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1.
Arq. bras. cardiol ; 117(4): 626-636, Oct. 2021. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1345231

ABSTRACT

Resumo Fundamento: Estudos epidemiológicos recentes demonstraram que alterações na microbiota e seus metabólitos estão associadas à hipertensão arterial sistêmica. A Helicobacter pylori (H. pylori) é um dos patógenos bacterianos mais comuns, e a possível associação entre a infecção por H. pylori e a hipertensão é controversa. Objetivos: Este estudo teve o objetivo de esclarecer a associação entre eles e proporcionar uma nova base teórica para detectar a patogênese da hipertensão. Métodos: Foram selecionados estudos caso-controle e transversais sobre a associação entre H. pylori e hipertensão, publicados de 1996 a 2019 indexados nos bancos de dados PubMed, Google Scholar, Chinese Wan Fang Data, e Chinese National Knowledge Infrastructure (CNKI). As razões de chance (RC) combinadas e o intervalo de confiança (IC) 95% foram estimados. O I² foi realizado para avaliar a heterogeneidade estatística. O viés de publicação foi avaliado utilizando-se os testes de Beggs e de Egger. Os dados extraídos foram analisados no software Stata 12.0. A significância estatística foi definida com um p-valor < 0,05. Resultados: Foram cadastrados 17 estudos envolvendo 6376 casos de hipertensão e 10850 controles. A taxa de infecção por H. pylori em pacientes hipertensos e em controles foi de 64,9% e 56,3%, respectivamente. Foi demonstrada uma associação significativamente positiva entre a infecção por H. pylori e a hipertensão, com uma RC global de 2,07 (IC 95%: 1,46-2,94; p < 0,05). A análise de subgrupos revelou que a prevalência de infecção por H. pylori foi associada à hipertensão na região da Ásia e no grupo de caso-controle, as RC (IC 95%) foram 2,26 (1,51-3,38) e 2,53 (1,72-3,72), respectivamente. Depois de estratificar por métodos de detecção, ainda existiam diferenças entre os subgrupos (todos p < 0,05). Conclusão: Esta metanálise indicou que a infecção por H. pylori está associada positivamente à hipertensão.


Abstract Background: Recent epidemiological studies have shown that alterations in microbiota and its metabolites are associated with systemic arterial hypertension. Helicobacter pylori (H. pylori) is one of the most common bacterial pathogens, and the potential association between H. pylori infection and hypertension are controversial. Objective: This study aimed to clarify their association and provide a new theoretical basis for uncovering the pathogenesis of hypertension. Methods: Case-control and cross-sectional studies on the association between H. pylori and hypertension published from 1996 to 2019 indexed in PubMed, Google Scholar, Chinese Wan Fang Data, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (OR) and 95% confidence interval (CI) were estimated. I2 was performed to evaluate the statistical heterogeneity. Publication bias was evaluated using Begg's and Egger's test. The extracted data was analyzed in Stata 12.0. Statistical significance was defined as p-value < 0.05. Results: A total of 17 studies involving 6,376 cases of hypertension and 10,850 controls were enrolled. H. pylori infection rate in hypertension patients and controls were 64.9% and 56.3%, respectively. A significantly positive association was shown between H. pylori infection and hypertension with an overall OR of 2.07 (95% CI: 1.46-2.94; p < 0.05). Subgroup analysis revealed that the prevalence of H. pylori infection was associated with hypertension in the region of Asia and the case-control group, ORs (95% CI) were 2.26 (1.51-3.38) and 2.53 (1.72-3.72), respectively. After stratifying by detection methods, differences still existed in subgroups (all p < 0.05). Conclusion: This meta-analysis indicated that H. pylori infection is positively associated with hypertension.


Subject(s)
Humans , Hypertension/epidemiology , Odds Ratio , Cross-Sectional Studies , Helicobacter pylori , Helicobacter Infections/complications , Helicobacter Infections/epidemiology
2.
Ciênc. Saúde Colet ; 26(supl.3): 5109-5121, Oct. 2021. tab
Article in Portuguese | LILACS | ID: biblio-1345764

ABSTRACT

Resumo Infecções crônicas podem contribuir com o processo de envelhecimento, mas isso ainda é pouco explorado na América Latina. O objetivo foi avaliar a prevalência e os fatores associados ao citomegalovírus (CMV), Herpes simples 1 (HSV-1), Chlamydia pneumoniae e Helicobacter pylori entre idosos. Participaram 1.320 indivíduos da linha de base da Coorte de Idosos de Bambuí. Foram avaliados anticorpos (IgG) para as infecções e variáveis exploratórias (sociodemográficas, comportamentos em saúde e condições de saúde). Utilizaram-se modelos de regressão de Poisson com variância robusta. A prevalência foi de 99,4% para CMV, 96,7% para HSV-1, 56,0% para C. pneumoniae e 70,5% para H. pylori. Os mais velhos, mulheres, fumantes, diabéticos, incapazes e com maiores níveis de IL-6 tinham maior prevalência de CMV. HSV-1 foi menos frequente entre as mulheres. Infecção por C. pneumoniae foi maior entre os mais velhos e diabéticos; e menor entre mulheres e os menos escolarizados. H. pylori foi menos frequente entre as mulheres e naqueles com maiores níveis de IL-1β, mas mais comuns entre os fumantes. Os achados mostram elevada prevalência de infecções crônicas e diferentes perfis epidemiológicos para cada patógeno, permitindo a detecção de grupos vulneráveis a essas infecções.


Abstract Chronic infections can contribute to the aging process, but this issue is less studied in Latin America. The aim was to assess the prevalence and factors associated with cytomegalovirus (CMV), Herpes Simplex 1 (HSV-1), Chlamydia pneumoniae and Helicobacter pylori among the elderly. A total of 1,320 individuals participated from the baseline of the Elderly Cohort of Bambuí. IgG antibodies against infections and explanatory variables (sociodemographic factors, health behaviors and health conditions) were evaluated. Poisson regression models with robust variance were used. Seroprevalence rates were 99.4% for CMV, 96.7% for HSV-1, 56% for C. pneumoniae and 70.5% for H. pylori. Elderly men, women, smokers, diabetics, the disabled and those with high levels of IL-6 had a higher prevalence of CMV. HSV-1 was less frequent among women. The prevalence of C. pneumoniae was higher at ages >75 and among diabetics; it was lower among women and individuals with less schooling. H. pylori was less frequent among women and those with detectable levels of IL-1β, but more common among smokers. The findings show a high prevalence of chronic infection and a different epidemiologic profile for each pathogen, making it possible to detect groups that are vulnerable to these infections.


