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1.
Medicina (B.Aires) ; 78(5): 305-310, oct. 2018. ilus, tab
Article in Spanish | LILACS | ID: biblio-976118

ABSTRACT

Los tumores del tronco cerebral son infrecuentes en la población adulta. Las controversias surgen cuando se considera la necesidad de confirmar el diagnóstico histopatológico en esta área elocuente del cerebro, balanceando los beneficios de obtener un diagnóstico certero y las desventajas de los procedimientos invasivos. Existen escasas publicaciones acerca de su tratamiento quirúrgico en adultos, todas series pequeñas analizadas retrospectivamente. Presentamos nuestra experiencia con el propósito de contribuir al proceso de toma de decisiones. Diez de 13 pacientes fueron intervenidos. Las lesiones se clasificaron en focales (n:7), infiltrativa difusa (n:1), tectal (1) y exofítica (1). El estado neurológico según la escala Karnofsky Performance Status fue ≥ 70 en 6 casos y < 70 en 7. Las muestras fueron obtenidas mediante abordaje microquirúrgico directo o por biopsia estereotáctica. Los hallazgos histopatológicos fueron confirmados en todos los casos: astrocitoma pilocítico (n:1), glioma de bajo grado (n:1), glioblastoma (n:1), hemangioblastoma celular (n:1), subependimoma (n:1), disgerminoma (n:1), y lesiones pseudotumorales (n:4, 3 cavernomas, 1 pseudotumor inflamatorio). La amplia variedad de hallazgos patológicos en esta localización en adultos exige una precisa definición histopatológica, que no solo determina la terapéutica adecuada sino que también previene las consecuencias potencialmente catastróficoas de los tratamientos empíricos.


Brainstem tumors are uncommon beyond childhood. Controversies arise regarding the need of histological diagnosis in this eloquent area of the brain, weighting the benefits of a reliable diagnosis against the disadvantages of invasive procedures. There are scant publications about the surgical management of brainstem tumors in adults, all of them involving small retrospective cohorts. We are reporting our experience with the aim of contributing to the decision making process. Out of a series of 13 patients, 10 were approached surgically. According to Guillamo´s classification the lesions were: focal (n:7), diffuse infiltrative (n:1), tectal (n:1), and exophytic (n:1). According to the Karnofsky Performance Status scale, the neurological status was ≥ 70 in 6 cases and < 70 in 7. Histopathology was confirmed in all 10 treated cases and the samples were obtained by a direct microsurgical approach or by stereotactic biopsy. Histopathological findings were: pilocytic astrocytoma (n:1), low grade glioma (n:1), glioblastoma (n:1), cellular haemangioblastoma (n:1), subependimoma (n:1), pseudotumoral lesions (n:4; 3 cavernomas, 1 inflammatory pseudotumor), and disgerminoma (n:1). As a broad variety of pathologies could be found in this brain localization, an accurate histopathological definition can not only determine the adequate therapy, but also avoid the disastrous consequences of empiric treatments.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Brain Stem Neoplasms/surgery , Brain Stem Neoplasms/pathology , Biopsy , Magnetic Resonance Imaging , Cerebral Angiography/methods , Retrospective Studies , Karnofsky Performance Status , Hemangioblastoma/diagnosis , Hemangioma, Cavernous, Central Nervous System/surgery , Hemangioma, Cavernous, Central Nervous System/diagnosis , Brain Stem Neoplasms/diagnosis , Glioma/diagnosis , Granuloma, Plasma Cell/diagnosis
2.
Article in Spanish | LILACS | ID: biblio-908138

ABSTRACT

El pseudotumor inflamatorio (PTI) es una entidad no neoplásica, de etiología desconocida, caracterizada por la proliferación de un infiltrado inflamatorio policlonal sobre un estroma de tejido conjuntivo. Pueden ser definidos como lesiones que clínica y radiológicamente simulan neoplasias. El pseudotumor inflamatorio puede causar dolor facial, obstrucción nasal, exoftalmos y discapacidad visual y con frecuencia causa la erosión y destrucción ósea. Los corticoesteroides, la radioterapia y la cirugía se han utilizado como modalidades de tratamiento, solos o en combinación.


