Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 2.312
Braz. dent. j ; 32(4): 96-105, July-Aug. 2021. tab
Article in English | LILACS, BBO | ID: biblio-1345515


Abstract This study evaluated the effect of post-cure heat treatment (PCHT) on the Knoop microhardness (KHN), degree of conversion (DC), color changes, and contrast ratio (CR) of four resin composites (RCs): Z100 (3M ESPE), Z350 XT (3M ESPE), Estelite Omega (Tokuyama) and Empress Direct (Ivoclar Vivadent). Specimens (12 × 1 mm) were prepared for each material (n = 10 / group). After curing, samples were subjected to PCHT for 10 min at 100°C or 170°C. Control group was maintained at room temperature (24°C) for the same time. The DC was analyzed by FT-NIR immediately and 24 h after the PCHT (n = 3 / group). KHN was analyzed 24 h after PCHT (n = 10 / group). According to CIEDE2000 (∆E00), color measurements were obtained immediately after curing, five minutes after PCHT, and after seven days of storage in water, coffee, and red wine. Data were analyzed by One and Two-Way ANOVA (p < 0.05). Z100, Z350, and Estelite Omega showed increases in KHN with increased temperature (p < 0.05). PCHT at 100°C and 170°C led to a higher DC of all RCs (p < 0.05). Initially, the PCHT lead to increased ∆E00 values (p < 0.05), which was decreased after immersion in coffee and wine (p < 0.05). Considering the effect of PCHT and staining solutions, lower color changes were observed in the thermally treated specimens (p < 0.05). Taken collectively, the results suggest the PCHT as an economical and practical alternative to enhance direct RC's properties in direct-indirect and indirect restorations.

Resumo Este estudo avaliou o efeito do tratamento térmico pós-cura (PCHT) na microdureza Knoop (KHN), grau de conversão (DC), mudanças de cor e razão de contraste (CR) de quatro compósitos resinosos (RCs): Z100 (3M ESPE ), Z350 XT (3M ESPE), Estelite Omega (Tokuyama) e Empress Direct (Ivoclar Vivadent). Corpos de prova (12 × 1 mm) foram preparadas para cada material (n = 10 / grupo). Após a cura, as amostras foram submetidas ao PCHT por 10 min a 100 ou 170° C. O grupo controle foi mantido à temperatura ambiente (24° C) pelo mesmo tempo. O DC foi analisada por FT-NIR imediatamente e 24 h após a PCHT (n = 3 / grupo). KHN foi analisado 24 h após PCHT (n = 10 / grupo). De acordo com o CIEDE2000 (∆E00), as medidas de cor foram obtidas imediatamente após a cura, cinco minutos após a PCHT e após sete dias de armazenamento em água, café e vinho tinto. Os dados foram analisados por ANOVA de um e dois fatores (P < 0,05). Z100, Z350 XT e Estelite Omega mostraram aumentos no KHN com o aumento da temperatura (P < 0,05). PCHT a 100 ° C e 170 ° C levou a uma maior DC de todos os RCs (P < 0,05). Inicialmente, o PCHT levou ao aumento dos valores de ∆E00 (P < 0,05), que diminuiu após a imersão em café e vinho (P < 0,05). Considerando o efeito de PCHT e soluções de coloração, menores mudanças de cor foram observadas nas amostras tratadas termicamente (P < 0,05). Os resultados sugerem o PCHT como uma alternativa econômica e prática para aumentar as propriedades diretas de compósitos resinosos em restaurações diretas-indiretas e indiretas.

Composite Resins , Hot Temperature , Surface Properties , Materials Testing , Coffee
Arch. med ; 21(1): 305-308, 2021/01/03.
Article in Spanish | LILACS | ID: biblio-1148465


Apreciado editor:La COVID-19, una pandemia sin precedentes causada por el coronavirus SARS-CoV2, ha afectado a millones de individuos desde su aparición en diciembre de 2019. El SARS-CoV2 puede transmitirse directa (tos, estornudo,aerosoles) o indirectamente (contacto con mucosas o superficies inanimadas) de individuo a individuo [1,2]..Au

Humans , Coronavirus Infections , Hot Temperature
Article in English | WPRIM | ID: wpr-878376


Climate change has been referred to as one of the greatest threats to human health, with reports citing likely increases in extreme meteorological events. In this study, we estimated the relationships between temperature and outpatients at a major hospital in Qingdao, China, during 2015-2017, and assessed the morbidity burden. The results showed that both low and high temperatures were associated with an increased risk of outpatient visits. High temperatures were responsible for more morbidity than low temperatures, with an attributed fraction (AF) of 16.86%. Most temperature-related burdens were attributed to moderate cold and hot temperatures, with AFs of 5.99% and 14.44%, respectively, with the young (0-17) and male showing greater susceptibility. The results suggest that governments should implement intervention measures to reduce the adverse effects of non-optimal temperatures on public health-especially in vulnerable groups.

