Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 1.827
Filter
1.
Vitae (Medellín) ; 28(3): 1-7, 2021-08-11. Ilustraciones
Article in English | LILACS, COLNAL | ID: biblio-1363276

ABSTRACT

Background: The bulb of Allium cepa Linnaeus (onion) is used in traditional medicine as an antidiabetic, antioxidant, antihypertensive, anti-inflammatory, and antihyperlipidemic, among others. The lack of information or little knowledge about the effects of Allium cepa L. on skin lesions, specifically burn wounds, arouses interest in studying its effects on these skin disorders. Objective: This study assessed the wound healing activity of Allium cepa L. on second-degree burns induced in Holtzman rats. Method: Thirty-two albino rats were randomly distributed into four groups of 8 rats each, including the Healthy group, the Control group, the Experimental group (Alliumcepa L.), and the Standard group (1% silver sulfadiazine). Burn wounds were induced, and topical treatments were performed daily for 21 days. The reduction of the burned body area (mm2) was determined during the experimental time. Albino rats were sacrificed with an excess of surgical anesthesia to obtain tissue samples for histopathological analysis. Results: Standard and experimental groups significantly reduced burned body area (p<0.01) compared to the control group. Histopathological studies showed hyperemic chorion in the Control group, fibroblasts, and collagen in the Standard group, and dermis composed of a reticular stratum of fibroblasts, collagen, and few blood vessels in the Experimental group. Conclusion: Allium cepa L. revealed wound-healing activity on burns induced in Holtzman rats and reduced the damage produced by burns


Antecedentes: El bulbo de Alliumcepa L. (cebolla) se utiliza en medicina tradicional como antidiabético, antioxidante, antihipertensivo, antiinflamatorio, anti hiperlipidémico entre otros. La falta de información o muy poco conocimiento acerca de los efectos de Allium. cepa L. en lesiones cutáneas, específicamente en las heridas por quemaduras, despierta el interés por estudiar sus efectos en estas afectaciones cutáneas. Objetivo: El objetivo de este estudio fue evaluar la actividad cicatrizante de Allium. cepa L. en quemaduras de segundo grado inducidas en ratas Holtzman. Método: Se utilizaron treinta y dos ratas albinas distribuidas al azar en cuatro grupos de ocho ratas cada uno, incluyendo el Grupo sano, el Grupo Control, el Grupo Experimental (Allium cepa L.) y el Grupo Estándar (Sulfadiazina de plata al 1%). Se indujo la herida por quemadura, y los tratamientos tópicos se realizaron diariamente durante 21 días. La reducción del área corporal quemada (mm2) se determinó durante el tiempo de experimentación, luego los animales fueron sacrificados con exceso de anestesia quirúrgica para obtener las muestras de tejidos para el estudio histopatológico. Resultados: Los grupos estándar y experimental mostraron reducción significativa en el área corporal quemada (p<0,01) comparadas al grupo control. El estudio histopatológico evidenció corion hiperémico en el grupo control; fibroblastos y colágeno en el grupo estándar y dermis integrada por un estrato reticular de fibroblastos, colágeno y pocos vasos sanguíneos en el grupo experimental. Conclusión: Alliumcepa L. reveló actividad cicatrizante en quemaduras inducidas en ratas Holtzman, y disminuyó el daño producido por las quemaduras


Subject(s)
Humans , Phytochemicals , Silver Sulfadiazine , Burns , Onions , Histology
2.
Rev. colomb. cir ; 36(4): 719-725, 20210000. fig
Article in Spanish | LILACS | ID: biblio-1291270

ABSTRACT

Introducción. Los quistes gástricos de duplicación son malformaciones congénitas muy infrecuentes del tracto gastrointestinal. Se definen como una lesión quística tapizada por epitelio gastrointestinal que comparte una capa de músculo liso con la pared gástrica. Se han propuesto diferentes teorías sobre su patogénesis, sin embargo, los eventos embriológicos que conducen a la malformación no han logrado ser dilucidados. Debido a su localización y presentación clínica, el diagnóstico se realiza con mayor frecuencia durante los primeros años de vida y existen pocos casos reportados en adultos, en quienes el hallazgo suele ser incidental. Caso clínico. Se presenta el caso de una mujer de 65 años quien consultó por dolor abdominal crónico y síntomas digestivos inespecíficos. Por medio de Tomografía Axial Computarizada se evidenció una lesión quística en contacto con el páncreas y la pared gástrica. Se realizó exploración quirúrgica que, junto con los hallazgos histopatológicos, confirmó el diagnosticó de quiste de duplicación gástrico. Discusión. Los quistes de duplicación gástrica son anomalías excepcionales que se localizan más frecuentemente en la curvatura mayor. Su tratamiento es quirúrgico y la confirmación del diagnóstico se realiza mediante la histología


Introduction. Gastric duplication cysts are very rare congenital malformations of the gastrointestinal tract. They are defined as a cystic lesion lined by gastrointestinal epithelium that shares a layer of smooth muscle with the gastric wall. Different theories have been proposed about its pathogenesis, however, the embryological events that lead to the malformation have not been elucidated. Due to its location and clinical presentation, the diagnosis is made more frequently during the first years of life and there are few cases reported in adults, in whom the finding is usually incidental. Clinical case. We present the case of a 65-year-old woman who consulted for chronic abdominal pain and nonspecific digestive symptoms. A CT scan evidenced a cystic lesion in contact with the pancreas and the gastric wall. A surgical exploration was performed which, along with the histopathological findings, confirmed the diagnosis of a gastric duplication cyst. Discussion. Gastric duplication cysts are exceptional anomalies that are more frequently located in the greater curvature. Its treatment is surgical and the confirmation of the diagnosis is made by histology


Subject(s)
Humans , Cysts , Gastrointestinal Tract , General Surgery , Histology
3.
Rev. colomb. cir ; 36(4): 726-731, 20210000. fig
Article in Spanish | LILACS | ID: biblio-1291273

