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1.
Notas enferm. (Córdoba) ; 21(38): 34-42, nov. 2021.
Article in Spanish | LILACS, BDENF, BINACIS, UNISALUD | ID: biblio-1348586

ABSTRACT

Si bien el uso rtPA está indicado para diversas patologías como el tratamiento trombolítico en los infartos agudos de miocardio, el tromboembolismo pulmonar agudo con inestabilidad hemodinamica y el tratamiento trombolítico del accidente cerebrovascular isquémico agudo conforme a la disposición DI­2018-495-APN-ANMAT#MSYDS el uso del mismo en Argentina y conforme a consenso (consenso sobre accidente cerebrovascular isquémico agudo). La administración oportuna del rtPA, a pacientes apropiadamente seleccionados constituye el principal tratamiento de forma temprana en el ACV (1-8). Por lo que el rol que cumple enfermería es fundamental en la valoración de riesgos previa a la administración, preparación, administración del fármaco y valoración continua post administración del mismo[AU]


Although the use of rtPA is indicated for various pathologies such as thrombolytic treatment in acute myocardial infarctions, acute pulmonary thromboembolism with hemodynamic instability, and thrombolytic treatment of acute ischemic stroke according to the DI-2018-495-APN-ANMAT provision. #MSYDS the use of thesame in Argentina and accordingtoconsensus (consensus on accident cerebrovascular ischemico acute). Timely administration of rtPAto appropriately selected patients constitutes the main treat mentearly in stroke (1,8). Therefore, the role play edby nursingis fundamental in the risk ass essment prior to the administration, preparation, administration of the drug, and continuous post-administration assessment[AU]


Embora o uso de rtPA seja indicado para várias patologias, como tratamento trombolítico em infartos agudos do miocárdio, tromboembolismo pulmonar agudo com instabilidade hemodinâmica e tratamento trombolítico de acidente vascular cerebral isquêmico agudo de acordo com a disposição DI- 2018-495-APN-ANMAT. #MSYDS a uso do mesmona Argentina e de acordocom o consenso (consensus on accident cerebrovascular ischemico agute). A administração oportuna de rtPA a pacientes adequadamente selecionados constitui o principal tratamento no início do AVC (1,8). Por tanto, o papel da enfermagem é fundamental na avaliação do risco antes da administração, preparo, administração do medicamento e avaliação pós-administração contínua[AU]


Subject(s)
Humans , Plasminogen , Plasminogen/administration & dosage , Stroke , Ischemic Stroke , Myocardial Infarction , Nursing Care , Pulmonary Embolism , Hemodynamics
2.
Rev. colomb. anestesiol ; 49(3): e601, July-Sept. 2021. tab, graf
Article in English | LILACS, COLNAL | ID: biblio-1280184

ABSTRACT

Abstract The new coronavirus 2019-nCov or SARS-Cov-2 is responsible for the most important pandemic in the 21st century: the coronavirus disease (COVID-19). The 2019-nCov infection elicits a hyper-coagulable state, conditioning a worse outcome in these patients. The pathophysiology of the exaggerated coagulation activation in these patients is still unknown, and probably involves several mechanisms, different from those involved in sepsis-associated coagulopathy. This article discusses the case of a patient with no remarkable medical history, who after 7 days of fever, diarrhea and epigastric pain was diagnosed with COVID-19 bilateral pneumonia, further aggravated by severe Acute Respiratory Distress Syndrome. In this context, the patient experienced a massive acute pulmonary thromboembolism accompanied by an acute thrombus in the heart's right ventricle, leading to hemodynamic instability. For the first time in our center in these patients, systemic fibrinolysis was successfully performed, with resolution of the intracavitary thrombus and the acute hemodynamic shock.


Resumen El nuevo coronavirus 2019-nCov o SARS-Cov-2 es responsable de la pandemia más importante del siglo XXI: la enfermedad del coronavirus (COVID-19). La infección por 2019-nCov produce un estado de hipercoagulabilidad, que promueve peores desenlaces en estos pacientes. La fisiopatología de la exagerada activación de la coagulación en estos pacientes aún se desconoce y posiblemente involucre varios mecanismos, diferentes a los participan en la coagulopatía asociada a sepsis. El presente artículo presenta el caso de un paciente sin antecedentes médicos y quien luego de 7 días de fiebre, diarrea y dolor epigástrico, fue diagnosticado con neumonía bilateral por COVID-19, agravada por la presencia de Síndrome de Dificultad Respiratoria Aguda. En este contexto, el paciente desarrolla un tromboembolismo pulmonar agudo masivo, acompañado de un trombo agudo en el ventrículo derecho, produciéndole inestabilidad hemodinámica. Por primera vez en nuestro centro, se realizó exitosamente una fibrinólisis sistémica, con resolución del trombo intracavitario y del shock hemodinámico agudo.


Subject(s)
Humans , Male , Adult , Pulmonary Embolism , Thrombosis , Blood Coagulation , Pandemics , Fibrinolysis , COVID-19 , Respiratory Distress Syndrome, Newborn , Coronavirus , SARS-CoV-2 , Heart Ventricles , Hemodynamics , Infections
3.
Rev. colomb. anestesiol ; 49(2): e800, Apr.-June 2021. graf
Article in English | LILACS, COLNAL | ID: biblio-1251506

ABSTRACT

Patients with severe COVID-19 infection frequently require to be in prone position. 1 Furthermore, these patients with mechanical ventilation need additional vasopressor support (95.4 % vs. 1.5 %) and exhibit a higher risk of developing atrial arrhythmias (17.7 % vs. 1.9 %). 2 A study conducted in Wuhan, China, reported that 17.9 % of the patients experienced intrahospital cardiac arrest; the arrest rhythms were asystole (89.7 %), pulseless electrical activity (4.4 %) and defibrillatable rhythms (5.9 %). 3 In order to reduce the hemodynamic effects secondary to changes in position 4 cardiopulmonary resuscitation (CPR) maneuvers in prone position are recommended (inverted CPR) 5; this technique was described in 1989 by McNeil, and has proven to be successful 6,7 doing the inverse precordial compressions at the usual rate and amplitude. 8 86 % of the patients have the largest left ventricular area localized between 0 and 2 vertebral segments below the line that crosses the two inferior angles of the scapulae. In this location, the maneuver may be done as shown in Figure 1


