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1.
Rev. Assoc. Med. Bras. (1992) ; 66(1): 74-80, Jan. 2020. tab, graf
Article in English | LILACS | ID: biblio-1091899

ABSTRACT

SUMMARY OBJECTIVE This study aims to investigate the application value of magnetic resonance (MR) hydrography of the inner ear in cochlear implantation. METHODS 146 patients were enrolled. MR hydrography and spiral CT examinations for the intracranial auditory canal were performed before surgery, and all imaging results were statistically analyzed in order to explore the application value of MR hydrography of the inner ear in cochlear implantation. RESULTS 146 patients (292 ears) were examined. Among these patients, 13 were diagnosed with abnormal vestibular aqueducts (20 ears) by MR hydrography, while five were diagnosed with this disease by CT; 15 patients were diagnosed with inner ear malformation (19 ears) by MR hydrography, while 11 were diagnosed by CT (four were misdiagnosed); five patients were diagnosed with internal acoustic canal stenosis (eight ears) by MR hydrography, while two were diagnosed by CT (three were misdiagnosed); and four patients were diagnosed with cochlear fibrosis (five ears) by MR hydrography, while four were diagnosed by CT (four ears). The correct rate of diagnosis was 77.40% (113/146) based on CT, while the rate was 93.84% (137/146) based on MR hydrography. CONCLUSIONS MR hydrography imaging technique can be applied to the preoperative evaluation of cochlear implantation, providing accurate and reliable anatomic information on the inner membranous labyrinth and nerves in the internal acoustic canal and an accurate basis for the diagnosis of cochlear fibrosis and nerve development. This has a guiding significance for the selection of treatment schemes.


RESUMO OBJETIVO Este estudo visa investigar o valor da aplicação da hidrografia por ressonância magnética (RM) do ouvido interno no implante coclear. MÉTODOS Cento e quarenta e seis pacientes foram inscritos. Os exames da hidrografia por RM e do CT espiral para o canal auditivo intracraniano foram executados antes da cirurgia, e todos os resultados da imagem foram analisados estatisticamente, a fim de explorar o valor da aplicação da hidrografia por RM do ouvido interno no implante coclear. RESULTADOS Centro e quarenta e seis pacientes (292 ouvidos) foram examinados. Dentre esses pacientes, 13 foram diagnosticados com aquedutos vestibulares anormais (20 ouvidos) pela hidrografia por RM, enquanto cinco pacientes foram diagnosticados com esta doença pelo CT; 15 pacientes foram diagnosticados com malformação do ouvido interno (19 ouvidos) pela hidrografia por RM, enquanto 11 pacientes foram diagnosticados por CT (quatro foram diagnosticados erroneamente); cinco pacientes foram diagnosticados com estenose de canal acústico interno (oito ouvidos) pela hidrografia por RM, enquanto dois pacientes foram diagnosticados por CT (três foram diagnosticados erroneamente); e quatro pacientes foram diagnosticados com fibrose coclear (cinco ouvidos) pela hidrografia por RM, enquanto quatro foram diagnosticados por CT (quatro ouvidos). A taxa correta de diagnóstico foi de 77,40% (113/146) com base no CT, enquanto a taxa foi de 93,84% (137/146) com base na hidrografia por RM. CONCLUSÕES A técnica de imagem da hidrografia por RM pode ser aplicada à avaliação pré-operatória do implante coclear, que pode fornecer informações anatômicas precisas e confiáveis sobre o labirinto membranoso interno e os nervos no canal acústico interno, além de uma base exata para o diagnóstico da fibrose coclear e do desenvolvimento do nervo. Isso tem um significado orientador para a seleção de esquemas de tratamento.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Young Adult , Magnetic Resonance Imaging/methods , Cochlear Implantation/methods , Ear, Inner/diagnostic imaging , Reference Values , Reproducibility of Results , Tomography, Spiral Computed/methods , Preoperative Period , Hearing Loss, Sensorineural/surgery , Hearing Loss, Sensorineural/diagnostic imaging , Ear, Inner/surgery , Labyrinth Diseases/surgery , Labyrinth Diseases/diagnostic imaging , Middle Aged
2.
Rev. chil. pediatr ; 90(4): 437-442, ago. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1020652

ABSTRACT

INTRODUCCIÓN: Síndrome de Bartter (SB) es una tubulopatía hereditaria, poco frecuente que tiene dos formas de presentación, forma grave de inicio antenatal (Bartter neonatal) y forma de aparición más tardía (Bartter clásico). En su forma antenatal se manifiesta con poliuria fetal, polihidroamnios de inicio precoz y severo, parto prematuro secundario y restricción de crecimiento intrauterino. La etapa postnatal presenta episodios recurrentes de deshidratación y desbalance electrolítico que pue den comprometer la sobrevida del paciente. OBJETIVO: Comunicar un caso de SB neonatal y presentar una revisión de la literatura en esta patología. CASO CLÍNICO: Prematuro 35 semanas, con antecedente de severo polihidroamnios diagnosticado a las 27 semanas de gestación, sin causa aparente. Desde su nacimiento evolucionó con poliuria y alcalosis metabólica hipokalémica haciendo plantear, en primera semana de vida, diagnóstico de Síndrome de Bartter neonatal. El laboratorio confirmó per didas urinarias de electrólitos. Fue manejado con balance hídrico estricto y suplementación de sodio y potasio, logrando estabilizar peso y desbalance electrolítico. Se mantiene en control nefrológico, con suplementación de gluconato de potasio y cloruro de sodio. Se agregó ibuprofeno al cuarto mes como parte del tratamiento. Al séptimo mes de vida, ecografía renal demostró nefrocalcinosis. Al año de vida se evidenció hipoacusia sensorioneural profunda requiriendo implante coclear. CONCLUSIÓN: Presencia de polihidroamnios severo de aparición temprana sin causa identificada debe hacer sospechar SB, que aun siendo infrecuente determina graves alteraciones hidroelectrolíticas y debe ser iniciado su tratamiento precozmente.


INTRODUCTION: Bartter syndrome (BS) is a rare inherited tubulopathy that has two presentation forms, the first one is a severe form of antenatal onset (neonatal Bartter) and the second one is a later on set form during the first years of life (classic Bartter). In the antenatal form, it manifests with fetal polyuria, polyhydramnios of early and severe onset, premature delivery, and intrauterine growth restriction. In the postnatal stage, it presents recurrent episodes of dehydration and electrolyte im balance that can compromise the survival of the patient. OBJECTIVE: To report a clinical case of neo natal BS and a review of the literature. CLINICAL CASE: Premature newborn of 35 weeks of gestation with history of severe polyhydramnios diagnosed at 27 weeks of gestation, without apparent cause. From birth, the patient presented polyuria and hypokalemic metabolic alkalosis making a diagnosis of Neonatal Bartter Syndrome in the first week of life. Laboratory tests confirmed urinary electrolyte losses. The patient was treated with strict water balance and sodium and potassium supplementa tion, achieving weight and electrolyte imbalance stabilization. The patient remains in control in the nephrology unit, with potassium gluconate and sodium chloride supplementation. At the fourth month, ibuprofen was added as part of treatment. At the seventh month of life, renal ultrasound showed nephrocalcinosis. At one year of life, profound sensorineural hearing loss was observed re quiring a cochlear implant. CONCLUSION: The presence of severe polyhydramnios of early onset with no identified cause should lead to suspicion of neonatal BS which even when infrequent determines severe hydroelectrolytic alterations and should be treated early.


Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Infant , Adult , Bartter Syndrome/diagnosis , Polyhydramnios/diagnosis , Bartter Syndrome/physiopathology , Bartter Syndrome/therapy , Ibuprofen/administration & dosage , Polyhydramnios/etiology , Hearing Loss, Sensorineural/surgery , Hearing Loss, Sensorineural/diagnosis , Nephrocalcinosis/diagnosis , Nephrocalcinosis/etiology
3.
Int. j. morphol ; 35(2): 413-419, June 2017. ilus
Article in English | LILACS | ID: biblio-892996

ABSTRACT

Surgical techniques for treatment of sensory neural hearing loss (SNHL) have unpredictable outcomes and in recent years cell therapy investigated for treatment of SNHL. Olfactory epithelium proceed neurogenesis during life time and provide an easily accessible source of neural stem cells. So the aim of this study was isolating neural stem cells from olfactory epithelium of rat and differentiation of these cells into hair cells of inner ear in vitro. The epithelium tissue of olfactory mucosa of rats were removed and digested by collagenase H. The digested tissue was cultured in flasks in suspension forms to create spheres. Spheres were passaged and from passage 2 spheres selected for differentiation. At this stage cells of spheres isolated from each other and placed in flask containing defined differentiation medium. Cells at this stage cultured in adhesive form. Immunohistochemistry and RT-PCR were used for neural stem cells and hair cells identification. Spheres formed from olfactory epithelium culture and immunohistochemistry revealed that cells of spheres from passage one and two expressed the neural stem cells markers. After culture of isolated cells in differentiation medium, the morphology of cells begun to change. The cells presented neural cells projections and after 10 days the projections elongated more and interact to each other in multi layers. RT-PCR and immunohistochemistry revealed that differentiated cells expressed hair cells specific genes. In this study we showed that neural stem cells of olfactory epithelium can differentiate into hair cells of inner ear and therefore can be used for treatment of SNHL.


Las técnicas quirúrgicas para el tratamiento de la pérdida auditiva neural sensorial (PANS) tienen resultados impredecibles y en los últimos años la terapia celular ha sido investigada para su tratamiento. El epitelio olfatorio se forma durante la neurogénesis y proporciona una fuente fácilmente accesible de células madre neurales. El objetivo de este estudio fue aislar las células madre neurales del epitelio olfativo de la rata y la diferenciación de estas células en vestibulocitos del oído interno in vitro. Se retiró el tejido del epitelio de la mucosa olfatoria de ratas y fue digerido con colagenasa H. El tejido se cultivó en forma de suspensión para crear esferas. Se seleccionaron dos esferas para la diferenciación. En esta fase, las células de esferas fueron aisladas unas de otras y colocadas en un medio de diferenciación definido. Células en esta etapa fueron cultivadas en forma adhesiva. Inmunohistoquímica y RT-PCR se utilizó para las células madre neurales y la identificación de células ciliadas. Las esferas formadas a partir del cultivo del epitelio olfatorio y la inmunohistoquímica revelaron que las células de esferas en etapas uno y dos expresaban los marcadores de células madre neurales. Se observaron cambios en la morfología de las células después del cultivo de células aisladas. RT-PCR e inmunohistoquímica revelaron que las células diferenciadas expresaron células específicas de gen de vestibulocitos. Se observó que las células madre neuronales de epitelio olfatorio puede diferenciarse en células en forma de cabello del oído interno y por lo tanto puede ser utilizado para el tratamiento de PANS.


Subject(s)
Animals , Rats , Hearing Loss, Sensorineural/surgery , Neural Stem Cells/transplantation , Olfactory Mucosa/cytology , Cell Differentiation , Immunohistochemistry , Polymerase Chain Reaction , Rats, Sprague-Dawley
4.
Santiago; Chile. Ministerio de Salud; 2017. tab.
Monography in Spanish | LILACS, BRISA | ID: biblio-882319

ABSTRACT

INTRODUCCIÓN: El término compuesto "Hipoacusia Sensorioneural Severa o Profunda" (HSN Severa a Profunda) hace referencia, por una parte, a una condición audiológica de disminución, desde 70 dB - 90 dB (Severa ­ Profunda, respectivamente), en la capacidad auditiva y, por otra, a la localización coclear o retrococlear (nervio auditivo) de un daño o lesión, uni o bilateral (1). La pérdida de audición adquirida o hipoacusia adquirida, es aquella discapacidad auditiva producida después del nacimiento, que incluye a las congénitas de aparición tardía, como por ejemplo la causada por citomegalovirus. En el caso específico de las hipoacusias sensorioneurales (HSN), tanto en niños como adultos, puede presentarse posterior al nacimiento como resultado de: la edad, enfermedad de los vasos sanguíneos, enfermedad inmunitaria, Infecciones, tales como meningitis, paperas, escarlatina y sarampión, ruidos o sonidos fuertes o sonidos fuertes que duran mucho tiempo, enfermedad de Ménière, trauma, tumor, como por ejemplo un neurinoma del acústico, uso de ciertos medicamentos o exposición constante a ruidos, por ejemplo por temas laborales o de forma idiopática. TECNOLOGÍA SANITARIA ANALIZADA: Implante Coclear. EFICACIA DE LOS TRATAMIENTOS: Todas las revisiones sistemáticas presentan resultados positivos en los resultados medidos para el implante coclear, ya sea unilateral o bilateral. A pesar de ésto, el nivel de evidencias es bajo, ya que las revisiones sistemáticas carecen de estudios randomizados, presentando heterogeneidad en sus diseños: estudios de casos, estudios de cohortes prospectivos. La percepción del habla y la calidad de vida mejoran con implantación unilateral y bilateral, especialmente en condiciones de ruidos. El IC bilateral con respecto al IC unilateral ofrece ventajas en la audición en ruido (+++), en la localización sonora (+++) y durante la audición en un entorno silencioso (++). ANÁLISIS ECONÓMICO: A excepción de contextos de países con bajo ingreso, el implante coclear es una intervención costo-efectiva en países de mediano y alto ingreso. Es necesario tener en cuenta que la costoefectividad de la intervención es mayor en personas con hipoacusia post-lingual y disminuye en personas con pérdida de la audición profunda durante un tiempo prolongado. Los resultados de la revisión sistemática que buscó evaluaciones económicas del implante coclear en adultos mostró qué, a pesar de la incertidumbre y la calidad metodológica de los estudios encontrados, la evidencia avala el uso del implante coclear unilateral en adultos. CONCLUSIÓN: Para dar cumplimiento al artículo 28° del Reglamento que establece el proceso destinado a determinar los diagnósticos y tratamientos de alto costo con Sistema de Protección Financiera, según lo establecido en los artículos 7° y 8° de la ley N°20.850, aprobado por el decreto N° 13 del Ministerio de Salud, se concluye que el presente informe de evaluación se considera favorable, de acuerdo a lo establecido en el Título III. De las Evaluaciones Favorables de la Norma Técnica N° 0192 de este mismo Ministerio.