ABSTRACT

Introducción. Los quistes mesoteliales benignos son una entidad poco frecuente, que ocurren especialmente en mujeres en edad reproductiva. Se deben a una proliferación anómala del mesotelio que puede ser originada en varias estructuras intraabdominales e inicialmente es asintomática. Caso clínico. Se presenta el caso de una mujer de 20 años con un cuadro sugestivo de neoplasia maligna, en quien se confirmó el diagnóstico de quiste mesotelial originado en la trompa de Falopio derecha. Se realizó tratamiento quirúrgico exitoso. Discusión. A pesar de la estrecha relación de esta entidad con el útero y los ovarios, no se encuentran reportes de quistes mesoteliales originados a partir de las trompas de Falopio. El tratamiento de los quistes mesoteliales es quirúrgico y en el caso de esta paciente se hizo con la finalidad de mejorar los síntomas y erradicar la enfermedad. Las decisiones fueron tomadas basadas en la opinión de expertos en oncología en una junta de tumores gastrointestinales. Conclusiones. Los quistes mesoteliales son neoplasias de baja incidencia, pero se deben tener en cuenta como diagnóstico diferencial de los tumores abdominales. Se presenta el caso de una paciente tratada de forma quirúrgica con resultados exitosos y seguimiento a un año sin recurrencias


Introduction. Benign mesothelial cysts (BMC) are a rare entity that occurs especially in women of reproductive age. It is due to an abnormal proliferation of the mesothelium that can originate from various intra-abdominal structures and it is initially asymptomatic. Clinical case. This is a case of a 20-year-old woman with a suspicious malignant neoplasia, in whom the diagnosis of a mesothelial cyst originating in the right Fallopian tube was confirmed. Successful surgical treatment was achieved. Discussion. Despite the close relationship of this entity with the uterus and ovaries, there are no reports of me-sothelial cysts originating from the Fallopian tubes. The treatment of mesothelial cysts is surgical and in the case of this patient it was performed in order to improve the symptoms and eradicate the disease. The decisions were taken based on the oncologists' expert opinion of the gastrointestinal tumor board. Conclusions. Mesothelial cysts are neoplasms of low incidence, but they should be considered as a differential diagnosis of abdominal tumors. The case of a patient treated surgically with successful results and a one-year follow-up without recurrences is presented


Subject(s)
Humans , Mesothelioma, Cystic , Fallopian Tubes , Histology , Laparotomy , Neoplasms
4.
Rev. colomb. gastroenterol ; 36(supl.1): 12-18, abr. 2021. graf
Article in Spanish | LILACS | ID: biblio-1251540

ABSTRACT

Resumen Las vasculitis leucocitoclásticas se definen como el daño e inflamación de las paredes vasculares, son aquellas vasculitis de pequeños vasos que anatomopatológicamente presentan leucocitoclasia y puede observarse como una manifestación extraintestinal de la enfermedad inflamatoria intestinal. En la colitis ulcerativa se presentan en menor frecuencia, por inmunocomplejos generados en la mucosa intestinal debido a la exposición del tejido linfoide submucoso a antígenos fecales; podrían precipitarse en las paredes de los pequeños vasos. Se pueden asociar con Clostridium difficile, que es un bacilo grampositivo esporulado, anaerobio estricto, que se encuentra normalmente en el medio ambiente y produce colitis, que se manifiesta como un cuadro diarreico presentado después de la ingesta de antibióticos y altera la flora bacteriana común de este órgano. El caso se trata de un paciente 36 años de edad con cuadro de diarreas líquidas con moco y escaso sangrado; se realizó un estudio endoscópico y anatomopatológico en el que se observó colitis ulcerativa con coproparasitario positivo para antígeno de C. difficile, y en su hospitalización presentó lesiones dérmicas petequiales y necróticas en el cuarto dedo de la mano izquierda, que en la biopsia dio como resultado vasculitis de pequeños vasos. En este artículo se revisan de forma práctica los aspectos relacionados con la fisiopatología, histología, tratamiento y diagnósticos de la manifestación extraintestinal dermatológica rara, como la vasculitis leucocitoclástica en pacientes con colitis ulcerativas asociadas con Clostridium.


Abstract Leukocytoclastic vasculitis is defined as the damage and inflammation of the vascular walls. The term refers to vasculitis of the small vessels that anatomopathologically present leukocytoclasia and it can be seen as an extra-intestinal manifestation of inflammatory bowel disease. In ulcerative colitis, it occurs less frequently due to immune complexes produced in the intestinal mucosa by exposure of the submucosal lymphoid tissue to fecal antigens, which could precipitate in the walls of the small vessels. This condition can be associated with Clostridium difficile, which is a gram-positive, sporulated, strict anaerobic bacillus, normally found in the environment. It causes colitis that manifests as a diarrheal disease following the ingestion of antibiotics that alter the common bacterial flora of this organ. This is the case report of a 36-year-old patient with liquid diarrhea with mucus and scarce bleeding. Endoscopic and anatomopathological studies were performed, finding ulcerative colitis with positive coproparasite for Clostridium difficile antigen. The patient was hospitalized, and during his stay, he presented with petechiae and necrotic skin lesions on the fourth finger of the left hand. Skin biopsy showed small vessel vasculitis. This article is a practical review of the pathophysiology, histology, treatment, and diagnosis of a rare dermatologic extraintestinal manifestation, namely, leukocytoclastic vasculitis, in patients with C. difficile-associated ulcerative colitis.


Subject(s)
Humans , Male , Adult , Vasculitis , Inflammatory Bowel Diseases , Colitis, Ulcerative , Clostridioides difficile , Skin , Therapeutics , Diarrhea , Fingers , Histology
5.
Rev. argent. cir ; 113(1): 121-124, abr. 2021. graf
Article in Spanish | LILACS, BINACIS | ID: biblio-1288182

ABSTRACT

RESUMEN La neoplasia papilar intracolecística con carcinoma mucinoso invasor y células en anillo de sello es una variedad de cáncer de vesícula, una patología agresiva y con mal pronóstico, la cual puede presentarse en forma similar a una colecistitis y, a pesar del tratamiento operatorio y quimioterapia posterior, la supervivencia y pronóstico son peores en relación con los otros cánceres de vesícula. Este artículo tie ne por objetivo describir un tipo histológico muy específico, de baja frecuencia, de cáncer de vesícula y el tratamiento realizado.