Subject(s)
Humans , Male , Female , Aged, 80 and over , Helicobacter pylori , Helicobacter Infections/epidemiology , Chlamydophila pneumoniae , Seroepidemiologic Studies , Independent Living
3.
Rev. cuba. med. gen. integr ; 37(1): e1288, tab
Article in Spanish | LILACS, CUMED | ID: biblio-1280311

ABSTRACT

Introducción: La infección por H. pylori es considerada como la enfermedad bacteriana crónica más prevalente en el ser humano, pues infecta a más del 50 por ciento de la población mundial. Objetivo: Describir las características clínico epidemiológicas de la infección por H. pylori en pacientes con diagnóstico endoscópico de úlcera péptica. Métodos: Estudio descriptivo realizado en el Policlínico Camilo Cienfuegos; durante el año 2018, en 42 pacientes de 18 y más años, con diagnóstico endoscópico de úlcera péptica e informe del resultado de estudio histológico para el diagnóstico de infección por H. pylori. Se revisaron las historias clínicas y se confeccionó una planilla de recolección de datos que incluyó las variables: grupo de edades, sexo, manifestaciones clínicas, tipo de úlcera, número de lesiones, úlcera activa y metaplasia intestinal. Se utilizó la media y la desviación estándar (DE) y se identificaron los límites de clases superior e inferior. Se calcularon los porcentajes con IC = 95 por ciento. Se estimó la prevalencia general y específica de infección por H. pylori por grupo de edades y sexo. Resultados: El promedio de edad fue de 46,7 años ± 12,02 años. La prevalencia fue de 59,5 por ciento, superior en mayores de 65 años y en hombres. Conclusiones: El estudio permitió describir las características clínico epidemiológicas de la infección por H. pylori en pacientes con diagnóstico endoscópico de úlcera péptica. Fue más frecuente la presencia de síndrome dispéptico, con una única úlcera duodenal en fase activa y sin metaplasia intestinal(AU)


Introduction: Helicobacter pylori infection is considered the chronic bacterial disease most prevalent in humans, since it infects more than 50% of the world population. Objective: To describe the clinical-epidemiological characteristics of H. pylori infection in patients with an endoscopic diagnosis of peptic ulcer. Methods: Descriptive study carried out at Camilo Cienfuegos Polyclinic, during 2018. The study included 42 patients aged 18 and over who had an endoscopic diagnosis of peptic ulcer and a histological study result positive for H. pylori infection. The medical records were reviewed and a data collection form was prepared, which included the following variables: age group, sex, clinical manifestations, type of ulcer, number of lesions, active ulcer, and intestinal metaplasia. The mean and standard deviation (SD) were used, and the upper and lower class limits were identified. The percentages were calculated, with confidence interval at 95 percent. The general and specific prevalence of H. pylori infection was estimated by age group and sex. Results: The mean age was 46.7 years ± 12.02 years. The prevalence was 59.5 percent, higher among those over 65 years of age and among men. Conclusions: The study permitted to describe the clinical-epidemiological characteristics of H. pylori infection in patients with an endoscopic diagnosis of peptic ulcer. The presence of dyspeptic syndrome was more frequent, with a single duodenal ulcer in the active phase and no intestinal metaplasia(AU)


Subject(s)
Humans , Male , Female , Peptic Ulcer/complications , Endoscopy, Digestive System/methods , Helicobacter Infections/epidemiology , Epidemiology, Descriptive , Cross-Sectional Studies
4.
Arq. gastroenterol ; 58(1): 114-119, Jan.-Mar. 2021. tab, graf
Article in English | LILACS | ID: biblio-1248992

ABSTRACT

ABSTRACT Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and lymphoma. Epidemiological and experimental studies suggest that H. pylori chronic infection may be related to different extragastric diseases, including colorectal neoplasms. This concise review aims to explore the association of H. pylori infection with colorectal cancer and adenoma, including the recent epidemiological findings, the diagnostic methods employed to detect H. pylori and virulent factors, and the potentially involved mechanisms. Furthermore, is attempted to establish the current data integration for causal inference using the Bradford-Hill causality criteria. The weak, although global, strength of the epidemiological positive association between H. pylori infection and colonic neoplasms associated to new mechanisms postulated to explain this interaction, including intestinal dysbiosis, should stimulate future studies. Prospective confirmatory studies to establish the role of H. pylori eradication in the process of carcinogenic transformation of the colonic epithelium may define its eventual role in the treatment and prevention of colonic neoplasms.


RESUMO Helicobacter pylori é o principal agente etiológico dos tumores malignos causados por doenças infecciosas. Constitui fator importante, às vezes dominante, na patogênese de um amplo espectro de doenças como gastrite aguda e crônica, úlceras gástricas e duodenais, carcinoma gástrico e linfoma. Estudos epidemiológicos e experimentais sugerem que a infecção crônica por H. pylori pode estar relacionada a diferentes doenças extragástricas, incluindo neoplasias colorretais. Esta concisa revisão tem como objetivo explorar a associação da infecção por H. pylori com câncer colorretal e adenoma, incluindo os recentes achados epidemiológicos, os métodos de diagnóstico empregados para detectar H. pylori e seus fatores de virulência com os mecanismos potencialmente envolvidos nesta relação. Além disso, procura-se estabelecer a integração dos dados atuais na busca de inferência causal com o emprego dos critérios de causalidade de Bradford-Hill. A associação epidemiológica positiva entre infecção por H. pylori e neoplasias do cólon embora classificada como fraca - porém global - do ponto de vista epidemiológico, quando associada a mecanismos recentemente postulados para explicar essa interação, incluindo disbiose intestinal, deverá estimular a realização de investigações futuras. Estudos prospectivos confirmatórios para estabelecer o papel da erradicação do H. pylori no processo de transformação carcinogênica do epitélio do cólon são aguardados para definir seu eventual papel no tratamento e prevenção de neoplasias do cólon.