Adolescent , Adult , Aged , Aged, 80 and over , Ambulatory Care/statistics & numerical data , Cardiovascular Diseases/therapy , Child , Child, Preschool , China/epidemiology , Cold Temperature/adverse effects , Cost of Illness , Digestive System Diseases/therapy , Facilities and Services Utilization/statistics & numerical data , Female , Hot Temperature/adverse effects , Humans , Infant , Infant, Newborn , Male , Middle Aged , Poisson Distribution , Respiratory Tract Diseases/therapy , Risk Factors , Young Adult
Article in Chinese | WPRIM | ID: wpr-877679


On the base of the principle of penetrating moxibustion and in combination with free adjustment devices such as movable U-shaped moxa stick holder and movable clamp, a new type of moxibustion box exerted on the head is designed, with precise positioning and sufficient heat intensity.

Hot Temperature , Moxibustion , Temperature , Workforce
Article in Chinese | WPRIM | ID: wpr-877598


OBJECTIVE@#To observe the clinical therapeutic effect of electroacupuncture (EA) combined with tamsulosin hydrochloride sustained release capsule on chronic prostatitis (CP) of damp and heat stasis.@*METHODS@#A total of 70 patients with CP of damp and heat stasis were randomized into an acupuncture plus medication group (35 cases, 4 cases dropped off) and a medication group (35 cases, 5 cases dropped off). In the medication group, tamsulosin hydrochloride sustained release capsule was given orally, 0.2 mg a time, once each night. On the basis of treatment in the medication group, EA was applied at Guanyuan (CV 4), Sanyinjiao (SP 6) and Yinglingquan (SP 9), with disperse-dense wave, 5 mA in intensity for 30 min. Treatment for 30 days was as one course, and totally 3 courses were required in both groups. Before treatment, 1, 2, 3 months into treatment and at the follow-up of 2 months after treatment, the TCM syndrome score and National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) score were observed, and the clinical efficacy was evaluated in both groups.@*RESULTS@#Compared before treatment, the TCM syndrome scores of 3 months into treatment and follow-up were decreased in the acupuncture plus medication group (@*CONCLUSION@#Acupuncture combined with medication can improve the clinical symptoms in patients with CP of damp and heat stasis, and its therapeutic effect is superior to simple western medication.

Acupuncture Points , Acupuncture Therapy , Chronic Disease , Hot Temperature , Humans , Male , Prostatitis/drug therapy , Treatment Outcome
Article in Chinese | WPRIM | ID: wpr-877562


OBJECTIVE@#To compare the clinical therapeutic effect between heat-sensitive moxibustion combined with western medication and simple western medication for low back pain of osteoporosis with kidney-@*METHODS@#A total of 60 patients with osteoporosis were randomized into an observation group (32 cases, 2 cases dropped off) and a control group (32 cases, 3 cases dropped off). In the control group, alendronate sodium tablet and calcium carbonate and vitamin D@*RESULTS@#The VAS scores, ODI scores and TCM clinical symptom scores after treatment were reduced in the two groups (@*CONCLUSION@#Heat-sensitive moxibustion combined with western medication could relieve low back pain, improve BMD in patients of osteoporosis with kidney-

Acupuncture Points , Hot Temperature , Humans , Kidney , Low Back Pain , Moxibustion , Osteoporosis/drug therapy , Yang Deficiency/drug therapy
Article in Chinese | WPRIM | ID: wpr-877552


According to the etiology, allergic diseases are related to wind and heat; according to the pathogenesis, most of allergic diseases are

Acupuncture Points , Acupuncture Therapy , Hot Temperature , Humans , Hypersensitivity/therapy , Meridians
Article in Chinese | WPRIM | ID: wpr-880436


Effects of heat treatment conditions (including temperature and time) on the shape memory recovery and corrosion resistance of NiTi self-expanding vascular stents were studied based on working mechanism and clinical use. The

Alloys , Corrosion , Hot Temperature , Materials Testing , Stents , Surface Properties , Temperature , Titanium
Article in English | WPRIM | ID: wpr-880371


