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1.
Braz. j. biol ; 84: e254011, 2024. graf
Article in English | LILACS, VETINDEX | ID: biblio-1355886

ABSTRACT

Abstract Livestock is a fundamental part of the agriculture industry in Pakistan and contributes more than 11.53% to GDP. Among livestock species, the buffaloes are regarded as the black gold of Pakistan. Being the highest milk producers globally, Nili-Ravi buffaloes are the most famous ones. Buffaloes are affected by many endemic diseases, and "Hemorrhagic septicemia" (HS) is one of them. This study was designed to ascertain the effects of experimental exposure ofP. multocida B:2 (oral) and its immunogens, i.e., LPS (oral and intravenous) and OMP (oral and subcutaneous) on reproductive hormonal profiles in Nili-Ravi buffaloes. Repeated serum samples were collected from the jugular vein of experimental animals for 21 days (0, 02, 04, 08, 12, 16, 20, 24, 36, 48, 72, 120, 168, 216, 264, 360, 456 and 504 hours). Hormonal assays to determine the serum concentrations of Gonadotropin-releasing hormone (GnRH), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), Estrogen (E2) and progesterone (P4) were performed using (MyBioSource) commercial Elisa kits. The hormonal profile of all treatment groups of the buffalo heifers exhibited significant (P<0.05) variations as compared to the control group (G-1). These results indicate suppression in Nili-Ravi buffaloes' reproductive hormonal profile on exposure to P. multocida B:2 and its immunogens. This influence warrants that exposure to H.S may be a possible reason for delayed puberty and poor reproduction performance in Nili-Ravi buffaloes.


Resumo A pecuária é uma parte fundamental da indústria agrícola no Paquistão e contribui com 11,53% do PIB nacional. Entre as espécies de gado, os búfalos são considerados o ouro negro do Paquistão. Sendo os maiores produtores de leite em todo o mundo, os búfalos Nili-Ravi são os mais famosos. Os búfalos são afetados por muitas doenças endêmicas, entre as quais a "septicemia hemorrágica" (SH). Este estudo busca verificar os efeitos da exposição experimental de P. multocida B:2 (oral) e seus imunógenos, ou seja, LPS (oral e intravenoso) e OMP (oral e subcutâneo), nos perfis hormonais reprodutivos em búfalos Nili-Ravi. Amostras de soro repetidas foram coletadas da veia jugular de animais experimentais por 21 dias (0, 2, 4, 8, 12, 16, 20, 24, 36, 48, 72, 120, 168, 216, 264, 360, 456 e 504 horas). Os ensaios hormonais para determinar as concentrações séricas do hormônio liberador de gonadotrofina (GnRH), hormônio foliculoestimulante (FSH), hormônio luteinizante (LH), estrogênio (E2) e progesterona (P4) foram realizados usando kits comerciais Elisa (MyBioSource). O perfil hormonal de todos os grupos de tratamento das novilhas bubalinas apresentou variações significativas (P < 0,05) em relação ao grupo controle (G-1). Esses resultados indicam supressão no perfil hormonal reprodutivo de búfalos Nili-Ravi na exposição a P. multocida B:2 e seus imunógenos. Essa influência garante que a exposição à SH possa ser uma possível razão para o atraso da puberdade e o baixo desempenho reprodutivo em búfalos Nili-Ravi.


Subject(s)
Animals , Female , Pasteurella Infections/veterinary , Reproduction , Gonadal Steroid Hormones/blood , Buffaloes , Progesterone , Cattle , Lipopolysaccharides , Gonadotropin-Releasing Hormone , Pasteurella multocida
2.
Article in Chinese | WPRIM | ID: wpr-927392

ABSTRACT

OBJECTIVE@#To compare the improvement effect between simultaneous electroacupuncture at antagonistic muscle and agonistic muscle and simple electroacupuncture at antagonistic muscle on spasticity degree, upper-extremity motor function and activity of daily living in patients with upper-extremity spasticity after stroke.@*METHODS@#A total of 60 patients with upper-extremity spasticity after stroke were randomized into a comprehensive group (30 cases, 1 case dropped off) and an antagonistic muscle group (30 cases, 2 cases dropped off). In the antagonistic muscle group, acupuncture was applied at Jianyu (LI 15), Binao (LI 14), Zhouliao (LI 12), Shousanli (LI 10), Waiguan (TE 5) and Houxi (SI 3), electric stimulation was attached to Jianyu (LI 15)-Binao (LI 14), Zhouliao (LI 12)-Shousanli (LI 10) and Waiguan (TE 5)-Houxi (SI 3), with discontinuous wave, 15 Hz in frequency. On the basis of the treatment in the antagonistic muscle group, acupuncture was applied at Tianquan (PC 2), Chize (LU 5), Jianshi (PC 5) and Daling (PC 7) in the comprehensive group, electric stimulation was attached to Tianquan (PC 2)-Chize (LU 5) and Jianshi (PC 5)-Daling (PC 7), with continuous wave, 5 Hz in frequency. The treatment was given once a day, 6 days a week for 4 weeks in the two groups. Before and after treatment, the scores of modified Ashworth scale (MAS), Fugl-Meyer assessment upper extremity scale (FMA-UE) and modified Barthel index (MBI) scale were observed in the two groups.@*RESULTS@#Compared before treatment, the MAS scores of elbow flexors and wrist flexors after treatment were decreased (P<0.05), the scores of FMA-UE and MBI scale after treatment were increased in the two groups (P<0.05). The scores of FMA-UE and MBI scale after treatment in the comprehensive group were higher than those in the antagonistic muscle group (P<0.05).@*CONCLUSION@#Simultaneous electroacupuncture at antagonistic muscle and agonistic muscle and simple electroacupuncture at antagonistic muscle can both improve the spasticity degree in patients with upper-extremity spasticity after stroke, however, the former can better restore motor function and improve activity of daily living.


