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1.
Rev. colomb. cardiol ; 28(2): 119-127, mar.-abr. 2021. tab, graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1341273

ABSTRACT

Resumen Introducción:: El índice leucoglucémico es un factor pronóstico, poco conocido y utilizado, que relaciona la glucemia y los leucocitos registrados al ingreso hospitalario. Su importancia radica en la determinación del riesgo de complicaciones y la mortalidad en pacientes con infarto agudo de miocardio. Objetivo: Establecer al índice leucoglucémico como factor predictor de complicaciones durante la evolución intrahospitalaria en los pacientes con infarto agudo de miocardio. Método: Estudio de tipo epidemiológico, analítico, observacional y de corte transversal, en una cohorte de pacientes que ingresaron con infarto agudo de miocardio durante un período de un año y tres meses. Resultados: Se incluyó en el estudio a 205 pacientes con infarto agudo de miocardio, cuyo promedio de edad fue de 62.99 ± 12.2 años, con predominio en varones con 69.3%. El infarto agudo de miocardio con elevación del segmento ST predominó en frecuencia con 63.9% y mayor tasa de complicaciones (p < 0.001). El promedio del índice leucoglucémico fue de 1,578.41 ± 1,208.1 y el punto de corte establecido fue de 656.8, de acuerdo con la curva ROC, con sensibilidad del 95.8% y especificidad del 73% para la predicción de complicaciones intrahospitalarias, con OR de 7.89. Conclusión: Un índice leucoglucémico > 656.8 representa un riesgo de 7.89 veces de desarrollar complicaciones en la población estudiada.


Abstract Introduction: Leukoglycemic index is a poorly known and used prognostic factor that correlates blood glucose and leukocytes which are taken at hospital admission. Its importance lies in determining complications and mortality risks in patients with acute myocardial infarction. Objective: To establish the leukoglycemic index as a predictor of complications during the in-hospital evolution in patients with acute myocardial infarction. Methods: Epidemiological, observational, cross-sectional, crosssectional study on a cohort of patients admitted with acute myocardial infarction during a period of 1 year 3 months. Results: 205 patients with acute myocardial infarction were included in this study. The mean age was 62.99 ± 12.2 years old, more frequently in males by 69.3%. It was determined that acute myocardial infarction with ST elevation predominated both in frequency with 63.9%, as well as with a higher rate of complications (p < 0.001). The average of leukoglycemic index was 1578.41 ± 1208.1 and the cut-off point was 656.8, according to ROC curve, with sensitivity of 95.8% and specificity of 73% for the prediction of inhospital complications, OR 7.89. Conclusions: A leukoglycemic index greater than 656.8 represents a 7.89-fold risk of developing complications in the study population.


Subject(s)
Humans , Male , Female , Middle Aged , Myocardial Infarction , Prognosis , Mortality , Sensitivity and Specificity , Glycemic Index
2.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 11-17, Jan.-Feb. 2021. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1153045

ABSTRACT

Ketosis can seriously impair cow performance. This study detected changes in prepartum blood metabolic parameters for predicting postpartum ketosis occurrence in dairy cows. Body condition score (BCS) was assessed before and after delivery. Blood samples of 63 cows were collected from 10 days before calving to 10 days after calving to measure metabolic parameters including ß-hydroxybutyric acid (BHBA), non-esterified fatty acid (NEFA), glucose (GLU), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total protein (TP), albumin (ALB), globulin (GLO), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). There was a postpartum subclinical ketosis incidence of 42.25%. Compared with prepartum, plasma, levels of BHBA, AST, and NEFA significantly increased postpartum, and prepartum AST (R=0.57) and NEFA (R=0.45) showed a significant positive correlation with ketosis postpartum. Plasma GLU level significantly decreased postpartum and was significantly negatively correlated with ketosis (R=-0.21). Receiver operating characteristic curve analysis revealed prepartum BSC < 2.88, and prepartum plasma AST > 68.0 U/L, GLU < 3.97mmol/L, NEFA > 0.27mmol/L, and BHBA > 0.43mmol/L, indicating a high risk of subclinical ketosis postpartum. These levels can be used as risk indicators to predict the occurrence of subclinical ketosis in postpartum cows.(AU)


A cetose pode trazer sérios prejuízos ao desempenho da vaca. Este estudo detectou alterações nos parâmetros metabólicos do sangue pré-parto para prever a cetose pós-parto que ocorre em vacas leiteiras. O escore de condição corporal (ECC) foi avaliado antes e após o parto. Foram coletadas amostras de sangue de 63 vacas entre 10 dias antes e 10 dias após o parto para medir os parâmetros metabólicos, incluindo ácido ß-hidroxibutírico (BHBA), ácido graxo não esterificado (NEFA), glicose (GLU), bilirrubina total (TBIL), bilirrubina direta (DBIL), bilirrubina indireta (IBIL), proteína total (TP), albumina (ALB), globulina (GLO), alanina aminotransferase (ALT) e aspartato aminotransferase (AST). Houve uma incidência de cetose subclínica pós-parto de 42,25%. Em comparação com o pré-parto, o plasma, os níveis de BHBA, AST e NEFA aumentaram significativamente no pós-parto, e AST no pré-parto (R = 0,57) e NEFA (R = 0,45) mostraram uma correlação significativa positiva com cetose pós-parto. O nível plasmático de GLU diminuiu significativamente no pós-parto e foi negativamente correlacionado com a cetose de forma significativa (R = -0,21). A análise da curva característica de operação do receptor revelou BSC pré-parto <2,88 e AST plasmático pré-parto> 68,0 U / L, GLU <3,97mmol / L, NEFA> 0,27mmol / L e BHBA> 0,43mmol / L, indicando um alto risco de cetose subclínica pós-parto. Esses níveis podem ser usados ​​como indicadores de risco para prever a ocorrência de cetose subclínica em vacas no pós-parto.(AU)


Subject(s)
Animals , Female , Cattle , Plasma Volume/veterinary , Peripartum Period/metabolism , Ketosis/blood , Ketosis/veterinary , Glycemic Index
3.
Article in English | WPRIM | ID: wpr-878316

ABSTRACT

Objective@#The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.@*Methods@#The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.@*Results@#A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).@*Conclusion@#An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women.


Subject(s)
Aged , Asian Continental Ancestry Group , Blood Glucose/analysis , China/epidemiology , Cohort Studies , Diabetes Mellitus/blood , Female , Glucose Tolerance Test , Glycated Hemoglobin A/analysis , Glycemic Index , Humans , Male , Middle Aged , Uric Acid/blood
4.
Article in Spanish | LILACS | ID: biblio-1352782

ABSTRACT

RESUMEN: Objetivo: Analizar el efecto de un programa de Entrenamiento MultiComponente (EMC) sobre autonomía funcional, fuerza muscular, composición corporal, capacidad cognitiva y perfil glucémico de mujeres mayores. Material y Métodos: 13 mujeres con edad 61,0 ± 6,0 años, participaron del estudio durante 12 semanas, siendo ­ Entrenamiento Resistido (ER); martes y viernes ­ Entrenamiento Funcional (EF) y Entrenamiento de Judo Adaptado (EJA), en la misma sesión; se utilizó el protocolo de autonomía funcional ­ GDLAM, Mini Examen del Estado Mental (MEEM), test de predicción de 1RM, índices: glicémico, masa corporal (IMC), relación cintura-cadera (IRCQ), relación cintura-estatura (RCE) y siete pliegues cutáneos. Resultados:Hubo mejora (p<0,05) para todos los test del GDLAM y el índice general (∆% = -21,31%; p-valor = 0,0006). Para el MEEM fue identificado mejoría en el puntaje general (∆%=8,98%; p-valor= 0,002), atención, cálculo y lenguaje. También hubo mejora (p<0,05) para todos los ejercicios de fuerza. Para composición corporal: porcentaje de grasa (%G) (∆%= -11,8%; p-valor= 0,001). Conclusión: El programa de EMC realizado cuatro veces en la semana, durante 12 semanas fue eficaz para mejorar la autonomía funcional, la fuerza muscular, la función cognitiva, para variables % G, masa magra y grasa de las mujeres estudiadas.