Subject(s)
Humans , Stomach Neoplasms/etiology , Stomach Neoplasms/epidemiology , Colorectal Neoplasms/etiology , Colorectal Neoplasms/epidemiology , Helicobacter pylori , Helicobacter Infections/complications , Helicobacter Infections/epidemiology , Gastritis , Prospective Studies
5.
Arq. gastroenterol ; 56(3): 264-269, July-Sept. 2019. tab, graf
Article in English | LILACS | ID: biblio-1038716

ABSTRACT

ABSTRACT BACKGROUND: It is widely assumed that gender, age, gastritis and Helicobacter pylori , all have some degree of correlation and, therefore, can synergistically lead to the development of gastric cancer. OBJECTIVE: In this cross-sectional study, we expected to observe the above mentioned correlation in the analysis of medical records of 67 patients of both sexes (female, n=44), mean age ± standard deviation: 41±12 years old, all from Belém (capital of Pará State, Brazilian Amazon), a city historically known as one with the highest gastric cancer prevalence in this country. METHODS: All patients were submitted to upper gastrointestinal endoscopy for gastric biopsy histopathological analysis and rapid urease test. All diagnoses of gastritis were recorded considering its topography, category and the degree of inflammatory activity, being associated or not associated with H. pylori infection. RESULTS: The results show that no statistically relevant associations were found among the prevalences of the observed variables. CONCLUSION: The authors hypothesize that observed risk factors associated to gastric cancer might be lesser synergistic than is usually expected.


RESUMO CONTEXTO: É amplamente assumido que gênero, idade, gastrite e Helicobacter pylori , todos têm algum grau de correlação e, portanto, podem sinergicamente levar ao desenvolvimento de câncer gástrico. OBJETIVO: Neste estudo transversal, esperamos observar a correlação acima mencionada na análise de prontuários de 67 pacientes de ambos os sexos (sexo feminino, n=44), média de idade ± desvio padrão: 41±12 anos, todos de Belém (capital do Estado do Pará, Amazônia Brasileira), uma cidade historicamente conhecida como sendo uma das que apresenta maior prevalência de câncer gástrico no país. MÉTODOS: Todos os pacientes foram submetidos à endoscopia digestiva alta para análise histopatológica da biópsia gástrica e teste rápido da urease. Todos os diagnósticos de gastrite foram registrados considerando sua topografia, categoria e grau de atividade inflamatória, sendo associada ou não associada à infecção por H. pylori . RESULTADOS: Os resultados mostram que não foram encontradas associações estatisticamente relevantes entre as prevalências das variáveis observadas. CONCLUSÃO: Os autores levantam a hipótese de que os fatores de risco associados ao câncer gástrico podem ser menos sinérgicos do que o esperado.


Subject(s)
Humans , Male , Female , Adult , Stomach Neoplasms/microbiology , Urease/analysis , Helicobacter Infections/complications , Gastric Mucosa/microbiology , Gastric Mucosa/pathology , Stomach Neoplasms/pathology , Stomach Neoplasms/epidemiology , Biopsy , Brazil/epidemiology , Sex Factors , Prevalence , Cross-Sectional Studies , Endoscopy, Digestive System , Helicobacter pylori , Helicobacter Infections/enzymology , Helicobacter Infections/epidemiology , Age Factors , Sex Distribution , Gastritis/microbiology , Gastritis/pathology , Intestinal Mucosa/enzymology , Middle Aged
6.
Rev. medica electron ; 41(4): 979-992, jul.-ago. 2019. tab
Article in Spanish | LILACS, CUMED | ID: biblio-1094102

ABSTRACT

RESUMEN La infección por helicobacter pylori afecta aproximadamente al 50% de la población mundial, es causante de gastritis crónica, úlcera péptica, cáncer gástrico y linfoma del tejido linfoide asociado a la mucosa. Desde su descubrimiento, la erradicación ha sido uno de los más importantes retos en Gastroenterología. En muchos países se desconoce la prevalencia de resistencia primaria del microorganismo a los diferentes antibióticos que empíricamente se utilizan, y por no realizar pruebas de rutina que verifican su erradicación en la práctica diaria, se ignora la efectividad de los esquemas prescritos. El incremento progresivo de la resistencia a la claritromicina y metronidazol, unido a una ausencia de antibioticoterapia alternativa, desafía la capacidad para eliminar de manera efectiva a ésta bacteria. El subcitrato de bismuto ha resurgido y su adición en la terapia ha permitido aumentar las tasas de curación por encima del 90%. Actualmente se invoca que para mejorar la eficacia en el tratamiento se debe combinar una supresión potente del ácido gástrico en tratamientos combinados cuádruples con una duración de 14 días, para la mayoría de los casos. La adherencia al tratamiento es crucial para obtener buenos resultados terapéuticos.


ABSTRACT The infection for helicobacter pylori affects approximately to the world population's 50%, it is causing of chronic gastritis, peptic ulcer, gastric cancer and linfoma associated to the mucous one. From their discovery, the eradication has been one of the most important challenges in Gastroenterología. In many countries the prevalencia of primary resistance is ignored from the microorganism to the different antibiotics that empirically they are used, and for not carrying out routine tests that verify its eradication in the daily practice, the effectiveness of the prescribed outlines it is ignored. The progressive increment of the resistance to the claritromicina and metronidazol, together to an absence of alternative antibioticotherapy, challenges the capacity to eliminate from an effective way to this bacteria. The bismuth subcitrato has resurged and its addition in the therapy has allowed to increase the cure rates above 90%. At the moment it is invoked that to improve the effectiveness in the treatment, that is should combine a potent suppression of the gastric acid in combined quadruple treatments with a duration of 14 days, for most of the cases. The adherence to the treatment is crucial to obtain therapeutic good results.