Los pacientes con infección grave por COVID-19 requieren con frecuencia estar en posición prona. 1 Además, estos pacientes con ventilación mecánica necesitan apoyo vasopresor adicional (95,4 % frente a 1,5 %) y presentan un mayor riesgo de desarrollar arritmias auriculares (17,7 % frente a 1,9 %). 2 Un estudio realizado en Wuhan, China, informó de que el 17,9% de los pacientes experimentaron una parada cardiaca intrahospitalaria; los ritmos de parada fueron asistolia (89,7%), actividad eléctrica sin pulso (4,4%) y ritmos desfibrilables (5,9%). 3 Para reducir los efectos hemodinámicos secundarios a los cambios de posición 4 se recomiendan las maniobras de reanimación cardiopulmonar (RCP) en decúbito prono (RCP invertida) 5; esta técnica fue descrita en 1989 por McNeil, y ha demostrado ser exitosa 6,7 realizando las compresiones precordiales inversas a la frecuencia y amplitud habituales. 8 El 86% de los pacientes tienen la mayor área ventricular izquierda localizada entre 0 y 2 segmentos vertebrales por debajo de la línea que cruza los dos ángulos inferiores de las escápulas. En esta localización, la maniobra puede realizarse como se muestra en la figura 1


Subject(s)
Humans , Respiration, Artificial , Prone Position , Cardiopulmonary Resuscitation , COVID-19 , Pulse , Risk , Selection of the Waste Treatment Site , Heart Arrest , Hemodynamics , Infections
4.
Vive (El Alto) ; 4(10): 26-34, abr. 2021. tab.
Article in Spanish | LILACS | ID: biblio-1292649

ABSTRACT

La insuficiencia renal crónica es una complicación de varias enfermedades, uno de los tratamientos sustitutivos es la hemodiálisis, tratamiento donde el paciente puede presentar algunas complicaciones durante la realización de este proceso, por ende existe una gran preocupación en la alta tasa de incidencia de usuarios con enfermedades renales crónica y el cuidado que estos requieren en las unidades de hemodiálisis durante la sesión. OBJETIVO: determinar la inestabilidad hemodinámica durante el proceso intradialítica en usuarios con insuficiencia renal crónica sometidos a hemodiálisis. MÉTODO: fue un estudio descriptivo, se utilizó como técnica la observación directa y encuesta, el instrumento utilizado fue la hoja de recolección de datos sobre complicaciones en usuarios con hemodiálisis, guía de observación aplicada y el cuestionario. RESULTADOS: un 56% del sexo masculino, el 48% eran mayores de 61 años de edad, un 88% con catéter vascular; el 36% por causa glomerulonefritis, 41% con comorbilidad de hipertensión, 33% con diabetes mellitus, 67% con hipotensión intradialítica e hipertensión 33%. CONCLUSIONES: utilizando la metodología disciplinar y el lenguajes estandarizados de la taxonomía NANDA, NIC, NOC, esto facilitara la recolección sistemática de información, la toma de decisiones sobre la efectividad del cuidado enfermero, para elevar la calidad de atención y disminuir las complicaciones como la hipotensión en usuarios sometidos a hemodiálisis, para garantizar la seguridad del usuario. (AU)


Chronic kidney failure is a complication of several diseases, one of the substitute treatments is hemodialysis, a treatment where the patient may present some complications during this process, and therefore there is great concern in the high incidence rate of users with chronic kidney diseases and the care they require in the hemodialysis units during the session. OBJECTIVE: to determine the hemodynamic instability during the intradialytic process in users with chronic renal failure undergoing hemodialysis. METHOD: it was a descriptive study, direct observation and survey were used as a technique, and the instrument used was the data collection sheet on complications in users with hemodialysis, the observation guide applied and the questionnaire. RESULTS: 56% were males, 48% were older than 61 years of age, and 88% had a vascular catheter; 36% due to glomerulonephritis, 41% with comorbidity of hypertension, 33% with diabetes mellitus, 67% with intradialytic hypotension and 33% hypertension. CONCLUSIONS: using the disciplinary methodology and the standardized languages of the NANDA, NIC, NOC taxonomy, this will facilitate the systematic collection of information, decision-making on the effectiveness of nursing care, to increase the quality of care and reduce complications such as hypotension in patients. Users undergoing hemodialysis, to ensure user safety.(AU)


A insuficiência renal crônica é uma complicação de várias doenças, um dos tratamentos substitutos é a hemodiálise, um tratamento onde o paciente pode apresentar algumas complicações durante este processo, portanto existe grande preocupação na alta incidência de usuários com doenças renais crônicas e os cuidados eles exigem nas unidades de hemodiálise durante a sessão. OBJETIVO: determinar a instabilidade hemodinâmica durante o processo intradialítico em usuários com insuficiência renal crônica em hemodiálise. MÉTODO: foi um estudo descritivo, utilizou-se como técnica a observação direta e o survey, o instrumento utilizado foi a ficha de coleta de dados sobre complicações em usuários em hemodiálise, o guia de observação aplicado e o questionário. RESULTADOS: 56% eram homens, 48% tinham mais de 61 anos de idade, 88% possuíam cateter vascular; 36% devido a glomerulonefrite, 41% com comorbidade de hipertensão, 33% com diabetes mellitus, 67% com hipotensão intradialítica e 33% com hipertensão. CONCLUSÕES: usando a metodologia disciplinar e as linguagens padronizadas da taxonomia NANDA, NIC, NOC, isso facilitará a coleta sistemática de informações, a tomada de decisão sobre a eficácia da assistência de enfermagem, para aumentar a qualidade da assistência e reduzir complicações como hipotensão em pacientes usuários em hemodiálise, para garantir a segurança do usuário.(AU)


Subject(s)
Renal Insufficiency , Hemodynamics , Data Collection , Renal Dialysis
5.
Arq. bras. med. vet. zootec. (Online) ; 73(2): 383-394, Mar.-Apr. 2021. graf, ilus
Article in English | ID: biblio-1248923