ABSTRACT Intracholecystic papillary neoplasm with invasive mucinous adenocarcinoma and signet ring cells is a rare, aggressive variety of gallbladder cancer, with symptoms mimicking cholecystitis. Survival and prognosis are worse that other types of gallbladder cancer despite surgery and chemotherapy. The aim of this article is to describe a case of a rare gallbladder cancer with specific histology and the treatment performed


Subject(s)
Humans , Male , Aged , Gallbladder Neoplasms , Pathology , Survival , Therapeutics , Grief , Cells , Baja , Blister , Drug Therapy , Gallbladder , Histology , Neoplasms
7.
Rev. cient. odontol ; 8(3): e034, sept.-dic. 2020. ilus
Article in Spanish | LILACS, LIPECS | ID: biblio-1253440

ABSTRACT

El quiste dentígero y el ameloblastoma son patologías con poca sintomatología y características clínicas, las cuales son evidentes cuando las lesiones alcanzan dimensiones mayores y esto sucede cuando llevan un tiempo considerable de evolución, por lo cual son descubiertas generalmente en exámenes radiográficos de rutina. El presente artículo describe los hallazgos histológicos y su correlación clínico-patológica y radiográfica entre el quiste dentígero y el ameloblastoma, lo que permite un diagnóstico y un plan de tratamiento. Se presentan dos casos de pacientes masculinos, de 12 y 15 años, que asisten a consulta a la Facultad de Odontología de la Universidad de Cartagena en Colombia, por presentar tumefacción en zona de sínfisis mandibular y en zona de tercer molar inferior derecho. Se especifican hallazgos clínicos, radiográficos e histológicos. Para llegar a los diagnósticos de quiste dentígero y ameloblastoma se deben tener en cuenta todos los hallazgos del examen clínico y radiográfico, pero debe primar el dictamen del examen histopatológico para determinar un tratamiento adecuado. (AU)


Dentigerous cysts and ameloblastomas present with few symptoms, and clinical characteristics present when lesions reach larger dimensions following a considerable length of evolution, and thus, these lesions are often discovered in routine radiographic examinations. This study describes the histological findings and clinical, pathological, and radiographic correlations between dentigerous cysts and ameloblastomas which aid in diagnosis and treatment planning. Two male patients, aged 12 and 15, were attended at the Faculty of Dentistry of the Cartagena University in Colombia due to swelling at the mandibular symphysis and lower right third molar area. The clinical, radiographic and histological findings are described. Clinical and radiographic findings must be taken into account to diagnose dentigerous cysts and ameloblastomas, with histopathological examination providing the definitive diagnosis and allowing adequate patient management. (AU)


Subject(s)
Humans , Male , Adolescent , Pathology, Oral , Ameloblastoma , Dentigerous Cyst , Diagnosis, Differential , Histology
8.
Hematol., Transfus. Cell Ther. (Impr.) ; 42(3): 245-251, July-Sept. 2020. tab, graf
Article in English | LILACS | ID: biblio-1134033

ABSTRACT

ABSTRACT Introduction: Acute graft-versus-host disease (GVHD) is one of the major causes of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT) and has become the subject of several studies to understand and treat it. Objective: This study does a descriptive analysis of the apoptotic index (AI) evaluation and intestinal permeability (IP) alterations in association with the clinical, endoscopic and histopathological data on patients undergoing AHSCT, with emphasis on acute intestinal graft-versus-host disease (GVHD) diagnosis. Methods: Thirty-one patients were divided into two groups—one of patients with a clinical GVHD diagnosis and one of those without GVHD diagnosis. Results: Thirteen deaths (41.9%) occurred during the study period, thereby reaffirming the severity of the alterations found in the patients. Fifteen patients subjected to 21 esophagogastroduodenoscopy procedures prior to D + 90 post-transplant had visible endoscopic alterations and 19 biopsies revealed histological alterations to the stomach and duodenum. Higher apoptotic indices, not reaching statistical significance, were observed in patients who died of graft versus host disease (GVHD), in the more acute forms of GVHD and where clinical GVHD was present. The intestinal permeability evaluation was performed on nine patients able to undergo it in the three proposed study periods, which showed alterations, some of which were pronounced even during pre-transplant and, therefore, the pre-conditioning phase. Conclusion: Clinical judgment remains a fundamental tool in the diagnosis of GVHD. This study points to the known limitations of traditional diagnostic aids (endoscopy and histology) and points to new methods not usually employed in clinical practice.


Subject(s)
Humans , Male , Female , Transplantation, Homologous , Biopsy , Endoscopy, Digestive System , Hematopoietic Stem Cell Transplantation , Graft vs Host Disease/diagnosis , Histology
9.
Int. j. morphol ; 38(3): 634-639, June 2020. tab, graf
Article in English | LILACS | ID: biblio-1098299

ABSTRACT

Dental education is in a continuous state of development to adapt to the changing learning strategies of the millennial students. The introduction of electronic learning resources (ELR) is a good example, which has added immense value to the traditional methods of teaching oral histology. The main purpose of the study was to analyze the dental students' perception of learning oral histology the way it was taught. A pre-approved questionnaire survey was electronically distributed to 129 students who had completed the oral histology course. The majority of the students viewed oral histology course to be difficult and irrelevant to their dental career. Similarly, most of them preferred studying alone and used ELR in place of books and atlases. More than three quarters believed using a microscope in practical training sessions will make the oral histology course easier and more interesting. The results of this study will be used to formulate recommendations to be implemented in oral histology course.


