated by another surgical resection. The patient died of lung failure a year later.@*CONCLUSIONS@#Epididymal liposarcoma is a rare entity, which can be diagnosed by careful clinical and radiological examinations and confirmed by pathology. For its treatment, radical inguinal orchiectomy should be performed as early as possible, but the roles of adjuvant radiotherapy and chemotherapy remain controversial. Given the high rate of recurrence and metastasis, long-term follow-up is necessitated for the patient postoperatively.


Subject(s)
Epididymis , Pathology , Genital Neoplasms, Male , Pathology , Humans , Kidney , Liposarcoma , Pathology , Male , Middle Aged , Neoplasm Recurrence, Local , Orchiectomy , Peritoneal Cavity , Peritoneal Neoplasms , Retroperitoneal Neoplasms , Retroperitoneal Space
9.
Appl. cancer res ; 36: 1-11, 2016. ilus
Article in English | LILACS, Inca | ID: biblio-910951

ABSTRACT

The recently published 2016 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs stems from the accumulated knowledge and data collected during the last 12 years, since the previous edition of the WHO "blue book" 2004. The major changes in prostate pathology include the introduction of a novel grading system for prostate cancer (Grade Groups/International Society of Urological Pathology (ISUP) grades 1­5), the recognition of intraductal carcinoma as a new entity, and the terminological changes regarding the neuroendocrine prostatic neoplasms. In bladder and urothelial tract, within the spectrum of flat and non-invasive lesions, a newly introduced term "urothelial proliferation of uncertain malignant potential" replaced the term "urothelial hyperplasia", and the term "urothelial dysplasia" was better defined. A category of "invasive urothelial carcinoma with divergent differentiation" was introduced for tumors showing a component of "usual type" urothelial carcinoma combined with other morphologies. A new WHO/ISUP renal tumor grading system was recommended (Grade 1­4). The definition of renal papillary adenoma was modified and expanded to include papillary neoplasms measuring up to 1.5 cm. Several new epithelial renal tumors were recognized as new entities including: hereditary leiomyomatosis and renal cell carcinoma (RCC) syndrome­associated RCC, succinate dehydrogenase­deficient RCC, tubulocystic RCC, acquired cystic disease­associated RCC, and clear cell papillary RCC. In testis pathology, intratubular proliferations of testicular germ cell tumors were renamed as "germ cell neoplasia in-situ" (GCNIS), and the testicular neoplasms were divided into two main groups: derived from or unrelated to GCNIS. A major change in penile pathology was the introduction of a new classification of penile squamous cell carcinoma, based on the presence of human papillomavirus (HPV), which characterizes penile tumor subtypes as HPV-related or non-HPV-related. A similar distinction was introduced for the preneoplastic penile intraepithelial precursor lesion (PeIN) into non-HPV related (differentiated PeIN) and HPV-related types (undifferentiated PeIN). In this review, we provide a summary and highlight the changes in the genitourinary pathology introduced by the 2016 WHO blue book, and we also discuss some recent developments that may impact the practice of genitourinary pathology in the near future (AU)


Subject(s)
Humans , Male , Penile Neoplasms/classification , Prostatic Neoplasms/classification , Testicular Neoplasms/classification , Urinary Bladder Neoplasms/classification , Health Classifications , Urogenital Neoplasms/pathology , Urologic Neoplasms/classification , Genital Neoplasms, Male/classification , Kidney Neoplasms/classification
10.
An. bras. dermatol ; 90(2): 225-231, Mar-Apr/2015. tab, graf
Article in English | LILACS | ID: lil-741083

ABSTRACT

Paget's disease, described by Sir James Paget in 1874, is classified as mammary and extramammary. The mammary type is rare and often associated with intraductal cancer (93-100% of cases). It is more prevalent in postmenopausal women and it appears as an eczematoid, erythematous, moist or crusted lesion, with or without fine scaling, infiltration and inversion of the nipple. It must be distinguished from erosive adenomatosis of the nipple, cutaneous extension of breast carcinoma, psoriasis, atopic dermatitis, contact dermatitis, chronic eczema, lactiferous ducts ectasia, Bowen's disease, basal cell carcinoma, melanoma and intraductal papilloma. Diagnosis is histological and prognosis and treatment depend on the type of underlying breast cancer. Extramammary Paget's disease is considered an adenocarcinoma originating from the skin or skin appendages in areas with apocrine glands. The primary location is the vulvar area, followed by the perianal region, scrotum, penis and axillae. It starts as an erythematous plaque of indolent growth, with well-defined edges, fine scaling, excoriations, exulcerations and lichenification. In most cases it is not associated with cancer, although there are publications linking it to tumors of the vulva, vagina, cervix and corpus uteri, bladder, ovary, gallbladder, liver, breast, colon and rectum. Differential diagnoses are candidiasis, psoriasis and chronic lichen simplex. Histopathology confirms the diagnosis. Before treatment begins, associated malignancies should be investigated. Surgical excision and micrographic surgery are the best treatment options, although recurrences are frequent.


