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Rev. urug. cardiol ; 36(1): e36108, abr. 2021. ilus
Article in Spanish | BNUY, UY-BNMED, LILACS | ID: biblio-1252493


Los linfomas cardíacos primarios son un subtipo muy poco frecuente de tumor en los cuales la lesión primaria se encuentra en el corazón. Los tumores suelen ser infiltrantes y se localizan en la aurícula derecha, seguidos del pericardio. Su mortalidad es notablemente alta y el diagnóstico tardío es el principal factor para su mal pronóstico. Describimos el caso de un paciente que presentó shock obstructivo por derrame pericárdico profuso causado por un tipo raro de tumor cardíaco primario, un linfoma pericárdico de células T/NK.

Primary cardiac lymphomas are a rare subtype of lymphomas in which the primary lesion is in the heart. The tumors are usually located in the right atria, followed by the pericardium and are frequently infiltrative. Mortality is remarkably high in this group and the delayed diagnosis is the main factor for its poor prognosis. We describe the case of a patient that presented with obstructive shock due to profuse pericardial effuse caused by a rare kind of primary cardiac tumor, a T/NK cell pericardial lymphoma.

Os linfomas cardíacos primários são um subtipo de tumor muito raro, no qual a lesão primária está no coração. Os tumores geralmente são infiltrativos e localizam-se no átrio direito, seguidos pelo pericárdio. Sua mortalidade é notavelmente alta e o diagnóstico tardio é o principal fator que produz seu mau prognóstico. Descrevemos o caso de um paciente que apresentou choque obstrutivo devido a um derrame pericárdico profuso causado por um tipo raro de tumor cardíaco primário, um linfoma pericárdico de células T/NK.

Humans , Female , Aged , Lymphoma, T-Cell/pathology , Lymphoma, T-Cell/drug therapy , Lymphoma, T-Cell/diagnostic imaging , Heart Neoplasms/pathology , Heart Neoplasms/drug therapy , Heart Neoplasms/diagnostic imaging , Pericardial Effusion/therapy , Pericardial Effusion/diagnostic imaging , Pericardium/pathology , Cardiac Tamponade/therapy
Rev. bras. cir. cardiovasc ; 34(4): 499-502, July-Aug. 2019. tab, graf
Article in English | LILACS | ID: biblio-1020485


Abstract Cardiac papillary fibroelastoma are rare, benign cardiac tumors that may lead to lethal complications from embolization or valvular dysfunction if left untreated. When working up symptomatic tumors with concomitant angina, traditional diagnostic studies such as cardiac catheterization may predispose the patient to embolic complications if the mass is located in the path of the catheter. Newer, non-invasive diagnostic testing, such as cardiac magnetic resonance imaging or dynamic computed tomography angiography, may be considered in lieu of invasive approaches to avoid potentially devastating complications. We herein present a case report of a 77-year-old female with a symptomatic aortic valve tumor and describe our diagnostic strategy and management.

Humans , Female , Aged , Aortic Valve/diagnostic imaging , Heart Neoplasms/diagnostic imaging , Computed Tomography Angiography/methods , Heart Neoplasms/surgery , Heart Neoplasms/pathology , Heart Valve Diseases/surgery , Heart Valve Diseases/diagnostic imaging
Rev. bras. cir. cardiovasc ; 34(3): 372-376, Jun. 2019. tab, graf
Article in English | LILACS | ID: biblio-1013471


Abstract We are going to present a case of malignant fibrous histiocytoma in the right atrium, which is a very rare entity. The patient had a right atrial mass, which prolapsed through the tricuspid valve into the right ventricle, causing functional tricuspid valve stenosis. The tumor was completely resected and the patient had an uneventful postoperative period. Histopathological examination reported malignant fibrous histiocytoma. The patient presented to the emergency department five weeks after discharge with dyspnea and palpitation. Echocardiography and magnetic resonance imaging revealed recurrent right atrial tumor mass. His clinical status has worsened, with syncope and acute renal failure. On the repeated echocardiography, suspected tumor recurrence was observed in left atrium, which probably caused systemic embolization. Considering the aggressive nature of the tumor and systemic involvement, our Heart Council decided to provide palliative treatment by nonsurgical management. His status deteriorated for the next few days and the patient succumbed to a cardiac arrest on the 4th day.