La educación dental se encuentra en un estado de desarrollo continuo para adaptarse a las cambiantes estrategias de aprendizaje de los estudiantes milenios. La introducción de recursos de aprendizaje electrónico (RAE) es un buen ejemplo, el cual ha agregado un valor importante a los métodos tradicionales de enseñanza de histología oral. El objetivo principal del estudio fue analizar la percepción de los estudiantes de odontología de aprender histología oral de la forma en que se enseñó. Una encuesta de cuestionario preaprobada se distribuyó electrónicamente a 129 estudiantes que habían completado el curso de histología oral. La mayoría de los estudiantes consideraron que el curso de histología oral era difícil e irrelevante para su carrera dental. Del mismo modo, la mayoría de ellos preferían estudiar solos y usaban RAE en lugar de libros y atlas. Más de las tres cuartas partes creen que usar un microscopio en sesiones de capacitación práctica, permitiría que el curso de histología oral sea más fácil e interesante. Los resultados de este estudio se utilizarán para formular recomendaciones que se implementarán en el curso de histología oral.


Subject(s)
Humans , Students, Dental/psychology , Education, Dental/methods , Mouth/anatomy & histology , Surveys and Questionnaires , Educational Measurement , Histology/education
10.
Rev. argent. mastología ; 39(141): 15-33, mar. 2020. graf
Article in Spanish | LILACS | ID: biblio-1104364

ABSTRACT

Objetivos El objetivo principal del siguiente trabajo es relacionar los hallazgos imagenológicos con los resultados histopatológicos de lesiones mamarias que requirieron biopsia. El primer objetivo secundario es evaluar el grado de subestimación de aquellas lesiones de riesgo a las que se le realizó Biopsia Radioquirúrgica (brq). El segundo objetivo secundario es conocer la sensibilidad y especificidad del bi-rads como método de diagnóstico para nuestra muestra. Material y método Se incluyeron 403 pacientes que fueron biopsiadas en el Centro de Diagnóstico y Tratamiento de Enfermedades Mamarias (cedytem) de la Ciudad de Santa Fe, en el período de tiempo comprendido entre el 1/1/15 y el 31/12/17. Los nódulos fueron punzados bajo guía ecográfica y las microcalcificaciones, asimetrías y distorsiones arquitecturales bajo guía estereotáxica. La concordancia entre los hallazgos imagenológicos e histopatológicos fue analizada teniendo en cuenta la clasificación de Parikh y Tickman. Resultados Se constató una buena relación entre las categorías bi-rads y la probabilidad de malignidad de las lesiones acorde a lo establecido por el Colegio Americano de Radiólogos (acr). Se observó un 100% de concordancia entre las lesiones categorizadas como benignas (bi-rads 3) y un 97% entre las categorizadas como malignas (bi-rads 5). Las lesiones categorizadas en el grupo de moderada a alta sospecha de malignidad (bi-rads 4B y bi-rads 4C) que resultaron benignas fueron reevaluadas para decidir nuevo control en 6 meses, repetir la biopsia o indicar la realización de brq. Se diagnosticaron 17 lesiones de riesgo (4,2%), de las cuales 12 fueron reevaluadas con brq, evidenciando un porcentaje de subestimación del 42%. Conclusiones A partir de los datos obtenidos, se calculó una sensibilidad del bi-rads como método de diagnóstico del 95% y una especificidad del 74%


Objectives The primary aim of the following work is to relate the imaging findings to the histopathological results of breast lesions that required biopsy. The second aim is to evaluate the degree of underestimation of those risk lesions that underwent a radio-surgical biopsy. The last objective is to know the sensibility and specificity of bi-rads as a diagnosis method for our sample. Materials and method This work included four hundred and three patients who were biopsied at Center for the Diagnosis and Treatment of Breast Diseases (cedytem) in the city of Santa Fe, in the time period between 1/1/15 and 12/31/17. The nodules were punctured under ultrasound guidance while microcalcifications, asymmetries and architectural distortions under stereotactic guidance. Results A good relationship was observed between the bi-rads categories and the probability of malignancy of the lesions according to what is established by the American College of Radiologists (acr). The imaging-histopathological findings correlation was evaluated taking into account the classification of Parikh and Tickman. A 100% correlation was observed between lesions categorized as benign (bi-rads 3), and 97% among those categorized as malignant (bi-rads 5). The lesions categorized as moderate or high suspicion of malignancy (birads 4B and bi-rads 4C) which turned out to be benign were re-evaluated to decide on having a new control in 6 months, repeating the biopsy or indicating the radio-surgical biopsy. Seventeen risk lesions (4.2%) were diagnosed of which twelve were reassessed with radio-surgical biopsy, evidencing an underestimation percentage of 42%. Conclusions Based on the data obtained, it was calculated for our sample a 95% sensitivity of the bi-rads and a 74% of specificity as a diagnostic method.


Subject(s)
Biopsy , Breast , Breast Diseases , Histology
11.
Int. j. morphol ; 38(1): 38-42, Feb. 2020. tab
Article in English | LILACS | ID: biblio-1056394

ABSTRACT

Students' perceptions and feedback have a significant impact on academic progress. The aim of this study was to determine the perceptions of medical students regarding the cumulative effects of the first year general histology course and the sophomore pathology introductory course, in addition to their perceptions regarding the curricular integration of histology and pathology. In this cross-sectional study, a questionnaire was given to second-year and third-year medical students in the middle of second semester. The questionnaire comprised several items on students' attitudes toward anatomic pathology, their feedback on the first year general histology and the sophomore pathology courses, and their perceptions regarding the integration of histology and pathology courses. A five-point Likert scale was used. Data were analyzed using Statistical Package for the Social Science (SPSS) v 20 software. Two hundreds and fourteen of the 236 questionnaires distributed were analyzed (response rate = 90.7 %). More than 51 % of the respondents reported that they couldn't identify the normal tissue counterpart of most practical pathology cases. Only 31.3 % thought their practical histology knowledge was beneficial for them in practical pathology. More than 87 % agreed or strongly agreed that pathology cases need to be copresented with normal tissue examples. A significant proportion of the respondents (60.7 %) were with merging histology and pathology in integrated courses. Pathology was of career choices for only 15.4 % of the participants. The curricular integration of histology and pathology in the first year needs to be tested, and much effort is needed to increase students' affinity for anatomic pathology.