Subject(s)
Humans , Drug Resistance, Microbial , Risk Factors , Helicobacter Infections/etiology , Helicobacter Infections/drug therapy , Helicobacter Infections/epidemiology , Treatment Outcome , Drug Therapy, Combination , Disease Eradication , Peptic Ulcer/diagnosis , Stomach Neoplasms/diagnosis , Tetracycline/therapeutic use , Bismuth/therapeutic use , Adenocarcinoma/diagnosis , Clarithromycin , Lymphoma, B-Cell, Marginal Zone/diagnosis , Acidity Regulator , Proton Pump Inhibitors/therapeutic use , Treatment Adherence and Compliance , Gastritis/diagnosis , Gastroenterology , Metronidazole , Metronidazole/therapeutic use
7.
Rev. Hosp. Clin. Univ. Chile ; 30(1): 3-11, 2019. Tab., Graf.
Article in Spanish | LILACS | ID: biblio-1005532

ABSTRACT

Helicobacter pylori (HP) is the most widely chronic human infection around the world, and the main risk factor for the development of gastric cancer. Our country has high rates of this neoplasia and a high prevalence of HP infection. Even both have fallen in the last year, is a major concern to diagnose the population infected with HP in early stages, before the development of premalignant lesions and properly eradicate this infection. In this review, we discussed the different methods for the diagnosis of HP and factors that change positivity as the use of proton pump inhibitors. Also, we discussed the factors to be considered in the choice of the treatment, like local resistance to antibiotics, specially clarithromycin. In the last years has been documented in Chile a significant increase in resistance to clarithromycin, from 20 to 46%, which predicts inadequate effectiveness for the classic triple therapy. As the result of the previous analysis we discussed new possible therapies, including bismuth quadruple therapy and concomitant therapy. (AU)


Subject(s)
Humans , Male , Female , Helicobacter pylori , Helicobacter pylori/pathogenicity , Helicobacter Infections/diagnosis , Helicobacter Infections/therapy , Helicobacter Infections/epidemiology
9.
Rev. cuba. pediatr ; 90(3): 1-10, jul.-set. 2018. ilus, tab
Article in Spanish | LILACS, CUMED | ID: biblio-978449

ABSTRACT

Introducción: la infección por Helicobacter pylori es muy común, particularmente en los países en vías de desarrollo, y juega un rol importante en la enfermedad ácido péptica. Objetivos: conocer la prevalencia y algunos datos clínico epidemiológicos, describir los hallazgos endoscópicos (gastritis eritematosa, nodular y úlcera duodenal), y relacionarlos con los hallazgos histológicos; describir la asociación entre los grados histológicos de la gastritis crónica y la positividad de la prueba de ureasa rápida y la presencia de Helicobacter pylori según histología, así como identificar la relación de los pacientes con gastritis crónica antral y úlcera duodenal por Hp, con la edad. Métodos: se realizó un estudio tipo descriptivo prospectivo durante 3 años se hizo una encuesta de síntomas a pacientes y/o padres y examen físico. Se realizó panendoscopia, previo consentimiento informado, y 2 biopsias de mucosa antral para prueba de ureasa rápida, así como estudio histopatológico (hematoxilina-eosina y Giemsa) para determinar el grado de gastritis y presencia de Helicobacter pylori según sistema Sydney. Se demostró la infección por uno de los métodos. Resultados: se seleccionaron 196 pacientes entre 7-18 años (media 14,6) de 471 (41,6 por ciento). El 53 por ciento era del sexo femenino, y el 59,7 por ciento tenía entre 10 y 14 años. Por endoscopia, el 49,5 por ciento tenía gastritis eritematosa antral, el 36,8 por ciento gastritis nodular astral, y el 13,7 por ciento úlcera duodenal con gastritis asociada. Con antecedentes familiares de úlcera péptica estuvo el 29,6 por ciento, con epigastralgia el 85,2 por ciento, con acidez el 46,4 por ciento con vómitos el 21 por ciento y con náuseas el 16,3 por ciento. En relación con el tiempo de evolución al diagnóstico, predominó el grupo de más de un año (24,5 por ciento), seguido del de 4-6 meses (22,4 por ciento). Todos presentaron gastritis crónica de diferentes grados: ligera (34,7 por ciento), moderada (37,2 por ciento) y severa (28,1 por ciento), con Helicobacter pylori por ureasa rápida 83,2 por ciento y 93,4 por ciento por histología, con coincidencia de ambos métodos en 150 (76,5 por ciento). Se observó presencia de nódulos linfoides en 41,8 por ciento. Conclusiones: la infección por Helicobacter pylori es frecuente en niños y adolescentes, causa lesiones inflamatorias gastroduodenales, en particular, gastritis nodular antral. Se encuentra una asociación importante del Helicobacter pylori por ambos métodos diagnósticos. Se recomienda seguimiento por biopsia, en especial, a los que continúan con infección crónica y presenten nódulos linfoides, por el riesgo de presentar linfoma gástrico de células B del tejido linfoide asociado a mucosa (linfoma MALT), si no se consigue la erradicación del Helicobacter pylori(AU)