Humans , Male , Histiocytoma, Malignant Fibrous/pathology , Heart Neoplasms/pathology , Magnetic Resonance Imaging , Echocardiography , Tomography, X-Ray Computed , Tricuspid Valve Prolapse/pathology , Tricuspid Valve Prolapse/diagnostic imaging , Coronary Angiography , Fatal Outcome , Rare Diseases , Histiocytoma, Malignant Fibrous/diagnostic imaging , Heart Atria/pathology , Heart Atria/diagnostic imaging , Heart Neoplasms/diagnostic imaging , Neoplasm Recurrence, Local
Rev. bras. cir. cardiovasc ; 34(1): 22-27, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-985231


Abstract Objective: To disclose the relationships between the anatomic features of cardiac myxomas and plasma interleukin (IL)-6 levels. Methods: Twelve patients undergoing cardiac myxoma resection at The First Hospital of Putian, Teaching Hospital, Fujian Medical University were enrolled into this study. Pre- and postoperative IL-6 levels were determined by an enzyme-linked immunosorbent assay method, and correlations between cardiac myxoma dimension or volume and plasma IL-6 levels were analyzed. C-reactive protein (CRP) levels were also evaluated. Results: IL-6 and CRP levels were significantly decreased one month after cardiac myxoma resection in comparison to preoperative values. IL-6 and CRP levels did not differ between patients with a cardiac myxoma of irregular appearance and those with a myxoma of regular gross appearance, or between patients with a pedicled or a sessile myxoma. Decrement of IL-6 of patients with irregular cardiac myxomas was much higher than that of patients with regular ones, while no intergroup difference was noted in decrement of CRP. A close direct correlation was noted between IL-6 levels and maximal dimension (length) or volume of cardiac myxomas, whereas CRP levels only correlated with maximal dimension of cardiac myxomas. Conclusion: Anatomic features of cardiac myxomas (sessile, irregular appearance, maximal dimension, and volume) could be determinants of the patients' circulating IL-6 levels. IL-6 was likely to be a more sensitive biomarker than CRP in predicting the inflammatory status of patients with cardiac myxoma. Sessile and irregular cardiac myxomas might predict more severe inflammatory conditions for their more abundant endothelial cells and IL-6 overproduction.

Humans , Male , Female , Middle Aged , Aged , C-Reactive Protein/analysis , Interleukin-6/blood , Heart Neoplasms/blood , Myxoma/blood , Postoperative Period , Reference Values , Enzyme-Linked Immunosorbent Assay , Biomarkers, Tumor/blood , Retrospective Studies , Tumor Burden , Preoperative Period , Heart Neoplasms/surgery , Heart Neoplasms/pathology , Myxoma/surgery , Myxoma/pathology
Rev. méd. Chile ; 147(2): 243-246, Feb. 2019. graf
Article in Spanish | LILACS | ID: biblio-1004338


Embolic stroke secondary to cardiac tumors is uncommon. However, 25-30% of cardiac tumors may cause systemic emboli. We report a 29-year-old male consulting for a sudden episode of aphasia and right hemiparesis, compatible with infarct of the left middle cerebral artery territory. Transthoracic echocardiography reported an ovoid tumor of 8 × 7 × 7 mm in relation to the sub valvular apparatus of the mitral valve. After neurologic stabilization, surgical treatment was performed. Approached by median sternotomy and in cardiopulmonary bypass, the mitral valve was explored. A macroscopic tumor consistent with a papillary fibroelastoma curled in sub valvular chordae was found. It was deployed and resected from its base, while the anterior mitral leaflet was preserved intact. Histopathological examination confirmed the intraoperative macroscopic diagnosis. The patient recovered uneventfully postoperatively and was discharged on the fifth day after surgery. He currently is in functional capacity I without cardiovascular symptoms at five years follow-up.