BACKGROUND@#An acute upper respiratory tract infection (URI) is the most common disease worldwide, irrespective of age or sex. This study aimed to evaluate the short-term effect of diurnal temperature range (DTR) on emergency room (ER) visits for URI in Seoul, Korea, between 2009 and 2013.@*METHODS@#Daily ER visits for URI were selected from the National Emergency Department Information System, which is a nationwide daily reporting system for ER visits in Korea. URI cases were defined according to International Classification of Diseases, 10@*RESULTS@#There were 529,527 ER visits for URI during the study period, with a daily mean of 290 visits (range, 74-1942 visits). The mean daily DTR was 8.05 °C (range, 1.1-17.6 °C). The cumulative day (lag 02) effect of DTR above 6.57 °C per 1 °C increment was associated with a 1.42% (95% confidence interval [CI] 0.04-2.82) increase in total URI. Children (≤ 5 years of age) were affected by DTR above 6.57 °C per 1 °C, with 1.45% (95% CI 0.32-2.60) at lag 02, adults (19-64 years) with 2.77% (95% CI 0.39-5.20) at lag 07. When the DTR (lag02) was 6.57 °C to 11.03 °C, the relative risk was significant at 6.01% (95% CI 2.45-9.69) for every 1 °C increase in youth subjects aged for 6 to 18 years.@*CONCLUSIONS@#DTR was associated with a higher risk for ER visits for URI. In addition, the results suggested that the lag effects and relative risks of DTR on URI were quite different according to age.

Acute Disease/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Cold Temperature/adverse effects , Emergency Service, Hospital/statistics & numerical data , Female , Hot Temperature/adverse effects , Humans , Infant , Infant, Newborn , Male , Middle Aged , Republic of Korea/epidemiology , Respiratory Tract Infections/etiology , Young Adult
Braz. j. med. biol. res ; 54(5): e10717, 2021. tab, graf
Article in English | LILACS | ID: biblio-1180740


Scorpion venom is a Chinese medicine for epilepsy treatment, but the underlying mechanism is not clear. Scorpion venom heat-resistant peptide (SVHRP), a peptide isolated from the venom of Buthus martensii Karsch, has an anti-epileptic effect by reducing seizure behavior according to a modified Racine scale. The present study aimed to investigate the molecular mechanism of SVHRP on temporal lobe epilepsy. The hippocampus and hippocampal neurons from kainic acid-induced epileptic rats were treated with SVHRP at different doses and duration. Quantitative RT-PCR and immunoblotting were used to detect the expression level of brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), cAMP-response element binding protein (CREB), stromal interaction molecule (STIM), and calcium release-activated calcium channel protein 1 (ORAI1). In the hippocampal tissues and primary hippocampal neuron cultures, SVHRP treatment resulted in increased mRNA and protein levels of BDNF and NPY under the epileptic condition. The upregulation of BDNF and NPY expression was positively correlated with the dose level and treatment duration of SVHRP in hippocampal tissues from kainic acid-induced epileptic rats. On the other hand, no significant changes in the levels of CREB, STIM, or ORAI1 were observed. SVHRP may exhibit an anti-epileptic effect by upregulating the expression of BDNF and NPY in the epileptic hippocampus.

Animals , Rats , Scorpion Venoms/toxicity , Epilepsy/chemically induced , Epilepsy/drug therapy , Peptides , Brain-Derived Neurotrophic Factor/metabolism , Hot Temperature , Hippocampus/metabolism , Kainic Acid/toxicity , Neurons
Braz. arch. biol. technol ; 64: e21190020, 2021. tab, graf
Article in English | LILACS | ID: biblio-1153295


HIGHLIGHTS Screening extremophile Bacillus strains from various Hot Springs Characterization Of Bacillus Strains Producing Highly Thermostable Amylase Genetic identification of the best strains

Abstract Currently thermostable Amylase represents a broad biotechnological interest and desired by a various industries. In this study, forty-six bacterial strains belonging to the genus Bacillus were isolated from various hot springs in the North West of Algeria based on their ability to degrade starch and produce amylase in Starch Agar medium. The majority of isolates showed a positive amylolytic activity. In order to select the most thermostables amylase the effect of temperature on enzymes was estimated, therefore the study of amylase thermostability was culminated by the selection of Four Strains having an interesting optimum of activity and range of stability, reaching 75 °C for the strains HBH1-2, HBH1-3, HBH3-1and 85 °C for the strain HC-2, This indicates that the Enzyme produced by retained strains have optimum activity at high temperature. The identity of the selected strains was established on the basis of the morphological, biochemical characteristics and phylogenetic position as determined by 16S Ribosomal DNA gene sequencing. The whole strains belonged to the genus Bacillus and their phylogeny were also reported in this study.