Subject(s)
Humans , Cochlear Implantation/methods , Hearing Loss, Sensorineural/surgery , Health Evaluation/economics , Technology Assessment, Biomedical/economics
5.
Rev. Fed. Argent. Soc. Otorrinolaringol ; 24(3): 53-59, 2017. ilus, tab
Article in Spanish | LILACS | ID: biblio-908155

ABSTRACT

Introducción: la deficiencia del nervio coclear se define como un nervio coclear hipoplásico o aplásico, presente en más del 18% de los niños con hipoacusias neurosensoriales profundas y cuya indicación de implante coclear sigue generando controversias. Objetivo: Analizar el protocolo de estudio en pacientes con sospecha de deficiencia del nervio coclear y exponer los resultados clínico-audiológicos pos-implante coclear en nuestro servicio. Material y método: Estudio retrospectivo de historias clínicas en el período 2011-2017, analizando los estudios solicitados dentro de la evaluación preimplante coclear y el estudio extendido en pacientes con sospecha de deficiencia del nervio coclear. Resultados: Dentro de la población, un caso correspondió a un paciente con hipoacusia neurosensorial profunda bilateral con sospecha de deficiencia del nervio coclear (Birman: GRADO I y Casselman: TIPO I/IIa bilateral). El potencial evocado auditivo de tronco encefálico eléctrico permitió determinar el oído a implantar, mostrando mejor configuración de ondas para el oído derecho. Actualmente, presenta una óptima adaptación al implante (categoría de performance auditivo: 2-categoría de Moog-Geers: 3), con una puntuación de 8/40 en el cuestionario IT-MAIS. Conclusión: El protocolo de estudio prequirúrgico extendido es aplicable a pacientes con sospecha de deficiencia del nervio coclear. Estudios funcionales aportan datos de utilidad para determinar cuál de estos pacientes podrían beneficiarse tras la colocación del mismo. El asesoramiento familiar sobre las limitaciones y los objetivos reales es fundamental.


Introduction: cochlear nerve deficiency is defined as a hypoplastic or aplastic cochlear nerve present in more than 18% of children with profound sensorineural hearing loss. Cochlear implant indication continues to generate controversy. Objective: Analyze the study protocol in patients with suspected cochlear nerve deficiency and expose the clinical-audiological results after cochlear implant in our service. Material and method: Retrospective study of medical records in the period 2011-2017. Analyzing the studies requested within the cochlear pre-implant evaluation and the extended study in patients with suspected cochlear nerve deficiency. Results: Within the population, one case corresponded to a patient with bilateral profound sensorineural hearing loss with suspicion of Cochlear nerve deficiency (Birman GRADE I and Casselman TYPE I/IIa bilateral). The auditory evoked potentials by electrical stimulation allowed to determine the ear to be implanted, showing better configuration of waves for the right ear. Currently, it presents an optimal adaptation to the implant (Auditory per formance category: 2- Category of Moog-Geers: 3), with a score of 8/40 in the IT-MAIS questionnaire. Conclusion: The extended preoperative study protocol is appropriate for patients with suspected cochlear nerve deficiency. Functional studies provide useful data to determine which patients could benefit. Family counseling about real limitations and goals is critical.


Introdução: a deficiência do nervo coclear é definida como um nervo coclear hipoplásico ou aplástico presente em mais de 18% das crianças com perda auditiva neurossensorial profunda onde a indicação do implante coclear continua a gerar polêmica. Objetivo: Analisar o protocolo do estudo em pacientes com suspeita de deficiência do nervo coclear e apresentar os resultados clínico-audiológicos após o implante coclear em nosso serviço. Material e método: Estudo retrospectivo dos registros clínicos no período de 2011-2017, analisando os estudos solicitados na avaliação pré-implante coclear e o estudo prolongado em pacientes com suspeita de deficiência de nervo coclear. Resultados: Dentro da população, um caso correspondeu a um paciente com perda auditiva neurossensorial profunda bilateral com suspeita de deficiência do nervo coclear (Birman: GRADO I e Casselman: TIPO bilateral I/IIa). O potenciais evocados auditivos elétrico permitiu determinar a orelha a ser implantada, mostrando melhor configuração de ondas para a orelha direita. Atualmente, apresenta uma ótima adaptação ao implante (categoria de desempenho auditivo: 2- categoria de Moog-Geers: 3), com uma pontuação de 8/40 no questionário IT-MAIS. Conclusão: O protocolo de estudo pré-operatório estendido é aplicável a pacientes com suspeita de deficiência do nervo coclear. Estudos funcionais fornecem dados úteis para determinar quais pacientes poderiam se beneficiar do implante coclear. O aconselhamento familiar sobre limitações e metas reais é crítico.


Subject(s)
Male , Female , Humans , Adolescent , Adult , Child, Preschool , Child , Young Adult , Middle Aged , Cochlear Nerve , Cochlear Implantation/statistics & numerical data , Cochlear Implantation , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/surgery , Vestibulocochlear Nerve Diseases/diagnosis , Vestibulocochlear Nerve Diseases/surgery
6.
Rev. otorrinolaringol. cir. cabeza cuello ; 76(2): 215-218, ago. 2016. ilus
Article in Spanish | LILACS | ID: lil-793969

ABSTRACT

Presentamos un caso clínico de implante coclear cuya evaluación inicial intraoperatoria fue normal. La normalidad fue evaluada por introducción por ventana oval, respuesta neural y objetivación del reflejo estapedial intraoperatorio. Sin embargo, la objetivación de la correcta implantación en rampa timpánica, con radiología convencional, demostró una sorprendente posición anómala lo que obligó a una reimplantación inmediata con muy buenos resultados. El objetivo de esta comunicación es compartir nuestra experiencia y aconsejar siempre un método radiográfico práctico, rápido y de bajo costo, que permite la evaluación de los electrodos con respecto a su posición y la integridad, durante la inserción de los implantes cocleares.


We report a case of intraoperative cochlear implant whose initial evaluation was normal. Normality was assessed by introduction oval window, neural response and intraoperative objectification of acoustic reflex. However, the objectification of the proper implementation in scala tympani, with conventional radiology, showed a surprising anomalous position which forced an immediate reimplantation with very good results. The purpose of this communication is to share our experience and always advise a practical, fast and radiographic method low cost, which allows assessment of the electrodes with respect to its position and integrity, during insertion of cochlear implants.