Subject(s)
Electroacupuncture , Gonadal Steroid Hormones , Humans , Muscle Spasticity/therapy , Muscles , Stroke/therapy , Stroke Rehabilitation , Treatment Outcome , Upper Extremity
3.
Saúde Soc ; 31(1): e210116, 2022.
Article in Portuguese | LILACS | ID: biblio-1352216

ABSTRACT

Resumo Este artigo analisa a percepção de homens usuários de testosterona acerca dos efeitos adversos no uso do hormônio, a fim de refletir sobre a eficácia e o alcance de ações em saúde voltadas para essa prática. Os dados empíricos foram obtidos a partir de 21 relatos de história de vida de homens que utilizam a testosterona, com ou sem acompanhamento médico, de perfil variado, coletados em 2016 majoritariamente no Rio de Janeiro. A discussão se apoia nos estudos de gênero e de masculinidades para argumentar como os homens interpretam os impactos do uso da testosterona a partir de uma valorização de características masculinas associadas a um ideal normalizador de masculinidade. Os resultados apontam uma percepção generalizada no campo de que o hormônio causa pouco ou nenhum mal, através de um processo de invisibilização ou ressignificação dos efeitos potencialmente negativos. Além disso, há um movimento de deslocamento dos problemas associados ao uso a personagens estereotipadas, num processo de desresponsabilização de si e reafirmação de atributos de um ideal de masculinidade. Com isso, busca-se contribuir para a construção de ações em saúde mais adequadas ao cotidiano dos usuários e, portanto, mais eficazes.


Abstract This article analyzes the perception of male users of testosterone about the adverse effects of the hormone, aiming to challenge the effectiveness and scope of health actions for this practice. Empirical data were obtained in 2016, mostly in Rio de Janeiro, from life history interviews with 21 male users of testosterone, with or without medical monitoring, from different backgrounds. In the light of gender and masculinity studies, it discusses how men interpret the impacts of testosterone use from a social valuation of certain traits associated with a normalizing manhood ideal. Results indicate an invisibilization or re-signification of potentially negative effects of the hormone, culminating in a widespread perception that it causes little or no harm. The problems associated with testosterone use acquire stereotyped characters, through a process of denying self-responsibility and reaffirming attributes of an ideal type of masculinity. This study is expected to contribute to the development of more adequate and thus more effective health actions to users' daily lives.


Subject(s)
Humans , Male , Gonadal Steroid Hormones , Testosterone/adverse effects , Masculinity
4.
Femina ; 49(10): 631-635, 20211031. ilus
Article in Portuguese | LILACS | ID: biblio-1358197

ABSTRACT

Objetivo: Revisar a implicação e a relação existente entre a microbiota intestinal e a síndrome do ovário policístico (SOP). Métodos: Trata-se de uma revisão sistemática de artigos das bases de dados PubMed, Cochrane e Science Direct dos últimos cinco anos, nos idiomas inglês, português e espanhol. Resultados: A disbiose da microbiota intestinal ativa o sistema imunológico do hospedeiro. Tal ativação interfere na função do receptor de insulina, causando hiperinsulinemia, o que aumenta a produção de androgênio ovariano e dificulta o desenvolvimento de um folículo saudável. Além disso, pacientes com SOP apresentam o perfil taxonômico alterado, o qual se associou inversamente com excesso de andrógenos e inflamação da SOP. Foi evidenciado que o uso de probióticos pode regular a resposta inflamatória, diminuir os níveis totais de testosterona e contribuir para que a SOP não prejudique uma possível gravidez. Conclusão: Essa revisão sugere que há íntima associação entre a disbiose microbiana e as alterações patológicas que ocorrem na SOP. Assim, a suplementação de probióticos em tais pacientes pode ter grandes benefícios, como melhora dos sintomas e redução das repercussões da doença.(AU)


Objective: To review the implication and the relationship between the intestinal microbiota and polycystic ovary syndrome. Methods: This is a systematic review of articles from the PubMed, Cochrane and Science Direct databases, from the last five years, in English, Portuguese and Spanish. Results: Dysbiosis of the intestinal microbiota activates the host's immune system. Such activation interferes with the function of the insulin receptor, causing hyperinsulinemia, which increases the production of ovarian androgens and hinders the development of a healthy follicle. In addition, patients with PCOS have an altered taxonomic profile, which is inversely associated with excess androgens and PCOS inflammation. It was evidenced that the use of probiotics can regulate the inflammatory response, decrease the total testosterone levels and contribute so that PCOS does not harm a possible pregnancy. Conclusion: This review suggests that there is a close association between microbial dysbiosis and pathological changes that occur in PCOS. Thus, supplementation of probiotics in such patients can have great benefits, such as improving symptoms and reducing the repercussions of the disease.(AU)


Subject(s)
Humans , Female , Polycystic Ovary Syndrome/microbiology , Gastrointestinal Microbiome , Gonadal Steroid Hormones , Insulin Resistance , Databases, Bibliographic , Dysbiosis
5.
Revagog ; 3(3): 78-79, Jul-Sept. 2021.
Article in Spanish | LILACS, LIGCSA | ID: biblio-1343840