Subject(s)
Female , Humans , Male , Breast Neoplasms/pathology , Paget Disease, Extramammary/pathology , Paget's Disease, Mammary/pathology , Skin Neoplasms/pathology , Breast Neoplasms/therapy , Carcinoma/pathology , Carcinoma/therapy , Diagnosis, Differential , Genital Neoplasms, Male/pathology , Genital Neoplasms, Male/therapy , Nipples/pathology , Paget Disease, Extramammary/therapy , Paget's Disease, Mammary/therapy , Skin Neoplasms/therapy , Vulvar Neoplasms/pathology , Vulvar Neoplasms/therapy
11.
Article in English | WPRIM | ID: wpr-250346

ABSTRACT

Pain perception is influenced by multiple factors. The single nucleotide polymorphisms (SNPs) of some genes were found associated with pain perception. This study aimed to examine the association of the genotypes of ABCB1 C3435T, OPRM1 A118G and COMT V108/158M (valine 108/158 methionine) with pain perception in cancer patients. We genotyped 146 cancer pain patients and 139 cancer patients without pain for ABCB1 C3435T (rs1045642), OPRM1 A118G (rs1799971) and COMT V108/158M (rs4680) by the fluorescent dye-terminator cycle sequencing method, and compared the genotype distribution between groups with different pain intensities by chi-square test and pain scores between groups with different genotypes by non-parametric test. The results showed that in these cancer patients, the frequency of variant T allele of ABCB1 C3435T was 40.5%; that of G allele of OPRM1 A118G was 38.5% and that of A allele of COMT V108/158M was 23.3%. No significant difference in the genotype distribution of ABCB1 C3435T (rs1045642) and OPRM1 A118G (rs1799971) was observed between cancer pain group and control group (P=0.364 and 0.578); however, significant difference occurred in the genotype distribution of COMT V108/158M (rs4680) between the two groups (P=0.001). And the difference could not be explained by any other confounding factors. Moreover, we found that the genotypes of COMT V108/158M and ABCB1 C3435T were associated with the intensities of pain in cancer patients. In conclusion, our results indicate that the SNPs of COMT V108/158M and ABCB1 C3435T significantly influence the pain perception in Chinese cancer patients.


Subject(s)
ATP Binding Cassette Transporter, Subfamily B , Genetics , Adult , Aged , Aged, 80 and over , Alleles , Breast Neoplasms , Diagnosis , Genetics , Pathology , Catechol O-Methyltransferase , Genetics , Female , Gastrointestinal Neoplasms , Diagnosis , Genetics , Pathology , Gene Expression , Gene Frequency , Genital Neoplasms, Female , Diagnosis , Genetics , Pathology , Genital Neoplasms, Male , Diagnosis , Genetics , Pathology , Genotype , Humans , Lung Neoplasms , Diagnosis , Genetics , Pathology , Male , Middle Aged , Pain , Diagnosis , Genetics , Pathology , Pain Measurement , Pain Perception , Polymorphism, Single Nucleotide , Receptors, Opioid, mu , Genetics
12.
National Journal of Andrology ; (12): 157-160, 2015.
Article in Chinese | WPRIM | ID: wpr-319525