Las percepciones y comentarios de los estudiantes tienen un impacto significativo en el progreso académico. El objetivo de este estudio fue determinar las percepciones de los estudiantes de medicina con respecto a los efectos acumulativos del curso de Histología general de primer año y del curso introductorio de Patología de segundo año, además de sus percepciones con respecto a la integración curricular de Histología y Patología. En este estudio transversal, se entregó un cuestionario a estudiantes de medicina de segundo y tercer año, a mediados del segundo semestre. Asimismo, el cuestionario comprendió varios aspectos referente a la actitud de los estudiantes hacia Patología Anatómica, sus comentarios sobre la Histología general en el primer año y los cursos de Patología de segundo año. Además se incorporaron las percepciones de los estudiantes con respecto a la integración de los cursos de Histología y Patología. Se utilizó una escala de Likert de cinco puntos. Los datos se analizaron utilizando el paquete Statistical Package for Social Science (SPSS) v 20. Se analizaron 214 de los 236 cuestionarios distribuidos (tasa de respuesta = 90,7 %). Más del 51 % de los encuestados indicaron estar de acuerdo o totalmente de acuerdo, en que no lograron identificar el tejido normal, en la mayoría de los casos de Patología práctica. Solo el 31,3 % observó que su conocimiento de Histología práctica era beneficioso para ellos durante la Patología práctica. Más del 87 % estuvo de acuerdo o muy de acuerdo en que los casos de Patología deben ser analizados con muestras de tejido normal. Un grupo importante de los encuestados (60,7 %) consideraba incorporar la Histología y la Patología en cursos integrados. Patología fue de elección en la carrera para el 15,4 % de los participantes. La integración curricular de Histología y Patología en el primer año, debe ser evaluada con el propósito de incrementar la afinidad de los estudiantes con la Patología Anatómica.


Subject(s)
Humans , Male , Female , Adult , Young Adult , Pathology/education , Students, Medical/psychology , Curriculum , Histology/education , Perception , Cross-Sectional Studies , Surveys and Questionnaires , Educational Measurement
12.
Int. j. morphol ; 38(1): 56-60, Feb. 2020. tab, graf
Article in Spanish | LILACS | ID: biblio-1056397

ABSTRACT

La lectura comprensiva de los términos médicos es relevante para un proceso de aprendizaje exitoso. Una de las estrategias para lograrlo es el conocimiento y aprendizaje de los orígenes latín y griego de las palabras, así el objetivo del presente trabajo fue investigar el significado y evolución del lexema griego plasma πλασµα y analizar la Terminologia Histologica en relación a un grupo de términos histológicos derivados de este lexema.


Comprehensive reading of medical terms is relevant to a successful learning process. One of the strategies to achieve this is the knowledge and learning of the Latin and Greek root of words. The aim of the present work was to investigate the meaning and evolution of the Greek lexeme plasma πλασµα, and to analyze the Terminologia Histologica in relation to a group of histological terms derived from this lexeme.


Subject(s)
Humans , Plasma , Histology , Terminology as Topic
13.
Neotrop. ichthyol ; 18(1): e190092, 2020. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1098404

ABSTRACT

Cardinal tetra Paracheirodon axelrodi and bloodfin tetra Aphyocharax anisitsi are two species of characids with high trade value as ornamental fish in South America. Although both species inhabit middle water layers, cardinal neon exhibits a tropical distribution and bloodfin tetra a subtropical one. Generally, these species are difficult to grow, so it becomes essential to know some key components of the neuroendocrine system to achieve their reproduction in captivity. Considering the importance of deepening the knowledge of the reproductive physiology through functional morphology, for the first time in this work we performed an anatomical, morphological and immunohistochemical analysis of the pituitary gland of these two species. In both species, a leptobasic type pituitary is found in the ventral zone of the hypothalamus and it is characterized by a neurohypophysis which has a well-developed pituitary stalk and a globular adenohypophysis. The pituitary components, characterized by histochemistry and immunohistochemistry, shows a distribution pattern of cells types similar to other teleost species, with only slight differences in the distribution of βFSH and βLH for P. axelrodi.(AU)


El cardenal tetra Paracheirodon axelrodi y el tetra Aphyocharax anisitsi son dos especies de carácidos con alto valor comercial como peces ornamentales en América del Sur. Aunque ambas especies habitan en las capas medias de agua, el neón cardenal exhibe una distribución tropical, mientras que el tetra cola roja una distribución subtropical. En general estas especies son difíciles de cultivar, por lo que es esencial conocer algunos componentes clave de los sistemas neuroendocrinos para lograr su reproducción en cautiverio. Considerando la importancia de profundizar en el conocimiento de la fisiología reproductiva a través de la morfología funcional, en este trabajo realizamos, por primera vez, un análisis anatómico, morfológico e inmunohistoquímico de la glándula pituitaria de estas dos especies. En ambas especies, la hipófisis, del tipo leptobásica, se encontró en la zona ventral del hipotálamo y se caracteriza por una neurohipófisis con un tallo hipofisario bien desarrollado y una adenohipófisis globular. Los componentes hipofisarios, caracterizados por la histoquímica y la inmunohistoquímica, mostraron un patrón de distribución de tipos de células similares a otras especies de teleósteos, con solo pequeñas diferencias en la distribución de βFSH y βLH para P. axelrodi.(AU)


Subject(s)
Animals , Pituitary Gland/enzymology , Immunohistochemistry/veterinary , Characiformes/anatomy & histology , Characiformes/immunology , Histology
14.
Rev. Méd. Paraná ; 78(2): 75-78, 2020.
Article in Portuguese | LILACS | ID: biblio-1222894