The inflammatory pseudotumour (IPT) is a nonneoplastic entity of unknown origin, and is characterised by a proliferation of connective tissue and a polyclonal inflammatory infiltrate. May be defined as lesions that clinically and radiologically simulate neoplasms. Inflammatory pseudotumour sometimes causes facial pain, nasal obstruction, exophthalmos and visual impairment, and often causes bone erosion and destruction. Corticosteroids, radiotherapy and surgery have been used as treatment modalities either on their own or in combination.


O pseudo-tumor inflamatório (PTI) é uma entidade não neoplásica de etiologia desconhecida, caracterizada pela proliferação de um infiltrado inflamatório policlonal em um estroma do tecido conjuntivo. Podem ser definidos como lesões que simulam neoplasias clínica e radiologicamente. O pseudo-tumor Inflamatório pode causar dor facial, obstrução nasal, exoftalmia (olhos saltados), deficiência visual e freqüentemente provoca o desgaste e a destruição óssea. Os cortiçoesteroides, a radioterapia e a cirurgia têm sido usadas como modalidades de tratamento, por si só ou em combinação.


Subject(s)
Male , Humans , Middle Aged , Granuloma, Plasma Cell/diagnosis , Granuloma, Plasma Cell/surgery , Epistaxis/therapy , Natural Orifice Endoscopic Surgery , Paranasal Sinus Neoplasms/diagnosis , Paranasal Sinus Neoplasms/pathology , Paranasal Sinus Neoplasms/surgery
3.
Rev. chil. infectol ; 32(6): 703-705, ilus
Article in Spanish | LILACS | ID: lil-773277

ABSTRACT

Introduction: Fasciola hepatica is a parasite of the class Trematoda. It commonly has been found in developing countries. When it infects humans is characterized by a triad of fever, pain in right upper quadrant and peripheral eosinophilia. We present a 67-year-old female from a rural town of the north of Lima, Peru, it was found abdominal pain, eosinophilia and focal hepatic lesions. For this reason, a hepatic mass was the initial suspicion. The hepatic biopsy was performed and one of the findings was eosinophilia. Fasciola hepatica infection should be considered as part of differential diagnosis in hepatic tumors with eosinophilia when the origin of the patient is from endemic areas of F. hepatica.


Fasciola hepática es un parásito de la clase Trematoda común en países en desarrollo. La infección en el ser humano se caracteriza por la triada de fiebre, dolor abdominal en el cuadrante superior derecho y eosinofilia. Se presenta el caso de una mujer de 67 años procedente de una zona rural al norte de Lima, con historia de dolor abdominal de seis meses de evolución, con una imagen hipodensa hepática en el TAC abdominal y eosinofilia. La biopsia hepática mostró un infiltrado inflamatorio con eosinofilia. En el diagnóstico diferencial en pacientes con un tumor hepático y eosinofilia, se deben incluir infecciones parasitarias como F. hepatica; sobre todo en pacientes que proceden de áreas endémicas.


Subject(s)
Aged , Animals , Female , Humans , Fasciola hepatica , Fascioliasis/diagnosis , Granuloma, Plasma Cell/parasitology , Biopsy , Diagnosis, Differential , Fascioliasis/drug therapy , Granuloma, Plasma Cell/diagnosis , Tomography, X-Ray Computed
5.
Article in English | IMSEAR | ID: sea-159362

ABSTRACT

Renal replacement lipomatosis (RRL) is a rare benign condition of the kidney in which there is proliferation of fat within renal sinus, hilum and peri-renalspace, thus replacing the renal parenchyma. The pathogenesis of RRL is unknown, although it is generally associated with aging, renal atrophy, long-standing chronic urinary infections. We report two cases of RRL, one of right kidney and other left, both of them associated with kidney stones. The patients were 45 and 65 years old respectively andwere admitted with fever and pain in abdomen. Autopsy performed showed right RRL associated with staghorn calculus and pulmonary tuberculosis in the first patient and left RRL with renal calculus in the pelvis and left pyelonephritis with perinephric abscess and right sided pyelonephritis in the second patient.


