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1.
An. bras. dermatol ; 97(1): 37-44, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360072

ABSTRACT

Abstract Background: Infantile hemangiomas (IH) occur in approximately 4% to 10% of the pediatric population. The identification of clinical subtypes and conditions that indicate increased risk for complications is essential for therapeutic success. Objectives: To identify risk factors for complications, recurrence and unaesthetic sequelae. Methods: Retrospective cohort of patients with infantile hemangiomas undergoing follow-up at the Dermatology Service of Universidade Federal de Ciências da Saúde de Porto Alegre, between 2006 and 2018. Results: 190 patients were included; 24% had some type of complication, ulceration being the most frequent, and 86% required treatment. On correlation, ulceration was statistically related to mixed IH (p = 0.004), segmental IH (p < 0.01) and location in the gluteal region (p = 0.001). The mean time of treatment with propranolol was 12.7 months. Patients with PHACES syndrome and segmental infantile hemangioma required longer treatment (p < 0.001 and p = 0.0407, respectively), as well as those who started treatment after five months of life (p < 0.0001). Recurrence occurred in 16.6% of the treated patients, all-female; 94% were located on the head and neck (mainly on the upper eyelid, cyrano, S3 segment, and with parotid involvement); 61% and 38.8% were of the mixed and deep subtypes, respectively. Approximately 1/3 of the patients had some unaesthetic sequelae. Study limitations: As this is a retrospective study, data and photos of some patients were lost. Conclusions: Mixed and segmental hemangiomas are risk factors for ulceration and sequelae. Recurrence occurs more often in females and segmental hemangiomas. Segmental infantile hemangioma and PHACES syndrome require a longer time of treatment. Specific protocols are required for infantile hemangiomas with a high risk of recurrence.


Subject(s)
Humans , Female , Infant , Child , Skin Neoplasms , Hemangioma/drug therapy , Hemangioma/epidemiology , Propranolol/therapeutic use , Retrospective Studies , Risk Factors , Treatment Outcome
4.
Rev. med. Risaralda ; 27(1): 92-95, ene.-jun. 2021. graf
Article in Spanish | LILACS, COLNAL | ID: biblio-1280498

ABSTRACT

Resumen Las malformaciones venosas son lesiones vasculares benignas infrecuentes que se presentan en el útero. Están conformadas por venas anormales, de diferentes tamaños y proporciones, con configuración espongiforme y disposición al azar. En la literatura, han sido previamente reportados algunos casos, usando el término "hemangioma cavernoso", pero según los cambios recientes en la terminología, aprobados por Sociedad Internacional para el Estudio de las Anormalidades Vasculares (ISSVA), se desaconseja el uso de este término y se sugiere el de "Malformación venosa", si se cumplen los hallazgos histopatológicos al momento de hacer el diagnóstico. Presentamos el caso de una mujer de 44 años, con cuadro de hemorragia vaginal anormal y diagnóstico clínico de miomatosis y mioma abortado por el orificio cervical interno, el estudio histopatológico reveló la presencia de una malformación venosa que comprometía el miometrio y endometrio, con formación subsecuente de un pólipo.


Abstract Venous malformations are benign vascular lesions that rarely appear in the uterus. They are made up of abnormal veins, of different sizes and proportions, with spongiform configuration and random disposition. In the literature, some cases have been previously reported, using the term "cavernous hemangioma", but according to recent changes in terminology, approved by the International Society for the Study of Vascular Abnormalities (ISSVA), the use of this term is discouraged, and the diagnosis of Venous malformation is suggested, if the histopathological findings are met. We present the case of a 44-year-old woman, with abnormal vaginal bleeding and a clinical diagnosis of myomatosis and myoma aborted by the internal cervical orifice, in whom the histopathological study revealed the presence of a venous malformation that compromised the myometrium and endometrium, with subsequent formation of a polyp.


Subject(s)
Humans , Female , Adult , Uterus , Vascular Malformations , Hemangioma, Cavernous , Uterus/pathology , Vascular System Injuries , Hemangioma , Morphogenesis
5.
Rev. argent. cir. plást ; 27(2): 100-105, 20210000. fig
Article in Spanish | LILACS, BINACIS | ID: biblio-1357920

