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1.
Arq. neuropsiquiatr ; Arq. neuropsiquiatr;75(8): 580-588, Aug. 2017. tab, graf
Article in English | LILACS | ID: biblio-888309

ABSTRACT

ABSTRACT The polyspecific antibody synthesis in multiple sclerosis (MS) gained diagnostic relevance with the frequent combination of measles-, rubella- and varicella zoster antibodies (MRZ-antibody reaction) but their pathophysiological role remains unknown. This review connects the data for intrathecal polyspecific antibody synthesis in MS and neurolupus with observations in the blood of patients with Guillain-Barré syndrome (GBS). Simultaneously increased antibody and autoantibody titers in GBS blood samples indicate that the polyspecific antibodies are based on a general property of an immune network, supported by the deterministic day-to-day concentration variation of antibodies in normal blood. Strongly correlated measles- and rubella- antibody variations point to a particular connectivity between the MRZ antibodies. The immune network, which provides serological memory in the absence of an antigen, implements the continuous change of the MRZ pattern in blood, not followed by the earlier immigrated B cells without corresponding connectivity in the brain. This may explain the different antibody patterns in cerebrospinal fluid, aqueous humor and blood of the individual MS patient. A complexity approach must implement a different view on causation in chronic diseases and causal therapies.


RESUMO A síntese de anticorpos poliespecíficos em esclerose múltipla (EM) ganhou relevância diagnóstica com a combinação frequente de anticorpos contra sarampo, rubéola e varicela-zoster (reação de anticorpos MRZ), mas seu papel fisiopatológico permanece desconhecido. Esta revisão relaciona os dados da síntese intratecal de anticorpos poliespecíficos em EM e Neurolupus com observações no sangue de pacientes com síndrome de Guillain Barré (SGB). Simultaneamente, os títulos aumentados de anticorpos e autoanticorpos em amostras de sangue de SGB indicam que os anticorpos poliespecíficos se baseiam numa propriedade geral de uma rede imunitária, suportada pela variação determinística da concentração diária de anticorpos no sangue normal. As variações fortemente correlacionadas de anticorpos contra sarampo e rubéola apontam para uma conectividade particular entre os anticorpos MRZ. A rede imunitária, que fornece memória sorológica na ausência de um antígeno, implementa a mudança contínua do padrão MRZ no sangue, não seguida pelas células B que imigraram anteriormente sem conectividade no cérebro. Isto pode explicar os diferentes padrões de anticorpos no LCR, humor aquoso e sangue do paciente individual de EM. Uma abordagem complexa deve implementar uma visão diferente sobre a causalidade em doenças crônicas e terapias causais.


Subject(s)
Humans , Guillain-Barre Syndrome/immunology , Antibodies, Viral/blood , Multiple Sclerosis/immunology , Antibody Specificity/immunology , Rubella/immunology , Immunoglobulin G/blood , Cerebrospinal Fluid/chemistry , Herpes Zoster/immunology , Measles/immunology , Antibodies, Bacterial , Multiple Sclerosis/cerebrospinal fluid , Mumps/immunology , Antigens, Viral/immunology
3.
An. bras. dermatol ; An. bras. dermatol;89(6): 985-987, Nov-Dec/2014. graf
Article in English | LILACS | ID: lil-727625

ABSTRACT

Herpes zoster-associated urinary retention is an uncommon event related to virus infection of the S2-S4 dermatome. The possible major reasons are ipsilateral hemicystitis, neuritis-induced or myelitis-associated virus infection. We report a case of a 65-year-old immunocompetent female patient who presented an acute urinary retention after four days under treatment with valacyclovir for gluteal herpes zoster. The patient had to use a vesical catheter, was treated with antibiotics and corticosteroids and fully recovered after eight weeks.


Subject(s)
Aged , Female , Humans , Exanthema/virology , Herpes Zoster/complications , Immunocompetence , Urinary Retention/virology , Acyclovir/analogs & derivatives , Acyclovir/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Antiviral Agents/therapeutic use , Exanthema/drug therapy , Herpes Zoster/drug therapy , Herpes Zoster/immunology , Immunocompetence/immunology , Treatment Outcome , Valine/analogs & derivatives , Valine/therapeutic use
4.
Arch. oral res. (Impr.) ; 9(2): 135-140, May-Aug. 2013. ilus
Article in Portuguese | LILACS | ID: lil-754535

ABSTRACT

O herpes-zóster é uma infecção viral causada pela reativação do vírus da varicela-zóster. Esta doença pode afetar pacientes imunossuprimidos e caracteriza-se por lesões papulovesiculares distribuídas na região inervada pelo nervo afetado, causando dores intensas. Este artigo relata o caso de um paciente do sexo masculino, leucoderma, 26 anos de idade, dependente químico, HIV positivo e com tuberculose ganglionar que procurou o Hospital Oswaldo Cruz (Curitiba/PR) tendo como queixa mal-estar geral, lesões na pele e mucosa oral, e linfadenopatia na região cervical. Discussão: O diagnóstico do herpes-zóster foi estabelecido por meio das características clínicas das lesões, e o tratamento estabelecido envolveu o uso de drogas antirretrovirais, analgésicos e antidepressivos. Conclusão: O cirurgião-dentista precisa estar atento às lesões papulovesiculares que acometem a pele e as mucosas de forma unilateral, acompanhadas de sintomas de prurido e dor, pois elas garantem o diagnóstico do herpes-zóster...