Subject(s)
Autopsy , Aged , Female , Granuloma, Plasma Cell/diagnosis , Humans , Kidney Calculi/diagnosis , Kidney Calculi/diagnosis , Kidney Diseases/diagnosis , Lipomatosis/diagnosis , Male , Middle Aged , Pyelonephritis/diagnosis , Tuberculosis, Pulmonary/diagnosis
6.
Asia Oceania Journal of Nuclear Medicine and Biology. 2014; 2 (2): 138-142
in English | IMEMR | ID: emr-167759

ABSTRACT

An inflammatory pseudotumor [IPT] is a rare benign lesion, characterized by nonneoplastic proliferation of inflammatory cells and presence of intermingling collagen fibers. IPT commonly occurs in the lungs and orbita, while an intraspinal IPT is extremely rare. IPT can mimic both clinically and radiologically malignant processes, and making a definitive preoperative diagnosis is often difficult. Recently, 18-fluorine fluorodeoxyglucose [[18]F-FDG] has been reported to accumulate in IPT in the lung, spleen, liver, pancreas, colon, orbit, mediastinum, and mesentery. However, to the best of our knowledge, accumulation of [18]F-FDG has not been reported in lumbosacral intraspinal IPT. Herein, we report a case of IPT in the epidural space of the lumbar spine, using the imaging findings of [18]F-FDG positron emission tomography-computed tomography [PET/CT] and contrastenhanced magnetic resonance imaging [MRI]. This is the first case of IPT in the epidural space, depicted by [18]F-FDG PET/CT, which revealed a homogeneous, intense [18]F-FDG uptake


Subject(s)
Humans , Male , Granuloma, Plasma Cell/diagnosis , Epidural Space , Lumbosacral Region , Spine , Positron-Emission Tomography , Tomography, X-Ray Computed
8.
Gut and Liver ; : 58-63, 2014.
Article in English | WPRIM | ID: wpr-36652

ABSTRACT

BACKGROUND/AIMS: Inflammatory pseudotumor (IPT) of the liver is a rare disease characterized by chronic infiltration of inflammatory cells. However, the clinical characteristics and outcomes of IPT remain uncertain. METHODS: Clinical features, image findings, and outcomes of 55 patients with histologically proven IPT were evaluated. RESULTS: They consisted of 26 men and 19 women with median age of 65 years. Serum carcinoembryonal antigen and carbohydrate antigen 19-9 levels were normal in 42 patients (93.3%). Enhanced CT scans indicated poorly defined peripheral enhancement (82.5%) at the arterial phase and poorly defined hyperattenuating lesions with internal hypoattenuating areas at the equilibrium phase (77.0%). Gadolinium-enhancement MRI revealed poorly defined peripheral rim-like enhancement (77.8%). Ten patients underwent surgical resection and 35 were treated conservatively with or without antibiotics. No recurrence was noted after surgical resection during follow-up (1 to 48 months). In all patients who received conservative treatment, complete resolution or size reduction was noted during follow-up (1 to 192 months). CONCLUSIONS: CT and MRI provide clues to the diagnosis of IPT in patients with liver masses and normal tumor markers. However, due to the lack of pathognomonic findings, the clinician's suspicion and histological diagnosis are necessary to make an accurate diagnosis of IPT.