Introduction: Helicobacter pylori infection is very common, particularly in developing countries, and plays an important role in acid peptic disease. Objectives: to know the prevalence and some clinical epidemiological data for describing the endoscopic findings (erythematous gastritis, nodular and duodenal ulcer), and to relate them with the histological findings; to describe the association among the histological degrees of chronic gastritis and the positivity of the rapid urease test, and the presence of Helicobacter pylori according to histology, as well as identifying by Hp with age the number of patients with chronic antral gastritis and duodenal ulcer. Methods: a prospective, descriptive study was carried out during 3 years, and a survey of symptoms was made to patients and / or parents and also physical examination. Panendoscopy was performed with prior informed consent, and also 2 antral mucosa biopsies for rapid urease test, as well as histopathological study (hematoxylin-eosin and Giemsa) to determine the degree of gastritis and the presence of Helicobacter pylori according to the Sydney system. Infection was demonstrated by one of the methods. Results: 196 patients among 7-18 years (mean 14.6) were selected of 471 (41.6 percent). 53 percent were female, and 59.7 percent were among 10 and 14 years old. By endoscopy, 49.5 percent had antral erythematous gastritis, 36.8 percent astral nodular gastritis, and 13.7 percent duodenal ulcer with associated gastritis. 29.6 percent had a family history of peptic ulcer, 85.2 percent of epigastralgia, 46.4 percent with acidity, 21 percent with vomiting, and 16.3 percent with nausea. In relation to the time of evolution to the diagnosis, the group of more than one year prevailed (24.5 percent followed by the one of 4-6 months (22.4 percent). All presented chronic gastritis of different degrees: light (34.7 percent), moderate (37.2 percent) and severe (28.1 percent), with Helicobacter pylori by rapid urease 83.2 percent, and 93.4 percent by histology with coincidence of both methods in 150 (76.5 percent). The presence of lymphoid nodules was observed in 41.8 percent. Conclusions: Helicobacter pylori infection is frequent in children and adolescents causing gastroduodenal inflammatory lesions, in particular antral nodular gastritis. An important association of Helicobacter pylori is found by both diagnostic methods. Follow-up by biopsy is recommended, especially those who continue with chronic infection and have lymphoid nodules due to the risk of presenting B-cell gastric lymphoma of the lymphoid tissue associated to the mucosa (MALT lymphoma), if Helicobacter pylori eradication is not achieved(AU)


Subject(s)
Humans , Male , Female , Child , Adolescent , Helicobacter Infections/epidemiology , Helicobacter Infections/diagnostic imaging , Gastritis/complications , Epidemiology, Descriptive , Prospective Studies , Helicobacter pylori/pathogenicity
10.
Rev. méd. Chile ; 146(5): 555-561, mayo 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-961431

ABSTRACT

Background: Helicobacter pylori (HP) is the most widespread chronic human infection worldwide and the most important pathogenic factor of gastric cancer. The calculated prevalence at the Clinical Hospital of the University of Chile from 2002 to 2005 was 44.9%. Aim: To determine the current prevalence of HP in patients undergoing an upper gastrointestinal endoscopy (UGI) and analyze its distribution according to age and endoscopic findings. Material and Methods: We reviewed 3.433 UGI performed during the year 2015, selecting those in which rapid urease test (RUT) was done. A positive RUT or a positive gastric biopsy (GB) were considered as HP infection. Results: RUT was done in 1862 UGI (55%) performed in patients aged 51 ± 17 years, (66% women). In 23% of these endoscopies, the RUT was positive. A GB was obtained 43% of endoscopies and 30% were positive for HP. In 105 patients the RUT was negative and the GB positive (rendering a 19.5% false negative rate). HP was detected by RUT and GB in 29% of endoscopies. The highest prevalence of infection (38.1%) was found between 40 and 49 years. HP infection had odds ratio of 4.24 for nodular gastropathy, 2.63 for gastric ulcer and 2.14 for duodenal ulcer (p < 0.05). Conclusions: HP prevalence in our center decreased significantly from 44.9% to 28.9% in 11 years. False negative RUT results may bias this finding. The use of proton pump inhibitors and antimicrobials that can interfere with the detection of HP should be registered to properly analyze the results of the RUT.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Young Adult , Helicobacter pylori/isolation & purification , Helicobacter Infections/diagnosis , Gastrointestinal Diseases/microbiology , Biopsy , Chile/epidemiology , Prevalence , Cross-Sectional Studies , Retrospective Studies , Endoscopy, Gastrointestinal , Helicobacter Infections/epidemiology , Age Distribution , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/epidemiology
11.
Rev. medica electron ; 40(2): 433-444, mar.-abr. 2018. ilus
Article in Spanish | LILACS, CUMED | ID: biblio-902310

ABSTRACT

RESUMEN La Organización Mundial de la Salud señala que el cáncer gástrico es una neoplasia frecuente en el mundo contemporáneo. Constituye la segunda causa de muerte en el hombre y la tercera en las mujeres. Numerosos son los factores de riesgo que se asocian con la aparición del cáncer gástrico, en determinadas regiones del mundo. El descubrimiento del Helicobacter pylori y la asociación con las enfermedades gastroduodenales ha revolucionado los aspectos fisiopatológicos y terapéuticos hasta el punto de considerar la bacteria como agente precursor del cáncer gástrico. Por tal motivo se realizó una revisión de los factores de riesgo y el papel del Helicobacter pylori en la formación de la neoplasia gástrica, con el objetivo de aportar conocimientos relacionados con el cáncer gástrico y su prevención (AU).


ABSTRACT The World Health Organization points out that gastric cancer is a frequent neoplasia in the contemporary world. It is the second cause of death in men and the third one in women. There are several risk factors associated to the development of gastric cancer in specific regions of the world. The discovery of Helicobacter pylori and its association to gastro duodenal diseases has renewed the physiopathological and therapeutic aspects up to the point of considering the bacteria as precursor agent of gastric cancer. For that cause, it was carried out a review of the risk factors and the role of Helicobacter pylori in the formation of gastric neoplasia, with the objective of giving out knowledge related to gastric cancer and its prevention (AU).


Subject(s)
Humans , Stomach Neoplasms/diagnosis , Stomach Neoplasms/mortality , Stomach Neoplasms/prevention & control , Stomach Neoplasms/epidemiology , Risk Factors , Helicobacter Infections/complications , Helicobacter Infections/etiology , Helicobacter Infections/epidemiology , Preventive Health Services , Bibliography of Medicine , Developed Countries , Indicators of Morbidity and Mortality , Epidemiologic Methods , Helicobacter pylori , Developing Countries , Health Promotion
12.
Middle East Journal of Digestive Diseases. 2018; 10 (1): 5-17
in English | IMEMR | ID: emr-192419