ABSTRACT

Los labios son repliegues músculo membranosos móviles que se encuentran en la entrada de la cavidad oral, y tienen como funcionalidad proporcionar competencia para la cavidad oral durante la masticación y el reposo. Bozzola y cols., en 1989, describieron la arteria bucal como el principal pedículo para el músculo buccinador. El objetivo de este trabajo es demostrar la efectividad del colgajo miomucoso del buccinador para reconstrucción del labio inferior en un paciente con hemangioma congénito. Este es un estudio longitudinal de tipo retrospectivo, con resultado descriptivo, que se le realizó a un paciente masculino de 32 años, para cubrimiento de defecto de lesión en labio inferior secundario a hemangioma congénito utilizando la reconstrucción con colgajo miomucoso del buccinador. El colgajo miomucoso del buccinador o colgajo yugal se considera uno de los mejores colgajos locales para la reconstrucción del labio inferior, sea cual fuere la causa, por su fácil disección y versatilidad debido a que tiene una tasa de sobrevida muy elevada con mínimas complicaciones en el posoperatorio. Nuestros resultados obtenidos concuerdan con los resultados ya publicados por diferentes autores, que llegan a las mismas conclusiones; aunque existen varias técnicas con colgajos locales para la reconstrucción del labio inferior, el colgajo del músculo buccinador o yugal se considera como una de las principales alternativas, ya que puede lograrse un labio funcional y estético.


The lips are mobile muscle membranous folds, found at the entrance of the oral cavity, whose function is to provide competition for the oral cavity during chewing and rest. Bozzola et al. in 1989, they described the buccal artery as the main pedicle for the Buccinator Muscle. The objective of this work is to demonstrate the effectiveness of the buccinator myomucosal flap for reconstruction of the lower lip in a patient with congenital hemangioma. This is a retrospective longitudinal study, with descriptive results, which was performed in a 32-year-old male patient to cover a lower lip lesion defect secondary to congenital hemangioma using buccinator myomucosal flap reconstruction. The buccinator myomucosal flap or jugal flap is considered one of the best local flaps for the reconstruction of the lower lip whatever the cause, due to its easy dissection and versatility due to the fact that it has a very high survival rate with minimal complications in the postoperative period. Our obtained results agree with the results already published by different authors, reaching the same conclusions; Although there are several techniques with local flaps for the reconstruction of the lower lip, the buccinator or jugal muscle flap is considered one of the main alternatives, since a functional and aesthetic lip can be achieved.


Subject(s)
Humans , Male , Adult , Retrospective Studies , Longitudinal Studies , Reconstructive Surgical Procedures/methods , Myocutaneous Flap/transplantation , Hemangioma/congenital , Lip/surgery
6.
Rev. cuba. angiol. cir. vasc ; 22(1): e206, ene.-abr. 2021. fig
Article in Spanish | LILACS, CUMED | ID: biblio-1251683

ABSTRACT

El hemangioma cavernoso es una neoplasia benigna de los vasos sanguíneos. Este trabajo tuvo como objetivo presentar el caso de un hemangioma cavernoso gigante que fue tratado con propranolol. El diagnóstico se realizó mediante examen físico, dúplex y otros complementarios de interés. Para la decisión de la conducta terapéutica, especialistas de diferentes especialidades evaluaron al paciente: Oncología, Dermatología, Ortopedia, Pediatría y Angiología. Una vez establecido el tratamiento, se realizó un seguimiento durante cuatro semanas y luego mensual. El resultado, después de 22 meses, fue la desaparición del hemangioma. El propranolol en el hemangioma cavernoso gigante debe ser el tratamiento de elección precoz para una evolución satisfactoria y evitar complicaciones(AU)


Cavernous hemangioma is a benign neoplasm of blood vessels. This work aimed at presenting the case of a giant cavernous hemangioma treated with propranolol. The diagnosis was made by physical examination, duplex Doppler sonography, and complementary tests of interest. For deciding the therapeutic approach, the patient was assessed by several specialists from different medical fields, such as oncology, dermatology, orthopedics, pediatrics, and angiology. Once the treatment was established, a follow-up was carried out for four weeks and then monthly. The outcome, after twenty-two months, was the hemangioma disappearance. Propranolol in giant cavernous hemangioma should be the treatment of early choice for a satisfactory evolution and to avoid complications(AU)


Subject(s)
Humans , Male , Female , Blood Vessels , Hemangioma , Hemangioma, Cavernous , Neoplasms , Aftercare
7.
Säo Paulo med. j ; 139(2): 186-189, Mar.-Apr. 2021. tab, graf
Article in English | LILACS | ID: biblio-1181004

ABSTRACT

ABSTRACT CONTEXT: Various skin manifestations have been reported in coronavirus disease. It may be difficult to determine the etiology of these lesions in view of the increased frequency of handwashing during the pandemic, along with occurrences of irritant contact dermatitis and allergic contact dermatitis due to disinfectant use; usage of herbal medicine and supplements to strengthen the immune system; and urticarial or maculopapular drug eruptions due to COVID-19 treatment. The variety of associated skin manifestations seen with COVID-19 makes it challenging to identify virus-specific skin manifestations. Petechiae, purpura, acrocyanosis and necrotic and non-necrotic purpura, which can be considered as manifestations of vascular involvement on the skin, have been reported. CASE REPORT: Here, we report a case of eruptive cherry angiomas, which was thought to have developed due to COVID-19, with a papulovesicular rash on distal extremities that progressed over time to reticular purpura. CONCLUSION: The case presented had a papulovesicular rash at the onset, which evolved to retiform purpura, and eruptive cherry angiomas were observed. It should be kept in mind that dermatological signs may vary in patients with COVID-19.