ABSTRACT

La pandemia de coronavirus-2 (SARS-CoV-2) relacionada con el SARS 2019-2020 ha traído desafíos sin precedentes a los sectores de la salud en todo el mundo. Hasta noviembre de 2020, ha habido más de 64 millones de casos confirmados y se acercan a 2 millones de muertes en todo el mundo. A pesar de la gran cantidad de casos positivos, existen muy pocos estándares establecidos de atención y opciones terapéuticas disponibles. Hasta la fecha, (Diciembre 2020) todavía no existe una vacuna aprobada por la Administración de Alimentos y Medicamentos (FDA) para COVID-19, aunque existen varias ensayos clínicos en diferentes. etapas de desarrollo. En este documento, hemos realizado una revisión global que evalúa los roles de la edad y el sexo en las hospitalizaciones por COVID-19, las admisiones a la UCI, las muertes en hospitales y las muertes en hogares de ancianos. Hemos identificado una tendencia en la que las personas mayores y los pacientes masculinos se ven afectados significativamente por los resultados adversos.


Subject(s)
Humans , Female , Middle Aged , Aged , Gonadal Steroid Hormones/pharmacology , Hormone Replacement Therapy , SARS-CoV-2 , COVID-19/mortality , Estrogens , Gender Role , COVID-19/drug therapy
6.
Asian Journal of Andrology ; (6): 479-483, 2021.
Article in English | WPRIM | ID: wpr-888459

ABSTRACT

The novel coronavirus disease (COVID-19) pandemic is emerging as a global health threat and shows a higher risk for men than women. Thus far, the studies on andrological consequences of COVID-19 are limited. To ascertain the consequences of COVID-19 on sperm parameters after recovery, we recruited 41 reproductive-aged male patients who had recovered from COVID-19, and analyzed their semen parameters and serum sex hormones at a median time of 56 days after hospital discharge. For longitudinal analysis, a second sampling was obtained from 22 of the 41 patients after a median time interval of 29 days from first sampling. Compared with controls who had not suffered from COVID-19, the total sperm count, sperm concentration, and percentages of motile and progressively motile spermatozoa in the patients were significantly lower at first sampling, while sperm vitality and morphology were not affected. The total sperm count, sperm concentration, and number of motile spermatozoa per ejaculate were significantly increased and the percentage of morphologically abnormal sperm was reduced at the second sampling compared with those at first in the 22 patients examined. Though there were higher prolactin and lower progesterone levels in patients at first sampling than those in controls, no significant alterations were detected for any sex hormones examined over time following COVID-19 recovery in the 22 patients. Although it should be interpreted carefully, these findings indicate an adverse but potentially reversible consequence of COVID-19 on sperm quality.


Subject(s)
Adult , Asthenozoospermia/virology , COVID-19/physiopathology , China , Gonadal Steroid Hormones/blood , Humans , Male , Progesterone/blood , Prolactin/blood , SARS-CoV-2 , Semen/physiology , Semen Analysis , Sperm Count , Sperm Motility , Spermatozoa/physiology , Time Factors
7.
Braz. J. Pharm. Sci. (Online) ; 57: e19139, 2021. graf
Article in English | LILACS | ID: biblio-1350244

ABSTRACT

Dehydroepiandrosterone (DHEA) is a steroid hormone secreted by the adrenal glands, gonads and brain. It is a precursor to sex hormones and also is known to have immune modulatory activity. However, little is known about the relationship between DHEA and neutrophils and thus our study evaluates the influence of DHEA in the effector functions of neutrophils. Human neutrophils were treated in vitro with DHEA and further infected with Salmonella enterica serovar Typhimurium. The treatment of neutrophils with 0.01 µM of DHEA increased the phagocytosis of Salmonella independent of TLR4 as the treatment did not modulate the TLR4 expression. Additionally, DHEA caused a decrease in ROS (reactive oxygen species) production and did not influence the formation of the neutrophil extracellular trap (NET). Steroid treated neutrophils, infected or stimulated with LPS (lipopolysaccharide), showed reduced production of IL-8, compared to untreated cells. Also, the protein levels of p-NFκB were decreased in neutrophils treated with DHEA, and this reduction could explain the reduced levels of IL-8. These results led us to conclude that the steroid hormone DHEA has important modulatory functions in neutrophils


Subject(s)
Humans , Male , Adult , In Vitro Techniques , Dehydroepiandrosterone/analysis , Neutrophils/metabolism , Phagocytosis/genetics , Gonadal Steroid Hormones/pharmacology , Adrenal Glands/metabolism , Salmonella enterica/classification
9.
Actual. osteol ; 16(3): 176-186, 2020. ilus
Article in Spanish | LILACS | ID: biblio-1253780