Subject(s)
Adult , Aged , Aged, 80 and over , Contrast Media , Female , Granuloma, Plasma Cell/diagnosis , Humans , Liver Diseases/diagnosis , Magnetic Resonance Imaging/methods , Male , Middle Aged , Prognosis , Tomography, X-Ray Computed/methods
10.
Acta gastroenterol. latinoam ; 43(1): 48-52, 2013 Mar.
Article in Spanish | LILACS, BINACIS | ID: biblio-1157347

ABSTRACT

Inflammatory pseudo-tumor of the liver is a rare benign condition. Usually presented as a large liver mass, may cause obstruction or infiltration of the main vessels or biliary tree. The clinical presentation is mostly an inflammatory syndrome with acute abdominal pain. We present a 39-year-old female patient with abdominal pain, fever and jaundice. Images showed a 15-cm liver lesion in the left lobe of the liver. Malignancy could not be discarded and the patient underwent left hepatectomy. The histologic examination reported an inflammatory pseudo-tumor of the liver. The patient recurred after one year with the same symptoms and a 10-cm new lesion occupying segment I. Considered as a recurrence, medical treatment was decided tumor size decreased 50


after the first month and completely disappeared during the follow up. Two years later, the patient was readmitted with a new episode and a new 8-cm liver lesion in segment VII. She was treated again with anti-inflammatory medication and imaging control. Although inflammatory pseudo-tumor of the liver is a benign condition, it can have a recurrent behaviour. The differentiation with other malignant tumors sometimes is impossible by clinical and imaging presentation.


Subject(s)
Granuloma, Plasma Cell/diagnosis , Liver Diseases/diagnosis , Adult , Female , Granuloma, Plasma Cell/surgery , Hepatectomy , Humans , Magnetic Resonance Imaging , Recurrence , Tomography, X-Ray Computed
11.
Article in English | WPRIM | ID: wpr-72360

ABSTRACT

Mediastinal inflammatory pseudotumor is a rare benign disease with its capability for local invasion and rapid growth. We present a case of middle-mediastinal inflammatory pseudotumor and report its contrast-enhanced chest computed tomography, 18F-fluorodeoxyglucose positron emission tomography/computed tomography and pathologic findings.


Subject(s)
Adult , Diagnosis, Differential , Fluorodeoxyglucose F18 , Granuloma, Plasma Cell/diagnosis , Humans , Male , Mediastinal Diseases/diagnosis , Positron-Emission Tomography/methods , Radiopharmaceuticals , Tomography, X-Ray Computed/methods
12.
Article in English | IMSEAR | ID: sea-140190

ABSTRACT

Plasma cells are medium-sized round-to-oval cells with eccentrically placed nuclei, usually found in the red pulp of the spleen, tonsils, medulla of the lymph nodes, nasal mucosa, upper airway, lamina propria of the gastrointestinal tract, and sites of inflammation. Plasma cell granuloma is a rare reactive tumor-like proliferation composed chiefly of plasmacytic infiltrate. Here, we present a case of plasma cell granuloma of lip in a female patient.


Subject(s)
Biopsy , Diagnosis, Differential , Female , Granuloma, Plasma Cell/diagnosis , Humans , Lip Diseases/diagnosis , Middle Aged , Oral Ulcer/diagnosis , Plasma Cells/pathology , Stomatitis/diagnosis
13.
Article in English | WPRIM | ID: wpr-39913

ABSTRACT

Immunoglobulin G4 (IgG4)-related sclerosing disease is a systemic disease characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration in various organs. We described the imaging findings of an IgG4-related inflammatory pseudotumor in the urethra. The urethral mass showed isoattenuation on unenhanced CT images, delayed enhancement on enhanced CT images, iso- to slight hyper-intensity on T1 and T2 weighted magnetic resonance images, diffusion restriction on diffusion weighted images, and heterogeneously low echogeneity on ultrasonography.


Subject(s)
Aged , Autoimmune Diseases/diagnosis , Female , Granuloma, Plasma Cell/diagnosis , Humans , Immunoglobulin G/immunology , Pancreatitis/diagnosis , Sclerosis , Urethral Diseases/diagnosis
14.
Article in English | WPRIM | ID: wpr-130104

ABSTRACT

The term inflammatory pseudotumor (IPT) has been used to describe inflammatory and fibrosing tumoral processes of an undetermined cause that may involve a variety of organ system. IgG4-related disease is a newly recognized fibroinflammatory condition characterized by IgG4-producing plasma cell expansion in affected organs and, often but not always, elevated serum IgG4 concentrations. IgG4-related IPTs, a subtype of IPT, are characterized by dense infiltration of IgG4-positive plasma cells and stromal fibrosis. The association between inflammatory pseudotumor and IgG4 was first reported with a regard to sclerosing pancreatitis. Despite there are many reports on intraperitoneal IPTs including both cellular and lymphoplasmacytic type, only a few cases have been confirmed to be IgG4-related. We experienced a case of intraperitoneal IgG4-related inflammatory pseudotumor in an 83-year-old woman presenting with epigastric pain and malaise. Surgical specimens revealed an IgG4-related inflammatory pseudotumor.