Subject(s)
Humans , Male , Female , Middle Aged , Purpura/virology , Skin/virology , Skin Diseases, Viral/virology , Exanthema/virology , COVID-19/complications , COVID-19/virology , Hemangioma/virology , Skin/drug effects , Skin/pathology , Treatment Outcome , Skin Diseases, Viral/diagnosis , Skin Diseases, Viral/therapy , COVID-19 Testing , SARS-CoV-2 , COVID-19/drug therapy , COVID-19/therapy
8.
Rev. cuba. cir ; 60(1): e1018, ene.-mar. 2021. graf
Article in Spanish | LILACS, CUMED | ID: biblio-1289380

ABSTRACT

Introducción: Los hemangiomas hepáticos son lesiones no epiteliales que se observan con mucha frecuencia en piezas quirúrgicas resecadas por otras razones. Los hemangiomas que miden 10 cm o más, denominados "hemangiomas gigantes", pueden producir síntomas, como dolor y manifestaciones de un síndrome de reacción inflamatoria y coagulopatía. Los hemangiomas hepáticos son los tumores hepáticos primarios más frecuentes y están presentes en un 0,4-20 por ciento de la población general y es característico que se detecten de manera accidental durante la evaluación de síntomas abdominales inespecíficos. Objetivo: Presentar a una paciente portadora de un hemangioma gigante y características anatómicas peculiares intervenida quirúrgicamente con buenos resultados y evolución excelente. Caso clínico: Paciente de sexo femenino de 24 años de edad, portadora de un Hemangioma hepático gigante en segmento lateral, con variante anatómica vascular que dificultó la embolización y facilitó la cirugía. Se realizó una lobectomía hepática izquierda con una evolución clínica satisfactoria y sin complicaciones. Conclusiones: Las resecciones quirúrgicas de hemangiomas gigantes sintomáticos son una opción terapéutica segura y muy válida ante el fracaso de la embolización(AU)


Introduction: Hepatic hemangiomas are nonepithelial lesions much frequently observed in surgical specimens resected for other reasons. Hemangiomas ten centimeters or more, called "giant hemangiomas," can cause symptoms such as pain, as well as manifestations of an inflammatory reaction syndrome and coagulopathy. Hepatic hemangiomas are the commonest primary hepatic tumors, are present in 0.4-20 percent of the general population, and are typically accidentally detected during the evaluation of nonspecific abdominal symptoms. Objective: To present the case of a patient with a giant hemangioma and unusual anatomical characteristics, who underwent surgery with good outcome and excellent evolution. Clinical case: 24-year-old female patient with a giant hepatic hemangioma in the lateral segment, with a vascular anatomical variant that made embolization difficult and facilitated surgery. A left hepatic lobectomy was performed with satisfactory and uncomplicated clinical evolution. Conclusions: Surgical resections of symptomatic giant hemangiomas are a safe and very valid therapeutic option in case of embolization failure(AU)


Subject(s)
Humans , Female , Young Adult , Hemangioma/epidemiology , Hemangioma, Cavernous/diagnostic imaging , Laparotomy/methods , Liver Neoplasms/pathology
9.
Arch. argent. pediatr ; 119(1): e36-e40, feb. 2021. ilus
Article in English, Spanish | LILACS, BINACIS | ID: biblio-1147255

ABSTRACT

El hemangioma fusocelular es una neoplasia vascular benigna infrecuente. Afecta la dermis y la hipodermis de la parte distal de las extremidades; la afectación de la cabeza y el cuello es muy poco frecuente y nunca se informó compromiso de los senos paranasales. Este es el caso de un lactante de 4 meses con obstrucción nasal desde las 2 semanas debido a un tumor en los senos etmoidales que obstruía las fosas nasales. Se diagnosticó hemangioma fusocelular y se extirpó parcialmente el tumor. A los seis meses de seguimiento, se observó una regresión mínima con lesiones residuales. A los 30 meses, se observó que el tumor residual había desaparecido. El hemangioma fusocelular es infrecuente en cabeza y cuello y, a veces, la presentación no es indicativa del diagnóstico. El examen histopatológico ayuda con el diagnóstico diferencial y el tratamiento. La sensibilización sobre el hemangioma fusocelular podría aumentar los casos informados.