Herpes zoster is a viral infection caused by the reactivation of varicella zoster virus. This disease can affect immunocompromised patients and is characterized by papulovesicular lesions distributed in the inner¬vated region by the affected nerve and may result in severe pain. This article reports the case of a male patient, leucoderm, 26 years old, user of illicit drugs, HIV positive and with lymph node tuberculosis, who came to the hospital Oswaldo Cruz (Curitiba, Paraná, Brazil), having as general complaint malaise, skin and oral lesions, and cervical lymphadenopathy. Discussion: The diagnosis of herpes zoster has been established by clinical characteristics of the lesions and established treatment involved the use of antiretroviral drugs, analgesics and antidepressants. Conclusion: The dentist needs to be aware of papulovesicular lesions affecting the skin and mucous membranes unilaterally followed by symptoms of pruritus and pain, for these ensure the diagnosis of herpes zoster...


Subject(s)
Humans , Male , Adult , Herpes Zoster/immunology , Herpes Zoster/pathology , AIDS-Related Opportunistic Infections/pathology , Herpes Zoster/drug therapy , Mouth Mucosa/pathology , Skin/pathology
5.
Braz. j. infect. dis ; Braz. j. infect. dis;12(4): 313-315, Aug. 2008. ilus
Article in English | LILACS | ID: lil-496770

ABSTRACT

Since the introduction of varicella vaccination in India, surveillance of circulating VZV strains has gained significance. Differentiating wild-type VZV strains from the Oka vaccine strain can be achieved only by molecular genotyping methods. The development of PCR methods for VZV strain differentiation has been hampered by the fact that the VZV genome is highly conserved. We used VZV ORF 62 PCR-RFLP analysis to identify and differentiate wild-type VZV strains in India from the Oka vaccine strain. Digestion of VZV ORF 62 amplicons with SmaI, enabled accurate strain differentiation; the Oka strain was positive for three SmaI sites, compared to two SmaI sites in the wild-type VZV strains that we tested.


Subject(s)
Humans , Chickenpox Vaccine/immunology , Chickenpox/virology , Herpes Zoster/virology , /genetics , Open Reading Frames/genetics , Chickenpox Vaccine/genetics , Chickenpox/immunology , DNA, Viral/analysis , Genotype , Herpes Zoster/immunology , /classification , /immunology , India , Polymerase Chain Reaction , Polymorphism, Restriction Fragment Length
6.
J. pediatr. (Rio J.) ; J. pediatr. (Rio J.);82(3,supl): s115-s124, jul. 2006.
Article in Portuguese | LILACS, SES-SP | ID: lil-433967

ABSTRACT

OBJETIVOS: As vacinas contra o estreptococo B, o herpes-zóster, o HIV, a malária e a dengue, selecionadas por critérios de comercialização iminente ou devido a problemas específicos para sua obtenção, foram objeto de uma revisão sobre o estado atual do seu desenvolvimento. FONTE DOS DADOS:Foi realizada revisão da literatura através da MEDLINE no período de 1996 a 2006, sobre a epidemiologia e imunologia das doenças, analisando tanto os maiores problemas para a obtenção de uma vacina como o estado atual dos estudos, com ênfase para os que estavam em fase mais adiantada. SíNTESE DOS DADOS: Cada uma das cinco doenças escolhidas apresenta problemas específicos para o desenvolvimento de uma vacina. No entanto, a maioria deles já foi ou está em vias de ser resolvido, permitindo prever que uma vacina - ou vacinas - eficaz e segura estará disponível em futuro próximo. CONCLUSÕES:Apesar dos problemas enfrentados para o desenvolvimento dessas vacinas, os avanços da biologia molecular e da imunologia permitiram superar a maioria deles, abrindo a perspectiva para a obtenção de novas vacinas.


Subject(s)
Humans , Acquired Immunodeficiency Syndrome/prevention & control , Dengue/prevention & control , Herpes Zoster/prevention & control , Malaria/prevention & control , Streptococcal Infections/prevention & control , Vaccines/therapeutic use , AIDS Vaccines/immunology , Acquired Immunodeficiency Syndrome/immunology , Clinical Trials as Topic , Dengue Vaccines/immunology , Dengue/immunology , Herpes Zoster Vaccine/immunology , Herpes Zoster/immunology , Malaria Vaccines/immunology , Malaria/immunology , Streptococcal Infections/immunology , Streptococcal Vaccines/immunology , Streptococcus agalactiae/immunology , Vaccines/immunology , Global Health
7.
Pediatria (Säo Paulo) ; 18(3): 134-45, jul.-set. 1996.
Article in Portuguese | LILACS | ID: lil-186886

ABSTRACT

A vacina contra a varicela e altamente imunogênica e protetora, porém, desde o início da década de 70, quando a vacina contendo a cepa Oka foi desenvolvida no Japäo, tem havido muita discussäo sobre o risco da vacinaçäo de crianças promover um aumento do número de casos de zoster ou de varicela em adultos se a imunidade näo for persistente...