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinicopathological characteristics of papillary cystadenoma of the epididymis.</p><p><b>METHODS</b>Using routine pathology and immunohistochemistry, we observed the surgically obtained samples from 2 cases of papillary cystadenoma of the epididymis, analyzed their pathological features and clinical presentations, and reviewed the related literature.</p><p><b>RESULTS</b>The 2 patients were both adult males. The tumors typically manifested as painless swelling in the epididymis, with occasionally dull pain and tenesmus in 1 of the cases. Pathologically, the lesions exhibited three morphological features, i. e., dilated ducts and small cysts surrounded by fibrous connective tissue, adenoid papillary hyperplasia into the cysts embraced by fibrovascular stroma, and acidophil substance present in the cysts. Immunohistochemistry showed that the tumors were strongly positive for CK8/18, CK7, and EMA, but negative for CK20, CEA, MC, Calretenin, P53, P63, SMA, VHL, and CD10, with the positive rate of Ki-67 <1%. Follow-up visits revealed good prognosis in both cases.</p><p><b>CONCLUSION</b>Papillary cystadenoma of the epididymis is a rare benign tumor in the male urogenital system, which may be accompanied by the VHL syndrome. Surgery is the first choice for its treatment.</p>


Subject(s)
Adult , Cystadenoma, Papillary , Chemistry , Pathology , Epididymis , Genital Neoplasms, Male , Chemistry , Pathology , Humans , Immunohistochemistry , Male , von Hippel-Lindau Disease
13.
Indian J Dermatol Venereol Leprol ; 2014 Jul-Aug ; 80 (4): 381
Article in English | IMSEAR | ID: sea-154899

ABSTRACT

Background: Information is scarce about the presence of molecular alterations related to human papillomavirus (HPV) infection in squamous cell carcinomas of the genital skin and about the effect of this infection in the number of Langerhans cells present in these tumors. Aims: To determine the presence of HPV in genital skin squamous cell carcinomas and to see the relationship between HPV infection and changes in the expression of Ki-67 antigen (Ki-67), p53 protein (p53), retinoblastoma protein (pRb) and E-cadherin and to alterations in Langerhans cell density, if any. Methods: A descriptive, comparative, retrospective and cross-sectional study was performed with all the cases diagnosed as squamous cell carcinomas of the genital skin at the Dermatopathology Service from 2001 to 2011. The diagnosis was verified by histopathological examination. The presence of HPV was examined using chromogenic in situ hybridization, and protein expression was studied via immunohistochemical analysis. Results: The 34 cases studied were verified as squamous cell carcinomas and 44.1% were HPV positive. The degree of expression of pRb was 17.50% ±14.11% (mean ± SD) in HPV-positive cases and 29.74% ±20.38% in HPV-negative cases (P = 0.0236). The degree of expression of Ki-67 was 47.67% ±30.64% in HPV-positive cases and 29.87% ±15.95% in HPV-negative cases (P = 0.0273). Conclusion: HPV infection was related to lower pRb expression and higher Ki-67 expression in comparison with HPV negative samples. We could not find a relationship between HPV infection and the degree of expression of p53 and E-cadherin or with Langerhans cell density.


Subject(s)
Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/genetics , Cross-Sectional Studies , DNA Fingerprinting/methods , Female , Genital Neoplasms, Female/diagnosis , Genital Neoplasms, Female/genetics , Genital Neoplasms, Male/diagnosis , Genital Neoplasms, Male/genetics , Humans , Langerhans Cells/pathology , Male , Middle Aged , Papillomavirus Infections/diagnosis , Papillomavirus Infections/genetics , Retrospective Studies , Skin Neoplasms/diagnosis , Skin Neoplasms/genetics , Young Adult
15.
Indian J Dermatol Venereol Leprol ; 2014 Mar-Apr; 80(2): 129-133
Article in English | IMSEAR | ID: sea-154763

ABSTRACT

Background/Objective: Extramammary Paget’s Disease (EMPD) seems to be more common in Caucasians than Chinese. We report the clinical manifestations, management, and prognostic characteristics in 17 Chinese patients. Methods: Medical records and biopsies of 17 patients who had been treated at a large university hospital in China between March 2005 and January 2012 were reviewed. Results: Of the 17 patients, 14 were men. They had lesions on the scrotum and the penis. Of the three women, two had vulvar and one had inguinal lesions. All patients underwent Mohs micrographic surgery (MMS). Three men had metastasis to the inguinal lymph nodes and underwent an extensive local excision with inguinal lymphadenectomy. Eight patients who had positive excision margins received additional radiation therapy. The mean follow-up duration was 54 months (4-85 months). One patient had two recurrences. Three had metastasis to the inguinal lymph node. One had metastasis to the bone and concomitant prostate cancer. Two patients died of the disease. Conclusion: A striking difference in presentation of EMPD in Chinese compared with Caucasians is the male predominance and location on the penis and scrotum. Mohs micrographic surgery followed by radiotherapy is an effective treatment. Long-term follow-up suggests that the disease has a good prognosis when it does not metastasise.