Bacillus/isolation & purification , Bacillus/classification , Hot Springs/microbiology , Amylases , Phylogeny , Bacillus/genetics , RNA, Ribosomal, 16S , Algeria , Hot Temperature
Biosci. j. (Online) ; 36(4): 1422-1428, 01-06-2020. tab, graf
Article in English | LILACS | ID: biblio-1147311


During the application of phytosanitary products in coffee trees, workers may be exposed to temperatures that could compromise their health. Exposure to occupational heat can lead to progressive dehydration, cramps, exhaustion and the possibility of thermal shock. Thus, knowing the levels of occupational heat that workers are exposed becomes important. This study aimed to evaluate workers' occupational exposure to heat during the application of phytosanitary products with manual costal pump in the coffee crops. The case study was developed at the IFSULDEMINAS school farm - Campus Inconfidentes in the months of September and October 2017. The occupational heat in the coffee crop was evaluated using the WBGTAVERAGE method, using TGD 400 thermal stress meter. The WBGT values found were compared to the exposure limits of NR 15 for the purposes of insalubrity classification and with NHO 06 for acclimatized and non-acclimatized workers. The results showed that the WBGT found is below the tolerance limit of NR 15, for the month of September. In October, the tolerance limit was exceeded in the period from 11:00 a.m. to 2:59 p.m., considering a continuous heavy activity and rest in the workplace, and the activity considered unhealthy. Considering the criteria of the NHO 06 it was observed that the limits of occupational exposure were exceeded in the month of October, for acclimatized and non-acclimatized workers. In September the occupational exposure limit of NHO 06 was exceeded only for non-acclimated workers. Therefore, the workers should be submitted to acclimatization during the phytosanitary application activity in the month of October.

Durante a aplicação de produtos fitossanitários no cafeeiro os trabalhadores podem estar expostos a temperaturas capazes de comprometer sua saúde. Exposição ao calor ocupacional pode levar a desidratação progressiva, câimbras, exaustão e possibilidade de choque térmico. Desta forma, conhecer os níveis de calor ocupacional que os trabalhadores estão expostos torna-se importante. O presente estudo teve como objetivo avaliar a exposição ocupacional ao calor de trabalhadores durante a aplicação de produtos fitossanitários com bomba costal manual na cultura do cafeeiro. O estudo de caso foi desenvolvido na fazenda-escola do IFSULDEMINAS ­ Campus Inconfidentes nos meses de setembro e outubro de 2017. Avaliou-se o calor ocupacional em lavoura cafeeira através do método do IBUTGMÉDIO, utilizando medidor de estresse térmico TGD 400. Os valores do IBUTG encontrados foram comparados aos limites de exposição da NR 15 para fins de classificação de insalubridade e com a NHO 06 para trabalhadores aclimatizados e não aclimatizados. Os resultados demostraram que o IBUTG encontrado está abaixo do limite de tolerância da NR15, para o mês de setembro. No mês de outubro o limite de tolerância foi ultrapassado no período das 11:00 às 14:59h, considerando uma atividade pesada contínua e descanso no próprio local de trabalho, sendo a atividade considerada insalubre. Ao considerarmos os critérios da NHO 06 observou-se que os limites de exposição ocupacional foram ultrapassados no mês de outubro, para trabalhadores aclimatizados e não aclimatizados. Em setembro o limite de exposição ocupacional da NHO 06 foi superado somente para trabalhadores não aclimatizados. Portanto os trabalhadores devem ser submetidos à aclimatização durante a atividade de aplicação de fitossanitários no mês de outubro.