Subject(s)
Humans , Female , Middle Aged , Cochlear Implantation/methods , Cochlear Implants , Hearing Loss, Sensorineural/surgery , Electrodes, Implanted , Intraoperative Care , Radiography , Replantation
7.
Braz. j. otorhinolaryngol. (Impr.) ; 82(2): 123-130, Mar.-Apr. 2016. tab, graf
Article in English | LILACS | ID: lil-780987

ABSTRACT

ABSTRACT INTRODUCTION: The cochlear implant device has the capacity to measure the electrically evoked compound action potential of the auditory nerve. The neural response telemetry is used in order to measure the electrically evoked compound action potential of the auditory nerve. OBJECTIVE: To analyze the electrically evoked compound action potential, through the neural response telemetry, in children with bilateral cochlear implants. METHODS: This is an analytical, prospective, longitudinal, historical cohort study. Six children, aged 1-4 years, with bilateral cochlear implant were assessed at five different intervals during their first year of cochlear implant use. RESULTS: There were significant differences in follow-up time (p = 0.0082) and electrode position (p = 0.0019) in the T-NRT measure. There was a significant difference in the interaction between time of follow-up and electrode position (p = 0.0143) when measuring the N1-P1 wave amplitude between the three electrodes at each time of follow-up. CONCLUSION: The electrically evoked compound action potential measurement using neural response telemetry in children with bilateral cochlear implants during the first year of follow-up was effective in demonstrating the synchronized bilateral development of the peripheral auditory pathways in the studied population.


RESUMO INTRODUÇÃO: O implante coclear tem a capacidade de medir o potencial de ação composto eletricamente evocado do nervo auditivo (ECAP). Para esta verificação utiliza-se uma medida chamada telemetria de respostas neurais. OBJETIVO: Analisar o potencial de ação composto evocado eletricamente, por meio da neurotelemetria de respostas neurais, em crianças usuárias de implante coclear bilateral. MÉTODO: Trata-se de um estudo analítico, prospectivo, de coorte histórica longitudinal. Foram recrutadas seis crianças, com idades entre de 1-4 anos, usuárias de implante coclear bilateral. Estas crianças foram avaliadas em cinco momentos durante o primeiro ano de uso do implante coclear. RESULTADOS: Houve diferença significativa no tempo de acompanhamento (p = 0,0082) e posição do eletrodo (p = 0,0019) na medida de T-NRT. Houve diferença significativa na interação entre tempo de acompanhamento e posição do eletrodo (p = 0,0143) na medida da amplitude das ondas N1-P1 entre os três eletrodos a cada tempo de acompanhamento. CONCLUSÃO: A mensuração do ECAP por meio da NRT nas crianças com implante coclear bilateral durante o primeiro ano de acompanhamento foi uma medida importante para apresentar o desenvolvimento bilateral da via auditiva periférica de forma sincronizada nesta população estudada.


Subject(s)
Child, Preschool , Female , Humans , Infant , Male , Cochlear Implants , Cochlear Implantation/rehabilitation , Evoked Potentials, Auditory/physiology , Hearing Loss, Sensorineural/surgery , Action Potentials , Auditory Threshold/physiology , Cochlear Nerve , Prospective Studies , Telemetry
8.
Braz. j. med. biol. res ; 49(4): e5064, 2016. tab, graf
Article in English | LILACS | ID: biblio-951670

ABSTRACT

In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs) are viable after transplantation into the basal turns of neomycin-injured guinea pig cochleas. We also examined the effects of mIESC transplantation on auditory functions. Eight adult female Cavia porcellus guinea pigs (250-350g) were deafened by intratympanic neomycin delivery. After 7 days, the animals were randomly divided in two groups. The study group (n=4) received transplantation of LacZ-positive mIESCs in culture medium into the scala tympani. The control group (n=4) received culture medium only. At 2 weeks after transplantation, functional analyses were performed by auditory brainstem response measurement, and the animals were sacrificed. The presence of mIESCs was evaluated by immunohistochemistry of sections of the cochlea from the study group. Non-parametric tests were used for statistical analysis of the data. Intratympanic neomycin delivery damaged hair cells and increased auditory thresholds prior to cell transplantation. There were no significant differences between auditory brainstem thresholds before and after transplantation in individual guinea pigs. Some mIESCs were observed in all scalae of the basal turns of the injured cochleas, and a proportion of these cells expressed the hair cell marker myosin VIIa. Some transplanted mIESCs engrafted in the cochlear basilar membrane. Our study demonstrates that transplanted cells survived and engrafted in the organ of Corti after cochleostomy.


Subject(s)
Animals , Female , Organ of Corti/surgery , Stem Cells , Stem Cell Transplantation/methods , Hair Cells, Auditory, Inner/transplantation , Hearing Loss, Sensorineural/surgery , Auditory Threshold , Immunohistochemistry , Protein Synthesis Inhibitors , Neomycin , Cell Survival , Cells, Cultured , Reproducibility of Results , Evoked Potentials, Auditory, Brain Stem , Treatment Outcome , Guinea Pigs , Mice, Inbred BALB C
9.
Braz. j. otorhinolaryngol. (Impr.) ; 81(3): 240-247, May-Jun/2015. tab
Article in English | LILACS | ID: lil-751910

ABSTRACT

INTRODUCTION: Auditory rehabilitation in children with bilateral severe-to-profound sensorineural hearing loss with cochlear implant has been developed in recent decades; however, the rehabilitation of children with cerebral palsy still remains a challenge to otolaryngology and speech therapy professionals. OBJECTIVE: To verify the effectiveness of cochlear implants in the development of auditory and language skills in children with cerebral palsy. METHODS: A prospective analytical study. The evaluation of auditory responses to speech test was applied to the children in this study at regular intervals following implantation. Standardized tests that assess and quantify the development of auditory and language skills were administered and speech therapy video records and speech therapy files were analyzed. All children went through individually tailored intensive audiological rehabilitation programs following cochlear implantation. RESULTS: Two participants had gradual auditory and language development when compared to other participants who reached advanced levels in hearing and oral language classifications. CONCLUSION: The use of the Cochlear implant enabled participants to reach advanced stages of hearing and language skills in three of the five participants with cerebral palsy in this study. This electronic device is a viable therapeutic option for children with cerebral palsy to help them achieve complex levels of auditory and language skills. .


INTRODUÇÃO: A reabilitação auditiva em crianças com deficiência auditiva neurossensorial severa a profunda bilateral com o Implante Coclear foi consagrado nas últimas décadas, contudo, ainda permanece um desafio para a otorrinolaringologia e a fonoaudiologia a reabilitação do portador de paralisia cerebral. OBJETIVO: Verificar a efetividade do Implante Coclear no desenvolvimento das habilidades auditivas e de linguagem em crianças com paralisia cerebral. MÉTODO: Estudo analítico prospectivo. Foram aplicados testes padronizados que avaliam e quantificam o desenvolvimento das habilidades auditivas e de linguagem. Foram analisadas as filmagens das terapias fonoaudiológicas e os registros descritos ao término de cada sessão de terapia. RESULTADOS: As crianças analisadas apresentaram desenvolvimento auditivo e de linguagem satisfatório quando comparado às demais crianças que alcançaram níveis mais complexos nas categorias de audição e evolução significativa no desenvolvimento da linguagem oral. CONCLUSÃO: O uso do Implante Coclear favoreceu o alcance de etapas avançadas das habilidades de audição e linguagem em três das cinco crianças com paralisia cerebral desse estudo. Esse dispositivo eletrônico tem sido uma opção terapêutica viável para que crianças com paralisia cerebral alcancem etapas complexas no que se refere às habilidades auditivas e de linguagem. .