Humans , Male , Adult , Infarction, Middle Cerebral Artery/etiology , Fibroma/complications , Heart Neoplasms/complications , Heart Valve Diseases/complications , Papillary Muscles , Echocardiography , Sternotomy , Fibroma/surgery , Fibroma/pathology , Fibroma/diagnostic imaging , Heart Neoplasms/surgery , Heart Neoplasms/pathology , Heart Neoplasms/diagnostic imaging , Heart Valve Diseases/surgery , Heart Valve Diseases/diagnostic imaging , Mitral Valve
Rev. bras. cir. cardiovasc ; 33(5): 525-527, Sept.-Oct. 2018. tab, graf
Article in English | LILACS | ID: biblio-977460


Abstract Primary angiosarcoma is a rare clinical entity, it's typically located within the right atrium and known to be rapidly fatal. A 37-year-old female was presented with a history of recurrent facial paralysis and left hemiparesis. A cranial mass was identified at cranial magnetic resonance imaging and she underwent neurosurgery operation. The immunohistochemical examination was determined as metastatic cardiac angiosarcoma. The tumor, as well as part of the right pericardium, were resected. A piece of bovine pericardium was used to reconstruct the right atrial wall. Tricuspid valve was reconstructed with ring annuloplasty. Due to resection of right coronary artery with the tumor, coronary bypass surgery was performed successfully. The patient is currently healthful without any recurrence and complaint 12 months after the diagnosis as followed up.

Humans , Female , Middle Aged , Brain Neoplasms/secondary , Heart Neoplasms/pathology , Heart Neoplasms/diagnostic imaging , Brain Neoplasms/surgery , Brain Neoplasms/diagnostic imaging , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Treatment Outcome , Echocardiography, Transesophageal , Hemangiosarcoma/surgery , Hemangiosarcoma/pathology , Hemangiosarcoma/diagnostic imaging
Rev. bras. cir. cardiovasc ; 33(3): 306-308, May-June 2018. tab, graf
Article in English | LILACS | ID: biblio-958418


Abstract Giant cell myocarditis is a rare and highly lethal disorder with resultant cardiac insufficiency. It necessitates aggressive immune suppression therapy, although the results are often fatal. When it affects only the atria, the characteristics of the disease changes completely. In this case report, we present atypical presentation of atrial giant cell myocarditis with mass lesion, which completely resolved after successful surgical resection without immuno suppression therapy.

Humans , Male , Middle Aged , Giant Cells/pathology , Heart Neoplasms/pathology , Myocarditis/surgery , Myocarditis/pathology , Immunohistochemistry , Treatment Outcome , Diagnosis, Differential , Heart Atria/pathology , Heart Neoplasms/diagnosis , Myocarditis/diagnosis
São Paulo med. j ; 136(3): 262-265, May-June 2018. tab, graf
Article in English | LILACS | ID: biblio-962720


ABSTRACT CONTEXT: Obstruction of the right ventricular outflow tract due to metastatic disease is rare. Clinical recognition of cardiac metastatic tumors is rare and continues to present a diagnostic and therapeutic challenge. CASE REPORT: We present the case of a patient who had severe respiratory insufficiency and whose clinical examinations revealed a giant tumor mass extending from the right ventricle to the pulmonary artery. We discuss the diagnostic and therapeutic options. CONCLUSION: In patients presenting with acute right heart failure, right ventricular masses should be kept in mind. Transthoracic echocardiography appears to be the most easily available, noninvasive, cost-effective and useful technique in making the differential diagnosis.

RESUMO CONTEXTO: A obstrução da via de saída do ventrículo direito devido a doença metastática é rara. O reconhecimento clínico de tumores cardíacos metastáticos é raro e continua a apresentar um desafio diagnóstico e terapêutico. RELATO DO CASO: Apresentamos o caso de um paciente com insuficiência respiratória grave e cujos exames clínicos revelaram massa de tumor gigante, estendendo-se desde o ventrículo direito até a artéria pulmonar. Discutimos as opções diagnósticas e terapêuticas. CONCLUSÃO: Em pacientes com insuficiência cardíaca direita aguda, massas do ventrículo direito devem ser mantidas em mente. Ecocardiografia transtorácica parece ser a técnica mais facilmente disponível, não invasiva, custo-efetiva e útil no diagnóstico diferencial.