ABSTRACT

Justificativa: A Doença do Refluxo Gastroesofágico (DRGE) apresenta alta prevalência na população mundial. Uma de suas complicações, é o esôfago de Barrett (EB), uma alteração histológica pré-maligna do epitélio esofágico. O seu diagnóstico se da através do exame endoscópico e posterior confirmação histopatológica. Objetivo: Estimar a concordância diagnóstica, nos casos suspeitos de EB, entre o exame endoscópico e a análise histológica. Métodos: Foram analisados 151 pacientes, retrospectivamente, com suspeita diagnóstica de EB na endoscopia. Os dados foram obtidos a partir de prontuários eletrônicos, entre Julho de 2013 e Julho de 2014. Os laudos anatomopatológicos foram obtidos através de registros do laboratório Byori. Resultados: Entre os 151 pacientes submetidos a biópsias com suspeita endoscópica de EB, 47 (31,1%) obtiveram confirmação diagnóstica através do exame anatomopatológico. Conclusão: A endoscopia digestiva alta é um bom exame para detecção de metaplasia colunar, entretanto, nos casos de esôfago de Barrett, essa eficácia não se reproduziu.


Background: Gastroesophageal Reflux Disease (GERD) has a high prevalence in the world population. One of its complications is Barrett's esophagus (EB), a premalignant histological alteration of the esophageal epithelium. Its diagnosis is given through endoscopic examination and subsequent histopathological confirmation. Objective: Estimate at diagnostic agreement, we have suspense cases of EB, between endoscopic examination and histological analysis. Method: A total of 151 patients were retrospectively with suspected diagnosis of EB at endoscopy. Data were obtained from electronic medical records between July 2013 and July 2014. Anatomopathological reports were obtained from Byori laboratory records. Results: Among the 151 patients who underwent biopsy with endoscopic suspicion of EB, 47 (31.1%) obtained diagnostic confirmation through pathological examination. Conclusion: Upper digestive endoscopy is a good exam to detect columnar metaplasia, however, in Barrett's esophagus cases, this efficacy has not been reproduced.


Subject(s)
Humans , Barrett Esophagus , Duodenogastric Reflux , Endoscopy , Histology , Metaplasia
15.
Int. j. morphol ; 37(4): 1469-1474, Dec. 2019. tab, graf
Article in English | LILACS | ID: biblio-1040155

ABSTRACT

Histology belongs to the discipline of medical morphology. The knowledge is scattered and abstract in this discipline. It is difficult to the medical students beginner. Leading to poor effect on histology teaching. This study aimed to introduce medical students to the histology using barrier-based learning (BBL) method or traditional teaching method. We recruited 4 clinical medical classes, including two 5-years classes and two 7-years clinical medical classes, each of these classes randomly assigned to 1 of 2 groups. The control group received an introductory traditional teaching mode in histology. The experiment group received BBL method. Using final exam average scores, pass rate, excellent rates and phase tests to evaluate the teaching effect of these two teaching method. BBL teaching method is more effective than traditional teaching method, The application of BBL in histology is more easier to learning for the beginners of medical students.


La histología es una disciplina de la morfología médica. El conocimiento es disperso y abstracto en esta disciplina. Es una asignatura que resulta difícil para los estudiantes principiantes de medicina. Este estudio tuvo como objetivo presentar a los estudiantes de medicina la histología mediante el método de aprendizaje basado en barreras (BBL), comparándolo al método de enseñanza tradicional. Reclutamos estudiantes de 4 clases de medicina clínica, incluidas dos clases de quinto año y dos clases de medicina clínica de séptimo año, cada una de estas clases asignadas al azar a los grupos. El grupo de control recibió un método de enseñanza tradicional de introducción en histología. El grupo experimental recibió el método BBL. Usando los puntajes promedio del examen final, la tasa de aprobación, las tasas de excelencia y las pruebas de fase para evaluar el efecto de enseñanza de estos dos métodos de enseñanza, se determinó que el método de enseñanza de BBL es más efectivo que el método de enseñanza tradicional. La aplicación de BBL en histología permite un aprendizaje más sencillo para los estudiantes principiantes de medicina.


Subject(s)
Problem-Based Learning/methods , Education, Medical/methods , Histology/education , China
16.
Rev. bras. anal. clin ; 51(4): 286-289, 2019/12/30.
Article in Portuguese | LILACS | ID: biblio-1103942

ABSTRACT

Fungos são microrganismos que se desenvolvem em ambientes úmidos, produzindo, como metabolito secundário, micotoxinas, que contaminam alimentos e trazem danos à saúde. As micotoxinas são metabólicos produzidos por determinados gêneros de fungos filamentosos que acometem os produtos alimentícios e que, quando ingeridos, podem causar distúrbios ao organismo humano. Fungos se desenvolvem nos alimentos em qualquer fase do processo tendo condições favoráveis a eles, e uma vez que o alimento seja acometido pelo fungo as micotoxinas podem permanecer no alimento após a morte do fungo que as produz. Logo se faz pensar nos produtos ofertados. Este estudo constitui-se de uma revisão da literatura especializada, enfatizando os danos que os alimentos com micotoxinas podem causar ao organismo do ser humano. Para a coleta utilizaram-se o banco de dados Medline e os sites National Libray of Medicine (PubMed) e Scientific Eletronic Libray Online (SciELO), por meio das palavras-chave: fungos filamentosos; micotoxinas; produtos alimentícios. Sabe se que há um vasto número de micotoxinas, mas visando não só a perda econômica, mas também a saúde, pesquisas vêm se concentrando em algumas micotoxinas por apresentarem danos significativos já comprovados à saúde humana e animal, sem se descartar a possibilidade de outras apresentarem risco a saúde humana.