BSTRACT: Objective: To analyze the effect of a Multi-Component Training (CMT) program on functional autonomy, muscle strength, body composition, cognitive capacity and glycemic profile of older women. Material and Methods: 13 women aged 61.0 ± 6.0 years, participated in the study for 12 weeks, being -Resisted Training (ER); Tuesday and Friday - Functional Training (EF) and Adapted Judo Training (EJA), in the same session; The functional autonomy protocol was used - GDLAM, Mini Mental State Examination (MMSE), 1RM prediction test, glycemic index, body mass (BMI), waist-hip ratio (WHR), waist-height ratio (WHtR) and seven skin folds. Results:There was improvement (p <0.05) for all GDLAM tests and the general index (Δ% = -21.31%; p-value = 0.0006). For the MMSE, an improvement was identified in the general score (Δ% = 8.98%; p-value = 0.002), attention, calculation and language. There was also improvement (p <0.05) for all resistance exercises. For body composition: fat percentage (% G) (Δ% = -11.8%; p-value = 0.001). Conclusion:The CME program performed four times a week for 12 weeks was effective in improving functional autonomy, muscle strength, cognitive function, for variables % F, lean mass and fat of the women studied.


Subject(s)
Humans , Female , Middle Aged , Aged , Physical Education and Training/methods , Exercise , Health , Mental Health , Cognition , Skinfold Thickness , Health Programs and Plans , Blood Glucose/analysis , Body Composition , Activities of Daily Living , Glycemic Index , Muscle Strength
5.
Rev. Nutr. (Online) ; 34: e190174, 2021. tab, graf
Article in English | LILACS | ID: biblio-1155460

ABSTRACT

ABSTRACT Objective The natural probiotic kefir is fermented milk, and may have effects on satiety and voluntary energy intake. This randomized crossover trial aimed to determine whether kefir, consumed with low- or high-glycemic index meals, affects appetite and subsequent food intake. Methods Twenty four healthy females aged 21-24 years, were recruited from Erciyes University and the surrounding community. The participants were submitted to three different breakfasts: a low glycemic index accompanied by milk, a low glycemic index with kefir, and a high glycemic index with kefir, with a 1-week washout period between meals. At 0, 15, 30, 60, 90, 120, 150, and 180 minutes after the meal, appetite ratings were measured by the visual analog scale, and then ad libitum lunch was served. Results No differences in appetite scores and voluntary energy intake were detected between the test meals. Furthermore, palatability ratings were similar between test meals, except for the higher score of high glycemic index kefir for overall palatability. Conclusion This study demonstrated that adding kefir to a high glycemic index meal may prevent increases in appetite and food intake, resulting in postprandial responses similar to those of a low glycemic index meal. These findings might enable the development of novel dietary strategies based on appetite regulation to treat or prevent obesity, particularly for Western societies. This trial was registered at ClinicalTrials.gov under the process NCT03636217.


RESUMO Objetivo O quefir probiótico natural é um leite fermentado, e pode ter alguns efeitos sobre a saciedade e a ingestão voluntária de energia. Este ensaio cruzado randomizado teve como objetivo determinar se o quefir consumido com uma refeição de baixo ou alto índice glicêmico teria afetado o apetite e a ingestão de alimentos subsequente. Métodos Vinte e quatro mulheres saudáveis, com idades entre 21 e 24 anos, foram recrutadas na Universidade de Erciyes e na comunidade circundante. Todas as participantes foram submetidas a três cafés da manhã diferentes: um baixo índice glicêmico e leite, um baixo índice glicêmico e quefir, e um alto índice glicêmico e quefir, com um período de lavagem de 1 semana entre as refeições. Aos 0, 15, 30, 60, 90, 120, 150 e 180 minutos após a refeição, as classificações de apetite foram medidas por escala analógica visual e, em seguida, o almoço ad libitum foi servido. Resultados Não foram detectadas diferenças nos escores do apetite e na ingestão voluntária de energia entre as refeições do teste. Além disso, as classificações de palatabilidade foram semelhantes entre as refeições de teste, exceto o maior escore de alto índice glicêmico quefir para palatabilidade geral. Conclusão Este estudo demonstrou que a adição de quefir a uma refeição com alto teor de índice glicêmico pode impedir o aumento do apetite e da ingestão de alimentos, resultando em respostas pós-prandiais semelhantes a uma refeição com baixo teor de índice glicêmico. Esses achados poderiam permitir o desenvolvimento de novas estratégias dietéticas baseadas na regulação do apetite para tratar ou prevenir a obesidade, particularmente para a sociedade ocidental. Esse julgamento foi registado na ClinicalTrials.gov como NCT03636217.


Subject(s)
Humans , Female , Adult , Appetite , Eating , Kefir , Probiotics , Glycemic Index
6.
Rev. cuba. salud pública ; 46(4): e1827, oct.-dic. 2020. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1156620

ABSTRACT

Introducción: Durante el ciclo de vida de los individuos son imprescindibles intervenciones para detectar y reducir el riesgo y las complicaciones de las enfermedades crónicas. Objetivo: Determinar la prevalencia de valores de riesgo vascular de los principales indicadores del metabolismo glucídico y lipídico en adolescentes y ancianos de La Habana. Métodos: Se realizó un estudio transversal en una muestra conformada por adolescentes (469 de 12-16 años) aparentemente sanos y ancianos (395 de 65-100 años) sin diagnóstico de enfermedades asociadas a la alteración marcada del estado nutricional y metabólico. Ambas poblaciones fueron evaluadas para glucosa, triglicéridos, colesterol total, colesterol de lipoproteinas de alta densidad y colesterol de lipoproteínas de baja densidad, séricos, mediante métodos enzimáticos convencionales. Se usaron rangos de riesgo referentes. Los resultados se analizaron mediante estadística descriptiva. Resultados: En los adolescentes evaluados, los triglicéridos (35,6 por ciento) y el colesterol total (23,9 por ciento) mostraron las mayores frecuencias de valores de riesgo. En las hembras ambos marcadores se mantuvieron como los más elevados en ese orden, mientras que, en los varones, la glucosa (25,5 por ciento) secundó a los triglicéridos como indicadores más alterados. En ancianos, al colesterol de lipoproteínas de baja densidad (58,2 por ciento) y al colesterol total (48,6 por ciento) correspondieron las mayores frecuencias de cifras de riesgo, patrón que se repitió en cada sexo. Los valores promedio de los indicadores fueron marcadamente superiores en ancianos que, en adolescentes, excepto para glucosa y colesterol de lipoproteínas de alta densidad. Conclusiones: Los resultados obtenidos muestran una elevada prevalencia de valores de riesgo vascular de varios indicadores metabólicos evaluados en adolescentes y ancianos, lo que sugiere la necesidad de monitorear los indicadores analizados e implementar intervenciones modificadoras de sus valores hacia la reducción del riesgo asociado, desde etapas tempranas, como las previas a la adolescencia(AU)