ABSTRACT

Helicobacter pylori [H. pylori] infection is one of the most common bacterial infections, affecting almost half of the world's population. It is associated with peptic ulcer disease, gastric adenocarcinoma, and lymphoma. In Iran, the prevalence of H. pylori infection has been reported to be between 36% and 90% in different geographic regions. Several studies have assessed the efficacy of different therapeutic options for first line and second-line H. pylori eradication in Iran; however, the results are conflicting. Therefore, we conducted a review to evaluate different studies in order to select the best options and to provide recommendations for H. pylori eradication in Iran. Accordingly, we searched through PubMed to obtain relevant randomized clinical trials published in English language up to June 2017. According to our study, among first-line eradication regimens, bismuth-based furazolidone-or clarithromycin-containing quadruple therapies, hybrid regimen, and concomitant therapy seem to be appropriate options. Also, 10- or 14-day clarithromycin-containing triple therapy can be used if local H. pylori resistance to clarithromycin is known to be less than 15%. For second-line H. pylori eradication, bismuth-based quadruple therapies and 14-day levofloxacin-based triple therapy can be used, provided that antibiotics other than those used in the first-line regimen are used. Third-line H. pylori eradication regimens have not been addressed in Iranian studies. However, most guidelines recommend treatment according to the results of culture and susceptibility testing. Although we limited our investigation to H. pylori eradication regimens in Iran, the results are transferrable to any region as long as the patterns of antibiotic resistance are the same


Subject(s)
Humans , Helicobacter Infections/epidemiology , Disease Eradication , Helicobacter pylori , Helicobacter Infections/drug therapy
13.
Gastroenterol. latinoam ; 29(supl.1): S13-S20, 2018. ilus, graf
Article in Spanish | LILACS | ID: biblio-1117577

ABSTRACT

H. pylori infection is a fascinating history, which combines the roles as one of the most prevalent commensal and a a pathogen responsible for severe diseases, some of them unimaginable until the end of last century, such as gastric cancer. In this review we present the available evidence that might help to identify the main mode of transmission of H. pylori and we discuss which could be the potential approaches to prevent the transmission of this bacterium in countries with high and low prevalence.


La infección por Helicobacter pylori es una historia fascinante, en donde se combinan el papel de un comensal con el de un patógeno humano que produce enfermedades graves, algunas inimaginables hasta hace menos de 30 años, como es el caso de cáncer gástrico. En esta revisión discutimos las evidencias disponibles en función de la prevalencia e incidencia de H. pylori tanto en países económicamente desarrollados como en proceso de desarrollo y tratamos de establecer cuál es el principal modo de transmisión de este organismo. Finalmente, se discuten cuáles pueden ser las mejores medidas de prevención, tanto en países con baja prevalencia como en aquellos con una alta prevalencia.


Subject(s)
Humans , Helicobacter Infections/prevention & control , Helicobacter Infections/transmission , Global Health , Incidence , Helicobacter pylori/pathogenicity , Helicobacter Infections/epidemiology
14.
Rev. chil. cir ; 69(6): 502-507, dic. 2017.
Article in Spanish | LILACS | ID: biblio-899645

ABSTRACT

Resumen El cáncer gástrico es uno de los cánceres más frecuentes en el mundo. Recientes estudios han contribuido en la comprensión de esta enfermedad. El objetivo de este artículo es revisar de manera crítica y actualizada distintos aspectos del cáncer gástrico tanto a nivel mundial como a nivel chileno. Este artículo revisa algunos aspectos relacionados con el cáncer gástrico, tales como epidemiología, dieta, estudio histológico, búsqueda de lesiones precancerosas, prevención, Helicobacter pylori, estilos de vida, factores metabólicos y tratamiento.


Abstract Gastric cancer is one of the most common cancers in the world. Recent studies have contributed to the understanding of this disease. The aim of this article is to critically review various aspects of gastric cancer both globally and Chilean. This article reviews some aspects related to gastric cancer, such as epidemiology, diet, histology, screening of precancerous lesions, prevention, Helicobacter pylori, lifestyles, metabolic factors and treatment.


Subject(s)
Humans , Stomach Neoplasms/therapy , Stomach Neoplasms/epidemiology , Precancerous Conditions/epidemiology , Stomach Neoplasms/prevention & control , Chile , Global Health , Helicobacter Infections/epidemiology , Life Style
15.
Rev. méd. Maule ; 33(1): 8-13, jun. 2017. tab
Article in Spanish | LILACS | ID: biblio-1283791

ABSTRACT

BACKGROUND: The clinical outcome of Helicobacter pylori (H. pylori) infection has been related to the presence of CagA protein. This protein is highly polymorphic and its oncogenic ability depends on the number and type of tyrosine phosphorylation sites in the EPIYAs repeat sequences (A, B, C and D). AIM: To determine the EPIYA patterns of the CagA gene in H. pylori strains and its relationship with gastrointestinal pathology in infected patients of the Regional Hospital of Talca. MATERIAL AND METHODS: The strains were isolated from gastric biopsies and characterized by bacteriological and molecular methods. Gastrointestinal pathology was characterized by histopathological analysis. For the determination of the presence of the cagA gene and the EPIYAs standards, the conventional PCR technique was used. RESULTS: 138 DNA samples from H. pylori strains were analyzed. 92.0% (127/138) of the isolates carried the cagA gene, of which 66 (52.0%) corresponded to the EPIYA-ABC pattern, 43 (33.8%) to the EPIYA-ABCC pattern and 21 16.5%) to the EPIYA-ABCCC phosphorylation pattern. 50.4% (64/127) of cagA positive strains isolated from dyspeptic patients in the Maule region have more than two C sites of phosphorylation. The number of EPIYAs C motifs was associated with the presence of more severe histopathological damage in the gastric mucosa.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Stomach Neoplasms/microbiology , Stomach Neoplasms/pathology , Helicobacter pylori/genetics , Helicobacter Infections/microbiology , Helicobacter Infections/pathology , Amino Acid Motifs , Stomach Neoplasms/epidemiology , Bacterial Proteins/genetics , Biopsy , DNA, Bacterial/genetics , DNA, Bacterial/chemistry , Chile/epidemiology , Epidemiology, Descriptive , Endoscopy, Digestive System , Helicobacter Infections/epidemiology , Ethics Committees , Sequence Analysis, DNA , Antigens, Bacterial/genetics
16.
Säo Paulo med. j ; 135(2): 140-145, Mar.-Apr. 2017. tab
Article in English | LILACS | ID: biblio-846288