Subject(s)
Aged, 80 and over , C-Reactive Protein/analysis , Female , Granuloma, Plasma Cell/diagnosis , Humans , Immunoglobulin G/blood , Plasma Cells/metabolism , Positron-Emission Tomography , Tomography, X-Ray Computed
15.
Article in English | WPRIM | ID: wpr-130089

ABSTRACT

The term inflammatory pseudotumor (IPT) has been used to describe inflammatory and fibrosing tumoral processes of an undetermined cause that may involve a variety of organ system. IgG4-related disease is a newly recognized fibroinflammatory condition characterized by IgG4-producing plasma cell expansion in affected organs and, often but not always, elevated serum IgG4 concentrations. IgG4-related IPTs, a subtype of IPT, are characterized by dense infiltration of IgG4-positive plasma cells and stromal fibrosis. The association between inflammatory pseudotumor and IgG4 was first reported with a regard to sclerosing pancreatitis. Despite there are many reports on intraperitoneal IPTs including both cellular and lymphoplasmacytic type, only a few cases have been confirmed to be IgG4-related. We experienced a case of intraperitoneal IgG4-related inflammatory pseudotumor in an 83-year-old woman presenting with epigastric pain and malaise. Surgical specimens revealed an IgG4-related inflammatory pseudotumor.


Subject(s)
Aged, 80 and over , C-Reactive Protein/analysis , Female , Granuloma, Plasma Cell/diagnosis , Humans , Immunoglobulin G/blood , Plasma Cells/metabolism , Positron-Emission Tomography , Tomography, X-Ray Computed
16.
J. bras. patol. med. lab ; 47(4): 461-464, ago. 2011. ilus
Article in Portuguese | LILACS | ID: lil-599780

ABSTRACT

Os pseudotumores fibrosos são lesões incomuns que ocorrem geralmente em resposta a cirurgia, trauma, infecção ou inflamação. Relatamos um caso de paciente com 25 anos de idade que apresentou massa escrotal indolor. Realizou-se orquiectomia radical. O diagnóstico anatomopatológico foi de pseudotumor fibroso do cordão espermático.


Fibrous pseudotumors are uncommon lesions that mostly occur in response to surgery, trauma, infection or inflammation. We report the case of 25 year-old patient, who presented painless scrotal mass. A total orchidectomy was performed. The anatomopathological diagnosis was fibrous pseudotumor of the spermatic cord.


Subject(s)
Humans , Male , Young Adult , Spermatic Cord/pathology , Granuloma, Plasma Cell/diagnosis
17.
Iranian Journal of Pediatrics. 2011; 21 (4): 543-548
in English | IMEMR | ID: emr-137376

ABSTRACT

The Abdominal Inflammatory Myofibroblastic Tumor [AIMT] is a rare tumor with unknown etiology which usually occurs in children and adolescents. It is composed of myofibroblastic spindle cells intermixed with inflammatory cells. We present four cases of AIMT. We herein present four cases of AIMT in different ages [range: 3.5 to 13 years] and in different organs [stomach, periduodenal, mesenteric, and colon]. There were two females and two males. The main symptoms were abdominal pain/mass/obstruction, vomiting, and weight loss. In all four patients, diagnosis was made by laparatomy and pathologic examination of excised mass lesion. Three patients underwent complete excision and no residual disease was present, one patient received chemotherapy due to tumor recurrences. The patients were followed up in average for four years. As the imaging and laboratory tests are non-specific, the diagnosis of AIMT is rarely made before surgery. AIMT should, therefore, be considered when a mass arises in an unusual location in the pediatric age group. Complete surgical resection should be performed whenever possible and the child should be kept on long-term follow-up