ABSTRACT

Una persona transgénero es aquella en la cual el género autopercibido difiere del asignado al nacer, mientras que el término cisgénero es utilizado en aquellos individuos no trans. El tratamiento hormonal cruzado (THC) constituye una opción para lograr caracteres sexuales secundarios deseados. Es conocido que los esteroides sexuales desempeñan un rol fundamental en la adquisición de la densidad mineral ósea (DMO) durante la pubertad. Por lo tanto, el impacto del THC sobre la masa ósea se ha convertido en materia de estudio. En estadios puberales tempranos, los análogos de la hormona liberadora de gonadotrofinas (GnRH) son utilizados con un efecto reversible. Si bien la DMO parece mantenerse estable, cuando se compara con una población de referencia del mismo sexo biológico y edad, el Z-score se encuentra por debajo de lo esperado. En adultos, durante el THC no se informaron disminuciones en la DMO. Está reportado que las mujeres trans antes del inicio del TH presentan características densitométricas diferentes de los hombres cisgénero. Hasta el momento, la carga de datos para los calculadores del riesgo de fractura y el software del equipo DXA se basan en el sexo biológico y no en identidad de género. Recientemente, la International Society for Clinical Densitometry (ISCD) emitió sus recomendaciones para la evaluación de la masa ósea en personas transgénero y en aquellos individuos no conformes con el género. Si bien la ISCD sugiere realizar la evaluación únicamente en aquellos pacientes con factores de riesgo, es de importancia realizar DXA basal, sobre todo en mujeres transgénero, para determinar el riesgo inicial de dicha población. En este artículo se revisa la evidencia disponible sobre el impacto del THC en la salud ósea de personas transgénero. (AU)


Cross sex hormone therapy (CSHT) in transgender women (TW) it is an option to achieve desired secondary sexual characteristics. It is known that sex steroids play a fundamental role in the acquisition of bone mineral density during puberty, in addition to determining a different characteristic bone pattern between both biological sexes. So the impact of affirming HT on bone is it has become in subject of study. In early pubertal stages, GnRH analogs are used with a reversible effect. Although bone mineral density (BMD) seems to remain stable, when compared with a reference population of the same biological sex and age, the Z-score is lower than expected. In adults, during CSHT no decreases in BMD were reported. However, it was reported that TW prior to starting CSHT present different densitometric characteristics than cisgender men. So far, the data load for the fracture risk calculators and DXA software is based on biological sex and not gender identity. Recently the ISCD issued its recommendations for the evaluation of bone mass in transgender subjects and in those non-conforming to gender. Although the ISCD suggests performing the evaluation only in those patients with risk factors, our group recognizes that baseline DXA, especially in TW, constitutes a useful tool to determine the initial risk of this population. Our proposal arises from our own experience and from that compiled in the international literature, where it is observed that even without starting CSHT, transgender women have lower BMD. DXA. This article reviews the available evidence regarding the effect of CSHT on health bone in transgender people. (AU)


Subject(s)
Humans , Male , Female , Bone Density/drug effects , Cisgender Persons , Gonadal Steroid Hormones/therapeutic use , Testosterone/therapeutic use , Sex Factors , Risk Factors , Gonadotropin-Releasing Hormone/analogs & derivatives , Puberty , Sex Characteristics , Densitometry , Estrogens/therapeutic use , Sex Reassignment Procedures , Transgender Persons , Androgen Antagonists/therapeutic use
10.
Rev. Ciênc. Plur ; 6(1): 71-86, 2020. tab
Article in Portuguese | LILACS, BBO | ID: biblio-1052629

ABSTRACT

Introdução:Durante a gravidez, os hormônios sexuais, estrógeno e progesterona, aumentam significativamente no organismo da mulher e parecem exercer efeitos marcantes e potencialmente prejudiciais sobre o metabolismo tecidual sendo, portanto, um fator agravante para oaumento da incidência da doença periodontal nesse período, assim como para o aumento da severidade da doença quando já instalada. Além disso, durante o período de gestação, ocorrem alterações nos níveis hormonais modificando as chances da doença periodontal se instalar ou se agravar. Objetivo:Estudar a prevalência e a severidade da doença periodontal, a identificação de dieta, higiene bucal e levantamento de lesões brancas ativas de esmaltenas gestantes cadastradas no Programa Pré-natal em umaUnidade Básica de Saúde em Natal/RN. Método:O estudo se caracteriza como seccional, descritivo e observacional, tendo como público alvo as gestantes cadastradas no programa de Pré-natal da Unidade de Saúde de Aparecida. Foram incluídas 30 gestantes em estágios diversos de gravidez. Para a análise das condições periodontais utilizou-se Índice Periodontal Comunitário. Os dados obtidos foram tabulados em planilha Excel, a partir dos quais foram calculadas médias e os respectivos desvios-padrão. Além disso foi aplicado um questionário com questões semiestruturadas para a identificação de dieta, higiene bucal e levantamento de lesões brancas ativas de esmalte. Resultados:Constatou-se que metade das gestantes adotavam dieta rica em carboidratos, e de um modo geral, apresentavam higiene bucal insatisfatória; presença de lesão branca de esmalte ativa na maioria das gestantes examinadas; a condição periodontal avaliada por meio do índice escolhido queevidenciou alta prevalência de cálculo dentário, sangramento gengival ebolsas periodontais entre os sextantes examinados. Conclusões:De forma geral, as gestantes apresentaram uma condição de saúde bucal precária, com altas médias dos componentes do índice usadoe presença de lesões brancas ativas de esmalte.(AU).