Humans , Male , Aged , Pulmonary Artery/pathology , Adenocarcinoma/secondary , Heart Failure/etiology , Heart Neoplasms/secondary , Pulmonary Artery/diagnostic imaging , Echocardiography , Adenocarcinoma/pathology , Adenocarcinoma/diagnostic imaging , Fatal Outcome , Heart Neoplasms/pathology , Heart Neoplasms/diagnostic imaging , Heart Ventricles
Rev. bras. cir. cardiovasc ; 33(2): 162-168, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-958391


Abstract Objective: Primary cardiac tumors are rare lesions with different histological type. We reviewed our 17 years of experience in the surgical treatment and clinical results of primary non-myxoma cardiac tumors. Methods: Between July 2000 and February 2017, 21 patients with primary cardiac tumor were surgically treated in our institution. The tumors were categorized as benign non-myxomas and malignants. Data including the demographic characteristics, details of the tumor histology and grading, cardiac medical and surgical history, surgical procedure of the patients were obtained from the hospital database. Results: Eleven patients were diagnosed with benign non-myxoma tumor (male/female:7/4), ranging in age from 10 days to 74 years (mean age 30.9±26.5 years). Papillary fibroelastoma was the most frequent type (63.6%). There were two early deaths in benign group (all were rhabdomyoma), and mortality rate was 18%. The mean follow-up period was 69.3±58.7 months (range, 3 to 178 months). All survivals in benign group were free of tumor-related symptoms and tumor relapses. Ten patients were diagnosed with malignant tumor (sarcoma/lymphoma:8/2, male/female:3/7), ranging in age from 14 years to 73 years (mean age 44.7±18.9 years). Total resection could be done in only three (30%) patients. The mean follow-up period was 18.7±24.8 months (range, 0-78 months). Six patients died in the first 10 months. Conclusion: Complete resection of the cardiac tumors, whenever possible, is the main goal of surgery. Surgical resection of benign cardiac tumors is safe, usually curative and provides excellent long-term prognosis. On the contrary, malignant cardiac tumors still remain highly lethal.

Humans , Male , Female , Infant, Newborn , Child, Preschool , Child , Adult , Middle Aged , Aged , Heart Neoplasms/surgery , Heart Neoplasms/pathology , Rhabdomyoma/surgery , Rhabdomyoma/mortality , Rhabdomyoma/pathology , Sarcoma/surgery , Sarcoma/mortality , Sarcoma/pathology , Time Factors , Retrospective Studies , Treatment Outcome , Tumor Burden , Kaplan-Meier Estimate , Fibroma/surgery , Fibroma/mortality , Fibroma/pathology , Heart Neoplasms/mortality , Angiomatosis/surgery , Angiomatosis/mortality , Angiomatosis/pathology , Lymphoma/surgery , Lymphoma/mortality , Lymphoma/pathology
Medicina (B.Aires) ; 77(6): 481-485, dic. 2017. ilus, tab
Article in Spanish | LILACS | ID: biblio-894525


Los fibroelastomas papilares cardíacos son pequeños tumores benignos con potencial embolígeno. Con la incorporación de la ecocardiografía y la mejoría en la resolución de las imágenes, el diagnóstico clínico es cada vez más frecuente, y en series recientes su frecuencia supera a la del mixoma cardíaco. Nuestro objetivo fue analizar las características de una serie de casos de fibroelastoma papilar cardíaco con confirmación histológica operados en nuestro hospital. Analizamos retrospectivamente los tumores cardíacos y las características clínicas de los pacientes operados desde junio de 1992 a febrero de 2017. De 108 operados, 18 presentaron fibroelastoma papilar. La edad media del grupo con fibroelastoma papilar fue 58 años (22-77); 10 eran varones. Las localizaciones más frecuentes fueron la válvula aórtica (7) y la válvula mitral (5). Ninguno presentó disfunción valvular significativa. Por ecografía transesofágica, el tamaño (diámetro mayor) fue 13.33 ± 5.55 mm (6.6-28.0). Cuatro pacientes eran sintomáticos; uno presentaba disnea, otro aleteo auricular, dos con fibroelastoma en válvula aórtica habían sufrido un accidente cerebrovascular. Los restantes, asintomáticos, fueron intervenidos preventivamente. En 15 pacientes el tumor se extirpó sin necesidad de reemplazo valvular. No hubo mortalidad quirúrgica ni recidiva tumoral en el seguimiento de 2.6 años. Se concluye que los fibroelastomas papilares cardíacos pueden ser extirpados con buenos resultados a mediano plazo y, en su mayoría, con preservación valvular. Sin embargo, no existen aún estudios aleatorizados que avalen la escisión quirúrgica en pacientes asintomáticos. Por el momento, esta última depende de la experiencia del grupo quirúrgico tratante.