ABSTRACT

This study used B-mode and Doppler ultrasonography to characterize the abdominal structures of healthy peccaries raised in captivity. Fifteen peccaries were used for this study. The urinary vesicle appeared as an ovoid structure, located in the abdominal and pelvic transition, with a hyperechogenic, thin, smooth, and regular wall. The kidneys presented retroperitoneal topography and had similar sizes. The kidney/aorta ratio had an average value of 10.53±15cm (right) and 10.23±0.12 (left). The right adrenal gland had a length of 1.93±0.34cm and diameter of 0.56±0.16cm. The left adrenal gland had a length of 1.85±0.42cm and diameter of 0.52±0.11cm. The spleen had a diameter of 1.13±0.18cm. The hepatic vein demonstrated polyphasic flow in pulsed Doppler, with two retrograde peaks and an anterograde peak with a flow velocity of 25.7±0.83cm/s. The abdominal aorta had a diameter of 0.58±0.05cm and a flow velocity of 115.17±5.32cm/s. The morphological and hemodynamic study of the abdominal structures of the peccary, observed through B-mode and Doppler ultrasonography, aided in identifying the size, shape, position, echogenicity, and echotexture of the abdominal organs and in making inferences about the normal parameters for these structures in this species.(AU)


Este estudo teve como objetivo utilizar as ultrassonografias de modo-B e Doppler para caracterizar as estruturas abdominais de um cateto sadio criado em cativeiro. Quinze catetos foram utilizados para este estudo. A vesícula urinária apareceu como uma estrutura ovoide, localizada na transição entre as partes abdominal e pélvica, com uma parede hiperecogênica, fina, lisa e regular. Os rins apresentaram topografia retroperitoneal e tamanhos semelhantes. A relação rim/aorta teve um valor médio de 10,53 ± 15cm (direita) e 10,23 ± 0,12cm (esquerda). A glândula adrenal direita tinha um comprimento de 1,93 ± 0,34cm e um diâmetro de 0,56 ± 0,16cm. A glândula suprarrenal esquerda tinha um comprimento de 1,85 ± 0,42cm e um diâmetro de 0,52 ± 0,11cm. O baço tinha um diâmetro de 1,13 ± 0,18cm. A veia hepática demonstrou fluxo polifásico no Doppler pulsátil, com dois picos retrógrados e um pico anterógrado com velocidade de fluxo de 25,7±0,83cm/s. A aorta abdominal tinha um diâmetro de 0,58 ± 0,05cm e uma velocidade de fluxo de 115,17±5,32cm/s. Os estudos morfológico e hemodinâmico das estruturas abdominais do queixada, observadas por meio das ultrassonografias modo-B e Doppler, auxiliaram na identificação do tamanho, da forma, da posição, da ecogenicidade e da ecotextura dos órgãos abdominais e na realização de inferências sobre os parâmetros de normalidade para as estruturas nas espécies.(AU)


Subject(s)
Animals , Artiodactyla/anatomy & histology , Abdomen/diagnostic imaging , Hemodynamics , Echocardiography, Doppler/veterinary , Ultrasonography, Doppler/veterinary
6.
Rev. bras. cir. cardiovasc ; 36(1): 10-17, Jan.-Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1155793

ABSTRACT

Abstract Introduction: There are scarce data comparing different mechanical valves in the aortic position. The objective of this study was to compare the early hemodynamic changes after aortic valve replacement between ATS, Bicarbon, and On-X mechanical valves. Methods: We included 99 patients who underwent aortic valve replacement with mechanical valves between 2017 and 2019. Three types of mechanical valves were used, On-X valve (n=45), ATS AP360 (n=32), and Bicarbon (n=22). The mean prosthetic valve gradient was measured postoperatively and after six months. Results: Preoperative data were comparable between groups, and there were no differences in preoperative echocardiographic data. Pre-discharge echocardiography showed no difference between groups in the ejection fraction (P=0.748), end-systolic (P=0.764) and end-diastolic (P=0.723) diameters, left ventricular mass index (P=0.348), aortic prosthetic mean pressure gradient (P=0.454), and indexed aortic prosthetic orifice area (P=0.576). There was no difference in the postoperative aortic prosthetic mean pressure gradient between groups when stratified by valve size. The changes in the aortic prosthetic mean pressure gradient of the intraoperative period, at pre-discharge, and at six months were comparable between the three prostheses (P=0.08). Multivariable regression analysis revealed that female gender (beta coefficient -0.242, P=0.027), body surface area (beta coefficient 0.334, P<0.001), and aortic prosthetic size (beta coefficient -0.547, P<0.001), but not the prosthesis type, were independent predictors of postoperative aortic prosthetic mean pressure gradient. Conclusion: The three bileaflet mechanical aortic prostheses (On-X, Bicarbon, and ATS) provide satisfactory early hemodynamics, which are comparable between the three valve types and among different valve sizes.


Subject(s)
Humans , Male , Female , Aortic Valve Stenosis/surgery , Heart Valve Prosthesis , Aortic Valve/surgery , Aortic Valve/diagnostic imaging , Prosthesis Design , Echocardiography , Echocardiography, Doppler , Hemodynamics
7.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 91-98, Jan.-Feb. 2021. tab
Article in English | ID: biblio-1153050

ABSTRACT

The metabolic peculiarities of felines favor an intoxication. Fifty healthy female cats were divided into five groups: PG (placebo group), G2 (cefazolin), G3 (ceftriaxone), G4 (enrofloxacin) and G5 (ampicillin) were used. The parameters evaluated were: total expired carbon dioxide (ETCO2), oxygen saturation in hemoglobin (SpO2), heart rate (HR), respiratory rate (RR), body temperature (BT), systolic, mean and diastolic blood pressure (SBP, mBP and DBP) by invasive method, at T0, 5 (T5), 10 (T10), 15 (T15), 20 (T20), 25 (T25) and 30 (T30) minutes after administration of the treatments. HR presented reduction in G2 compared to PG at all times, except T20, and in G4, T25 and T30 were lower than the T0 values (P<0.05). BT showed increase in the G3 at T0 and T5 and all groups showed reduction in the values of BT relative to T0 (P<0.05). ETCO2 increased in G2 and G5 at all times compared to PG (P<0.05) and there were no differences among the times within each group. It was concluded that ceftriaxone is safer for the prophylactic antimicrobial use in cats, however the other antimicrobials are also indicated, because all the parameters, in all groups, basically did not change over the study and when this occurs it remains in reference interval.(AU)