Subject(s)
Adult , Aged , Asian Continental Ancestry Group , Combined Modality Therapy , Female , Follow-Up Studies , Genital Neoplasms, Female/pathology , Genital Neoplasms, Female/radiotherapy , Genital Neoplasms, Female/surgery , Genital Neoplasms, Male/pathology , Genital Neoplasms, Male/radiotherapy , Genital Neoplasms, Male/surgery , Humans , Lymph Node Excision , Male , Middle Aged , Mohs Surgery , Paget Disease, Extramammary/pathology , Paget Disease, Extramammary/radiotherapy , Paget Disease, Extramammary/surgery , Penis/pathology , Penis/surgery , Prognosis , Scrotum/pathology , Scrotum/surgery , Treatment Outcome , Vulva/pathology , Vulva/surgery
16.
Article in English | IMSEAR | ID: sea-157574

ABSTRACT

Genitourinary tumors may show varied clinical presentation and frequency in different regions of the world. The present study was therefore conducted to analyze the frequency, clinical presentation and the histopathological types of the various male genitourinary tumors diagnosed over a period of 14 years in a major teaching institute of north Himalayan region of India. Material and Methods: Retrospective study was undertaken in the Pathology department of the Institute which included all the cases of male genitourinary tumors which were diagnosed on histopathology from the time period between 1 Jan 1997 till 31st Dec. 2010. Results: The study showed that prostate was the most common site for male genitourinary tumors with prostatic adenocarcinoma as the most common histopathological type of tumor. Testicular Non- Hodgkin’s lymphoma constituted about 8% of total tumors in testes which mostly presented in elderly age group. Renal cell carcinoma (66.2%) was the most common tumor in kidney with much lower frequency of Wilm’s tumor (16.9%). Occasional rare tumors such as hemangioma of urinary bladder and schwannoma of penis were also seen over 14 years. Conclusion: The study concludes clinically patients were associated with more severe symptoms as they presented late to the hospital from the remote areas of this Himalayan region leading to late detection of tumors. Prostatic adenocarcinoma was the most common tumor while renal cell carcinoma was most common tumor in kidney. The present study provides valuable information to clinicians and pathologists regarding frequency, clinical presentation and histopathological types of male genitourinary tumors in this region which can be further used to formulate strategies for better management of these tumors.


Subject(s)
Adenocarcinoma/epidemiology , Adenocarcinoma/pathology , Adenocarcinoma/therapy , Adult , Aged , Carcinoma, Renal Cell/epidemiology , Carcinoma, Renal Cell/pathology , Carcinoma, Renal Cell/therapy , Genital Neoplasms, Male/epidemiology , Genital Neoplasms, Male/pathology , Genital Neoplasms, Male/therapy , Humans , India/epidemiology , Male , Middle Aged , Prostatic Neoplasms/epidemiology , Prostatic Neoplasms/pathology , Prostatic Neoplasms/therapy , Urogenital Neoplasms/epidemiology , Urogenital Neoplasms/pathology , Urogenital Neoplasms/therapy
17.
West Indian med. j ; 62(9): 859-860, Dec. 2013. ilus
Article in English | LILACS | ID: biblio-1045771

ABSTRACT

Metastatic tumour of spermatic cords, epididymis and seminiferous duct from gastric carcinoma has been recently reported but rarely seen. A case of metastatic tumour from gastric carcinoma in a 50-year old man is herein reported. The initial diagnosis was thickening of both spermatic cords. Needle biopsy of the spermatic cord, testicle and epididymis was performed. Pathological findings showed a gastric signet ring cell carcinoma. Thus, double radical orchiectomy was performed and metastatic signet ring cell carcinoma of the spermatic cord and testis was diagnosed through histological examination and immunohistochemistry. Physicians should be aware that gastric carcinoma is one of the possibilities for metastasis to the seminal duct.