Spindle cell hemangioma (SCH) is a benign unusual vascular neoplasm. It does not have gender predilection and can occur at all ages. The disease affects dermis and subcutis of distal extremities predominantly; head and neck involvement is very rare, paranasal sinus involvement has not been reported before. Herein we present a 4-month-old infant with nasal obstruction since two weeks of age due to a mass in ethmoid sinus obliterating the nasal passage. After the histopathological diagnosis of SCH, the tumor was partially resected. In the sixth month follow-up, there was minimal regression of residual lesions. In the imaging studies performed 30 months after the surgery, the residual mass was found to be disappeared. SCH is not frequent in the head and neck, and presentation of some patients may not suggest the diagnosis. Histopathology is important for differential diagnosis and to orientate treatment. Awareness of SCH may increase the reported cases


Subject(s)
Humans , Male , Infant , Paranasal Sinuses , Head and Neck Neoplasms/surgery , Hemangioma/diagnosis , Nasal Obstruction
10.
Arch. argent. pediatr ; 119(1): e65-e69, feb. 2021. tab, ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1147269

ABSTRACT

El hemangioma hepático es el tumor benigno de hígado más frecuente. Puede ser congénito o infantil, con diferentes evoluciones y complicaciones. La evolución clínica es muy variable, desde pacientes asintomáticos hasta cuadros de gravedad con insuficiencia cardíaca, síndrome de Kasabach-Merritt o síndrome compartimental. El diagnóstico se basa en la historia clínica y los estudios por imágenes, especialmente, la ecografía y el examen doppler en manos experimentadas. Resulta fundamental el diagnóstico diferencial con otras lesiones hepáticas, sobre todo, el hepatoblastoma. En los pacientes sintomáticos, el propranolol surge como primera línea terapéutica con buenos resultados y baja frecuencia de efectos adversos. Se presenta el caso de un recién nacido con hemangioma hepático asociado a síndrome de Kasabach-Merritt, con excelente respuesta y tolerancia al propranolol


Hepatic hemangioma is the most common benign liver tumor. It can be congenital or infantile with different outcomes and complications. The clinical manifestation varies from asymptomatic to severe conditions with heart failure, Kasabach-Merritt syndrome or compartment syndrome. Diagnosis depends on medical history and imaging studies, especially ultrasound and Doppler examination in experienced hands. Differential diagnosis is essential with other hepatic lesions, mainly hepatoblastoma. In symptomatic patients, propranolol emerges as the first line treatment with good results and low frequency of adverse effects. We present the case of a newborn with a hepatic hemangioma and Kasabach-Merritt syndrome with an excellent response and tolerance to propranolol.


Subject(s)
Humans , Male , Infant, Newborn , Kasabach-Merritt Syndrome , Hemangioma/congenital , Prenatal Diagnosis , Propranolol/therapeutic use , Liver Neoplasms
11.
Article in Chinese | WPRIM | ID: wpr-922004

ABSTRACT

OBJECTIVE@#To explore the effect of HNF1A-AS1 on the proliferation, migration and invasion of IL-6-induced hemangioendothelial cells (HemEC) and possible mechanism.@*METHODS@#RT-qPCR was used to detect the expression level of HNF1A-AS1 and miR-363-3p in the tumor tissue and adjacent normal skin tissue from 35 patients with hemangioma. Pearson correlation was used to analyze the correlation between the expression of HNF1A-AS1 and miR-363-3p in tumor tissues. HemEC were isolated and cultured in vitro.Dual luciferase reporter gene experiment was used to study the regulatory effect between HNF1A-AS1 and miR-363-3p. IL-6 was added to HemEC transfected with si-NC, si-HNF1A-AS1, si-HNF1A-AS1 and anti-miR-NC, or si-HNF1A-AS1 and anti-miR-363-3p, respectively. CCK-8 method and clone formation experiment were used to detect cell proliferation in each group. Transwell method was used to detect cell migration and invasion in each group. Western blotting was used to detect the expression of Ki67, MMP-2 and MMP-9 proteins in each group.@*RESULTS@#Compared with normal skin tissues, the expression of IL-6 mRNA in hemangioma tissues was increased (P<0.05), and the expression of IL-6 mRNA in the proliferative phase was lower than that in the degenerative phase (P<0.05). Expression of HNF1A-AS1 in hemangioma tissue was increased (P<0.05), while that of miR-363-3p was decreased (P<0.05), and the two were negatively correlated (r=-0.758, P<0.05). HNF1A-AS1 down-regulated the expression of miR-363-3p in HemEC.IL-6 promoted the expression of HNF1A-AS1, OD value, number of colonies, number of migration and invasion of HemEC cells, and the expression of Ki67, MMP-2 and MMP-9proteins (P<0.05), while reduced the expression of miR-363-3p (P<0.05). Down-regulating si-HNF1A-AS1 reduced the IL-6-induced HemEC cell OD value, colony numbers, migration and invasion and the expression of Ki67, MMP-2 and MMP-9 proteins (P<0.05). Down-regulating miR-363-3p attenuated the inhibitory effect of down-regulating si-HNF1A-AS1 on the proliferation, migration and invasion of HemEC cells induced by IL-6 (P<0.05).@*CONCLUSION@#Expression of HNF1A-AS1 is increased in hemangioma tissues. Down-regulating HNF1A-AS1 may inhibit proliferation, migration and invasion of IL-6-induced hemangioma endothelial cells by targeted up-regulation of miR-363-3p.