As peculiaridades metabólicas dos felinos favorecem quadro de intoxicação. Foram utilizadas 50 gatas saudáveis, que foram divididas em cinco grupos: GP (grupo placebo), G2 (grupo cefazolina), G3 (grupo ceftriaxona), G4 (grupo enrofloxacina) e G5 (grupo ampicilina). Os seguintes parâmetros foram avaliados: dióxido de carbono expirado (ETCO2), saturação de oxigênio na hemoglobina (SpO2), frequência cardíaca (FC), frequência respiratória (FR), temperatura corporal (T°C), pressão arterial sistólica,média e diastólica (PAS, PAM e PAD), pelo método invasivo, em 0 (T0), 5 (T5), 10 (T10), 15 (T15), 20 (T20), 25 (T25) e 30 (T30) minutos após a administração dos tratamentos. A FC apresentou redução no G2 em relação ao GP em todos os momentos, exceto no T20, e, no G4, o T25 e o T30 foram inferiores aos valores do T0 (P<0,05). A T°C apresentou aumento no G3 no T0 e no T5, e todos os grupos apresentaram redução nos valores da T°C em relação ao T0 (P<0,05). O ETCO2 apresentou aumento no G2 e no G5, em todos os momentos, em relação ao GP (P<0,05). Concluiu-se que a ceftriaxona é mais segura para uso profilático em gatos, entretanto os outros antibióticos também são recomendados, pois todos os parâmetros praticamente não se modificaram e, quando alterados, mantiveram-se dentro dos padrões de referência.(AU)


Subject(s)
Animals , Cats , Ceftriaxone/administration & dosage , Respiratory Rate/drug effects , Heart Rate/drug effects , Anti-Infective Agents/administration & dosage , Anti-Infective Agents/adverse effects , Hemodynamics , Anesthesia, Intravenous/veterinary
8.
Rev. bras. med. esporte ; 27(1): 94-97, Jan.-Mar. 2021. tab
Article in English | LILACS | ID: biblio-1156103

ABSTRACT

ABSTRACT Introduction It is known that strength training brings improvements in health and sports performance by causing muscle hypertrophy and increased strength, as well as modifying some hemodynamic and physiological factors. Several strength training methodologies have been developed, one of which is vascular occlusion. There are few studies with large muscle groups due to poor adherence to the training style and the fact that vascular occlusion of large muscle groups is more difficult. Objective To verify and compare the hemodynamic effects of exercise with and without vascular occlusion in different muscle groups. Methods Quantitative crossover study, with cross-sectional and field procedures. The sample consisted of 10 physically active healthy male and female subjects between 18 and 30 years of age. With the cross-over design, all the volunteers participated in 3 groups: intervention with vascular occlusion, intervention without vascular occlusion and the control group. Results Overall, lactate and cholesterol remained elevated after 15 minutes of recovery and blood glucose and blood pressure did not vary among the groups. Conclusion Vascular occlusion training is an effective method for manipulating hemodynamic variables. Evidence level II; Clinical study.


RESUMO Introdução Sabe-se que o treino de força traz melhorias para a saúde e o desempenho esportivo, por ocasionar hipertrofia muscular e aumento de força, além de modificar alguns fatores hemodinâmicos e fisiológicos. Foram desenvolvidos vários métodos de treinamento de força, entre eles, a oclusão vascular. Porém, existem poucos estudos com grandes grupamentos musculares, devido à pouca adesão ao estilo de treino e ao fato de a oclusão vascular de grandes grupos musculares ser mais difícil. Objetivo Verificar e comparar os efeitos hemodinâmicos do exercício com e sem oclusão vascular em diferentes grupamentos musculares. Métodos Estudo quantitativo, cruzado, com procedimentos transversais e de campo. A amostra foi composta por 10 indivíduos saudáveis e fisicamente ativos do sexo masculino e feminino, na faixa etária de 18 a 30 anos. Com o desenho cruzado, todos os voluntários participaram de 3 grupos: intervenção com oclusão vascular, intervenção sem oclusão vascular e grupo controle. Resultados De forma geral, entre grupos, o lactato e o colesterol se mantiveram elevados depois de 15 minutos de recuperação, a glicemia e as pressões arteriais não variaram. Conclusão O treinamento com oclusão vascular é um método eficaz para manipular as variáveis hemodinâmicas. Nível de evidência II; Estudo clínico.


RESUMEN Introducción Se sabe que el entrenamiento de fuerza trae mejoras para la salud y el desempeño deportivo, por causar hipertrofia muscular y aumento de fuerza, además de modificar algunos factores hemodinámicos y fisiológicos. Fueron desarrollados varios métodos de entrenamiento de fuerza, entre ellos, la oclusión vascular. Sin embargo, existen pocos estudios con grandes grupos musculares, debido a la poca adhesión al estilo de entrenamiento y al hecho de que la oclusión vascular de grandes grupos musculares grandes es más difícil. Objetivo Verificar y comparar los efectos hemodinámicos del ejercicio con y sin oclusión vascular en diferentes grupos musculares. Métodos Estudio cuantitativo, cruzado, con procedimientos transversales y de campo. La muestra fue compuesta por 10 individuos saludables y físicamente activos del sexo masculino y femenino, en el grupo de edad de 18 a 30 años. Con el diseño cruzado, todos los voluntarios participaron en 3 grupos: intervención con oclusión vascular, intervención sin oclusión vascular y grupo control. Resultados De forma general, entre los grupos, el lactato y el colesterol se mantuvieron elevados después de 15 minutos de recuperación, la glucemia y las presiones arteriales no variaron. Conclusión El entrenamiento de oclusión vascular es un método eficaz para manipular las variables hemodinámicas. Nivel de evidencia II; Estudio clínico.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Physical Endurance/physiology , Blood Circulation , Exercise/physiology , Muscles/blood supply , Blood Glucose/analysis , Restraint, Physical , Cholesterol/blood , Cross-Sectional Studies , Lactic Acid/blood , Hemodynamics
9.
Article in Chinese | WPRIM | ID: wpr-879856

ABSTRACT

OBJECTIVE@#To compare the effect of delayed cord clamping (DCC) versus umbilical cord milking (UCM) on cerebral blood flow in preterm infants.@*METHODS@#This was a single-center, prospective, double-blind, randomized controlled trial. A total of 46 preterm infants, with a gestational age of 30-33@*RESULTS@#A total of 21 preterm infants in the DCC group and 23 in the UCM group were included in the statistical analysis. There was no significant difference in PSV, EDV, and RI between the two groups at all time points after birth (@*CONCLUSIONS@#DCC and UCM have a similar effect on cerebral hemodynamics in preterm infants with a gestational age of 30-33