El tumor metastásico de los cordones espermáticos, el epidídimo y el conducto seminífero a partir de un carcinoma gástrico ha sido reportado recientemente, pero pocas veces visto. En este trabajo se reporta el caso de un tumor metastásico a partir de un carcinoma gástrico en un hombre de 50 año de edad. El diagnóstico inicial fue el engrosamiento de los dos cordones espermáticos. Se realizó una biopsia con aguja del cordón espermático, testículos y epidídimo. Los resultados patológicos mostraron un carcinoma de células en anillo de sello. Por consiguiente, se realizó una orquiectomía radical doble, y el carcinoma metastásico en anillo de sello del cordón espermático y el testículo, fue diagnosticado mediante examen histológico e inmunohistoquímico. Los médicos deben tener presente que el carcinoma gástrico es una de las posibilidades de metástasis en los conductos seminales.


Subject(s)
Humans , Middle Aged , Spermatic Cord/pathology , Stomach Neoplasms/pathology , Carcinoma/pathology , Genital Neoplasms, Male/secondary , Biopsy, Needle , Orchiectomy , Genital Neoplasms, Male/surgery , Genital Neoplasms, Male/diagnosis
18.
National Journal of Andrology ; (12): 714-718, 2013.
Article in Chinese | WPRIM | ID: wpr-350831

ABSTRACT

<p><b>OBJECTIVE</b>To systematically study the clinical diagnosis and treatment of smooth muscle tumor in the male reproductive system.</p><p><b>METHODS</b>We analyzed the ultrasonographic features, pathological findings, treatment strategies and postoperative follow-up results of 5 male patients with smooth muscle tumor in the reproductive system, and reviewed other relevant literature.</p><p><b>RESULTS</b>Compared with leiomyoma, leiomyosarcoma exhibited stronger mixed echoes than the testis at ultrasonography, typical mitotic phase (> or = 2/10 HP) of tumor cells at HE staining, and significant expressions of HIF-1alpha and Glut-1 at immunohistochemistry. No relapse was observed in the 2 cases of leiomyoma during the 10-year follow-up after simple tumor resection, nor were recurrence and metastasis in another 3 cases of leiomyosarcoma during the first year after radical surgery without combined radio- and chemo-therapy.</p><p><b>CONCLUSION</b>Primary smooth muscle tumor of the male reproductive system is difficult to be diagnosed. Ultrasonography can help to preliminarily screen leiomyosarcoma. For those with possible leiomyosarcoma, preoperative MRI and intraoperative frozen sectioning examinations are recommended for the possibility of lymphatic metastasis. Postoperative radiotherapy and chemotherapy should be chosen cautiously for those confirmed with leiomyosarcoma by pathological examination.</p>


Subject(s)
Adult , Genital Neoplasms, Male , Diagnosis , Therapeutics , Humans , Male , Middle Aged , Retrospective Studies , Smooth Muscle Tumor , Diagnosis , Therapeutics
19.
KMJ-Kuwait Medical Journal. 2013; 45 (1): 63-65
in English | IMEMR | ID: emr-171951

ABSTRACT

Tumors of the epididymis, whether benign or malignant, primary or secondary are very rare. Adenomatoid tumors and leiomyomas are the most frequently diagnosed benign tumors of the epididymis. We report a case of a left-sided asymptomatic leiomyoma of the epididymis in a 39-year-old Asian man who presented with an inguinal hernia on the right side. Ultrasonography was suggestive of adenomatoid tumor of the epididymis. Surgical exploration was done through an inguinal incision with conservative excision of the benign looking mass of the tail of the epididymis. Frozen section was not performed because of clinical suspicion of tuberculosis. Histopathological examination revealed an epididymal leiomyoma. Herein, we report this case and review the relevant literature


Subject(s)
Adult , Humans , Male , Epididymis/pathology , Genital Neoplasms, Male , Review Literature as Topic , Hernia, Inguinal , Ultrasonography
20.
Urology Annals. 2013; 5 (1): 53-55
in English | IMEMR | ID: emr-146886

ABSTRACT

Malignant tumors of the spermatic cord are rare. There are a few case reports on spermatic cord metastasis from colonic, gastric, pancreas, and prostatic cancer. Here, we report a 36-year-old man with brucellosis presenting with spermatic cord metastasis as early manifestation of small bowel adenocarcinoma


Subject(s)
Humans , Male , Spermatic Cord , Genital Neoplasms, Male/secondary , Colonic Neoplasms/pathology , Neoplasm Metastasis , Adenocarcinoma , Intestine, Small
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