Subject(s)
Cell Line, Tumor , Cell Movement , Cell Proliferation , Endothelial Cells , Gene Expression Regulation, Neoplastic , Hemangioma/genetics , Hepatocyte Nuclear Factor 1-alpha/genetics , Humans , Interleukin-6/genetics , MicroRNAs/genetics , RNA, Long Noncoding
12.
Article in English | WPRIM | ID: wpr-887760

ABSTRACT

OBJECTIVES@#This study aimed to explore the short-term clinical efficacy and factors influencing low-dose superficial X-ray for treating infantile maxillofacial hemangioma.@*METHODS@#Retrospective analysis was conducted on 161 cases of infants with maxillofacial hemangioma treated with superficial X-ray in the Laser Center of Dermatology Department of Sichuan Provincial People's Hospital from January 2015 to December 2017. Clinical efficacy was analyzed by comparing the photos before and after treatment. Patients were further divided into groups according to different genders, age at the start of treatment, preterm birth or low birth weight, hemangioma site, longest diameter of hemangioma, and type of hemangioma to analyze whether differences existed in clinical efficacy and therapeutic dose between different groups.@*RESULTS@#Twelve months after the end of treatment, the overall cure rate was 93.8%, and the significant efficiency was 97.5%. The clinical efficacy was related to the age of children at the beginning of treatment and the type of hemangioma (@*CONCLUSIONS@#Low-dose superficial X-ray is safe and effective for the treatment of infantile maxillofacial hemangioma. Age and type of hemangioma at the time of treatment are the factors influencing therapeutic dose and clinical efficacy.


Subject(s)
Child , Female , Hemangioma , Humans , Infant , Infant, Newborn , Male , Pregnancy , Premature Birth , Retrospective Studies , Skin Neoplasms , Treatment Outcome , X-Rays
13.
Article in Spanish | LILACS, BINACIS | ID: biblio-1353936

ABSTRACT

Introducción: Los hemangiomas agresivos constituyen el 1% del total de los hemangiomas vertebrales. Pueden producir dolor, fracturas, deformidad y compromiso neurológico, generalmente de larga evolución. Se han descrito diferentes opciones terapéuticas, pero el manejo óptimo sigue sin estar claro. Comunicamos dos casos de paraparesia aguda secundaria a un hemangioma torácico agresivo, describimos su tratamiento y evolución. Realizamos una revisión narrativa de la bibliografía. Conclusión: Mediante la descompresión y la artrodesis tempranas seguidas de radioterapia, se logró la recuperación neurológica completa y el control de la enfermedad en un seguimiento a mediano plazo. Nivel de Evidencia: IV


Introduction: Aggressive hemangiomas make up 1% of all vertebral hemangiomas. They can produce pain, fractures, deformity and slowly progressive neurological compromise. Different treatment approaches have been described, but optimal management remains unclear. We report two cases of acute paraparesis secondary to aggressive thoracic hemangioma, we describe their treatment and evolution. We carry out a narrative review of the literature on vertebral hemangiomas. Conclusion: Through early decompression and arthrodesis followed by local adjuvant radiotherapy, we obtained complete neurological recovery and disease control in a medium-term follow-up. Level of Evidence: IV


Subject(s)
Adult , Radiotherapy , Spinal Neoplasms , Acute Disease , Paraparesis , Hemangioma
14.
Autops. Case Rep ; 11: e2021270, 2021. tab, graf
Article in English | LILACS | ID: biblio-1249033

ABSTRACT

Background Hemangiomas are benign neoplasms of capillary proliferation that arise from a developmental anomaly where angioblastic mesenchyme fails to form canals. Most hemangiomas arise in the head and neck region, either superficially in the skin or deeper within endocrine organs such as the parotid gland. Parathyroid hemangiomas, however, are extremely rare, with only five cases previously reported in the literature. Case presentation Herein, we present a case of a 68-year-old man with a hemangioma almost completely replacing the right upper parathyroid gland, grossly measuring 1.3 × 1.3 × 1.2 cm and weighing 700 mg, associated with primary hyperparathyroidism. Conclusions Parathyroid gland enlargement due to vascular neoplasms such as hemangiomas can mimic, both clinically and radiographically, hyperplasias and/or adenomas. Surgeons need to be aware of the presence of this entity and should consider it in the differential diagnosis of hyperparathyroidism or parathyroid gland enlargement.