Subject(s)
Humans , Male , Female , Abdominal Neoplasms/pathology , Abdominal Neoplasms/surgery , Granuloma, Plasma Cell/diagnosis , Review Literature as Topic
18.
Neumol. pediátr ; 6(2): 95-99, 2011. ilus, tab
Article in Spanish | LILACS | ID: lil-708211

ABSTRACT

Primary lung tumours in children are rare, the most common lesions seen in clinical practice are metastatic disease. The majority of children who present with a primary or secondary pulmonary malignancy will present coincidentally while seeking attention for another medical problem, or with non-specific abnormalities such as cough with collapse or consolidation on the chest x-ray. Primary malignant tumours of the lung are the most common, this group is made up of carcinoid tumours, bronchogenic carcinoma and pleuropulmonary blastoma. Benign primary pulmonary tumours are inflammatory pseudotumour or plasma cell granuloma and hamartoma. Often, the possibility of a primary or secundary pulmonary tumour is considered only when radiographic abnormalities or symptoms persist or fail to respond to therapy, many children are asymptomatic until they have advanced disease, which delays diagnosis even further. The aim of this article is show our experience of two patients with inflammatory pseudotumour and literature review.


Los tumores pulmonares primarios en niños son muy poco frecuentes, siendo más reportadas las lesiones metátasicas. La mayoría de los pacientes que presentan un tumor pulmonar ya sea primario o secundario, son hallazgos de algún examen generalmente imagenológico, como parte del estudio de otras causas o en presencia de síntomas inespecíficos como tos asociada a atelectasia o condensación. Los tumores pulmonares primarios malignos son los más frecuentes, comprenden el tumor carcinoide, carcinoma broncogénico y blastoma pleuropulmonar. Los tumores pulmonares primarios benignos son el seudotumor inflamatorio (sTi) o granuloma de células plasmáticas y el hamartoma. Se debe tener un alto índice de sospecha en el diagnóstico de tumor pulmonar primario o secundario, frente a la persistencia de síntomas o si presenta una lesión en la radiografía de tórax que no se modifica o invade localmente a otros tejidos adyacentes a pesar del tratamiento. El objetivo de este artículo es mostrar nuestra experiencia de 2 pacientes portadores de sTi y hacer una revisión de la literatura.


Subject(s)
Humans , Male , Female , Infant, Newborn , Child , Lung Diseases/surgery , Lung Diseases/diagnosis , Granuloma, Plasma Cell/surgery , Granuloma, Plasma Cell/diagnosis , Myofibroblasts , Lung Neoplasms/classification , Pneumonectomy
19.
Article in English | IMSEAR | ID: sea-139903

ABSTRACT

Plasma cell granuloma is a rare reactive lesion composed of polyclonal plasma cells. It manifests primarily in the lungs, but may occur in various other anatomic locations like the oral cavity. Intraoral plasma cell granulomas involving the tongue, lip, oral mucosa and gingiva have been reported in the past. This case presents a 54-year-old female with chronic periodontitis and mandibular anterior gingival overgrowth treated by Phase I therapy (scaling and root planing) and excisional biopsy. Histological examination revealed inflammatory cell infiltrate containing sheets of plasma cells. Immunohistochemistry for kappa and lambda light chains showed a polyclonal staining pattern confirming a diagnosis of plasma cell granuloma. This case highlights the need to biopsy for unusual lesions to rule out potential neoplasms.


Subject(s)
Chronic Periodontitis/diagnosis , Diagnosis, Differential , Female , Gingival Diseases/diagnosis , Gingival Diseases/pathology , Gingival Overgrowth/diagnosis , Granuloma, Plasma Cell/diagnosis , Granuloma, Plasma Cell/pathology , Humans , Immunoglobulin kappa-Chains/analysis , Immunoglobulin lambda-Chains/analysis , Middle Aged
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