Subject(s)
Humans , Male , Female , Child, Preschool , Cerebral Palsy/complications , Cochlear Implantation , Cochlear Implants , Hearing Loss, Sensorineural/rehabilitation , Language Development , Speech Perception , Hearing Loss, Sensorineural/etiology , Hearing Loss, Sensorineural/surgery , Language Development Disorders/surgery , Language Tests , Prospective Studies , Speech Production Measurement , Treatment Outcome
10.
Article in English | WPRIM | ID: wpr-154363

ABSTRACT

This study compared long-term speech performance after cochlear implantation (CI) between surgical strategies in patients with chronic otitis media (COM). Thirty patients with available open-set sentence scores measured more than 2 yr postoperatively were included: 17 who received one-stage surgeries (One-stage group), and the other 13 underwent two-stage surgeries (Two-stage group). Preoperative inflammatory status, intraoperative procedures, postoperative outcomes were compared. Among 17 patients in One-stage group, 12 underwent CI accompanied with the eradication of inflammation; CI without eradicating inflammation was performed on 3 patients; 2 underwent CIs via the transcanal approach. Thirteen patients in Two-stage group received the complete eradication of inflammation as first-stage surgery, and CI was performed as second-stage surgery after a mean interval of 8.2 months. Additional control of inflammation was performed in 2 patients at second-stage surgery for cavity problem and cholesteatoma, respectively. There were 2 cases of electrode exposure as postoperative complication in the two-stage group; new electrode arrays were inserted and covered by local flaps. The open-set sentence scores of Two-stage group were not significantly higher than those of One-stage group at 1, 2, 3, and 5 yr postoperatively. Postoperative long-term speech performance is equivalent when either of two surgical strategies is used to treat appropriately selected candidates.


Subject(s)
Adult , Aged , Cholesteatoma, Middle Ear/epidemiology , Chronic Disease/therapy , Cochlear Implantation/adverse effects , Cochlear Implants/adverse effects , Female , Hearing Loss, Sensorineural/surgery , Humans , Inflammation/epidemiology , Male , Middle Aged , Otitis Media/surgery , Retrospective Studies , Speech Articulation Tests , Treatment Outcome , Young Adult
11.
Braz. j. otorhinolaryngol. (Impr.) ; 80(4): 305-310, Jul-Aug/2014. graf
Article in English | LILACS | ID: lil-721410

ABSTRACT

INTRODUCTION: Knowledge of the characteristics related to profound hearing loss is a matter of great importance, as it allows for the etiological and prognostic identification and strategic planning for public health interventions. OBJECTIVE: To assess the different etiologies of hearing loss, age at diagnosis of the hearing loss, its relation to language acquisition, and the age at the first consultation in this service for cochlear implant assessment. METHODS: This was a historical cohort, cross-sectional study, using retrospective analysis of the records of 115 patients with confirmed sensorineural hearing loss, who were followed in a university hospital, based on gender, age of hearing loss, age at the first consultation, language, and hearing loss etiology. RESULTS AND CONCLUSION: The majority of patients assessed for cochlear implants attend the first consultation when they are older than one year (an alarming mean of 3.8 years in the prelingual group) in spite of the early diagnosis of hearing loss. This reflects an already deficient health care system, in terms of referral. The idiopathic cause remains the most frequently identified. Among the known causes, the most prevalent are perinatal causes and meningitis. .


INTRODUÇÃO: O conhecimento das características relacionadas à perda auditiva profunda é de extrema importância já que permite a identificação etiológica e de fatores prognósticos e planejamento estratégico para intervenções de saúde pública. OBJETIVO: Verificar as diferentes etiologias da perda auditiva, idade de diagnóstico da perda, relacionada ou não à aquisição de linguagem e idade dos pacientes ao procurar o serviço para a avaliação de implante coclear. MÉTODO: Estudo de casos, de coorte histórica transversal, com análise retrospectiva de arquivos de 115 pacientes com perda auditiva neurossensorial comprovada acompanhados num hospital universitário, com base em sexo, idade da perda, idade na primeira consulta, linguagem e etiologia da perda. RESULTADOS E CONCLUSÃO: os pacientes avaliados para implante coclear chegam à primeira consulta, em sua maioria, com mais de um ano de idade (média preocupante de 3,8 anos no grupo pré-lingual), apesar de o diagnóstico da perda ser precoce, o que reflete um sistema ainda deficiente em termos de referenciamento. A causa idiopática ainda é a mais encontrada. Dentre as etiologias conhecidas, as mais prevalentes são as perinatais e a meningite. .


Subject(s)
Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Male , Young Adult , Cochlear Implantation , Cochlear Implants , Hearing Loss, Sensorineural/surgery , Cross-Sectional Studies , Hearing Loss, Sensorineural/etiology , Retrospective Studies
12.
São Paulo; s.n; 2014. [103] p. ilus, tab.
Thesis in Portuguese | LILACS | ID: lil-719951

ABSTRACT

Introdução: A técnica clássica para o implante coclear é realizada por meio de mastoidectomia seguida de timpanotomia posterior. O acesso pela fossa craniana média provou ser uma alternativa valiosa, embora seja usada para o implante coclear, ainda sem normatização. Objetivo: Descrever um novo acesso pela fossa craniana média que expõe o giro basal da cóclea para o implante coclear. Métodos: Estudo anatômico de ossos temporais. Foram dissecados 50 ossos temporais. A cocleostomia foi realizada mediante um acesso via fossa craniana média, na porção mais superficial do giro basal da cóclea, usando o plano meatal e seio petroso superior como as principais referências anatômicas. Foi determinada a distância entre os pontos de referência, o ângulo entre o plano meatal e a cocleostomia, e a distância entre esta estrutura e a janela redonda. Foi realizada tomografia computadorizada em 5 dos ossos temporais utilizados neste estudo. Resultados: Em todos os 50 ossos temporais, apenas a porção mais superficial do giro basal da cóclea foi aberta e tanto as escalas timpânica como a vestibular foram visualizadas. As distâncias médias ± DP, menores e maiores, entre a cocleostomia e o plano meatal foram estimadas em 2,48±0,88mm e 3,11±0,86mm, respectivamente. A distância média da cocleostomia até a janela redonda foi de 8,38±1,96mm, e daquela até o seio petroso superior 9,19±1,59mm. As distâncias médias, menores e maiores, entre a cocleostomia e o eixo longo do plano meatal a partir da sua porção mais proximal foram estimadas em 6,63±1,38mm e 8,2±1,43mm, respectivamente. O valor médio do ângulo entre a cocleostomia e o plano meatal foi igual a 22,54±7,400. As tomografias computadorizadas demonstraram a inserção do feixe de eletrodos por meio do giro basal da cóclea até o seu ápice em todas as peças submetidas a este exame. Conclusão: A técnica proposta para identificar o giro basal da cóclea é simples e confiável. Igualmente, permite a visualização da escala timpânica e a...