Fungi are microorganisms that grow in humid environments, producing, as a secondary metabolite, mycotoxins that contaminate food and bring harm to health. Metabolic mycotoxins are produced by certain genera of filamentous fungi that affect food products and which when ingested can cause disturbances to the human organism. Fungi develop in foods at any stage of the process having favorable conditions for them, and once the food is affected by the fungus the mycotoxins may remain in the food after the death of the fungus that produces them. One soon thinks about the products offered. This study is a review of the specialized literature, emphasizing the damage that foods with mycotoxins can cause to the human body. For collection it was used the Medline database and the National Libray of Medicine (Pubmed) and Scientific Electronic Libray Online (SciELO) websites, through the keywords: filamentous fungi; mycotoxins; food products. It is known that there is a large number of mycotoxins, but aiming not only economic loss, but also health, research has focused on some mycotoxins due to already proven significant damage to human and animal health, without ruling out the possibility of others presenting risk to human health.


Subject(s)
Pathology , Fungi , Mycotoxins , Histology
17.
Rev. bras. ortop ; 54(6): 692-696, Nov.-Dec. 2019. graf
Article in English | LILACS | ID: biblio-1057962

ABSTRACT

Abstract Objective The present work aimed to evaluate the systemic effect of H. speciosa latex on bone neoformation. Methods For this, the latex was collected and diluted to 3% and 50%. A total of 28 Wistar rats were submitted to surgery to create a 5 mm diameter defect in the parietal bone. This experiment was conducted in 2 different periods: 1 and 2. For each period, the rats were divided into 3 groups: Control Group, Latex3 Group, and Latex50 Group, which received, respectively, daily administrations of 0.5 mL of distilled water, latex to 3% and latex to 50% by gavage, orally. The rats of periods 1 and 2 were euthanized, respectively, 15 and 30 days after the surgery, and the calvaria was collected. The results were analyzed using the ANOVA and Tukey tests; the significance level was 0.05. Results We show that, in each analyzed period, the experimental groups had the same amount of newly formed bone in the calvaria defect. Conclusion We conclude that daily and oral administrations of H. speciosa latex to 3% and to 50% over a period of 15 and 30 days does not contribute to the increase of the area of the newly formed bone in the calvaria defect.


Resumo Objetivo Este trabalho objetivou avaliar o efeito sistêmico do látex de H. speciosas obre a neoformação óssea. Métodos Para isso, o látex foi coletado e diluído a 3% e a 50%. Um total de 28 ratos Wistar foi submetido a cirurgia para a criação de um defeito de 5 mm de diâmetro no osso parietal. Esse experimento foi conduzido em dois períodos distintos: 1 e 2. Para cada período, os ratos foram divididos em 3 grupos: Grupo Controle, Grupo Látex3 e Grupo Látex50 que receberam, respectivamente, administrações diárias de 0,5 mL de água destilada, látex a 3% e látex a 50% por gavagem, via oral. Os ratos dos períodos 1 e 2 foram eutanasiados, respectivamente, 15 e 30 dias após a cirurgia e a calvária foi coletada. Os resultados foram analisados utilizando os testes ANOVA e Tukey; o nível de significância estabelecido foi 0,05. Resultados Mostramos que, em cada período analisado, os grupos experimentais tiveram a mesma quantidade de osso neoformado no defeito da calvária. Conclusão Portanto, concluímos que administrações diárias e orais do látex de H. speciosa a 3% e a 50% durante um período de 15 e 30 dias não contribui para o aumento da área do osso neoformado no defeito da calvária.


Subject(s)
Animals , Rats , Bone and Bones , Complementary Therapies , Administration, Oral , Apocynaceae , Hematoxylin , Histology , Latex
18.
Rev. bras. ortop ; 54(5): 524-530, Sept.-Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1057938

ABSTRACT

Abstract Objective Lung cancer is the leading cause of death by cancer, and the bones are one of the most common sites of metastasis from this condition. This study aimed to evaluate the influence of lung carcinoma histology on the frequency of bone metastases. Methods This retrospective study evaluated the medical records of 407 patients diagnosed with lung cancer between 2003 and 2012. The prevalence of bone metastases and their association with histological subtypes were evaluated using chi-squared tests, odds ratios (ORs) and 95% confidence intervals (CIs). The overall survival was evaluated using the Kaplan-Meier method. Results The prevalence of bone metastases was 28.2% (n = 115), and the spine was the most frequently affected site (98 metastases; 32.1%). Adenocarcinoma was the most common histological subtype of lung carcinoma (46.7%), and it was significantly more frequent among patients with bone metastases (58.3% versus 42.1%; p = 0.003; OR = 1.92; 95% CI: 1.29-2.97). Squamous cell carcinoma was significantly less frequent among patients with bone metastases (13.0% versus 29.8%; p = 0.0004; OR = 0.35; 95% CI: 0.19-0.64). The median survival time after the first bone metastasis diagnosis was 4 months. Conclusion Adenocarcinoma was the most common histological subtype of lung carcinoma, and it was significantly associated with a higher risk of developing bone metastases.


Resumo Objetivo O câncer de pulmão é a principal causa de morte por neoplasia, e os ossos são os principais locais de metástases desse tipo de câncer. O objetivo deste estudo foi avaliar a influência do tipo histológico do carcinoma de pulmão na frequência das metástases ósseas. Métodos Foram avaliados retrospectivamente os registros médicos de 407 pacientes diagnosticados com câncer de pulmão entre 2003 e 2012. A prevalência de metástases ósseas e suas associações com os subtipos histológicos foram avaliadas com o teste qui-quadrado, razão de probabilidade (RP), e intervalos de confiança (IC) de 95%. A sobrevida global foi avaliada com o método de Kaplan-Meier. Resultados A prevalência das metástases ósseas foi de 28,2% (n = 115), e a coluna vertebral foi o local mais frequente (98 metástases: 32,1%). O adenocarcinoma foi o subtipo histológico mais comum de carcinoma pulmonar (46,7%) e foi significativamente mais frequente entre os pacientes com metástases ósseas (13,0% versus 29,8%; p = 0,0004; OR = 0,35; 95% IC: 0,19-0,64). O tempo médio de sobrevida após o diagnóstico da primeira metástase óssea foi de 4 meses. Conclusão O adenocarcinoma foi o subtipo histológico mais comum de carcinoma pulmonar e foi significativamente associado a um maior risco de desenvolvimento de metástases ósseas.