Subject(s)
Constriction , Hemodynamics , Humans , Infant , Infant, Newborn , Infant, Premature , Prospective Studies , Umbilical Cord
10.
Article in Chinese | WPRIM | ID: wpr-879822

ABSTRACT

OBJECTIVE@#To study the changes in hemodynamics during the induction stage of systemic mild hypothermia therapy in neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE).@*METHODS@#A total of 21 neonates with HIE who underwent systemic mild hypothermia therapy in the Department of Neonatology, Dongguan Children's Hospital Affiliated to Guangdong Medical University, from July 2017 to April 2020 were enrolled. The rectal temperature of the neonates was lowered to 34℃ after 1-2 hours of induction and maintained at this level for 72 hours using a hypothermia blanket. The impedance method was used for noninvasive hemodynamic monitoring, and the changes in heart rate (HR), mean arterial pressure (MAP), stroke volume (SV), cardiac output (CO), cardiac index (CI), and total peripheral resistance (TPR) from the start of hypothermia induction to the achievement of target rectal temperature (34℃). Blood lactic acid (LAC) and resistance index (RI) of the middle cerebral artery were recorded simultaneously.@*RESULTS@#The 21 neonates with HIE had a mean gestational age of (39.6±1.1) weeks, a mean birth weight of (3 439±517) g, and a mean 5-minute Apgar score of 6.8±2.0. From the start of hypothermia induction to the achievement of target rectal temperature (34℃), there were significant reductions in HR, CO, and CI (@*CONCLUSIONS@#The systemic mild hypothermia therapy may have a significant impact on hemodynamics in neonates with moderate to severe HIE, and continuous hemodynamic monitoring is required during the treatment.


Subject(s)
Cardiac Output , Child , Hemodynamics , Humans , Hypothermia , Hypoxia-Ischemia, Brain/therapy , Infant , Infant, Newborn , Vascular Resistance
11.
Article in Chinese | WPRIM | ID: wpr-877558

ABSTRACT

OBJECTIVE@#To observe the therapeutic effect between acupuncture combined with medication and simple medication on migraine and cerebral hemodynamics.@*METHODS@#A total of 120 patients with migraine were randomized into an acupuncture plus medication group (60 cases, 3 cases dropped off) and a medication group (60 cases, 6 cases dropped off). In the medication group, flunarizine hydrochloride capsule was given orally before sleep, 10 mg a day. On the basis of the treatment in the medication group, acupuncture was applied at Sizhukong (TE 23), Shuaigu (GB 8), Taiyang (EX-HN 5), Fengchi (GB 20) and etc. in the acupuncture plus medication group, 30 min each time, once a day. Treatment for 4 weeks was required in both groups. Before and after treatment, the visual analogue scale (VAS) score, indexes of cerebral hemodynamic [blood flow velocity of anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA), vertebral artery (VA) and basilar artery (BA)] and total TCM syndrome score were observed, and the clinical therapeutic effect and the incidence of the adverse events were evaluated in both groups.@*RESULTS@#Compared before treatment, the VAS scores, the blood flow velocity of ACA, MCA, PCA, VA, BA and the total TCM syndrome scores were decreased in both groups (@*CONCLUSION@#Acupuncture combined with flunarizine hydrochloride capsule can effectively relieve the pain in patients with migraine, reduce the cerebral blood flow velocity, the efficacy is superior to simple flunarizine hydrochloride capsule.


Subject(s)
Acupuncture Points , Acupuncture Therapy , Hemodynamics , Humans , Migraine Disorders/therapy , Pain , Treatment Outcome
12.
Rev. latinoam. enferm. (Online) ; 29: e3415, 2021. tab
Article in English | LILACS, BDENF | ID: biblio-1280459

ABSTRACT

Abstract Objective: to evaluate the complications of percutaneous renal biopsy based on outcomes and clinical indicators of the Nursing Outcomes Classification. Method: a prospective longitudinal study. The sample consisted of 13 patients submitted to percutaneous renal biopsy, with 65 evaluations. The patients were evaluated in five moments in the 24 hours after the procedure, using an instrument developed by the researchers based on five outcomes (Blood coagulation, Circulation status, Blood loss severity, Pain level, Comfort status: Physical) and 11 indicators. The Generalized Estimation Equation Test was used to compare the scores of the indicators. The project was approved by the institutional ethics committee. Results: in the 65 evaluations, a statistically significant difference was identified in the reduction of the scores of the following nursing outcomes: Blood coagulation, "hematuria" indicator; Circulation status, in the "systolic blood pressure and diastolic blood pressure" indicators and Comfort status: physical, in the "physical well-being" indicator. Conclusion: the evaluated patients did not show major complications. The clinical indicators signaled changes in circulation status, with reduced blood pressure, as well as in blood clotting observed by hematuria, but without hemodynamic instability. The comfort status was affected by the rest time after the procedure.


Objetivo: evaluar las complicaciones de la biopsia renal percutánea con base en los resultados e indicadores clínicos de la Nursing Outcomes Classification. Método: estudio longitudinal prospectivo. La muestra fue de 13 pacientes a los que se les realizó biopsia renal percutánea, con 65 evaluaciones. Los pacientes fueron evaluados en cinco momentos en las 24 horas posteriores al procedimiento, utilizando un instrumento desarrollado por los investigadores con base en cinco resultados (Coagulación sanguínea, Estado circulatorio, Severidad de la pérdida de sangre, Nivel de dolor, Estado de comodidad: física) y 11 indicadores. Se utilizó la Prueba de Ecuación de Estimación Generalizada para comparar los puntajes de los indicadores. El proyecto fue aprobado por el comité ético institucional. Resultados: en las 65 evaluaciones, se identificó una diferencia estadísticamente significativa en la reducción de los puntajes de los resultados de enfermería Coagulación sanguínea, indicador "hematuria"; Estado circulatorio, en los indicadores "presión arterial sistólica y presión arterial diastólica" y en el Estado de comodidad: física, en el indicador de "bienestar físico". Conclusión: los pacientes evaluados no presentaron mayores complicaciones. Los indicadores clínicos apuntaban a cambios en el estado circulatorio, con reducción presión arterial, así como en la coagulación sanguínea verificada por hematuria, pero sin inestabilidad hemodinámica. El estado de comodidad se vio afectado por el tiempo de descanso posterior al procedimiento.