Introduction: During the life cycle of individuals, interventions are essential to detect and reduce the risk and complications of chronic diseases. Objective: To determine the prevalence of vascular risk values of the main indicators of carbohydrate and lipid metabolism in adolescents and elderlies in Havana. Methods: A cross-sectional study was carried out with a sample made up of apparently healthy adolescents (469; aged 12-16 years) and elderlies (395 aged 65-100 years) without a diagnosis of diseases associated with marked alteration of nutritional and metabolic status. Both populations were evaluated regarding serum glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol using conventional enzymatic methods. Reference risk ranges were used. The results were analyzed using descriptive statistics. Results: In the evaluated adolescents, triglycerides (35.6 percent) and total cholesterol (23.9 percent) showed the highest frequencies of risk values. In females, both markers remained the highest in that aspect; while in males, glucose (25.5 percent) accounted second after triglycerides as the most altered indicators. In the elderlies, low-density lipoprotein cholesterol (58.2 percent) and total cholesterol (48.6 percent) corresponded to the highest frequencies of risk values, a pattern that was repeated in each sex. The average values of the indicators were markedly higher in the elderlies than in adolescents, except for glucose and high-density lipoprotein cholesterol. Conclusions: The results obtained show high prevalence of vascular risk values of several metabolic indicators evaluated in adolescents and elderlies, which suggests the need to monitor the analyzed indicators and implement interventions to modify such values, in view of reducing the associated risk, from stages early, such as the pre-adolescence stage(AU)


Subject(s)
Humans , Male , Female , Adolescent , Aged , Vascular Diseases/epidemiology , Clinical Laboratory Techniques/methods , Glycemic Index , Hyperlipidemias/drug therapy , Cross-Sectional Studies
7.
Rev. bras. anal. clin ; 52(4): 359-365, 20201230. tab, graf
Article in Portuguese | LILACS | ID: biblio-1223708

ABSTRACT

Objetivo: Avaliar a correlação entre os níveis de hemoglobina glicada A1c (HbA1c) e os valores de microalbuminúria como parâmetro auxiliar no diagnóstico precoce de dano renal. Métodos: Analisaram-se 56 pacientes que apresentaram os exames de glicemia de jejum, HbA1c e microalbuminúria, durante o período de um ano em um laboratório do município de Videira-SC. A análise dos dados foi realizada pelo teste de correlação de Pearson's estabelecendo como valores estatisticamente significativos p < 0,05. Resultados: Os valores de glicose de jejum se apresentaram alterados em ambos os sexos e faixa etária. Na hemoglobina glicada indivíduos do sexo feminino com faixa etária de até 60 anos de idade demostraram maiores alterações no controle glicêmico. Para os resultados de micro­albuminúria, 68% dos participantes apresentaram valores normais e 32% exibiram valores acima dos de referência, indicando presença de microalbuminúria e possível dano renal. Os valores mostraram correlação entre microalbuminúria e HbA1c em mulheres e homens respectivamente (p < 0,0001). Conclusão: Quando os valores de HbA1c apresentaram-se aumentados consequentemente os valores de microalbuminúria também estavam elevados. Portanto, a utilização desses marcadores na busca de identificar danos renais é fundamental.


Objective:This study aimed to evaluate the correlation between the levels of glycated hemoglobin A1c (HbA1c) and the values of microalbuminuria as an auxiliary parameter in the early diagnosis of kidney damage. Methods: Fifty-six patients who had fasting blood glucose, HbA1c and microalbuminuria tests were analyzed during a period of one year in a laboratory in the municipality of Videira-SC. Data analysis was performed using Pearson's correlation test, establishing as statistically significant values p < 0.05. Results: Fasting glucose values were altered in both sexes and age groups. In glycated hemoglobin, female individuals aged up to 60 years old showed greater changes in glycemic control. For the results of microalbuminuria, 68% of the participants had normal values and 32% showed values above those of reference, indicating the presence of microalbuminuria and possible kidney damage. The values showed a correlation between microalbuminuria and HbA1c in women and men respectively (p <0.0001). Conclusion: When the HbA1c values were consequently increased, the microalbuminuria values were also high. Therefore, the use of these markers in the search to identify kidney damage is essential.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Glycated Hemoglobin A , Glycemic Index , Diabetes Mellitus , Albuminuria
8.
Rev. cuba. invest. bioméd ; 39(2): e569, abr.-jun. 2020. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1126588

ABSTRACT

Introducción: El Entrenamiento Interválico de Alta Intensidad durante los últimos años ha sido postulado como tratamiento no farmacológico para enfermedades como la diabetes tipo II en diferentes poblaciones, sin embargo, son pocos los estudios que se han realizado en adultos mayores. Objetivo: Determinar el efecto agudo de una sesión de Entrenamiento Interválico de Alta Intensidad sobre los niveles de glucosa en adultos mayores físicamente activos. Métodos: Se realizó un estudio experimental. La muestra estuvo conformada por 19 adultos mayores (60-85 años). El grupo fue sometido a una sesión de Entrenamiento Interválico de Alta Intensidad, en la que se combinaron ejercicios de fuerza con resistencia cardiovascular, y se realizaron 12 ejercicios con duración de 30 segundos de trabajo por 10 de descanso. La intensidad de la sesión fue controlada a través de la Escala de Percepción del Esfuerzo OMNI-GSE. Se midió la talla (cm), el peso (kg) e índice de masa corporal. Los niveles de glucosa en sangre fueron determinados antes y después de la sesión. Resultados: Se obtuvo una disminución significativa en los niveles de glucosa en sangre posterior a la realización de la sesión de Entrenamiento Interválico de Alta Intensidad (pre: 140,5 mg/dL y post: 116,1 mg/dL; p < 0,01) Conclusiones: El Entrenamiento Interválico de Alta Intensidad reduce en una sola sesión los niveles de glucosa en sangre en adultos mayores(AU)


Introduction: in recent years, High-Intensity Interval Training has been recognized as a non-pharmacological treatment for diseases like type II diabetes in a variety of populations. However, few studies about this topic have been conducted with elderly people. Objective: determine the acute effect of a High-Intensity Interval Training session on glucose levels in physically active elderly people. Methods: an experimental study was conducted. The sample was 19 elderly people aged 60-85 years. The group participated in a High-Intensity Interval Training session in which strength and cardiovascular resistance exercises were combined. The 12 exercises performed had a duration of 30 seconds' work and 10 seconds' rest. The intensity of the session was controlled with the OMNI-GSE Effort Perception Scale. Measurements were taken of the height (cm), weight (kg) and body mass index of participants. Blood glucose levels were gauged before and after the session. Results: a significant reduction in blood glucose levels was obtained after the conduct of the High-Intensity Interval Training session (pre: 140.5 mg/dl and post: 116.1 mg/dl; p < 0.01). Conclusions: in only one session, High-Intensity Interval Training reduces blood glucose levels in elderly people(AU)


Subject(s)
Humans , Aged , Aged, 80 and over , Body Mass Index , High-Intensity Interval Training/methods , Measurements, Methods and Theories , Epidemiology, Experimental , Glycemic Index/physiology , Diabetes Mellitus, Type 2/therapy
9.
Rev. cuba. med ; 59(1): e1327, ene.-mar. 2020. tab, graf
Article in Spanish | LILACS, CUMED | ID: biblio-1139038