Introduction:During pregnancy, the sex hormones, estrogen and progesterone, increase significantly in the woman's body and seem to exert significant and potentially harmful effects on the tissue metabolism and, therefore, an aggravating factor to increase the incidence of periodontal disease in this period, as well as to increase the severity of the disease when already installed. In addition, during the gestation period, changes in hormone levelsoccur, modifying the chances of periodontal disease if it installs or worsens.Objective:To study the prevalence and severity of periodontal disease, identification of diet, oral hygiene and survey of active White enamel lesions among pregnant women enrolled in the Pré-natal Program in aBasic Health Unitin Natal/RN. Methods:The study is characterized as sectional, descriptive and observational, with the target group of pregnant women enrolled in the Pré-natal Program of the Aparecida Health Unit. Thirty pregnant women were included in various stages of pregnancy. Periodontal Community Index was used to analyze the periodontal conditions. The data obtained were tabulated in Excel spreadsheet, from this mean and the respective standard deviations were calculated. 10390In addition, a questionnaire with semistructured questions was applied to the identification of diet, oral hygiene and survey of active white lesions of enamel. Results:It was found that half of the pregnant women adopted a diet rich in carbohydrates, and, in general, presented poor oral hygiene; presence of active enamel white lesion in the majority of pregnant women examined; the periodontal condition evaluated through of theshowed a high prevalence of dental calculus, gingival bleeding and periodontal pockets among the sextants examined.Conclusions:In general, the pregnant women presented a precarious oral health condition, with high mean values of the components of the used indexand the presence of active enamel white lesions.(AU).


Introducción:durante el embarazo, las hormonas sexuales, el estrógeno y la progesterona, aumentan significativamente en el cuerpo de la mujer y parecen tener efectos marcados y potencialmente dañinos en el metabolismo de los tejidos, por lo que son un factor agravante de la mayor incidencia de enfermedad periodontal en este período. Así como para aumentar la gravedad de la enfermedad cuando ya está instalada. Además, durante el período de gestación, se producen cambios en los niveles hormonales, lo que cambia las posibilidades de que la enfermedad periodontal se estabilice o empeore. Objetivo:Estudiar la prevalencia y la gravedad de la enfermedad periodontal, identificación de la dieta, higiene bucal y estudio de lesiones activas del esmalte blanco en mujeres embarazadas registradas en el Programa Pré-natal en unaUnidad de SaludBásica en Natal/RN. Método:El estudio se caracteriza por ser descriptivo, descriptivo y observacional, dirigido a mujeres embarazadas registradas en el programa Pré-natal de la Unidad de Salud de Aparecida. Se incluyeron treinta mujeres embarazadas en diferentes etapas del embarazo. Para el análisis de las condiciones periodontales, se utilizó un índice periodontal comunitario. Los datos obtenidos se tabularon en una hoja de cálculo Excel, a partir de la cual se calcularon los promedios y las respectivas desviaciones estándar. Además, se aplicó un cuestionario con preguntas semiestructuradas para identificar la dieta, la higiene bucal y la encuesta de las lesiones activas del esmalte blanco. Resultados: encontró que la mitad de las mujeres embarazadas adoptaron una dieta rica en carbohidratos y, en general, presentaron una higiene bucal insatisfactoria; presencia de lesión del esmalte blanco activa en la mayoría de las embarazadas examinadas; La condición periodontal evaluada mediante el índicemostró una alta prevalencia de cálculo dental, sangrado gingival y bolsas periodontales entre los sextantes examinados. Conclusiones:en general, las mujeres embarazadas presentaron una condición de salud bucal precaria, con promedios altos de los componentes del índice utilizadoy la presencia de lesiones activas de esmalte blanco.(AU).


Subject(s)
Humans , Female , Pregnancy , Adult , Periodontal Diseases , Brazil , Health Centers , Oral Health , Pregnant Women , Oral Hygiene , Gonadal Steroid Hormones , Periodontal Index , Epidemiology, Descriptive , Observational Studies as Topic
11.
Article in Chinese | WPRIM | ID: wpr-828169

ABSTRACT

Wireless power transfer (WPT) is a new power transmission way, which can be widely used in electric vehicles and other fields. Its electromagnetic environment must be analyzed to ensure safe application. A low-power wireless power transfer system experimental platform was built, with 25 W receiving power and 47 kHz resonant frequency, which was used to carry out animal experiments. Treatment mice were exposed to environment of wireless power transfer system for 5 h a day and 6 days as one cycle. At the end of every cycle, learning memory behavior of mice were detected in T-shaped maze. The exposure experiment lasted for 12 weeks. Finally, immune parameters, sex hormones and part of organ physiological structure were detected. The results are as follows: as exposure time increased, memory behavior of mice did not change obviously with no statistical difference in sex hormone either ( > 0.05), the concentration of immune factors including tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and interleukin-1 beta (IL-1β) significantly increased ( < 0.05), and the structure of some organs showed some changes. The experimental results show that the environment of the wireless power transfer system has no effect on the memory behavior of mice, and has some effect on physiological properties of mice.


Subject(s)
Animals , Cytokines , Electric Power Supplies , Electricity , Electromagnetic Fields , Gonadal Steroid Hormones , Memory , Mice , Wireless Technology
12.
Article in Chinese | WPRIM | ID: wpr-826725