ABSTRACT

ABSTRACT CONTEXT AND OBJECTIVE: The prevalence of Helicobacter pylori infection is unevenly distributed among different populations. The aim here was to evaluate the factors associated with Helicobacter pylori infection among children up to five years of age living in a high-risk community. DESIGN AND SETTING: Cross-sectional study in an indigenous community of Guarani Mbya ethnicity, Tekoa Ytu and Tekoa Pyau villages, Jaraguá district, city of São Paulo (SP), Brazil. METHODS: 74 children aged 0.4 to 4.9 years (mean 2.9 ± 1.3 years; median 3.1), and 145 family members (86 siblings, 43 mothers and 16 fathers) were evaluated for Helicobacter pylori infection using the validated 13C-urea breath test. Clinical and demographic data were collected. RESULTS: The prevalence was 8.3% among children aged 1-2 years and reached 64.3% among those aged 4-5 years (P = 0.018; overall 31.1%). The prevalence was 76.7% among siblings and 89.8% among parents. There was a negative association with previous use of antibiotics in multivariate analysis adjusted for age (odds ratio, OR: 0.07; 95% confidence interval, CI: 0.01 to 0.66; P = 0.02). The prevalence was higher among males (OR: 1.55), and was associated with maternal infection (OR: 1.81), infection of both parents (OR: 1.5), vomiting (OR: 1.28), intestinal parasitosis (OR: 2.25), previous hospitalization (OR: 0.69) and breastfeeding (OR: 1.87). CONCLUSIONS: The prevalence was high among subjects older than three years of age, thus suggesting that the incidence of infection was higher over the first three years of life. Previous use of antibiotics was inversely associated with current Helicobacter pylori infection.


RESUMO CONTEXTO E OBJETIVO: A prevalência da infecção pelo Helicobacter pylori é desigualmente distribuída entre diferentes populações. O objetivo foi avaliar fatores associados à infecção pelo Helicobacter pylori em crianças de até cinco anos de idade morando numa comunidade de alto risco. TIPO DE ESTUDO E LOCAL: Estudo transversal na comunidade indígena da etnia Guarani Mbya das aldeias Tekoa Ytu e Tekoa Pyau do distrito de Jaraguá da cidade de São Paulo (SP), Brasil. MÉTODOS: 74 crianças de 0,4 a 4,9 anos (média 2,9 ± 1,3 anos; mediana 3,1), e 145 familiares (86 irmãos, 43 mães e 16 pais) foram avaliadas quanto à infecção pelo Helicobacter pylori com o teste respiratório com ureia 13C validado. Dados clínicos e demográficos foram coletados. RESULTADOS: Prevalência foi 8,3% entre 1-2 anos, atingindo 64,3% entre 4-5 anos (P = 0,018; 31,1% globalmente). Em irmãos, foi 76,7% e 89,8% nos pais. Observou-se associação negativa com uso prévio de antibiótico em análise multivariada ajustada para idade (odds ratio, OR: 0,07; intervalo de confiança, IC: 95%: 0,01-0,66; P = 0,02). A prevalência foi maior no sexo masculino (OR: 1,55), e foi associada a infecção materna (OR: 1,81), infecção de ambos os pais (OR: 1,5), vômitos (OR: 1,28), parasitose intestinal (OR: 2,25), hospitalização prévia (OR: 0,69) e aleitamento materno (OR: 1,87). CONCLUSÕES: A prevalência foi alta entre os indivíduos com mais de três anos de idade, o que sugere incidência maior nos três primeiros anos de vida. Uso prévio de antibióticos foi inversamente associado a infecção atual por Helicobacter pylori.


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Indians, South American , Helicobacter pylori/isolation & purification , Helicobacter Infections/epidemiology , Brazil/epidemiology , Prevalence , Cross-Sectional Studies , Risk Factors , Age Factors
17.
Article in English | AIM, AIM | ID: biblio-1262153

ABSTRACT

Background information Helicobacter pylori is a ubiquitous organism that causes infections that are asymptomatic, and with no specific clinical signs and symptoms. Various diagnostic tests for H. pylori have been developed. This study was intended to understand the prevalence of H. pylori among suspected peptic ulcer patients in a tertiary medical facility in Port Harcourt. Methodology The ninety-eight (98) patients who consented were properly instructed before being given a capsule containing urea. This was swallowed with 50mls of water and they waited for ten minutes, after which, they breathed into a breath card until the indicator changed colour from orange to yellow. The breath card was then inserted into a device which detects the production or otherwise of the carbon dioxide with isotopically labelled carbon by displaying positive if present or negative if absent.Result In this study, out of the forty-five male and fifty-three female subjects that participated in this study, a study prevalence of 39.8% was observed. Also, a male to female prevalence ratio of 15.3:24.5 was observed with no statistical significance (X2=0.1519, P=0.6911). Similarly, the age group distribution of H. pylori infection among the male population showed age group 41-50 years as the modal (11.6%) prevalence, followed by age group 51-60 years (9.3%) with P>0.05 (X2=3.478, P=0.7470). In the same vein, the female distribution of H. pylori infection revealed that there was no significance among the different study groups with P>0.05 (X2=3.115, P=0.7943) and age group 31-40 years (16.1%) had the modal prevalence. Conclusion The high incidence of H. pylori infection among suspected peptic ulcer patients in Port Harcourt has been established, though not as high as other studies elsewhere. Therefore, public enlightenment should be encouraged by all public health stakeholders to arrest this trend


Subject(s)
Helicobacter Infections/diagnosis , Helicobacter Infections/epidemiology , Helicobacter pylori , Nigeria , Peptic Ulcer
19.
Rev. chil. pediatr ; 87(6): 474-479, Dec. 2016. tab
Article in Spanish | LILACS | ID: biblio-844568