Subject(s)
Humans , Male , Female , Bone and Bones , Carcinoma, Squamous Cell , Adenocarcinoma , Retrospective Studies , Morbidity , Cause of Death , Histology , Lung Neoplasms , Neoplasm Metastasis
19.
Biosci. j. (Online) ; 35(2): 586-597, mar./apr. 2019. tab, graf, ilus
Article in English | LILACS | ID: biblio-1048612

ABSTRACT

Water salinity is among the most important factors influencing the distribution, abundance, growth, and survival of Crassostrea gasar, an important aquaculture resource grown in estuarine environments in diverse regions of the world. The goal of the present work was to evaluate the effects of different salinities on survival and the tissues ofC. gasar under laboratory conditions. Two experiments were performed using adult oysters from five marine farms located in the bay of Guaratuba, Brazil. In Experiment 1, the daily survival rates were evaluated after the oysters were submitted to gradual acclimatization at salinities ranging from 0 to 65 gL-1 and maintained in the laboratory without feeding for up to 365 days. In Experiment 2, the oysters were exposed to salinity from 0 to 50 gL-1 for up to 30 days without feeding and possible histological alterations caused by salinity were assessed. Three tolerance ranges of C. gasar to salinity were identified: "Optimal" (between 4 and 40 gL-1), "Tolerable" (between 2.1 and 3.9 and between 41 and 50 gL-1) and "Intolerable" (less than 2 and greater than 50 gL-1). No evidence of histological alterations was observed in oysters exposed to the different salinities.


A salinidade da água está entre os fatores de maior influência na distribuição, abundância, crescimento e sobrevivência de Crassostrea gasar, um importante recurso aquícola cultivado em ambientes estuarinos em diversas regiões do mundo. O objetivo desse trabalho foi avaliar os efeitos da salinidade sobre a sobrevivência e nos tecidos de C. gasar exposta a diferentes salinidades, em condições laboratoriais. Foram realizados dois experimentos com ostras adultas provenientes de cinco fazendas marinhas localizadas na baía de Guaratuba, Brasil. No experimento 1, que foi realizado com o propósito de avaliar as taxas diárias de sobrevivência, as ostras foram submetidas à aclimatação gradual a salinidades variando de 0 a 65 gL-1 e mantidas em laboratório, sem alimentação, por até 365 dias. No experimento 2, as ostras foram expostas a salinidades de 0 a 50 gL-1 por até 30 dias, sem alimentação, para avaliação de possíveis alterações histológicas provocadas pela salinidade. Foram identificadas três faixas de tolerância de C. gasar à salinidade: Ótima (entre 4 e 40 gL-1), Tolerável (entre 2,1 e 3,9 e entre 41 e 50 gL-1) e Intolerável (menor que 2 e maior que 50 gL-1). Não foram encontradas evidências de alterações histológicas em função da exposição das ostras às diferentes salinidades.


Subject(s)
Ostreidae , Estuaries , Crassostrea , Salinity , Histology
20.
Rev. colomb. gastroenterol ; 34(1): 31-37, ene.-mar. 2019. tab, graf
Article in Spanish | LILACS | ID: biblio-1003835

ABSTRACT

Resumen El cáncer colorrectal es una de las causas de mortalidad más importantes en los países occidentales. Desde cuando se estableció la progresión de adenoma a carcinoma, se ha considerado que los pólipos del colon son un factor de riesgo importante para desarrollar el cáncer colorrectal, por esta razón es importante el conocimiento, detección y resección, e investigación del tema. En Colombia no se han realizado estudios prospectivos que evalúen las características de los pólipos colorrectales, razón por la cual se considera de gran importancia la realización de este estudio con el objetivo de determinar las características endoscópicas e histopatológicas de los pólipos colónicos encontrados y resecados mediante colonoscopia. Se realizó un estudio observacional descriptivo, mediante el análisis de los pólipos resecados en pacientes del servicio de gastroenterología y endoscopia digestiva de la Clínica Universitaria Colombia. Se calculó un tamaño de muestra de forma probabilística (n = 306 pólipos resecados). En cuanto a la histología, y contrario a lo informado en la literatura, la mayoría de los pólipos detectados en nuestro estudio (170) fue de tipo adenomatoso (55,6 %). El mayor porcentaje de ellos (86 %) correspondió al tipo tubular, hallazgo acorde con lo mencionado en la literatura, la mayoría de ellos con displasia de bajo grado. Solo en 2 de nuestros pacientes se realizó el hallazgo de pólipos cuya histología diagnosticó la presencia de adenocarcinoma.


Abstract Colorectal cancer is one of the most important causes of death in Western countries. Since the progression from adenoma to carcinoma was established, it has been considered that colon polyps are an important risk factor for development of colorectal cancer, hence the importance of knowledge and research about them as well as their detection and resection. In our country there had been no prospective evaluations of the characteristics of colorectal polyps, so we considered this study to determine the endoscopic and histopathological characteristics of colonic polyps found and resected through colonoscopy to be of great importance. This descriptive and observational study includes analysis of polyps resected from patients inthe Gastroenterology and Digestive Endoscopy service of the Clínica Universitaria Colombia. Sample size was calculated probabilistically (n = 306 resected polyps). Contrary to reports in the literature, most of the polyps detected in our study (170) were adenomatous (55.6%). The highest percentage (86%) were tubular which is consistent with the literature. Most of them had low grade dysplasia. Only two of our patients had polyps found whose histology indicated adenocarcinoma.


Subject(s)
Humans , Colorectal Neoplasms , Colonic Polyps , Histology , Patients , Prospective Studies , Colonoscopy , Knowledge
SELECTION OF CITATIONS
SEARCH DETAIL