Subject(s)
Humans , Male , Aged , Parathyroid Neoplasms/pathology , Adenoma/pathology , Hemangioma/pathology , Parathyroid Diseases/complications , Diagnosis, Differential
15.
Coluna/Columna ; 19(4): 293-296, Oct.-Dec. 2020. tab, graf
Article in English | LILACS | ID: biblio-1133586

ABSTRACT

ABSTRACT Objectives To present a series of aggressive hemangiomas of the institution, with a review of the management options described in the literature. Methods This is a retrospective survey of aggressive vertebral hemangiomas treated by the service in the last 10 years, with histological confirmation of the diagnosis and a minimum follow-up of 1 year. The case analysis and literature review were conducted with emphasis on treatment options for these injuries. Results Seven cases were found, three with pain and four with severe neurological deficits. Two patients were treated with open decompression, one with open decompression and cementation, one with open decompression and arthrodesis, one with biopsy and cementation, one with percutaneous biopsy, and one with open biopsy followed by decompression surgery. All patients underwent radiotherapy. There was a significant regression of presentation deficits, but one patient developed an irreversible deficit during treatment. There were no recurrences or late complications in the follow-up period. Conclusions Surgical decompression in patients with significant neurological deficit is a point of consensus in the literature. Subtotal resection followed by radiation therapy was effective in treating deficits and controlling pathology. Cases manifesting pain only can be managed with minimally invasive techniques, whether or not they are followed by radiotherapy. Level of evidence IV; Therapeutic study of case series.


RESUMO Objetivo Apresentar a série de hemangiomas agressivos da instituição, com uma revisão das opções de manejo descritas na literatura. Métodos Trata-se de um levantamento retrospectivo dos hemangiomas vertebrais agressivos atendidos pelo serviço nos últimos 10 anos, com confirmação histológica do diagnóstico e seguimento mínimo de um ano. Foi feita análise dos casos e revisão da literatura, com ênfase nas opções de tratamento dessas lesões. Resultados Foram encontrados sete casos, três com dor e quatro com déficits neurológicos graves. Dois pacientes foram tratados com descompressão aberta, um com descompressão aberta e cimentação, um com descompressão aberta e artrodese, um com biópsia e cimentação, um com biópsia percutânea e um com biópsia aberta seguida de cirurgia descompressiva. Todos os pacientes foram submetidos à radioterapia. Houve regressão significativa dos déficits da apresentação, mas uma paciente desenvolveu déficit irreversível durante o tratamento. Não houve recidivas ou complicações tardias no período de acompanhamento. Conclusões A descompressão cirúrgica nos pacientes com déficit neurológico significativo é um ponto de consenso na literatura. A ressecção subtotal seguida de radioterapia foi eficaz no tratamento dos déficits e no controle da patologia. Casos manifestos apenas por dor podem ser manejados com técnicas minimamente invasivas, seguidas ou não de radioterapia. Nível de evidência IV; Estudo terapêutico de série de casos.


RESUMEN Objetivo Presentar la serie de hemangiomas agresivos de la institución, con una revisión de las opciones de manejo descritas en la literatura. Métodos Se trata de un levantamiento retrospectivo de los hemangiomas vertebrales agresivos atendidos por el servicio en los últimos diez años, con confirmación histológica del diagnóstico y un seguimiento mínimo de un año. Fue hecho análisis de los casos y revisión de la literatura, con énfasis en las opciones de tratamiento de esas lesiones. Resultados Fueron encontrados siete casos, tres con dolor y cuatro con déficits neurológicos graves. Dos pacientes fueron tratados con descompresión abierta, uno con descompresión abierta y cementación, uno con descompresión abierta y artrodesis, uno con biopsia y cementación, uno con biopsia percutánea y uno con biopsia abierta seguida de cirugía descompresiva. Todos los pacientes fueron sometidos a radioterapia. Hubo regresión significativa de los déficits de presentación, pero una paciente desarrolló déficit irreversible durante el tratamiento. No hubo recidivas o complicaciones tardías en el período de acompañamiento. Conclusiones La descompresión quirúrgica en los pacientes con déficit neurológico significativo es un punto de consenso en la literatura. La resección subtotal seguida de radioterapia fue eficaz en el tratamiento de los déficits y en el control de la patología. Los casos manifestados solo por dolor pueden ser manejados con técnicas mínimamente invasivas, seguidas o no de radioterapia. Nivel de evidencia IV; Estudio terapéutico de serie de casos.