ABSTRACT

Introducción: La infección por H. pylori se adquiere tempranamente en la infancia. Sin embargo, existe escasa información acerca del rol de la lactancia materna y la adquisición de la bacteria en la etapa neonatal/lactante. Objetivo: Evaluar algunos factores que afectan la adquisición de H. pylori en recién nacidos y lactantes hijos de madres infectadas. Pacientes y método: Reclutamiento consecutivo de binomios madre-hijo en maternidad, inmediatamente posparto. Luego de la firma de consentimiento informado, se obtuvo una muestra de deposición de la madre, previo al alta. Posteriormente se obtuvieron 3 muestras de deposición de los recién nacidos/lactantes a los 15, 60 y 90 días de vida, para la detección de antígeno en deposición de H. pylori (HpSAg monoclonal, sensibilidad 94% y especificidad 97%). Además se registraron variables socio-epidemiológicas y biomédicas. Resultados: Se reclutaron 32 binomios madre-hijo, 64 sujetos. Promedio de edad materna de 30,1 ± 5,1 años, 53% parto eutócico, 85% con lactancia materna exclusiva al final del seguimiento. Se encontró 13 madres (40%) infectadas por H. pylori. No hubo infección por H. pylori en los recién nacidos y lactantes a los 3 meses de seguimiento. No hubo diferencia significativa en el nivel socioeconómico entre madres infectadas versus no infectadas (ambos grupos en nivel socioeconómico muy alto: 28% y 32% respectivamente, p = 0,15), ni en el número de habitantes por domicilio entre madres infectadas y no infectadas (3,8 ± 0,8 vs 4,2 ± 1,8 personas, p = 0,18). Conclusión: A pesar de tener un alto porcentaje de madres infectadas por H. pylori, no hubo recién nacidos/lactantes infectados al tercer mes de vida. El rol protector de la lactancia maternal no se puede descartar.


Introduction: H. pylori infection is acquired early in childhood. However, there is little information available regarding the role of breastfeeding and neonatal acquisition of the infection. Objective: To evaluate factors affecting the acquisition of H. pylori in newborns and infants from infected mothers. Patients and method: Consecutive mothers and their newborns were recruited into the study from the maternity unit, immediately after delivery. After signing informed consent, one stool sample from the mother was obtained before hospital discharge. Three stool samples of the newborns were then collected at home at 15, 60, and 90 days of life, for the detection of H. pylori antigen (Monoclonal HpSAg, sensitivity 94% and specificity 97%). The socio-epidemiological and biomedical variables were also analysed using a questionnaire. Results: A total of 32 mother-child pairs (64 subjects) were enrolled. The mean maternal age was 30.1 ± 5.1 years, with 53% vaginal delivery, and 85% exclusively breastfed. There were 13 (40%) infected mothers. No H. pylori infection was detected in newborns and infants up to 3 months of follow-up. No significant differences were found in socioeconomic level between infected versus non-infected mothers (both groups mostly in the very high socioeconomic category: 28% and 32%, respectively, P = .15) and in the number of family members between infected versus non-infected mothers (3.8 ± 0.8 vs 4.2 ± 1.8 persons, P = .18). Conclusion: Despite having a significant percentage of H. pylori-infected mothers, no newborn was infected at the third month of life. The protective role of breastfeeding cannot be ruled out.


Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Adult , Breast Feeding , Helicobacter pylori/isolation & purification , Helicobacter Infections/prevention & control , Infectious Disease Transmission, Vertical/prevention & control , Socioeconomic Factors , Time Factors , Surveys and Questionnaires , Follow-Up Studies , Helicobacter Infections/transmission , Helicobacter Infections/epidemiology , Sensitivity and Specificity
20.
ABCD arq. bras. cir. dig ; 29(3): 151-154, July-Sept. 2016. tab, graf
Article in English | LILACS | ID: lil-796947

ABSTRACT

ABSTRACT Background: Helicobacter pylori has been extensively studied since 1982 it is estimated that 50% of the world population is affected. The literature lacks studies that show the change of its prevalence in the same population over time. Aim: To compare the prevalence of H. pylori in 10 years interval in a population that was submitted to upper endoscopy in the same endoscopy service. Method: Observational, retrospective and cross-sectional study comparing the prevalence of H. pylori in two samples with 10 years apart (2004 and 2014) who underwent endoscopy with biopsy and urease. Patients were studied in three consecutive months of 2004, compared to three consecutive months of 2014. The total number of patients was 2536, and 1406 in 2004 and 1130 in 2014. Results: There were positive for H. pylori in 17 % of the sample as a whole. There was a significant decrease in the prevalence from 19.3% in 2004 to 14.1% in 2014 (p<0.005). Conclusion: There was a 5.2% reduction in the prevalence of H. pylori comparing two periods of three consecutive months with 10 years apart in two equivalent population samples.


RESUMO Racional: Helicobacter pylori vem sendo amplamente estudado desde 1982 estimando-se que 50% da população mundial esteja afetada. A literatura carece de estudos que mostrem a mudança de sua prevalência em uma mesma população ao longo do tempo. Objetivo: Comparar a prevalência do H.pylori no intervalo de 10 anos em população que realizou endoscopia digestiva alta no mesmo serviço de endoscopia. Método: Estudo observacional, retrospectivo e transversal, comparando a prevalência de H. pylori em duas amostras com intervalo de 10 anos (2004 e 2014) que realizaram endoscopia digestiva alta com biópsias e teste da urease para a pesquisa de H. pylori. Foram estudados pacientes em três meses consecutivos de 2004, comparados aos de três meses consecutivos de 2014. O número total de pacientes avaliados foi 2536, sendo 1406 em 2004 e 1130 em 2014. Resultados: Constatou-se resultado positivo para H.pylori em 17% da amostra como um todo. Houve queda significativa da prevalência de H.pylori de 19,3% em 2004 para 14,1% em 2014 (p<0.005). Conclusão: Houve redução de 5,2% da prevalência de H. pylori comparando-se dois períodos de três meses consecutivos com intervalo de 10 anos em duas amostras populacionais equivalentes.


Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Young Adult , Helicobacter pylori , Helicobacter Infections/epidemiology , Time Factors , Prevalence , Cross-Sectional Studies , Retrospective Studies , Endoscopy, Digestive System
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