ABSTRACT

Introducción: El índice glucemia-triglicéridos se utiliza para el diagnóstico presuntivo de la resistencia insulínica, que en los pacientes hipertensos se relaciona con la severidad de la hipertensión arterial. Objetivo: Determinar la utilidad del índice glucemia-triglicéridos como marcador de resistencia a la insulina en pacientes adultos con diagnóstico de hipertensión arterial esencial. Métodos: Se realizó un estudio descriptivo transversal en 232 pacientes con diagnóstico de hipertensión arterial esencial. Se calculó el índice glucemia-triglicéridos y se comparó con el índice HOMA. Para este análisis se utilizó la curva ROC, la correlación de Pearson y el Índice de Kappa, se consideró significativo un valor de p menor a 0,05. Resultados: Se obtuvo un punto de corte de 8,1 que mostró una sensibilidad de 98,6 con una especificidad de 41,4. La curva ROC mostró un área bajo la curva con valor de 0,694 ≈ 0,7. Se observó correlación positiva (p=0,008) Índice de Kappa=88,4 por ciento. Conclusiones: El índice glucemia-triglicéridos resulto ser útil en pacientes con hipertensión arterial como marcador de resistencia a la insulina con un punto de corte de 8,1(AU)


Introduction: The glycemia-triglyceride index is used for the presumptive diagnosis of insulin resistance, which in hypertensive patients is related to the severity of high blood pressure. Objective: To determine the utility of the glycemia-triglyceride index as a marker of insulin resistance in adult patients diagnosed with essential arterial hypertension. Methods: A descriptive cross-sectional study was carried out in 232 patients diagnosed with essential arterial hypertension. The glycemia-triglyceride index was calculated and compared with HOMA index. For this analysis, ROC curve, Pearson correlation and Kappa index were used, p value less than 0.05 was considered significant. Results: We obtained an 8.1 cut-off point, showing 98.6 sensitivity and 41.4 specificity. The area below the ROC curve showed 0.694 ≈ 0.7 value. Positive correlation was observed (p = 0.008). Kappa index = 88.4 percent. Conclusions: The glycemia-triglyceride index turned out to be useful in patients with essential hypertension as a marker of insulin resistance with a cut-off point of 8.1(AU)


Subject(s)
Humans , Male , Female , Insulin Resistance/physiology , Glycemic Index/physiology , Essential Hypertension/diagnosis , Epidemiology, Descriptive , Cross-Sectional Studies
10.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 29(4,Supl): 432-440, out.-dez. 2019. tab, graf
Article in Portuguese | LILACS | ID: biblio-1047350

ABSTRACT

O diabetes mellitus tipo 2 (DM2) é considerado um dos principais distúrbios metabólicos relacionados ao desenvolvimento de doenças cardiovasculares e outras comorbidades, com elevada incidência e prevalência no Brasil e no mundo. Apesar dos avanços em seu tratamento, a projeção mundial é de aumento no número de diagnósticos. No Brasil, o total de pessoas com a doença cresceu mais de 60% em 10 anos. Como o manejo dietético é um dos pilares no tratamento do DM2, este trabalho objetivou analisar os estudos que compararam as dietas restritas em carboidratos com outras abordagens dietéticas a fim de elucidar se esta seria a opção mais adequada para os pacientes com DM2. Assim, fez-se uma revisão de ensaios clínicos randomizados por meio das plataformas de pesquisa PubMed e Cochrane Library em outubro de 2018, selecionando os estudos segundo a estratégia PICO de pesquisa. Dos 398 artigos encontrados, 19 atenderam os critérios de elegibilidade. Após a análise, demonstrou-se que as dietas restritas em carboidratos favorecem o controle glicêmico, melhora do perfil lipídico e redução dos medicamentos para DM2 em relação às outras opções dietéticas, no entanto, os trabalhos apresentam vieses metodológicos e são, em geral, de curto prazo. Sendo assim, é precipitado afirmar que essas dietas são mais efetivas para o tratamento do DM


Type 2 diabetes mellitus (T2DM) is considered one of the primary metabolic disorders related to the development of cardiovascular diseases and other comorbidities, with high incidence and prevalence in Brazil and in the world. Despite advances in its treatment, an increase in the number of diagnoses is estimated worldwide. In Brazil, the total number of people with the disease has grown more than 60% in 10 years. As dietary management is one of the mainstays in the treatment of T2DM, this study aimed to analyze the studies that compared carbohydrate-restricted diets with other dietary approaches to elucidate if this would be the most appropriate option for patients with T2DM. Thus, randomized clinical trials were reviewed through the PubMed and Cochrane Library research platforms in October 2018, selecting the studies according to the PICO research strategy. Of the 398 articles found, 19 met the eligibility criteria and had their data collected. After the analysis, it was demonstrated that carbohydrate-restricted diets support glycemic control, loss of body mass, improvement of lipid profile and reduction of medications for T2DM compared to other dietary options. However, a significant part of the studies has methodological biases and is generally short-term. Therefore, the level of evidence supporting dietary restriction of carbohydrates in the management of T2DM is considered moderate. Thus, according to the principle of the null hypothesis, it is unwise to affirm that these diets are superior in the treatment of DM2


Subject(s)
Carbohydrates , Diabetes Mellitus/therapy , Diet, Carbohydrate-Restricted , Cardiovascular Diseases , Body Mass Index , Risk Factors , Glycemic Index , Diet , Obesity
12.
Rev. cuba. med ; 58(3): e1317, jul.-set. 2019. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1139018

ABSTRACT

Introducción: La esteatosis hepática no alcohólica es la enfermedad con mayor frecuencia en el mundo, esta se asocia a diabetes mellitus tipo 2; padecimiento con gran impacto económico-social. Objetivo: Describir el comportamiento de esteatosis hepática en una población de pacientes con diagnóstico de diabetes mellitus tipo 2. Métodos: Se realizó un estudio observacional, descriptivo, transversal en 94 pacientes diabéticos atendidos en el Hospital Clínico Quirúrgico Hermanos Ameijeiras, en el periodo comprendido entre febrero 2016- febrero 2018. Resultados: La esteatosis fue leve en 42,6 por ciento, moderada (44,7 por ciento) y severa en 12,8 por ciento, en ambos casos, con un NAFLD score principalmente indeterminado (72,3 por ciento). Se detectó fibrosis F0-1 en 58,5 por ciento de los pacientes, F2 (29,8 por ciento) y significativa (F3 y F4) en 11,7 por ciento). Se detectó asociación entre ecogenicidad hepática aumentada, patrón hepático difuso y grado severo de esteatosis por ecografía con mayor grado de fibrosis según elastografía. Se detectó relación significativa de niveles elevados de HBA1C con fibrosis significativa medida tanto por NAFLD score como por elastografía. Conclusiones: La esteatosis hepática presente en los pacientes con diabetes mellitus fue principalmente leve a moderada con prevalencia de fibrosis leve, el grado de fibrosis significativa se asoció con ecogenicidad hepática aumentada, patrón hepático difuso, grado severo de esteatosis por ecografía y niveles elevados de hemoglobina glucosilada(AU)