Resumo Objetivo: avaliar as complicações da biópsia renal percutânea com base nos resultados e indicadores clínicos da Nursing Outcomes Classification. Método: estudo longitudinal prospectivo. A amostra foi de 13 pacientes submetidos à biópsia renal percutânea, com 65 avaliações. Os pacientes foram avaliados em cinco momentos nas 24 horas após o procedimento, por meio de um instrumento desenvolvido pelos pesquisadores com base em cinco resultados (Coagulação sanguínea, Estado circulatório, Gravidade da perda de sangue, Nível de dor, Estado de conforto: físico) e 11 indicadores. Utilizou-se o Teste de Equações de Estimação Generalizadas para comparação entre os escores dos indicadores. O projeto foi aprovado pelo comitê de ética institucional. Resultados: nas 65 avaliações foi identificada diferença estatisticamente significativa na redução dos escores dos resultados de enfermagem Coagulação sanguínea, indicador "hematúria"; Estado circulatório, nos indicadores "pressão arterial sistólica e pressão arterial diastólica" e no Estado de conforto: físico, no indicador "bem-estar físico". Conclusão: os pacientes avaliados não apresentaram complicações maiores. Os indicadores clínicos apontaram alterações no estado circulatório, com redução da pressão arterial, bem como na coagulação sanguínea constatada pela hematúria, porém sem instabilidade hemodinâmica. O estado de conforto foi afetado pelo tempo de repouso após o procedimento.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Outcome and Process Assessment, Health Care , Biopsy , Blood Coagulation , Prospective Studies , Longitudinal Studies , Nephrology Nursing , Hematuria , Hemodynamics , Nursing Process
13.
Braz. j. med. biol. res ; 54(7): e10865, 2021. tab, graf
Article in English | LILACS | ID: biblio-1249318

ABSTRACT

This study verified the effects of respiratory muscle training (RMT) on hemodynamics, heart rate (HR) variability, and muscle morphology in rats with streptozotocin-induced diabetes mellitus (DM). Thirty-six male Wistar rats were randomized into 4 groups and 34 completed the study: i) sham-sedentary (Sham-ST; n=9); ii) sham-RMT (Sham-RMT; n=9); iii) DM-sedentary (DM-ST; n=8); and iv) DM-RMT (DM-RMT; n=8). Hemodynamics were assessed by central cannulation, and R-R intervals were measured by electrocardiogram. In addition, the effects of RMT on the cross-sectional area of the diaphragm, anterior tibial, and soleus muscles were analyzed. The induction of DM by streptozotocin resulted in weight loss, hyperglycemia, reduced blood pressure, and attenuated left ventricular contraction and relaxation (P<0.05). We also observed a decrease in root mean square of successive differences between adjacent RR intervals (RMSSD) index and in the cross-sectional area of the muscles assessed, specifically the diaphragm, soleus, and anterior tibial muscles in diabetic rats (P<0.05). Interestingly, RMT led to an increase in RMSSD in rats with DM (P<0.05). The induction of DM produced profound deleterious changes in the diaphragmatic and peripheral muscles, as well as impairments in cardiovascular hemodynamics and autonomic control. Nevertheless, RMT may beneficially attenuate autonomic changes and improve parasympathetic modulation.


Subject(s)
Animals , Male , Rats , Diabetes Mellitus, Experimental , Respiratory Muscles , Breathing Exercises , Rats, Wistar , Heart Rate , Hemodynamics
14.
Einstein (Säo Paulo) ; 19: eRW5630, 2021. tab, graf
Article in English | LILACS | ID: biblio-1286306

ABSTRACT

ABSTRACT Objective To learn about the scientific production on strategies adopted for hemodynamic maintenance of brain-dead patients. Methods Integrative review with articles published between 2007 and 2019, in Scientific Electronic Library Online (SciELO), Latin American and Caribbean Health Sciences Literature (LILACS), PubMed® and ScienceDirect. The descriptors " Hemodinâmica AND Morte Encefálica " and "Hemodynamics AND Brain Death" were used. Exclusion criteria were non-human research and gray literature. Results A total of 21 articles were listed. As strategies, the use of drugs - noradrenaline (n=8), vasopressin (n=7), dobutamine (n=6), hydrocortisone (n=4) and methylprednisolone (n=4); invasive (n=10) and noninvasive (n=13) cardiac monitoring; control of ventilatory parameters (n=12); and correction of fluid and electrolyte disturbances (n=17) were highlighted. Conclusion The main strategies found in this integrative review were regulation of blood pressure and temperature, use of catecholamines and corticosteroids, in addition to the need for an early diagnosis of brain death. However, the lack of clearer protocols on the subject is notorious, making management with the potential donor difficult.


RESUMO Objetivo Conhecer a produção científica sobre estratégias adotadas para a manutenção hemodinâmica de pacientes com morte encefálica. Métodos Revisão integrativa com artigos publicados entre 2007 e 2019, nas bases Scientific Electronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), PubMed®e ScienceDirect . Utilizaram-se os termos "Hemodinâmica AND Morte Encefálica" e "Hemodynamics AND Brain Death ." Os critérios de exclusão foram pesquisas não realizadas com seres humanos e literatura cinzenta. Resultados Listaram-se 21 artigos. Como estratégias, destacaram-se uso de medicamentos - noradrenalina (n=8), vasopressina (n=7), dobutamina (n=6), hidrocortisona (n=4) e metilprednisolona (n=4); monitorização cardíaca invasiva (n=10) e não invasiva (n=13); controle dos parâmetros ventilatórios (n=12); e correção de distúrbios hidroeletrolíticos (n=17). Conclusão As principais estratégias encontradas nesta revisão integrativa foram regulação da pressão arterial e temperatura, uso de catecolaminas e corticosteroides, além da necessidade de um diagnóstico precoce de morte encefálica. Entretanto, é notória a escassez de protocolos mais esclarecidos sobre a temática, dificultando o manejo com o potencial doador.