Subject(s)
Humans , Chickenpox/immunology , Herpes Zoster/immunology , Vaccination/trends , Chickenpox/epidemiology , Chickenpox/prevention & control , Exanthema/etiology , Host-Parasite Interactions
8.
Rev. méd. Hosp. Gen. Méx ; 58(4): 148-50, oct.-dic. 1995. tab
Article in Spanish | LILACS | ID: lil-180612

ABSTRACT

La infección por virus del herpes es una complicación severa del SIDA. Alentados por nuestra excelente experiencia previa en el tratmiento de la infección por virus del herpes en otros pacientes inmunocomprometidos, decidimos utilizar factor de transferencia en pacientes con SIDA complicados con infección por virus del herpes. Hemos tratado siete enfermos: uno con varicerla, cinco con herpes zoster y uno con herpes simple diseminado más candidiasis bucoesofágica, neumonía y derrame pleural. La evolución previa al factor de transferencia era de cinco a 35 días. Tres pacientes habían recibido aciclovir sin ninguna respuesta. La infección por virus del herpes era severa en todos. El factor de transferencia se administró solo (4) o sociado a aciclovir (2) o isoprinosina (1) hasta la desaparición de las lesiones habiéndose requerido de cinco a 13 dosis. El factor de transferencia fue eficaz en todos, aun en los que no respondieron al aciclovir, pese a que se inició tardíamente en el curso de la infección por virus del herpes en los siete casos. El factor de transferencia parece, pues, una alternativa útil en el tratamiento de infección por virus del herpes severa en los enfermos con SIDA y amerita estudios más amplios en estadios más tempranos del herpes


Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Transfer Factor/therapeutic use , Herpes Zoster/immunology , Herpes Zoster/therapy , Acquired Immunodeficiency Syndrome/complications
9.
Dermatol. rev. mex ; 39(4): 197-201, jul.-ago. 1995. tab, ilus
Article in Spanish | LILACS | ID: lil-161923

ABSTRACT

Estudio dermatológico e histopatológico en 46 pacientes con infección VIH/SIDA. Se hizo clasificación clínica y de su subpoblaciones de linfocitos de acuerdo con los criterios del CDC, pero no se encontró relación estadísticamente significativa. Las dermatosis se presentaron en 77 por ciento de los casos y las más frecuentes fueron: sarcoma de Kaposi (18.9 por ciento), molusco contagioso (16.8 por ciento), dermatitis seborreica (12.6 por ciento), herpes zoster (10.5 por ciento), reacciones a fármacos (10.5 por ciento) y candidosis oral (8.4 por ciento)


Subject(s)
Adult , Humans , Male , Female , CD4-Positive T-Lymphocytes/immunology , Herpes Zoster/diagnosis , Herpes Zoster/immunology , HIV Infections/classification , HIV Infections/physiopathology , Molluscum Contagiosum/diagnosis , Molluscum Contagiosum/immunology , Sarcoma, Kaposi/diagnosis , Sarcoma, Kaposi/etiology , Acquired Immunodeficiency Syndrome/classification , Acquired Immunodeficiency Syndrome/physiopathology
10.
Article in English | IMSEAR | ID: sea-35319

ABSTRACT

During 1982-1983, susceptibility to varicella-zoster virus (VZV) in 224 Thai subjects at high risk for varicella infection was studied. The immune adherence hemagglutination (IAHA) and VZ skin test were carried out to determine VZV immunity in immunocompromised children and young adults. The history of varicella and herpes zoster from each subject was recorded. The mean +/- SD age in children and young adults were 7.3 +/- 2.8 and 19.6 +/- 1.2. Negative IAHA test was found in 74.2% of 62 children and 35.2% of 162 young adults. The increase in immune individuals was demonstrated with advancing age. Response to VZ skin test showed positive results in 79 of 162 (48.8%) young adults. The seronegativity was related to the negative VZ skin test (p less than 0.001, X2 test). Regardless of antibody detection or VZ skin test, 47 of 162 (29%) young adults were susceptible. According to the positive history of varicella and of herpes zoster obtained from 95 young adults, 80% had developed varicella during 1 to 10 years of age and 8.8% had positive history of herpes zoster. The findings suggest that the IAHA and VZ skin test should be used together for assessing VZ immunity. Varicella vaccination is highly recommended for susceptible persons who may develop severe illness.


Subject(s)
Adolescent , Adult , Antibodies, Viral/analysis , Child , Child, Preschool , Disease Susceptibility , Hemagglutination Tests , Herpes Zoster/immunology , Herpesvirus 3, Human/immunology , Humans , Immune Adherence Reaction , Skin Tests , Thailand
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