Introduction: Non-alcoholic liver steatosis is the most frequent disease in the world. It is associated with type 2 diabetes mellitus, representing great economic-social impact. Objective: To describe the behavior of hepatic steatosis in a population of patients diagnosed with type 2 diabetes mellitus. Methods: An observational, descriptive, cross-sectional study was conducted in 94 diabetic patients treated at Hermanos Ameijeiras Clinical Surgical Hospital, from February 2016 to February 2018. Results: Steatosis was mild in 42.6 percent, moderate (44.7 percent) and severe in 12.8 percent, with a mainly indeterminate NAFLD score (72.3 percent). F0-1 fibrosis was detected in 58.5 percent of the patients, F2 (29.8 percent) and significant (F3 and F4) in 11.7 percent). Association between increased liver echogenicity, diffuse liver pattern and severe degree of steatosis were ostensible by ultrasound with higher degree of fibrosis according to elastography. Significant relationship of elevated levels of HBA1C with significant fibrosis was detected, measured both by NAFLD score and by elastography. Conclusions: Hepatic steatosis present in patients with diabetes mellitus was mainly mild to moderate with prevalence of mild fibrosis, the degree of significant fibrosis was associated with increased liver echogenicity, diffuse liver pattern, severe degree of steatosis by ultrasound and high levels of hemoglobin. glycosylated(AU)


Subject(s)
Humans , Male , Female , Middle Aged , Glycemic Index/physiology , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/diagnostic imaging , Epidemiology, Descriptive , Cross-Sectional Studies , Non-alcoholic Fatty Liver Disease/epidemiology
13.
Arch. latinoam. nutr ; 69(2): 80-88, jun. 2019. tab, graf
Article in English | LILACS, LIVECS | ID: biblio-1048668

ABSTRACT

as been proposed that the consumption of common beans (Phaseolus vulgaris L.) reduces cardiovascular risk, and prevents and controls both chronic and degenerative diseases. The aim of this study was to compare the antioxidant capacity of a bean-fiber fortified bar (BFB) versus a commercial bar (CB) in 60 Mexican men and women (18-65 years old), who were randomly distributed in two groups: BFB or CB; individuals consumed a bar a day for one month. Anthropometric data, food intake and blood samples were collected. Glucose tolerance (GTT), lipid profile (PL), and lipid peroxidation (TBARS) tests were performed; carbonyls groups in serum oxidized proteins were also measured. GTT and PL were not different between both groups in either the 15 or 30-day follow-up of bar consumption assessments. There were no significant differences in either TBARS or carbonyl concentration between groups; BFB group showed higher levels of serum lipid peroxidation in basal and fifteen days measurements; these levels decreased at the final evaluation: No differences were detected on carbonyl levels between groups. In conclusion, 30 days of fiber bean bar consumption did not alter glucose or PL levels, while, in the BFF group, oxidative stress decreased within 30 days of the consumption of the fortified bar(AU)


Se ha propuesto que el consumo de frijol común (Phaseolus vulgaris L.) reduce el riesgo cardiovascular, y previene y controla las enfermedades crónicas y degenerativas. El objetivo del presente estudio fue comparar la capacidad antioxidante de una barra fortificada con fibra de frijol (BFB) versus una barra comercial (CB) en 60 hombres y mujeres mexicanos (18-65 años de edad), quienes aleatoriamente fueron distribuidos en dos grupos: El grupo BFB y el CB que consumieron la barras fortificada con frijol y la barra comercial, respectivamente, durante un mes. Se recopilaron datos antropométricos, ingesta de alimentos y muestras de sangre. Se realizó prueba de tolerancia a la glucosa (GTT), el perfil de lípidos (PL), la peroxidación de lípidos (TBARS) y la cuantificación de carbonilos en proteínas oxidadas como pruebas de bioquímica sanguínea. GTT y PL no fueron diferentes entre ambos grupos en la evaluación de seguimiento de 15 y 30 días del consumo de la barra. No hubo diferencias significativas en los TBARS o la concentración de carbonilo entre los grupos, el grupo BFB mostró niveles más altos de peroxidación de lípidos en suero en la fase basal y a los quince días del consumo de la barra; curiosamente, estos niveles disminuyeron en la evaluación final. No se detectaron diferencias en los niveles de carbonilo entre los grupos. En conclusión, 30 días de consumo de barras de fibra de frijol no alteraron los niveles de glucosa o PL; mientras que, en el grupo BFB, el estrés oxidativo disminuyó a los 30 días del consumo de la barra fortificada(AU)


Subject(s)
Humans , Male , Female , Food, Fortified , Eating , Cholesterol , Chronic Disease , Fabaceae , Glycemic Index , Phenolic Compounds , Antioxidants
14.
Arq. bras. cardiol ; 112(5): 555-563, May 2019. tab, graf
Article in English | LILACS | ID: biblio-1011184

ABSTRACT

Abstract Background: The use of autonomic modulation as a predictor of cardiovascular risk in women with breast cancer is important. Objective: To evaluate the cardiac autonomic modulation of postmenopausal women using aromatase inhibitors for breast cancer treatment, as well as its relation with the following biochemical variables. Methods: Postmenopausal women who did not have breast cancer (n = 33) and postmenopausal women with breast cancer (n = 15). For evaluation of the autonomic modulation the heart rate was recorded beat-to-beat for 30 minutes and the series of RR intervals obtained were used to calculate the following heart rate variability indices: Mean RR ms, SDNN (standard deviation of all normal RR intervals, expressed in milliseconds) ms, Mean HR, RMSSD (square root of the mean of the squared differences between adjacent normal RR interval) ms, NN50 (number of pairs of successive NNs that differ by more than 50 ms) count, pNN50% (proportion of NN50 divided by total number of NNs), RRtri (RR triangular), TINN (triangular interpolation of NN interval) ms, SD1 ms, SD2 ms, LF ms2, HF ms2, LH/HF ms2. The values of biochemical variables (fasting glycemia, triglycerides, HDL-cholesterol, and C-reactive protein) were analyzed by blood sample. Results: Lower values of heart rate variability indices were observed in postmenopausal women with breast cancer in relation to postmenopausal women who did not have breast cancer: Mean RR (p = 0.03); SDNN (p = 0.03); RMSSD (p = 0.03); NN50 count (p = 0.03); pNN50 % (p = 0.03); RRtri (p = 0.02); SD1 (p = 0.01); SD2 (p = 0.02); LF ms2 (p = 0.01); HF ms2 (p = 0.03).There was an inversely proportional correlation between the indices SDNN, SD2, and HFms2 with triglycerides (SDNN p = 0.04; SD2 p = 0.04; HF ms2 p = 0.04). No statistically significant correlations were found between heart rate variability indices and others variables. Statistical significance was set at 5% for all analyses. Conclusion: Women with breast cancer present reduced autonomic modulation and in these women of heart rate variability indices are inversely correlated with triglyceride values.