Subject(s)
Humans , Spinal Neoplasms , Spine , Hemangioma
16.
Pesqui. vet. bras ; 40(8): 614-620, Aug. 2020. tab
Article in English | LILACS, VETINDEX | ID: biblio-1135671

ABSTRACT

ABSTRACT: The present study aimed to describe the occurrence and epidemiological features of skin neoplasms diagnosed in dogs in the metropolitan region of Goiânia, Goiás state, Brazil. Diagnoses from dog biopsies from 2011 to 2016 provided by a private veterinary pathology laboratory were analyzed. The main diagnoses were mast cell tumor, hemangiosarcoma, squamous cell carcinoma, malignant melanoma, and hemangioma. Highest frequency of neoplasms was found in female dogs, dogs aged > 8 years, and purebred dogs, particularly the American Pit Bull Terriers and the Poodles. Most common sites affected by the neoplasms were the limb and the head. Using multiple correspondence analysis, groups of neoplasms were found to be associated with different epidemiological features and the size of the neoplasms was associated with the biological behavior. The results of this study described predispositions and verified the importance of different types of skin neoplasms in dogs in the region being studied.(AU)


O objetivo deste estudo foi determinar a prevalência e as características epidemiológicas das neoplasias cutâneas em cães na região metropolitana de Goiânia, Goiás. Foram analisados os diagnósticos de um laboratório do setor privado de 2011 a 2016. Mastocitoma, hemangiossarcoma, carcinoma de células escamosas, melanoma maligno e hemangioma representaram os principais diagnósticos. A maioria dos casos ocorreram em cães de raças definidas, fêmeas e com idade >8 anos. American Pit Bull Terrier e Poodle foram as raças mais encontradas. As neoplasias acometeram principalmente regiões de membros e cabeça. Pela análise de correspondência múltipla, associou-se os grupos de neoplasias com diferentes características epidemiológicas e o tamanho da neoplasia com o comportamento biológico. A comparação dos resultados com pesquisas prévias possibilitou confirmar predisposições previamente descritas e verificar a importância dos diferentes tipos de neoplasias cutâneas em cães na região estudada.(AU)


Subject(s)
Animals , Male , Female , Dogs , Skin Neoplasms/veterinary , Skin Neoplasms/epidemiology , Carcinoma, Squamous Cell/epidemiology , Mastocytoma/epidemiology , Hemangioma/epidemiology , Hemangiosarcoma/epidemiology , Melanoma/epidemiology , Carcinoma, Squamous Cell/veterinary , Mastocytoma/veterinary , Hemangioma/veterinary , Hemangiosarcoma/veterinary , Melanoma/veterinary
17.
Arq. bras. oftalmol ; 83(4): 338-341, July-Aug. 2020. tab, graf
Article in English | LILACS | ID: biblio-1131607

ABSTRACT

ABSTRACT Infantile hemangioma, the most common benign tumor in infancy, is usually an isolated condition occurring in many different locations in the body. However, large infantile hemangioma may be associated with other systemic malformations, including central nervous system, cerebrovascular, cardiac, and ophthalmology abnormalities, a condition termed PHACE syndrome. In this paper, we describe a case of PHACE syndrome that was presented with the unique association of a large facial infantile hemangioma and morning glory anomaly.


RESUMO O hemangioma infantil é a causa mais comum de tumor benigno na infância e usualmente é uma condição isolada podendo ocorrer em diferentes regiões do corpo. No entanto, hemangiomas infantil extensos podem ser associados com outras malformações sistêmicas incluindo anomalias no sistema nervoso central, cerebrovasculares, cardíacas e oftalmológicas, uma condição denominada síndrome PHACE. Neste trabalho, descrevemos o caso de um paciente com síndrome PHACE que se apresentou com um extenso hemangioma facial e anomalia de "morning glory".


Subject(s)
Humans , Infant , Aortic Coarctation/complications , Abnormalities, Multiple , Eye Abnormalities/complications , Neurocutaneous Syndromes/complications , Eye Neoplasms/complications , Hemangioma , Abnormalities, Multiple/diagnosis , Eye Abnormalities/diagnosis , Eye Neoplasms/diagnosis , Hemangioma/complications , Hemangioma/diagnosis
18.
Prensa méd. argent ; 106(6): 352-356, 20200000.
Article in Spanish | LILACS, BINACIS | ID: biblio-1367043

ABSTRACT

El hemangioma de colon y recto es una entidad poco frecuente. El tipo cavernoso, es aún más raro por lo que existen pocos reportes de esta patología. Afecta mayormente al recto y al sigmoides, y el modo de presentación más común es la proctorragia indolora en el 90% de los casos. Más frecuente en adultos jóvenes. Esta entidad para su diagnóstico requiere alta sospecha y la realización de los estudios pertinentes ya que suele confundírsela con patologías más comunes. En esta revisión se presenta el caso de un paciente masculino de 58 años con un hemangioma cavernoso de colon transverso que se manifestó inicialmente como hematoquecia asociada a astenia. Luego de realizar estudios complementarios, se decide conducta quirúrgica. Se realizó resección de colon transverso con buena evolución postoperatoria. El resultado de anatomía patológica nos informa Hemangioma Cavernoso de colon transverso.