Subject(s)
Humans , Brain Death , Hemodynamics , Brain , Caribbean Region
15.
Clinics ; 76: e1971, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153993

ABSTRACT

OBJECTIVES: Few studies have investigated whether post-exercise hypotension (PEH) after concurrent exercise (CEX) is related to changes in cardiac output (Q) and systemic vascular resistance (SVR) in older individuals. We tested whether PEH after a single bout of CEX circuits performed in open-access facilities at the Third Age Academies (TAA) in Rio de Janeiro City (Brazil) would be concomitant with decreased Q and SVR in individuals aged ≥60 years with prehypertension. Moreover, we assessed autonomic modulation as a potential mechanism underlying PEH. METHODS: Fourteen individuals (age, 65.8±0.9 y; systolic/diastolic blood pressure [SBP/DBP], 132.4±12.1/72.8±10.8 mmHg; with half of the patients taking antihypertensive medications) had their blood pressure (BP), heart rate (HR), Q, SVR, HR variability (HRV), and spontaneous baroreflex sensitivity (BRS) recorded before and 50 min after CEX (40-min circuit, including seven stations of alternate aerobic/resistance exercises at 60-70% HR reserve) and non-exercise control (CONT) sessions. The study protocol was registered in a World Health Organization-accredited office (Trial registration RBR-7BWVPJ). RESULTS: SBP (Δ=−14.2±13.1 mmHg, p=0.0001), DBP (Δ=−5.2±8.2 mmHg, p= 0.04), Q (Δ=−2.2±1.5 L/min, p=0.0001), and BRS (Δ=−3.5±2.6 ms/mmHg; p=0.05) decreased after CEX as compared with the CONT session. By contrast, the HR increased (Δ=9.4±7.2 bpm, p<0.0001), and SVR remained stable throughout the postexercise period as compared with the CONT session (Δ=0.10±0.22 AU, p=0.14). We found no significant difference between the CEX and CONT with respect to the HRV indexes reflecting autonomic modulation. CONCLUSION: CEX induced PEH in the older individuals with prehypertension status. At least in the first 50 min, PEH occurred parallel to the decreased Q and increased HR, while SVR was not different. The changes in autonomic outflow appeared to be unrelated to the acute cardiac and hemodynamic responses.


Subject(s)
Humans , Middle Aged , Aged , Autonomic Nervous System , Hypertension , Blood Pressure , Brazil , Exercise , Heart Rate , Hemodynamics
16.
Rev. Col. Bras. Cir ; 48: e20202777, 2021.
Article in English | LILACS | ID: biblio-1250709

ABSTRACT

ABSTRACT The spleen is one of the most frequently affected organs in blunt abdominal trauma. Since Upadhyaya, the treatment of splenic trauma has undergone important changes. Currently, the consensus is that every splenic trauma presenting with hemodynamic stability should be initially treated nonoperatively, provided that the hospital has adequate structure and the patient does not present other conditions that indicate abdominal exploration. However, several topics regarding the nonoperative management (NOM) of splenic trauma are still controversial. Splenic angioembolization is a very useful tool for NOM, but there is no consensus on its precise indications. There is no definition in the literature as to how NOM should be conducted, neither about the periodicity of hematimetric control, the transfusion threshold that defines NOM failure, when to start venous thromboembolism prophylaxis, the need for control imaging, the duration of bed rest, and when it is safe to discharge the patient. The aim of this review is to make a critical analysis of the most recent literature on this topic, exposing the state of the art in the NOM of splenic trauma.


RESUMO O baço é um dos órgãos mais frequentemente afetados no trauma abdominal contuso. Desde os trabalhos de Upadhyaya, o tratamento do trauma esplênico vem sofrendo importantes modificações. Atualmente, é consenso que todo trauma esplênico que se apresenta com estabilidade hemodinâmica pode ser tratado inicialmente de forma não operatória, desde que o serviço possua estrutura adequada e o paciente não apresente outras condições que indiquem exploração da cavidade abdominal. Entretanto, vários tópicos permanecem controversos no que diz respeito ao tratamento não operatório (TNO) do trauma esplênico. A angioembolização esplênica é uma ferramenta de grande auxílio no TNO, porém não há consenso sobre suas indicações precisas. Não há uma definição na literatura a respeito da forma como o TNO deve ser conduzido, tampouco a respeito da periodicidade do controle hematimétrico, do limiar de transfusão que define falha do TNO, de quando iniciar a profilaxia contra tromboembolismo venoso, da necessidade de exames de imagem de controle, do período de repouso no leito, e de quando é seguro indicar alta hospitalar. O objetivo desta revisão é analisar de forma crítica a literatura a respeito desse tema, expondo o estado da arte no TNO do trauma esplênico.


Subject(s)
Humans , Wounds, Nonpenetrating/therapy , Abdominal Injuries , Spleen/injuries , Blood Transfusion , Injury Severity Score , Retrospective Studies , Treatment Outcome , Hemodynamics
17.
Rev. méd. Maule ; 36(2): 50-56, dic. 2020. ilus
Article in Spanish | LILACS | ID: biblio-1344677

ABSTRACT

BACKGROUND: Cardiac tamponade is a medical emergency that occurs when fluid accumulates in the pericardial space, its prompt diagnosis and treatment can prevent a fatal outcome. OBJECTIVES: We describe a case of cardiac tamponade in a medicine Ward and its subsequent resolution. CLINICAL CASE: 56-year-old male patient with dyspnoea and edematous síndrome, managed with partial response depletive therapy. Echocardiographic study reveals a large pericardial effusion with signs of cardiac tamponade. Inmediate management with ultrasound-guided pericardiocentesis and subsequent surgical resolution. DISCUSSION: The knowledge of the clinical-hemdynamic manifestations and their subsequent pathophysiological background are important in the diagnostic suspicion and management considerations. Echocardiography is a critical component for the final diagnosis, since given its sensitivity and specificity it allows to complete the characterization of the pericardial effusion. In addition, it contributes to reducing the morbidity associated with its drainage.