Occupational Health , Hot Temperature
Ortodoncia ; 84(167): 20-24, jun. 2020. ilus, tab
Article in Spanish | LILACS | ID: biblio-1147554


Objetivo: Evaluar el comportamiento de los alambres de aleación de níquel-titanio con y sin propiedades de transformación térmica en la relación carga/deflexión. Materiales y método: Para ello, 30 segmentos de alambres de níquel-titanio con calibre .014" y 30 mm de largo fueron cortados, conformando 10 segmentos de alambre Flexy NiTi de Orthometric®, 10 segmentos Flexy Copper NiTi termoactivado y 10 segmentos CuNiTi de OrmcoTM. Se usó una máquina universal de ensayos Instron® para analizar el comportamiento de carga y deflexión de los segmentos en una prueba de tres puntos, registrando las fuerzas alcanzadas en 0,5 mm: 1 mm, 2 mm y 4 mm de deflexión. Resultados: Hubo una diferencia estadísticamente significativa entre todos los alambres y entre todas las deflexiones, ya que el alambre Flexy Cooper NiTi presentó la menor carga entre todas las deflexiones analizadas. Conclusión: Se concluye que los alambres termoactivados alcanzan fuerzas más leves, lo que los hace más apropiados para alineaciones iniciales, las cuales requieren un mayor rango de deflexión(AU)

Orthodontic Wires , Titanium/analysis , Pliability , Hot Temperature , Malocclusion , Nickel/analysis , Materials Testing
Arq. bras. med. vet. zootec. (Online) ; 72(2): 505-516, Mar./Apr. 2020. tab
Article in Portuguese | ID: biblio-1128387


Objetivou-se avaliar os efeitos da manipulação da temperatura de incubação sobre a resposta imune de codornas desafiadas termicamente após eclosão. Para isso, foram utilizados 540 ovos, distribuídos em três incubadoras, com temperatura de 37,8°C e umidade de 60%. A partir do sexto dia de incubação até a eclosão, as temperaturas foram ajustadas em 37,8°C (padrão), 38,5°C (intermediária) e 39,5°C (alta). Após a eclosão as codornas foram pesadas e distribuídas, em delineamento inteiramente ao acaso, com três temperaturas de incubação (37,8, 38,5 e 39,5°C) e duas temperaturas de ambiente (estresse e termoneutro). Aos 10, 20, 30 e 40 dias, quatro codornas por tratamento foram eutanasiadas para coleta da bolsa cloacal, do fígado e do coração, para se determinar o peso absoluto (g), o peso relativo (%) e a área dos folículos bursais. Sangue foi coletado para realização do hemograma, do leucograma e da bioquímica sérica. Os dados foram analisados e as diferenças entre as médias foram determinadas pelo teste de Tukey a 5%. O estresse térmico por calor, a partir dos 20 dias, promove redução no peso absoluto do fígado, do coração, da bolsa cloacal e na área dos folículos bursais, além de heterofilia, linfopenia e aumento da relação heterófilo/linfócito. Em conclusão, o estresse térmico por calor após 10 dias de idade pode causar imunossupressão.(AU)

The objective of this study was to evaluate the effects of manipulation of the incubation temperature on the immune response of quails challenged thermally after hatching. For this, 540 eggs were distributed in three incubators, with temperature of 37.8°C and 60% humidity. From the 6th day of incubation to hatching the temperatures were adjusted to 37.8°C (standard), 38.5°C (intermediate) and 39.5°C (high). After hatching the quails were weighed and distributed in a completely randomized design with three incubation temperatures (37.8, 38.5 and 39.5°C) and two ambient temperatures (stress and thermoneutral). At 10, 20, 30 and 40 days four quail per treatment were euthanized to collect the cloacal burse, liver and heart to determine the absolute weight (g), relative weight (%) and area of the bursal follicles. Blood was sampled for determination of hemogram, leukogram and serum biochemistry. The data were analyzed and the differences between the means were determined by the Tukey test at 5%. Heat stress from 20 days onwards promotes a reduction in the absolute weight of the liver, heart, cloacal sac and in the area of the follicles. In addition, there was heterofilia, lymphopenia and increased heterophile/lymphocyte ratio. In conclusion, heat stress after 10 days of age can cause immunosuppression.(AU)

Animals , Cloaca/physiology , Heat Stress Disorders/veterinary , Coturnix/physiology , Hot Temperature , Immune Tolerance , Incubators , Leukocyte Count/veterinary
Arch. argent. pediatr ; 118(2): e183-e187, abr. 2020. ilus
Article in Spanish | LILACS, BINACIS | ID: biblio-1100433


La epilepsia refleja por agua caliente es un tipo de convulsión poco frecuente cuya fisiopatología se desconoce. Estas crisis reflejas suelen iniciarse pocos segundos tras el contacto con el agua y, comúnmente, a temperaturas de 37-48 ºC. Los automatismos y las crisis parciales complejas, con o sin generalización secundaria, son el modo de manifestación principal.La exploración neurológica y el electroencefalograma intercrítico no suelen presentar alteraciones, lo que puede condicionar un retraso en el diagnóstico, por lo que es fundamental la sospecha clínica.El tratamiento antiepiléptico se inicia cuando se asocia a otro tipo de epilepsia o cuando ciertas medidas sencillas, como el descenso de la temperatura del agua en el baño, no controlan las crisis. Es posible la desaparición espontánea. Cuando es necesaria la terapéutica farmacológica, existe, normalmente, buena respuesta.Se presenta el caso de un lactante con diagnóstico de epilepsia refleja por agua caliente.