The hemangioma of the colon and rectum is a rare entity. The cavernous type is even more rare, so there are few reports of this pathology. It mainly affects the rectum and the sigmoid, and the most common presentation is painless proctorrhagia in 90% of cases. More frequent in young adults. This entity for its diagnosis requires high suspicion and the realization of the pertinent studies since it is usually confused with more common pathologies. In this review we present the case of a 58-year-old male patient with a cavernous hemangioma of the transverse colon that initially manifested as hematochezia associated with asthenia. After performing complementary studies, surgical behavior is decided. Transverse colon resection was performed with good postoperative evolution. The result of pathological anatomy informs us Cavernous hemangioma of transverse colon


Subject(s)
Humans , Male , Middle Aged , Colectomy , Colon, Transverse/surgery , Hemangioma/pathology , Hemangioma, Cavernous/pathology
19.
Rev. bras. oftalmol ; 79(4): 273-275, July-Aug. 2020. graf
Article in Portuguese | LILACS | ID: biblio-1137975

ABSTRACT

Resumo O hemangioma de coroide é um tumor benigno relativamente raro, que se apresenta de forma circunscrita ou difusa, sendo esta última normalmente associada à Síndrome de Sturge-Weber. Os tumores circunscritos manifestam-se de forma insidiosa, com o diagnóstico realizado comumente após o aparecimento de sintomas secundários. Apresentam como diagnóstico diferencial lesões graves e potencialmente letais, como melanoma de coroide e doença metastática. Neste relato descrevemos o caso de um hemangioma intraocular nodular avançado associado a descolamento hemorrágico da retina, evidenciando o desafio do diagnóstico diferencial devido às semelhanças clínicas e radiológicas compartilhadas pelos tumores.


Abstract Choroidal hemangioma is a fairly rare benign vascular tumor that can manifest in either circumscribed or diffuse type; the latter one is usually related to Sturge-Weber Syndrome. The circumscribed tumors have an insidious presentation and diagnosis is commonly made after the onset of secondary symptoms. Serious and potentially lethal lesions, such as choroidal melanoma and metastatic disease, may represent a differential diagnosis. In this report, we describe an advanced case of nodular hemangioma associated with hemorrhagic retinal detachment. This case highlights the challenge of differential diagnosis in intraocular tumors, due to their similar clinical and radiologic features.


Subject(s)
Humans , Male , Adult , Retinal Detachment/diagnosis , Glaucoma, Neovascular/diagnosis , Choroid Neoplasms/diagnosis , Choroid Neoplasms/pathology , Hemangioma/diagnosis , Hemangioma/pathology , Eye Enucleation , Diagnosis, Differential
20.
Rev. bras. cir. plást ; 35(2): 254-257, apr.-jun. 2020. ilus
Article in English, Portuguese | LILACS | ID: biblio-1103842

ABSTRACT

Hemangioma infantil (HI) é o tumor vascular mais comum e a neoplasia benigna mais frequente da infância, com maior incidência no sexo feminino e na população branca. Quase 60% dos casos ocorrem em cabeça e pescoço, sendo o tratamento ativo durante a fase proliferativa mais frequentemente indicado, em decorrência dos possíveis problemas funcionais e do potencial desfigurante. Relatamos um caso de paciente com hemangioma infantil involuído de ponta nasal e lábio superior, tratado de forma expectante durante a infância, submetida à correção da deformidade residual com técnicas de rinoplastia, associado à zetaplastia e lipoenxertia do lábio superior com bom resultado e satisfação do paciente.


Infantile hemangioma (IH) is the most common vascular tumor and the most frequent benign neoplasm in childhood, with the highest incidence in females and the white population. Almost 60% of cases occur in the head and neck, and active treatment during the proliferative phase is the most frequently indicated, due to possible functional problems and disfiguring potential. We report a case of a patient with involute infantile hemangioma of the nasal tip and upper lip, treated expectantly during childhood, submitted to residual deformity correction with rhinoplasty techniques, associated with zetaplasty and upper lip grafting with good results and patient satisfaction.


Subject(s)
Humans , Female , Adult , History, 21st Century , Rhinoplasty , Wounds and Injuries , Case Reports , Nose , Nose Diseases , Vascular Neoplasms , Hemangioma , Lip , Rhinoplasty/adverse effects , Rhinoplasty/methods , Wounds and Injuries/surgery , Nose/surgery , Nose/pathology , Nose Diseases/surgery , Nose Diseases/pathology , Vascular Neoplasms/surgery , Vascular Neoplasms/pathology , Hemangioma/surgery , Hemangioma/pathology , Lip/surgery , Lip/pathology
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