Subject(s)
Humans , Male , Middle Aged , Pericardial Effusion/diagnosis , Pericardial Effusion/therapy , Cardiac Tamponade/diagnosis , Cardiac Tamponade/therapy , Echocardiography , Cardiology , Hemodynamics
18.
Arq. bras. cardiol ; 115(4): 680-687, out. 2020. graf
Article in Portuguese | LILACS, SES-SP | ID: biblio-1131356

ABSTRACT

Resumo Fundamento O implante valvar aórtico percutâneo (TAVR, do inglês Transcatheter Aortic Valve Replacement) reduz a mortalidade de pacientes portadores de estenose aórtica grave. O conhecimento da distribuição da pressão e tensão de cisalhamento na parede aórtica pode ajudar na identificação de regiões críticas, onde o processo de remodelamento aórtico pode ocorrer. Neste trabalho é apresentado um estudo de simulação computacional da influência do posicionamento do orifício valvar protético na hemodinâmica na raiz de aorta e segmento ascendente. Objetivos A presente análise apresenta um estudo da variação do padrão de fluxo devido a alterações no ângulo do orifício valvar. Métodos Um modelo tridimensional foi gerado a partir do exame de angiotomografia computadorizada da aorta de um paciente que foi submetido ao procedimento de TAVR. Diferentes vazões de fluxo foram impostas através do orifício valvar. Resultados Pequenas variações no ângulo de inclinação causaram mudanças no padrão de fluxo, com deslocamento na posição dos vórtices, na distribuição de pressão e no local de alta tensão cisalhante na parede aórtica. Conclusão Essas características hemodinâmicas podem ser importantes no processo de remodelamento aórtico e distribuição de tensão, além de auxiliar, em um futuro próximo, a otimização do posicionamento da prótese valvar percutânea. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)


Abstract Backgroud Transcatheter aortic valve replacement (TAVR) can reduce mortality among patients with aortic stenosis. Knowledge of pressure distribution and shear stress at the aortic wall may help identify critical regions, where aortic remodeling process may occur. Here a numerical simulation study of the influence of positioning of the prosthetic valve orifice on the flow field is presented. Objective The present analysis provides a perspective of great variance on flow behavior due only to angle changes. Methods A 3D model was generated from computed tomography angiography of a patient who had undergone a TAVR. Different mass flow rates were imposed at the inlet valve. Results Small variations of the tilt angle could modify the nature of the flow, displacing the position of the vortices, and altering the prerssure distribution and the location of high wall shear stress. Conclusion These hemodynamic features may be relevant in the aortic remodeling process and distribution of the stress mapping and could help, in the near future, the optimization of the percutaneous prosthesis implantation. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)


Subject(s)
Humans , Aortic Valve Stenosis/diagnostic imaging , Heart Valve Prosthesis , Heart Valve Prosthesis Implantation , Transcatheter Aortic Valve Replacement/adverse effects , Aorta , Aortic Valve/surgery , Aortic Valve/diagnostic imaging , Aortic Valve Stenosis/surgery , Prosthesis Design , Treatment Outcome , Computed Tomography Angiography , Hemodynamics
19.
Rev. colomb. cardiol ; 27(5): 428-433, sep.-oct. 2020. tab
Article in Spanish | LILACS, COLNAL | ID: biblio-1289253

ABSTRACT

Resumen La arteritis de Takayasu es una enfermedad de etilogía un poco incierta por la diversidad de factores que pueden afectarla. Sus manifestaciones radican en la afección vascular que produce, en cuyo caso la aorta y sus grandes vasos son los más afectados. Esta vasculitis parece más prevalente en el suroeste asiático, y a pesar de llevar varios años de su descripción, en Europa y América solo se encuentran series de casos de la misma, lo que podría indicar un posible subdiagnóstico. Es importante conocer esta vasculitis ya que su manejo oportuno puede evitar el avance de la enfermedad y la presentación de complicaciones vasculares. El tratamiento de un paciente con arteritis de Takayasu seguirá siendo un desafío para los clínicos ya que no se cuenta con un estándar de manejo; por consiguiente, las decisiones generalmente se basan en recomendación de expertos, por lo cual cada caso deberá individualizarse con el objetivo de ofrecer el manejo más adecuado a los pacientes y disminuir la aparición de complicaciones.


Abstract Takayasu's arteritis is a disease of uncertain origin due to the diversity of factors that can be involved. Its manifestions stem from the vascular involvement that occurs, with the aorta and its large vessels being the most affected. This vasculitis seems more prevalent in south-west Asia, and due to the fact that it has been described for years, and only one series of cases of this disease are found in Europe and America, this could indicate a possible under-diagnosis. It is important to know this vasculitis since its timely management may avoid advancement of the disease, and the presentation of vascular complications. The treatment of a patient with Takayasu's arteritis will follow, being a challenge for clinicians since there is no standard management. For this reason, decisions are generally based on the recommendations by experts, therefore each case will be individualised with the aim of providing the patients with the most suitable management and reducing the appearance of complications.


Subject(s)
Humans , Adult , Vasculitis , Takayasu Arteritis , Cardiology , Hemodynamics , Hypertension
20.
Rev. bras. cir. cardiovasc ; 35(5): 824-830, Sept.-Oct. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1137319

ABSTRACT

Abstract Objective: To investigate the cardiovascular effects produced by transthoracic application of low-intensity pulsed ultrasound therapy (LIPUST). Methods: Three-month-old male Wistar rats (± 300 g, N=16) were randomly allocated in two groups, namely SHAM (control group, faked procedures) and UST (animals treated with LIPUST). These animals, under anesthesia, were instrumented (femoral artery and vein catheterization) for hemodynamic recordings (mean blood pressure [MBP], heart rate [HR]) and blood biochemical profile (lipids, creatine kinase-myocardial band [CK-MB]). Then, LIPUST (spatial average-temporal average [ISATA] 1-MHz, power 0.1 to 1.2 W/cm2, pulsed 2:8 ms, cycle at 30%, for three minutes) was applied to animals from the UST group, externally to their thorax. SHAM animals were equally manipulated, but without application of ultrasound energy. After the hemodynamic and biochemical measurements, animals were sacrificed, and their hearts were mounted in a Langendorff apparatus for coronary reactivity evaluation. Standard histology techniques were employed to analyze the hearts. Results: LIPUST application caused statistically significant reductions in MBP (92±4 vs. 106±1 mmHg) and HR (345±14 vs. 380±17 rpm) when compared with SHAM procedures. UST rats exhibited higher CK-MB levels (318±55 vs. 198±26 U/dL) and lower plasma triglycerides levels (38±7 vs. 70±10 mg/dL) than SHAM animals. Coronary reactivity was not significantly changed by LIPUST. Cardiac histopathology showed an increase in capillary permeability in treated animals when compared with SHAM animals. Conclusion: Noninvasive LIPUST induces significant metabolic and hemodynamic changes, including intensity-dependent bradycardia and hypotension, indicating a possible therapeutic effect for cardiac events.


Subject(s)
Animals , Male , Rats , Bradycardia/therapy , Hypotension , Myocardium , Rats, Wistar , Ultrasonic Waves , Heart , Hemodynamics
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