Hot-water epilepsy is a rare type of seizure whose pathophysiology is unknown. These reflex seizures usually begin a few seconds after contact with water, commonly at temperatures between 37-48 ºC. Automations and complex partial crises, with or without secondary generalization, are the main manifestation mode of this type of reflex epilepsies.Neurological examination and intercritical electroencephalography are usually normal, which may condition a delay in diagnosis, and the clinical suspicion is fundamental.Antiepileptic treatment is initiated when associated with another type of epilepsy or when certain simple measures, such as lowering the water temperature in the bath, do not control crises. Spontaneous disappearance is possible; when pharmacological therapy is necessary, there is usually a good response.We present the case of an infant diagnosed with hot-water epilepsy.

Humans , Male , Infant , Epilepsy, Reflex/diagnosis , Seizures , Baths , Epilepsy, Reflex/drug therapy , Hot Temperature
Rev. bras. med. fam. comunidade ; 15(42): 1948-1948, 20200210. tab, ilus
Article in Portuguese | LILACS, ColecionaSUS | ID: biblio-1050316


Introdução: A exposição nociva ao calor ganha mais relevância com a progressão do aquecimento global antropogênico e a Atenção Primária à Saúde (APS) tem um papel crescente nesse cenário. No Brasil, as ondas de calor entre 2014 e 2015 duraram mais tempo que nos anos prévios, além disso, entre 2000-2015 a associação entre temperatura e hospitalizações variou de acordo com a duração da exposição ao calor. Nesse contexto, o objetivo desta revisão é realizar uma atualização sobre manejo clínico de patologias relacionadas ao calor na APS. Metodologia: Realizou-se a busca na base de dados ACCESSS, que utiliza a pirâmide 5.0 da assistência à saúde baseada em evidências. Foram identificados 103 sumários sintetizados para referência clínica com as palavras "Heat stress", "Heat Stroke", "Heat Wave" e "Heat Exhaustion", mas apenas três entravam no escopo deste estudo. Resultados e Discussão: O estresse pelo calor é uma condição comum, negligenciada e evitável que afeta diversos pacientes, iniciando-se com uma má adaptação ao calor que se não for corrigida pode gerar uma cascata de eventos inflamatórios. O estresse pelo calor é caracterizado por sintomas inespecíficos, como mal-estar, cefaleia e náusea. O tratamento envolve o resfriamento do paciente e monitoramento, garantindo hidratação adequada. A exaustão pelo calor, se não tratada, pode evoluir para insolação, uma doença grave que pode levar ao coma e morte, envolvendo disfunção do sistema nervoso central - necessitando de um tratamento mais agressivo além do resfriamento

Introduction: The nocive exposure to heat gets more attention with anthropogenic global warming, and Primary Health Care (PHC) has a growing role in this scenario. In Brazil heat waves between 2014 and 2015 lasted longer than in previous years. Further, in addition between 2000-2015 the association between temperature and hospitalizations varied according to the duration of heat exposure. Therefore, the aim of this review is to perform an update on clinical management of heat related pathologies in PHC. Methodology: The ACCESSS database was searched using the evidence-based health care pyramid 5.0, where we identified 103 synthesized summaries for clinical reference with words "Heat stress", "Heat Stroke", "Heat Wave" and "Heat Exhaustion", but only three fell within the scope of this study. Results and Discussion: Heat stress is a common, neglected and preventable condition that affects several patients, it starts with a poor adaptation to heat that if it is not adjusted it can generate a cascade of inflammatory events. Heat stress is characterized by nonspecific symptoms such as malaise, headache and nausea. The treatment involves patient monitoring and cooling, ensuring adequate hydration. Heat exhaustion, if untreated, can progress to heatstroke, a serious illness that can lead to coma and death, involving central nervous system dysfunction - requiring more aggressive treatment than cooling.