Papillary ibroelastomas are small benign intracardiac tumors known for their embolic potential. Since the introduction of echocardiography with improved resolution and transesophageal imaging techniques, they are being increasingly detected in clinical practice. In recent series, papillary fibroelastoma is considered the most frequent benign tumor of the heart. Our objective was to analyze characteristics and midterm surgical outcome of histologically-confirmed cases of papillary fibroelastoma. We conducted a retrospective study on patients with cardiac tumors submitted to surgical excision between June 1992 and February 2017. Out of 108 patients, 18 had papillary fibroelastomas. Their mean age was 58 years (22-77); 10 were men. The most frequent localizations were the aortic valve (7) and the mitral valve (5). None had significant valvular dysfunction. By transesophageal echocardiography, the tumor size (larger diameter) was 13.33 ± 5.55 mm (6.6-28.0). Two patients, both with tumor in the aortic valve, had suffered a stroke; other two had dyspnoea and atrial flutter, respectively. The remaining 14 patients were asymptomatic and their tumors were incidental findings. In 15 patients the valve was preserved. There was neither surgical mortality nor recurrence after 2.6 years of follow-up. In conclusion, most papillary fibroelastomas can be surgically removed with valve preservation and favorable clinical outcome. However, until the results of randomized trials support the decision, an aggressive surgical approach in asymptomatic patients needs to be defined in the context of surgical expertise.

Humans , Male , Female , Adult , Middle Aged , Aged , Young Adult , Papillary Muscles/pathology , Fibroma/pathology , Heart Neoplasms/pathology , Retrospective Studies , Fibroma/surgery , Heart Neoplasms/surgery
Rev. bras. cir. cardiovasc ; 32(3): 225-227, May-June 2017. tab, graf
Article in English | LILACS | ID: biblio-897916


Abstract Melanoma is a tumor that virtually involves any tissue and commonly metastasizes to the heart. It is usually not diagnosed because of the absent/nonspecific cardiac signs and symptoms. Herein, we present a case of a 41-year-old man without any cardiovascular risk factor, admitted to the emergency room with chest pain, diagnosed with a myocardial infarction. Due to the presence of a mass adjacent to the mitral valve on the cardiac ultrasound examination, causing mitral regurgitation, the patient was referred to surgery. Pathological analysis of the excised specimens diagnosed the melanoma. The chemotherapy was started and achieved a partial response. Cardiac metastases usually affect the myocardium, leaving the valves unaffected. In this case, the acute coronary syndrome was the first manifestation of the malignant melanoma. We highlight the high level of suspicion needed in these cases.

Humans , Male , Adult , Acute Coronary Syndrome/pathology , Heart Neoplasms/pathology , Heart Neoplasms/secondary , Melanoma/pathology , Melanoma/secondary , Immunohistochemistry , Echocardiography , Treatment Outcome , Diagnosis, Differential , Acute Coronary Syndrome/diagnostic imaging , Heart Neoplasms/surgery , Heart Neoplasms/diagnostic imaging , Melanoma/surgery , Melanoma/diagnostic imaging , Mitral Valve/surgery , Mitral Valve/pathology
Rev. bras. cir. cardiovasc ; 32(3): 228-230, May-June 2017. tab, graf
Article in English | LILACS | ID: biblio-897906


Abstract The development of left atrial myxoma after coronary artery bypass graft surgery is a rare entity. A 60-year-old man with previous off-pump coronary artery bypass grafting four years ago with patent coronary grafts was diagnosed with left atrial mass. The patient underwent successful resection of the same through minimally invasive right anterolateral thoracotomy. Histopathology of the atrial mass confirmed the diagnosis of atrial myxoma.

Humans , Male , Middle Aged , Coronary Artery Bypass/adverse effects , Heart Neoplasms/etiology , Heart Neoplasms/pathology , Myxoma/etiology , Myxoma/pathology , Reoperation , Time Factors , Cardiopulmonary Bypass/methods , Tomography Scanners, X-Ray Computed , Treatment Outcome , Sternotomy/methods , Heart Atria/pathology , Heart Neoplasms/surgery , Myxoma/surgery