Resumo Fundamentos: A modulação autonômica como um preditor de risco cardiovascular em mulheres com câncer de mama é importante. Objetivos: Avaliar a modulação autonômica em mulheres pós-menopausa em uso de inibidores de aromatase como tratamento de câncer de mama, e sua relação com algumas variáveis bioquímicas. Métodos: Foram avaliadas mulheres pós-menopausa sem câncer de mama (n = 33) e mulheres pós-menopausa com câncer de mama (n = 15). Para avaliação da modulação autonômica, a frequência cardíaca (FC) foi registrada batimento a batimento por 30 minutos, e as séries de intervalos RR obtidas foram usadas para o cálculo dos seguintes índices de variabilidade da frequência cardíaca: média de RR ms, SDNN (desvio padrão de todos os intervalos RR normais) ms, FC, RMSSD (raiz quadrada da média das diferenças ao quadrado entre os intervalos RR normais adjacentes) ms, contagem NN50 (número de pares de NNs sucessivos que se diferem em mais de 50 ms), pNN50% (proporção de NN50 dividida pelo número total de NNs), RRtri (RR triangular), TINN (interpolação triangular do intervalo NN) ms, DP1 ms, DP2 ms, LF (baixa frequência) ms2, HF (alta frequência) ms2, LH/HF ms2. Os valores das variáveis bioquímicas (glicemia de jejum, triglicerídeos, HDL-colesterol, e proteína C reativa) foram analisadas das amostras de sangue. O nível de significância adotado nas análises estatísticas foi de 5%. Resultados: As mulheres pós-menopausa com câncer de mama apresentaram menores índices de variabilidade da frequência cardíaca em comparação àquelas sem câncer de mama: média de RR (p = 0,03); SDNN (p = 0,03); RMSSD (p = 0,03); contagem NN50 (p = 0,03); pNN50% (p = 0,03); RRtri (p = 0,02), DP1 (p = 0,01), DP2 (p = 0,02); LF ms2 (p = 0,01); HF ms2 (p = -0,03). Observou-se uma correlação inversamente proporcional dos índices SDNN, DP2 e HF ms2 com triglicerídeos (SDNN p = 0,04, DP2 p = 0,04; HF ms2 0,04). Não houve correlação significativa entre os índices de variabilidade da frequência cardíaca e as demais variáveis. Conclusão: Mulheres com câncer de mama apresentam modulação autonômica diminuída e índices de variabilidade da FC inversamente correlacionados com valores de triglicerídeos.


Subject(s)
Humans , Male , Female , Middle Aged , Autonomic Nervous System/physiopathology , Breast Neoplasms/physiopathology , Postmenopause/physiology , Aromatase Inhibitors/therapeutic use , Heart Rate/physiology , Socioeconomic Factors , Triglycerides , Breast Neoplasms/drug therapy , Breast Neoplasms/blood , C-Reactive Protein/analysis , Cross-Sectional Studies , Predictive Value of Tests , Risk Factors , Glycemic Index , Cholesterol, HDL
15.
Rev. bras. ginecol. obstet ; 41(1): 4-10, Jan. 2019. tab
Article in English | LILACS | ID: biblio-1003517

ABSTRACT

Abstract Objective To assess the association between dietary glycemic index (GI) and excess weight in pregnant women in the first trimester of pregnancy. Methods A cross-sectional study in a sample of 217 pregnant women was conducted at the maternal-fetal outpatient clinic of the Hospital Geral de Fortaleza, Fortaleza, state of Ceará, Brazil, for routine ultrasound examinations in the period between 11 and 13 weeks + 6 days of gestation.Weight and height were measured and the gestational body mass index (BMI) was calculated. The women were questioned about their usual body weight prior to the gestation, considering the prepregnancy weight. The dietary GI and the glycemic load (GL) of their diets were calculated and split into tertiles. Analysis of variance (ANOVA) or Kruskal-Walls and chi-squared (χ2) statistical tests were employed. A crude logistic regression model and a model adjusted for confounding variables known to influence biological outcomes were constructed. A p-value < 0.05 was considered significant for all tests employed. Results The sample group presented a high percentage of prepregnancy and gestational overweight (39.7% and 40.1%, respectively). InthetertilewiththehigherGIvalue, therewasa lower dietary intake of total fibers (p = 0.005) and of soluble fibers (p = 0.008). In the third tertile, the dietary GI was associated with overweight in pregnant women in the first trimester of gestation, both in the crude model and in the model adjusted for age, total energy intake, and saturated fatty acids. However, this association was not observed in relation to the GL. Conclusion A high dietary GI was associated with excess weight in women in the first trimester of pregnancy.


Resumo Objetivo Avaliar a associação entre índice glicêmico (IG) dietético e presença de excesso de peso em gestantes no primeiro trimestre de gestação. Métodos Estudo transversal realizado com 217 gestantes atendidas no Ambulatório de Medicina Materno-Fetal do Hospital Geral de Fortaleza, Fortaleza, CE, para realização de exames ultrassonográficos de rotina no período entre 11 e 13 semanas e 6 dias de gestação. Peso e altura foram obtidos para o cálculo do índice de massa corporal (IMC) gestacional. As mulheres foram questionadas quanto ao peso corporal habitual anterior à gestação, considerado o peso pré-gestacional. O IG e a carga glicêmica (CG) das suas dietas foram calculados e divididos em tercis. As associações foram investigadas por análise de variância (ANOVA, na sigla em inglês) ou pelos testes Kruskal-Walls e qui-quadrado (χ2). Resultados O grupo tinha alto percentual de excesso de peso pré-gestacional (39,7%) e gestacional (40,1%). Houve menor consumo de fibras totais (p = 0,005) e fibras insolúveis (p = 0,008) no tercil de maior valor de IG. No terceiro tercil, o IG da dieta foi associado ao excesso de peso dasmulheres no primeiro trimestre de gestação, tanto no modelo bruto como no modelo ajustado para idade, consumo total de energia e de ácidos graxos saturados. No entanto, não se observou esta associação emrelação à CG. Conclusão O alto IG da dieta consumida foi associado ao excesso de peso das mulheres no primeiro trimestre da gestação.


Subject(s)
Humans , Female , Pregnancy , Adult , Young Adult , Pregnancy Complications/blood , Pregnancy Trimester, First/blood , Glycemic Index , Diet , Overweight/blood , Glycemic Load , Pregnancy Complications/epidemiology , Cross-Sectional Studies , Overweight/epidemiology
16.
Belo Horizonte; s.n; 2019. 87 p. ilus, tab.
Thesis in Portuguese | LILACS, BDENF | ID: biblio-1024859

ABSTRACT

Introdução: As atitudes psicológicas das pessoas acometidas por diabetes tipo 2, como tristeza e raiva ou confiança e satisfação em conviver com a condição crônica podem estar relacionadas às características sociodemográficas e ao controle glicêmico. Objetivo: Associar as atitudes psicológicas de pessoas com diabetes tipo 2 com as características sociodemográficas e o controle glicêmico. Método: O estudo utilizou o banco de dados da pesquisa intitulada: "Avaliação da efetividade de um programa educativo em diabetes mellitus tipo 2 na Atenção Primária à Saúde", que avaliou as atitudes psicológicas das pessoas com diabetes tipo 2. Trata-se de ensaio randomizado com cluster, realizado com 278 pessoas com diabetes tipo 2, em 10 Unidades Básicas de Saúde, do município de Divinópolis, Minas Gerais, entre os anos de 2013 e 2016. Cada unidade constituiu um cluster, sendo 5 delas aleatorizadas no grupo intervenção (GI=160) e as restantes, no grupo controle (GC=118). Todos os participantes continuaram recebendo o atendimento convencional oferecido nas unidades e apenas o GI participou do programa educativo, durante 12 meses. Os dados foram coletados por meio de questionário sociodemográfico no tempo inicial e do instrumento de atitudes psicológicas (ATT-19) e exame de hemoglobina glicada (Hb1Ac), nos tempos inicial e final do programa educativo. O programa Statistical Package for the Social Sciences® (SPSS), versão 20.0 foi utilizado para a realização dos testes estatísticos. As médias do escore de atitudes psicológicas e HbA1c entre GC e GI foram comparadas após término do programa educativo, utilizando o Generalized Estimating Equations Model (GEE). Os coeficientes não padronizados (ß) e seus respectivos intervalos de confiança (IC = 95%) foram calculados e apresentados. Para verificar as associações, foi calculado o valor p dos efeitos intragrupos, da interação entre tempo e grupo e da interação entre tempo, grupo e características sociodemográficas/tempo de diabetes. Foi realizada estatística descritiva com tabelas de distribuição de frequência, cálculos de medidas de tendência central e de dispersão. Considerou-se o nível de significância de 5% (p<0,05) para as análises. Resultados: Os participantes do GI terminaram a intervenção com valores maiores de atitudes psicológicas (ß=11,21; IC=95%: 7,4-15,0), quando comparados ao GC. Observou-se valor de p significativo para a interação entre tempo, grupo e escolaridade (p=0,025), o que indica que ter maior escolaridade potencializou o efeito da intervenção, uma vez que a diferença das médias de GC e GI no tempo final foram maiores entre aqueles de maior escolaridade, comparado àqueles de menor escolaridade. Considerando somente os participantes que tiveram evolução positiva dos escores de atitudes psicológicas, verifica-se que houve redução da HbA1c no GI (7,9±0,2 vs. 7,4±0,2, p<0,001) e aumento da HbA1c no GC (7,5±0,2 vs, 7,8±0,2, p=0,044) e participantes do GI apresentaram menores valores de HbA1c no tempo final em relação ao GC (ß=-0,9; IC 85%: -1,4; -0,5). Conclusão: Observou-se que a evolução positiva das atitudes psicológicas entre os participantes do programa educativo esteve associada aos maiores níveis de escolaridade e ao melhor controle glicêmico.(AU)