ABSTRACT

OBJECTIVE@#To evaluate the effectiveness and possible mechanism of acupuncture treatment for negative emotion in patients with polycystic ovary syndrome (PCOS).@*METHODS@#A total of 40 PCOS patients were randomly divided into an observation group and a control group, 20 cases in each one. Both groups received lifestyle interventions (exercise and diet guidance) on the 5th day of menstruation. On the basis of above treatment, the patients in the observation group received acupuncture at Guanyuan (CV 4), Zhongwan (CV 12), Guilai (ST 29), Futu (ST 32), Liangqiu (ST 34), Sanyinjiao (SP 6), Zusanli (ST 36), Hegu (LI 4), Shenmen (HT 7), Baihui (GV 20) as the main acupoints, and connected the electroacupuncture (continuous wave, 2 Hz, 30 min), once every other day, 3 times a week. The treatment for 1 month was as one course and 4 courses were required totally in both groups. Before and after treatment, the body mass index (BMI), ferriman-gallway (F-G) score, self-rating anxiety scale (SAS) score, self-rating depression scale (SDS) score, PCOS health-related quality of life questionnaire (PCOSQ) score were observed, meanwhile, serum sex hormone, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E), progestin (P), prolactin (PRL), testosterone (T), sex hormone-binding globulin (SHBG) and free androgen index (FAI) levels, and serumβ-endorphin levels were detected.@*RESULTS@#Compared with before treatment, the BMI, F-G score, SAS score, SDS score and serum FAI level were decreased and the PCOSQ score and the levels of serum SHBG andβ-endorphin were increased in the observation group after treatment (all <0.05). Compared with before treatment, the SDS score was decreased in the control group after treatment (<0.05). Compared with the control group, the F-G score, SDS score, SAS score, and serum FAI level were lower, and the PCOSQ score and serumβ-endorphin level were higher in the observation group after treatment (all <0.05).@*CONCLUSION@#Applying acupuncture to the treatment of patients with PCOS can effectively relieve anxiety and depression, and the mechanism may be related to the regulation on the levels of serumβ-endorphin and androgen.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Anxiety , Therapeutics , Depression , Therapeutics , Emotions , Female , Gonadal Steroid Hormones , Blood , Humans , Polycystic Ovary Syndrome , Psychology , Therapeutics , Quality of Life
13.
Article in English | WPRIM | ID: wpr-787244

ABSTRACT

OBJECTIVES: We aimed to evaluate the effect of insulin resistance (IR) on serum Intelectin-1 and endocrinological hormones levels in obese and non-obese women with and without polycystic ovary syndrome (PCOS) in Basrah, Iraq.METHODS: From 124 women volunteers, 60 patients with primary and 64 patients with secondary, while 56 normal ovulatory women were taken as controls. Their fasting insulin hormone, intelectin-1, anti-Mullerian hormone, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estradiol (E2) and testosterones (T) were determined by ELISA methods. BMI, glucose and quantitative insulin sensitivity check index as well as IR was determined by the homeostasis model assessment.RESULTS: A significant changes (P<0.05) were seen in the level of homeostasis model assessment-IR, E2 and T. Levels of anti-Mullerian hormone, LH, LH/FSH ratio and prolactin were significantly (P<0.01) increased and level of intelectin-1 and E2/T ratio were significantly (P<0.01) decreased, while quantitative insulin sensitivity check index level was not significantly different (P>0.05) between the patients (1°PCOS and 2°PCOS) and control groups. On the other hand, our data reported that FSH level was significantly (P<0.05) lower in obese and higher in non-obese patients with PCOS as compared to control group.CONCLUSION: Levels of intelectin-1 and endocrinological hormones have significantly associated with body mass index, IR and physical activity in patients and normal groups and the strategies that can modulate levels of these parameters would improve metabolic disarrangements in women with PCOS.


Subject(s)
Anti-Mullerian Hormone , Body Mass Index , Enzyme-Linked Immunosorbent Assay , Estradiol , Fasting , Female , Follicle Stimulating Hormone , Glucose , Gonadal Steroid Hormones , Hand , Homeostasis , Humans , Insulin Resistance , Insulin , Iraq , Luteinizing Hormone , Motor Activity , Polycystic Ovary Syndrome , Prolactin , Volunteers
15.
ABCS health sci ; 44(3): 203-208, 20 dez 2019. tab
Article in English, Portuguese | LILACS | ID: biblio-1047754

ABSTRACT

Durante o climatério, período em que as gônadas femininas cessam sua função, a deficiência de estrógenos, especialmente do estradiol, provoca alterações importantes na cavidade bucal, interferindo em mecanismos inflamatórios, secreção salivar, metabolismo do colágeno, entre outros. Por meio de uma revisão de literatura, esse estudo teve como objetivo, ver a influência das alterações hormonais advindas do período de climatério nos tecidos bucais, proporcionando ao cirurgião dentista informações em relação às consequências e cuidados relacionados a esta fase da vida da mulher. Nesse período, as mulheres tornam-se mais suscetíveis a alterações tais como: osteopenia e osteoporose dos maxilares, hipossalivação, doenças periodontais, entre outros. O tratamento preventivo por meio de remoção de placa, adequação do meio bucal e orientação antes e durante o climatério são os melhores meios de minimizar os problemas bucais advindos dessa fase da vida da mulher.


During the climacteric period, when female gonads cease their function, estrogen deficiency, especially estradiol, causes important changes in the oral cavity, interfering in inflammatory mechanisms, salivary secretion, collagen metabolism, among others. Through a literature review, this study aimed to see the influence of the hormonal changes from the climacteric period in the oral tissues, providing the dentist surgeon with information regarding the consequences and care related to this phase of the woman's life. In this period, women become more susceptible to changes such as: osteopenia and osteoporosis of the jaws, hyposalivation, periodontal diseases, among others. Preventive treatment through removal of plaque, adequacy of the buccal environment and orientation before and during climacteric are the best means of minimizing oral problems arising from this phase of a woman's life.