Introduction: The classic technique for cochlear implantation uses mastoidectomy followed by posterior tympanotomy. The middle cranial fossa approach has proved to be a valuable alternative for cochlear implantation, although the standardization of this technique is still needed. Objectives: To describe a novel approach through the middle cranial fossa for exposing the cochlear basal turn for cochlear implantation. Materials And Methods: Anatomical temporal bone study. Fifty temporal bones were dissected. A cochleostomy was performed via a middle fossa approach on the most superficial part of the cochlear basal turn, using the meatal plane and superior petrous sinus as the main landmarks. The distance between the landmarks, the angle between the cochleostomy and the meatal plane, and the distance between this structure and the round window were measured. A computed tomography was performed on 5 of the studied temporal bones. Results: In all 50 temporal bones, only the superficial portion of the cochlear basal turn was uncovered. The cochlear exposure allowed both the scala tympani and vestibule to be exposed. The mean ± SD minor and major distances between the cochleostomy and the meatal plane were estimated to be 2.48±0.88mm and 3.11±0.86mm, respectively. The mean distance from the cochleostomy to the round window was 8.38±1.96mm, and that to the superior petrosal sinus was 9.19±1.59mm. The mean minor and major distances between the cochleostomy and the long axis of the meatal plane from its most proximal portion were estimated to be 6.63±1.38mm and 8.29±1.43mm, respectively. The mean angle between the cochleostomy and the meatal plane was 22.54±7.400. The computed tomography of all 5 temporal bones demonstrated the insertion of the implant array from the cochlear basal turn towards its apex. Conclusion: The proposed technique for identifying the cochlear basal turn is simple and trustworthy. Additionally, it enables visualization of the scala tympani...


Subject(s)
Humans , Male , Female , Adult , Cadaver , Cochlear Implantation , Cranial Fossa, Middle/anatomy & histology , Cranial Fossa, Middle/surgery , Cochlear Implantation/methods , Neuroanatomy , Temporal Bone/anatomy & histology , Temporal Bone/surgery , Hearing Loss, Sensorineural/surgery , Hearing Loss, Sensorineural/rehabilitation , Tomography, X-Ray Computed
13.
Rev. otorrinolaringol. cir. cabeza cuello ; 73(3): 219-224, dic. 2013. graf, tab
Article in Spanish | LILACS | ID: lil-704549

ABSTRACT

Introducción: La hipoacusia sensorioneural infantil es una causa frecuente de discapacidad en la infancia. Si bien la intervención ha demostrado ser costo efectiva, un alto porcentaje no accede al implante coclear por problemas de cobertura de los servicios de salud. Objetivo: Conocer el uso y distribución del gasto público de salud en el programa piloto de implantes cocleares del Hospital Barros Luco Trudeau. Material y método: Se realizó un Análisis de Beneficio de Incidencia, que permite conocer la distribución y el uso del gasto público en salud entre los distintos grupos socioeconómicos. Resultados: Durante el período del estudio se realizaron 73 implantes cocleares en menores de 15 años, correspondiendo a 35 niñas y 38 hombres. El 56,1% de los menores con implante coclear se ubicaban en el primer quintil de ingresos, el 27,5% al segundo quintil, 15,1% en el tercer quintil, y un caso pertenecía al cuarto quintil, no registrándose ningún niño en el quinto quintil de ingresos según los datos de la encuesta CASEN 2009. Discusión: Al evaluar el programa se deduce que en este caso específico los recursos públicos se encuentran focalizados hacia la población con menores ingresos económicos y con menor acceso a los servicios sanitarios.


Introduction: Childhood sensorineural hearing loss is a common cause of disability in children, with harmful consequences for individuals, family and society if it is not detected and treated early in life. While the intervention has proven to be cost effective, a high percentage does not access the cochlear implant coverage because of problems of health care. Aim: To determine the use and distribution of public expenditure in health in the pilot program of cochlear implants of the Barros Luco Trudeau Hospital. Material and method: We conducted a Benefit/Incidence Analysis, that is a model that evaluate the distribution and use of public expenditure on health between different socioeconomic groups. Results: During the study period there were performed 73 cochlear implants in children under 15years, corresponding to 35 girls and 38 men. The 56.1% of children with cochlear implants belonged to the lowest income quintile, 27.5% to the second quintile, 15.1% belonged to the third quintile, and one case belonged to the fourth quintile. There were no child of the fifth quintile of income according to the data of the 2009 CASEN survey. Discussion: When evaluating the program, in this specific case we can establish that public resources are targeted to people with lower incomes and less access to health services.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Health Care Costs , Cochlear Implantation/economics , Hearing Loss, Sensorineural/surgery , Socioeconomic Factors , Chile , Pilot Projects , Cochlear Implantation/statistics & numerical data , Hearing Loss, Sensorineural/economics
14.
Rev. otorrinolaringol. cir. cabeza cuello ; 73(3): 231-237, dic. 2013. graf, tab
Article in Spanish | LILACS | ID: lil-704551

ABSTRACT

Introducción: La hipoacusia sensorioneural bilateral profunda es la tercera causa de discapacidad en Chile, con una incidencia de entre 1 a 3 casos por cada 1.000 nacidos vivos, siendo muchos casos susceptibles de ser tratados mediante implante coclear. Objetivo: Describir resultados de la cohorte de pacientes implantados en el Hospital Barros Luco Trudeau. Material y método: Estudio de cohorte retrospectiva. Se reportan los resultados de la totalidad de pacientes implantados en el período 2003-2011. Resultados: Fueron implantados 80pacientes. La mediana de edad de implantación fue 48 meses. Treinta y siete (46,25%) pacientes fueron mujeres, 7 (8,75%) fueron prematuros, y 14 (17,5%) tenían el antecedente de meningitis bacteriana. Sesenta y ocho (85%) fueron diagnósticos prelinguales, 9 (11,25%) poslinguales, y 3 (3,75%) perilinguales. El PTP promedio prequirúrgico fue 111,82 dB, y el posquirúrgico con implante 25,36 dB (p <0,0001). Respecto a integración, el 100% de los pacientes poslinguales, el 67,7% de los prelinguales, y el 100% de los perilinguales se encuentran integrados a sus actividades. Se ha observado el 5% de complicaciones: una parálisis facial, un hematoma infectado y dos alergias a cera de hueso. Conclusión: Los resultados de este programa son altamente satisfactorios. Todos los pacientes se encuentran en seguimiento hasta la fecha con una buena adherencia terapéutica y rehabilitación. La evaluación de este programa permite plantear que debería ampliarse.


Introduction: Profound bilateral sensorioneural hearing loss is the third leading cause of disability in Chile, with an incidence of 1 to 3 cases for every 1.000 born, which may be managed with cochlear implants. Aim: Describe results of the cohort of patients implanted at Barros Luco Trudeau Hospital. Material and method: Retrospective cohort study. We report the results of all patients implanted in the period from 2003 to 2011. Results: 80 patients were implanted. The median age at implantation was 48 months. 37 (46.25%) patients were female, 7 (8.75%) were premature, and 14 (17.5%) had a history of bacterial meningitis. 68 (85%) were prelingual diagnosed, 9 (11.25%) post-lingual, and 3 (3.75%) perilinguals. The average preoperative PTP was 111.82 dB, and postoperative was 25.36 dB (p <0.0001). Regarding integration, 100% of postlingual patients, 67.7% of prelingual, and 100% of perilinguales are fully integrated into their activities. There have been 5% complications: one facial paralysis, one infected hematoma, and two bone wax allergies. Conclusion: The results of this program are highly satisfactory. All patients are up to date with good adherence and rehabilitation. The evaluation of this program allows us to suggest that should be expanded.