Introducción: La exposición nociva al calor gana más destaque con la progresión del calentamiento global antropogénico, y la Atención Primaria a la Salud tienen un papiel cresciente en este escenario. En Brasil las olas de calor entre 2014 y 2015 duraron más tiempo que en los años previos, además entre 2000-2015 la asociación entre temperatura y hospitalizaciones ha variado de acuerdo con la duración de la exposición al calor. En este contexto, el objetivo de esta revisión es realizar una actualización sobre manejo clínico de patologías relacionadas al calor en la APS. Metodología: Se realizó la búsqueda en la base de datos ACCESSS, que utiliza la pirámide 5.0 de la asistencia a la salud basada en evidencias. Se han identificado 103 sumarios sintetizados para referencia clínica con las palabras "Heat stress", "Heat Stroke", "Heat Wave" y "Heat Exhaustion", pero sólo tres son considerados en el ámbito de este estudio. Resultados y Discusión: El estrés por el calor es una condición común, descuidada y evitable que afecta a varios pacientes, iniciándose con una mala adaptación al calor que si no se corrige puede generar una cascada de eventos inflamatorios. El estrés por el calor se caracteriza por síntomas inespecíficos, como malestar, cefalea y náuseas. El tratamiento implica el enfriamiento del paciente y el monitoreo, garantizando la hidratación adecuada. El agotamiento por el calor, si no se trata, puede evolucionar hacia la insolación, una enfermedad grave que puede llevar al coma y a la muerte, involucrando disfunción del sistema nervioso central - necesitando un tratamiento más agresivo además del enfriamiento.

Heat Stress Disorders , Heat Wave (Meteorology) , Hot Temperature , Heat Exhaustion
Braz. j. biol ; 80(1): 30-38, Feb. 2020. graf
Article in English | LILACS | ID: biblio-1089276


Abstract Temperature is one of the main factors that influences cardiovascular functioning in ectotherms. Hence this study sought to investigate heart rate responses of a freshwater crab species, Poppiana dentata, to different temperature exposures since the species generally reside in habitats of fluctuating physicochemistry. Heart rates were non-invasively determined in juvenile crabs for three temperature regimes, each over an 8-day session; A: temperature exposures of 26 °C (2 days) to 30 °C (3 days) to 26 °C (3 days), B: 26 °C (2 days) to 32 °C (3 days) to 26 °C (3 days) and C: a control at constant 26 °C. Heart rate variations were significant among the regimes (P < 0.05), with the median heart rate being highest for regime B (74 beats per minute or bpm) during the temperature insult (32 °C), relative to regime A (70 bpm) and the control (64 bpm). Notably, a suppression and inversion of the diurnal cardiac patterns occurred for regimes' A and B crabs respectively, with rates from the highest temperature insult not shifting back to pre-insult levels during recovery (26 °C). It is plausible that P. dentata may have compensatory cardiovascular mechanisms that account for these differential heart rate responses, possibly conveying adaptive strategies in its dynamic habitat conditions.

Resumo A temperatura é um dos principais fatores que influenciam o funcionamento cardiovascular dos animais ectotérmicos. Sendo assim, este estudo buscou investigar as respostas de frequência cardíaca de uma espécie de caranguejo de água doce, o Poppiana dentata, após exposição a temperaturas diferentes, visto que esta espécie geralmente reside em habitats de composição físico-química variável. As frequências cardíacas foram determinadas de maneira não invasiva em caranguejos jovens submetidos a três regimes de temperatura, cada um ao longo de uma sessão de oito dias de duração; A: exposição a 26oC (dois dias) para 30 °C (três dias) para 26 °C (dois dias), B: 26 °C (dois dias) para 32 °C (três dias) para 26 °C (três dias) e C: um controle a temperatura constante de 26 °C. As variações de frequência cardíaca foram significativas entre os regimes (P < 0,05), sendo que a frequência cardíaca mediana foi mais alta para o regime B (74 batimentos por minuto ou bpm) durante o insulto térmico (32 °C), em relação ao regime A (70 bpm) e ao controle (64 bpm). Observou-se particularmente uma supressão e uma inversão dos padrões cardíacos diurnos nos caranguejos dos regimes A e B, respectivamente, sem que as frequências do insulto térmico mais alto voltassem aos níveis anteriores ao insulto térmico durante a recuperação (26 °C). É possível que o P. dentata possua mecanismos cardiovasculares compensatórios responsáveis por essas respostas de frequências cardíacas variadas, o que pode indicar estratégias de adaptação às suas condições de habitat dinâmicas.