Subject(s)
Humans , Female , Gonadal Steroid Hormones , Climacteric , Oral Health , Estradiol , Estrogens
16.
Cambios rev. méd ; 18(2): 72-79, 2019/12/27. graf., tab.
Article in Spanish | LILACS | ID: biblio-1099677

ABSTRACT

INTRODUCCIÓN. En el paciente crítico ha existido un conglomerado de situaciones dadas por alteración de las hormonas acorde al comportamiento del eje hipotalámi-co-hipofisario- gonadal, entender su rol es fundamental. OBJETIVO. Describir las alteraciones de las hormonas sexuales en el paciente críticamente enfermo desde un enfoque fisiológico y clínico. MATERIALES Y MÉTODOS. Estudio observacional, de revisión bibliográfica y análisis sistemático de 84 artículos científicos y selección de muestra de 27 en MedLine, The Cochrane Library Plus, LILACS y Web of Science; en español e inglés y variables: hormonas esteroides gonadales, enfermedad crítica, endocrinología, estrés, gónadas y disfunción, periodo 1998-2017. CONCLUSIÓN. Las alteraciones detectadas fueron un mecanismo para la producción de hormonas esteroideas hacia la síntesis predominante de cortisol y soportar el alto estrés meta-bólico de los pacientes. Las citocinas pro inflamatorias fueron importantes en éstos cambios. La polifarmacia fue un factor adicional poco ponderado de la alteración endocrina sexual.


INTRODUCTION. In the critical patient there has been a conglomerate of situations given by alteration of the hormones according to the behavior of the hypothalamic-pi-tuitary-gonadal axis, understanding their role is fundamental. OBJECTIVE. Describe the alterations of sex hormones in the critically ill patient from a physiological and clinical approach.MATERIALS AND METHODS.Observational, literature review and systematic analysis of 84 scientific articles and sample selection of 27 in MedLine, The Cochrane Library Plus, LILACS and Web of Science; in Spanish and English and variables: gonadal steroid hormones, critical illness, endocrinology, stress, gonads and dysfunction, period 1998-2017. CONCLUSION. The alterations detected were a mechanism for the production of steroid hormones towards the predominant syn-thesis of cortisol and withstand the high metabolic stress of the patients. Pro inflam-matory cytokines were important in these changes. Polypharmacy was an additional unweighted factor of sexual endocrine disruption.


Subject(s)
Humans , Male , Female , Stress, Physiological , Thyroid Hormones , Critical Illness , Endocrinology , Amenorrhea , Gonadal Disorders , Oligospermia , Progesterone , Reproductive and Urinary Physiological Phenomena , Sexual Dysfunction, Physiological , Gonadal Steroid Hormones , Testosterone , Hydrocortisone , Convalescence , Cytokines , Adrenocortical Hyperfunction , Muscle Weakness , Selective Estrogen Receptor Modulators , Deep Sedation , Asexuality , Hypothalamo-Hypophyseal System , Intensive Care Units
17.
Rev. Salusvita (Online) ; 38(3): 665-683, 2019.
Article in Portuguese | LILACS | ID: biblio-1051609

ABSTRACT

Introdução: A infertilidade é definida como incapacidade de gerar filhos e acomete significativa parte da população. Por afetar a qualidade de vida da paciente, a mesma geralmente busca tratamentos que, em suma, são a base de reposição hormonal, que possui diversos efeitos colaterais, abrindo assim uma porta para o estudo de tratamentos alternativos, como o caso das plantas medicinais. Objetivo: Dosar testosterona, progesterona e estradiol em camundongos, assim como sua variação ponderal mediante a suplementação com Tribulus terrestris L. Métodos: Foram utilizados 28 camundongos suíços fêmeas divididas em 4 grupos, sendo dois controles com e sem suplementação e dois que sofreram o processo de ovariectomia bilateral, com e sem suplementação. O extrato da planta foi administrado por 21 dias por gavagem. Os animais foram pesados semanalmente e após os 21 dias foram eutanasiados, e tiveram o sague coletado para as dosagens hormonais. Resultados: Ocorreu queda significativa de testosterona nos grupos suplementados com a planta e nos grupos ovariectomizados em relação ao grupo controle. Em relação ao estradiol, não houve alterações significativas entre os grupos, enquanto a progesterona reduziu significativamente nos grupos castrados com e sem suplementação. Quanto à variação ponderal, ao comparar os grupos ovariectomizados e não ovariectomizados, notou-se aumento significativo do peso. Conclusão: A castração promoveu o aumento de peso nos animais. A mesma medida associada à suplementação reduziu a testosterona e a progesterona sérica, e não alterou os níveis de estradiol nos animais.


Introduction: Infertility is defined as the inability to generate children, and affects a significant part of the population. Because it affects the quality of life of the patient, they usually seeks treatments that, in short, are based on hormonal replacement, which has several side effects, opening, thus, a door for the study of alternative treatments, such as the case of medicinal plants. Objective: To measure testosterone, progesterone and estradiol in mice, as well as their weight variation by means of supplementation with Tribulus terrestris L. Methods: Twenty-eight female Swiss mice were divided into four groups, two controls with and without supplementation and two that underwent the process of bilateral ovariectomy, with and without supplementation. The plant extract was administered for 21 days by gavage. The animals were weighed weekly and, after 21 days, were euthanized and the sage was collected for the hormonal dosages. Results: There was a significant fall in testosterone in the groups supplemented with the plant and in the ovariectomized groups in relation to the control group. There were no significant changes in estradiol between groups, whereas progesterone significantly decreased in the castrated groups with and without supplementation. Regarding the weight variation when comparing the ovariectomized and non-ovariectomized groups, a significant increase in weight was observed. Conclusion: Castration promoted weight gain in animals. The same associated with supplementation reduced testosterone and serum progesterone and did not alter estradiol levels in the animals.