Subject(s)
Humans , Male , Female , Child, Preschool , Adult , Cochlear Implantation/statistics & numerical data , Hearing Loss, Sensorineural/surgery , Program Evaluation , Chile , Retrospective Studies , Cohort Studies , Treatment Outcome
15.
CoDAS ; 25(6): 521-526, 25/1jan. 2013. tab, graf
Article in English | LILACS | ID: lil-699835

ABSTRACT

Purpose: To assess the characteristics of P1 component in children presented with pre-lingual hearing loss, users of cochlear implants, and correlate them with speech perception performance. Methods: Ten children presented with pre-lingual sensory neural hearing loss using cochlear implants participated in this research. The cortical auditory evoked potential research was carried out with the /da/ speech stimulus, presented in free field, in three moments: at cochlear implant activation, with three and six months following activation. The Infant-Toddler Meaningful Auditory Integration Scale was used to verify the speech perception. Results: The correlation of the three moments of the test with the latency and the amplitude of P1 component through analysis of variance were observed. The comparison of latency and amplitude of P1 in each assessment moment was performed with Tukey's test. Wilcoxon and t-test showed that the score on the Infant-Toddler Meaningful Auditory Integration Scale increased significantly with the time of cochlear implant use, nevertheless with no correlation with the latency and amplitude of P1 component in the moments assessed, as demonstrated by Spearman's and Pearson's correlations. Conclusion: The latency and amplitude of P1 component diminish as the time of cochlear implant use increases. However, there was no correlation between its development and speech perception performance. .


OBJETIVO: Analisar as características do componente P1 em crianças com perda auditiva pré-lingual usuárias de implante coclear e correlacioná-las com o desempenho na percepção auditiva da fala. MÉTODOS: Participaram desta pesquisa dez crianças com perda auditiva pré-lingual e usuárias de implante coclear. A pesquisa do potencial evocado auditivo cortical foi realizada com o estímulo de fala /da/, apresentado em campo livre, em três momentos: na ativação do implante coclear, com três e seis meses após a ativação. Para verificar a percepção auditiva da fala, foi utilizada a Escala de Integração Auditiva Significativa para Crianças Pequenas. RESULTADOS: Foi observada correlação dos três momentos de avaliação com a latência e amplitude do componente P1 por meio da análise de variância. A comparação da latência e amplitude de P1 em cada momento foi realizada com o teste de Tukey. O teste de Wilcoxon e o teste t demonstraram que a pontuação na Escala de Integração Auditiva Significativa para Crianças Pequenas aumentou de forma significativa com o tempo de uso do implante coclear, porém sem correlação com a latência e amplitude do componente P1 nos momentos avaliados, conforme demonstrado pelas correlações de Spearman e Pearson. CONCLUSÃO: A latência e amplitude do componente P1 diminuem com o aumento do tempo de uso do implante coclear. No entanto, não houve correlação de seu desenvolvimento com o desempenho na percepção da fala. .


Subject(s)
Child, Preschool , Humans , Infant , Cochlear Implantation , Evoked Potentials, Auditory/physiology , Hearing Loss, Sensorineural/rehabilitation , Speech Perception/physiology , Cochlear Implants , Hearing Loss, Sensorineural/surgery , Longitudinal Studies
16.
Braz. j. otorhinolaryngol. (Impr.) ; 79(3): 298-305, maio-jun. 2013. ilus, tab
Article in Portuguese | LILACS | ID: lil-675683

ABSTRACT

O implante coclear é um grande avanço no tratamento da surdez. Há grandes evidências que a audição bilateral traz diversas vantagens ao ser humano e muito mais quando se trata de audição binaural. OBJETIVO: Este artigo tem por objetivo descrever o primeiro caso operado no Brasil, sendo o terceiro país das Américas (México e Colômbia) a realizar, com implante binaural Neurelec Digisonic SP® demonstrando a técnica cirúrgica. MÉTODO: Descrição da técnica cirúrgica. RESULTADOS: Ver técnica cirúrgica. Procedimento ocorreu sem intercorrências. DISCUSSÃO: O efeito "squelch", a somação binaural, a localização da fonte sonora e o efeito sombra da cabeça são umas das principais razões que justificam a superioridade da reabilitação binaural. O custo do tratamento deve ser levado em conta em políticas de saúde pública. CONCLUSÃO: Custo do implante coclear é um dos grandes limitadores da bilateralidade na reabilitação desse grupo de pacientes, porém, com essa tecnologia, é possível solucionar esse problema, expondo o paciente a poucos riscos, com o uso de uma técnica cirúrgica pouco invasiva.


Cochlear implants represent a significant breakthrough in the treatment of hearing loss. Evidence indicates bilateral hearing brings significant benefits to patients, particularly when binaural hearing is offered. OBJECTIVE: To describe the first case of implantation of a Digisonic SP® Binaural Neurelec device in Brazil (the third implant placed in the Americas, after Mexico and Colombia) and the chosen surgical approach. METHOD: Description of a surgical approach. RESULTS: The procedure was successfully completed. DISCUSSION: The squelch effect, binaural summation, location of the sound source, and the shadow effect of the head are listed among the reasons to explain the superiority of binaural rehabilitation. Cost of treatment must be considered in the development of public health policies. CONCLUSION: The cost of cochlear implants has been one of the main impediments to bilateral rehabilitation. The Digisonic SP® Binaural Neurelec device addresses this issue and exposes patients to less risk through a minimally invasive implantation procedure.


Subject(s)
Adult , Female , Humans , Male , Cochlear Implants , Cochlear Implantation/methods , Hearing Loss, Bilateral/surgery , Hearing Loss, Sensorineural/surgery , Cochlear Implantation/instrumentation , Sound Localization , Speech Perception , Treatment Outcome
18.
Rev. panam. salud pública ; 31(4): 325-331, apr. 2012. tab
Article in Spanish | LILACS | ID: lil-620079

ABSTRACT

Objective. Evaluate the cost-benefit, cost-utility, and cost-effectiveness of cochlear implantation, comparing it to the use of hearing aids in children with profound bilateral sensorineural hearing loss. Methods. The nonparametric propensity score matching method was used to carry out an economic and impact assessment of the cochlear implant and then perform cost-benefit, cost-utility, and cost-effectiveness analyses. Primary information was used, taken randomly from 100 patients: 62 who received cochlear implants (treatment group) and 38 belonging to the control group who used hearing aids to treat profound sensorineural hearing loss. Results. An economic cost differential was found—to the advantage of the cochlear implant—of close to US$ 204 000 between the implant and the use of hearing aids over the expected life span of the patients analyzed. This amount refers to the greater expenses that hearing-aid patients will have. With this adjusted figure, the cost-benefitindicator shows that for each dollar invested to treat the cochlear-implant patient, there is a return on the investment of US$ 2.07. Conclusions. The cochlear implant produces economic benefits for the patient. It also produces health utilities since positive cost-utility (gain in decibels) and costeffectiveness(gain in language discrimination) ratios were found.