Ecosystem , Hot Temperature , Temperature , Heart , Heart Rate
Article in Chinese | WPRIM | ID: wpr-828447


Lonicerae Japonicae Flos has a long history of heat-clearing and detoxifying effect. The description of its efficacy in Chinese Pharmacopoeia of past dynasties is relatively stable, and it is an excellent carrier for the study of efficacy markers. Guided by the theory of systematic traditional Chinese medicine, heat-clearing and detoxifying effect efficacy system of Lonicerae Japonicae Flos was taken as an example in this study to clarify the elements(active ingredients) of Lonicerae Japonicae Flos in heat-clearing and detoxifying efficacy system, determine the boundary(signal pathway), establish the structure(system dynamics model), identify the system functions corresponding to pharmacology, efficacy and effects(heat-clearing and detoxifying effect), and explore the application of system dynamics model in the discovery of efficacy markers of traditional Chinese medicine. In this paper, the dynamic models of interleukin 1(IL-1) and interleukin 6(IL-6) in vivo were established to predict the expression of related factors in IL-1 and IL-6 signaling pathways of different components and their combinations in Lonicerae Japonicae Flos by dynamic network, so as to find the effective markers of heat-clearing and detoxification of Lonicerae Japonicae Flos. The results showed that the lower the concentration of chlorogenic acid, the higher the inhibition rate of Jun N-terminal kinase(JNK) at downstream of IL-1 by the combination of chlorogenic acid and linalool; the higher the concentration of luteolin in IL-6 pathway, the higher the inhibition rate of C-reactive protein(CRP) at downstream of IL-6 by the combination of chlorogenic acid and luteolin. It revealed that the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-1 signaling pathway were chlorogenic acid and linalool, and the potential efficacy markers of Lonicerae Japonicae Flos in heat-clearing and detoxifying effect based on IL-6 signaling pathway were chlorogenic acid and luteolin. This study provided methodological guidance for the discovery of efficacy markers of traditional Chinese medicine.

Chromatography, High Pressure Liquid , Drugs, Chinese Herbal , Hot Temperature , Lonicera , Medicine, Chinese Traditional , Quality Control
Article in Chinese | WPRIM | ID: wpr-828381


The current study was conducted to explore the effects of light intensity in cultivating environment on the cleaning away heat property of Viola yedoensis. In the present study, we established the acute inflammation model of ICR mice by injecting carrageenan. We compared the effects of V. yedoensis grown under different light intensities(100%, 80%, 50%, 35% and 5% of full sunlight) on mice body temperature, thermal radiation and the swelling degree of foot tissue before and after modeling observing by thermal infrared imaging technique and weighing method. The changes of energy metabolism related enzymes in liver were detected by enzyme-linked immunosorbent assay(ELISA). In addition, the effects of V. yedoensis grown under different light intensities on human lung cancer cell A549 proliferation were explored with MTT method. The results showed that the body temperature of all groups of mice in V. yedoensis group were significantly lower than that of the blank group, except 5% full sunlight group, and the body temperature declined in positive proportion to light intensity. V. yedoensis group could alleviate foot swelling, reduce SDH activity in liver tissue(especially 100% full sunlight group and 80% full sunlight group were significantly lower than model group), and the degree of alleviating and reducing was positively correlated with light intensity. There was no significant difference in the activity of Na~+-K~+-ATPase and Ca~(2+)-Mg~(2+)-ATPase in liver tissue among treatments. The contents of IL-1β, IL-6, TNF-α, PGE_2 in foot tissue of mice in V. yedoensis groups were significantly lower than those in model group. Among them, the lowest levels of IL-1β, IL-6, TNF-α, PGE_2 were found in 80% full sunlight group, and there was no significant difference in TNF-α among different groups. The effects of V. yedoensis aqueous extract on A549 cell line proliferation inhibition rate increased with the light intensities of V. yedoensis cultivating environment. And the effects of V. yedoensis grown under 100% of full sunlight showed significantly higher A549 cell line proliferation inhibition rate compared with other groups(P<0.05). In summary, the light intensity of V. yedoensis cultivating environment is positively correlated with the cleaning away heat property of V. yedoensis, which conforms to the "light-cold and heat property" hypothesis,The V. yedoensis should be planted under full light according.

Animals , Hot Temperature , Inflammation , Mice , Mice, Inbred ICR , Tumor Necrosis Factor-alpha , Viola