Subject(s)
Mice , Gonadal Steroid Hormones , Ovariectomy
18.
Article in English | WPRIM | ID: wpr-762557

ABSTRACT

BACKGROUND: Follicle-stimulating hormone (FSH), a gonadotropin secreted by the pituitary gland, is a representative secondary sex hormone and an important indicator of reproductive function. The effects of heavy metals such as lead, cadmium, and mercury on humans have been studied, but reports on their effects on sex hormone levels are lacking. Therefore, we investigated the relationship between heavy metal exposure and FSH levels in Korean men and postmenopausal women. METHODS: A total of 4,689 adults (2,763 men and 1,926 postmenopausal women aged 50 years or over) who participated in the Second Korean National Environmental Health Survey (2012–2014) were included. We compared differences in serum FSH levels by demographic characteristics using the t-test and analysis of variance. Multiple linear regression analysis was used to determine the relationship between the blood levels of lead and mercury and the urine cadmium level, and serum FSH levels. RESULTS: On multiple linear regression analysis, lead exposure was positively associated with serum FSH concentrations in postmenopausal women (β = 2.929, p = 0.019). However, we found no significant association between serum FSH concentration and blood lead and mercury levels, or urine cadmium level, in men. CONCLUSIONS: This study suggests that lead exposure can affect the FSH level in postmenopausal women. Further studies are needed to evaluate the effects of low-dose long-term exposure to heavy metals on sex hormones.


Subject(s)
Adult , Cadmium , Environmental Health , Female , Follicle Stimulating Hormone , Gonadal Steroid Hormones , Gonadotropins , Humans , Linear Models , Male , Metals, Heavy , Pituitary Gland
19.
Article in English | WPRIM | ID: wpr-785717

ABSTRACT

Cancer incidence appears to be increased in both type 1 and type 2 diabetes mellitus (DM). DM represents a risk factor for cancer, particularly hepatocellular, hepatobiliary, pancreas, breast, ovarian, endometrial, and gastrointestinal cancers. In addition, there is evidence showing that DM is associated with increased cancer mortality. Common risk factors such as age, obesity, physical inactivity and smoking may contribute to increased cancer risk in patients with DM. Although the mechanistic process that may link diabetes to cancer is not completely understood yet, biological mechanisms linking DM and cancer are hyperglycemia, hyperinsulinemia, increased bioactivity of insulin-like growth factor 1, oxidative stress, dysregulations of sex hormones, and chronic inflammation. However, cancer screening rate is significantly lower in people with DM than that in people without diabetes. Evidence from previous studies suggests that some medications used to treat DM are associated with either increased or reduced risk of cancer. However, there is no strong evidence supporting the association between the use of anti-hyperglycemic medication and specific cancer. In conclusion, all patients with DM should be undergo recommended age- and sex appropriate cancer screenings to promote primary prevention and early detection. Furthermore, cancer should be screened in routine diabetes assessment.


Subject(s)
Breast , Diabetes Mellitus , Diabetes Mellitus, Type 2 , Early Detection of Cancer , Gastrointestinal Neoplasms , Gonadal Steroid Hormones , Humans , Hyperglycemia , Hyperinsulinism , Incidence , Inflammation , Mass Screening , Mortality , Obesity , Oxidative Stress , Pancreas , Primary Prevention , Risk Factors , Smoke , Smoking
20.
Article in Korean | WPRIM | ID: wpr-766608

ABSTRACT

In the ranking of cancer incidence in the year, female breast cancer was the highest cancer after thyroid cancer in 2004–2015, and became the most common cancer in 2016, exceeding the cases of thyroid cancer. The incidence rates of breast cancer have increased steadily over the past two decades and are expected to continue to increase in the next decades, although the incidence rates of all other cancers has declined in Korea. Most of the established risk factors of breast cancer are primarily related to female sex hormones. Other known risk factors are alcohol drinking, a family history of breast cancer, genetic predisposition, and benign breast conditions. Some risk factors, such as physical activity, breastfeeding, and number of children, are modifiable factors that can be targeted for risk reduction. This article summarizes the descriptive epidemiological characteristics of breast cancer in Korea that have been reported and identifies the specific characteristics and secular trends in incidence, mortality, and survival rates of breast cancer up to the present day. It is uncertain whether the risk factors established in western populations will also be valid for the Korean population. To explore this question, we summarize the results from international collaborative studies and meta-analyses of risk factors of breast cancer published to date. The results for Koreans are summarized and described based on results from population-based or nested case-control studies, hospital case-community control studies, cohort studies, and meta-analyses conducted in Korea. This study will be helpful for risk assessment, interventions, and prevention of breast cancer.


Subject(s)
Alcohol Drinking , Breast Feeding , Breast Neoplasms , Breast , Case-Control Studies , Child , Cohort Studies , Epidemiology , Female , Genetic Predisposition to Disease , Gonadal Steroid Hormones , Humans , Incidence , Korea , Mortality , Motor Activity , Risk Assessment , Risk Factors , Risk Reduction Behavior , Survival Rate , Thyroid Neoplasms
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