Subject(s)
Humans , Male , Female , Middle Aged , Attitude to Health , Diabetes Mellitus, Type 2/psychology , Emotional Adjustment , Socioeconomic Factors , Surveys and Questionnaires , Academic Dissertation , Demographic Indicators , Glycemic Index
17.
São Paulo; s.n; s.n; 2019. 129 p. graf, tab.
Thesis in Portuguese | LILACS | ID: biblio-1015416

ABSTRACT

O diabetes mellitus tipo 2 está intimamente ligado a formação de espécies reativas de oxigênio, as quais aumentam os produtos de glicação avançada e consequentemente a inflamação e o desenvolvimento das complicações associadas a doença. Nesse contexto, destaca-se o papel do microbioma intestinal, visto que esta pode ser capaz de modificar fatores ligados ao sistema imune e sua modulação pode ser uma boa alternativa para melhora do quadro inflamatório e complicações da doença. A castanha-do-brasil, fonte de selênio, além de outros nutrientes, poderia atuar no sistema de defesa antioxidante e anti-inflamatório, além de influenciar a microbiota intestinal, resultando benefícios aos pacientes. Portanto, este estudo teve como objetivo avaliar estes efeitos da suplementação de indivíduos com diabetes mellitus tipo 2, com uma nóz de castanha-do-brasil (Bertholletia excelsa H.B.K.) por dia, durante 60 dias. Para tanto, foi delineado um ensaio clínico, longitudinal, com 29 pacientes voluntários com diabetes mellitus tipo 2, atendidos no Ambulatório de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Os participantes foram avaliados antes e após a intervenção, e realizaram uma coleta de fezes (caracterização da microbiota intestinal e concentração de selênio) e uma coleta de sangue (análises de status de selênio, marcadores inflamatórios, glicêmicos e lipídicos, e da permeabilidade intestinal), a avaliação da ingestão alimentar foi por meio de Registro Alimentar de 3 dias Inicialmente, determinou-se a composição centesimal e a concentração de selênio da castanha-do-brasil utilizada. A análise bioinformática foi conduzida usando o Quantitative Insight into Microbial Ecology (QIIME, versão 1.9.0). A análise estatística foi realizada com os softwares Statistical Package for the Social Sciences, versão 23.0, e R versão 1.1.463. A concentração de selênio na castanha in natura foi de 79,8µg/g. A idade média dos participantes foi 54,9±3,6 anos. A ingestão de castanha-do-brasil foi capaz de melhorar significativamente os parâmetros: concentrações de selênio no plasma (Δ 95,82, p<0,001), nos eritrócitos (Δ 163,16, p<0,001) e nas fezes (Δ 166,31 p<0,001), assim como na selenoproteína P (Δ 5,36 p<0,026) e atividade da enzima glutationa peroxidase (Δ 30,61 p<0,040) e redução da hemoglobina glicada (Δ -0,8, p=0,001). No entanto, não houve alteração do perfil lipídico, inflamatório, ingestão alimentar e marcadores antropométricos. Apesar de não verificarmos mudança na composição global da microbiota intestinal, a diversidade interpessoal (ß diversidade) variou conforme a concentração de selenoproteína P (p=0,03) e porcentagem de hemoglobina glicada (p=0,04). A suplementação com castanha-do-brasil melhorou o perfil glicêmico e o status de selênio. Apesar de não ser observada influência na composição global da microbiota, a segregação observada indica certa resistência da microbiota frente a intervenção com a castanha


Type 2 diabetes mellitus is closely linked to the formation of reactive oxygen species, such as those that increase advanced glycation products (AGEs) and, consequently, inflammation and the development of complications associated with this disease. In this context, the study of the intestinal microbiome is of extreme importance, since it may be able to alter the factors related to the immune system and its modulation may be a good alternative for the improvement of the clinical and inflammatory status. Brazil nut is rich in selenium, in addition to other nutrients, which could act in the anti-inflammatory and antioxidant defense system and influence intestinal microbiota composition. Therefore, this study had the objective of determining the supplementation with type 2 diabetes mellitus. This longitudinal clinical trial was designed with 29 patients with type 2 diabetes mellitus, attended at the Endocrinology Outpatient Clinic of the Hospital das Clínicas, Faculdade de Medicina of the University of São Paulo. The intervention with Brazil nuts lasted 60 days and the participants were evaluated before and after by a collection of feces (intestinal microbiota characterization and selenium concentration) and blood collection (analyzes of selenium status, inflammatory markers, glycemic and lipid levels, and intestinal permeability), and dietary intake by means of a 3-day Food Registry. Initially, the centesimal composition and the selenium concentration of the nut were determined used. Bioinformatic analysis was conducted using the Quantitative Insight into Microbial Ecology (QIIME, version 1.9.0). Statistical analysis was performed with the software Statistical Package for the Social Sciences, version 23.0, and R version 1.1.463. The concentration of selenium in the nut in natura was 79.8 µg / g. The mean age of the participants was 54.9 ± 3.6 years, the mean time of diagnosis of the disease was 11.7 ± 6.9 years. The Brazil nut intake was able to significantly improve the parameters: plasma selenium concentrations (Δ 95,82, p<0,001), nem da circunferência da cintura (Δ-1 p=0,217) and GPX (Δ30.61 p <0.040) and reduction in HbA1c (Δ -0.8, p = 0.001). However, there were no changes in the lipid profile, inflammation, food intake and anthropometric markers. Although we did not verify a change in the global composition of the intestinal microbiota, the interpersonal diversity (ß diversity) varied according to the concentration of SELENOP (p = 0.03) and HbA1c percentage (p = 0.04). We conclude that brazil nut supplementation improved the glycemic profile and the status of selenium. Although no influence was observed on the overall composition of the microbiota, the observed segregation indicates some resistance of the microbiota to the intervention with the chestnut