Objetivo. Evaluar el costo-beneficio (CB), costo-utilidad (CU) y costo-efectividad (CE) de la implantación coclear, comparándola con el uso de audífonos en niños con hipoacusia sensorineural profunda bilateral.Métodos. Se empleó la técnica no paramétrica Propensity Score Matching (PSM) para realizar la evaluación de impacto económico del implante y así llevar a cabo los análisis CB, CU yCE. Se utilizó información primaria, tomada aleatoriamente a 100 pacientes: 62 intervenidos quirúrgicamente con el implante coclear (grupo de tratamiento) y 38 pertenecientes al grupo de control o usuarios de audífono para tratar la hipoacusia sensorineural profunda.Resultados. Se halló un diferencial de costos económicos —en beneficio del implante coclear— cercano a US$ 204 000 entre el implante y el uso de audífonos durante la esperanza de vida de los pacientes analizados. Dicha cifra indica los mayores gastos que deben cubrir los pacientes con audífono. Con este valor descontado, el indicador costo-beneficio señala que por cada dólar invertido en el implante coclear, para tratar al paciente, el retorno de la inversión es US$ 2,07. Conclusiones. El implante coclear genera beneficios económicos para el paciente. Tambiénproduce utilidades en salud dado que se encontró una relación positiva de CU (ganancia en decibeles) y CE (ganancia en discriminación del lenguaje).


Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Cochlear Implants/economics , Hearing Loss, Sensorineural/economics , Hearing Loss, Sensorineural/surgery , Cost-Benefit Analysis
19.
Braz. j. otorhinolaryngol. (Impr.) ; 78(2): 124-127, mar.-abr. 2012. tab
Article in Portuguese | LILACS | ID: lil-622853

ABSTRACT

Devido aos avanços na tecnologia dos implantes cocleares e das estratégias de processamento, indivíduos com surdez grave a profunda puderam ouvir sons e reconhecer fala em diferentes graus. A variabilidade nos resultados audiológicos em portadores de surdez pós-lingual tem sido grande e a indicação para o implante coclear tem se estendido e inclui uma população cada vez maior. OBJETIVO: Avaliar em quais pacientes portadores de surdez pós-lingual o implante coclear traz benefício auditivo superior ao da prótese auditiva convencional. MATERIAIS E MÉTODOS: consulta a artigos científicos por busca no banco de dados SciELO, Cochrane, MEDLINE e LILACS-BIREME. Foram selecionadas publicações com força de evidência A ou B até a data da investigação, que comparassem aparelhos de amplificação sonora e implante coclear na população com surdez pós-lingual. Desenho do Estudo: revisão sistemática. RESULTADOS: Entre os 2169 artigos consultados, 11 trabalhos se mostram pertinentes ao tema e apresentaram força de evidência B. Seis estudos são do tipo coorte prospectivo, quatro são estudos transversais e um ensaio clinico. CONCLUSÃO: A avaliação dos benefícios obtidos por portadores de surdez pós-lingual reabilitados com o uso de implante coclear mostra que este dispositivo é efetivo e apresenta melhores resultados quando comparado aos aparelhos de amplificação sonora individual.


The technological advances in cochlear implants and processing strategies have enabled subjects affected by severe to profound hearing loss to hear sounds and recognize speech in various different degrees. The variability of hearing outcomes in subjects with post-lingual deafness has been significant and cochlear implant indications have been extended to include an ever larger population. OBJECTIVE: This paper aims to look into the groups of post-lingual deafness patients to find where cochlear implants have yielded better outcomes than conventional hearing aids. MATERIALS AND METHODS: Review the literature available on databases SciELO, Cochrane, MEDLINE, and LILACS-BIREME. The publications selected for review were rated as A or B on evidence strength on the day of the review. Their authors analyzed and compared hearing aids and cochlear implants in populations of post-lingually deaf patients. Study Design: Systematic review. RESULTS: Eleven out of the 2,169 papers searched were found to be pertinent to the topic and were rated B for evidence strength. Six studies were prospective cohort trials, four were cross-sectional studies and one was a clinical trial. CONCLUSION: The assessment done on the benefits yielded by post-lingually deaf subjects from cochlear implants showed that they are effective and provide for better results than conventional hearing aids.


Subject(s)
Humans , Cochlear Implantation/methods , Deafness/rehabilitation , Hearing Aids , Hearing Loss, Sensorineural/rehabilitation , Deafness/surgery , Hearing Loss, Sensorineural/surgery , Speech Perception
20.
Braz. j. otorhinolaryngol. (Impr.) ; 78(1): 43-50, jan.-fev. 2012. ilus, tab
Article in Portuguese | LILACS | ID: lil-616935

ABSTRACT

A reabilitação auditiva entrou numa nova era com o desenvolvimento e aperfeiçoamento de próteses implantáveis, principalmente com a associação do conceito de a estimulação eletroacústica (EAS) e implante coclear. A EAS é indicada para pacientes com audição residual nas baixas frequências e disacusia grave/profunda nas médias e altas frequências. Esses pacientes não teriam indicação para o implante coclear convencional e teriam dificuldades na adaptação com o aparelho de amplificação sonoro individual. A técnica cirúrgica utilizada deve-se basear nos conceitos de preservação auditiva e é fundamental nesse processo. OBJETIVOS: Descrever a técnica cirúrgica para procedimento de implante coclear MED-EL Mand FlexEAS, com intuito de preservar o resíduo auditivo e reabilitar satisfatoriamente a audição deteriorada, sendo o primeiro centro a realizar tal tratamento no Brasil. MATERIAL E MÉTODOS: Descrição de técnica cirúrgica utilizada pelo serviço de otologia de hospital terciário por meio de estudo de caso. RESULTADOS: Procedimentos realizados sem intercorrências. A técnica utilizada segue passos que objetivam a preservação auditiva. CONCLUSÃO: Descrevemos a técnica utilizada para implantes com EAS realizados no nosso serviço. A técnica cirúrgica é complexa e inclui passos que visam à preservação auditiva.


A new era has arrived in auditory rehabilitation with the introduction of new technologies such as electroacoustic stimulation (EAS). EAS is indicated for patients with residual hearing at low frequencies and severe or profound hearing loss at high frequencies. These patients have no indication for conventional cochlear implant and have difficulties in adapting to individual sound amplification devices. Preservation of hearing is vital in this process; the surgical technique must be based on this concept. OBJECTIVES: To present the cochlear implant surgical technique with MED-EL Mand FlexEAS to preserve hearing in patients with hearing loss at high frequencies and to maintain low frequency hearing. We are the first institution to carry out this treatment in Brazil. METHODS: A case report of the surgical technique carried out in four patients; the procedure was carried out by the cochlear implant group of a specialized clinical hospital. RESULTS: The procedures were successful and uneventful. CONCLUSION: We described the technique used at our institution for implants using EAS; the surgical technique is complex and includes steps for preservation of hearing.


Subject(s)
Humans , Acoustic Stimulation/methods , Cochlear Implantation/methods , Electric Stimulation/methods , Hearing Loss, Bilateral/surgery , Hearing Loss, Sensorineural/surgery , Hearing Loss, Bilateral/rehabilitation , Hearing Loss, Sensorineural/rehabilitation , Severity of Illness Index , Treatment Outcome
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