Subject(s)
Humans , Male , Female , Middle Aged , Dietary Supplements/adverse effects , Bertholletia/adverse effects , Diabetes Mellitus, Type 2/drug therapy , Selenium/agonists , Glycemic Index , Gastrointestinal Microbiome , Inflammation/classification
18.
Epidemiol. serv. saúde ; 28(2): e2018298, 2019. tab
Article in English, Portuguese | LILACS | ID: biblio-1012083

ABSTRACT

Objetivo: descrever a prevalência de doenças crônicas não transmissíveis (DCNT), uso de medicamentos, valores tensionais e glicemia capilar de uma equipe de enfermagem de um hospital filantrópico de Pelotas, RS, Brasil. Métodos: estudo transversal; as perguntas foram adaptadas do questionário do sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (Vigitel); todos tiveram pressão arterial e glicemia aferidos. Resultados: do total de 272 funcionários avaliados, 29,4% afirmaram ter DCNT, 48,9% faziam uso de medicamento contínuo e 73,9% referiram antecedentes familiares para DCNT; dos entrevistados, 20,6% usavam anti-hipertensivos, e destes, 27,7% apresentaram níveis tensionais elevados e 2,6% referiram usar hipoglicemiantes; destes últimos, 42,9% apresentaram níveis glicêmicos elevados. Conclusão: dos profissionais autodeclarados hipertensos e diabéticos, aqueles em uso de medicações apresentaram valores tensionais e glicemia mais elevados do que os que não faziam tratamento medicamentoso.


Objetivo: Describir la prevalencia de enfermedades crónicas no transmisibles (ECNT), uso de medicamentos y valores de tensión y glucemia capilar de un equipo de enfermería de un hospital filantrópico de Pelotas/RS. Métodos: Estudio transversal; las preguntas fueron adaptadas del cuestionario Vigilancia de Factores de Riesgo y Protección para Enfermedades Crónicas por Encuesta Telefónica (Vigitel). Todos tuvieron la presión arterial y la glucemia medidas. Resultados: Del total de 272 funcionarios evaluados, un 29,4% reportó tener ECNT, un 48,9% hacía uso de medicamento continuado y 73,9% refería antecedentes familiares para ECNT. Entre los entrevistados, 20,6% refirió usar antihipertensivos, de estos 27,7% presentaron niveles de tensión elevados, y un 2,6% refirieron usar hipoglucemiantes, de los cuales 42,9% presentó niveles glucémicos elevados. Conclusión: Los profesionales que se autodeclararon hipertensos y diabéticos y estaban en uso de medicamentos presentaron valores de tensión y glucemia más elevados que aquellos que no hacían tratamiento medicamentoso.


Objective: to describe the prevalence of noncommunicable diseases (NCDs), long term (current) drug therapy, blood pressure levels and capillary glycemia among a nursing team at a charitable hospital in Pelotas/RS. Methods: This was a cross-sectional study. The questions were adapted from the Vigitel system questionnaire (Telephone Surveillance of Chronic Disease Risk and Protection Factors). All participants had their blood pressure and blood glucose measured. Results: Of the 272 staff assessed, 29.4% reported having NCDs, 48.9% were on long term (current) drug therapy and 73.9% reported a family history of NCDs. Among those interviewed, 20.6% reported using antihypertensive drugs, of these 27.7% had high blood pressure levels, and 2.6% reported using antihypoglycemic agents, 42.9% of whom had high blood glucose. Conclusion: Among those professionals who stated they had high blood pressure and diabetes, those who were on medication had higher blood pressure and glucose levels than those who were not on medication.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Chronic Disease/epidemiology , Occupational Health/trends , Diabetes Mellitus/epidemiology , Surveillance of the Workers Health , Hypertension/epidemiology , Nursing, Team/statistics & numerical data , Brazil , Socioeconomic Analysis , Cross-Sectional Studies , Blood Pressure Monitoring, Ambulatory , Glycemic Index , Diagnostic Self Evaluation , Hypoglycemic Agents/therapeutic use , Antihypertensive Agents/therapeutic use
19.
Article in English | WPRIM | ID: wpr-785793

ABSTRACT

Over the last decade, genome-wide association studies (GWASs) have provided an unprecedented amount of genetic variations that are associated with various phenotypes. However, previous GWAS were mostly conducted in European populations, and these biased results for non-Europeans may result in a significant reduction in risk prediction for non-Europeans. An issue with the early GWAS was the winner's curse problem, which led to misleading results when constructing the polygenic risk scores (PRS). Therefore, more non-European population-based studies are needed to validate reported variants and improve genetic risk assessment across diverse populations. In this study, we validated 422 variants independently associated with glycemic indexes, liver enzymes, and type 2 diabetes in 125,872 samples from a Korean population, and further validated the results by assessing publicly available summary statistics from European GWAS (n = 898,130). Among the 422 independently associated variants, 284, 320, and 361 variants were replicated in Koreans, Europeans, and either one of the two populations. In addition, the effect sizes for Koreans and Europeans were moderately correlated (r = 0.33–0.68). However, 61 variants were not replicated in both Koreans and Europeans. Our findings provide valuable information on effect sizes and statistical significance, which is essential to improve the assessment of disease risk using PRS analysis.


Subject(s)
Asian Continental Ancestry Group , Bias , Genetic Variation , Genome-Wide Association Study , Glycemic Index , Humans , Liver , Phenotype , Polymorphism, Single Nucleotide , Risk Assessment
20.
Article in English | WPRIM | ID: wpr-741707

ABSTRACT

BACKGROUND/OBJECTIVES: The glycemic index (GI) is a measure of the postprandial glucose response (PPGR) to food items, and glycemic load (GL) is a measure of the PPGR to the diet. For those who need to maintain a healthy diet, it is beneficial to regulate appropriate levels of blood glucose. In reality, what influences the meal GI or GL depends on the macronutrient composition and the physical chemistry reactions in vivo. Thus, we investigated whether different macronutrients in a meal significantly affect the PPGR and the validity of calculated GI and GL values for mixed meals. SUBJECTS/METHODS: 12 healthy subjects (6 male, 6 female) were recruited at a campus setting, and subjects consumed a total of 6 test meals one by one, each morning between 8:00 and 8:30 am after 12 h of fasting. PPGR was measured after each consumed meal and serial finger pricks were performed at indicated times. Test meals included 1) 68 g oral glucose, 2) 210 g rice, 3) rice plus 170 g egg white (RE), 4) rice plus 200 g bean sprouts (RS), 5) rice plus 10 g oil (RO), and 6) rice plus, egg white, bean sprouts, and oil (RESO). The incremental area under the curve (iAUC) was calculated to assess the PPGR. Mixed meal GI and GL values were calculated based on the nutrients the subjects consumed in each of the test meals. RESULTS: The iAUC for all meals containing two macronutrients (RS, RO, or RE) were not significantly different from the rice iAUC, whereas, the RESO iAUC (2,237.5 ± 264.9) was significantly lower (P < 0.05). The RESO meal's calculated GI and GL values were different from the actual GI and GL values measured from the study subjects (P < 0.05). CONCLUSIONS: The mixed meal containing three macronutrients (RESO) decreased the PPGR in healthy individuals, leading to significantly lower actual GI and GL values than those derived by nutrient-based calculations. Thus, consuming various macronutrient containing meals is beneficial in regulating PPGR.


Subject(s)
Blood Glucose , Chemistry, Physical , Diet , Egg White , Fasting , Fingers , Glucose , Glycemic Index , Glycemic Load , Healthy Volunteers , Humans , Male , Meals
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